paroxetine has been researched along with piperidines in 292 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 127 (43.49) | 18.7374 |
| 1990's | 123 (42.12) | 18.2507 |
| 2000's | 29 (9.93) | 29.6817 |
| 2010's | 13 (4.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jørgensen, OS; Mellerup, ET; Plenge, P | 1 |
| Carli, M; Dewar, KM; Grondin, L; Lima, L; Reader, TA | 1 |
| Dwork, A; Huang, YY; Parsons, B; Roxas, A; Stanley, M | 1 |
| Katz, JL; Martello, AL; Martello, MB; Ricaurte, GA | 1 |
| Chen, JC; Schnepper, PW; To, A; Volicer, L | 1 |
| Culp, S; DeSouza, EB; Lehmann, J; Zaczek, R | 1 |
| Andersson, A; Marcusson, J; Sundman, I | 1 |
| Möller, HJ; Steinmeyer, EM | 1 |
| Abraham, P; Carroll, FI; Cline, EJ; Dannals, RF; Kuhar, MJ; Lewin, AH; Ricaurte, GA; Scheffel, U | 1 |
| Bach, FW; Gram, LF; Sindrup, SH | 1 |
| Block, P; Fieve, RR; Peselow, ED; Robins, CJ; Sanfilipo, MP | 1 |
| Artigas, F; Ortiz, J | 1 |
| Dunbar, GC; Fuell, DL; Sheehan, D | 1 |
| Edwards, E; Henn, FA; Houtten, PV; Kornrich, W | 1 |
| Bloomer, JC; Haddock, RE; Lennard, MS; Tucker, GT; Woods, FR | 1 |
| Difiglia, C; Fieve, RR; Peselow, ED; Sanfilipo, MP | 1 |
| Emilsson, K; Hardebo, JE; Nystedt, S; Owman, C; Szabò, C | 1 |
| DeVane, CL | 1 |
| Dunbar, GC; Dunner, DL | 1 |
| Kiev, A | 1 |
| Boyer, WF; Feighner, JP | 3 |
| Amsterdam, J; Clary, C; Fox, I; Rickels, K; Schweizer, E; Weise, C | 2 |
| Claghorn, JL | 1 |
| Glaudin, V; Smith, WT | 1 |
| Fabre, LF | 1 |
| Blumhardt, CL; Overweg, N; Shrivastava, RK; Shrivastava, SH | 1 |
| Cohn, JB; Wilcox, CS | 1 |
| Cohn, CK; Cohn, JB; Dunner, DL; Feighner, JP; Fieve, RR; Halikas, JP; Hartford, JT; Hearst, ED; Settle, EC; Walshe, T | 1 |
| Blumhardt, CL; Boyer, WF | 1 |
| Johnson, AM; Tulloch, IF | 1 |
| Allen, A; Allen, GD; Brøsen, K; Cooper, SM; Gram, LF; Hallas, J; Mellows, G; Sindrup, SH; Skjelbo, E; Tasker, TC | 1 |
| Brøsen, K; Gram, LF; Sindrup, SH | 1 |
| Karnovsky, ML; Polanski, M | 1 |
| Goodman, WK; McDougle, CJ; Price, LH | 1 |
| McGuirk, J; Muscat, R; Willner, P | 1 |
| Alouf, JE; Buckle, M; Cesura, A; Da Prada, M; Geoffroy, C; Launay, JM; Mutel, V | 1 |
| Kuhs, H; Rolf, LH; Rudolf, GA; Schlake, HP | 1 |
| Bell, J; Whitaker-Azmitia, PM; Zhang, XN | 1 |
| Akbari, HM; Azmitia, EC; Kramer, HK; Spear, LP; Whitaker-Azmitia, PM | 1 |
| Ben-Zeev, A; Lerer, B; Newman, ME | 1 |
| Anzini, M; Cagnotto, A; Campiani, G; Cappelli, A; Skorupska, M; Vomero, S | 1 |
| Colpaert, FC; Millan, MJ | 1 |
| Bowery, NG; Johnson, AM; Nelson, DR; Palmer, KJ; Pratt, GD | 1 |
| Battaglia, G; de Souza, EB; Kuhar, MJ; Sharkey, J | 1 |
| Kelly, PA; McBean, DE; Sharkey, J | 1 |
| Goromaru, T; Hashimoto, K | 3 |
| Max, MB | 1 |
| Arora, RC; Meltzer, HY; Nash, JF; Schreiber, MA | 1 |
| Hill, DR; Stoessl, AJ | 1 |
| Clissold, SP; Dechant, KL | 1 |
| Garattini, S; Mennini, T | 1 |
| Descarries, L; Dewar, KM; Grondin, L; Reader, TA | 1 |
| Dannals, RF; Ravert, HT; Scheffel, U; Suehiro, M; Wagner, HN; Wilson, AA | 1 |
| Mellerup, ET; Plenge, P | 6 |
| Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH; Philip, A; Rahman, MA | 1 |
| Edwards, E; Harkins, K; Henn, F; Wright, G | 1 |
| Badawy, AA; Morgan, CJ | 1 |
| Johnson, MP; Nichols, DE; Oberlender, R | 1 |
| Boucly, P; Breton, P; Daoust, M; Ernouf, D; Legrand, E; Lhuintre, JP | 1 |
| Esnaud, H; Graham, D; Langer, SZ | 1 |
| Guan, XM; McKenna, DJ; Shulgin, AT | 1 |
| Eglen, RM; Loury, DN; Michel, AD; Sharif, NA; Stefanich, E; Whiting, RL; Wong, EH | 1 |
| Laursen, H; Mellerup, ET; Plenge, P | 2 |
| Bengtsson, BO; Lundmark, J; Wålinder, J | 1 |
| Elbaz, E; Glaser, R; Jensen, PN; Mikkelsen, EO; Poulsen, SH; Smith, DF | 1 |
| Akunne, H; deCosta, BR; Jacobson, AE; Rice, KC; Rothman, RB | 1 |
| Egashira, T; Goto, S; Yamanaka, Y | 1 |
| Larsen, T; Manniche, PM; Morsing, I; Møller, SE; Nielsen, OA; Petersen, JS; Skausig, OB | 1 |
| Beck-Nielsen, H; Gram, LF; Grodum, E; Sindrup, SH | 1 |
| Cohn, JB; Dunbar, GC; Fabre, LF; Feighner, JP; Fieve, RR; Mendels, J; Shrivastava, RK | 1 |
| Briley, M; Moret, C | 2 |
| Casanova, MF; Chen, HT; Goldman, D; Kleinman, JE; Linnoila, M; Zito, M | 1 |
| Dam, H; Lauritzen, L; Mellerup, ET; Plenge, P | 1 |
| Anderer, P; Frey, R; Grünberger, J; Krupka, M; Saletu, B; See, WR | 1 |
| Blier, P; Chaput, Y; de Montigny, C | 1 |
| Almdal, TP; Bjerrum, K; Dalhoff, K; Keiding, S; Lund, J; Mengel, H | 1 |
| Baldwin, D; Bullock, T; Montgomery, D; Montgomery, S | 1 |
| Brewster, WK; Johnson, MP; Nichols, DE; Oberlender, R; Riggs, RM | 1 |
| Hekmatpanah, CR; Peroutka, SJ | 1 |
| Peroutka, SJ; Wagner, J | 1 |
| Bird, ED; Crino, PB; Plager, MD; Vogt, BA | 1 |
| Johnson, AM; Nelson, DR; Palmer, KJ | 1 |
| Ricaurte, GA; Scheffel, U | 1 |
| Bech, P; Bjerrum, H; Butler, B; Bøjholm, S; Folker, H; Gram, LF; Larsen, JK; Lauritzen, L; Loldrup, D; Møller, SE | 1 |
| Foy, B; Hepner, A; Hrdina, PD; Summers, RJ | 1 |
| Insel, TR; Winslow, JT | 1 |
| Crino, PB; Vogt, BA; Volicer, L; Wiley, RG | 1 |
| Koe, BK; Lebel, LA; Welch, WM | 1 |
| Johnson, MP; Nichols, DE | 2 |
| Briley, M; Chopin, P; Moret, C | 1 |
| Cool, DR; Ganapathy, V; Leibach, FH | 1 |
| Aronstam, RS; Introna, RP; Martin, DC | 1 |
| Appel, NM; Contrera, JF; De Souza, EB; Mitchell, WM | 1 |
| Fekkes, D; Klompenhouwer, JL; Moleman, P; Mulder, PG; Pepplinkhuizen, L; van Hulst, AM | 1 |
| Cheetham, SC; Crompton, MR; De Paermentier, F; Horton, RW; Katona, CL; Lawrence, KM | 3 |
| Cohn, JB; Crowder, JE; Ryan, PJ; Wilcox, CS | 1 |
| Cool, DR; Ganapathy, V; Liebach, FH | 1 |
| Strijewski, A; Tang, SW | 1 |
| Brøsen, K; Eshøj, O; Gram, LF; Mogensen, EF; Sindrup, SH | 1 |
| Kuhs, H; Rudolf, GA | 2 |
| Mellerup, ET; Nielsen, M; Plenge, P | 2 |
| Rickels, K; Schweizer, E | 1 |
| Westwick, F | 1 |
| Bertocci, B; Cesura, AM; Da Prada, M | 1 |
| Quartermain, D; Shemer, AV; Whitaker-Azmitia, PM | 1 |
| Egashira, T; Goto, S; Murayama, F; Yamanaka, Y | 1 |
| Blier, P; Galzin, AM; Langer, SZ | 1 |
| Battaglia, G; De Souza, EB; Kuhar, MJ; Molliver, ME; O'Hearn, E; Yeh, SY | 1 |
| Brunello, N; Galimberti, R; Racagni, G; Riva, M; Rovescalli, AC | 1 |
| Herrick-Davis, K; Maisonneuve, IM; Titeler, M | 1 |
| Hartig, PR; Scheffel, U | 1 |
| Edwards, JG; Goldie, A; Papayanni-Papasthatis, S | 1 |
| Bäckström, I; Bergström, M; Marcusson, J | 1 |
| Buus Lassen, J | 1 |
| Koshikawa, N; Maruyama, Y; Stephenson, JD | 1 |
| De Oliveira, AM; Langer, SZ; Schoemaker, H; Segonzac, A | 1 |
| Andersson, A; Bäckström, I; Marcusson, JO | 1 |
| Galzin, AM; Langer, SZ; Rocca, P | 1 |
| Anzini, M; Cagnotto, A; Cappelli, A; Garofalo, A; Vomero, S | 1 |
| Furuya, Y; Iwasaki, K; Minamoto, Y; Miyamoto, K; Ohno, M; Shibata, S; Shimazoe, T; Ueki, S; Watanabe, S; Yamamoto, T | 1 |
| Bannister, SJ; Houser, VP; Hulse, JD; Kisicki, JC; Rasmussen, JG | 1 |
| Montgomery, SA | 1 |
| Edwards, JG; Goldie, A; Papayanni-Papasthatis, S; Punter, J; Sedgwick, EM | 1 |
| Lassen, JB | 1 |
| Fourie, J; Gagiano, CA; Le Roux, JF; Müller, PG | 1 |
| Archambault, JC; Chabannes, JP; Clerc, G; Desvilles, M; Guibert, M; Guillibert, E; Pagot, R; Pelicier, Y; Poisat, JL; Thobie, Y | 1 |
| Dunbar, GC | 1 |
| Byrne, MM | 1 |
| Johnson, AM | 1 |
| Mertens, C; Pintens, H | 2 |
| Bascara, L | 1 |
| Miller, SM; Murtagh, M; Naylor, GJ; Winslow, G | 1 |
| Brune, GG; Husstedt, IW; Kuhs, H; Rudolf, GA | 1 |
| Bosse, T; Brune, GG; Kuhs, H; Rolf, LH; Rudolf, GA; Schlake, HP; Schuhknecht, E | 1 |
| Kaye, CM; Link, CG; Tasker, TC; Zussman, BD | 1 |
| Buscher, G; Dierdorf, HD; Greb, WH; von Schrader, HW; Wolf, D | 1 |
| Johnson, AM; Nelson, DR; Thomas, DR | 2 |
| Haddock, RE; Johnson, AM; Langley, PF; Nelson, DR; Pope, JA; Thomas, DR; Woods, FR | 1 |
| Cain, CR; Hamilton, TC; Norton, J; Petersen, EN; Poyser, RH; Thormählen, D | 1 |
| Hakansson, S; Kelvin, AS | 1 |
| Kelvin, AS; Mitchell, ID; White, DJ | 1 |
| Baldwin, JA; Davidson, EJ; Pritchard, AL; Ridings, JE | 1 |
| Dewdney, JM; Edwards, RG; Henderson, DC; Weston, BJ | 2 |
| de Vries, J; Deijen, JB; Loriaux, SM; Orlebeke, JF | 1 |
| Dana-Haeri, J; Sinclair, AJ; Warrington, SJ | 1 |
| Harrison, C; Hindmarch, I | 1 |
| Jackson, D; McClelland, GR; Raptopoulos, P | 2 |
