Page last updated: 2024-08-23

paroxetine and piperidines

paroxetine has been researched along with piperidines in 292 studies

Research

Studies (292)

TimeframeStudies, this research(%)All Research%
pre-1990127 (43.49)18.7374
1990's123 (42.12)18.2507
2000's29 (9.93)29.6817
2010's13 (4.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jørgensen, OS; Mellerup, ET; Plenge, P1
Carli, M; Dewar, KM; Grondin, L; Lima, L; Reader, TA1
Dwork, A; Huang, YY; Parsons, B; Roxas, A; Stanley, M1
Katz, JL; Martello, AL; Martello, MB; Ricaurte, GA1
Chen, JC; Schnepper, PW; To, A; Volicer, L1
Culp, S; DeSouza, EB; Lehmann, J; Zaczek, R1
Andersson, A; Marcusson, J; Sundman, I1
Möller, HJ; Steinmeyer, EM1
Abraham, P; Carroll, FI; Cline, EJ; Dannals, RF; Kuhar, MJ; Lewin, AH; Ricaurte, GA; Scheffel, U1
Bach, FW; Gram, LF; Sindrup, SH1
Block, P; Fieve, RR; Peselow, ED; Robins, CJ; Sanfilipo, MP1
Artigas, F; Ortiz, J1
Dunbar, GC; Fuell, DL; Sheehan, D1
Edwards, E; Henn, FA; Houtten, PV; Kornrich, W1
Bloomer, JC; Haddock, RE; Lennard, MS; Tucker, GT; Woods, FR1
Difiglia, C; Fieve, RR; Peselow, ED; Sanfilipo, MP1
Emilsson, K; Hardebo, JE; Nystedt, S; Owman, C; Szabò, C1
DeVane, CL1
Dunbar, GC; Dunner, DL1
Kiev, A1
Boyer, WF; Feighner, JP3
Amsterdam, J; Clary, C; Fox, I; Rickels, K; Schweizer, E; Weise, C2
Claghorn, JL1
Glaudin, V; Smith, WT1
Fabre, LF1
Blumhardt, CL; Overweg, N; Shrivastava, RK; Shrivastava, SH1
Cohn, JB; Wilcox, CS1
Cohn, CK; Cohn, JB; Dunner, DL; Feighner, JP; Fieve, RR; Halikas, JP; Hartford, JT; Hearst, ED; Settle, EC; Walshe, T1
Blumhardt, CL; Boyer, WF1
Johnson, AM; Tulloch, IF1
Allen, A; Allen, GD; Brøsen, K; Cooper, SM; Gram, LF; Hallas, J; Mellows, G; Sindrup, SH; Skjelbo, E; Tasker, TC1
Brøsen, K; Gram, LF; Sindrup, SH1
Karnovsky, ML; Polanski, M1
Goodman, WK; McDougle, CJ; Price, LH1
McGuirk, J; Muscat, R; Willner, P1
Alouf, JE; Buckle, M; Cesura, A; Da Prada, M; Geoffroy, C; Launay, JM; Mutel, V1
Kuhs, H; Rolf, LH; Rudolf, GA; Schlake, HP1
Bell, J; Whitaker-Azmitia, PM; Zhang, XN1
Akbari, HM; Azmitia, EC; Kramer, HK; Spear, LP; Whitaker-Azmitia, PM1
Ben-Zeev, A; Lerer, B; Newman, ME1
Anzini, M; Cagnotto, A; Campiani, G; Cappelli, A; Skorupska, M; Vomero, S1
Colpaert, FC; Millan, MJ1
Bowery, NG; Johnson, AM; Nelson, DR; Palmer, KJ; Pratt, GD1
Battaglia, G; de Souza, EB; Kuhar, MJ; Sharkey, J1
Kelly, PA; McBean, DE; Sharkey, J1
Goromaru, T; Hashimoto, K3
Max, MB1
Arora, RC; Meltzer, HY; Nash, JF; Schreiber, MA1
Hill, DR; Stoessl, AJ1
Clissold, SP; Dechant, KL1
Garattini, S; Mennini, T1
Descarries, L; Dewar, KM; Grondin, L; Reader, TA1
Dannals, RF; Ravert, HT; Scheffel, U; Suehiro, M; Wagner, HN; Wilson, AA1
Mellerup, ET; Plenge, P6
Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH; Philip, A; Rahman, MA1
Edwards, E; Harkins, K; Henn, F; Wright, G1
Badawy, AA; Morgan, CJ1
Johnson, MP; Nichols, DE; Oberlender, R1
Boucly, P; Breton, P; Daoust, M; Ernouf, D; Legrand, E; Lhuintre, JP1
Esnaud, H; Graham, D; Langer, SZ1
Guan, XM; McKenna, DJ; Shulgin, AT1
Eglen, RM; Loury, DN; Michel, AD; Sharif, NA; Stefanich, E; Whiting, RL; Wong, EH1
Laursen, H; Mellerup, ET; Plenge, P2
Bengtsson, BO; Lundmark, J; Wålinder, J1
Elbaz, E; Glaser, R; Jensen, PN; Mikkelsen, EO; Poulsen, SH; Smith, DF1
Akunne, H; deCosta, BR; Jacobson, AE; Rice, KC; Rothman, RB1
Egashira, T; Goto, S; Yamanaka, Y1
Larsen, T; Manniche, PM; Morsing, I; Møller, SE; Nielsen, OA; Petersen, JS; Skausig, OB1
Beck-Nielsen, H; Gram, LF; Grodum, E; Sindrup, SH1
Cohn, JB; Dunbar, GC; Fabre, LF; Feighner, JP; Fieve, RR; Mendels, J; Shrivastava, RK1
Briley, M; Moret, C2
Casanova, MF; Chen, HT; Goldman, D; Kleinman, JE; Linnoila, M; Zito, M1
Dam, H; Lauritzen, L; Mellerup, ET; Plenge, P1
Anderer, P; Frey, R; Grünberger, J; Krupka, M; Saletu, B; See, WR1
Blier, P; Chaput, Y; de Montigny, C1
Almdal, TP; Bjerrum, K; Dalhoff, K; Keiding, S; Lund, J; Mengel, H1
Baldwin, D; Bullock, T; Montgomery, D; Montgomery, S1
Brewster, WK; Johnson, MP; Nichols, DE; Oberlender, R; Riggs, RM1
Hekmatpanah, CR; Peroutka, SJ1
Peroutka, SJ; Wagner, J1
Bird, ED; Crino, PB; Plager, MD; Vogt, BA1
Johnson, AM; Nelson, DR; Palmer, KJ1
Ricaurte, GA; Scheffel, U1
Bech, P; Bjerrum, H; Butler, B; Bøjholm, S; Folker, H; Gram, LF; Larsen, JK; Lauritzen, L; Loldrup, D; Møller, SE1
Foy, B; Hepner, A; Hrdina, PD; Summers, RJ1
Insel, TR; Winslow, JT1
Crino, PB; Vogt, BA; Volicer, L; Wiley, RG1
Koe, BK; Lebel, LA; Welch, WM1
Johnson, MP; Nichols, DE2
Briley, M; Chopin, P; Moret, C1
Cool, DR; Ganapathy, V; Leibach, FH1
Aronstam, RS; Introna, RP; Martin, DC1
Appel, NM; Contrera, JF; De Souza, EB; Mitchell, WM1
Fekkes, D; Klompenhouwer, JL; Moleman, P; Mulder, PG; Pepplinkhuizen, L; van Hulst, AM1
Cheetham, SC; Crompton, MR; De Paermentier, F; Horton, RW; Katona, CL; Lawrence, KM3
Cohn, JB; Crowder, JE; Ryan, PJ; Wilcox, CS1
Cool, DR; Ganapathy, V; Liebach, FH1
Strijewski, A; Tang, SW1
Brøsen, K; Eshøj, O; Gram, LF; Mogensen, EF; Sindrup, SH1
Kuhs, H; Rudolf, GA2
Mellerup, ET; Nielsen, M; Plenge, P2
Rickels, K; Schweizer, E1
Westwick, F1
Bertocci, B; Cesura, AM; Da Prada, M1
Quartermain, D; Shemer, AV; Whitaker-Azmitia, PM1
Egashira, T; Goto, S; Murayama, F; Yamanaka, Y1
Blier, P; Galzin, AM; Langer, SZ1
Battaglia, G; De Souza, EB; Kuhar, MJ; Molliver, ME; O'Hearn, E; Yeh, SY1
Brunello, N; Galimberti, R; Racagni, G; Riva, M; Rovescalli, AC1
Herrick-Davis, K; Maisonneuve, IM; Titeler, M1
Hartig, PR; Scheffel, U1
Edwards, JG; Goldie, A; Papayanni-Papasthatis, S1
Bäckström, I; Bergström, M; Marcusson, J1
Buus Lassen, J1
Koshikawa, N; Maruyama, Y; Stephenson, JD1
De Oliveira, AM; Langer, SZ; Schoemaker, H; Segonzac, A1
Andersson, A; Bäckström, I; Marcusson, JO1
Galzin, AM; Langer, SZ; Rocca, P1
Anzini, M; Cagnotto, A; Cappelli, A; Garofalo, A; Vomero, S1
Furuya, Y; Iwasaki, K; Minamoto, Y; Miyamoto, K; Ohno, M; Shibata, S; Shimazoe, T; Ueki, S; Watanabe, S; Yamamoto, T1
Bannister, SJ; Houser, VP; Hulse, JD; Kisicki, JC; Rasmussen, JG1
Montgomery, SA1
Edwards, JG; Goldie, A; Papayanni-Papasthatis, S; Punter, J; Sedgwick, EM1
Lassen, JB1
Fourie, J; Gagiano, CA; Le Roux, JF; Müller, PG1
Archambault, JC; Chabannes, JP; Clerc, G; Desvilles, M; Guibert, M; Guillibert, E; Pagot, R; Pelicier, Y; Poisat, JL; Thobie, Y1
Dunbar, GC1
Byrne, MM1
Johnson, AM1
Mertens, C; Pintens, H2
Bascara, L1
Miller, SM; Murtagh, M; Naylor, GJ; Winslow, G1
Brune, GG; Husstedt, IW; Kuhs, H; Rudolf, GA1
Bosse, T; Brune, GG; Kuhs, H; Rolf, LH; Rudolf, GA; Schlake, HP; Schuhknecht, E1
Kaye, CM; Link, CG; Tasker, TC; Zussman, BD1
Buscher, G; Dierdorf, HD; Greb, WH; von Schrader, HW; Wolf, D1
Johnson, AM; Nelson, DR; Thomas, DR2
Haddock, RE; Johnson, AM; Langley, PF; Nelson, DR; Pope, JA; Thomas, DR; Woods, FR1
Cain, CR; Hamilton, TC; Norton, J; Petersen, EN; Poyser, RH; Thormählen, D1
Hakansson, S; Kelvin, AS1
Kelvin, AS; Mitchell, ID; White, DJ1
Baldwin, JA; Davidson, EJ; Pritchard, AL; Ridings, JE1
Dewdney, JM; Edwards, RG; Henderson, DC; Weston, BJ2
de Vries, J; Deijen, JB; Loriaux, SM; Orlebeke, JF1
Dana-Haeri, J; Sinclair, AJ; Warrington, SJ1
Harrison, C; Hindmarch, I1
Jackson, D; McClelland, GR; Raptopoulos, P2
Hassan, SM; Turner, P; Wainscott, G2
Cooper, SM; Jackson, D; Loudon, JM; McClelland, GR; Raptopoulos, P1
Laruelle, M; Maloteaux, JM1
Greb, WH; Haddock, RE; Kaye, CM; Langley, PF; Mellows, G; Tasker, TC; Zussman, BD1
Fjord-Larsen, T; Lundmark, J; Manniche, PM; Mengel, H; Møller-Nielsen, EM; Pauser, H; Scheel Thomsen, I; Wålinder, J1
Dunbar, GC; Fellerer, K; Hebenstreit, GF; Zentz, A; Zöchling, R1
Allen, EA; Bayer, AJ; Byrne, MM; Clarkson, A; Horan, M; Roberts, NA; Routledge, PA; Swift, CG; Zussman, BD1
Ghose, K1
Byrne, MM; Clarkson, A; Doyle, GD; Kelly, JG; Laher, M; Zussman, BD1
Dierdorf, HD; Eckl, KM; Greb, WH; Krastev, Z; Maleev, A; Terziivanov, D; Vlahov, V; Wolf, D1
Haddock, RE; Jackson, D; Woods, FR1
Buscher, G; Dierdorf, HD; Greb, WH; Köster, FE; Mellows, G; Wolf, D1
Brett, MA; Buscher, G; Dierdorf, HD; Greb, WH; Mellows, G; von Schrader, HW; Wolf, D; Zussman, BD1
Esnaud, H; Graham, D; Habert, E; Langer, SZ1
Barouche, F; Fieve, RR; Filippi, AM; Goodnick, P; Peselow, ED2
Barouche, F; Fieve, RR; Filippi, AM; Goodnick, P; Peselow, ED; Stanley, M1
Hurt, SD; Peroutka, SJ; Schmidt, AW1
Andersson, A; Marcusson, J1
Beani, L; Bianchi, C; Siniscalchi, A1
Hekmatpanah, CR; McKenna, DJ; Peroutka, SJ1
Gleiter, CH; Nutt, DJ2
Galzin, AM; Langer, SZ; Moret, C; Verzier, B1
Cross, AJ; Reynolds, GP; Slater, P1
Honoré, PL; Honoré, T; Mellerup, ET; Plenge, P1
Dubicki, W; Goudie, AJ; Leathley, M1
Claustre, Y; Graham, D; Habert, E; Langer, SZ; Tahraoui, L1
Koshikawa, F; Koshikawa, N; Stephenson, JD1
Fuller, RW1
Asberg, M; Eriksson, B; Mårtensson, B; Träskman-Bendz, L; Wägner, A1
Agid, Y; Cash, R; Raisman, R1
Smith, DF1
Hamilton, TC; Norton, J; Poyser, RH; Thormählen, D1
Graham, D; Habert, E; Langer, SZ1
Adam, K; Oswald, I1
Langer, SZ; Schoemaker, H; Segonzac, A1
Mellerup, ET; Plenge, P; Rafaelsen, OJ1
Graham, D; Langer, SZ; Tahraoui, L1
Brett, MA; Coates, PE; Dierdorf, HD; Zussman, BD1
Aoki, S; Kobayashi, M; Koshikawa, N; Stephenson, JD1
Ishikura, Y; Ono, H; Yokota, S1
Galzin, AM; Langer, SZ1
Burki, HR; Kleinlogel, H1
Bergström, M; Eriksson, K; Marcusson, JO; Ross, SB1
Furuya, Y; Man'no, K; Ohno, M; Ohta, H; Sugihara, K; Tani, Y; Ueki, S; Watanabe, S1
Laruelle, M; Maloteaux, JM; Vanisberg, MA1
Eriksson, K; Marcusson, J1
Kobayashi, M; Koshikawa, N; Maruyama, Y; Mori, E; Nomura, H; Oka, K; Stephenson, JD1
De Souza, EB; Kuyatt, BL1
Cortés, R; Palacios, JM; Pazos, A; Probst, A; Soriano, E1
Yoshida, Y1
D'haenen, H; De Waele, M; Leysen, JE1
Barnas, C; Fleischhacker, WW; Hinterhuber, H; Mair, M; Schifferle, I; Schubert, H; Stuppäck, C; Unterweger, B; Wömhart, L1
Magnussen, I1
Galzin, AM; Langer, SZ; Lee, CR; Taranger, MA1
Ichida, S; Manno, K; Miki, N; Sugihara, K; Tanigaki, N; Yoshida, H1
Galzin, AM; Langer, SZ; Loo, H; Poirier, MF; Sechter, D; Zarifian, E1
Laursen, AL; le Fèvre Honoré, P; Mikkelsen, PL; Rasmussen, S1
Koshikawa, N; Smokcum, RW; Stephenson, JD1
Battegay, R; Hager, M; Rauchfleisch, U1
Engbaek, F; Lademann, A; Magnussen, I; Mondrup, K; Olivarius, BD1
Gram, LF; Kristensen, CB; Lund, J; Mengel, H; Pedersen, OL; Thayssen, P1
Børup, C; le Fèvre Honoré, P; Meidahl, B; Petersen, IM; Vangtorp, A1
Göthert, M; Schlicker, E1
Engelstoft, M; Mellerup, ET; Plenge, P1
McClelland, GR; Raptopoulos, P1
Clausing, R; Göthert, M; Schlicker, E1
Lassen, JB; Lund, J; Søndergaard, I1
Hyttel, J; Sánchez, C1
Härtter, S; Hermes, B; Hiemke, C; Szegedi, A1
Feldtrauer, JJ; Germer, M; Graf, T; Howald, H; Waldmeier, PC1
Earley, B; Faherty, CJ; Leonard, BE1
Stein, MB1
Carrier, L1
Hansen, JB; Kristiansen, JE1
Rojas-Fernandez, C1
Amat, M; Bosch, J; Cantó, M; Hidalgo, J; Llor, N; Luque, J; Miravitlles, C; Molins, E; Orozco, M; Pérez, M1
Schneier, FR1
Beak, P; Curtis, MD; Johnson, TA1
Blier, P; Szabo, ST1
Bayod, M; Brieva, R; de Gonzalo, G; Gotor, V; Sánchez, VM2
Navrátilová, H; Potácek, M1
Bour, P; Navrátilová, H; Setnicka, V; Urbanová, M; Volka, K1
Gray, K; Newson, M; Pei, Q; Sharp, T; Sprakes, M; Tordera, R1
Ahmad, LJ; Atkinson, ST; Hertel, LW; Honigschmidt, NA; Koch, DJ; Kohn, TJ; Nelson, DL; Rocco, VP; Shaw, J; Spinazze, PG; Takeuchi, K; Threlkeld, PG; Wainscott, DB; Wong, DT1
Hansen, JB; Kaatz, GW; Kristiansen, JE; Moudgal, VV; Seo, SM1
Ahmad, LJ; Atkinson, ST; Hertel, LW; Honigschmidt, NA; Kohn, TJ; Nelson, DL; Rocco, VP; Shaw, J; Spinazze, PG; Takeuchi, K; Threlkeld, PG; Wainscott, DB; Wong, DT1
De Felipe, C; Froger, N; Gardier, AM; Guiard, BP; Guilloux, JP; Hunt, SP; Lanfumey, L; Przybylski, C; Seif, I1
Kaatz, GW; Kerns, RJ; Wei, P1
Cossy, J1
Owen, JC; Whitton, PS1
Ihara, M; Nishida, N; Takasu, K; Tomimura, A1
Froger, N; Gardier, AM; Guiard, BP; Hamon, M; Lanfumey, L1
Bourin, M; Chenu, F; Gardier, AM; Guiard, BP1
de Boissezon, X; de Boysson, C; Démonet, JF; Peran, P1
Arban, R; Atkinson, PJ; Dawson, LA; Duxon, MS; Hagan, JJ; Melotto, S; Price, GW; Starr, KR; Upton, N; Watson, JM1
Bower, JF; Gallagher, T; Riis-Johannessen, T; Szeto, P; Whitehead, AJ1
Gross, G; Groth, I; Jongen-Relo, A; Rex, A; Wicke, KM1
Baker, B; Kolluri, S; Krams, M; Landen, JW; Menniti, FS; Preskorn, SH1
Aznar, S; Knudsen, GM; Licht, CL; Marcussen, AB; Overstreet, DH; Wegener, G1
Hashimoto, K1
Dehpour, AR; Ebrahimi, F; Ghasemi, M; Montaser-Kouhsari, L; Nezami, BG; Shafaroodi, H1
Knudsen, GM; Licht, CL; Sharp, T1
Casarotto, PC; Gomes, FV; Guimarães, FS; Resstel, LB1
Asukai, N; Haraguchi, A; Hori, T; Ikeda, K; Ogai, Y; Senoo, E1
Baguley, DM; Dewit, O; Fina, P; Inamdar, A; Kitchiner, P; Koch, A; McFerran, DJ; Merlo-Pich, E; Roberts, C1
Archer, G; Bellew, K; Bettica, P; Bryson, H; Bye, A; Fernandes, S; Krishnan, KR; Ratti, E; Squassante, L; Trist, D; Zamuner, S1
Hochfeld, M; Meng, X; Potkin, SG; Preskorn, S1
Devalankar, DA; Karabal, PU; Sudalai, A1
Achrainer, F; Šakić, D; Vrček, V; Zipse, H1
Preskorn, SH1
Li, F; Ling, Z; Liu, C; Liu, L; Liu, X; Shu, N; Xu, D; Zhang, M; Zhong, Z1
Hayama, K; Ito, H; Kubota, K; Watanabe, Y1
Bernardo, BC; Blaxall, BC1
Dudka, J; Poleszak, E; Serefko, A; Stasiuk, W; Świąder, K; Szopa, A; Wlaź, P; Wyska, E1

