Page last updated: 2024-08-23

paroxetine and trazodone

paroxetine has been researched along with trazodone in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.94)18.7374
1990's3 (8.82)18.2507
2000's18 (52.94)29.6817
2010's12 (35.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Asberg, M; Eriksson, B; Mårtensson, B; Träskman-Bendz, L; Wägner, A1
Young, C1
Preskorn, SH; Shad, MU1
Ellison, Z; Evans, CL; Fombonne, E; Ha, Y; Saisch, S1
Lebert, F1
Bateman, DN; Chick, J; Good, AM; Kelly, CA; Masterton, G1
Almarza, E; Martínez, MA; Sánchez de la Torre, C1
Fujimura, Y; Suhara, T1
Di Loreto, G; Dionisio, P; Kasper, S; Olivieri, L1
Albertazzi, P1
Bertschy, G; Bondolfi, G; Golaz, J; Rachid, F1
Ikeda, K; Kobayashi, T; Washiyama, K1
Ikenouchi-Sugita, A; Nakamura, J; Yoshimura, R1
Preskorn, SH1
Adachi, N; Ameno, K; Hishida, S; Kasuda, S; Kinoshita, H; Matsui, K; Minami, T; Nishiguchi, M; Ohtsu, N; Ouchi, H; Takahashi, M; Yoshida, S1
Auerbach, S; Brass, SD1
Calabrese, JR; Cao, L; Chen, J; Cui, X; Fang, Y; Gao, K; Hong, W; Jiang, K; Wang, Y; Wu, Z; Xu, Y; Yi, Z; Yuan, C1
Asarnow, JR; Birmaher, B; Brent, DA; Clarke, G; Emslie, GJ; Keller, MB; Porta, G; Ryan, N; Shamseddeen, W; Wagner, KD1
Baldo, P; Cecco, S; Doree, C; McFerran, D; Molin, P1
Baroni, M; Boccardi, V; Ercolani, S; Giordano, M; Longo, A; Mecocci, P; Paolacci, L; Ruggiero, C1
Baldwin, DS; Everitt, H; Lipinska, G; Malizia, AL; Manson, CC; Mayers, A; Stuart, B; Wilson, S1

Reviews

8 review(s) available for paroxetine and trazodone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Therapeutic effects of serotonin uptake inhibitors in depression.
    The Journal of clinical psychiatry, 1986, Volume: 47 Suppl

    Topics: 5-Hydroxytryptophan; Alanine; Citalopram; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Propylamines; Serotonin; Serotonin Antagonists; Trazodone; Zimeldine

1986
[Serotonin reuptake inhibitors in depression of Alzheimer's disease and other dementias].
    Presse medicale (Paris, France : 1983), 2003, Jul-26, Volume: 32, Issue:25

    Topics: Aged; Alzheimer Disease; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Clinical Trials as Topic; Dementia; Depression; Fluoxetine; Humans; Neuropsychological Tests; Paroxetine; Placebos; Selective Serotonin Reuptake Inhibitors; Time Factors; Trazodone

2003
[Biological pathophysiology of mood disorders special reference to the neurotransmitter receptors].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2004, Volume: 106, Issue:8

    Topics: Amoxapine; Animals; Antidepressive Agents, Second-Generation; Brain; Humans; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Mood Disorders; Nerve Tissue Proteins; Paroxetine; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D1; Receptors, Serotonin, 5-HT2; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Trazodone

2004
Noradrenergic and serotonergic modulation to treat vasomotor symptoms.
    The journal of the British Menopause Society, 2006, Volume: 12, Issue:1

    Topics: Citalopram; Cyclohexanols; Female; Fluoxetine; Hot Flashes; Humans; Menopause; Mianserin; Mirtazapine; Paroxetine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Trazodone; Venlafaxine Hydrochloride

2006
[Review of pharmacological efficacies and side effects of antidepressants].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Volume: 65, Issue:9

    Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Fluvoxamine; Humans; Imipramine; Maprotiline; Paroxetine; Sulpiride; Trazodone

2007
Antidepressants for patients with tinnitus.
    The Cochrane database of systematic reviews, 2012, Sep-12, Issue:9

    Topics: Amitriptyline; Antidepressive Agents; Depression; Humans; Nortriptyline; Paroxetine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Tinnitus; Trazodone; Trimipramine

2012
Antidepressants for insomnia in adults.
    The Cochrane database of systematic reviews, 2018, May-14, Volume: 5

    Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Fluoxetine; Humans; Mianserin; Paroxetine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Sleep Initiation and Maintenance Disorders; Trazodone

2018

Trials

3 trial(s) available for paroxetine and trazodone

ArticleYear
A comparative, randomised, double-blind study of trazodone prolonged-release and paroxetine in the treatment of patients with major depressive disorder.
    Current medical research and opinion, 2005, Volume: 21, Issue:8

    Topics: Adult; Aged; Delayed-Action Preparations; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors; Trazodone; Treatment Outcome; White People

2005
A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone, trazodone, or thyroid hormone in adult Chinese patients with treatment-resistant major depression.
    Journal of clinical psychopharmacology, 2011, Volume: 31, Issue:5

    Topics: Buspirone; China; Depressive Disorder, Major; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Paroxetine; Pilot Projects; Psychiatric Status Rating Scales; Remission Induction; Risperidone; Selective Serotonin Reuptake Inhibitors; Thyroid Hormones; Trazodone; Valproic Acid