| Hassan, SM; Turner, P; Wainscott, G | 2 |
| Cooper, SM; Jackson, D; Loudon, JM; McClelland, GR; Raptopoulos, P | 1 |
| Laruelle, M; Maloteaux, JM | 1 |
| Greb, WH; Haddock, RE; Kaye, CM; Langley, PF; Mellows, G; Tasker, TC; Zussman, BD | 1 |
| Fjord-Larsen, T; Lundmark, J; Manniche, PM; Mengel, H; Møller-Nielsen, EM; Pauser, H; Scheel Thomsen, I; Wålinder, J | 1 |
| Dunbar, GC; Fellerer, K; Hebenstreit, GF; Zentz, A; Zöchling, R | 1 |
| Allen, EA; Bayer, AJ; Byrne, MM; Clarkson, A; Horan, M; Roberts, NA; Routledge, PA; Swift, CG; Zussman, BD | 1 |
| Ghose, K | 1 |
| Byrne, MM; Clarkson, A; Doyle, GD; Kelly, JG; Laher, M; Zussman, BD | 1 |
| Dierdorf, HD; Eckl, KM; Greb, WH; Krastev, Z; Maleev, A; Terziivanov, D; Vlahov, V; Wolf, D | 1 |
| Haddock, RE; Jackson, D; Woods, FR | 1 |
| Buscher, G; Dierdorf, HD; Greb, WH; Köster, FE; Mellows, G; Wolf, D | 1 |
| Brett, MA; Buscher, G; Dierdorf, HD; Greb, WH; Mellows, G; von Schrader, HW; Wolf, D; Zussman, BD | 1 |
| Esnaud, H; Graham, D; Habert, E; Langer, SZ | 1 |
| Barouche, F; Fieve, RR; Filippi, AM; Goodnick, P; Peselow, ED | 2 |
| Barouche, F; Fieve, RR; Filippi, AM; Goodnick, P; Peselow, ED; Stanley, M | 1 |
| Hurt, SD; Peroutka, SJ; Schmidt, AW | 1 |
| Andersson, A; Marcusson, J | 1 |
| Beani, L; Bianchi, C; Siniscalchi, A | 1 |
| Hekmatpanah, CR; McKenna, DJ; Peroutka, SJ | 1 |
| Gleiter, CH; Nutt, DJ | 2 |
| Galzin, AM; Langer, SZ; Moret, C; Verzier, B | 1 |
| Cross, AJ; Reynolds, GP; Slater, P | 1 |
| Honoré, PL; Honoré, T; Mellerup, ET; Plenge, P | 1 |
| Dubicki, W; Goudie, AJ; Leathley, M | 1 |
| Claustre, Y; Graham, D; Habert, E; Langer, SZ; Tahraoui, L | 1 |
| Koshikawa, F; Koshikawa, N; Stephenson, JD | 1 |
| Fuller, RW | 1 |
| Asberg, M; Eriksson, B; Mårtensson, B; Träskman-Bendz, L; Wägner, A | 1 |
| Agid, Y; Cash, R; Raisman, R | 1 |
| Smith, DF | 1 |
| Hamilton, TC; Norton, J; Poyser, RH; Thormählen, D | 1 |
| Graham, D; Habert, E; Langer, SZ | 1 |
| Adam, K; Oswald, I | 1 |
| Langer, SZ; Schoemaker, H; Segonzac, A | 1 |
| Mellerup, ET; Plenge, P; Rafaelsen, OJ | 1 |
| Graham, D; Langer, SZ; Tahraoui, L | 1 |
| Brett, MA; Coates, PE; Dierdorf, HD; Zussman, BD | 1 |
| Aoki, S; Kobayashi, M; Koshikawa, N; Stephenson, JD | 1 |
| Ishikura, Y; Ono, H; Yokota, S | 1 |
| Galzin, AM; Langer, SZ | 1 |
| Burki, HR; Kleinlogel, H | 1 |
| Bergström, M; Eriksson, K; Marcusson, JO; Ross, SB | 1 |
| Furuya, Y; Man'no, K; Ohno, M; Ohta, H; Sugihara, K; Tani, Y; Ueki, S; Watanabe, S | 1 |
| Laruelle, M; Maloteaux, JM; Vanisberg, MA | 1 |
| Eriksson, K; Marcusson, J | 1 |
| Kobayashi, M; Koshikawa, N; Maruyama, Y; Mori, E; Nomura, H; Oka, K; Stephenson, JD | 1 |
| De Souza, EB; Kuyatt, BL | 1 |
| Cortés, R; Palacios, JM; Pazos, A; Probst, A; Soriano, E | 1 |
| Yoshida, Y | 1 |
| D'haenen, H; De Waele, M; Leysen, JE | 1 |
| Barnas, C; Fleischhacker, WW; Hinterhuber, H; Mair, M; Schifferle, I; Schubert, H; Stuppäck, C; Unterweger, B; Wömhart, L | 1 |
| Magnussen, I | 1 |
| Galzin, AM; Langer, SZ; Lee, CR; Taranger, MA | 1 |
| Ichida, S; Manno, K; Miki, N; Sugihara, K; Tanigaki, N; Yoshida, H | 1 |
| Galzin, AM; Langer, SZ; Loo, H; Poirier, MF; Sechter, D; Zarifian, E | 1 |
| Laursen, AL; le Fèvre Honoré, P; Mikkelsen, PL; Rasmussen, S | 1 |
| Koshikawa, N; Smokcum, RW; Stephenson, JD | 1 |
| Battegay, R; Hager, M; Rauchfleisch, U | 1 |
| Engbaek, F; Lademann, A; Magnussen, I; Mondrup, K; Olivarius, BD | 1 |
| Gram, LF; Kristensen, CB; Lund, J; Mengel, H; Pedersen, OL; Thayssen, P | 1 |
| Børup, C; le Fèvre Honoré, P; Meidahl, B; Petersen, IM; Vangtorp, A | 1 |
| Göthert, M; Schlicker, E | 1 |
| Engelstoft, M; Mellerup, ET; Plenge, P | 1 |
| McClelland, GR; Raptopoulos, P | 1 |
| Clausing, R; Göthert, M; Schlicker, E | 1 |
| Lassen, JB; Lund, J; Søndergaard, I | 1 |
| Hyttel, J; Sánchez, C | 1 |
| Härtter, S; Hermes, B; Hiemke, C; Szegedi, A | 1 |
| Feldtrauer, JJ; Germer, M; Graf, T; Howald, H; Waldmeier, PC | 1 |
| Earley, B; Faherty, CJ; Leonard, BE | 1 |
| Stein, MB | 1 |
| Carrier, L | 1 |
| Hansen, JB; Kristiansen, JE | 1 |
| Rojas-Fernandez, C | 1 |
| Amat, M; Bosch, J; Cantó, M; Hidalgo, J; Llor, N; Luque, J; Miravitlles, C; Molins, E; Orozco, M; Pérez, M | 1 |
| Schneier, FR | 1 |
| Beak, P; Curtis, MD; Johnson, TA | 1 |
| Blier, P; Szabo, ST | 1 |
| Bayod, M; Brieva, R; de Gonzalo, G; Gotor, V; Sánchez, VM | 2 |
| Navrátilová, H; Potácek, M | 1 |
| Bour, P; Navrátilová, H; Setnicka, V; Urbanová, M; Volka, K | 1 |
| Gray, K; Newson, M; Pei, Q; Sharp, T; Sprakes, M; Tordera, R | 1 |
| Ahmad, LJ; Atkinson, ST; Hertel, LW; Honigschmidt, NA; Koch, DJ; Kohn, TJ; Nelson, DL; Rocco, VP; Shaw, J; Spinazze, PG; Takeuchi, K; Threlkeld, PG; Wainscott, DB; Wong, DT | 1 |
| Hansen, JB; Kaatz, GW; Kristiansen, JE; Moudgal, VV; Seo, SM | 1 |
| Ahmad, LJ; Atkinson, ST; Hertel, LW; Honigschmidt, NA; Kohn, TJ; Nelson, DL; Rocco, VP; Shaw, J; Spinazze, PG; Takeuchi, K; Threlkeld, PG; Wainscott, DB; Wong, DT | 1 |
| De Felipe, C; Froger, N; Gardier, AM; Guiard, BP; Guilloux, JP; Hunt, SP; Lanfumey, L; Przybylski, C; Seif, I | 1 |
| Kaatz, GW; Kerns, RJ; Wei, P | 1 |
| Cossy, J | 1 |
| Owen, JC; Whitton, PS | 1 |
| Ihara, M; Nishida, N; Takasu, K; Tomimura, A | 1 |
| Froger, N; Gardier, AM; Guiard, BP; Hamon, M; Lanfumey, L | 1 |
| Bourin, M; Chenu, F; Gardier, AM; Guiard, BP | 1 |
| de Boissezon, X; de Boysson, C; Démonet, JF; Peran, P | 1 |
| Arban, R; Atkinson, PJ; Dawson, LA; Duxon, MS; Hagan, JJ; Melotto, S; Price, GW; Starr, KR; Upton, N; Watson, JM | 1 |
| Bower, JF; Gallagher, T; Riis-Johannessen, T; Szeto, P; Whitehead, AJ | 1 |
| Gross, G; Groth, I; Jongen-Relo, A; Rex, A; Wicke, KM | 1 |
| Baker, B; Kolluri, S; Krams, M; Landen, JW; Menniti, FS; Preskorn, SH | 1 |
| Aznar, S; Knudsen, GM; Licht, CL; Marcussen, AB; Overstreet, DH; Wegener, G | 1 |
| Hashimoto, K | 1 |
| Dehpour, AR; Ebrahimi, F; Ghasemi, M; Montaser-Kouhsari, L; Nezami, BG; Shafaroodi, H | 1 |
| Knudsen, GM; Licht, CL; Sharp, T | 1 |
| Casarotto, PC; Gomes, FV; Guimarães, FS; Resstel, LB | 1 |
| Asukai, N; Haraguchi, A; Hori, T; Ikeda, K; Ogai, Y; Senoo, E | 1 |
| Baguley, DM; Dewit, O; Fina, P; Inamdar, A; Kitchiner, P; Koch, A; McFerran, DJ; Merlo-Pich, E; Roberts, C | 1 |
| Archer, G; Bellew, K; Bettica, P; Bryson, H; Bye, A; Fernandes, S; Krishnan, KR; Ratti, E; Squassante, L; Trist, D; Zamuner, S | 1 |
| Hochfeld, M; Meng, X; Potkin, SG; Preskorn, S | 1 |
| Devalankar, DA; Karabal, PU; Sudalai, A | 1 |
| Achrainer, F; Šakić, D; Vrček, V; Zipse, H | 1 |
| Preskorn, SH | 1 |
| Li, F; Ling, Z; Liu, C; Liu, L; Liu, X; Shu, N; Xu, D; Zhang, M; Zhong, Z | 1 |
| Hayama, K; Ito, H; Kubota, K; Watanabe, Y | 1 |
| Bernardo, BC; Blaxall, BC | 1 |
| Dudka, J; Poleszak, E; Serefko, A; Stasiuk, W; Świąder, K; Szopa, A; Wlaź, P; Wyska, E | 1 |
24 review(s) available for paroxetine and piperidines
| Article | Year |
|---|---|
Melancholic/endogenous depression and response to somatic treatment and placebo.
Topics: Antidepressive Agents; Depressive Disorder; Double-Blind Method; Fluoxetine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Placebos; Prospective Studies; Psychiatric Status Rating Scales; Treatment Outcome | 1992 |
Pharmacokinetics of the selective serotonin reuptake inhibitors.
Topics: 1-Naphthylamine; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Serotonin Antagonists; Sertraline | 1992 |
Optimal dose regimen for paroxetine.
Topics: Administration, Oral; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Multicenter Studies as Topic; Paroxetine; Piperidines | 1992 |
An overview of paroxetine.
Topics: Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Humans; Nausea; Paroxetine; Piperidines; Serotonin Antagonists | 1992 |
The safety profile of paroxetine.
Topics: Adult; Aged; Antidepressive Agents; Bipolar Disorder; Cardiovascular System; Clinical Trials as Topic; Depressive Disorder; Drug Interactions; Electrocardiography; Female; Humans; Male; Middle Aged; Neurocognitive Disorders; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Psychomotor Performance; Sleep | 1992 |
The pharmacologic profile of paroxetine, a new selective serotonin reuptake inhibitor.
