Page last updated: 2024-08-23

paroxetine and desipramine

paroxetine has been researched along with desipramine in 111 studies

Research

Studies (111)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (1.80)	18.7374
1990's	37 (33.33)	18.2507
2000's	48 (43.24)	29.6817
2010's	21 (18.92)	24.3611
2020's	3 (2.70)	2.80

Authors

Authors	Studies
Goodman, MM; Kabalka, GW; Kung, HF; Kung, MP; Switzer, R	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Dansette, PM; Fontana, E; Poli, SM	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Buck, LB; Petrascheck, M; Ye, X	1
Lombardo, F; Obach, RS; Waters, NJ	1
Alfinito, P; Bray, J; Cohn, ST; Deecher, DC; Fensome, A; Johnston, G; Koury, E; Mahaney, PE; Marella, MA; McComas, CC; Nogle, L; Trybulski, EJ; Vu, AT; Ye, F; Zhang, P	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C	1
Dalvie, D; Loi, CM; Smith, DA	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Bowery, NG; Johnson, AM; Nelson, DR; Palmer, KJ; Pratt, GD	1
Insel, TR; Winslow, JT	1
Brøsen, K; Eshøj, O; Gram, LF; Mogensen, EF; Sindrup, SH	1
Brunello, N; Galimberti, R; Racagni, G; Riva, M; Rovescalli, AC	1
Clausing, R; Göthert, M; Schlicker, E	1
Beauchemin, V; Dennis, T; Lavoie, N	2
Blackburn, TP; de Biasi, V; Kennett, GA; Lightowler, S; Stevens, NC; Tulloch, IF; Wood, MD	1
Court, MH; Duan, SX; Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL	1
Falkowski, J; Horton, RW; Jacobson, RR; Lawrence, KM	1
Asai, K; Mori, H; Nankai, M; Toru, M; Watanabe, A; Yamada, S; Yoshimoto, S	1
Cheng, CH; Costall, B; Naylor, RJ; Rudd, JA	1
Andrews, AM; Murphy, DL	1
Dannals, RF; Ravert, HT; Ricaurte, GA; Scheffel, U; Suehiro, M; Wagner, HN	1
Brøsen, K; Gram, LF; Hansen, JG; Nielsen, KK; Sindrup, SH	1
Burke, MJ; Harvey, AT; Preskorn, SH	1
Preskorn, SH	1
Albers, LJ; Helmeste, D; Reist, C; Tang, SW; Vu, R	1
Bourin, M; Pinot, P; Redrobe, JP	1
Landry, P; Roy, L	1
Abraham, P; Carroll, FI; Kopajtic, T; Kuhar, MJ; Lever, JR; Mathews, WB; Parham, KR; Scheffel, U	1
Carroll, FI; Holmquist, CR; Kepler, JA; Kuhar, MJ; Saindane, AM; Scheffel, U; Taylor, GF; Zhan, Y	1
Ahern, D; Ball, SE; Kao, J; Scatina, J	1
Alderman, J; Allison, J; Chung, M; Greenblatt, DJ; Harrison, W; Penenberg, D; Preskorn, SH	1
Bagby, RM; Dickens, SE; Joffe, R; Kennedy, SH; Levitt, A; Minifie, CE; Schuller, DR	1
Costentin, J; Passera, G; Vaugeois, JM; Zuccaro, F	1
Vermeulen, T	1
Béïque, JC; Blier, P; de Montigny, C; Debonnel, G	3
Bitsios, P; Bradshaw, CM; Szabadi, E	1
Hannon, SD; Martin, KF; Redfern, PH; Sayer, TJ	1
Kristensen, AS; Mortensen, OV; Rudnick, G; Wiborg, O	1
Bagby, RM; Joffe, RT; Kennedy, SH; Levitan, RD; Levitt, AJ	1
Abdelmawla, AH; Bradshaw, CM; Langley, RW; Szabadi, E	1
Fujiseki, Y; Inagaki, C; Kinoshita, T; Okugawa, G; Omori, K; Suzukawa, J	1
Benmansour, S; Cecchi, M; Frazer, A; Gerhardt, GA; Gould, GG; Javors, MA; Morilak, DA	1
Connor, TJ; Kelly, JP; Leonard, BE; Nolan, Y; Shen, Y	1
Ashton, AK	1
Connor, TJ; Harkin, A; Kelliher, P; Kelly, JP; Leonard, BE; Shen, Y	1
Hajós-Korcsok, E; McTavish, SF; Sharp, T	1
Draganich, LF; Karrison, T; Klafta, J; Zacny, J	1
Nakash, R; Overstreet, DH; Yadid, G; Zangen, A	1
Misane, I; Ogren, SO	1
Gilmor, ML; Nemeroff, CB; Owens, MJ	1
Beyer, CE; Boikess, S; Dawson, LA; Luo, B	1
Del Río, J; Frechilla, D; Martinez-Turrillas, R	3