Reviews

24 review(s) available for paroxetine and piperidines

ArticleYear
Melancholic/endogenous depression and response to somatic treatment and placebo.
    The American journal of psychiatry, 1992, Volume: 149, Issue:10

    Topics: Antidepressive Agents; Depressive Disorder; Double-Blind Method; Fluoxetine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Placebos; Prospective Studies; Psychiatric Status Rating Scales; Treatment Outcome

1992
Pharmacokinetics of the selective serotonin reuptake inhibitors.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: 1-Naphthylamine; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Serotonin Antagonists; Sertraline

1992
Optimal dose regimen for paroxetine.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Administration, Oral; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Multicenter Studies as Topic; Paroxetine; Piperidines

1992
An overview of paroxetine.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Humans; Nausea; Paroxetine; Piperidines; Serotonin Antagonists

1992
The safety profile of paroxetine.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Adult; Aged; Antidepressive Agents; Bipolar Disorder; Cardiovascular System; Clinical Trials as Topic; Depressive Disorder; Drug Interactions; Electrocardiography; Female; Humans; Male; Middle Aged; Neurocognitive Disorders; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Psychomotor Performance; Sleep

1992
The pharmacologic profile of paroxetine, a new selective serotonin reuptake inhibitor.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: 1-Naphthylamine; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; In Vitro Techniques; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Serotonin Antagonists; Sertraline

1992
Pharmacotherapy of obsessive compulsive disorder.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: 1-Naphthylamine; Antidepressive Agents; Clomipramine; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Neurotransmitter Uptake Inhibitors; Obsessive-Compulsive Disorder; Paroxetine; Piperidines; Serotonin; Sertraline

1992
Paroxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness.
    Drugs, 1991, Volume: 41, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Clomipramine; Depressive Disorder; Drug Evaluation; Drug Tolerance; Humans; Imipramine; Paroxetine; Piperidines; Serotonin Antagonists

1991
[Neurobiology of tianeptine. A new pharmaceutic agent].
    Presse medicale (Paris, France : 1983), 1991, Nov-14, Volume: 20, Issue:37

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cerebral Cortex; Cyclic AMP; Hippocampus; Hydroxyindoleacetic Acid; Hypothalamus; Injections, Intraperitoneal; Paroxetine; Piperidines; Rats; Serotonin; Thiazepines

1991
5-HT reuptake inhibitors, tricyclic antidepressants and suicidal behaviour.
    International clinical psychopharmacology, 1991, Volume: 6 Suppl 3

    Topics: Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Fluoxetine; Fluvoxamine; Humans; Mianserin; Paroxetine; Piperidines; Serotonin Antagonists; Suicide; Suicide Prevention

1991
Clinical overview of serotonin reuptake inhibitors.
    The Journal of clinical psychiatry, 1990, Volume: 51 Suppl B

    Topics: 1-Naphthylamine; Antidepressive Agents, Tricyclic; Depressive Disorder; Fluoxetine; Humans; Paroxetine; Piperidines; Serotonin Antagonists; Sertraline; Zimeldine

1990
Depression and selective serotonin reuptake inhibitors.
    British journal of hospital medicine, 1990, Volume: 44, Issue:5

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Depression; Fluoxetine; Humans; Imipramine; Meta-Analysis as Topic; Middle Aged; Multicenter Studies as Topic; Paroxetine; Piperidines; Serotonin Antagonists

1990
New antidepressants and 5-HT uptake inhibitors.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Depressive Disorder; Humans; Long-Term Care; Paroxetine; Piperidines; Serotonin Antagonists

1989
An interim overview of the safety and tolerability of paroxetine.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Clinical Trials as Topic; Humans; Paroxetine; Piperidines; Serotonin Antagonists

1989
An overview of the animal pharmacology of paroxetine.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Animals; Antidepressive Agents; Arousal; Brain; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin Antagonists

1989
A review of the metabolism and pharmacokinetics of paroxetine in man.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Depressive Disorder; Drug Interactions; Humans; Metabolic Clearance Rate; Paroxetine; Piperidines; Serotonin Antagonists

1989
Biochemical pharmacology of the serotonin system.
    Advances in neurology, 1986, Volume: 43

    Topics: Alanine; Brain; Citalopram; Clomipramine; Fenfluramine; Fluoxetine; Fluvoxamine; Humans; Monoamine Oxidase Inhibitors; Neurons; Oximes; p-Chloroamphetamine; Paroxetine; Piperidines; Propylamines; Receptors, Serotonin; Reserpine; Serotonin; Serotonin Antagonists; Synapses; Tetrabenazine; Zimeldine

1986
Therapeutic effects of serotonin uptake inhibitors in depression.
    The Journal of clinical psychiatry, 1986, Volume: 47 Suppl

    Topics: 5-Hydroxytryptophan; Alanine; Citalopram; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Propylamines; Serotonin; Serotonin Antagonists; Trazodone; Zimeldine

1986
Studies on the serotonin transporter in platelets.
    Experientia, 1988, Feb-15, Volume: 44, Issue:2

    Topics: Animals; Antidepressive Agents, Tricyclic; Binding Sites; Blood Platelets; Carrier Proteins; Humans; Imipramine; Paroxetine; Piperidines; Serotonin Antagonists

1988
Medication treatments for panic disorder and social phobia.
    Depression and anxiety, 1998, Volume: 7, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Benzamides; Benzodiazepines; Citalopram; Clinical Trials as Topic; Clomipramine; Clonazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Moclobemide; Monoamine Oxidase Inhibitors; Panic Disorder; Paroxetine; Piperidines; Recurrence; Selective Serotonin Reuptake Inhibitors; Social Behavior Disorders

1998
Treatment of social phobia with antidepressants.
    The Journal of clinical psychiatry, 2001, Volume: 62 Suppl 1

    Topics: Antidepressive Agents; Controlled Clinical Trials as Topic; Drug Approval; Humans; Moclobemide; Monoamine Oxidase Inhibitors; Paroxetine; Phenelzine; Phobic Disorders; Piperidines; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; United States

2001
Selective methodologies for the synthesis of biologically active piperidinic compounds.
    Chemical record (New York, N.Y.), 2005, Volume: 5, Issue:2

    Topics: Alkaloids; Arginine; Chemistry; Dioxoles; Paroxetine; Pipecolic Acids; Piperidines; Pyrrolidines; Sulfonamides

2005
Pharmacotherapy of aphasia: myth or reality?
    Brain and language, 2007, Volume: 102, Issue:1

    Topics: Amphetamine; Aphasia; Bromocriptine; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dopamine Agents; Fluoxetine; GABA Agonists; Humans; Indans; Neuroprotective Agents; Paroxetine; Physostigmine; Piperidines; Piracetam; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin; Stroke; Zolpidem

2007
From Bench to Bedside: New Approaches to Therapeutic Discovery for Heart Failure.
    Heart, lung & circulation, 2016, Volume: 25, Issue:5

    Topics: Angiotensin Receptor Antagonists; Cardiac Myosins; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclohexanes; G-Protein-Coupled Receptor Kinase 2; Heart Failure; Humans; Neprilysin; Oximes; Paroxetine; Piperidines; RNA, Untranslated; Xanthenes