Topics: 1-Naphthylamine; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; In Vitro Techniques; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Serotonin Antagonists; Sertraline | 1992 |
Pharmacotherapy of obsessive compulsive disorder.
Topics: 1-Naphthylamine; Antidepressive Agents; Clomipramine; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Neurotransmitter Uptake Inhibitors; Obsessive-Compulsive Disorder; Paroxetine; Piperidines; Serotonin; Sertraline | 1992 |
Paroxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness.
Topics: Amitriptyline; Animals; Antidepressive Agents; Clomipramine; Depressive Disorder; Drug Evaluation; Drug Tolerance; Humans; Imipramine; Paroxetine; Piperidines; Serotonin Antagonists | 1991 |
[Neurobiology of tianeptine. A new pharmaceutic agent].
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cerebral Cortex; Cyclic AMP; Hippocampus; Hydroxyindoleacetic Acid; Hypothalamus; Injections, Intraperitoneal; Paroxetine; Piperidines; Rats; Serotonin; Thiazepines | 1991 |
5-HT reuptake inhibitors, tricyclic antidepressants and suicidal behaviour.
Topics: Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Fluoxetine; Fluvoxamine; Humans; Mianserin; Paroxetine; Piperidines; Serotonin Antagonists; Suicide; Suicide Prevention | 1991 |
Clinical overview of serotonin reuptake inhibitors.
Topics: 1-Naphthylamine; Antidepressive Agents, Tricyclic; Depressive Disorder; Fluoxetine; Humans; Paroxetine; Piperidines; Serotonin Antagonists; Sertraline; Zimeldine | 1990 |
Depression and selective serotonin reuptake inhibitors.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Depression; Fluoxetine; Humans; Imipramine; Meta-Analysis as Topic; Middle Aged; Multicenter Studies as Topic; Paroxetine; Piperidines; Serotonin Antagonists | 1990 |
New antidepressants and 5-HT uptake inhibitors.
Topics: Antidepressive Agents; Depressive Disorder; Humans; Long-Term Care; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
An interim overview of the safety and tolerability of paroxetine.
Topics: Antidepressive Agents; Clinical Trials as Topic; Humans; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
An overview of the animal pharmacology of paroxetine.
Topics: Animals; Antidepressive Agents; Arousal; Brain; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin Antagonists | 1989 |
A review of the metabolism and pharmacokinetics of paroxetine in man.
Topics: Antidepressive Agents; Depressive Disorder; Drug Interactions; Humans; Metabolic Clearance Rate; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
Biochemical pharmacology of the serotonin system.
Topics: Alanine; Brain; Citalopram; Clomipramine; Fenfluramine; Fluoxetine; Fluvoxamine; Humans; Monoamine Oxidase Inhibitors; Neurons; Oximes; p-Chloroamphetamine; Paroxetine; Piperidines; Propylamines; Receptors, Serotonin; Reserpine; Serotonin; Serotonin Antagonists; Synapses; Tetrabenazine; Zimeldine | 1986 |
Therapeutic effects of serotonin uptake inhibitors in depression.
Topics: 5-Hydroxytryptophan; Alanine; Citalopram; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Propylamines; Serotonin; Serotonin Antagonists; Trazodone; Zimeldine | 1986 |
Studies on the serotonin transporter in platelets.
Topics: Animals; Antidepressive Agents, Tricyclic; Binding Sites; Blood Platelets; Carrier Proteins; Humans; Imipramine; Paroxetine; Piperidines; Serotonin Antagonists | 1988 |
Medication treatments for panic disorder and social phobia.
Topics: Antidepressive Agents, Tricyclic; Benzamides; Benzodiazepines; Citalopram; Clinical Trials as Topic; Clomipramine; Clonazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Moclobemide; Monoamine Oxidase Inhibitors; Panic Disorder; Paroxetine; Piperidines; Recurrence; Selective Serotonin Reuptake Inhibitors; Social Behavior Disorders | 1998 |
Treatment of social phobia with antidepressants.
Topics: Antidepressive Agents; Controlled Clinical Trials as Topic; Drug Approval; Humans; Moclobemide; Monoamine Oxidase Inhibitors; Paroxetine; Phenelzine; Phobic Disorders; Piperidines; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; United States | 2001 |
Selective methodologies for the synthesis of biologically active piperidinic compounds.
Topics: Alkaloids; Arginine; Chemistry; Dioxoles; Paroxetine; Pipecolic Acids; Piperidines; Pyrrolidines; Sulfonamides | 2005 |
Pharmacotherapy of aphasia: myth or reality?
Topics: Amphetamine; Aphasia; Bromocriptine; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dopamine Agents; Fluoxetine; GABA Agonists; Humans; Indans; Neuroprotective Agents; Paroxetine; Physostigmine; Piperidines; Piracetam; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin; Stroke; Zolpidem | 2007 |
From Bench to Bedside: New Approaches to Therapeutic Discovery for Heart Failure.
Topics: Angiotensin Receptor Antagonists; Cardiac Myosins; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclohexanes; G-Protein-Coupled Receptor Kinase 2; Heart Failure; Humans; Neprilysin; Oximes; Paroxetine; Piperidines; RNA, Untranslated; Xanthenes | 2016 |
63 trial(s) available for paroxetine and piperidines
| Article | Year |
|---|---|
Facet theoretic analysis of the Hamilton-D scale.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Factor Analysis, Statistical; Female; Humans; Male; Middle Aged; Models, Statistical; Paroxetine; Personality Inventory; Piperidines; Prospective Studies; Psychometrics; Serotonin Antagonists | 1992 |
Plasma beta-endorphin is not affected by treatment with imipramine or paroxetine in patients with diabetic neuropathy symptoms.
Topics: Adult; Aged; Antidepressive Agents; beta-Endorphin; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Paroxetine; Piperidines | 1992 |
Sociotropy and autonomy: relationship to antidepressant drug treatment response and endogenous-nonendogenous dichotomy.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Humans; Imipramine; Individuality; Internal-External Control; Interpersonal Relations; Male; Oximes; Paroxetine; Piperidines; Serotonin Antagonists | 1992 |
The effect of paroxetine on anxiety and agitation associated with depression.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Anxiety; Depressive Disorder; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales | 1992 |
Melancholic/endogenous depression and response to somatic treatment and placebo.
Topics: Antidepressive Agents; Depressive Disorder; Double-Blind Method; Fluoxetine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Placebos; Prospective Studies; Psychiatric Status Rating Scales; Treatment Outcome | 1992 |
A double-blind, placebo-controlled study of paroxetine in depressed outpatients.
Topics: Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drugs, Investigational; Humans; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Psychiatric Status Rating Scales | 1992 |
The efficacy and safety of paroxetine compared with placebo in outpatients with major depression.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Female; Humans; Male; Middle Aged; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Psychiatric Status Rating Scales | 1992 |
The safety and efficacy of paroxetine compared with placebo in a double-blind trial of depressed outpatients.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Psychiatric Status Rating Scales | 1992 |
A placebo-controlled trial of paroxetine in the treatment of major depression.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Female; Humans; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Patient Dropouts; Piperidines; Placebos; Psychiatric Status Rating Scales; Suicide; Time Factors | 1992 |
A 6-week, double-blind trial of paroxetine, imipramine, and placebo in depressed outpatients.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Patient Dropouts; Piperidines; Placebos; Psychiatric Status Rating Scales | 1992 |
Paroxetine in the treatment of depression: a comparison with imipramine and placebo.
Topics: Adolescent; Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Patient Dropouts; Piperidines; Placebos; Psychiatric Status Rating Scales | 1992 |
A double-blind comparison of paroxetine, imipramine, and placebo in major depression.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Patient Dropouts; Piperidines; Placebos; Prospective Studies; Psychiatric Status Rating Scales | 1992 |
Paroxetine in major depression: a double-blind trial with imipramine and placebo.
Topics: Adult; Antidepressive Agents; Anxiety Disorders; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Prospective Studies | 1992 |
Two combined, multicenter double-blind studies of paroxetine and doxepin in geriatric patients with major depression.
Topics: Age Factors; Aged; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Doxepin; Female; Humans; Male; Middle Aged; Neurotransmitter Uptake Inhibitors; Paroxetine; Patient Dropouts; Piperidines; Psychiatric Status Rating Scales | 1992 |
Relationship between parameters of serotonin transport and antidepressant plasma levels or therapeutic response in depressive patients treated with paroxetine and amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Platelets; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1992 |
Novel selective serotonin reuptake inhibitors, Part II.
Topics: Adult; Aged; Ambulatory Care; Depressive Disorder; Humans; Imipramine; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Placebos; Recurrence; Serotonin; Serotonin Antagonists | 1992 |
Paroxetine and imipramine treatment of depressive patients in a controlled multicentre study with plasma amino acid measurements.
Topics: Amino Acids; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Imipramine; Male; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Serotonin Antagonists | 1991 |
A comparison of paroxetine, imipramine and placebo in depressed out-patients.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Paroxetine; Personality Tests; Piperidines; Serotonin Antagonists | 1991 |
Sleep laboratory studies on the single-dose effects of serotonin reuptake inhibitors paroxetine and fluoxetine on human sleep and awakening qualities.
Topics: Adult; Arousal; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electroencephalography; Female; Fluoxetine; Humans; Male; Middle Aged; Monitoring, Physiologic; Paroxetine; Piperidines; Serotonin Antagonists; Sleep Stages; Wakefulness | 1991 |
Plasma ratio tryptophan/neutral amino acids in relation to clinical response to paroxetine and clomipramine in patients with major depression.
Topics: Adult; Aged; Amino Acids; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists; Tryptophan | 1990 |
Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. Danish University Antidepressant Group.
Topics: Adult; Antidepressive Agents; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Multicenter Studies as Topic; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Serotonin Antagonists | 1990 |
A placebo- and imipramine-controlled study of paroxetine.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Paroxetine; Piperidines; Psychiatric Status Rating Scales | 1990 |
The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms.
Topics: Depression; Desipramine; Diabetic Neuropathies; Humans; Imipramine; Nervous System; Osmolar Concentration; Paroxetine; Piperidines; Serotonin Antagonists; Time Factors | 1990 |
Cardiovascular effects of paroxetine.
Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Pressure; Double-Blind Method; Electrocardiography; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Paroxetine; Piperidines | 1990 |
Effect of paroxetine on the electrocardiogram.
Topics: Adult; Calcium; Electrocardiography; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Paroxetine; Piperidines; Posture; Potassium | 1989 |
A placebo-controlled, double-blind, clinical trial of paroxetine in depressed outpatients.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists | 1989 |
The effect of paroxetine on the electroencephalogram, electrocardiogram, and blood pressure.
Topics: Antidepressive Agents; Arousal; Blood Pressure; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Electrocardiography; Electroencephalography; Heart Rate; Humans; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
Paroxetine in the treatment of depression: a comparison with imipramine and placebo.
Topics: Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Imipramine; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists | 1989 |
The therapeutic efficacy of paroxetine: (a) an open study in patients with major depression not responding to antidepressants; (b) a double-blind comparison with amitriptyline in depressed outpatients.
Topics: Aged; Antidepressive Agents; Clomipramine; Depressive Disorder; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists | 1989 |
A double-blind, multicentre study of paroxetine versus clomipramine in depressed elderly patients.
Topics: Aged; Antidepressive Agents; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists | 1989 |
An interim overview of the safety and tolerability of paroxetine.
Topics: Antidepressive Agents; Clinical Trials as Topic; Humans; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
Meta-analysis of early phase II studies with paroxetine in hospitalized depressed patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drug Evaluation; Female; Hospitals, Psychiatric; Humans; Male; Meta-Analysis as Topic; Middle Aged; Paroxetine; Piperidines; Randomized Controlled Trials as Topic; Serotonin Antagonists | 1989 |
A double-blind, multicentre study of paroxetine and mianserin in depression.
Topics: Antidepressive Agents; Bipolar Disorder; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Mianserin; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Serotonin Antagonists | 1989 |
A double-blind study to compare the effectiveness and tolerability of paroxetine and amitriptyline in depressed patients.
Topics: Adult; Amitriptyline; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists | 1989 |
A double-blind comparison of paroxetine and placebo in the treatment of depressed patients in a psychiatric outpatient clinic.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists | 1989 |
A double-blind study of the comparative antidepressant effect of paroxetine and amitriptyline.
Topics: Amitriptyline; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Humans; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists | 1989 |
Platelet 5-HT transport in depressed patients under double-blind treatment with paroxetine versus amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Platelets; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Paroxetine; Piperidines; Randomized Controlled Trials as Topic; Serotonin; Serotonin Antagonists | 1989 |
The effects of paroxetine and maprotiline on mood, perceptual-motor skills, and eye movements in healthy volunteers.
