Page last updated: 2024-08-23

paroxetine and metoprolol

paroxetine has been researched along with metoprolol in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (9.68)	18.2507
2000's	12 (38.71)	29.6817
2010's	15 (48.39)	24.3611
2020's	1 (3.23)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Dalvie, D; Loi, CM; Smith, DA	1
Bellman, K; Knegtel, RM; Settimo, L	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Häfele, M; Hauger, B; König, F; Löble, M; Wolfersdorf, M; Wössner, S	1
Artigas, F; Franchini, L; Gasperini, M; Perez, J; Sforzini, L; Smeraldi, E; Zanardi, R	1
Belpaire, FM; Brøsen, K; Rasmussen, BB; Temmerman, A; Wijnant, P	1
Belpaire, FM; De Vriendt, C; Hemeryck, A; Lefebvre, RA	1
Cha, IJ; Cha, YN; Flockhart, DA; Jang, IJ; Kim, KA; Park, CW; Shin, JG; Shin, SG; Shon, JH; Yoon, YR	1
Belpaire, FM; De Vriendt, CA; Hemeryck, A	1
Babak, S; Bergman, U; Bertilsson, L; Boldueva, S; Burbello, A; Goryachkina, K	1
Bekar, L; Cumurcu, BE; Onalan, O	1
Corti, N; Elke, B; Locher, P; Wagner, CC	1
Bleske, BE; Brook, R; Kerber, K; Nielsen, J; Shea, M; Stout, SM; Welage, LS	1
Parker, RB; Soberman, JE	1
Molden, E; Spigset, O	1
Hori, S; Mikami, A; Ohtani, H; Sawada, Y	1
Bahar, MA; Borgsteede, SD; Bos, JHJ; Hak, E; Wilffert, B	1
Bahar, MA; Bos, JHJ; Hak, E; Wang, Y; Wilffert, B	1
Bahar, MA; Borgsteede, SD; Hak, E; Kamp, J; Wilffert, B	1
Gedde-Dahl, A; Molden, E; Spigset, O	1

Reviews

4 review(s) available for paroxetine and metoprolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Frequent drug interactions in old age]. Praxis, 2009, Oct-21, Volume: 98, Issue:21 Topics: Adrenergic beta-Antagonists; Age Factors; Antihypertensive Agents; Cytochrome P-450 Enzyme System; Depression; Diuretics; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Heart Failure; Humans; Metoprolol; Paroxetine; Polypharmacy; Risk Factors; Sulfonamides; Torsemide	2009
[Interactions between metoprolol and antidepressants]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2011, Sep-20, Volume: 131, Issue:18 Topics: Adrenergic beta-1 Receptor Antagonists; Antidepressive Agents; Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Metoprolol; Paroxetine; Risk Factors	2011
The impact of CYP2D6 mediated drug-drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine. British journal of clinical pharmacology, 2018, Volume: 84, Issue:12 Topics: Cytochrome P-450 CYP2D6; Drug Interactions; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Metoprolol; Middle Aged; Paroxetine	2018

Trials

5 trial(s) available for paroxetine and metoprolol

Article	Year
How long should pindolol be associated with paroxetine to improve the antidepressant response? Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Female; Headache; Humans; Male; Metoprolol; Middle Aged; Paroxetine; Pindolol; Selective Serotonin Reuptake Inhibitors; Time Factors	1997
Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Antihypertensive Agents; Area Under Curve; Chromatography, High Pressure Liquid; Drug Administration Schedule; Half-Life; Humans; Male; Metoprolol; Paroxetine; Reference Values; Selective Serotonin Reuptake Inhibitors	2000
Inhibition of metoprolol metabolism and potentiation of its effects by paroxetine in routinely treated patients with acute myocardial infarction (AMI). European journal of clinical pharmacology, 2008, Volume: 64, Issue:3 Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Area Under Curve; Bradycardia; Cytochrome P-450 CYP2D6; Depression; Dose-Response Relationship, Drug; Drug Interactions; Female; Genotype; Heart Rate; Humans; Hypotension, Orthostatic; Male; Metoprolol; Middle Aged; Myocardial Infarction; Paroxetine	2008
Influence of metoprolol dosage release formulation on the pharmacokinetic drug interaction with paroxetine. Journal of clinical pharmacology, 2011, Volume: 51, Issue:3 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Cross-Over Studies; Cytochrome P-450 CYP2D6 Inhibitors; Delayed-Action Preparations; Drug Interactions; Enzyme Inhibitors; Humans; Male; Metabolic Clearance Rate; Metoprolol; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors; Stereoisomerism; Young Adult	2011
Effects of paroxetine on the pharmacokinetics and pharmacodynamics of immediate-release and extended-release metoprolol. Pharmacotherapy, 2011, Volume: 31, Issue:7 Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Area Under Curve; Blood Pressure; Cross-Over Studies; Cytochrome P-450 CYP2D6; Delayed-Action Preparations; Drug Interactions; Female; Half-Life; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Paroxetine; Prospective Studies; Selective Serotonin Reuptake Inhibitors; Stereoisomerism; Young Adult	2011