2016

Trials

63 trial(s) available for paroxetine and piperidines

ArticleYear
Facet theoretic analysis of the Hamilton-D scale.
    Journal of affective disorders, 1992, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Factor Analysis, Statistical; Female; Humans; Male; Middle Aged; Models, Statistical; Paroxetine; Personality Inventory; Piperidines; Prospective Studies; Psychometrics; Serotonin Antagonists

1992
Plasma beta-endorphin is not affected by treatment with imipramine or paroxetine in patients with diabetic neuropathy symptoms.
    The Clinical journal of pain, 1992, Volume: 8, Issue:2

    Topics: Adult; Aged; Antidepressive Agents; beta-Endorphin; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Paroxetine; Piperidines

1992
Sociotropy and autonomy: relationship to antidepressant drug treatment response and endogenous-nonendogenous dichotomy.
    Journal of abnormal psychology, 1992, Volume: 101, Issue:3

    Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Humans; Imipramine; Individuality; Internal-External Control; Interpersonal Relations; Male; Oximes; Paroxetine; Piperidines; Serotonin Antagonists

1992
The effect of paroxetine on anxiety and agitation associated with depression.
    Psychopharmacology bulletin, 1992, Volume: 28, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Anxiety; Depressive Disorder; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales

1992
Melancholic/endogenous depression and response to somatic treatment and placebo.
    The American journal of psychiatry, 1992, Volume: 149, Issue:10

    Topics: Antidepressive Agents; Depressive Disorder; Double-Blind Method; Fluoxetine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Placebos; Prospective Studies; Psychiatric Status Rating Scales; Treatment Outcome

1992
A double-blind, placebo-controlled study of paroxetine in depressed outpatients.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drugs, Investigational; Humans; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Psychiatric Status Rating Scales

1992
The efficacy and safety of paroxetine compared with placebo in outpatients with major depression.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Female; Humans; Male; Middle Aged; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Psychiatric Status Rating Scales

1992
The safety and efficacy of paroxetine compared with placebo in a double-blind trial of depressed outpatients.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Psychiatric Status Rating Scales

1992
A placebo-controlled trial of paroxetine in the treatment of major depression.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Female; Humans; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Patient Dropouts; Piperidines; Placebos; Psychiatric Status Rating Scales; Suicide; Time Factors

1992
A 6-week, double-blind trial of paroxetine, imipramine, and placebo in depressed outpatients.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Patient Dropouts; Piperidines; Placebos; Psychiatric Status Rating Scales

1992
Paroxetine in the treatment of depression: a comparison with imipramine and placebo.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Adolescent; Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Patient Dropouts; Piperidines; Placebos; Psychiatric Status Rating Scales

1992
A double-blind comparison of paroxetine, imipramine, and placebo in major depression.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Patient Dropouts; Piperidines; Placebos; Prospective Studies; Psychiatric Status Rating Scales

1992
Paroxetine in major depression: a double-blind trial with imipramine and placebo.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Adult; Antidepressive Agents; Anxiety Disorders; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Prospective Studies

1992
Two combined, multicenter double-blind studies of paroxetine and doxepin in geriatric patients with major depression.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Age Factors; Aged; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Doxepin; Female; Humans; Male; Middle Aged; Neurotransmitter Uptake Inhibitors; Paroxetine; Patient Dropouts; Piperidines; Psychiatric Status Rating Scales

1992
Relationship between parameters of serotonin transport and antidepressant plasma levels or therapeutic response in depressive patients treated with paroxetine and amitriptyline.
    Acta psychiatrica Scandinavica, 1992, Volume: 85, Issue:5

    Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Platelets; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Receptors, Serotonin; Serotonin; Serotonin Antagonists

1992
Novel selective serotonin reuptake inhibitors, Part II.
    The Journal of clinical psychiatry, 1992, Volume: 53, Issue:6

    Topics: Adult; Aged; Ambulatory Care; Depressive Disorder; Humans; Imipramine; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Recurrence; Serotonin; Serotonin Antagonists

1992
Paroxetine and imipramine treatment of depressive patients in a controlled multicentre study with plasma amino acid measurements.
    Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3

    Topics: Amino Acids; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Imipramine; Male; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Serotonin Antagonists

1991
A comparison of paroxetine, imipramine and placebo in depressed out-patients.
    The British journal of psychiatry : the journal of mental science, 1991, Volume: 159

    Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Paroxetine; Personality Tests; Piperidines; Serotonin Antagonists

1991
Sleep laboratory studies on the single-dose effects of serotonin reuptake inhibitors paroxetine and fluoxetine on human sleep and awakening qualities.
    Sleep, 1991, Volume: 14, Issue:5

    Topics: Adult; Arousal; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electroencephalography; Female; Fluoxetine; Humans; Male; Middle Aged; Monitoring, Physiologic; Paroxetine; Piperidines; Serotonin Antagonists; Sleep Stages; Wakefulness

1991
Plasma ratio tryptophan/neutral amino acids in relation to clinical response to paroxetine and clomipramine in patients with major depression.
    Journal of affective disorders, 1990, Volume: 18, Issue:1

    Topics: Adult; Aged; Amino Acids; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists; Tryptophan

1990
Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. Danish University Antidepressant Group.
    Journal of affective disorders, 1990, Volume: 18, Issue:4

    Topics: Adult; Antidepressive Agents; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Multicenter Studies as Topic; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Serotonin Antagonists

1990
A placebo- and imipramine-controlled study of paroxetine.
    Psychopharmacology bulletin, 1990, Volume: 26, Issue:2

    Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Paroxetine; Piperidines; Psychiatric Status Rating Scales

1990
The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms.
    Pain, 1990, Volume: 42, Issue:2

    Topics: Depression; Desipramine; Diabetic Neuropathies; Humans; Imipramine; Nervous System; Osmolar Concentration; Paroxetine; Piperidines; Serotonin Antagonists; Time Factors

1990
Cardiovascular effects of paroxetine.
    Psychopharmacology, 1990, Volume: 102, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Pressure; Double-Blind Method; Electrocardiography; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Paroxetine; Piperidines

1990
Effect of paroxetine on the electrocardiogram.
    Psychopharmacology, 1989, Volume: 97, Issue:1

    Topics: Adult; Calcium; Electrocardiography; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Paroxetine; Piperidines; Posture; Potassium

1989
A placebo-controlled, double-blind, clinical trial of paroxetine in depressed outpatients.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists

1989
The effect of paroxetine on the electroencephalogram, electrocardiogram, and blood pressure.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Arousal; Blood Pressure; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Electrocardiography; Electroencephalography; Heart Rate; Humans; Paroxetine; Piperidines; Serotonin Antagonists

1989
Paroxetine in the treatment of depression: a comparison with imipramine and placebo.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Imipramine; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists

1989
The therapeutic efficacy of paroxetine: (a) an open study in patients with major depression not responding to antidepressants; (b) a double-blind comparison with amitriptyline in depressed outpatients.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Aged; Antidepressive Agents; Clomipramine; Depressive Disorder; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists

1989
A double-blind, multicentre study of paroxetine versus clomipramine in depressed elderly patients.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Aged; Antidepressive Agents; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists

1989
An interim overview of the safety and tolerability of paroxetine.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Clinical Trials as Topic; Humans; Paroxetine; Piperidines; Serotonin Antagonists

1989
Meta-analysis of early phase II studies with paroxetine in hospitalized depressed patients.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drug Evaluation; Female; Hospitals, Psychiatric; Humans; Male; Meta-Analysis as Topic; Middle Aged; Paroxetine; Piperidines; Randomized Controlled Trials as Topic; Serotonin Antagonists

1989
A double-blind, multicentre study of paroxetine and mianserin in depression.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Bipolar Disorder; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Mianserin; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Serotonin Antagonists

1989
A double-blind study to compare the effectiveness and tolerability of paroxetine and amitriptyline in depressed patients.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Amitriptyline; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists

1989
A double-blind comparison of paroxetine and placebo in the treatment of depressed patients in a psychiatric outpatient clinic.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists

1989
A double-blind study of the comparative antidepressant effect of paroxetine and amitriptyline.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Amitriptyline; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Humans; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists

1989
Platelet 5-HT transport in depressed patients under double-blind treatment with paroxetine versus amitriptyline.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Platelets; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Paroxetine; Piperidines; Randomized Controlled Trials as Topic; Serotonin; Serotonin Antagonists

1989
The effects of paroxetine and maprotiline on mood, perceptual-motor skills, and eye movements in healthy volunteers.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Affect; Anthracenes; Antidepressive Agents; Clinical Trials as Topic; Double-Blind Method; Eye Movements; Female; Humans; Male; Maprotiline; Paroxetine; Piperidines; Psychomotor Performance; Serotonin Antagonists

1989
Cardiovascular and psychomotor effects of repeated doses of paroxetine: a comparison with amitriptyline and placebo in healthy men.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Amitriptyline; Antidepressive Agents; Arousal; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Heart Conduction System; Heart Rate; Humans; Male; Paroxetine; Piperidines; Psychomotor Performance; Randomized Controlled Trials as Topic; Serotonin Antagonists

1989
The effects of paroxetine and other antidepressants in combination with alcohol on psychomotor activity related to car driving.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Alcohol Drinking; Antidepressive Agents; Arousal; Automobile Driving; Ethanol; Female; Humans; Paroxetine; Piperidines; Psychomotor Performance; Randomized Controlled Trials as Topic; Reaction Time; Serotonin Antagonists

1989
The clinical pharmacology of paroxetine in healthy subjects.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Administration, Oral; Adult; Antidepressive Agents; Arousal; Clinical Trials as Topic; Double-Blind Method; Humans; Male; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists

1989
Paroxetine: lack of effect on the tyramine pressor response in man.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents; Arousal; Blood Pressure; Double-Blind Method; Humans; Male; Norepinephrine; Paroxetine; Piperidines; Randomized Controlled Trials as Topic; Serotonin Antagonists; Tyramine

1989
The effect of paroxetine on the quantitative EEG.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Amitriptyline; Antidepressive Agents; Arousal; Cerebral Cortex; Clinical Trials as Topic; Electroencephalography; Evoked Potentials; Female; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists

1989
The psychomotor effects of paroxetine alone and in combination with haloperidol, amylobarbitone, oxazepam, or alcohol.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Amobarbital; Antidepressive Agents; Arousal; Double-Blind Method; Ethanol; Female; Haloperidol; Humans; Male; Middle Aged; Oxazepam; Paroxetine; Piperidines; Psychomotor Performance; Randomized Controlled Trials as Topic; Reaction Time; Serotonin Antagonists

1989
Paroxetine: pharmacokinetic and antidepressant effect in the elderly.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Aged; Aged, 80 and over; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Serotonin Antagonists

1989
A pharmacokinetic dose titration study in adult and elderly depressed patients.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Aged; Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists

1989
The pharmacokinetics of paroxetine in elderly depressed patients.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Aged; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists

1989
The pharmacokinetics of paroxetine in renal impairment.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Female; Humans; Kidney Failure, Chronic; Kidney Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists

1989
The effect of liver enzyme inhibition by cimetidine and enzyme induction by phenobarbitone on the pharmacokinetics of paroxetine.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Clinical Trials as Topic; Enzyme Induction; Enzymes; Half-Life; Humans; Male; Microsomes, Liver; Paroxetine; Phenobarbital; Piperidines; Serotonin Antagonists

1989
Absorption of paroxetine under various dietary conditions and following antacid intake.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Administration, Oral; Adult; Aluminum Hydroxide; Animals; Antidepressive Agents; Clinical Trials as Topic; Dietary Fats; Feeding Behavior; Humans; Intestinal Absorption; Male; Milk; Paroxetine; Piperidines; Serotonin Antagonists

1989
The short- and long-term efficacy of paroxetine HCl: A. Data from a 6-week double-blind parallel design trial vs. imipramine and placebo.
    Psychopharmacology bulletin, 1989, Volume: 25, Issue:2

    Topics: Antidepressive Agents; Depressive Disorder; Double-Blind Method; Humans; Imipramine; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic

1989
The short- and long-term efficacy of paroxetine HCl: B. Data from a double-blind crossover study and from a year-long term trial vs. imipramine and placebo.
    Psychopharmacology bulletin, 1989, Volume: 25, Issue:2

    Topics: Antidepressive Agents; Depressive Disorder; Double-Blind Method; Humans; Imipramine; Paroxetine; Piperidines; Randomized Controlled Trials as Topic

1989
The predictive value of the dexamethasone suppression test. A placebo-controlled study.
    The British journal of psychiatry : the journal of mental science, 1989, Volume: 155

    Topics: Adult; Ambulatory Care; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Dexamethasone; Double-Blind Method; Female; Humans; Hydrocortisone; Imipramine; Male; Middle Aged; Paroxetine; Piperidines; Placebos; Predictive Value of Tests; Psychiatric Status Rating Scales

1989
Effects of paroxetine on human sleep.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:1

    Topics: Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Sleep; Sleep, REM

1986
Paroxetine in the treatment of depression. A double-blind multicenter study versus mianserin.
    Acta psychiatrica Scandinavica, 1988, Volume: 77, Issue:6

    Topics: Adult; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Mianserin; Paroxetine; Piperidines; Psychiatric Status Rating Scales

1988
Paroxetine in the treatment of depression--a randomized comparison with amitriptyline.
    Acta psychiatrica Scandinavica, 1985, Volume: 71, Issue:3

    Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Random Allocation; Serotonin Antagonists

1985
Double-blind comparative study of paroxetine and amitriptyline in depressed patients of a university psychiatric outpatient clinic (pilot study).
    Neuropsychobiology, 1985, Volume: 13, Issue:1-2

    Topics: Adolescent; Adult; Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales

1985
EEG and blood level of the potential antidepressant paroxetine after a single oral dose to normal volunteers.
    Psychopharmacology, 1984, Volume: 83, Issue:4

    Topics: Adult; Antidepressive Agents; Electroencephalography; Humans; Kinetics; Male; Paroxetine; Piperidines

1984
Serotonin uptake inhibition by the monoamine oxidase inhibitor brofaromine.
    Biological psychiatry, 1993, Mar-01, Volume: 33, Issue:5