Topics: Adult; Affect; Anthracenes; Antidepressive Agents; Clinical Trials as Topic; Double-Blind Method; Eye Movements; Female; Humans; Male; Maprotiline; Paroxetine; Piperidines; Psychomotor Performance; Serotonin Antagonists | 1989 |
Cardiovascular and psychomotor effects of repeated doses of paroxetine: a comparison with amitriptyline and placebo in healthy men.
Topics: Adult; Amitriptyline; Antidepressive Agents; Arousal; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Heart Conduction System; Heart Rate; Humans; Male; Paroxetine; Piperidines; Psychomotor Performance; Randomized Controlled Trials as Topic; Serotonin Antagonists | 1989 |
The effects of paroxetine and other antidepressants in combination with alcohol on psychomotor activity related to car driving.
Topics: Adult; Alcohol Drinking; Antidepressive Agents; Arousal; Automobile Driving; Ethanol; Female; Humans; Paroxetine; Piperidines; Psychomotor Performance; Randomized Controlled Trials as Topic; Reaction Time; Serotonin Antagonists | 1989 |
The clinical pharmacology of paroxetine in healthy subjects.
Topics: Administration, Oral; Adult; Antidepressive Agents; Arousal; Clinical Trials as Topic; Double-Blind Method; Humans; Male; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists | 1989 |
Paroxetine: lack of effect on the tyramine pressor response in man.
Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents; Arousal; Blood Pressure; Double-Blind Method; Humans; Male; Norepinephrine; Paroxetine; Piperidines; Randomized Controlled Trials as Topic; Serotonin Antagonists; Tyramine | 1989 |
The effect of paroxetine on the quantitative EEG.
Topics: Adult; Amitriptyline; Antidepressive Agents; Arousal; Cerebral Cortex; Clinical Trials as Topic; Electroencephalography; Evoked Potentials; Female; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
The psychomotor effects of paroxetine alone and in combination with haloperidol, amylobarbitone, oxazepam, or alcohol.
Topics: Adult; Amobarbital; Antidepressive Agents; Arousal; Double-Blind Method; Ethanol; Female; Haloperidol; Humans; Male; Middle Aged; Oxazepam; Paroxetine; Piperidines; Psychomotor Performance; Randomized Controlled Trials as Topic; Reaction Time; Serotonin Antagonists | 1989 |
Paroxetine: pharmacokinetic and antidepressant effect in the elderly.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Serotonin Antagonists | 1989 |
A pharmacokinetic dose titration study in adult and elderly depressed patients.
Topics: Adult; Aged; Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serotonin Antagonists | 1989 |
The pharmacokinetics of paroxetine in elderly depressed patients.
Topics: Aged; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
The pharmacokinetics of paroxetine in renal impairment.
Topics: Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Female; Humans; Kidney Failure, Chronic; Kidney Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
The effect of liver enzyme inhibition by cimetidine and enzyme induction by phenobarbitone on the pharmacokinetics of paroxetine.
Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Clinical Trials as Topic; Enzyme Induction; Enzymes; Half-Life; Humans; Male; Microsomes, Liver; Paroxetine; Phenobarbital; Piperidines; Serotonin Antagonists | 1989 |
Absorption of paroxetine under various dietary conditions and following antacid intake.
Topics: Administration, Oral; Adult; Aluminum Hydroxide; Animals; Antidepressive Agents; Clinical Trials as Topic; Dietary Fats; Feeding Behavior; Humans; Intestinal Absorption; Male; Milk; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
The short- and long-term efficacy of paroxetine HCl: A. Data from a 6-week double-blind parallel design trial vs. imipramine and placebo.
Topics: Antidepressive Agents; Depressive Disorder; Double-Blind Method; Humans; Imipramine; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic | 1989 |
The short- and long-term efficacy of paroxetine HCl: B. Data from a double-blind crossover study and from a year-long term trial vs. imipramine and placebo.
Topics: Antidepressive Agents; Depressive Disorder; Double-Blind Method; Humans; Imipramine; Paroxetine; Piperidines; Randomized Controlled Trials as Topic | 1989 |
The predictive value of the dexamethasone suppression test. A placebo-controlled study.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Dexamethasone; Double-Blind Method; Female; Humans; Hydrocortisone; Imipramine; Male; Middle Aged; Paroxetine; Piperidines; Placebos; Predictive Value of Tests; Psychiatric Status Rating Scales | 1989 |
Effects of paroxetine on human sleep.
Topics: Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Sleep; Sleep, REM | 1986 |
Paroxetine in the treatment of depression. A double-blind multicenter study versus mianserin.
Topics: Adult; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Mianserin; Paroxetine; Piperidines; Psychiatric Status Rating Scales | 1988 |
Paroxetine in the treatment of depression--a randomized comparison with amitriptyline.
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Random Allocation; Serotonin Antagonists | 1985 |
Double-blind comparative study of paroxetine and amitriptyline in depressed patients of a university psychiatric outpatient clinic (pilot study).
Topics: Adolescent; Adult; Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales | 1985 |
EEG and blood level of the potential antidepressant paroxetine after a single oral dose to normal volunteers.
Topics: Adult; Antidepressive Agents; Electroencephalography; Humans; Kinetics; Male; Paroxetine; Piperidines | 1984 |
Serotonin uptake inhibition by the monoamine oxidase inhibitor brofaromine.
Topics: Adult; Depressive Disorder; Homovanillic Acid; Humans; Male; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Placebos; Selective Serotonin Reuptake Inhibitors | 1993 |
An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Drug Resistance; Excitatory Amino Acid Antagonists; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Receptors, N-Methyl-D-Aspartate; Research Design; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Time Factors; Treatment Failure; Young Adult | 2008 |
A randomized, controlled study comparing the effects of vestipitant or vestipitant and paroxetine combination in subjects with tinnitus.
Topics: Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Fluorobenzenes; Humans; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Tinnitus; Treatment Outcome | 2011 |
Results from 2 randomized, double-blind, placebo-controlled studies of the novel NK1 receptor antagonist casopitant in patients with major depressive disorder.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Paroxetine; Piperazines; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome | 2011 |
A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dibenzothiazepines; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Electrocardiography; Enzyme Inhibitors; Female; Genotype; Heart Rate; Humans; Isoxazoles; Ketoconazole; Linear Models; Long QT Syndrome; Male; Middle Aged; Paroxetine; Pharmacogenetics; Phenotype; Piperazines; Piperidines; Quetiapine Fumarate; Thiazoles; United States; Young Adult | 2013 |
207 other study(ies) available for paroxetine and piperidines
| Article | Year |
|---|---|
Lithium treatment regimens induce different changes in [3H]paroxetine binding protein and other rat brain proteins.
Topics: Animals; Brain Chemistry; Immunochemistry; Lithium; Male; Nerve Tissue Proteins; Paroxetine; Piperidines; Protein Binding; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1992 |
[3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment.
Topics: Animals; Brain; Fenclonine; Hydroxyindoleacetic Acid; Male; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tissue Distribution; Tritium | 1992 |
Regional studies of serotonin and dopamine metabolism and quantification of serotonin uptake sites in human cerebral cortex.
Topics: Adolescent; Adult; Cerebral Cortex; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; In Vitro Techniques; Kinetics; Male; Membranes; Middle Aged; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sex Characteristics | 1992 |
Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dopamine; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Norepinephrine; Paroxetine; Piperidines; Saimiri; Serotonin; Serotonin Antagonists | 1992 |
Neurochemical changes in the rat brain after intraventricular administration of tryptamine-4,5-dione.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Electrochemistry; Hydroxyindoleacetic Acid; In Vitro Techniques; Indolequinones; Injections, Intraventricular; Male; Membranes; Neurotransmitter Agents; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tryptamines; Tryptophan Hydroxylase | 1992 |
Regional distribution to recovery of 5-HT levels after administration of "atrophins" MDMA and D,L-fenfluramine. Stereospecificity and comparison with 5,7-dihydroxytryptamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; 5,7-Dihydroxytryptamine; Animals; Atrophy; Brain; Cerebral Ventricles; Designer Drugs; Dopamine; Fenfluramine; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Intraventricular; Male; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine; Organ Specificity; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism | 1992 |
Age stability of human brain 5-HT terminals studied with [3H]paroxetine binding.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Binding Sites; Biological Transport, Active; Brain; Child; Child, Preschool; Female; Humans; In Vitro Techniques; Infant; Infant, Newborn; Kinetics; Male; Middle Aged; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists; Sex Characteristics | 1992 |
[123/125I]RTI-55, an in vivo label for the serotonin transporter.
Topics: Animals; Biological Transport, Active; Cocaine; Fenfluramine; Histocytochemistry; Indicators and Reagents; Iodine Radioisotopes; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tomography, Emission-Computed, Single-Photon | 1992 |
Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine.
Topics: Animals; Biological Transport, Active; Blood Platelets; Clomipramine; Endothelium, Vascular; Fluoxetine; Lung; Male; Paroxetine; Piperidines; Plasma; Rats; Rats, Inbred Strains; Serotonin | 1992 |
Presynaptic serotonin mechanisms in rats subjected to inescapable shock.
Topics: Analysis of Variance; Animals; Biological Transport; Brain; Electroshock; Escape Reaction; Helplessness, Learned; Hippocampus; Hypothalamus; In Vitro Techniques; Male; Models, Psychological; Paroxetine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stress, Psychological; Synapses | 1992 |
The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes.
Topics: Antidepressive Agents; Carbon Radioisotopes; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Formates; Humans; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Paroxetine; Piperidines; Serotonin Antagonists | 1992 |
Uptake and release of serotonin in rat cerebrovascular nerves after subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Electric Stimulation; Ischemic Attack, Transient; Ketanserin; Male; Oxidopamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Subarachnoid Hemorrhage; Sympathetic Nervous System; Tetrodotoxin; Vasoconstriction | 1992 |
A clinical profile of paroxetine: a novel selective serotonin reuptake inhibitor (SSRI).
Topics: Antidepressive Agents; Humans; Paroxetine; Piperidines; Serotonin Antagonists | 1992 |
The relationship between paroxetine and the sparteine oxidation polymorphism.
Topics: Adult; Humans; Oxidation-Reduction; Paroxetine; Phenotype; Piperidines; Polymorphism, Genetic; Serotonin Antagonists; Sparteine | 1992 |
Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: nonlinearity and relation to the sparteine oxidation polymorphism.
Topics: Adult; Aged; Diabetic Neuropathies; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Paroxetine; Phenotype; Piperidines; Polymorphism, Genetic; Serotonin Antagonists; Sparteine | 1992 |
Novel selective serotonin reuptake inhibitors, Part I.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Humans; Incidence; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Seizures; Serotonin; Suicide | 1992 |
Serotonergic aspects of the response of human platelets to immune-adjuvant muramyl dipeptide.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adenosine Diphosphate; Adjuvants, Immunologic; Blood Platelets; Carrier Proteins; Humans; Imipramine; Ketanserin; Lysergic Acid Diethylamide; Paroxetine; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1992 |
Effects of the 5-HT uptake inhibitors, femoxetine and paroxetine, and a 5-HT1A/B agonist, eltoprazine, on the behavioural satiety sequence.
Topics: Animals; Behavior, Animal; Male; Paroxetine; Piperazines; Piperidines; Rats; Receptors, Serotonin; Satiety Response; Serotonin Antagonists | 1992 |
One-step purification of the serotonin transporter located at the human platelet plasma membrane.
Topics: Biological Transport; Blood Platelets; Blood Proteins; Carrier Proteins; Cell Membrane; Chromatography, Affinity; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Humans; Ouabain; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Tetrabenazine | 1992 |
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycemic Agents; Maternal-Fetal Exchange; Neurons; Pain; Paroxetine; Piperazines; Piperidines; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spinal Cord; Tetrahydronaphthalenes; Tropanes | 1992 |
Prenatal cocaine exposure disrupts the development of the serotonergic system.
Topics: Animals; Animals, Newborn; Cocaine; Embryonic and Fetal Development; Female; Immunohistochemistry; Maternal-Fetal Exchange; Nerve Fibers; Neurons; Paroxetine; Piperidines; Pregnancy; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists | 1992 |
Chloroamphetamine did not prevent the effects of chronic antidepressants on 5-hydroxytryptamine inhibition of forskolin-stimulated adenylate cyclase in rat hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Antidepressive Agents; Binding Sites; Cerebral Cortex; Chlorides; Colforsin; Hippocampus; Imipramine; Lithium; Lithium Chloride; Male; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Serotonin; Synapses; Tetrahydronaphthalenes | 1991 |
Synthesis and 5-HT receptors binding studies of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines.