Ayan-Oshodi, M; Gonzales, CR; Knadler, MP; Kuan, HY; Lim, M; Pan, A; Reddy, S; Sathirakul, K; Skinner, MH; Wise, SD; Yeo, KP	1
Bourin, M; Dailly, E; David, DJ; Hascoët, M; Ripoll, N	1
Pei, Q; Sharp, T; Sprakes, M; Tordera, R; Zetterström, TS	1
Berman, N; Bowden, CL; Brannan, S; Frazer, A; Houston, JP; Katz, MM; Tekell, JL	1
Altamirano, AV; Benmansour, S; Frazer, A; Gould, GG; Jones, DJ; Morilak, DA; Pardon, MC; Sanchez, TA	1
Cryan, JF; Dalvi, A; Friedland, JC; Hirsch, BR; Jin, SH; Lucki, I; O'Leary, OF; Ouyang, M; Page, ME; Thomas, SA	1
Ben-Amir, E; Doljansky, J; Flaisher, S; Joel, D	1
Carey, GJ; Gold, LH; Nielsen, DM	1
Amsterdam, JD; Brown, LL; DeRubeis, RJ; Gallop, R; Gladis, MM; Hollon, SD; Lovett, ML; O'Reardon, JP; Salomon, RM; Shelton, RC; Young, PR	1
Pei, Q; Sharp, T; Tordera, RM	1
Altamirano, AV; Frazer, A; Gould, GG; Javors, MA	1
Nakamura, J; Shinkai, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N; Yoshimura, R	1
Evans, DL; Goodkin, R; Guo, Y; Lawson, D; Lawson, K; Lewison, B; Manatunga, AK; Musselman, DL; Nemeroff, CB; Penna, S; Porter, M; Somerset, WI	1
Frazer, A; Gould, GG; Javors, MA	1
Blier, P; de Montigny, C; Debonnel, G; Hébert, C; Lavoie, N; Saint-André, E	1
Bourin, M; Chenu, F; Dailly, E	1
Bourin, M; Chenu, F; Gardier, AM; Guiard, BP	1
Eastwood, BJ; Jones, CK; Need, AB; Shannon, HE	1
Allain, H; Bentué-Ferrer, D; Bourin, M; Drapier, D; Laviolle, B; Millet, B; Reymann, JM	1
Berman, N; Bowden, CL; Frazer, A; Katz, MM	1
Gross, G; Groth, I; Jongen-Relo, A; Rex, A; Wicke, KM	1
Borah, M; Radhakrishnan, M; Ramamoorthy, R	1
Crowley, JJ; Hill, TI; Hoshaw, BA; Khawaja, X; Lucki, I; Malberg, JE; Rosenzweig-Lipson, S; Schechter, LE	1
Ahmed, S; Fatato, P; Isler, JA; Jiang, Q; Nichols, AI; Patroneva, A; Paul, J; Pedersen, RD; Shenouda, M	1
Guico-Pabia, CJ; Helzner, EC; Nichols, AI; Patroneva, AL; Paul, J; Preskorn, SH	1
Friedman, A; Lax, E; Lubin, N; Merenlender, A; Rosenstein, M; Yadid, G	1
Bekkering, GE; Tuinier, S; Verbeeck, W	1
Aburakawa, Y; Aizawa, H; Hasebe, N; Kwak, S; Sawada, J; Yamashita, T	1
De Keyser, J; Glazenborg, A; Koch, MW; Mostert, J; Uyttenboogaart, M	1
Asakura, M; Fujiwara, K; Kanai, S; Nakano, M; Osada, K; Sasuga, Y; Tanaka, D; Yanagida, T	1
Hetzenauer, A; Sartori, SB; Singewald, N; Whittle, N	1
Hisaoka-Nakashima, K; Kajitani, N; Morinobu, S; Okada-Tsuchioka, M; Segawa, M; Shibasaki, C; Takebayashi, M	1
Akindipe, TO; Ipser, JC; Sager, C; Stein, DJ; Wilson, D	1
Ago, Y; Hasebe, S; Hashimoto, H; Matsuda, T; Nishiyama, S; Oka, S; Takuma, K	1
Buoli, M; Cahn, W; Serati, M	1
Cipriani, A; Coghill, D; Cohen, D; Cuijpers, P; Del Giovane, C; Hazell, P; Hetrick, SE; Leucht, S; Liu, L; Liu, Y; Michael, KD; Pu, J; Qin, B; Ravindran, AV; Whittington, C; Xie, P; Yang, L; Zhang, Y; Zhou, X	1
Jiang, CL; Liu, WZ; Shang, ZL; Wang, W; Xiang, ZH	1
Dudka, J; Poleszak, E; Serefko, A; Stasiuk, W; Świąder, K; Szopa, A; Wlaź, P; Wyska, E	1
Arroo, R; Jaddoa, E; Masania, J; Masiero, E; Sgamma, T; Sillence, D; Zetterström, T	1
Arranz, B; Arrojo, M; Becoña, E; Bernardo, M; Castells, X; Cunill, R; Flórez, G; Fonseca, F; Garriga, M; Goikolea, JM; González-Pinto, A; López, A; Sáiz, PA; San, L; Tirado-Muñoz, J; Torrens, M; Zorrilla, I	1
Barbui, C; Bighelli, I; Caldwell, DM; Cipriani, A; Davies, SJ; Dawson, S; Dias, S; Furukawa, TA; Guaiana, G; Imai, H; Koesters, M; Meader, N; Pompoli, A; Robertson, L; Tajika, A	1