    Topics: Adult; Depressive Disorder; Homovanillic Acid; Humans; Male; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Placebos; Selective Serotonin Reuptake Inhibitors

1993
An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.
    Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:6

    Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Drug Resistance; Excitatory Amino Acid Antagonists; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Receptors, N-Methyl-D-Aspartate; Research Design; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Time Factors; Treatment Failure; Young Adult

2008
A randomized, controlled study comparing the effects of vestipitant or vestipitant and paroxetine combination in subjects with tinnitus.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2011, Volume: 32, Issue:5

    Topics: Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Fluorobenzenes; Humans; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Tinnitus; Treatment Outcome

2011
Results from 2 randomized, double-blind, placebo-controlled studies of the novel NK1 receptor antagonist casopitant in patients with major depressive disorder.
    Journal of clinical psychopharmacology, 2011, Volume: 31, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Paroxetine; Piperazines; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome

2011
A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.
    Journal of clinical psychopharmacology, 2013, Volume: 33, Issue:1

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dibenzothiazepines; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Electrocardiography; Enzyme Inhibitors; Female; Genotype; Heart Rate; Humans; Isoxazoles; Ketoconazole; Linear Models; Long QT Syndrome; Male; Middle Aged; Paroxetine; Pharmacogenetics; Phenotype; Piperazines; Piperidines; Quetiapine Fumarate; Thiazoles; United States; Young Adult

2013

Other Studies

207 other study(ies) available for paroxetine and piperidines

ArticleYear
Lithium treatment regimens induce different changes in [3H]paroxetine binding protein and other rat brain proteins.
    Psychopharmacology, 1992, Volume: 106, Issue:1

    Topics: Animals; Brain Chemistry; Immunochemistry; Lithium; Male; Nerve Tissue Proteins; Paroxetine; Piperidines; Protein Binding; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta

1992
[3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment.
    Journal of neurochemistry, 1992, Volume: 58, Issue:1

    Topics: Animals; Brain; Fenclonine; Hydroxyindoleacetic Acid; Male; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tissue Distribution; Tritium

1992
Regional studies of serotonin and dopamine metabolism and quantification of serotonin uptake sites in human cerebral cortex.
    Journal of neural transmission. General section, 1992, Volume: 87, Issue:1

    Topics: Adolescent; Adult; Cerebral Cortex; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; In Vitro Techniques; Kinetics; Male; Membranes; Middle Aged; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sex Characteristics

1992
Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dopamine; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Norepinephrine; Paroxetine; Piperidines; Saimiri; Serotonin; Serotonin Antagonists

1992
Neurochemical changes in the rat brain after intraventricular administration of tryptamine-4,5-dione.
    Neuropharmacology, 1992, Volume: 31, Issue:3

    Topics: Animals; Brain Chemistry; Cerebral Cortex; Electrochemistry; Hydroxyindoleacetic Acid; In Vitro Techniques; Indolequinones; Injections, Intraventricular; Male; Membranes; Neurotransmitter Agents; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tryptamines; Tryptophan Hydroxylase

1992
Regional distribution to recovery of 5-HT levels after administration of "atrophins" MDMA and D,L-fenfluramine. Stereospecificity and comparison with 5,7-dihydroxytryptamine.
    Annals of the New York Academy of Sciences, 1992, May-11, Volume: 648

    Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; 5,7-Dihydroxytryptamine; Animals; Atrophy; Brain; Cerebral Ventricles; Designer Drugs; Dopamine; Fenfluramine; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Intraventricular; Male; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine; Organ Specificity; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism

1992
Age stability of human brain 5-HT terminals studied with [3H]paroxetine binding.
    Gerontology, 1992, Volume: 38, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Binding Sites; Biological Transport, Active; Brain; Child; Child, Preschool; Female; Humans; In Vitro Techniques; Infant; Infant, Newborn; Kinetics; Male; Middle Aged; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists; Sex Characteristics

1992
[123/125I]RTI-55, an in vivo label for the serotonin transporter.
    Synapse (New York, N.Y.), 1992, Volume: 11, Issue:2

    Topics: Animals; Biological Transport, Active; Cocaine; Fenfluramine; Histocytochemistry; Indicators and Reagents; Iodine Radioisotopes; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tomography, Emission-Computed, Single-Photon

1992
Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine.
    British journal of pharmacology, 1992, Volume: 105, Issue:4

    Topics: Animals; Biological Transport, Active; Blood Platelets; Clomipramine; Endothelium, Vascular; Fluoxetine; Lung; Male; Paroxetine; Piperidines; Plasma; Rats; Rats, Inbred Strains; Serotonin

1992
Presynaptic serotonin mechanisms in rats subjected to inescapable shock.
    Neuropharmacology, 1992, Volume: 31, Issue:4

    Topics: Analysis of Variance; Animals; Biological Transport; Brain; Electroshock; Escape Reaction; Helplessness, Learned; Hippocampus; Hypothalamus; In Vitro Techniques; Male; Models, Psychological; Paroxetine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stress, Psychological; Synapses

1992
The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes.
    British journal of clinical pharmacology, 1992, Volume: 33, Issue:5

    Topics: Antidepressive Agents; Carbon Radioisotopes; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Formates; Humans; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Paroxetine; Piperidines; Serotonin Antagonists

1992
Uptake and release of serotonin in rat cerebrovascular nerves after subarachnoid hemorrhage.
    Stroke, 1992, Volume: 23, Issue:1

    Topics: Animals; Basilar Artery; Electric Stimulation; Ischemic Attack, Transient; Ketanserin; Male; Oxidopamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Subarachnoid Hemorrhage; Sympathetic Nervous System; Tetrodotoxin; Vasoconstriction

1992
A clinical profile of paroxetine: a novel selective serotonin reuptake inhibitor (SSRI).
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Antidepressive Agents; Humans; Paroxetine; Piperidines; Serotonin Antagonists

1992
The relationship between paroxetine and the sparteine oxidation polymorphism.
    Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:3

    Topics: Adult; Humans; Oxidation-Reduction; Paroxetine; Phenotype; Piperidines; Polymorphism, Genetic; Serotonin Antagonists; Sparteine

1992
Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: nonlinearity and relation to the sparteine oxidation polymorphism.
    Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:3

    Topics: Adult; Aged; Diabetic Neuropathies; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Paroxetine; Phenotype; Piperidines; Polymorphism, Genetic; Serotonin Antagonists; Sparteine

1992
Novel selective serotonin reuptake inhibitors, Part I.
    The Journal of clinical psychiatry, 1992, Volume: 53, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Humans; Incidence; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Seizures; Serotonin; Suicide

1992
Serotonergic aspects of the response of human platelets to immune-adjuvant muramyl dipeptide.
    Journal of neuroimmunology, 1992, Volume: 37, Issue:1-2

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adenosine Diphosphate; Adjuvants, Immunologic; Blood Platelets; Carrier Proteins; Humans; Imipramine; Ketanserin; Lysergic Acid Diethylamide; Paroxetine; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Serotonin; Serotonin; Serotonin Antagonists

1992
Effects of the 5-HT uptake inhibitors, femoxetine and paroxetine, and a 5-HT1A/B agonist, eltoprazine, on the behavioural satiety sequence.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:4

    Topics: Animals; Behavior, Animal; Male; Paroxetine; Piperazines; Piperidines; Rats; Receptors, Serotonin; Satiety Response; Serotonin Antagonists

1992
One-step purification of the serotonin transporter located at the human platelet plasma membrane.
    The Journal of biological chemistry, 1992, Jun-05, Volume: 267, Issue:16

    Topics: Biological Transport; Blood Platelets; Blood Proteins; Carrier Proteins; Cell Membrane; Chromatography, Affinity; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Humans; Ouabain; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Tetrabenazine

1992
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
    Brain research, 1992, Feb-07, Volume: 571, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycemic Agents; Maternal-Fetal Exchange; Neurons; Pain; Paroxetine; Piperazines; Piperidines; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spinal Cord; Tetrahydronaphthalenes; Tropanes

1992
Prenatal cocaine exposure disrupts the development of the serotonergic system.
    Brain research, 1992, Feb-14, Volume: 572, Issue:1-2

    Topics: Animals; Animals, Newborn; Cocaine; Embryonic and Fetal Development; Female; Immunohistochemistry; Maternal-Fetal Exchange; Nerve Fibers; Neurons; Paroxetine; Piperidines; Pregnancy; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists

1992
Chloroamphetamine did not prevent the effects of chronic antidepressants on 5-hydroxytryptamine inhibition of forskolin-stimulated adenylate cyclase in rat hippocampus.
    European journal of pharmacology, 1991, Jul-12, Volume: 207, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Antidepressive Agents; Binding Sites; Cerebral Cortex; Chlorides; Colforsin; Hippocampus; Imipramine; Lithium; Lithium Chloride; Male; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Serotonin; Synapses; Tetrahydronaphthalenes

1991
Synthesis and 5-HT receptors binding studies of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines.
    Farmaco (Societa chimica italiana : 1989), 1991, Volume: 46, Issue:12

    Topics: Animals; Binding, Competitive; In Vitro Techniques; Ligands; Male; Paroxetine; Piperazines; Piperidines; Quinolones; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists

1991
Methylenedioxymethamphetamine induces spontaneous tail-flicks in the rat via 5-HT1A receptors.
    European journal of pharmacology, 1991, Feb-07, Volume: 193, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Reflex; Serotonin; Serotonin Antagonists; Tail

1991
Effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: autoradiographic and functional studies.
    Neuropharmacology, 1991, Volume: 30, Issue:6

    Topics: Adrenergic beta-Antagonists; Amitriptyline; Animals; Autoradiography; Brain Chemistry; Cyclic AMP; Desipramine; Iodine Radioisotopes; Iodocyanopindolol; Kinetics; Male; Membranes; Paroxetine; Pindolol; Piperidines; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin Antagonists

1991
Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4-methylenedioxymethamphetamine): assessment using quantitative autoradiography.
    Synapse (New York, N.Y.), 1991, Volume: 8, Issue:4

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Autoradiography; Brain; Dopamine; Male; Mazindol; N-Methyl-3,4-methylenedioxyamphetamine; Neural Pathways; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Time Factors

1991
Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ("Ecstasy").
    Psychopharmacology, 1991, Volume: 105, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Autoradiography; Brain Chemistry; Cerebral Cortex; Deoxyglucose; Glucose; Hippocampus; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists

1991
Reduction of in vivo binding of [3H]paroxetine in mouse brain by 3,4-methylenedioxymethamphetamine.
    Neuropharmacology, 1990, Volume: 29, Issue:7

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hydroxyindoleacetic Acid; Injections, Intravenous; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists

1990
Towards physiologically based treatment of patients with neuropathic pain.
    Pain, 1990, Volume: 42, Issue:2

    Topics: Analgesics; Animals; Clinical Trials as Topic; Humans; Nervous System Diseases; Pain; Pain Measurement; Palliative Care; Paroxetine; Piperidines

1990
Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats.
    Biochemical pharmacology, 1991, Jan-01, Volume: 41, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Blood Platelets; Frontal Lobe; Hydroxyindoleacetic Acid; Ketanserin; Kinetics; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Time Factors; Tritium

1991
Autoradiographic visualization of NK-3 tachykinin binding sites in the rat brain, utilizing [3H]senktide.
    Brain research, 1990, Nov-26, Volume: 534, Issue:1-2

    Topics: 5,7-Dihydroxytryptamine; Animals; Autoradiography; Brain; Kinetics; Male; Organ Specificity; Paroxetine; Peptide Fragments; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Reference Values; Serotonin Antagonists; Substance P; Tachykinins; Tritium

1990
[3H]paroxetine binding and serotonin content of rat and rabbit cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region.
    Synapse (New York, N.Y.), 1991, Volume: 9, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Binding Sites; Brain; Carrier Proteins; Cerebral Cortex; Corpus Striatum; Hippocampus; Hydroxyindoleacetic Acid; Kinetics; Male; Organ Specificity; Paroxetine; Piperidines; Rabbits; Radioligand Assay; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tegmentum Mesencephali; Tritium

1991
Radiosynthesis and evaluation of N-(3-[18F]fluoropropyl)paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by PET.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1991, Volume: 18, Issue:7

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Fluorine Radioisotopes; Magnetic Resonance Spectroscopy; Male; Mice; Paroxetine; Piperidines; Serotonin; Tomography, Emission-Computed

1991
[3H]citalopram binding to brain and platelet membranes of human and rat.
    Journal of neurochemistry, 1991, Volume: 56, Issue:1

    Topics: Animals; Binding Sites; Blood Platelets; Brain; Carrier Proteins; Cell Membrane; Citalopram; Humans; Imipramine; Kinetics; Neurons; Paroxetine; Piperidines; Rats; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Temperature; Thermodynamics

1991
Isothiocyanate derivatives of cocaine: irreversible inhibition of ligand binding at the dopamine transporter.
    Molecular pharmacology, 1991, Volume: 39, Issue:3

    Topics: Animals; Benzamides; Binding, Competitive; Brain Stem; Carrier Proteins; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Ligands; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Thiocyanates

1991
Modulation of [3H]paroxetine binding to the 5-hydroxytryptamine uptake site in an animal model of depression.
    Journal of neurochemistry, 1991, Volume: 56, Issue:5

    Topics: Animals; Binding Sites; Depression; Male; Paroxetine; Piperidines; Rats; Receptors, Serotonin; Reference Values; Serotonin Antagonists; Tritium

1991
Effects of acute paroxetine administration on tryptophan metabolism and disposition in the rat.
    British journal of pharmacology, 1991, Volume: 102, Issue:2

    Topics: Administration, Oral; Animals; Antidepressive Agents; Brain; Corticosterone; Enzyme Induction; Hydrocortisone; In Vitro Techniques; Liver; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase

1991
5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:1

    Topics: Amphetamines; Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Electrochemistry; Indans; Iodine Radioisotopes; Male; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains

1991
Ethanol intake and 3H-serotonin uptake. II: A study in alcoholic patients using platelets 3H-paroxetine binding.
    Life sciences, 1991, Volume: 48, Issue:20

