Page last updated: 2024-08-23

paroxetine and diazepam

paroxetine has been researched along with diazepam in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.03)18.7374
1990's1 (3.03)18.2507
2000's14 (42.42)29.6817
2010's16 (48.48)24.3611
2020's1 (3.03)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Artursson, P; Mateus, A; Matsson, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bannister, SJ; Houser, VP; Hulse, JD; Kisicki, JC; Rasmussen, JG1
Dekeyne, A; Girardon, S; Gobert, A; Millan, MJ1
Couvée, JE; Zitman, FG1
Aida, R; Akiyama, M; Moriya, T; Shibata, S; Shimomura, H; Takahashi, S; Yoshinobu, Y1
Borgheini, G1
Ben-Amir, E; Doljansky, J; Flaisher, S; Joel, D1
Blin, D; Derderian, F; Durand, M; Gonthier, YT; Mongenot, F1
Agius, M; Biocina-Martić, S; Dordević, V; Gruber, EN1
Bespalov, AY; Gross, G; Mezler, M; Schoemaker, H; Sukhotina, IA; van Gaalen, MM; Wicke, K1
Casarotto, PC; Gomes, FV; Guimarães, FS; Resstel, LB1
Chino, A; Kasahara, Y; Namiki, T; Ogawa, K; Okamoto, H; Terasawa, K; Ueda, K1
Neumann, ID; Slattery, DA; Toth, I1
Aleksic, B; Ebe, K; Iwamoto, K; Kawamura, Y; Kawano, N; Kunimoto, S; Noda, Y; Ozaki, N; Takahashi, M; Tamaji, A1
Gross, M; Lisson, S; Nesher, E; Pinhasov, A; Tikhonov, T; Yadid, G1
Kabata, P; Sein Anand, J; Waldman, W1
Orlando, JM1
Barbui, C; Bighelli, I; Caldwell, DM; Cipriani, A; Davies, SJ; Dawson, S; Dias, S; Furukawa, TA; Guaiana, G; Imai, H; Koesters, M; Meader, N; Pompoli, A; Robertson, L; Tajika, A1

Reviews

3 review(s) available for paroxetine and diazepam

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The bioequivalence and therapeutic efficacy of generic versus brand-name psychoactive drugs.
    Clinical therapeutics, 2003, Volume: 25, Issue:6

    Topics: Anticonvulsants; Biological Availability; Clinical Trials as Topic; Clozapine; Diazepam; Drug Approval; Drugs, Generic; Excipients; Humans; Paroxetine; Psychotropic Drugs; Therapeutic Equivalency

2003
Pharmacological treatments in panic disorder in adults: a network meta-analysis.
    The Cochrane database of systematic reviews, 2023, 11-28, Volume: 11

    Topics: Adult; Alprazolam; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipramine; Clonazepam; Desipramine; Diazepam; Fluoxetine; Humans; Network Meta-Analysis; Panic Disorder; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Venlafaxine Hydrochloride

2023

Trials

2 trial(s) available for paroxetine and diazepam

ArticleYear
Chronic benzodiazepine use in general practice patients with depression: an evaluation of controlled treatment and taper-off: report on behalf of the Dutch Chronic Benzodiazepine Working Group.
    The British journal of psychiatry : the journal of mental science, 2001, Volume: 178

    Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Depressive Disorder; Diazepam; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Paroxetine; Sample Size; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome

2001
Differential effects of diazepam, tandospirone, and paroxetine on plasma brain-derived neurotrophic factor level under mental stress.
    Human psychopharmacology, 2012, Volume: 27, Issue:3

    Topics: Adult; Anti-Anxiety Agents; Automobile Driving; Brain-Derived Neurotrophic Factor; Cross-Over Studies; Diazepam; Double-Blind Method; Female; Gene Expression Regulation; Humans; Isoindoles; Male; Paroxetine; Piperazines; Pyrimidines; Statistics, Nonparametric; Stress, Psychological; Time Factors

2012

Other Studies

28 other study(ies) available for paroxetine and diazepam

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
    Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19

    Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution

2011
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin.
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

    Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Diazepam; Digoxin; Drug Interactions; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists; Warfarin

1989
Citalopram elicits a discriminative stimulus in rats at a dose selectively increasing extracellular levels of serotonin vs. dopamine and noradrenaline.
    European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3

    Topics: Animals; Biogenic Monoamines; Cerebral Cortex; Citalopram; Clozapine; Corpus Striatum; Diazepam; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; GABA Agents; Male; Norepinephrine; Nucleus Accumbens; Paroxetine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline

1999
Extended action of MKC-242, a selective 5-HT(1A) receptor agonist, on light-induced Per gene expression in the suprachiasmatic nucleus in mice.
    Journal of neuroscience research, 2002, May-15, Volume: 68, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Cell Cycle Proteins; Circadian Rhythm; Diazepam; Dioxanes; Dioxoles; GABA Modulators; Gene Expression Regulation; In Situ Hybridization; Light; Male; Mice; Motor Activity; Nuclear Proteins; Paroxetine; Period Circadian Proteins; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Suprachiasmatic Nucleus; Transcription Factors

2002
'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam.
    Behavioural pharmacology, 2004, Volume: 15, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Compulsive Behavior; Conditioning, Operant; Desipramine; Diazepam; Dose-Response Relationship, Drug; Extinction, Psychological; Fluvoxamine; Male; Paroxetine; Rats; Rats, Wistar; Reward; Selective Serotonin Reuptake Inhibitors

2004
[Treatment of hydroxychloroquine poisoning with extracorporeal circulation].
    Annales francaises d'anesthesie et de reanimation, 2007, Volume: 26, Issue:2

    Topics: Adult; Antidotes; Bromazepam; Charcoal; Coma; Combined Modality Therapy; Diazepam; Drug Overdose; Epinephrine; Extracorporeal Circulation; Female; Fluid Therapy; Gastric Lavage; Heart Massage; Humans; Hydroxychloroquine; Hypokalemia; Paroxetine; Plasma Substitutes; Potassium; Pyridines; Shock, Cardiogenic; Sodium Channel Blockers; Suicide, Attempted; Vasoconstrictor Agents; Ventricular Fibrillation; Zolpidem

2007
"My new Alfa Romeo GT is not in the garage any more": Cognitive behavioural therapy of panic disorder with agoraphobia co morbid with psychosis.
    Psychiatria Danubina, 2006, Volume: 18, Issue:3-4

    Topics: Adult; Agoraphobia; Antipsychotic Agents; Atenolol; Benzodiazepines; Cognitive Behavioral Therapy; Combined Modality Therapy; Desensitization, Psychologic; Diazepam; Hospitalization; Humans; Male; Olanzapine; Panic Disorder; Paroxetine; Psychotic Disorders; Reality Testing; Socialization

2006
Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression.
    European journal of pharmacology, 2008, Sep-11, Volume: 592, Issue:1-3

    Topics: Amino Acids; Amphetamine; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Conditioning, Operant; Darkness; Depression; Diazepam; Fever; Fluoxetine; Light; Male; Mice; Paroxetine; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Stress, Psychological; Xanthenes

2008
Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors.
    Behavioural pharmacology, 2010, Volume: 21, Issue:4

    Topics: Animals; Behavior, Animal; Cannabidiol; Diazepam; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Mice; Mice, Inbred C57BL; Motor Activity; Paroxetine; Piperazines; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Synaptic Transmission

2010
A case of thalamic pain successfully treated with Kampo medicine.
    Journal of alternative and complementary medicine (New York, N.Y.), 2011, Volume: 17, Issue:6

    Topics: Aged; Analgesics; Diazepam; Female; Humans; Infarction; Medicine, Kampo; Movement Disorders; Nausea; Pain; Paroxetine; Phytotherapy; Plant Extracts; Sensation Disorders; Stroke; Thalamus

2011
Social fear conditioning: a novel and specific animal model to study social anxiety disorder.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Conditioning, Psychological; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Exploratory Behavior; Extinction, Psychological; Fear; Male; Maze Learning; Mental Recall; Paroxetine; Phobic Disorders; Swimming; Time Factors

2012
Differential responses to distinct psychotropic agents of selectively bred dominant and submissive animals.
    Behavioural brain research, 2013, Jan-01, Volume: 236, Issue:1

    Topics: Aggression; Analysis of Variance; Animals; Antimanic Agents; Anxiety; Behavior, Animal; Diazepam; Dominance-Subordination; Drinking; Hypnotics and Sedatives; Lithium Chloride; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Paroxetine; Psychotropic Drugs; Selective Serotonin Reuptake Inhibitors; Swimming

2013
Double, suicidal intoxication with hydroxycarbamide--a case report.
    Przeglad lekarski, 2012, Volume: 69, Issue:8

    Topics: Adult; Complex Mixtures; Diazepam; Drug Overdose; Ethanol; Female; Humans; Hydroxyurea; Paroxetine; Suicide, Attempted; Thrombocytosis

2012
Animal Behavior Case of the Month.
    Journal of the American Veterinary Medical Association, 2017, 11-01, Volume: 251, Issue:9

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Behavior, Animal; Diazepam; Dog Diseases; Dogs; Fear; Fluoxetine; Gabapentin; Male; Noise; Paroxetine; Phobic Disorders

2017