Reviews

10 review(s) available for paroxetine and desipramine

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Effect of desvenlafaxine on the cytochrome P450 2D6 enzyme system. Journal of psychiatric practice, 2008, Volume: 14, Issue:6 Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Cytochrome P-450 CYP2D6; Depressive Disorder, Major; Desipramine; Desvenlafaxine Succinate; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Health Status; Humans; Paroxetine; Thiophenes	2008
Antidepressants in the treatment of adult attention-deficit hyperactivity disorder: a systematic review. Advances in therapy, 2009, Volume: 26, Issue:2 Topics: Adrenergic Uptake Inhibitors; Adult; Age Factors; Antidepressive Agents; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Bupropion; Comorbidity; Desipramine; Evidence-Based Medicine; Humans; Lithium Carbonate; Monoamine Oxidase Inhibitors; Paroxetine; Randomized Controlled Trials as Topic; Research Design; Selective Serotonin Reuptake Inhibitors; Treatment Outcome	2009
Pharmacologic treatment of depression in multiple sclerosis. The Cochrane database of systematic reviews, 2011, Feb-16, Issue:2 Topics: Adult; Antidepressive Agents; Depression; Desipramine; Humans; Multiple Sclerosis; Paroxetine; Randomized Controlled Trials as Topic	2011
Pharmacotherapy for anxiety and comorbid alcohol use disorders. The Cochrane database of systematic reviews, 2015, Jan-20, Volume: 1 Topics: Alcohol-Related Disorders; Anxiety; Anxiety Disorders; Buspirone; Comorbidity; Desipramine; Humans; Paroxetine; Phobia, Social; Publication Bias; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Sertraline; Stress Disorders, Post-Traumatic	2015
Alternative pharmacological strategies for adult ADHD treatment: a systematic review. Expert review of neurotherapeutics, 2016, Volume: 16, Issue:2 Topics: Adrenergic alpha-Agonists; Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Central Nervous System Stimulants; Desipramine; Dopamine Agents; Droxidopa; Drug Combinations; Duloxetine Hydrochloride; Guanfacine; Histamine Agents; Humans; Lisdexamfetamine Dimesylate; Lithium Compounds; Lobeline; Mecamylamine; Memantine; Modafinil; Morpholines; Nicotinic Agonists; Nicotinic Antagonists; Nomifensine; Paroxetine; Pyridines; Pyridoxine; Pyrrolidonecarboxylic Acid; Quinazolinones; Reboxetine; Venlafaxine Hydrochloride; Wakefulness-Promoting Agents	2016
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis. Lancet (London, England), 2016, Aug-27, Volume: 388, Issue:10047 Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Confounding Factors, Epidemiologic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Evidence-Based Medicine; Fluoxetine; Humans; Imipramine; Mianserin; Mirtazapine; Nortriptyline; Paroxetine; Piperazines; Randomized Controlled Trials as Topic; Research Design; Sertraline; Treatment Outcome; Triazoles; Venlafaxine Hydrochloride	2016
Clinical practice guideline on pharmacological and psychological management of adult patients with an anxiety disorder and comorbid substance use. Adicciones, 2022, Apr-01, Volume: 34, Issue:2 Topics: Adult; Anxiety Disorders; Desipramine; Humans; Naltrexone; Paroxetine; Substance-Related Disorders	2022
Pharmacological treatments in panic disorder in adults: a network meta-analysis. The Cochrane database of systematic reviews, 2023, 11-28, Volume: 11 Topics: Adult; Alprazolam; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipramine; Clonazepam; Desipramine; Diazepam; Fluoxetine; Humans; Network Meta-Analysis; Panic Disorder; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Venlafaxine Hydrochloride	2023