    Topics: Adult; Alcoholism; Blood Platelets; Humans; Kinetics; Middle Aged; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists

1991
Characterization and purification of the neuronal sodium-ion-coupled 5-hydroxytryptamine transporter.
    Biochemical Society transactions, 1991, Volume: 19, Issue:1

    Topics: Animals; Binding, Competitive; Biological Transport, Active; Carrier Proteins; Cell Membrane; Cerebral Cortex; Kinetics; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Sodium

1991
3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Dopamine; In Vitro Techniques; Male; Molecular Structure; Nervous System; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Synaptosomes; Tritium

1991
Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding.
    British journal of pharmacology, 1991, Volume: 102, Issue:4

    Topics: Animals; Binding, Competitive; Cell Line; Cerebral Cortex; Imidazoles; Indoles; Kinetics; Ligands; Mice; Nervous System Neoplasms; Neuroblastoma; Paroxetine; Piperidines; Quipazine; Rats; Receptors, Serotonin; Serotonin Antagonists; Tumor Cells, Cultured

1991
Affinity modulation of [3H]imipramine, [3H]paroxetine and [3H]citalopram binding to the 5-HT transporter from brain and platelets.
    European journal of pharmacology, 1991, Mar-25, Volume: 206, Issue:3

    Topics: Animals; Blood Platelets; Brain; Carrier Proteins; Cell Membrane; Citalopram; Half-Life; Humans; Imipramine; In Vitro Techniques; Membrane Proteins; Paroxetine; Piperidines; Rats; Serotonin Plasma Membrane Transport Proteins

1991
No crossover reactions to citalopram or paroxetine among patients hypersensitive to zimeldine.
    The British journal of psychiatry : the journal of mental science, 1991, Volume: 158

    Topics: Aged; Aged, 80 and over; Antidepressive Agents; Citalopram; Combined Modality Therapy; Depressive Disorder; Drug Hypersensitivity; Female; Follow-Up Studies; Humans; Liver Function Tests; Male; Paroxetine; Piperidines; Serotonin Antagonists; Zimeldine

1991
Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats.
    European journal of pharmacology, 1991, Apr-10, Volume: 196, Issue:1

    Topics: Animals; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; Isoquinolines; Male; Monoamine Oxidase; Muscle Contraction; Muscle, Smooth, Vascular; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Stereoisomerism

1991
Evidence for high and low affinity [3H]cocaine binding sites associated with the serotonin reuptake complex in guinea pig brain: allosteric modulation by paroxetine.
    NIDA research monograph, 1990, Volume: 105

    Topics: Animals; Brain Chemistry; Carrier Proteins; Guinea Pigs; In Vitro Techniques; Kinetics; Membranes; Paroxetine; Piperidines; Receptors, Drug; Serotonin; Stereoisomerism

1990
Evidence for the existence of serotonin uptake inhibitor-like substances in human cerebrospinal fluid.
    Japanese journal of pharmacology, 1991, Volume: 56, Issue:3

    Topics: Animals; Binding Sites; Brain; Haplorhini; Humans; Imipramine; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists; Synaptosomes

1991
Sertraline (Lustral) and paroxetine (Seroxat)--new drugs for the treatment of depression.
    Drug and therapeutics bulletin, 1991, Jun-10, Volume: 29, Issue:12

    Topics: 1-Naphthylamine; Antidepressive Agents; Depressive Disorder; Humans; Paroxetine; Piperidines; Sertraline

1991
Concentration-response relationship in paroxetine treatment of diabetic neuropathy symptoms: a patient-blinded dose-escalation study.
    Therapeutic drug monitoring, 1991, Volume: 13, Issue:5

    Topics: Adult; Aged; Diabetic Neuropathies; Dosage Forms; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Pain Measurement; Paroxetine; Piperidines; Serotonin Antagonists

1991
Platelet 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat.
    Psychiatry research, 1991, Volume: 38, Issue:2

    Topics: 5,7-Dihydroxytryptamine; Animals; Brain; Depressive Disorder; Imipramine; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists

1991
3H-paroxetine binding in brains of alcoholics.
    Psychiatry research, 1991, Volume: 38, Issue:3

    Topics: Adult; Aged; Alcoholism; Binding Sites; Cerebral Cortex; Data Interpretation, Statistical; Female; Hippocampus; Humans; Male; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists

1991
Platelet 3H-imipramine and 3H-paroxetine binding during treatment with psychoactive drugs.
    Biological psychiatry, 1991, Nov-15, Volume: 30, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Female; Humans; Imipramine; Male; Mental Disorders; Middle Aged; Paroxetine; Piperidines; Psychotropic Drugs; Radioligand Assay; Serotonin Antagonists

1991
Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1991, Volume: 5, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Electric Stimulation; Electrophysiology; Hippocampus; Imipramine; Male; Neurons; Paroxetine; Piperidines; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Synapses; Tetrahydronaphthalenes

1991
Pharmacokinetics of paroxetine in patients with cirrhosis.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:4

    Topics: Adult; Aged; Cimetidine; Disulfiram; Drug Interactions; Female; Half-Life; Humans; Liver Cirrhosis, Alcoholic; Liver Function Tests; Male; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists

1991
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Behavior, Animal; Catecholamines; Cerebral Cortex; Hippocampus; Indans; Lysergic Acid Diethylamide; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Psychotropic Drugs; Rats; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes

1990
5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents.
    European journal of pharmacology, 1990, Feb-20, Volume: 177, Issue:1-2

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain Chemistry; In Vitro Techniques; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Synaptosomes

1990
Neurochemistry and neurotoxicity of substituted amphetamines.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1990, Volume: 3, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Designer Drugs; Fenfluramine; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Paroxetine; Piperidines; Rats; Receptors, Serotonin; Serotonin

1990
Laminar distributions of muscarinic acetylcholine, serotonin, GABA and opioid receptors in human posterior cingulate cortex.
    Neuroscience, 1990, Volume: 36, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Autoradiography; Cerebral Cortex; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Humans; Iodocyanopindolol; Ketanserin; Male; Middle Aged; Oxotremorine; Paroxetine; Pindolol; Piperidines; Pirenzepine; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Opioid; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes

1990
Effect of prolonged 5-hydroxytryptamine uptake inhibition by paroxetine on cortical beta 1 and beta 2-adrenoceptors in rat brain.
    Life sciences, 1990, Volume: 47, Issue:18

    Topics: Adrenergic beta-Antagonists; Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Dose-Response Relationship, Drug; Imidazoles; Kinetics; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Propanolamines; Radioligand Assay; Rats; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin

1990
Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomography ligand?
    Brain research, 1990, Sep-10, Volume: 527, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; 5,7-Dihydroxytryptamine; Animals; Ligands; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Synapses; Tomography, Emission-Computed; Tritium

1990
Antidepressant binding sites in brain: autoradiographic comparison of [3H]paroxetine and [3H]imipramine localization and relationship to serotonin transporter.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: Animals; Antidepressive Agents; Autoradiography; Binding Sites; Brain; Imipramine; In Vitro Techniques; Kinetics; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin

1990
Regional distribution of the serotonin transport complex in human brain, identified with 3H-paroxetine, 3H-citalopram and 3H-imipramine.
    Progress in neuro-psychopharmacology & biological psychiatry, 1990, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Aged; Binding, Competitive; Biological Transport; Brain; Citalopram; Female; Humans; Imipramine; Kinetics; Male; Membranes; Middle Aged; Organ Specificity; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists

1990
Serotonergic and catecholaminergic reuptake inhibitors have opposite effects on the ultrasonic isolation calls of rat pups.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1990, Volume: 3, Issue:1

    Topics: Animals; Body Temperature; Catecholamines; Citalopram; Clomipramine; Desipramine; Flumazenil; Mazindol; Motor Activity; Naltrexone; Nortriptyline; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Stress, Psychological; Ultrasonics; Vocalization, Animal

1990
Cellular localization of serotonin 1A, 1B and uptake sites in cingulate cortex of the rat.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Immunotoxins; Iodocyanopindolol; Male; Paroxetine; Pindolol; Piperidines; Rats; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes

1990
[3H] sertraline binding to rat brain membranes.
    Psychopharmacology, 1990, Volume: 100, Issue:4

    Topics: 1-Naphthylamine; Animals; Brain; Fenclonine; Fluoxetine; Imipramine; In Vitro Techniques; Male; Membranes; Naphthalenes; Paroxetine; Piperidines; Rats; Receptors, Serotonin; Serotonin Antagonists; Sertraline

1990
Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:1

    Topics: Animals; Biogenic Monoamines; Fenfluramine; Frontal Lobe; Hippocampus; Male; Neurons; Norfenfluramine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism

1990
Effect of serotonergic lesion on "anxious" behaviour measured in the elevated plus-maze test in the rat.
    Psychopharmacology, 1990, Volume: 101, Issue:2

    Topics: 5,7-Dihydroxytryptamine; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Injections, Intraventricular; Kinetics; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin

1990
High-affinity paroxetine binding to the human placental serotonin transporter.
    The American journal of physiology, 1990, Volume: 259, Issue:2 Pt 1

    Topics: 4-Chloro-7-nitrobenzofurazan; Binding, Competitive; Biological Transport; Carrier Proteins; Female; Humans; Imidazoles; Kinetics; Microvilli; Paroxetine; Piperidines; Placenta; Pregnancy; Serotonin; Serotonin Antagonists; Sodium; Tetranitromethane; Tyrosine

1990
Inhibition of neuronal 5-HT uptake by ketamine, but not halothane, involves disruption of substrate recognition by the transporter.
    Neuroscience letters, 1990, Apr-20, Volume: 112, Issue:1

    Topics: Anesthetics; Animals; Brain; Halothane; Ketamine; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Synaptosomes

1990
Effects of high-dose fenfluramine treatment on monoamine uptake sites in rat brain: assessment using quantitative autoradiography.
    Synapse (New York, N.Y.), 1990, Volume: 6, Issue:1

    Topics: Animals; Autoradiography; Biogenic Monoamines; Brain; Fenfluramine; Male; Mazindol; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Tritium

1990
Seasonal variations in binding of 3H-paroxetine to blood platelets in healthy volunteers: indications for a gender difference.
    Biological psychiatry, 1990, Sep-15, Volume: 28, Issue:6

    Topics: Adult; Blood Platelets; Carrier Proteins; Female; Humans; Longitudinal Studies; Male; Paroxetine; Piperidines; Reference Values; Seasons; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Sex Factors

1990
Symmetrical hemispheric distribution of 3H-paroxetine binding sites in postmortem human brain from controls and suicides.
    Biological psychiatry, 1990, Sep-15, Volume: 28, Issue:6

    Topics: Adult; Brain; Brain Mapping; Depressive Disorder; Dominance, Cerebral; Female; Frontal Lobe; Humans; Male; Middle Aged; Paroxetine; Piperidines; Putamen; Receptors, Serotonin; Retrospective Studies; Serotonin Antagonists; Substantia Nigra; Suicide

1990
Evaluation of 3H-paroxetine as a radioligand for in vivo study of 5-hydroxytryptamine uptake sites in mouse brain.
    Radioisotopes, 1990, Volume: 39, Issue:8

    Topics: Animals; Binding Sites; Brain; Evaluation Studies as Topic; Injections, Intravenous; Male; Mice; Paroxetine; Piperidines; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Tritium

1990
Interaction of fluoxetine with the human placental serotonin transporter.
    Biochemical pharmacology, 1990, Nov-01, Volume: 40, Issue:9

    Topics: Carrier Proteins; Female; Fluoxetine; Humans; In Vitro Techniques; Microvilli; Paroxetine; Piperidines; Placenta; Pregnancy; Serotonin; Serotonin Antagonists

1990
Preparation and characterization of anti-paroxetine antibodies.
    Life sciences, 1990, Volume: 47, Issue:14

    Topics: Animals; Antibody Affinity; Antibody Specificity; Cross Reactions; Glutaral; Haptens; Immunoglobulin G; Paroxetine; Piperidines; Rabbits; Radioimmunoassay; Serotonin Antagonists; Serum Albumin, Bovine

1990
Inhibitory and regulatory binding sites on the rat brain serotonin transporter: molecular weight of the [3H]paroxetine and [3H]citalopram binding proteins.
    European journal of pharmacology, 1990, Sep-18, Volume: 189, Issue:2-3

    Topics: Animals; Biological Transport, Active; Brain; Carrier Proteins; Citalopram; Half-Life; In Vitro Techniques; Kinetics; Models, Biological; Molecular Weight; Paroxetine; Piperidines; Rats; Receptors, Serotonin

1990
Binding of [3H]dihydrotetrabenazine and [125I]azidoiodoketanserin photoaffinity labeling of the monoamine transporter of platelet 5-HT organelles.
    European journal of pharmacology, 1990, Sep-04, Volume: 186, Issue:1

    Topics: Affinity Labels; Animals; Azides; Biogenic Monoamines; Blood Platelets; Blood Proteins; Cell Membrane; Guinea Pigs; Humans; In Vitro Techniques; Iodine Radioisotopes; Ketanserin; Paroxetine; Photochemistry; Piperidines; Rabbits; Rats; Receptors, Serotonin; Subcellular Fractions; Tetrabenazine

1990
Prenatal treatment with a selective D1 receptor agonist (SKF 38393) alters adult [3H]paroxetine binding and dopamine and serotonin behavioral sensitivity.
    Brain research. Developmental brain research, 1990, Dec-15, Volume: 57, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Brain Stem; Cerebral Cortex; Conditioning, Operant; Dopamine; Female; Kinetics; Paroxetine; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Serotonin

1990
Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides.
    Brain research, 1990, Aug-27, Volume: 526, Issue:1

    Topics: Brain Chemistry; Depressive Disorder; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Receptors, Serotonin; Retrospective Studies; Serotonin Antagonists; Suicide; Tritium

1990
Inhibition of MAO activity, 3H-imipramine binding, 3H-paroxetine binding and 3H-5-HT uptake by human cerebrospinal fluid.
    Journal of neural transmission. Supplementum, 1990, Volume: 32

