Page last updated: 2024-08-23

paroxetine and oxycodone

paroxetine has been researched along with oxycodone in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's3 (27.27)29.6817
2010's5 (45.45)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Lurcott, G1
Grönlund, J; Hagelberg, NM; Laine, K; Neuvonen, PJ; Olkkola, KT; Saari, TI2
Drewe, J; Hammann, F; Krähenbühl, S; Kummer, O; Moser, C; Schaller, O1
Bykov, K; Gagne, JJ; Yoshida, K; Yunusa, I1
Boughner, R; Burkhart, K; Dahan, A; Davis, MC; Florian, J; Ford, K; Gershuny, V; Han, X; Ismaiel, OA; Matta, M; Patel, V; Prentice, K; Racz, R; Rouse, R; Sanabria, C; Shah, A; Stone, M; Strauss, DG; van der Schrier, R; Wang, C; Weaver, J1

Reviews

2 review(s) available for paroxetine and oxycodone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The effects of the genetic absence and inhibition of CYP2D6 on the metabolism of codeine and its derivatives, hydrocodone and oxycodone.
    Anesthesia progress, 1998,Fall, Volume: 45, Issue:4

    Topics: Analgesics, Opioid; Anti-Arrhythmia Agents; Binding, Competitive; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Fluoxetine; Humans; Hydrocodone; Oxycodone; Paroxetine; Quinidine; Selective Serotonin Reuptake Inhibitors

1998

Trials

4 trial(s) available for paroxetine and oxycodone

ArticleYear
Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone.
    British journal of clinical pharmacology, 2010, Volume: 70, Issue:1

    Topics: Adult; Cross-Over Studies; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Itraconazole; Male; Oxycodone; Paroxetine; Young Adult

2010
Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone.
    European journal of clinical pharmacology, 2011, Volume: 67, Issue:1

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Double-Blind Method; Drug Interactions; Genotype; Humans; Ketoconazole; Miosis; Morphinans; Oxycodone; Oxymorphone; Pain Measurement; Paroxetine; Placebos; Young Adult

2011
Effect of inhibition of cytochrome P450 enzymes 2D6 and 3A4 on the pharmacokinetics of intravenous oxycodone: a randomized, three-phase, crossover, placebo-controlled study.
    Clinical drug investigation, 2011, Volume: 31, Issue:3

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Half-Life; Humans; Itraconazole; Male; Oxycodone; Paroxetine; Young Adult

2011
Effect of Paroxetine or Quetiapine Combined With Oxycodone vs Oxycodone Alone on Ventilation During Hypercapnia: A Randomized Clinical Trial.
    JAMA, 2022, 10-11, Volume: 328, Issue:14

    Topics: Adult; Analgesics, Opioid; Antidepressive Agents; Benzodiazepines; Carbon Dioxide; Double-Blind Method; Female; Humans; Hypercapnia; Oxycodone; Paroxetine; Quetiapine Fumarate; Respiration; Respiratory Insufficiency

2022

Other Studies

5 other study(ies) available for paroxetine and oxycodone

ArticleYear
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Risk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors.
    JAMA network open, 2022, 02-01, Volume: 5, Issue:2

    Topics: Adult; Aged; Analgesics, Opioid; Cohort Studies; Comorbidity; Depression; Emergency Medical Services; Female; Fluoxetine; Hospitalization; Humans; Male; Middle Aged; Opiate Overdose; Oxycodone; Pain; Paroxetine; Selective Serotonin Reuptake Inhibitors

2022