Trials

13 trial(s) available for paroxetine and desipramine

Article	Year
The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain, 1990, Volume: 42, Issue:2 Topics: Depression; Desipramine; Diabetic Neuropathies; Humans; Imipramine; Nervous System; Osmolar Concentration; Paroxetine; Piperidines; Serotonin Antagonists; Time Factors	1990
Desipramine pharmacokinetics when coadministered with paroxetine or sertraline in extensive metabolizers. Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:4 Topics: 1-Naphthylamine; Adolescent; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Area Under Curve; Cross-Over Studies; Desipramine; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Humans; Male; Middle Aged; Paroxetine; Sertraline	1997
Differential pharmacological treatment response in high angry hostile and low angry hostile depressed patients: a retrospective analysis. Journal of affective disorders, 1997, Volume: 45, Issue:3 Topics: 1-Naphthylamine; Adult; Ambulatory Care; Analysis of Variance; Anger; Cyclohexanols; Depressive Disorder; Desipramine; Female; Hostility; Humans; Male; Paroxetine; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Sertraline; Treatment Outcome; Venlafaxine Hydrochloride	1997
Comparison of the effects of venlafaxine, paroxetine and desipramine on the pupillary light reflex in man. Psychopharmacology, 1999, Volume: 143, Issue:3 Topics: Adrenergic Uptake Inhibitors; Adult; Cross-Over Studies; Cyclohexanols; Desipramine; Double-Blind Method; Humans; Male; Paroxetine; Reflex, Pupillary; Selective Serotonin Reuptake Inhibitors; Venlafaxine Hydrochloride	1999
Selective alteration of personality in response to noradrenergic and serotonergic antidepressant medication in depressed sample: evidence of non-specificity. Psychiatry research, 1999, Jun-30, Volume: 86, Issue:3 Topics: Adolescent; Adrenergic Uptake Inhibitors; Aged; Antidepressive Agents; Depressive Disorder, Major; Desipramine; Female; Humans; Male; Paroxetine; Personality; Personality Inventory; Selective Serotonin Reuptake Inhibitors; Sertraline; Treatment Outcome	1999
Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline- and methoxamine-evoked constriction of the dorsal hand vein. British journal of clinical pharmacology, 1999, Volume: 48, Issue:3 Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Cross-Over Studies; Cyclohexanols; Desipramine; Double-Blind Method; Drug Interactions; Hand; Heart Rate; Humans; Male; Methoxamine; Norepinephrine; Paroxetine; Salivation; Selective Serotonin Reuptake Inhibitors; Vasoconstriction; Veins; Venlafaxine Hydrochloride	1999
The effects of antidepressants on obstructed and unobstructed gait in healthy elderly people. The journals of gerontology. Series A, Biological sciences and medical sciences, 2001, Volume: 56, Issue:1 Topics: Affect; Aged; Amitriptyline; Antidepressive Agents; Desipramine; Double-Blind Method; Female; Gait; Humans; Male; Paroxetine; Psychomotor Performance; Risk Factors; Selective Serotonin Reuptake Inhibitors	2001
Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine. The American journal of psychiatry, 2002, Volume: 159, Issue:10 Topics: Adult; Ambulatory Care; Carrier Proteins; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters; Treatment Outcome	2002
Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:3 Topics: Adult; Affect; Aged; Analysis of Variance; Antidepressive Agents; Chi-Square Distribution; Depressive Disorder, Major; Desipramine; Double-Blind Method; Female; Humans; Logistic Models; Male; Middle Aged; Motor Activity; Paroxetine; Placebo Effect; Time Factors	2004
Cognitive therapy vs medications in the treatment of moderate to severe depression. Archives of general psychiatry, 2005, Volume: 62, Issue:4 Topics: Adult; Ambulatory Care; Antidepressive Agents; Cognitive Behavioral Therapy; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Humans; Lithium Carbonate; Male; Paroxetine; Placebos; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Treatment Outcome	2005
A double-blind, multicenter, parallel-group study of paroxetine, desipramine, or placebo in breast cancer patients (stages I, II, III, and IV) with major depression. The Journal of clinical psychiatry, 2006, Volume: 67, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Breast; Breast Neoplasms; Comorbidity; Depressive Disorder, Major; Desipramine; Double-Blind Method; Female; Humans; Middle Aged; Neoplasm Staging; Paroxetine; Placebos; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Treatment Outcome	2006
Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteers. The international journal of neuropsychopharmacology, 2007, Volume: 10, Issue:1 Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Blood Platelets; Blood Pressure; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Piperazines; Reference Values; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Time Factors; Triazoles; Tyramine; Venlafaxine Hydrochloride	2007
The effects of desvenlafaxine and paroxetine on the pharmacokinetics of the cytochrome P450 2D6 substrate desipramine in healthy adults. Journal of clinical pharmacology, 2009, Volume: 49, Issue:2 Topics: Adult; Antidepressive Agents; Area Under Curve; Cross-Over Studies; Cyclohexanols; Cytochrome P-450 CYP2D6 Inhibitors; Desipramine; Desvenlafaxine Succinate; Drug Interactions; Enzyme Inhibitors; Female; Genotype; Humans; Least-Squares Analysis; Male; Middle Aged; Paroxetine; United States; Young Adult	2009

