Page last updated: 2024-08-23

paroxetine and tramadol

paroxetine has been researched along with tramadol in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (18.75)18.2507
2000's4 (25.00)29.6817
2010's6 (37.50)24.3611
2020's3 (18.75)2.80

Authors

AuthorsStudies
De Laat, M; Devulder, J; Dumoulin, K; Renson, A; Rolly, G1
Brodie-Meijer, CC; Egberts, AC; ter Borgh, J1
Buchalter, EN; Giambanco, V; Lantz, MS1
Brøsen, K; Enggaard, TP; Laugesen, S; Pedersen, RS; Sindrup, SH1
Escrivá-Moscardó, S; Llinares-Tello, F; Martínez-Mascaraque, P; Martínez-Pastor, F1
John, AP; Koloth, R1
Olivier, B; Schweitzer, DH; Waldinger, MD; Zwinderman, AH1
Drummer, OH; Gerostamoulos, D; Pilgrim, JL1
Brosen, K; Damkier, P; Nielsen, AG; Noehr-Jensen, L; Pedersen, RS1
Alghobary, M; Amr, M; El-Bayoumy, Y; Mahmoud, el-HM; Mostafa, Y1
Dimpfel, W1
Esquivel Franco, DC; Olivier, B; Olivier, JD; Oosting, R; Sarnyai, Z; Waldinger, M1
Daali, Y; Desmeules, J; Lenglet, S; Matthey, A; Storelli, F; Thomas, A1
Cui, Y; Feng, F; Tan, H; Zhang, Y; Zhou, Z1
Cui, Y; Wang, Y; Yang, Z; Zhang, X; Zhang, Y; Zhou, Z1
Doss C, GP; Kumar S, U; Tayubi, IA1

Reviews

2 review(s) available for paroxetine and tramadol

ArticleYear
A systematic review and meta-analysis of randomized controlled trials of "on-demand" use of tramadol vs "on-demand" use of paroxetine in the management of patients with premature ejaculation.
    International journal of clinical practice, 2021, Volume: 75, Issue:11

    Topics: Ejaculation; Humans; Male; Paroxetine; Premature Ejaculation; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Tramadol; Treatment Outcome

2021
The network meta-analysis of "on-demand" and "daily" use of paroxetine in treating men with premature ejaculation from randomized controlled trials.
    Andrologia, 2022, Volume: 54, Issue:5

    Topics: Ejaculation; Humans; Male; Network Meta-Analysis; Paroxetine; Phosphodiesterase 5 Inhibitors; Premature Ejaculation; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Tramadol; Treatment Outcome

2022

Trials

3 trial(s) available for paroxetine and tramadol

ArticleYear
Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol.
    Clinical pharmacology and therapeutics, 2005, Volume: 77, Issue:4

    Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Second-Generation; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP2D6; Double-Blind Method; Drug Interactions; Female; Humans; Male; Molecular Conformation; Pain Threshold; Paroxetine; Tramadol; Treatment Outcome

2005
Two separate dose-dependent effects of paroxetine: mydriasis and inhibition of tramadol's O-demethylation via CYP2D6.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:7

    Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP2D6 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Paroxetine; Pupil; Tramadol

2010
Evaluation of tramadol on demand vs. daily paroxetine as a long-term treatment of lifelong premature ejaculation.
    The journal of sexual medicine, 2010, Volume: 7, Issue:8

    Topics: Adult; Analgesics, Opioid; Drug Administration Schedule; Egypt; Ejaculation; Follow-Up Studies; Humans; Libido; Long-Term Care; Male; Paroxetine; Penile Erection; Selective Serotonin Reuptake Inhibitors; Sexual Dysfunction, Physiological; Tramadol

2010

Other Studies

11 other study(ies) available for paroxetine and tramadol

ArticleYear
Nightmares and hallucinations after long-term intake of tramadol combined with antidepressants.
    Acta clinica Belgica, 1996, Volume: 51, Issue:3

    Topics: Aged; Analgesics, Opioid; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Dothiepin; Dreams; Hallucinations; Humans; Male; Paroxetine; Tramadol