    Topics: Animals; Binding, Competitive; Brain; Cerebral Cortex; Cerebrospinal Fluid; Humans; Imipramine; Kinetics; Macaca mulatta; Membranes; Mitochondria; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Receptors, Drug; Serotonin

1990
Interaction between serotonin uptake inhibitors and alpha-2 adrenergic heteroreceptors in the rat hypothalamus.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1

    Topics: Animals; Brimonidine Tartrate; Citalopram; Fenclonine; Hypothalamus; In Vitro Techniques; Male; Norepinephrine; Paroxetine; Piperidines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Serotonin Antagonists

1990
Why some depressed patients may have low platelet 3H-imipramine binding.
    Acta psychiatrica Scandinavica, 1990, Volume: 82, Issue:4

    Topics: Antidepressive Agents; Blood Platelets; Carrier Proteins; Cell Membrane; Clomipramine; Depressive Disorder; Humans; Imipramine; Paroxetine; Piperidines; Receptors, Drug; Receptors, Neurotransmitter; Serotonin Antagonists

1990
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Brain Chemistry; Dopamine; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tritium

1987
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
    Pharmacology & toxicology, 1988, Volume: 63, Issue:3

    Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imipramine; Ketanserin; Kinetics; Male; Paroxetine; Piperidines; Prazosin; Proteins; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Time Factors

1988
Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Monoamines; Brain Chemistry; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin

1989
Postsynaptic localization and up-regulation of serotonin 5-HT1D receptors in rat brain.
    Brain research, 1989, Mar-27, Volume: 483, Issue:1

    Topics: Animals; Cerebral Cortex; Corpus Striatum; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin

1989
In vivo labeling of serotonin uptake sites with [3H]paroxetine.
    Journal of neurochemistry, 1989, Volume: 52, Issue:5

    Topics: Affinity Labels; Animals; Brain; Cerebellum; Hypothalamus; Kinetics; Male; Mice; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stereoisomerism; Tissue Distribution; Tritium; Zimeldine

1989
High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue.
    Brain research, 1989, May-08, Volume: 486, Issue:2

    Topics: Aged; Aged, 80 and over; Binding, Competitive; Brain; Citalopram; Female; Humans; Kinetics; Male; Middle Aged; Paroxetine; Piperidines; Receptors, Serotonin

1989
Nialamide-induced hypermotility in mice treated with inhibitors of monoamine uptake, 5-HT antagonists and lithium.
    Psychopharmacology, 1989, Volume: 98, Issue:2

    Topics: Animals; Diet; Female; Lithium; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Nialamide; Paroxetine; Piperidines; Serotonin Antagonists

1989
Production of wet-dog shakes in rats and down-regulation of spinal 5-HT2 receptors.
    European journal of pharmacology, 1989, May-30, Volume: 164, Issue:3

    Topics: Animals; Behavior, Animal; Brain Stem; Ketanserin; Male; Paroxetine; Phenelzine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Spinal Cord

1989
Differences in the temperature dependence of drug interaction with the noradrenaline and serotonin transporters.
    Neuropharmacology, 1989, Volume: 28, Issue:8

    Topics: Animals; Biogenic Monoamines; Blood Platelets; Humans; Imipramine; In Vitro Techniques; Male; Mazindol; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Salivary Glands; Serotonin; Serotonin Antagonists; Temperature

1989
Drug inhibition indicates a single-site model of the 5-HT uptake site/antidepressant binding site in rat and human brain.
    Psychopharmacology, 1989, Volume: 99, Issue:1

    Topics: Aged; Animals; Antidepressive Agents; Binding Sites; Brain; Citalopram; Clomipramine; Humans; In Vitro Techniques; Male; Middle Aged; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin

1989
Light-dark differences in [3H]-paroxetine binding to rabbit platelet membranes.
    Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 340, Issue:1

    Topics: Animals; Blood Platelets; Cell Membrane; Circadian Rhythm; Darkness; Imipramine; In Vitro Techniques; Light; Male; Paroxetine; Piperidines; Rabbits; Serotonin Antagonists

1989
Synthesis and 5HT-receptors affinity of some 4-phenylquinoline derivatives.
    Farmaco (Societa chimica italiana : 1989), 1989, Volume: 44, Issue:6

    Topics: Animals; Brain; Chemical Phenomena; Chemistry; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Paroxetine; Piperidines; Quinolines; Quipazine; Rats; Receptors, Serotonin; Serotonin Antagonists; Synapses

1989
[Behavioral pharmacological properties of the novel antidepressant paroxetine, a selective 5-HT uptake inhibitor].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1989, Volume: 94, Issue:3

    Topics: Aggression; Anesthesia; Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Male; Mice; Motor Activity; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Stereotyped Behavior

1989
[Evaluation of 3H-paroxetine as a radiopharmaceutical for lung function].
    Kaku igaku. The Japanese journal of nuclear medicine, 1989, Volume: 26, Issue:7

    Topics: Animals; Lung; Male; Mice; Paroxetine; Piperidines; Radionuclide Imaging; Serotonin Antagonists; Tissue Distribution; Tritium

1989
The antidepressant paroxetine: a specific 5-HT uptake inhibitor. Proceedings of an international symposium. September, 1988.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Humans; Paroxetine; Piperidines

1989
Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Diazepam; Digoxin; Drug Interactions; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists; Warfarin

1989
Introduction to the development of paroxetine, a novel antidepressant.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Depressive Disorder; Humans; Paroxetine; Piperidines; Serotonin Antagonists

1989
Antidepressants and the peripheral nervous system.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Amitriptyline; Antidepressive Agents; Depressive Disorder; Electromyography; Humans; Neural Conduction; Paroxetine; Peripheral Nerves; Piperidines; Serotonin Antagonists

1989
Paroxetine plasma levels: lack of correlation with efficacy or adverse events.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Depressive Disorder; Humans; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Retrospective Studies; Serotonin Antagonists

1989
Ability of charcoal to prevent absorption of paroxetine.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Administration, Oral; Adult; Antidepressive Agents; Charcoal; Dose-Response Relationship, Drug; Humans; Intestinal Absorption; Male; Paroxetine; Piperidines; Serotonin Antagonists

1989
Pharmacological effects of paroxetine after repeated administration to animals.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Cerebral Cortex; Male; Paroxetine; Piperidines; Radioligand Assay; Rats; Receptors, Serotonin; Serotonin Antagonists

1989
Metabolic pathway of paroxetine in animals and man and the comparative pharmacological properties of its metabolites.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Animals; Antidepressive Agents; Biotransformation; Brain; Chemical Phenomena; Chemistry; Humans; Hypothalamus; Mice; Paroxetine; Piperidines; Rats; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Synaptosomes

1989
Relative lack of cardiotoxicity of paroxetine in animal models.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Amitriptyline; Animals; Antidepressive Agents; Blood Pressure; Cats; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart Conduction System; Heart Rate; Paroxetine; Piperidines; Serotonin Antagonists

1989
Comparative acute toxicity of paroxetine and other antidepressants.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Animals; Antidepressive Agents; Arousal; Dogs; Dose-Response Relationship, Drug; Lethal Dose 50; Macaca mulatta; Mice; Paroxetine; Piperidines; Rats; Serotonin Antagonists

1989
General and genetic toxicology of paroxetine.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Animals; Antidepressive Agents; Carcinogenicity Tests; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Mice; Mutagenicity Tests; Paroxetine; Piperidines; Rats; Serotonin Antagonists

1989
The reproductive toxicology of paroxetine.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Abnormalities, Drug-Induced; Animals; Antidepressive Agents; Body Weight; Dose-Response Relationship, Drug; Female; Litter Size; Paroxetine; Piperidines; Pregnancy; Pregnancy, Animal; Rabbits; Rats; Serotonin Antagonists

1989
Immunological evaluation of paroxetine.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Animals; Antibodies; Antidepressive Agents; Humans; Immunity, Cellular; Paroxetine; Piperidines; Serotonin Antagonists

1989
Regional distribution of serotonergic pre- and postsynaptic markers in human brain.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Antidepressive Agents; Brain; Brain Mapping; Dose-Response Relationship, Drug; Humans; Paroxetine; Piperidines; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Synapses

1989
The pharmacokinetics of paroxetine in the elderly.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Administration, Oral; Adult; Age Factors; Aged; Antidepressive Agents; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Reference Values; Serotonin Antagonists

1989
The pharmacokinetics of paroxetine in patients with liver cirrhosis.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Aged; Antidepressive Agents; Female; Humans; Intestinal Absorption; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists

1989
Paroxetine: lack of effect on hepatic drug metabolizing enzymes.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Animals; Antidepressive Agents; Antipyrine; Cytochrome P-450 Enzyme System; Enzymes; Humans; Inactivation, Metabolic; Microsomes, Liver; Paroxetine; Piperidines; Rats; Serotonin Antagonists

1989
A common binding site for tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors at the substrate recognition site of the neuronal sodium-dependent 5-hydroxytryptamine transporter.
    Biochemical pharmacology, 1989, Nov-01, Volume: 38, Issue:21

    Topics: Animals; Antidepressive Agents, Tricyclic; Binding Sites; Binding, Competitive; Biological Transport; Cerebral Cortex; Citalopram; Dose-Response Relationship, Drug; Ethylmaleimide; Fluoxetine; Imipramine; Male; Neurons; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sodium

1989
Brain 5-HT uptake sites, labelled with [3H]-paroxetine, in post-mortem samples from depressed suicide victims.
    British journal of pharmacology, 1989, Volume: 98 Suppl

    Topics: Adult; Brain; Depressive Disorder; Female; Humans; In Vitro Techniques; Male; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin Antagonists; Suicide

1989
'[3H]quipazine' degradation products label 5-HT uptake sites.
    European journal of pharmacology, 1989, Nov-14, Volume: 171, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; In Vitro Techniques; Paroxetine; Piperidines; Quinolines; Quipazine; Radioligand Assay; Rats; Receptors, Serotonin

1989
Inhibition and dissociation of [3H]-paroxetine binding to human platelets.
    Neuropsychobiology, 1989, Volume: 22, Issue:3

    Topics: Antidepressive Agents; Binding, Competitive; Blood Platelets; Dose-Response Relationship, Drug; Humans; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists

1989
Effect of 5-hydroxytryptamine on [3H]-acetylcholine release from guinea-pig striatal slices.
    British journal of pharmacology, 1989, Volume: 97, Issue:1

    Topics: Acetylcholine; Animals; Caudate Nucleus; Corpus Striatum; Dopamine; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Neurotransmitter Agents; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists

1989
Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat.
    Neuroscience letters, 1989, Sep-25, Volume: 104, Issue:1-2

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Cerebral Cortex; Corpus Striatum; Designer Drugs; Dopamine; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Nervous System Diseases; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Reserpine; Serotonin

1989
Repeated electroconvulsive shock does not change [3H]-paroxetine binding to the 5-HT uptake site in rat cortical membranes.
    Psychopharmacology, 1988, Volume: 95, Issue:1

    Topics: Animals; Cerebral Cortex; Electroshock; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin Antagonists; Tritium

1988
Interaction between tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors and the presynaptic 5-hydroxytryptamine inhibitory autoreceptors in the rat hypothalamus.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:1

    Topics: 5-Methoxytryptamine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Citalopram; Electric Stimulation; Fenclonine; Hypothalamus; Imipramine; Lysergic Acid Diethylamide; Male; Methiothepin; Neurotransmitter Agents; Pargyline; Paroxetine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin

1985
Reduced high-affinity glutamate uptake sites in the brains of patients with Huntington's disease.
    Neuroscience letters, 1986, Jun-18, Volume: 67, Issue:2

    Topics: Aged; Aspartic Acid; Brain; Caudate Nucleus; Female; Frontal Lobe; Glutamates; Glutamic Acid; Hippocampus; Humans; Huntington Disease; Male; Middle Aged; Paroxetine; Piperidines; Putamen

1986
The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants.
    The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:11

    Topics: Animals; Blood Platelets; Humans; Imipramine; In Vitro Techniques; Neurons; Paroxetine; Piperidines; Rats; Serotonin; Structure-Activity Relationship; Synaptosomes

1987
Paroxetine, a selective 5-hydroxytryptamine uptake inhibitor with antidepressant properties, lacks amphetamine-like stimulus properties in an operant drug discrimination bioassay in rodents.
    The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:3

    Topics: Animals; Antidepressive Agents; Conditioning, Operant; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Female; Flicker Fusion; Nomifensine; Paroxetine; Piperidines; Psychomotor Performance; Rats; Serotonin Antagonists; Tranylcypromine

1988
Characterization of [3H]paroxetine binding to rat cortical membranes.
    European journal of pharmacology, 1985, Nov-26, Volume: 118, Issue:1-2

    Topics: Animals; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; Membranes; Nerve Endings; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin

1985
Effects of antidepressant drug combinations on cortical 5-HT2 receptors and wet-dog shakes in rats.
    European journal of pharmacology, 1985, Dec-03, Volume: 118, Issue:3

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Carbidopa; Cerebral Cortex; Citalopram; Drug Interactions; Fenfluramine; Male; Methoxydimethyltryptamines; Paroxetine; Phenelzine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reflex; Serotonin; Time Factors

1985
Antidepressive drugs can change the affinity of [3H]imipramine and [3H]paroxetine binding to platelet and neuronal membranes.
    European journal of pharmacology, 1985, Dec-10, Volume: 119, Issue:1-2

    Topics: Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Blood Platelets; Brain; Cell Membrane; Citalopram; Imipramine; In Vitro Techniques; Kinetics; Paroxetine; Piperidines; Propylamines; Rats; Serotonin; Serotonin Antagonists; Synaptic Membranes

1985
Parkinson's disease: decreased density of 3H-imipramine and 3H-paroxetine binding sites in putamen.
    Neurology, 1986, Volume: 36, Issue:4

    Topics: Aged; Binding Sites; Humans; Imipramine; Middle Aged; Parkinson Disease; Paroxetine; Piperidines; Putamen; Tritium