Other Studies

88 other study(ies) available for paroxetine and desipramine

Article	Year
Synthesis and characterization of radioiodinated N-(3-iodopropen-1-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropanes: potential dopamine reuptake site imaging agents. Journal of medicinal chemistry, 1994, May-13, Volume: 37, Issue:10 Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tropanes	1994
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature, 2007, Nov-22, Volume: 450, Issue:7169 Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevity; Methiothepin; Mianserin; Octopamine; Receptors, Biogenic Amine; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Signal Transduction; Starvation	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors. Bioorganic & medicinal chemistry letters, 2008, Sep-15, Volume: 18, Issue:18 Topics: Humans; Indoles; Molecular Structure; Neurotransmitter Uptake Inhibitors; Norepinephrine; Stereoisomerism; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells). Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4 Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles	2013
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: autoradiographic and functional studies. Neuropharmacology, 1991, Volume: 30, Issue:6 Topics: Adrenergic beta-Antagonists; Amitriptyline; Animals; Autoradiography; Brain Chemistry; Cyclic AMP; Desipramine; Iodine Radioisotopes; Iodocyanopindolol; Kinetics; Male; Membranes; Paroxetine; Pindolol; Piperidines; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin Antagonists	1991
Serotonergic and catecholaminergic reuptake inhibitors have opposite effects on the ultrasonic isolation calls of rat pups. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1990, Volume: 3, Issue:1 Topics: Animals; Body Temperature; Catecholamines; Citalopram; Clomipramine; Desipramine; Flumazenil; Mazindol; Motor Activity; Naltrexone; Nortriptyline; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Stress, Psychological; Ultrasonics; Vocalization, Animal	1990
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment. Pharmacology & toxicology, 1988, Volume: 63, Issue:3 Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imipramine; Ketanserin; Kinetics; Male; Paroxetine; Piperidines; Prazosin; Proteins; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Time Factors	1988
Acute or chronic changes of noradrenergic transmission do not affect the alpha-adrenoceptor-mediated inhibition of 3H-serotonin release in the cerebral cortex. Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 320, Issue:1 Topics: Animals; Cerebral Cortex; Desipramine; Drug Interactions; Guanethidine; Hydroxydopamines; Male; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission	1982
Antidepressants reverse the olfactory bulbectomy-induced decreases in splenic peripheral-type benzodiazepine receptors in rats. European journal of pharmacology, 1995, Jan-16, Volume: 272, Issue:2-3 Topics: Animals; Antidepressive Agents; Clorgyline; Desipramine; Immune Tolerance; Isoquinolines; Male; Olfactory Bulb; Organ Size; Paroxetine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Serotonin; Spleen; Thymus Gland	1995
Effect of chronic administration of selective 5-hydroxytryptamine and noradrenaline uptake inhibitors on a putative index of 5-HT2C/2B receptor function. Neuropharmacology, 1994, Volume: 33, Issue:12 Topics: Animals; Brain; Clomipramine; Desipramine; Fluoxetine; Male; Motor Activity; Norepinephrine; Paroxetine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Time Factors	1994
Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants. Journal of clinical psychopharmacology, 1995, Volume: 15, Issue:2 Topics: Alprazolam; Biotransformation; Culture Techniques; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Dose-Response Relationship, Drug; Fluvoxamine; Humans; Hydroxylation; Microsomes, Liver; Mixed Function Oxygenases; Paroxetine; Selective Serotonin Reuptake Inhibitors	1995
Antidepressant-induced modulation of GABAA receptors and beta-adrenoceptors but not GABAB receptors in the frontal cortex of olfactory bulbectomised rats. European journal of pharmacology, 1994, Sep-01, Volume: 262, Issue:1-2 Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Antidepressive Agents; Binding Sites; Clorgyline; Desipramine; Down-Regulation; Frontal Lobe; Infusion Pumps, Implantable; Male; Olfactory Bulb; Paroxetine; Propanolamines; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, GABA-A; Receptors, GABA-B	1994
Platelet 5-HT uptake sites in depression: three concurrent measures using [3H] imipramine and [3H] paroxetine. Psychopharmacology, 1993, Volume: 110, Issue:1-2 Topics: Adult; Biomarkers; Blood Platelets; Cell Membrane; Citalopram; Depressive Disorder; Desipramine; Female; Humans; Imipramine; In Vitro Techniques; Male; Middle Aged; Paroxetine; Receptors, Serotonin; Sodium	1993
Platelet 3H-paroxetine binding in control subjects and depressed patients: relationship to serotonin uptake and age. Psychiatry research, 1994, Volume: 51, Issue:2 Topics: Adult; Age Factors; Binding Sites; Blood Platelets; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Imipramine; Infant; Male; Paroxetine; Serotonin	1994
The effect of 5-HT receptor ligands on the uptake of [3H]5-hydroxytryptamine into rat cortical synaptosomes. European journal of pharmacology, 1993, Aug-03, Volume: 239, Issue:1-3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Cocaine; Desipramine; Female; Fluoxetine; In Vitro Techniques; Indoles; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperazines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptosomes; Tropisetron	1993
2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neuro The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cerebral Cortex; Clorgyline; Desipramine; Fluoxetine; Hippocampus; Male; Mice; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurotransmitter Uptake Inhibitors; Norepinephrine; Paroxetine; Selegiline; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Time Factors	1993
A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:1 Topics: Animals; Binding Sites; Brain; Carbon Radioisotopes; Desipramine; Isoquinolines; Mice; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Tomography, Emission-Computed	1993
Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine. European journal of clinical pharmacology, 1993, Volume: 44, Issue:4 Topics: Administration, Oral; Adult; Biotransformation; Desipramine; Drug Interactions; Humans; Male; Models, Biological; Paroxetine; Reference Values; Sparteine	1993