Other Studies

22 other study(ies) available for paroxetine and metoprolol

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
[Bradycardia after beginning therapy with metoprolol and paroxetine]. Psychiatrische Praxis, 1996, Volume: 23, Issue:5 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Second-Generation; Blood Pressure; Bradycardia; Cardiomyopathy, Hypertrophic; Depressive Disorder; Drug Therapy, Combination; Electrocardiography; Female; Heart Rate; Humans; Lithium Carbonate; Metoprolol; Middle Aged; Paroxetine	1996
The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors. European journal of clinical pharmacology, 1998, Volume: 54, Issue:3 Topics: 1-Naphthylamine; Adult; Anti-Arrhythmia Agents; Child; Citalopram; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Fluoxetine; Fluvoxamine; Humans; Hydroxylation; Kinetics; Male; Methylation; Metoprolol; Microsomes, Liver; Oxidation-Reduction; Paroxetine; Quinidine; Selective Serotonin Reuptake Inhibitors; Sertraline	1998
Relationship of paroxetine disposition to metoprolol metabolic ratio and CYP2D610 genotype of Korean subjects. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:5* Topics: Administration, Oral; Adult; Area Under Curve; Asian People; Case-Control Studies; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Korea; Male; Metoprolol; Paroxetine; Polymerase Chain Reaction; Selective Serotonin Reuptake Inhibitors; Sympatholytics	2000
Metoprolol-paroxetine interaction in human liver microsomes: stereoselective aspects and prediction of the in vivo interaction. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:5 Topics: Adrenergic beta-Antagonists; Area Under Curve; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Metoprolol; Microsomes, Liver; Paroxetine; Selective Serotonin Reuptake Inhibitors	2001
Complete atrioventricular block associated with concomitant use of metoprolol and paroxetine. Mayo Clinic proceedings, 2008, Volume: 83, Issue:5 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atrioventricular Block; Atrioventricular Node; Bradycardia; Cytochrome P-450 CYP2D6; Drug Synergism; Electrocardiography, Ambulatory; Female; Humans; Liver; Metoprolol; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors	2008
Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine. International journal of clinical pharmacology and therapeutics, 2013, Volume: 51, Issue:5 Topics: Anti-Arrhythmia Agents; Antidepressive Agents; Biotransformation; Chemistry, Pharmaceutical; Computer Simulation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Delayed-Action Preparations; Drug Dosage Calculations; Drug Interactions; Enzyme Inhibitors; Humans; Metoprolol; Models, Biological; Nonlinear Dynamics; Paroxetine	2013
The burden and management of cytochrome P450 2D6 (CYP2D6)-mediated drug-drug interaction (DDI): co-medication of metoprolol and paroxetine or fluoxetine in the elderly. Pharmacoepidemiology and drug safety, 2017, Volume: 26, Issue:7 Topics: Aged; Anti-Arrhythmia Agents; Cytochrome P-450 CYP2D6; Drug Interactions; Female; Fluoxetine; Humans; Male; Metoprolol; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors	2017
Discontinuation and dose adjustment of metoprolol after metoprolol-paroxetine/fluoxetine co-prescription in Dutch elderly. Pharmacoepidemiology and drug safety, 2018, Volume: 27, Issue:6 Topics: Aged; Aged, 80 and over; Citalopram; Cohort Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Prescriptions; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Metoprolol; Middle Aged; Mirtazapine; Netherlands; Paroxetine	2018
Co-prescription of metoprolol and CYP2D6-inhibiting antidepressants before and after implementation of an optimized drug interaction database in Norway. European journal of clinical pharmacology, 2022, Volume: 78, Issue:10 Topics: Antidepressive Agents; Atenolol; Bisoprolol; Bupropion; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Drug Prescriptions; Fluoxetine; Humans; Metoprolol; Paroxetine; Retrospective Studies	2022