Topics: Animals; Binding, Competitive; In Vitro Techniques; Ligands; Male; Paroxetine; Piperazines; Piperidines; Quinolones; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists | 1991 |
Methylenedioxymethamphetamine induces spontaneous tail-flicks in the rat via 5-HT1A receptors.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Reflex; Serotonin; Serotonin Antagonists; Tail | 1991 |
Effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: autoradiographic and functional studies.
Topics: Adrenergic beta-Antagonists; Amitriptyline; Animals; Autoradiography; Brain Chemistry; Cyclic AMP; Desipramine; Iodine Radioisotopes; Iodocyanopindolol; Kinetics; Male; Membranes; Paroxetine; Pindolol; Piperidines; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin Antagonists | 1991 |
Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4-methylenedioxymethamphetamine): assessment using quantitative autoradiography.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Autoradiography; Brain; Dopamine; Male; Mazindol; N-Methyl-3,4-methylenedioxyamphetamine; Neural Pathways; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Time Factors | 1991 |
Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ("Ecstasy").
Topics: 3,4-Methylenedioxyamphetamine; Animals; Autoradiography; Brain Chemistry; Cerebral Cortex; Deoxyglucose; Glucose; Hippocampus; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1991 |
Reduction of in vivo binding of [3H]paroxetine in mouse brain by 3,4-methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hydroxyindoleacetic Acid; Injections, Intravenous; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists | 1990 |
Towards physiologically based treatment of patients with neuropathic pain.
Topics: Analgesics; Animals; Clinical Trials as Topic; Humans; Nervous System Diseases; Pain; Pain Measurement; Palliative Care; Paroxetine; Piperidines | 1990 |
Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Blood Platelets; Frontal Lobe; Hydroxyindoleacetic Acid; Ketanserin; Kinetics; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Time Factors; Tritium | 1991 |
Autoradiographic visualization of NK-3 tachykinin binding sites in the rat brain, utilizing [3H]senktide.
Topics: 5,7-Dihydroxytryptamine; Animals; Autoradiography; Brain; Kinetics; Male; Organ Specificity; Paroxetine; Peptide Fragments; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Reference Values; Serotonin Antagonists; Substance P; Tachykinins; Tritium | 1990 |
[3H]paroxetine binding and serotonin content of rat and rabbit cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region.
Topics: 5-Hydroxytryptophan; Animals; Binding Sites; Brain; Carrier Proteins; Cerebral Cortex; Corpus Striatum; Hippocampus; Hydroxyindoleacetic Acid; Kinetics; Male; Organ Specificity; Paroxetine; Piperidines; Rabbits; Radioligand Assay; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tegmentum Mesencephali; Tritium | 1991 |
Radiosynthesis and evaluation of N-(3-[18F]fluoropropyl)paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by PET.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Fluorine Radioisotopes; Magnetic Resonance Spectroscopy; Male; Mice; Paroxetine; Piperidines; Serotonin; Tomography, Emission-Computed | 1991 |
[3H]citalopram binding to brain and platelet membranes of human and rat.
Topics: Animals; Binding Sites; Blood Platelets; Brain; Carrier Proteins; Cell Membrane; Citalopram; Humans; Imipramine; Kinetics; Neurons; Paroxetine; Piperidines; Rats; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Temperature; Thermodynamics | 1991 |
Isothiocyanate derivatives of cocaine: irreversible inhibition of ligand binding at the dopamine transporter.
Topics: Animals; Benzamides; Binding, Competitive; Brain Stem; Carrier Proteins; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Ligands; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Thiocyanates | 1991 |
Modulation of [3H]paroxetine binding to the 5-hydroxytryptamine uptake site in an animal model of depression.
Topics: Animals; Binding Sites; Depression; Male; Paroxetine; Piperidines; Rats; Receptors, Serotonin; Reference Values; Serotonin Antagonists; Tritium | 1991 |
Effects of acute paroxetine administration on tryptophan metabolism and disposition in the rat.
Topics: Administration, Oral; Animals; Antidepressive Agents; Brain; Corticosterone; Enzyme Induction; Hydrocortisone; In Vitro Techniques; Liver; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1991 |
5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine.
Topics: Amphetamines; Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Electrochemistry; Indans; Iodine Radioisotopes; Male; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains | 1991 |
Ethanol intake and 3H-serotonin uptake. II: A study in alcoholic patients using platelets 3H-paroxetine binding.
Topics: Adult; Alcoholism; Blood Platelets; Humans; Kinetics; Middle Aged; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists | 1991 |
Characterization and purification of the neuronal sodium-ion-coupled 5-hydroxytryptamine transporter.
Topics: Animals; Binding, Competitive; Biological Transport, Active; Carrier Proteins; Cell Membrane; Cerebral Cortex; Kinetics; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Sodium | 1991 |
3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Dopamine; In Vitro Techniques; Male; Molecular Structure; Nervous System; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Synaptosomes; Tritium | 1991 |
Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding.
Topics: Animals; Binding, Competitive; Cell Line; Cerebral Cortex; Imidazoles; Indoles; Kinetics; Ligands; Mice; Nervous System Neoplasms; Neuroblastoma; Paroxetine; Piperidines; Quipazine; Rats; Receptors, Serotonin; Serotonin Antagonists; Tumor Cells, Cultured | 1991 |
Affinity modulation of [3H]imipramine, [3H]paroxetine and [3H]citalopram binding to the 5-HT transporter from brain and platelets.
Topics: Animals; Blood Platelets; Brain; Carrier Proteins; Cell Membrane; Citalopram; Half-Life; Humans; Imipramine; In Vitro Techniques; Membrane Proteins; Paroxetine; Piperidines; Rats; Serotonin Plasma Membrane Transport Proteins | 1991 |
No crossover reactions to citalopram or paroxetine among patients hypersensitive to zimeldine.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Citalopram; Combined Modality Therapy; Depressive Disorder; Drug Hypersensitivity; Female; Follow-Up Studies; Humans; Liver Function Tests; Male; Paroxetine; Piperidines; Serotonin Antagonists; Zimeldine | 1991 |
Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats.
Topics: Animals; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; Isoquinolines; Male; Monoamine Oxidase; Muscle Contraction; Muscle, Smooth, Vascular; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Stereoisomerism | 1991 |
Evidence for high and low affinity [3H]cocaine binding sites associated with the serotonin reuptake complex in guinea pig brain: allosteric modulation by paroxetine.
Topics: Animals; Brain Chemistry; Carrier Proteins; Guinea Pigs; In Vitro Techniques; Kinetics; Membranes; Paroxetine; Piperidines; Receptors, Drug; Serotonin; Stereoisomerism | 1990 |
Evidence for the existence of serotonin uptake inhibitor-like substances in human cerebrospinal fluid.
Topics: Animals; Binding Sites; Brain; Haplorhini; Humans; Imipramine; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists; Synaptosomes | 1991 |
Sertraline (Lustral) and paroxetine (Seroxat)--new drugs for the treatment of depression.
Topics: 1-Naphthylamine; Antidepressive Agents; Depressive Disorder; Humans; Paroxetine; Piperidines; Sertraline | 1991 |
Concentration-response relationship in paroxetine treatment of diabetic neuropathy symptoms: a patient-blinded dose-escalation study.
Topics: Adult; Aged; Diabetic Neuropathies; Dosage Forms; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Pain Measurement; Paroxetine; Piperidines; Serotonin Antagonists | 1991 |
Platelet 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat.
Topics: 5,7-Dihydroxytryptamine; Animals; Brain; Depressive Disorder; Imipramine; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists | 1991 |
3H-paroxetine binding in brains of alcoholics.
Topics: Adult; Aged; Alcoholism; Binding Sites; Cerebral Cortex; Data Interpretation, Statistical; Female; Hippocampus; Humans; Male; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists | 1991 |
Platelet 3H-imipramine and 3H-paroxetine binding during treatment with psychoactive drugs.
Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Female; Humans; Imipramine; Male; Mental Disorders; Middle Aged; Paroxetine; Piperidines; Psychotropic Drugs; Radioligand Assay; Serotonin Antagonists | 1991 |
Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Electric Stimulation; Electrophysiology; Hippocampus; Imipramine; Male; Neurons; Paroxetine; Piperidines; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Synapses; Tetrahydronaphthalenes | 1991 |
Pharmacokinetics of paroxetine in patients with cirrhosis.
Topics: Adult; Aged; Cimetidine; Disulfiram; Drug Interactions; Female; Half-Life; Humans; Liver Cirrhosis, Alcoholic; Liver Function Tests; Male; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists | 1991 |
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Behavior, Animal; Catecholamines; Cerebral Cortex; Hippocampus; Indans; Lysergic Acid Diethylamide; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Psychotropic Drugs; Rats; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1990 |
5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain Chemistry; In Vitro Techniques; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Synaptosomes | 1990 |
Neurochemistry and neurotoxicity of substituted amphetamines.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Designer Drugs; Fenfluramine; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Paroxetine; Piperidines; Rats; Receptors, Serotonin; Serotonin | 1990 |
Laminar distributions of muscarinic acetylcholine, serotonin, GABA and opioid receptors in human posterior cingulate cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Autoradiography; Cerebral Cortex; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Humans; Iodocyanopindolol; Ketanserin; Male; Middle Aged; Oxotremorine; Paroxetine; Pindolol; Piperidines; Pirenzepine; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Opioid; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1990 |
Effect of prolonged 5-hydroxytryptamine uptake inhibition by paroxetine on cortical beta 1 and beta 2-adrenoceptors in rat brain.
Topics: Adrenergic beta-Antagonists; Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Dose-Response Relationship, Drug; Imidazoles; Kinetics; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Propanolamines; Radioligand Assay; Rats; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin | 1990 |
Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomography ligand?
Topics: 3,4-Methylenedioxyamphetamine; 5,7-Dihydroxytryptamine; Animals; Ligands; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Synapses; Tomography, Emission-Computed; Tritium | 1990 |
Antidepressant binding sites in brain: autoradiographic comparison of [3H]paroxetine and [3H]imipramine localization and relationship to serotonin transporter.
Topics: Animals; Antidepressive Agents; Autoradiography; Binding Sites; Brain; Imipramine; In Vitro Techniques; Kinetics; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1990 |
Regional distribution of the serotonin transport complex in human brain, identified with 3H-paroxetine, 3H-citalopram and 3H-imipramine.
Topics: Adolescent; Adult; Aged; Binding, Competitive; Biological Transport; Brain; Citalopram; Female; Humans; Imipramine; Kinetics; Male; Membranes; Middle Aged; Organ Specificity; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1990 |
Serotonergic and catecholaminergic reuptake inhibitors have opposite effects on the ultrasonic isolation calls of rat pups.
Topics: Animals; Body Temperature; Catecholamines; Citalopram; Clomipramine; Desipramine; Flumazenil; Mazindol; Motor Activity; Naltrexone; Nortriptyline; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Stress, Psychological; Ultrasonics; Vocalization, Animal | 1990 |
Cellular localization of serotonin 1A, 1B and uptake sites in cingulate cortex of the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Immunotoxins; Iodocyanopindolol; Male; Paroxetine; Pindolol; Piperidines; Rats; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1990 |
[3H] sertraline binding to rat brain membranes.
Topics: 1-Naphthylamine; Animals; Brain; Fenclonine; Fluoxetine; Imipramine; In Vitro Techniques; Male; Membranes; Naphthalenes; Paroxetine; Piperidines; Rats; Receptors, Serotonin; Serotonin Antagonists; Sertraline | 1990 |
Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine.
Topics: Animals; Biogenic Monoamines; Fenfluramine; Frontal Lobe; Hippocampus; Male; Neurons; Norfenfluramine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism | 1990 |
Effect of serotonergic lesion on "anxious" behaviour measured in the elevated plus-maze test in the rat.
Topics: 5,7-Dihydroxytryptamine; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Injections, Intraventricular; Kinetics; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1990 |
High-affinity paroxetine binding to the human placental serotonin transporter.
Topics: 4-Chloro-7-nitrobenzofurazan; Binding, Competitive; Biological Transport; Carrier Proteins; Female; Humans; Imidazoles; Kinetics; Microvilli; Paroxetine; Piperidines; Placenta; Pregnancy; Serotonin; Serotonin Antagonists; Sodium; Tetranitromethane; Tyrosine | 1990 |
Inhibition of neuronal 5-HT uptake by ketamine, but not halothane, involves disruption of substrate recognition by the transporter.
Topics: Anesthetics; Animals; Brain; Halothane; Ketamine; Male; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Synaptosomes | 1990 |
Effects of high-dose fenfluramine treatment on monoamine uptake sites in rat brain: assessment using quantitative autoradiography.
Topics: Animals; Autoradiography; Biogenic Monoamines; Brain; Fenfluramine; Male; Mazindol; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Tritium | 1990 |
Seasonal variations in binding of 3H-paroxetine to blood platelets in healthy volunteers: indications for a gender difference.