1996
Serotonin syndrome attributed to tramadol addition to paroxetine therapy.
    International clinical psychopharmacology, 1997, Volume: 12, Issue:3

    Topics: Analgesics, Opioid; Drug Interactions; Humans; Male; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin; Tramadol

1997
Serotonin syndrome following the administration of tramadol with paroxetine.
    International journal of geriatric psychiatry, 1998, Volume: 13, Issue:5

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Antidepressive Agents, Second-Generation; Autonomic Nervous System Diseases; Central Nervous System Diseases; Depression; Drug Interactions; Female; Humans; Pain; Paroxetine; Selective Serotonin Reuptake Inhibitors; Syndrome; Tramadol

1998
[Possible serotoninergic syndrome associated with coadministration of paroxetine and tramadol].
    Medicina clinica, 2007, Mar-24, Volume: 128, Issue:11

    Topics: Aged; Aged, 80 and over; Algorithms; Analgesics, Opioid; Antidepressive Agents, Second-Generation; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Female; Humans; Iatrogenic Disease; Osteoarthritis; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Time Factors; Tramadol

2007
Severe serotonin toxicity and manic switch induced by combined use of tramadol and paroxetine.
    The Australian and New Zealand journal of psychiatry, 2007, Volume: 41, Issue:2

    Topics: Analgesics, Opioid; Bipolar Disorder; Depressive Disorder, Major; Drug Therapy, Combination; Female; Humans; Middle Aged; Pain; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Tramadol

2007
The majority of men with lifelong premature ejaculation prefer daily drug treatment: an observation study in a consecutive group of Dutch men.
    The journal of sexual medicine, 2007, Volume: 4, Issue:4 Pt 1

    Topics: Adult; Benzylamines; Clomipramine; Cohort Studies; Coitus; Dose-Response Relationship, Drug; Ejaculation; Humans; Male; Middle Aged; Naphthalenes; Netherlands; Paroxetine; Patient Satisfaction; Selective Serotonin Reuptake Inhibitors; Sexual Dysfunction, Physiological; Tramadol; Treatment Outcome

2007
Deaths involving serotonergic drugs.
    Forensic science international, 2010, May-20, Volume: 198, Issue:1-3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Australia; Cause of Death; Citalopram; Cyclohexanols; Female; Fluoxetine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Serotonin Agents; Sertraline; Tramadol; Venlafaxine Hydrochloride

2010
Pharmacological classification of herbal extracts by means of comparison to spectral EEG signatures induced by synthetic drugs in the freely moving rat.
    Journal of ethnopharmacology, 2013, Sep-16, Volume: 149, Issue:2

    Topics: Animals; Brain; Caffeine; Electroencephalography; Magnoliopsida; Methylphenidate; Paroxetine; Phenytoin; Plant Extracts; Rats; Tramadol

2013
Tramadol: Effects on sexual behavior in male rats are mainly caused by its 5-HT reuptake blocking effects.
    Neuropharmacology, 2017, Volume: 116

    Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Ejaculation; Male; Naloxone; Narcotic Antagonists; Paroxetine; Piperazines; Pyridines; Random Allocation; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Opioid, mu; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Sexual Behavior, Animal; Tramadol

2017
Impact of CYP2D6 Functional Allelic Variations on Phenoconversion and Drug-Drug Interactions.
    Clinical pharmacology and therapeutics, 2018, Volume: 104, Issue:1

    Topics: Adolescent; Adult; Alleles; Analgesics, Opioid; Antitussive Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Drug Interactions; Duloxetine Hydrochloride; Female; Genotype; Heterozygote; Homozygote; Humans; Male; Paroxetine; Pharmacogenomic Variants; Phenotype; Tramadol; Young Adult

2018
Identification of potential inhibitors, conformational dynamics, and mechanistic insights into mutant Kirsten rat sarcoma virus (G13D) driven cancers.
    Journal of cellular biochemistry, 2022, Volume: 123, Issue:9

    Topics: Humans; Kirsten murine sarcoma virus; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Paroxetine; Prospective Studies; Proto-Oncogene Proteins p21(ras); Tramadol

2022