Page last updated: 2024-08-23

paroxetine and perphenazine

paroxetine has been researched along with perphenazine in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (26.67)18.2507
2000's8 (53.33)29.6817
2010's3 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Begley, A; Cornes, C; Dew, MA; Frank, E; Hall, M; Houck, PR; Kupfer, DJ; Mazumdar, S; Miller, MD; Mulsant, B; Perel, JM; Reynolds, CF; Shear, MK1
Young, C1
Herrmann, N; Kalow, W; Naranjo, CA; Ozdemir, V; Reed, K; Sellers, EM1
Preskorn, SH; Shad, MU1
Bartel, RL; Goodhue, A; Smith, NB1
Preskorn, SH1

Reviews

1 review(s) available for paroxetine and perphenazine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for paroxetine and perphenazine

ArticleYear
High relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depression.
    The American journal of psychiatry, 1996, Volume: 153, Issue:11

    Topics: Age Factors; Age of Onset; Aged; Antidepressive Agents; Combined Modality Therapy; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Female; Hospitalization; Humans; Lithium; Male; Nortriptyline; Paroxetine; Perphenazine; Placebos; Psychotherapy; Recurrence; Risk Factors; Treatment Outcome

1996
Paroxetine potentiates the central nervous system side effects of perphenazine: contribution of cytochrome P4502D6 inhibition in vivo.
    Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:3

    Topics: Adult; Analysis of Variance; Central Nervous System; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dopamine Antagonists; Double-Blind Method; Drug Synergism; Humans; Memory; Middle Aged; Paroxetine; Perphenazine; Psychomotor Performance; Selective Serotonin Reuptake Inhibitors

1997

Other Studies

12 other study(ies) available for paroxetine and perphenazine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
A case of neuroleptic malignant syndrome and serotonin disturbance.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:1

    Topics: Akathisia, Drug-Induced; Benztropine; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Lithium Carbonate; Middle Aged; Neuroleptic Malignant Syndrome; Neurologic Examination; Paroxetine; Perphenazine; Receptors, Serotonin; Trazodone

1997
Pharmacodynamic and pharmacokinetic factors in a case of neuroleptic malignant syndrome.
    Journal of clinical psychopharmacology, 1998, Volume: 18, Issue:4

    Topics: Antipsychotic Agents; Brain; Drug Interactions; Drug Therapy, Combination; Humans; Lithium Carbonate; Neuroleptic Malignant Syndrome; Paroxetine; Perphenazine; Selective Serotonin Reuptake Inhibitors; Trazodone

1998
Exacerbation of psychosis by phenylpropanolamine.
    The American journal of psychiatry, 2000, Volume: 157, Issue:6

    Topics: Adult; Female; Hallucinations; Humans; Methamphetamine; Nasal Decongestants; Paranoid Disorders; Paroxetine; Perphenazine; Phenylpropanolamine; Psychoses, Substance-Induced; Recurrence; Substance-Related Disorders

2000
Neuroleptic malignant syndrome resulting from a complex drug-drug interaction: "I don't see 'em!".
    Journal of psychiatric practice, 2007, Volume: 13, Issue:5

    Topics: Benztropine; Bipolar Disorder; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Drug Therapy, Combination; Female; Humans; Lithium Compounds; Middle Aged; Neuroleptic Malignant Syndrome; Paroxetine; Perphenazine; Psychotropic Drugs; Trazodone

2007