Topics: Adult; Blood Platelets; Carrier Proteins; Female; Humans; Longitudinal Studies; Male; Paroxetine; Piperidines; Reference Values; Seasons; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Sex Factors | 1990 |
Symmetrical hemispheric distribution of 3H-paroxetine binding sites in postmortem human brain from controls and suicides.
Topics: Adult; Brain; Brain Mapping; Depressive Disorder; Dominance, Cerebral; Female; Frontal Lobe; Humans; Male; Middle Aged; Paroxetine; Piperidines; Putamen; Receptors, Serotonin; Retrospective Studies; Serotonin Antagonists; Substantia Nigra; Suicide | 1990 |
Evaluation of 3H-paroxetine as a radioligand for in vivo study of 5-hydroxytryptamine uptake sites in mouse brain.
Topics: Animals; Binding Sites; Brain; Evaluation Studies as Topic; Injections, Intravenous; Male; Mice; Paroxetine; Piperidines; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Tritium | 1990 |
Interaction of fluoxetine with the human placental serotonin transporter.
Topics: Carrier Proteins; Female; Fluoxetine; Humans; In Vitro Techniques; Microvilli; Paroxetine; Piperidines; Placenta; Pregnancy; Serotonin; Serotonin Antagonists | 1990 |
Preparation and characterization of anti-paroxetine antibodies.
Topics: Animals; Antibody Affinity; Antibody Specificity; Cross Reactions; Glutaral; Haptens; Immunoglobulin G; Paroxetine; Piperidines; Rabbits; Radioimmunoassay; Serotonin Antagonists; Serum Albumin, Bovine | 1990 |
Inhibitory and regulatory binding sites on the rat brain serotonin transporter: molecular weight of the [3H]paroxetine and [3H]citalopram binding proteins.
Topics: Animals; Biological Transport, Active; Brain; Carrier Proteins; Citalopram; Half-Life; In Vitro Techniques; Kinetics; Models, Biological; Molecular Weight; Paroxetine; Piperidines; Rats; Receptors, Serotonin | 1990 |
Binding of [3H]dihydrotetrabenazine and [125I]azidoiodoketanserin photoaffinity labeling of the monoamine transporter of platelet 5-HT organelles.
Topics: Affinity Labels; Animals; Azides; Biogenic Monoamines; Blood Platelets; Blood Proteins; Cell Membrane; Guinea Pigs; Humans; In Vitro Techniques; Iodine Radioisotopes; Ketanserin; Paroxetine; Photochemistry; Piperidines; Rabbits; Rats; Receptors, Serotonin; Subcellular Fractions; Tetrabenazine | 1990 |
Prenatal treatment with a selective D1 receptor agonist (SKF 38393) alters adult [3H]paroxetine binding and dopamine and serotonin behavioral sensitivity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Brain Stem; Cerebral Cortex; Conditioning, Operant; Dopamine; Female; Kinetics; Paroxetine; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Serotonin | 1990 |
Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides.
Topics: Brain Chemistry; Depressive Disorder; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Receptors, Serotonin; Retrospective Studies; Serotonin Antagonists; Suicide; Tritium | 1990 |
Inhibition of MAO activity, 3H-imipramine binding, 3H-paroxetine binding and 3H-5-HT uptake by human cerebrospinal fluid.
Topics: Animals; Binding, Competitive; Brain; Cerebral Cortex; Cerebrospinal Fluid; Humans; Imipramine; Kinetics; Macaca mulatta; Membranes; Mitochondria; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Receptors, Drug; Serotonin | 1990 |
Interaction between serotonin uptake inhibitors and alpha-2 adrenergic heteroreceptors in the rat hypothalamus.
Topics: Animals; Brimonidine Tartrate; Citalopram; Fenclonine; Hypothalamus; In Vitro Techniques; Male; Norepinephrine; Paroxetine; Piperidines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1990 |
Why some depressed patients may have low platelet 3H-imipramine binding.
Topics: Antidepressive Agents; Blood Platelets; Carrier Proteins; Cell Membrane; Clomipramine; Depressive Disorder; Humans; Imipramine; Paroxetine; Piperidines; Receptors, Drug; Receptors, Neurotransmitter; Serotonin Antagonists | 1990 |
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Brain Chemistry; Dopamine; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tritium | 1987 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imipramine; Ketanserin; Kinetics; Male; Paroxetine; Piperidines; Prazosin; Proteins; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Time Factors | 1988 |
Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Monoamines; Brain Chemistry; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Postsynaptic localization and up-regulation of serotonin 5-HT1D receptors in rat brain.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1989 |
In vivo labeling of serotonin uptake sites with [3H]paroxetine.
Topics: Affinity Labels; Animals; Brain; Cerebellum; Hypothalamus; Kinetics; Male; Mice; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stereoisomerism; Tissue Distribution; Tritium; Zimeldine | 1989 |
High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue.
Topics: Aged; Aged, 80 and over; Binding, Competitive; Brain; Citalopram; Female; Humans; Kinetics; Male; Middle Aged; Paroxetine; Piperidines; Receptors, Serotonin | 1989 |
Nialamide-induced hypermotility in mice treated with inhibitors of monoamine uptake, 5-HT antagonists and lithium.
Topics: Animals; Diet; Female; Lithium; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Nialamide; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
Production of wet-dog shakes in rats and down-regulation of spinal 5-HT2 receptors.
Topics: Animals; Behavior, Animal; Brain Stem; Ketanserin; Male; Paroxetine; Phenelzine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Spinal Cord | 1989 |
Differences in the temperature dependence of drug interaction with the noradrenaline and serotonin transporters.
Topics: Animals; Biogenic Monoamines; Blood Platelets; Humans; Imipramine; In Vitro Techniques; Male; Mazindol; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Salivary Glands; Serotonin; Serotonin Antagonists; Temperature | 1989 |
Drug inhibition indicates a single-site model of the 5-HT uptake site/antidepressant binding site in rat and human brain.
Topics: Aged; Animals; Antidepressive Agents; Binding Sites; Brain; Citalopram; Clomipramine; Humans; In Vitro Techniques; Male; Middle Aged; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Light-dark differences in [3H]-paroxetine binding to rabbit platelet membranes.
Topics: Animals; Blood Platelets; Cell Membrane; Circadian Rhythm; Darkness; Imipramine; In Vitro Techniques; Light; Male; Paroxetine; Piperidines; Rabbits; Serotonin Antagonists | 1989 |
Synthesis and 5HT-receptors affinity of some 4-phenylquinoline derivatives.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Paroxetine; Piperidines; Quinolines; Quipazine; Rats; Receptors, Serotonin; Serotonin Antagonists; Synapses | 1989 |
[Behavioral pharmacological properties of the novel antidepressant paroxetine, a selective 5-HT uptake inhibitor].
Topics: Aggression; Anesthesia; Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Male; Mice; Motor Activity; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Stereotyped Behavior | 1989 |
[Evaluation of 3H-paroxetine as a radiopharmaceutical for lung function].
Topics: Animals; Lung; Male; Mice; Paroxetine; Piperidines; Radionuclide Imaging; Serotonin Antagonists; Tissue Distribution; Tritium | 1989 |
The antidepressant paroxetine: a specific 5-HT uptake inhibitor. Proceedings of an international symposium. September, 1988.
Topics: Antidepressive Agents; Humans; Paroxetine; Piperidines | 1989 |
Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin.
Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Diazepam; Digoxin; Drug Interactions; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists; Warfarin | 1989 |
Introduction to the development of paroxetine, a novel antidepressant.
Topics: Antidepressive Agents; Depressive Disorder; Humans; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
Antidepressants and the peripheral nervous system.
Topics: Amitriptyline; Antidepressive Agents; Depressive Disorder; Electromyography; Humans; Neural Conduction; Paroxetine; Peripheral Nerves; Piperidines; Serotonin Antagonists | 1989 |
Paroxetine plasma levels: lack of correlation with efficacy or adverse events.
Topics: Antidepressive Agents; Depressive Disorder; Humans; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Retrospective Studies; Serotonin Antagonists | 1989 |
Ability of charcoal to prevent absorption of paroxetine.
Topics: Administration, Oral; Adult; Antidepressive Agents; Charcoal; Dose-Response Relationship, Drug; Humans; Intestinal Absorption; Male; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
Pharmacological effects of paroxetine after repeated administration to animals.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Cerebral Cortex; Male; Paroxetine; Piperidines; Radioligand Assay; Rats; Receptors, Serotonin; Serotonin Antagonists | 1989 |
Metabolic pathway of paroxetine in animals and man and the comparative pharmacological properties of its metabolites.
Topics: Animals; Antidepressive Agents; Biotransformation; Brain; Chemical Phenomena; Chemistry; Humans; Hypothalamus; Mice; Paroxetine; Piperidines; Rats; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Synaptosomes | 1989 |
Relative lack of cardiotoxicity of paroxetine in animal models.
Topics: Amitriptyline; Animals; Antidepressive Agents; Blood Pressure; Cats; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart Conduction System; Heart Rate; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
Comparative acute toxicity of paroxetine and other antidepressants.
Topics: Animals; Antidepressive Agents; Arousal; Dogs; Dose-Response Relationship, Drug; Lethal Dose 50; Macaca mulatta; Mice; Paroxetine; Piperidines; Rats; Serotonin Antagonists | 1989 |
General and genetic toxicology of paroxetine.
Topics: Animals; Antidepressive Agents; Carcinogenicity Tests; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Mice; Mutagenicity Tests; Paroxetine; Piperidines; Rats; Serotonin Antagonists | 1989 |
The reproductive toxicology of paroxetine.
Topics: Abnormalities, Drug-Induced; Animals; Antidepressive Agents; Body Weight; Dose-Response Relationship, Drug; Female; Litter Size; Paroxetine; Piperidines; Pregnancy; Pregnancy, Animal; Rabbits; Rats; Serotonin Antagonists | 1989 |
Immunological evaluation of paroxetine.
Topics: Animals; Antibodies; Antidepressive Agents; Humans; Immunity, Cellular; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
Regional distribution of serotonergic pre- and postsynaptic markers in human brain.
Topics: Antidepressive Agents; Brain; Brain Mapping; Dose-Response Relationship, Drug; Humans; Paroxetine; Piperidines; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Synapses | 1989 |
The pharmacokinetics of paroxetine in the elderly.
Topics: Administration, Oral; Adult; Age Factors; Aged; Antidepressive Agents; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Reference Values; Serotonin Antagonists | 1989 |
The pharmacokinetics of paroxetine in patients with liver cirrhosis.
Topics: Aged; Antidepressive Agents; Female; Humans; Intestinal Absorption; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
Paroxetine: lack of effect on hepatic drug metabolizing enzymes.
Topics: Adult; Animals; Antidepressive Agents; Antipyrine; Cytochrome P-450 Enzyme System; Enzymes; Humans; Inactivation, Metabolic; Microsomes, Liver; Paroxetine; Piperidines; Rats; Serotonin Antagonists | 1989 |
A common binding site for tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors at the substrate recognition site of the neuronal sodium-dependent 5-hydroxytryptamine transporter.
Topics: Animals; Antidepressive Agents, Tricyclic; Binding Sites; Binding, Competitive; Biological Transport; Cerebral Cortex; Citalopram; Dose-Response Relationship, Drug; Ethylmaleimide; Fluoxetine; Imipramine; Male; Neurons; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sodium | 1989 |
Brain 5-HT uptake sites, labelled with [3H]-paroxetine, in post-mortem samples from depressed suicide victims.
Topics: Adult; Brain; Depressive Disorder; Female; Humans; In Vitro Techniques; Male; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin Antagonists; Suicide | 1989 |
'[3H]quipazine' degradation products label 5-HT uptake sites.
Topics: Animals; Chromatography, High Pressure Liquid; In Vitro Techniques; Paroxetine; Piperidines; Quinolines; Quipazine; Radioligand Assay; Rats; Receptors, Serotonin | 1989 |
Inhibition and dissociation of [3H]-paroxetine binding to human platelets.
Topics: Antidepressive Agents; Binding, Competitive; Blood Platelets; Dose-Response Relationship, Drug; Humans; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1989 |
Effect of 5-hydroxytryptamine on [3H]-acetylcholine release from guinea-pig striatal slices.
Topics: Acetylcholine; Animals; Caudate Nucleus; Corpus Striatum; Dopamine; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Neurotransmitter Agents; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists | 1989 |
Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Cerebral Cortex; Corpus Striatum; Designer Drugs; Dopamine; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Nervous System Diseases; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Reserpine; Serotonin | 1989 |
Repeated electroconvulsive shock does not change [3H]-paroxetine binding to the 5-HT uptake site in rat cortical membranes.
Topics: Animals; Cerebral Cortex; Electroshock; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin Antagonists; Tritium | 1988 |
Interaction between tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors and the presynaptic 5-hydroxytryptamine inhibitory autoreceptors in the rat hypothalamus.