Pharmacokinetics of the newer antidepressants. The American journal of medicine, 1996, Volume: 100, Issue:1 Topics: 1-Naphthylamine; Antidepressive Agents, Second-Generation; Desipramine; Fluoxetine; Humans; Isoenzymes; Liver; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline	1996
Drug-drug interactions. The Journal of clinical psychiatry, 1996, Volume: 57, Issue:5 Topics: 1-Naphthylamine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Mixed Function Oxygenases; Paroxetine; Research Design; Selective Serotonin Reuptake Inhibitors; Sertraline	1996
Paroxetine shifts imipramine metabolism. Psychiatry research, 1996, Jan-31, Volume: 59, Issue:3 Topics: Adult; Antidepressive Agents, Tricyclic; Cytochrome P-450 Enzyme System; Depressive Disorder; Desipramine; Drug Synergism; Humans; Imipramine; Male; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors	1996
The effect of the potassium channel activator, cromakalim, on antidepressant drugs in the forced swimming test in mice. Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:6 Topics: Amitriptyline; Animals; Antidepressive Agents; Benzopyrans; Cromakalim; Desipramine; Drug Interactions; Imipramine; Locomotion; Male; Mianserin; Mice; Minoxidil; Paroxetine; Physical Exertion; Potassium Channels; Pyrroles; Swimming	1996
Withdrawal hypomania associated with paroxetine. Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:1 Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Panic Disorder; Paroxetine; Substance Withdrawal Syndrome	1997
N-substituted phenyltropanes as in vivo binding ligands for rapid imaging studies of the dopamine transporter. Synapse (New York, N.Y.), 1997, Volume: 25, Issue:4 Topics: Analysis of Variance; Animals; Binding, Competitive; Brain; Carrier Proteins; Cerebellum; Cocaine; Corpus Striatum; Desipramine; Dopamine Plasma Membrane Transport Proteins; Iodine Radioisotopes; Kinetics; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Radioligand Assay; Rats; Structure-Activity Relationship; Symporters	1997
RTI-352: a 3 alpha analogue of RTI-55 as an in vivo dopamine transporter binding ligand. Synapse (New York, N.Y.), 1997, Volume: 25, Issue:4 Topics: Animals; Brain; Carrier Proteins; Cocaine; Desipramine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Kinetics; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Organ Specificity; Paroxetine; Piperazines; Tritium	1997
Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2. British journal of clinical pharmacology, 1997, Volume: 43, Issue:6 Topics: 1-Naphthylamine; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cyclohexanols; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Fluoxetine; Fluvoxamine; Frozen Sections; Humans; Hydroxylation; Imipramine; In Vitro Techniques; Lethal Dose 50; Microsomes, Liver; Mixed Function Oxygenases; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Venlafaxine Hydrochloride	1997
Individual differences in response to imipramine in the mouse tail suspension test. Psychopharmacology, 1997, Volume: 134, Issue:4 Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Desipramine; Disease Models, Animal; Imipramine; Individuality; Male; Mice; Mice, Inbred Strains; Motor Activity; Paroxetine; Restraint, Physical	1997
Distribution of paroxetine in three postmortem cases. Journal of analytical toxicology, 1998, Volume: 22, Issue:6 Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Drug Interactions; Drug Overdose; Fatal Outcome; Female; Humans; Imipramine; Male; Middle Aged; Paroxetine; Suicide; Tissue Distribution	1998
Blockade of 5-hydroxytryptamine and noradrenaline uptake by venlafaxine: a comparative study with paroxetine and desipramine. British journal of pharmacology, 1998, Volume: 125, Issue:3 Topics: Adrenergic Uptake Inhibitors; Animals; Cyclohexanols; Depression; Desipramine; Hippocampus; Injections, Intravenous; Iontophoresis; Male; Norepinephrine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Venlafaxine Hydrochloride	1998
Discrepancies between the in vitro and in vivo 5-HT and norepinephrine re-uptake blocking properties of venlafaxine. Annals of the New York Academy of Sciences, 1998, Dec-15, Volume: 861 Topics: Animals; Brain; Cyclohexanols; Desipramine; In Vitro Techniques; Neurons; Norepinephrine; Paroxetine; Raphe Nuclei; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Synapses; Venlafaxine Hydrochloride	1998
Venlafaxine: discrepancy between in vivo 5-HT and NE reuptake blockade and affinity for reuptake sites. Synapse (New York, N.Y.), 1999, Jun-01, Volume: 32, Issue:3 Topics: Action Potentials; Adrenergic Uptake Inhibitors; Animals; Binding Sites; Cyclohexanols; Desipramine; Fenfluramine; Hippocampus; In Vitro Techniques; Locus Coeruleus; Male; Neurons; Norepinephrine; Paroxetine; Piperazines; Piperoxan; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Tyramine; Venlafaxine Hydrochloride	1999
Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo: effect of chronic antidepressant drug treatment. British journal of pharmacology, 1999, Volume: 126, Issue:8 Topics: Adrenergic Uptake Inhibitors; Animals; Autoreceptors; Circadian Rhythm; Desipramine; Hypothalamus, Anterior; Indoles; Male; Methiothepin; Microdialysis; Paroxetine; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists	1999
Molecular cloning, expression and characterization of a bovine serotonin transporter. Brain research. Molecular brain research, 1999, Jul-23, Volume: 71, Issue:1 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Citalopram; Cloning, Molecular; Desipramine; Female; Fluoxetine; HeLa Cells; Humans; Imipramine; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Organ Specificity; Paroxetine; Phylogeny; Pregnancy; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transfection	1999
Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones. Journal of neuroendocrinology, 1999, Volume: 11, Issue:11 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cells, Cultured; Desipramine; Dexamethasone; Gene Expression Regulation; Haloperidol; Hippocampus; Ketanserin; Mianserin; Neurons; Paroxetine; Phentolamine; Propranolol; Radioligand Assay; Rats; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; Sulpiride; Transcription, Genetic; Tritium	1999
Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Dec-01, Volume: 19, Issue:23 Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Carrier Proteins; Desipramine; Fluvoxamine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Paroxetine; Phenelzine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sertraline; Time Factors	1999
Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat. Life sciences, 1999, Volume: 65, Issue:17 Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Body Weight; Cyclohexanols; Desipramine; Drinking Behavior; Eating; Endotoxins; Escherichia coli; Interleukin-10; Lipopolysaccharides; Male; Motor Activity; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tumor Necrosis Factor-alpha; Venlafaxine Hydrochloride	1999