1986
The stereoselectivity of serotonin uptake in brain tissue and blood platelets: the topography of the serotonin uptake area.
    Neuroscience and biobehavioral reviews, 1986,Spring, Volume: 10, Issue:1

    Topics: Alanine; Amphetamine; Aniline Compounds; Animals; Antidepressive Agents; Blood Platelets; Brain; Fluoxetine; Humans; Male; Methadone; Mianserin; Mirtazapine; Morpholines; Naphthalenes; Nefopam; Nomifensine; Paroxetine; Piperidines; Rabbits; Serotonin; Stereoisomerism; Tranylcypromine; Viloxazine; Zimeldine

1986
Comparison of some effects of paroxetine with amitriptyline on the cardiovascular system in animals.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents; Cats; Drug Evaluation, Preclinical; Electrocardiography; Female; Heart Conduction System; Hypotension; Infusions, Parenteral; Male; Myocardial Contraction; Paroxetine; Piperidines; Rabbits; Seizures; Serotonin Antagonists; Tachycardia

1986
Solubilization and characterization of the 5-hydroxytryptamine transporter complex from rat cerebral cortical membranes.
    European journal of pharmacology, 1986, Mar-18, Volume: 122, Issue:2

    Topics: Animals; Biological Transport; Cerebral Cortex; Chromatography, Gel; Kinetics; Male; Membranes; Paroxetine; Piperidines; Rats; Serotonin

1986
High affinity binding of 3H-paroxetine and 3H-imipramine to rat neuronal membranes.
    Psychopharmacology, 1986, Volume: 89, Issue:4

    Topics: Animals; Binding Sites; Blood Platelets; Brain; Female; Imipramine; In Vitro Techniques; Membranes; Paroxetine; Piperidines; Rats; Rats, Inbred Strains

1986
High- and low-affinity binding of [3H]imipramine in rat hypothalamus.
    Journal of neurochemistry, 1986, Volume: 47, Issue:5

    Topics: Amitriptyline; Animals; Citalopram; Clomipramine; Cyclopropanes; Hypothalamus; Imipramine; Kinetics; Male; Milnacipran; Paroxetine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Serotonin; Sodium

1986
Temperature dependence of drug interaction with the platelet 5-hydroxytryptamine transporter: a clue to the imipramine selectivity paradox.
    Journal of neurochemistry, 1987, Volume: 48, Issue:2

    Topics: Biological Transport, Active; Blood Platelets; Humans; Imipramine; Kinetics; Paroxetine; Piperidines; Receptors, Serotonin; Temperature

1987
Chlorimipramine--but not imipramine--rapidly reduces imipramine--but not paroxetine--binding in human platelets.
    Clinical neuropharmacology, 1986, Volume: 9 Suppl 4

    Topics: Blood Platelets; Clomipramine; Humans; Imipramine; Iodine; Paroxetine; Piperidines; Serotonin; Tritium

1986
Effect of chronic treatment with selective monoamine oxidase inhibitors and specific 5-hydroxytryptamine uptake inhibitors on [3H]paroxetine binding to cerebral cortical membranes of the rat.
    Neuropharmacology, 1987, Volume: 26, Issue:8

    Topics: Animals; Cerebral Cortex; Citalopram; Clomipramine; Clorgyline; Kinetics; Male; Membranes; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Selegiline; Serotonin

1987
Determination of paroxetine in human plasma, using high-performance liquid chromatography with fluorescence detection.
    Journal of chromatography, 1987, Aug-07, Volume: 419

    Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Humans; Indicators and Reagents; Paroxetine; Piperidines; Serotonin Antagonists; Spectrometry, Fluorescence

1987
Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor.
    Psychopharmacology, 1987, Volume: 93, Issue:2

    Topics: Animals; Antidepressive Agents; Biological Transport, Active; Brain; In Vitro Techniques; Kinetics; Male; Norepinephrine; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Serotonin; Serotonin Antagonists; Synaptosomes

1987
In vivo voltammetric study of cortical 5-HT after administration of 5-HTP or paroxetine to phenelzine-treated rats.
    The Journal of Nihon University School of Dentistry, 1987, Volume: 29, Issue:3

    Topics: 5-Hydroxytryptophan; Animals; Cerebral Cortex; Male; Microelectrodes; Paroxetine; Phenelzine; Piperidines; Rats; Rats, Inbred Strains; Serotonin

1987
Cardiovascular effects of paroxetine, a newly developed antidepressant, in anesthetized dogs in comparison with those of imipramine, amitriptyline and clomipramine.
    Japanese journal of pharmacology, 1987, Volume: 45, Issue:3

    Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents; Atrioventricular Node; Blood Pressure; Clomipramine; Dogs; Electrocardiography; Female; Heart Conduction System; Heart Rate; Hemodynamics; Imipramine; Male; Paroxetine; Piperidines; Respiration

1987
Effects of the selective 5-hydroxytryptamine uptake inhibitors paroxetine and zimeldine on EEG sleep and waking stages in the rat.
    Neuropsychobiology, 1987, Volume: 17, Issue:4

    Topics: Administration, Oral; Animals; Brain; Electroencephalography; Female; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Sleep; Sleep Stages; Wakefulness; Zimeldine

1987
Characterization of [3H]paroxetine binding in rat brain.
    Journal of neurochemistry, 1988, Volume: 50, Issue:6

    Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cerebral Cortex; Citalopram; Fluoxetine; Imipramine; Male; Paroxetine; Peptide Hydrolases; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tritium

1988
Electroencephalographic effects of the new antidepressant paroxetine in the rabbit.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents; Arousal; Drug Interactions; Electric Stimulation; Electroencephalography; Limbic System; Male; Paroxetine; Photic Stimulation; Physostigmine; Piperidines; Rabbits; Recruitment, Neurophysiological

1988
Regional and subcellular localization in human brain of [3H]paroxetine binding, a marker of serotonin uptake sites.
    Biological psychiatry, 1988, Volume: 24, Issue:3

    Topics: Adult; Aged; Animals; Binding, Competitive; Brain; Brain Mapping; Cerebral Cortex; Corpus Striatum; Humans; Ketanserin; Male; Middle Aged; Paroxetine; Piperidines; Putamen; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Subcellular Fractions; Synaptosomes

1988
Immunological studies on paroxetine, a novel anti-depressant drug.
    International journal of immunopharmacology, 1988, Volume: 10, Issue:4

    Topics: Adult; Aged; Animals; Antibody Formation; Antidepressive Agents; Female; Guinea Pigs; Humans; Immunity; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Middle Aged; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists

1988
Dissociation kinetics of [3H]paroxetine binding to rat brain consistent with a single-site model of the antidepressant binding/5-hydroxytryptamine uptake site.
    Journal of neurochemistry, 1988, Volume: 51, Issue:5

    Topics: Animals; Brain; Cell Membrane; Citalopram; Clomipramine; Imipramine; Kinetics; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Zimeldine

1988
Changes in cortical 5-HT2 receptors following 5-HTP and paroxetine administration in rats.
    The Journal of Nihon University School of Dentistry, 1988, Volume: 30, Issue:3

    Topics: Animals; Carbidopa; Cerebral Cortex; Ketanserin; Male; Paroxetine; Phenelzine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin

1988
Autoradiographic localization of 3H-paroxetine-labeled serotonin uptake sites in rat brain.
    Synapse (New York, N.Y.), 1987, Volume: 1, Issue:5

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cerebral Cortex; Kinetics; Male; Organ Specificity; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Synaptosomes; Tritium

1987
Autoradiography of antidepressant binding sites in the human brain: localization using [3H]imipramine and [3H]paroxetine.
    Neuroscience, 1988, Volume: 27, Issue:2

    Topics: Aged; Aged, 80 and over; Antidepressive Agents; Autoradiography; Brain; Child; Female; Humans; Imipramine; Male; Middle Aged; Paroxetine; Piperidines; Receptors, Serotonin; Spinal Cord

1988
[Characteristics of 3H-paroxetine-labeled serotonin uptake sites in rat brain].
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1988, Volume: 8, Issue:2

    Topics: Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Brain; In Vitro Techniques; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Tritium

1988
Measuring the serotonin uptake site using [3H]paroxetine--a new serotonin uptake inhibitor.
    Advances in alcohol & substance abuse, 1988, Volume: 7, Issue:3-4

    Topics: Animals; Cerebral Cortex; Electroconvulsive Therapy; Imipramine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Obese; Paroxetine; Piperidines; Receptors, Serotonin; Tritium

1988
Platelet 3H-paroxetine binding in depressed patients.
    Psychiatry research, 1988, Volume: 26, Issue:1

    Topics: Adult; Antidepressive Agents; Blood Platelets; Depressive Disorder; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychological Tests; Serotonin

1988
First results of an open phase II study with the antidepressant paroxetine.
    Pharmacopsychiatry, 1988, Volume: 21, Issue:6

    Topics: Adult; Aged; Antidepressive Agents; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales

1988
Specific binding sites for cyclic antidepressants.
    Acta pharmacologica et toxicologica, 1985, Volume: 56 Suppl 1

    Topics: Animals; Binding Sites; Carrier Proteins; Humans; Imipramine; Paroxetine; Piperidines; Receptors, Drug; Receptors, Neurotransmitter; Serotonin; Temperature

1985
p,p'-DDT-induced myoclonus in mice: the effect of enhanced 5-HT neurotransmission.
    Acta pharmacologica et toxicologica, 1985, Volume: 56, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Carbidopa; DDT; Female; Mice; Mice, Inbred Strains; Myoclonus; Paroxetine; Piperidines; Serotonin; Synaptic Transmission; Tryptophan

1985
Pitfalls in demonstrating an endogenous ligand of imipramine recognition sites.
    Biochemical pharmacology, 1987, Mar-15, Volume: 36, Issue:6

    Topics: Animals; Binding Sites; Brain Chemistry; Chromatography, High Pressure Liquid; Imipramine; Ligands; Osmolar Concentration; Paroxetine; Piperidines; Rats; Receptors, Cell Surface; Serotonin; Serotonin Antagonists

1987
[Specific inhibitory action of a novel antidepressant paroxetine on 5-HT uptake].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1987, Volume: 89, Issue:4

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain; Dopamine; Guinea Pigs; In Vitro Techniques; Male; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin

1987
Association of [3H]-imipramine and [3H]-paroxetine binding with the 5HT transporter in brain and platelets: relevance to studies in depression.
    Journal of receptor research, 1987, Volume: 7, Issue:1-4

    Topics: Animals; Antidepressive Agents; Blood Platelets; Brain Chemistry; Carrier Proteins; Depressive Disorder; Female; Humans; Imipramine; Male; Paroxetine; Piperidines; Rabbits; Rats; Receptors, Drug; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin

1987
A comparison of the effect of paroxetine and amitriptyline on the tyramine pressor response test.
    British journal of clinical pharmacology, 1985, Volume: 19, Issue:5

    Topics: Adult; Amitriptyline; Blood Pressure; Humans; Hypnotics and Sedatives; Male; Paroxetine; Piperidines; Serotonin Antagonists; Tyramine

1985
Is waning of a 5-hydroxytryptamine (5-HT)-mediated syndrome due to 5-HT2 receptor down-regulation?
    Neuroscience letters, 1985, Apr-19, Volume: 55, Issue:3

    Topics: Animals; Cerebral Cortex; Ketanserin; Male; Myoclonus; Paroxetine; Phenelzine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Syndrome; Time Factors; Tritium

1985
Size determination of binding polymers for [3H]imipramine and [3H]paroxetine in human platelet membranes.
    European journal of pharmacology, 1984, Nov-13, Volume: 106, Issue:2

    Topics: Blood Platelets; Carrier Proteins; Cell Membrane; Electrons; Humans; Imipramine; In Vitro Techniques; Membrane Proteins; Molecular Weight; Paroxetine; Piperidines; Protein Binding; Receptors, Drug; Receptors, Neurotransmitter; Serotonin Antagonists

1984
Treatment of myoclonic syndromes with paroxetine alone or combined with 5-HTP.
    Acta neurologica Scandinavica, 1982, Volume: 66, Issue:2

    Topics: 5-Hydroxytryptophan; Adult; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myoclonus; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists; Syndrome

1982
Paroxetine: pharmacokinetics and cardiovascular effects after oral and intravenous single doses in man.
    Acta pharmacologica et toxicologica, 1982, Volume: 51, Issue:4

    Topics: Administration, Oral; Adult; Biological Availability; Half-Life; Hemodynamics; Humans; Injections, Intravenous; Kinetics; Male; Paroxetine; Piperidines

1982
An early clinical phase II evaluation of paroxetine, a new potent and selective 5HT-uptake inhibitor in patients with depressive illness.
    Pharmacopsychiatria, 1982, Volume: 15, Issue:6

    Topics: Adult; Aged; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Serotonin

1982
Effects of bretylium and guanethidine on 3H-noradrenaline and 3H-serotonin release in rat brain cortex slices.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 261, Issue:2

    Topics: Animals; Bretylium Compounds; Cerebral Cortex; Electric Stimulation; Guanethidine; In Vitro Techniques; Male; Neurons; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin

1983
Imipramine binding site. Temperature dependence of the binding of 3H-labeled imipramine and 3H-labeled paroxetine to human platelet membrane.
    Biochimica et biophysica acta, 1984, Feb-29, Volume: 770, Issue:1

    Topics: Binding Sites; Blood Platelets; Cell Membrane; Humans; Imipramine; Kinetics; Mathematics; Paroxetine; Piperidines; Temperature

1984
High affinity binding of [3H]paroxetine and [3H]imipramine to human platelet membranes.
    European journal of pharmacology, 1983, Dec-23, Volume: 96, Issue:3-4

    Topics: Antidepressive Agents, Tricyclic; Blood Platelets; Cell Membrane; Humans; Imipramine; Kinetics; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin Antagonists

1983
Acute or chronic changes of noradrenergic transmission do not affect the alpha-adrenoceptor-mediated inhibition of 3H-serotonin release in the cerebral cortex.
    Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 320, Issue:1

    Topics: Animals; Cerebral Cortex; Desipramine; Drug Interactions; Guanethidine; Hydroxydopamines; Male; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission

1982
Central and peripheral 5-HT uptake in rats treated chronically with femoxetine, paroxetine, and chlorimipramine.
    Psychopharmacology, 1980, Volume: 68, Issue:3

    Topics: Animals; Anisoles; Brain; Clomipramine; Diet; Dioxolanes; Female; Male; Motor Activity; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Serotonin; Serotonin Antagonists

1980
Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors.
    European journal of pharmacology, 1994, Nov-03, Volume: 264, Issue:3

    Topics: 1-Naphthylamine; 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Analysis of Variance; Animals; Behavior, Animal; Brain; Citalopram; Dose-Response Relationship, Drug; Fenclonine; Fluoxetine; Fluvoxamine; Male; Mice; Paroxetine; Penbutolol; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Sertraline; Synaptosomes

1994
Automated determination of paroxetine and its main metabolite by column switching and on-line high-performance liquid chromatography.
    Therapeutic drug monitoring, 1994, Volume: 16, Issue:4

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Imipramine; Mixed Function Oxygenases; Paroxetine; Piperidines; Sensitivity and Specificity

1994
Behavioural effects of selective serotonin reuptake inhibitors following direct micro injection into the left red nucleus of the rat.
    Journal of psychopharmacology (Oxford, England), 1997, Volume: 11, Issue:1

    Topics: 1-Naphthylamine; Animals; Behavior, Animal; Chlorpromazine; Citalopram; Fluoxetine; Fluvoxamine; Guanidines; Haloperidol; Male; Microinjections; Motor Activity; Paroxetine; Piperidines; Posture; Rats; Rats, Sprague-Dawley; Receptors, sigma; Red Nucleus; Selective Serotonin Reuptake Inhibitors; Sertraline

1997
Donepezil and paroxetine: possible drug interaction.
    Journal of the American Geriatrics Society, 1999, Volume: 47, Issue:8

    Topics: Aged; Aggression; Akathisia, Drug-Induced; Antidepressive Agents, Second-Generation; Confusion; Diarrhea; Donepezil; Drug Interactions; Female; Flatulence; Humans; Indans; Male; Nootropic Agents; Paroxetine; Piperidines; Sleep Initiation and Maintenance Disorders

1999
Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia.
    International journal of antimicrobial agents, 2000, Volume: 14, Issue:3

    Topics: Antibodies, Monoclonal; Antidepressive Agents; Antipsychotic Agents; Cell Line; Flupenthixol; gag Gene Products, Human Immunodeficiency Virus; Gene Products, gag; HIV Antigens; HIV Core Protein p24; HIV-1; Humans; Immunohistochemistry; Paroxetine; Piperidines; Viral Proteins; Virus Replication

2000
Drug interactions and donepezil.
    Journal of the American Geriatrics Society, 2000, Volume: 48, Issue:5

    Topics: Antidepressive Agents, Second-Generation; Antifungal Agents; Cholinesterase Inhibitors; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Donepezil; Drug Interactions; Enzyme Inhibitors; Humans; Indans; Ketoconazole; Paroxetine; Piperidines

2000
Synthesis of enantiopure trans-3,4-disubstituted piperidines. An enantiodivergent synthesis of (+)- and (-)-paroxetine.
    The Journal of organic chemistry, 2000, May-19, Volume: 65, Issue:10

    Topics: Antidepressive Agents, Second-Generation; Indicators and Reagents; Paroxetine; Piperidines; Stereoisomerism

2000
Highly diastereoselective and enantioselective carbon-carbon bond formations in conjugate additions of lithiated N-Boc allylamines to nitroalkenes: enantioselective synthesis of 3,4- and 3,4,5-substituted piperidines including (-)-paroxetine.
    Journal of the American Chemical Society, 2001, Feb-07, Volume: 123, Issue:5

    Topics: Alkenes; Amines; Carbon; Paroxetine; Piperidines; Stereoisomerism

2001
Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons.
    Brain research, 2001, Dec-13, Volume: 922, Issue:1

    Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Amphetamines; Animals; Electric Stimulation; Electrophysiology; Fluorobenzenes; Idazoxan; Locus Coeruleus; Male; Neurons; Norepinephrine; Paroxetine; Patch-Clamp Techniques; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists

2001
Enzymatic resolution of trans-4-(4'-fluorophenyl)-3-hydroxymethylpiperidines, key intermediates in the synthesis of (-)-Paroxetine.
    The Journal of organic chemistry, 2001, Dec-28, Volume: 66, Issue:26

    Topics: Acetylation; Benzene Derivatives; Candida; Hydrolysis; Indicators and Reagents; Lipase; Magnetic Resonance Spectroscopy; Paroxetine; Piperidines; Solvents; Stereoisomerism

2001
Enantiomeric enrichment of (+)-(3R,4S)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by crystallization.
    Enantiomer, 2001, Volume: 6, Issue:6

    Topics: Crystallization; Humans; Magnetic Resonance Spectroscopy; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Stereoisomerism

2001
Vibrational circular dichroism spectroscopy study of paroxetine and femoxetine precursors.
    Biopolymers, 2002, Volume: 67, Issue:4-5

    Topics: Circular Dichroism; Models, Chemical; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors

2002
Anhydrides as acylating agents in the enzymatic resolution of an intermediate of (-)-Paroxetine.
    The Journal of organic chemistry, 2003, Apr-18, Volume: 68, Issue:8

    Topics: Acetylation; Anhydrides; Candida; Catalysis; Esterification; Indicators and Reagents; Lipase; Paroxetine; Piperidines; Solvents; Stereoisomerism

2003
Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate-early gene Arc in rat brain.
    Neuropharmacology, 2003, Volume: 44, Issue:7

    Topics: Aminopyridines; Animals; Apoptosis Regulatory Proteins; Benzopyrans; Brain Chemistry; Gene Expression; Male; Muscle Proteins; Paroxetine; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists

2003
Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT(1A) receptor antagonism/SSRI activities. Part 2.
    Bioorganic & medicinal chemistry letters, 2003, Jul-21, Volume: 13, Issue:14

    Topics: Guanosine 5'-O-(3-Thiotriphosphate); Indicators and Reagents; Paroxetine; Piperidines; Propanols; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Stereoisomerism; Structure-Activity Relationship

2003
Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus.
    International journal of antimicrobial agents, 2003, Volume: 22, Issue:3

    Topics: Biological Transport, Active; Drug Resistance, Multiple, Bacterial; Hydrogen-Ion Concentration; Membrane Potentials; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Staphylococcus aureus

2003
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3.
    Bioorganic & medicinal chemistry letters, 2003, Nov-17, Volume: 13, Issue:22

    Topics: Antidepressive Agents; Guanosine 5'-O-(3-Thiotriphosphate); Indicators and Reagents; Molecular Conformation; Molecular Structure; Paroxetine; Piperidines; Propanols; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Antagonists; Structure-Activity Relationship

2003
Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice.
    Journal of neurochemistry, 2004, Volume: 89, Issue:1

    Topics: Animals; Drug Administration Routes; Extracellular Fluid; Frontal Lobe; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Neurokinin-1 Receptor Antagonists; Paroxetine; Perfusion; Piperidines; Raphe Nuclei; Receptors, Neurokinin-1; Selective Serotonin Reuptake Inhibitors; Serotonin; Tetrazoles

2004
Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps.
    Bioorganic & medicinal chemistry letters, 2004, Jun-21, Volume: 14, Issue:12

    Topics: Bacterial Proteins; Biological Transport, Active; Drug Resistance, Multiple, Bacterial; Paroxetine; Piperidines; Staphylococcus aureus; Structure-Activity Relationship

2004
Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats.
    British journal of pharmacology, 2005, Volume: 145, Issue:5

    Topics: Amantadine; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antiparkinson Agents; Clomipramine; Drug Synergism; Male; Microdialysis; Paroxetine; Piperidines; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin

2005
Convenient synthesis of substituted piperidinones from alpha,beta-unsaturated amides: formal synthesis of deplancheine, tacamonine, and paroxetine.
    The Journal of organic chemistry, 2005, May-13, Volume: 70, Issue:10

    Topics: Amides; Antidepressive Agents, Second-Generation; Indole Alkaloids; Paroxetine; Piperidines; Stereoisomerism

2005
Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT 1A autoreceptors in mice.
    Journal of neurochemistry, 2005, Volume: 95, Issue:6

    Topics: Animals; Autoradiography; Autoreceptors; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Neurokinin-1 Receptor Antagonists; Paroxetine; Piperidines; Raphe Nuclei; Receptor, Serotonin, 5-HT1A; Receptors, Neurokinin-1; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Tetrazoles

2005
Antidepressant-like activity of selective serotonin reuptake inhibitors combined with a NK1 receptor antagonist in the mouse forced swimming test.
    Behavioural brain research, 2006, Sep-25, Volume: 172, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antidepressive Agents; Citalopram; Depressive Disorder; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Escape Reaction; Male; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Swimming; Tetrazoles

2006
SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:10

    Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Benzoxazines; Brain; Callithrix; Drug Synergism; Male; Motor Activity; Paroxetine; Piperidines; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Social Behavior; Vocalization, Animal

2007
Stereospecific construction of substituted piperidines. Synthesis of (-)-paroxetine and (+)-laccarin.
    Chemical communications (Cambridge, England), 2007, Feb-21, Issue:7

    Topics: Indoles; Paroxetine; Piperidines; Stereoisomerism; Sulfonic Acids

2007
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants.
    Psychopharmacology, 2007, Volume: 195, Issue:1

    Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drugs, Investigational; Fluoxetine; Guinea Pigs; Injections, Intraperitoneal; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Swimming; Tranylcypromine

2007
The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration.
    Journal of neurochemistry, 2009, Volume: 109, Issue:5

    Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Brain; Citalopram; Depression; Disease Models, Animal; Fenclonine; Fenfluramine; Fluorobenzenes; Freezing Reaction, Cataleptic; Male; Paroxetine; Piperidines; Protein Binding; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT4; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Swimming; Time Factors; Tritium

2009
Comments on "An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606 in patients with treatment-refractory major depressive disorder".
    Journal of clinical psychopharmacology, 2009, Volume: 29, Issue:4

    Topics: Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Drug Resistance; Excitatory Amino Acid Antagonists; Humans; Infusions, Intravenous; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Research Design; Sigma-1 Receptor; Treatment Outcome

2009
NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test.
    Psychopharmacology, 2009, Volume: 206, Issue:2

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Immobility Response, Tonic; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Paroxetine; Piperidines; Receptors, N-Methyl-D-Aspartate; Swimming

2009
Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels.
    Neuroscience letters, 2010, May-31, Volume: 476, Issue:2

    Topics: Aniline Compounds; Animals; Drug Synergism; Extracellular Space; Hippocampus; Hydroxyindoleacetic Acid; Male; Microdialysis; Paroxetine; Piperidines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT4 Receptor Agonists

2010
Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors.
    Behavioural pharmacology, 2010, Volume: 21, Issue:4

    Topics: Animals; Behavior, Animal; Cannabidiol; Diazepam; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Mice; Mice, Inbred C57BL; Motor Activity; Paroxetine; Piperazines; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Synaptic Transmission

2010
Influence of GIRK channel inhibition on alcohol abstinence and relapse risk in Japanese alcohol-dependent outpatients.
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2011, Volume: 31, Issue:2

    Topics: Alcoholism; Analysis of Variance; Asian People; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Haloperidol; Humans; Middle Aged; Outpatients; Paroxetine; Piperidines; Retrospective Studies; Risk; Secondary Prevention; Treatment Outcome

2011
Optically pure γ-butyrolactones and epoxy esters via two stereocentered HKR of 3-substituted epoxy esters: a formal synthesis of (-)-paroxetine, Ro 67-8867 and (+)-eldanolide.
    Organic & biomolecular chemistry, 2013, Feb-28, Volume: 11, Issue:8

    Topics: 4-Butyrolactone; Alkadienes; Catalysis; Epoxy Compounds; Esters; Hydrolysis; Kinetics; Molecular Structure; Optical Phenomena; Organometallic Compounds; Paroxetine; Piperidines; Stereoisomerism

2013
The chemical fate of paroxetine metabolites. Dehydration of radicals derived from 4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine.
    Organic & biomolecular chemistry, 2013, Jul-07, Volume: 11, Issue:25

    Topics: Alkenes; Free Radicals; Imines; Paroxetine; Photolysis; Piperidines; Quantum Theory; Selective Serotonin Reuptake Inhibitors; Thermodynamics; Water

2013
Complexities of personalized medicine: how genes, drug-drug interactions, dosing schedules, and other factors can combine to produce clinically meaningful differences in a drug's effect.
    Journal of psychiatric practice, 2013, Volume: 19, Issue:5

    Topics: Affective Disorders, Psychotic; Aged; Antipsychotic Agents; Depressive Disorder, Major; Dizziness; Drug Interactions; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Isoxazoles; Male; Paroxetine; Pharmacogenetics; Piperidines; Precision Medicine

2013
Co-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:9

    Topics: Administration, Intravenous; Administration, Oral; Animals; Body Fluids; Carbamates; Cell Separation; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Feces; Hepatocytes; Intestinal Absorption; Liver; Male; Paroxetine; Piperidines; Pravastatin; Rats, Sprague-Dawley; Tissue Distribution

2015
Enantioselective Synthesis of Chiral Piperidines via the Stepwise Dearomatization/Borylation of Pyridines.
    Journal of the American Chemical Society, 2016, Apr-06, Volume: 138, Issue:13

    Topics: Antidepressive Agents; Catalysis; Dihydropyridines; Molecular Structure; Paroxetine; Piperidines; Pyridines; Stereoisomerism

2016
Influence of the selective antagonist of the NR2B subunit of the NMDA receptor, traxoprodil, on the antidepressant-like activity of desipramine, paroxetine, milnacipran, and bupropion in mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2017, Volume: 124, Issue:3

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Brain; Bupropion; Chromatography, High Pressure Liquid; Cyclopropanes; Depressive Disorder; Desipramine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Male; Mice; Milnacipran; Motor Activity; Paroxetine; Piperidines; Receptors, N-Methyl-D-Aspartate

2017