Topics: 5-Methoxytryptamine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Citalopram; Electric Stimulation; Fenclonine; Hypothalamus; Imipramine; Lysergic Acid Diethylamide; Male; Methiothepin; Neurotransmitter Agents; Pargyline; Paroxetine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin | 1985 |
Reduced high-affinity glutamate uptake sites in the brains of patients with Huntington's disease.
Topics: Aged; Aspartic Acid; Brain; Caudate Nucleus; Female; Frontal Lobe; Glutamates; Glutamic Acid; Hippocampus; Humans; Huntington Disease; Male; Middle Aged; Paroxetine; Piperidines; Putamen | 1986 |
The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants.
Topics: Animals; Blood Platelets; Humans; Imipramine; In Vitro Techniques; Neurons; Paroxetine; Piperidines; Rats; Serotonin; Structure-Activity Relationship; Synaptosomes | 1987 |
Paroxetine, a selective 5-hydroxytryptamine uptake inhibitor with antidepressant properties, lacks amphetamine-like stimulus properties in an operant drug discrimination bioassay in rodents.
Topics: Animals; Antidepressive Agents; Conditioning, Operant; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Female; Flicker Fusion; Nomifensine; Paroxetine; Piperidines; Psychomotor Performance; Rats; Serotonin Antagonists; Tranylcypromine | 1988 |
Characterization of [3H]paroxetine binding to rat cortical membranes.
Topics: Animals; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; Membranes; Nerve Endings; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1985 |
Effects of antidepressant drug combinations on cortical 5-HT2 receptors and wet-dog shakes in rats.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Carbidopa; Cerebral Cortex; Citalopram; Drug Interactions; Fenfluramine; Male; Methoxydimethyltryptamines; Paroxetine; Phenelzine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reflex; Serotonin; Time Factors | 1985 |
Antidepressive drugs can change the affinity of [3H]imipramine and [3H]paroxetine binding to platelet and neuronal membranes.
Topics: Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Blood Platelets; Brain; Cell Membrane; Citalopram; Imipramine; In Vitro Techniques; Kinetics; Paroxetine; Piperidines; Propylamines; Rats; Serotonin; Serotonin Antagonists; Synaptic Membranes | 1985 |
Parkinson's disease: decreased density of 3H-imipramine and 3H-paroxetine binding sites in putamen.
Topics: Aged; Binding Sites; Humans; Imipramine; Middle Aged; Parkinson Disease; Paroxetine; Piperidines; Putamen; Tritium | 1986 |
The stereoselectivity of serotonin uptake in brain tissue and blood platelets: the topography of the serotonin uptake area.
Topics: Alanine; Amphetamine; Aniline Compounds; Animals; Antidepressive Agents; Blood Platelets; Brain; Fluoxetine; Humans; Male; Methadone; Mianserin; Mirtazapine; Morpholines; Naphthalenes; Nefopam; Nomifensine; Paroxetine; Piperidines; Rabbits; Serotonin; Stereoisomerism; Tranylcypromine; Viloxazine; Zimeldine | 1986 |
Comparison of some effects of paroxetine with amitriptyline on the cardiovascular system in animals.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cats; Drug Evaluation, Preclinical; Electrocardiography; Female; Heart Conduction System; Hypotension; Infusions, Parenteral; Male; Myocardial Contraction; Paroxetine; Piperidines; Rabbits; Seizures; Serotonin Antagonists; Tachycardia | 1986 |
Solubilization and characterization of the 5-hydroxytryptamine transporter complex from rat cerebral cortical membranes.
Topics: Animals; Biological Transport; Cerebral Cortex; Chromatography, Gel; Kinetics; Male; Membranes; Paroxetine; Piperidines; Rats; Serotonin | 1986 |
High affinity binding of 3H-paroxetine and 3H-imipramine to rat neuronal membranes.
Topics: Animals; Binding Sites; Blood Platelets; Brain; Female; Imipramine; In Vitro Techniques; Membranes; Paroxetine; Piperidines; Rats; Rats, Inbred Strains | 1986 |
High- and low-affinity binding of [3H]imipramine in rat hypothalamus.
Topics: Amitriptyline; Animals; Citalopram; Clomipramine; Cyclopropanes; Hypothalamus; Imipramine; Kinetics; Male; Milnacipran; Paroxetine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Serotonin; Sodium | 1986 |
Temperature dependence of drug interaction with the platelet 5-hydroxytryptamine transporter: a clue to the imipramine selectivity paradox.
Topics: Biological Transport, Active; Blood Platelets; Humans; Imipramine; Kinetics; Paroxetine; Piperidines; Receptors, Serotonin; Temperature | 1987 |
Chlorimipramine--but not imipramine--rapidly reduces imipramine--but not paroxetine--binding in human platelets.
Topics: Blood Platelets; Clomipramine; Humans; Imipramine; Iodine; Paroxetine; Piperidines; Serotonin; Tritium | 1986 |
Effect of chronic treatment with selective monoamine oxidase inhibitors and specific 5-hydroxytryptamine uptake inhibitors on [3H]paroxetine binding to cerebral cortical membranes of the rat.
Topics: Animals; Cerebral Cortex; Citalopram; Clomipramine; Clorgyline; Kinetics; Male; Membranes; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Selegiline; Serotonin | 1987 |
Determination of paroxetine in human plasma, using high-performance liquid chromatography with fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Humans; Indicators and Reagents; Paroxetine; Piperidines; Serotonin Antagonists; Spectrometry, Fluorescence | 1987 |
Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor.
Topics: Animals; Antidepressive Agents; Biological Transport, Active; Brain; In Vitro Techniques; Kinetics; Male; Norepinephrine; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Serotonin; Serotonin Antagonists; Synaptosomes | 1987 |
In vivo voltammetric study of cortical 5-HT after administration of 5-HTP or paroxetine to phenelzine-treated rats.
Topics: 5-Hydroxytryptophan; Animals; Cerebral Cortex; Male; Microelectrodes; Paroxetine; Phenelzine; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Cardiovascular effects of paroxetine, a newly developed antidepressant, in anesthetized dogs in comparison with those of imipramine, amitriptyline and clomipramine.
Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents; Atrioventricular Node; Blood Pressure; Clomipramine; Dogs; Electrocardiography; Female; Heart Conduction System; Heart Rate; Hemodynamics; Imipramine; Male; Paroxetine; Piperidines; Respiration | 1987 |
Effects of the selective 5-hydroxytryptamine uptake inhibitors paroxetine and zimeldine on EEG sleep and waking stages in the rat.
Topics: Administration, Oral; Animals; Brain; Electroencephalography; Female; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Sleep; Sleep Stages; Wakefulness; Zimeldine | 1987 |
Characterization of [3H]paroxetine binding in rat brain.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cerebral Cortex; Citalopram; Fluoxetine; Imipramine; Male; Paroxetine; Peptide Hydrolases; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tritium | 1988 |
Electroencephalographic effects of the new antidepressant paroxetine in the rabbit.
Topics: Amitriptyline; Animals; Antidepressive Agents; Arousal; Drug Interactions; Electric Stimulation; Electroencephalography; Limbic System; Male; Paroxetine; Photic Stimulation; Physostigmine; Piperidines; Rabbits; Recruitment, Neurophysiological | 1988 |
Regional and subcellular localization in human brain of [3H]paroxetine binding, a marker of serotonin uptake sites.
Topics: Adult; Aged; Animals; Binding, Competitive; Brain; Brain Mapping; Cerebral Cortex; Corpus Striatum; Humans; Ketanserin; Male; Middle Aged; Paroxetine; Piperidines; Putamen; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Subcellular Fractions; Synaptosomes | 1988 |
Immunological studies on paroxetine, a novel anti-depressant drug.
Topics: Adult; Aged; Animals; Antibody Formation; Antidepressive Agents; Female; Guinea Pigs; Humans; Immunity; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Middle Aged; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists | 1988 |
Dissociation kinetics of [3H]paroxetine binding to rat brain consistent with a single-site model of the antidepressant binding/5-hydroxytryptamine uptake site.
Topics: Animals; Brain; Cell Membrane; Citalopram; Clomipramine; Imipramine; Kinetics; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Zimeldine | 1988 |
Changes in cortical 5-HT2 receptors following 5-HTP and paroxetine administration in rats.
Topics: Animals; Carbidopa; Cerebral Cortex; Ketanserin; Male; Paroxetine; Phenelzine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin | 1988 |
Autoradiographic localization of 3H-paroxetine-labeled serotonin uptake sites in rat brain.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cerebral Cortex; Kinetics; Male; Organ Specificity; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Synaptosomes; Tritium | 1987 |
Autoradiography of antidepressant binding sites in the human brain: localization using [3H]imipramine and [3H]paroxetine.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Autoradiography; Brain; Child; Female; Humans; Imipramine; Male; Middle Aged; Paroxetine; Piperidines; Receptors, Serotonin; Spinal Cord | 1988 |
[Characteristics of 3H-paroxetine-labeled serotonin uptake sites in rat brain].
Topics: Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Brain; In Vitro Techniques; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Tritium | 1988 |
Measuring the serotonin uptake site using [3H]paroxetine--a new serotonin uptake inhibitor.
Topics: Animals; Cerebral Cortex; Electroconvulsive Therapy; Imipramine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Obese; Paroxetine; Piperidines; Receptors, Serotonin; Tritium | 1988 |
Platelet 3H-paroxetine binding in depressed patients.
Topics: Adult; Antidepressive Agents; Blood Platelets; Depressive Disorder; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychological Tests; Serotonin | 1988 |
First results of an open phase II study with the antidepressant paroxetine.
Topics: Adult; Aged; Antidepressive Agents; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Psychiatric Status Rating Scales | 1988 |
Specific binding sites for cyclic antidepressants.
Topics: Animals; Binding Sites; Carrier Proteins; Humans; Imipramine; Paroxetine; Piperidines; Receptors, Drug; Receptors, Neurotransmitter; Serotonin; Temperature | 1985 |
p,p'-DDT-induced myoclonus in mice: the effect of enhanced 5-HT neurotransmission.
Topics: 5-Hydroxytryptophan; Animals; Carbidopa; DDT; Female; Mice; Mice, Inbred Strains; Myoclonus; Paroxetine; Piperidines; Serotonin; Synaptic Transmission; Tryptophan | 1985 |
Pitfalls in demonstrating an endogenous ligand of imipramine recognition sites.
Topics: Animals; Binding Sites; Brain Chemistry; Chromatography, High Pressure Liquid; Imipramine; Ligands; Osmolar Concentration; Paroxetine; Piperidines; Rats; Receptors, Cell Surface; Serotonin; Serotonin Antagonists | 1987 |
[Specific inhibitory action of a novel antidepressant paroxetine on 5-HT uptake].
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain; Dopamine; Guinea Pigs; In Vitro Techniques; Male; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin | 1987 |
Association of [3H]-imipramine and [3H]-paroxetine binding with the 5HT transporter in brain and platelets: relevance to studies in depression.
Topics: Animals; Antidepressive Agents; Blood Platelets; Brain Chemistry; Carrier Proteins; Depressive Disorder; Female; Humans; Imipramine; Male; Paroxetine; Piperidines; Rabbits; Rats; Receptors, Drug; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin | 1987 |
A comparison of the effect of paroxetine and amitriptyline on the tyramine pressor response test.
Topics: Adult; Amitriptyline; Blood Pressure; Humans; Hypnotics and Sedatives; Male; Paroxetine; Piperidines; Serotonin Antagonists; Tyramine | 1985 |
Is waning of a 5-hydroxytryptamine (5-HT)-mediated syndrome due to 5-HT2 receptor down-regulation?
Topics: Animals; Cerebral Cortex; Ketanserin; Male; Myoclonus; Paroxetine; Phenelzine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Syndrome; Time Factors; Tritium | 1985 |
Size determination of binding polymers for [3H]imipramine and [3H]paroxetine in human platelet membranes.
Topics: Blood Platelets; Carrier Proteins; Cell Membrane; Electrons; Humans; Imipramine; In Vitro Techniques; Membrane Proteins; Molecular Weight; Paroxetine; Piperidines; Protein Binding; Receptors, Drug; Receptors, Neurotransmitter; Serotonin Antagonists | 1984 |
Treatment of myoclonic syndromes with paroxetine alone or combined with 5-HTP.
Topics: 5-Hydroxytryptophan; Adult; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myoclonus; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists; Syndrome | 1982 |
Paroxetine: pharmacokinetics and cardiovascular effects after oral and intravenous single doses in man.