2011
Adjunctive sleep medications and depression outcome in the treatment of serotonin-selective reuptake inhibitor resistant depression in adolescents study.
    Journal of child and adolescent psychopharmacology, 2012, Volume: 22, Issue:1

    Topics: Adolescent; Cognitive Behavioral Therapy; Combined Modality Therapy; Cyclohexanols; Cytochrome P-450 CYP2D6 Inhibitors; Depressive Disorder, Major; Drug Interactions; Drug Resistance; Female; Fluoxetine; Humans; Male; Paroxetine; Selective Serotonin Reuptake Inhibitors; Self-Injurious Behavior; Sleep Wake Disorders; Trazodone; Treatment Outcome; Venlafaxine Hydrochloride

2012

Other Studies

23 other study(ies) available for paroxetine and trazodone

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
    Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19

    Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution

2011
Species independence in brain tissue binding using brain homogenates.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
A case of neuroleptic malignant syndrome and serotonin disturbance.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:1

    Topics: Akathisia, Drug-Induced; Benztropine; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Lithium Carbonate; Middle Aged; Neuroleptic Malignant Syndrome; Neurologic Examination; Paroxetine; Perphenazine; Receptors, Serotonin; Trazodone

1997
Pharmacodynamic and pharmacokinetic factors in a case of neuroleptic malignant syndrome.
    Journal of clinical psychopharmacology, 1998, Volume: 18, Issue:4

    Topics: Antipsychotic Agents; Brain; Drug Interactions; Drug Therapy, Combination; Humans; Lithium Carbonate; Neuroleptic Malignant Syndrome; Paroxetine; Perphenazine; Selective Serotonin Reuptake Inhibitors; Trazodone

1998
Tricyclic antidepressants in adolescent depression. A case report.
    European child & adolescent psychiatry, 1998, Volume: 7, Issue:3

    Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Child; Depressive Disorder; Dothiepin; Drug Monitoring; Drug Therapy, Combination; Electrocardiography; Humans; Lithium Carbonate; Lofepramine; Male; Paroxetine; Trazodone

1998
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
    European journal of clinical pharmacology, 2004, Volume: 60, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Overdose; Drug Prescriptions; Emergency Service, Hospital; Female; Fluoxetine; Humans; Imipramine; Information Services; Male; Mianserin; Mirtazapine; Paroxetine; Patient Admission; Patient Readmission; Poison Control Centers; Retrospective Studies; Risk Assessment; Scotland; Selective Serotonin Reuptake Inhibitors; Self-Injurious Behavior; Sertraline; Trazodone; Venlafaxine Hydrochloride

2004
A comparative solid-phase extraction study for the simultaneous determination of fluvoxamine, mianserin, doxepin, citalopram, paroxetine, and etoperidone in whole blood by capillary gas-liquid chromatography with nitrogen-phosphorus detection.
    Journal of analytical toxicology, 2004, Volume: 28, Issue:3

    Topics: Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Chromatography, Gas; Chromatography, Liquid; Citalopram; Doxepin; Female; Fluvoxamine; Humans; Mianserin; Nitrogen; Paroxetine; Phosphorus; Reproducibility of Results; Trazodone

2004
Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2006, Volume: 7, Issue:4

    Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antimanic Agents; Depressive Disorder, Major; Female; Humans; Methadone; Mood Disorders; Narcotics; Opipramol; Paroxetine; Prazepam; Psychiatric Status Rating Scales; Serotonin Syndrome; Severity of Illness Index; Substance-Related Disorders; Transcranial Magnetic Stimulation; Trazodone; Valproic Acid

2006
Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine.
    Journal of pharmacological sciences, 2006, Volume: 102, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Generation; Barium; Cyclopropanes; Electrophysiology; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Hydrogen-Ion Concentration; Milnacipran; Oocytes; Paroxetine; Plasmids; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Receptor, Adenosine A1; Reverse Transcriptase Polymerase Chain Reaction; Selective Serotonin Reuptake Inhibitors; Trazodone; Xenopus laevis

2006
Neuroleptic malignant syndrome resulting from a complex drug-drug interaction: "I don't see 'em!".
    Journal of psychiatric practice, 2007, Volume: 13, Issue:5

    Topics: Benztropine; Bipolar Disorder; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Drug Therapy, Combination; Female; Humans; Lithium Compounds; Middle Aged; Neuroleptic Malignant Syndrome; Paroxetine; Perphenazine; Psychotropic Drugs; Trazodone

2007
A fatal case due to combined toxicity of psychotropic drugs.
    Forensic science international, 2008, Oct-25, Volume: 181, Issue:1-3

    Topics: Adult; Anti-Anxiety Agents; Brain Edema; Female; Flunitrazepam; Forensic Toxicology; Gastrointestinal Contents; Heart Arrest; Humans; Paroxetine; Pulmonary Edema; Selective Serotonin Reuptake Inhibitors; Trazodone

2008
A sleepy patient with REM rebound.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2009, Aug-15, Volume: 5, Issue:4

    Topics: Adult; Antidepressive Agents; Depressive Disorder; Diagnosis, Differential; Humans; Male; Narcolepsy; Paroxetine; Polysomnography; Sleep Wake Disorders; Trazodone

2009
Anticholinergic Burden and Functional Status in Older People with Cognitive Impairment: Results from the Regal Project.
    The journal of nutrition, health & aging, 2017, Volume: 21, Issue:4

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinergic Antagonists; Cognitive Dysfunction; Cross-Sectional Studies; Female; Hospitalization; Humans; Italy; Longitudinal Studies; Male; Memory; Outpatients; Paroxetine; Risperidone; Trazodone

2017