Page last updated: 2024-08-23

paroxetine and valproic acid

paroxetine has been researched along with valproic acid in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.23)18.2507
2000's14 (45.16)29.6817
2010's15 (48.39)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Dansette, PM; Fontana, E; Poli, SM1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Deltito, JA1
Joffe, RT; MacQueen, GM; Marriott, M; Patelis-Siotis, I; Robb, JC; Young, LT1
Bowden, CL; Evans, DL; Gergel, IP; Gyulai, L; Nemeroff, CB; Oakes, R; Pitts, CD; Sachs, GS1
Koyama, T; Suzuki, K1
Salerian, AJ1
Bertschy, G; Bondolfi, G; Golaz, J; Rachid, F1
Bajbouj, M; Danker-Hopfe, H; Gallinat, J; Hellen, F; Lang, UE; Lisanby, SH; Neu, P; Vesper, J1
Alexander, T; Ances, BM; Ellis, RJ; Letendre, SL1
Calabrese, JR; Findling, RL; Lingler, J; McNamara, NK; Rowles, BM1
Howland, RH1
Calabrese, JR; Cao, L; Chen, J; Cui, X; Fang, Y; Gao, K; Hong, W; Jiang, K; Wang, Y; Wu, Z; Xu, Y; Yi, Z; Yuan, C1
Bhattacharya, A; Katshu, MZ; Nizamie, SH1
Kamal, SM1
Aragão, I; Cardoso, T; Guedes, F; Maia, JM1
Asz-Sigall, D; Guzmán-Sánchez, D1
Bianchi, L; Del Duca, E; Esposito, M; Fargnoli, MC; Giunta, A; Manfreda, V; Troisi, A1

Reviews

6 review(s) available for paroxetine and valproic acid

ArticleYear
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
    Current drug metabolism, 2005, Volume: 6, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Pharmacokinetics and drug interaction of antidepressants and anti-manic drugs].
    Ryoikibetsu shokogun shirizu, 2003, Issue:38

    Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Antimanic Agents; Carbamazepine; Cyclopropanes; Cytochrome P-450 Enzyme System; Drug Interactions; Fluvoxamine; Humans; Isoenzymes; Lithium; Milnacipran; Paroxetine; Selective Serotonin Reuptake Inhibitors; Valproic Acid

2003
Role of psychiatric medications as adjunct therapy in the treatment of HIV associated neurocognitive disorders.
    International review of psychiatry (Abingdon, England), 2008, Volume: 20, Issue:1

    Topics: Antiretroviral Therapy, Highly Active; Brain; Citalopram; Cognition Disorders; HIV Infections; Humans; Lithium Carbonate; Mental Disorders; Paroxetine; Psychotropic Drugs; Selective Serotonin Reuptake Inhibitors; Valproic Acid

2008
Efficacy of paroxetine in primary palmoplantar hyperhidrosis occurring with juvenile myoclonic epilepsy.
    Dermatology (Basel, Switzerland), 2011, Volume: 223, Issue:3

    Topics: Adolescent; Anticonvulsants; Drug Therapy, Combination; Female; Hand; Humans; Hyperhidrosis; Myoclonic Epilepsy, Juvenile; Paroxetine; Quality of Life; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Valproic Acid

2011
Alopecias due to drugs and other skin and systemic disorders.
    Current problems in dermatology, 2015, Volume: 47

    Topics: Alopecia; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Dermatologic Agents; Dermatomycoses; Diet; Folliculitis; Herpes Zoster; HIV Infections; Humans; Isotretinoin; Lamotrigine; Lithium Compounds; Lupus Erythematosus, Systemic; Malnutrition; Mycosis Fungoides; Paroxetine; Sarcoidosis; Seasons; Skin Neoplasms; Starvation; Stress, Psychological; Syphilis; Triazines; Valproic Acid

2015

Trials

5 trial(s) available for paroxetine and valproic acid

ArticleYear
Double-blind comparison of addition of a second mood stabilizer versus an antidepressant to an initial mood stabilizer for treatment of patients with bipolar depression.
    The American journal of psychiatry, 2000, Volume: 157, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Antimanic Agents; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Hospitalization; Humans; Lithium Chloride; Male; Paroxetine; Patient Dropouts; Psychiatric Status Rating Scales; Treatment Outcome; Valproic Acid

2000
Double-blind, placebo-controlled comparison of imipramine and paroxetine in the treatment of bipolar depression.
    The American journal of psychiatry, 2001, Volume: 158, Issue:6

    Topics: Adult; Aged; Ambulatory Care; Anticonvulsants; Antidepressive Agents, Tricyclic; Bipolar Disorder; Carbamazepine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Imipramine; Lithium; Male; Middle Aged; Paroxetine; Placebos; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Valproic Acid

2001
Motor cortex excitability after vagus nerve stimulation in major depression.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:2