Topics: Administration, Oral; Adult; Biological Availability; Half-Life; Hemodynamics; Humans; Injections, Intravenous; Kinetics; Male; Paroxetine; Piperidines | 1982 |
An early clinical phase II evaluation of paroxetine, a new potent and selective 5HT-uptake inhibitor in patients with depressive illness.
Topics: Adult; Aged; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Serotonin | 1982 |
Effects of bretylium and guanethidine on 3H-noradrenaline and 3H-serotonin release in rat brain cortex slices.
Topics: Animals; Bretylium Compounds; Cerebral Cortex; Electric Stimulation; Guanethidine; In Vitro Techniques; Male; Neurons; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1983 |
Imipramine binding site. Temperature dependence of the binding of 3H-labeled imipramine and 3H-labeled paroxetine to human platelet membrane.
Topics: Binding Sites; Blood Platelets; Cell Membrane; Humans; Imipramine; Kinetics; Mathematics; Paroxetine; Piperidines; Temperature | 1984 |
High affinity binding of [3H]paroxetine and [3H]imipramine to human platelet membranes.
Topics: Antidepressive Agents, Tricyclic; Blood Platelets; Cell Membrane; Humans; Imipramine; Kinetics; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin Antagonists | 1983 |
Acute or chronic changes of noradrenergic transmission do not affect the alpha-adrenoceptor-mediated inhibition of 3H-serotonin release in the cerebral cortex.
Topics: Animals; Cerebral Cortex; Desipramine; Drug Interactions; Guanethidine; Hydroxydopamines; Male; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission | 1982 |
Central and peripheral 5-HT uptake in rats treated chronically with femoxetine, paroxetine, and chlorimipramine.
Topics: Animals; Anisoles; Brain; Clomipramine; Diet; Dioxolanes; Female; Male; Motor Activity; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Serotonin; Serotonin Antagonists | 1980 |
Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors.
Topics: 1-Naphthylamine; 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Analysis of Variance; Animals; Behavior, Animal; Brain; Citalopram; Dose-Response Relationship, Drug; Fenclonine; Fluoxetine; Fluvoxamine; Male; Mice; Paroxetine; Penbutolol; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Sertraline; Synaptosomes | 1994 |
Automated determination of paroxetine and its main metabolite by column switching and on-line high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Imipramine; Mixed Function Oxygenases; Paroxetine; Piperidines; Sensitivity and Specificity | 1994 |
Behavioural effects of selective serotonin reuptake inhibitors following direct micro injection into the left red nucleus of the rat.
Topics: 1-Naphthylamine; Animals; Behavior, Animal; Chlorpromazine; Citalopram; Fluoxetine; Fluvoxamine; Guanidines; Haloperidol; Male; Microinjections; Motor Activity; Paroxetine; Piperidines; Posture; Rats; Rats, Sprague-Dawley; Receptors, sigma; Red Nucleus; Selective Serotonin Reuptake Inhibitors; Sertraline | 1997 |
Donepezil and paroxetine: possible drug interaction.
Topics: Aged; Aggression; Akathisia, Drug-Induced; Antidepressive Agents, Second-Generation; Confusion; Diarrhea; Donepezil; Drug Interactions; Female; Flatulence; Humans; Indans; Male; Nootropic Agents; Paroxetine; Piperidines; Sleep Initiation and Maintenance Disorders | 1999 |
Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia.
Topics: Antibodies, Monoclonal; Antidepressive Agents; Antipsychotic Agents; Cell Line; Flupenthixol; gag Gene Products, Human Immunodeficiency Virus; Gene Products, gag; HIV Antigens; HIV Core Protein p24; HIV-1; Humans; Immunohistochemistry; Paroxetine; Piperidines; Viral Proteins; Virus Replication | 2000 |
Drug interactions and donepezil.
Topics: Antidepressive Agents, Second-Generation; Antifungal Agents; Cholinesterase Inhibitors; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Donepezil; Drug Interactions; Enzyme Inhibitors; Humans; Indans; Ketoconazole; Paroxetine; Piperidines | 2000 |
Synthesis of enantiopure trans-3,4-disubstituted piperidines. An enantiodivergent synthesis of (+)- and (-)-paroxetine.
Topics: Antidepressive Agents, Second-Generation; Indicators and Reagents; Paroxetine; Piperidines; Stereoisomerism | 2000 |
Highly diastereoselective and enantioselective carbon-carbon bond formations in conjugate additions of lithiated N-Boc allylamines to nitroalkenes: enantioselective synthesis of 3,4- and 3,4,5-substituted piperidines including (-)-paroxetine.
Topics: Alkenes; Amines; Carbon; Paroxetine; Piperidines; Stereoisomerism | 2001 |
Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Amphetamines; Animals; Electric Stimulation; Electrophysiology; Fluorobenzenes; Idazoxan; Locus Coeruleus; Male; Neurons; Norepinephrine; Paroxetine; Patch-Clamp Techniques; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists | 2001 |
Enzymatic resolution of trans-4-(4'-fluorophenyl)-3-hydroxymethylpiperidines, key intermediates in the synthesis of (-)-Paroxetine.
Topics: Acetylation; Benzene Derivatives; Candida; Hydrolysis; Indicators and Reagents; Lipase; Magnetic Resonance Spectroscopy; Paroxetine; Piperidines; Solvents; Stereoisomerism | 2001 |
Enantiomeric enrichment of (+)-(3R,4S)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by crystallization.
Topics: Crystallization; Humans; Magnetic Resonance Spectroscopy; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Stereoisomerism | 2001 |
Vibrational circular dichroism spectroscopy study of paroxetine and femoxetine precursors.
Topics: Circular Dichroism; Models, Chemical; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors | 2002 |
Anhydrides as acylating agents in the enzymatic resolution of an intermediate of (-)-Paroxetine.
Topics: Acetylation; Anhydrides; Candida; Catalysis; Esterification; Indicators and Reagents; Lipase; Paroxetine; Piperidines; Solvents; Stereoisomerism | 2003 |
Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate-early gene Arc in rat brain.
Topics: Aminopyridines; Animals; Apoptosis Regulatory Proteins; Benzopyrans; Brain Chemistry; Gene Expression; Male; Muscle Proteins; Paroxetine; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists | 2003 |
Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT(1A) receptor antagonism/SSRI activities. Part 2.
Topics: Guanosine 5'-O-(3-Thiotriphosphate); Indicators and Reagents; Paroxetine; Piperidines; Propanols; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Stereoisomerism; Structure-Activity Relationship | 2003 |
Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus.
Topics: Biological Transport, Active; Drug Resistance, Multiple, Bacterial; Hydrogen-Ion Concentration; Membrane Potentials; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Staphylococcus aureus | 2003 |
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3.
Topics: Antidepressive Agents; Guanosine 5'-O-(3-Thiotriphosphate); Indicators and Reagents; Molecular Conformation; Molecular Structure; Paroxetine; Piperidines; Propanols; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Antagonists; Structure-Activity Relationship | 2003 |
Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice.
Topics: Animals; Drug Administration Routes; Extracellular Fluid; Frontal Lobe; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Neurokinin-1 Receptor Antagonists; Paroxetine; Perfusion; Piperidines; Raphe Nuclei; Receptors, Neurokinin-1; Selective Serotonin Reuptake Inhibitors; Serotonin; Tetrazoles | 2004 |
Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps.
Topics: Bacterial Proteins; Biological Transport, Active; Drug Resistance, Multiple, Bacterial; Paroxetine; Piperidines; Staphylococcus aureus; Structure-Activity Relationship | 2004 |
Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats.
Topics: Amantadine; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antiparkinson Agents; Clomipramine; Drug Synergism; Male; Microdialysis; Paroxetine; Piperidines; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin | 2005 |
Convenient synthesis of substituted piperidinones from alpha,beta-unsaturated amides: formal synthesis of deplancheine, tacamonine, and paroxetine.
Topics: Amides; Antidepressive Agents, Second-Generation; Indole Alkaloids; Paroxetine; Piperidines; Stereoisomerism | 2005 |
Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT 1A autoreceptors in mice.
Topics: Animals; Autoradiography; Autoreceptors; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Neurokinin-1 Receptor Antagonists; Paroxetine; Piperidines; Raphe Nuclei; Receptor, Serotonin, 5-HT1A; Receptors, Neurokinin-1; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Tetrazoles | 2005 |
Antidepressant-like activity of selective serotonin reuptake inhibitors combined with a NK1 receptor antagonist in the mouse forced swimming test.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antidepressive Agents; Citalopram; Depressive Disorder; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Escape Reaction; Male; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Swimming; Tetrazoles | 2006 |
SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Benzoxazines; Brain; Callithrix; Drug Synergism; Male; Motor Activity; Paroxetine; Piperidines; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Social Behavior; Vocalization, Animal | 2007 |
Stereospecific construction of substituted piperidines. Synthesis of (-)-paroxetine and (+)-laccarin.
Topics: Indoles; Paroxetine; Piperidines; Stereoisomerism; Sulfonic Acids | 2007 |
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drugs, Investigational; Fluoxetine; Guinea Pigs; Injections, Intraperitoneal; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Swimming; Tranylcypromine | 2007 |
The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration.
Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Brain; Citalopram; Depression; Disease Models, Animal; Fenclonine; Fenfluramine; Fluorobenzenes; Freezing Reaction, Cataleptic; Male; Paroxetine; Piperidines; Protein Binding; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT4; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Swimming; Time Factors; Tritium | 2009 |
Comments on "An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606 in patients with treatment-refractory major depressive disorder".
Topics: Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Drug Resistance; Excitatory Amino Acid Antagonists; Humans; Infusions, Intravenous; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Research Design; Sigma-1 Receptor; Treatment Outcome | 2009 |
NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Immobility Response, Tonic; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Paroxetine; Piperidines; Receptors, N-Methyl-D-Aspartate; Swimming | 2009 |
Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels.
Topics: Aniline Compounds; Animals; Drug Synergism; Extracellular Space; Hippocampus; Hydroxyindoleacetic Acid; Male; Microdialysis; Paroxetine; Piperidines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT4 Receptor Agonists | 2010 |
Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors.
Topics: Animals; Behavior, Animal; Cannabidiol; Diazepam; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Mice; Mice, Inbred C57BL; Motor Activity; Paroxetine; Piperazines; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Synaptic Transmission | 2010 |
Influence of GIRK channel inhibition on alcohol abstinence and relapse risk in Japanese alcohol-dependent outpatients.
Topics: Alcoholism; Analysis of Variance; Asian People; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Haloperidol; Humans; Middle Aged; Outpatients; Paroxetine; Piperidines; Retrospective Studies; Risk; Secondary Prevention; Treatment Outcome | 2011 |
Optically pure γ-butyrolactones and epoxy esters via two stereocentered HKR of 3-substituted epoxy esters: a formal synthesis of (-)-paroxetine, Ro 67-8867 and (+)-eldanolide.
Topics: 4-Butyrolactone; Alkadienes; Catalysis; Epoxy Compounds; Esters; Hydrolysis; Kinetics; Molecular Structure; Optical Phenomena; Organometallic Compounds; Paroxetine; Piperidines; Stereoisomerism | 2013 |
The chemical fate of paroxetine metabolites. Dehydration of radicals derived from 4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine.
Topics: Alkenes; Free Radicals; Imines; Paroxetine; Photolysis; Piperidines; Quantum Theory; Selective Serotonin Reuptake Inhibitors; Thermodynamics; Water | 2013 |
Complexities of personalized medicine: how genes, drug-drug interactions, dosing schedules, and other factors can combine to produce clinically meaningful differences in a drug's effect.
Topics: Affective Disorders, Psychotic; Aged; Antipsychotic Agents; Depressive Disorder, Major; Dizziness; Drug Interactions; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Isoxazoles; Male; Paroxetine; Pharmacogenetics; Piperidines; Precision Medicine | 2013 |
Co-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution.
Topics: Administration, Intravenous; Administration, Oral; Animals; Body Fluids; Carbamates; Cell Separation; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Feces; Hepatocytes; Intestinal Absorption; Liver; Male; Paroxetine; Piperidines; Pravastatin; Rats, Sprague-Dawley; Tissue Distribution | 2015 |
Enantioselective Synthesis of Chiral Piperidines via the Stepwise Dearomatization/Borylation of Pyridines.
Topics: Antidepressive Agents; Catalysis; Dihydropyridines; Molecular Structure; Paroxetine; Piperidines; Pyridines; Stereoisomerism | 2016 |
Influence of the selective antagonist of the NR2B subunit of the NMDA receptor, traxoprodil, on the antidepressant-like activity of desipramine, paroxetine, milnacipran, and bupropion in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Brain; Bupropion; Chromatography, High Pressure Liquid; Cyclopropanes; Depressive Disorder; Desipramine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Male; Mice; Milnacipran; Motor Activity; Paroxetine; Piperidines; Receptors, N-Methyl-D-Aspartate | 2017 |