    Topics: Adult; Benzodiazepines; Citalopram; Clomipramine; Clozapine; Depressive Disorder; Doxepin; Drug Therapy, Combination; Electric Stimulation; Female; Humans; Lamotrigine; Lithium Carbonate; Male; Mianserin; Middle Aged; Mirtazapine; Morpholines; Motor Cortex; Neural Conduction; Neural Inhibition; Olanzapine; Paroxetine; Psychiatric Status Rating Scales; Reboxetine; Tranylcypromine; Triazines; Vagus Nerve; Valproic Acid

2007
A pilot pharmacotherapy trial for depressed youths at high genetic risk for bipolarity.
    Journal of child and adolescent psychopharmacology, 2008, Volume: 18, Issue:6

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Antimanic Agents; Bipolar Disorder; Child; Child of Impaired Parents; Depressive Disorder, Major; Drug Therapy, Combination; Female; Humans; Male; Paroxetine; Pilot Projects; Risk Factors; Valproic Acid

2008
A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone, trazodone, or thyroid hormone in adult Chinese patients with treatment-resistant major depression.
    Journal of clinical psychopharmacology, 2011, Volume: 31, Issue:5

    Topics: Buspirone; China; Depressive Disorder, Major; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Paroxetine; Pilot Projects; Psychiatric Status Rating Scales; Remission Induction; Risperidone; Selective Serotonin Reuptake Inhibitors; Thyroid Hormones; Trazodone; Valproic Acid

2011

Other Studies

20 other study(ies) available for paroxetine and valproic acid

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Valproate pretreatment for the difficult-to-treat patient with OCD.
    The Journal of clinical psychiatry, 1994, Volume: 55, Issue:11

    Topics: 1-Naphthylamine; Antidepressive Agents; Clomipramine; Drug Therapy, Combination; Fluoxetine; Humans; Obsessive-Compulsive Disorder; Paroxetine; Sertraline; Treatment Outcome; Valproic Acid

1994
Pharmaceutical drug overdose case reports. From the World Literature.
    Toxicological reviews, 2003, Volume: 22, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Aged; Amlodipine; Child, Preschool; Diphenhydramine; Dizocilpine Maleate; Drug Overdose; Female; Humans; International Normalized Ratio; Lithium; Male; Middle Aged; Paroxetine; Salicylates; Valproic Acid; Warfarin

2003
Successful treatment of sexual dysfunction with dronabinol: a case report.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:8

    Topics: Adult; Benzodiazepines; Bipolar Disorder; Dronabinol; Female; Humans; Libido; Olanzapine; Paroxetine; Psychotropic Drugs; Sexual Behavior; Sexual Dysfunctions, Psychological; Treatment Outcome; Valproic Acid

2004
Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2006, Volume: 7, Issue:4

    Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antimanic Agents; Depressive Disorder, Major; Female; Humans; Methadone; Mood Disorders; Narcotics; Opipramol; Paroxetine; Prazepam; Psychiatric Status Rating Scales; Serotonin Syndrome; Severity of Illness Index; Substance-Related Disorders; Transcranial Magnetic Stimulation; Trazodone; Valproic Acid

2006
When is a "generic" medication not really a generic?
    Journal of psychosocial nursing and mental health services, 2010, Volume: 48, Issue:2

    Topics: Bupropion; Cyclohexanols; Drug Costs; Drug Labeling; Drug Prescriptions; Drugs, Generic; Humans; Marketing of Health Services; Paroxetine; Patient Selection; Psychiatric Nursing; Psychotropic Drugs; Therapeutic Equivalency; United States; United States Food and Drug Administration; Valproic Acid; Venlafaxine Hydrochloride

2010
Combination of valproate and paroxetine in mice exposed to picrotoxin.
    International journal of nanomedicine, 2012, Volume: 7

    Topics: Animals; Anticonvulsants; Brain Chemistry; Drug Combinations; gamma-Aminobutyric Acid; Mice; Nucleus Accumbens; Paroxetine; Picrotoxin; Seizures; Selective Serotonin Reuptake Inhibitors; Thiobarbituric Acid Reactive Substances; Valproic Acid

2012
Eosinophilic pneumonia presenting as life-threatening ARDS.
    BMJ case reports, 2015, Jul-06, Volume: 2015

    Topics: Adult; Alprazolam; Antidepressive Agents, Second-Generation; Caustics; Cough; Drug Therapy, Combination; Eosinophilia; Eosinophils; Female; Glucocorticoids; Humans; Lye; Paroxetine; Prednisone; Pulmonary Eosinophilia; Radiography, Thoracic; Respiratory Distress Syndrome; Suicide, Attempted; Treatment Outcome; Valproic Acid

2015
Long-term safety and efficacy of secukinumab in patients with psoriasis and major psychiatric disorders: a case series.
    Postgraduate medicine, 2020, Volume: 132, Issue:2

    Topics: Adult; Agoraphobia; Antibodies, Monoclonal, Humanized; Antidepressive Agents; Antimanic Agents; Benzodiazepines; Bipolar Disorder; Depressive Disorder; Depressive Disorder, Major; Female; Humans; Lithium Carbonate; Male; Mental Disorders; Middle Aged; Nordazepam; Panic Disorder; Paroxetine; Psoriasis; Quetiapine Fumarate; Severity of Illness Index; Treatment Outcome; Valproic Acid

2020