Lack of desipramine toxicity with citalopram. The Journal of clinical psychiatry, 2000, Volume: 61, Issue:2 Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Cytochrome P-450 CYP2D6; Depressive Disorder; Desipramine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Liver; Middle Aged; Paroxetine	2000
Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test. Pharmacology, biochemistry, and behavior, 2000, Volume: 65, Issue:4 Topics: Amygdala; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Biogenic Amines; Brain Chemistry; Cerebral Cortex; Corticosterone; Cyclohexanols; Depressive Disorder; Desipramine; Hormones; Hypothalamo-Hypophyseal System; Male; Motor Activity; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Swimming; Venlafaxine Hydrochloride	2000
Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine. European journal of pharmacology, 2000, Oct-27, Volume: 407, Issue:1-2 Topics: Adrenergic Uptake Inhibitors; Animals; Desipramine; Hippocampus; Male; Microdialysis; Norepinephrine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin	2000
Association between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens. Psychopharmacology, 2001, Volume: 155, Issue:4 Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depression; Desipramine; Dopamine; Extracellular Space; Male; Microdialysis; Nucleus Accumbens; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Swimming	2001
Effects of Hypericum perforatum (St. John's wort) on passive avoidance in the rat: evaluation of potential neurochemical mechanisms underlying its antidepressant activity. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Avoidance Learning; Behavior, Animal; Brain Chemistry; Desipramine; Hypericum; Imipramine; Male; Muscarinic Antagonists; Norepinephrine; Paroxetine; Plant Extracts; Rats; Rats, Sprague-Dawley; Scopolamine; Serotonin	2001
Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study. Journal of psychopharmacology (Oxford, England), 2002, Volume: 16, Issue:4 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Fluoxetine; Male; Microdialysis; Norepinephrine; Paroxetine; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Venlafaxine Hydrochloride	2002
Chronic antidepressant treatment increases the membrane expression of AMPA receptors in rat hippocampus. Neuropharmacology, 2002, Volume: 43, Issue:8 Topics: Animals; Antidepressive Agents; Cell Membrane; Desipramine; Hippocampus; Male; Paroxetine; Rats; Rats, Wistar; Receptors, AMPA	2002
Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers. Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:3 Topics: Adult; Antidepressive Agents, Tricyclic; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Desipramine; Drug Administration Schedule; Drug Interactions; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Paroxetine; Reference Values; Selective Serotonin Reuptake Inhibitors; Thiophenes	2003
Antidepressant-like effects in various mice strains in the tail suspension test. Behavioural brain research, 2003, Aug-14, Volume: 143, Issue:2 Topics: Analysis of Variance; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Bupropion; Citalopram; Depression; Desipramine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hindlimb Suspension; Imipramine; Male; Mice; Mice, Inbred Strains; Paroxetine; Selective Serotonin Reuptake Inhibitors; Species Specificity	2003
Antidepressant drug treatment induces Arc gene expression in the rat brain. Neuroscience, 2003, Volume: 121, Issue:4 Topics: Animals; Antidepressive Agents; Brain; Chlorpromazine; Cyclohexanols; Cytoskeletal Proteins; Desipramine; Gene Expression; Male; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Neuronal Plasticity; Paroxetine; Prosencephalon; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission; Tranylcypromine; Up-Regulation; Venlafaxine Hydrochloride	2003
Regulation of the norepinephrine transporter by chronic administration of antidepressants. Biological psychiatry, 2004, Feb-01, Volume: 55, Issue:3 Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Autoradiography; Brain; Cerebral Cortex; Desipramine; Fluoxetine; Hippocampus; In Situ Hybridization; Locus Coeruleus; Male; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Symporters	2004
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2004, May-25, Volume: 101, Issue:21 Topics: Animals; Antidepressive Agents; Citalopram; Depression; Desipramine; Dopamine beta-Hydroxylase; Droxidopa; Fluoxetine; Gene Deletion; Mice; Morpholines; Norepinephrine; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Tail	2004
'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam. Behavioural pharmacology, 2004, Volume: 15, Issue:3 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Compulsive Behavior; Conditioning, Operant; Desipramine; Diazepam; Dose-Response Relationship, Drug; Extinction, Psychological; Fluvoxamine; Male; Paroxetine; Rats; Rats, Wistar; Reward; Selective Serotonin Reuptake Inhibitors	2004
Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice. European journal of pharmacology, 2004, Sep-19, Volume: 499, Issue:1-2 Topics: Animals; Antidepressive Agents; Clorgyline; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Hindlimb Suspension; Male; Mice; Morpholines; Motor Activity; Paroxetine; Pyrazoles; Pyrimidines; Pyrroles; Reboxetine; Receptors, Corticotropin-Releasing Hormone; Selegiline; Swimming; Tranylcypromine; Triazines	2004
Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment. Journal of neurochemistry, 2005, Volume: 94, Issue:4 Topics: Amino Acid Transport Systems, Acidic; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Desipramine; Electroshock; Fluoxetine; Male; Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2; Vesicular Glutamate Transport Proteins	2005
A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biological psychiatry, 2006, Mar-01, Volume: 59, Issue:5 Topics: Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Brain; Cyclohexanols; Desipramine; Male; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Venlafaxine Hydrochloride	2006
Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment. Neuropharmacology, 2005, Volume: 49, Issue:8 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Autoradiography; Blotting, Western; Brain-Derived Neurotrophic Factor; Desipramine; Disks Large Homolog 4 Protein; Hippocampus; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Paroxetine; Rats; Rats, Wistar; Receptors, AMPA; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Synapses; Tubulin	2005
Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells. Biochemical pharmacology, 2005, Nov-01, Volume: 70, Issue:9 Topics: Adrenal Medulla; Adrenergic Uptake Inhibitors; Animals; Cattle; Cells, Cultured; Cycloheximide; Cyclopropanes; Dactinomycin; Desipramine; Gene Expression Regulation; Milnacipran; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; RNA, Messenger; Up-Regulation	2005
Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain. Biological psychiatry, 2007, Jan-15, Volume: 61, Issue:2 Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Autoradiography; Brain; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Male; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Thiophenes	2007
Effect of antidepressant drugs on 6-OHDA-treated mice in the FST. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2007, Volume: 17, Issue:3 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Cerebral Cortex; Citalopram; Depression; Desipramine; Dopamine Uptake Inhibitors; Hippocampus; Hypothalamus; Imipramine; Injections, Intraventricular; Male; Mice; Neostriatum; Oxidopamine; Paroxetine; Swimming	2007
Antidepressant-like activity of selective serotonin reuptake inhibitors combined with a NK1 receptor antagonist in the mouse forced swimming test. Behavioural brain research, 2006, Sep-25, Volume: 172, Issue:2 Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antidepressive Agents; Citalopram; Depressive Disorder; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Escape Reaction; Male; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Swimming; Tetrazoles	2006
Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition. Neuropharmacology, 2006, Volume: 51, Issue:7-8 Topics: Adrenergic Uptake Inhibitors; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Chemistry; Carrageenan; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Duloxetine Hydrochloride; Edema; Fluoxetine; Hot Temperature; Hyperalgesia; Male; Norepinephrine; Paroxetine; Pressure; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline; Thiophenes; Venlafaxine Hydrochloride	2006
Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze. Behavioural brain research, 2007, Jan-25, Volume: 176, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Animal; Desipramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Male; Maze Learning; Paroxetine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors	2007
Resolving the onset of antidepressants' clinical actions: critical for clinical practice and new drug development. Journal of clinical psychopharmacology, 2006, Volume: 26, Issue:6 Topics: Affect; Animals; Antidepressive Agents; Clinical Trials as Topic; Depression; Desipramine; Drug Design; Hostility; Humans; Motor Activity; Paroxetine; Psychiatric Status Rating Scales; Severity of Illness Index; Time Factors; Treatment Outcome	2006
Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs. Biochemical and biophysical research communications, 2007, Feb-16, Volume: 353, Issue:3 Topics: Animals; Antidepressive Agents; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Desipramine; Hippocampus; Male; Neuronal Plasticity; Paroxetine; Protein Subunits; Protein Transport; Rats; Rats, Wistar; Receptors, AMPA; Synapses	2007
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants. Psychopharmacology, 2007, Volume: 195, Issue:1 Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drugs, Investigational; Fluoxetine; Guinea Pigs; Injections, Intraperitoneal; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Swimming; Tranylcypromine	2007
Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models. Behavioural pharmacology, 2008, Volume: 19, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Behavior, Animal; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Exploratory Behavior; Fluoxetine; Hindlimb Suspension; Male; Maze Learning; Mice; Motor Activity; Olfactory Bulb; Ondansetron; Paroxetine; Rats; Rats, Wistar; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Stress, Psychological; Venlafaxine Hydrochloride	2008
Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission. European journal of pharmacology, 2008, Oct-10, Volume: 594, Issue:1-3 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Binding, Competitive; Cell Proliferation; Citalopram; Dentate Gyrus; Desipramine; Hippocampus; Insulin-Like Growth Factor I; Male; Nerve Growth Factors; Paroxetine; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Swimming; Synaptic Transmission; Tryptophan Hydroxylase	2008
Early prediction of the effectiveness of antidepressants: inputs from an animal model. Journal of molecular neuroscience : MN, 2009, Volume: 39, Issue:1-2 Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Desipramine; Dopamine Agents; Female; Humans; Male; Models, Animal; Motor Activity; Paroxetine; Rats; Rats, Sprague-Dawley; Treatment Outcome	2009
Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line. Neuroscience research, 2009, Volume: 64, Issue:3 Topics: Adenosine Deaminase; Amitriptyline; Amyotrophic Lateral Sclerosis; Antidepressive Agents; Arginine; Cyclopropanes; Desipramine; Fluoxetine; Fluvoxamine; Glutamine; HeLa Cells; Humans; Imipramine; Milnacipran; Morpholines; Paroxetine; Reboxetine; Receptors, AMPA; RNA Editing; RNA-Binding Proteins; RNA, Messenger	2009
[The delayed sensitization of CRH response developed after chronic variable stress on the acoustic startle reflex]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2011, Volume: 31, Issue:1 Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Corticotropin-Releasing Hormone; Desipramine; Male; Maprotiline; Norepinephrine; Paroxetine; Rats; Rats, Wistar; Receptors, Corticotropin; Reflex, Acoustic; Reflex, Startle; Stress, Psychological; Time Factors	2011
Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology, 2012, Volume: 62, Issue:1 Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Anxiety; Corticosterone; Corticotropin-Releasing Hormone; Dark Adaptation; Desipramine; Disease Models, Animal; Exploratory Behavior; Fever; Food Deprivation; Hypothalamo-Hypophyseal System; Magnesium; Magnesium Deficiency; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Paroxetine; Pituitary-Adrenal System; Protein Precursors; Proto-Oncogene Proteins c-fos; Radioimmunoassay; Reaction Time; RNA, Messenger; Stress, Psychological	2012
Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus. Progress in neuro-psychopharmacology & biological psychiatry, 2014, Jan-03, Volume: 48 Topics: ADAM Proteins; ADAMTS1 Protein; Analysis of Variance; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Electroshock; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Male; Paroxetine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Thrombin; Thrombospondin 1; Time Factors	2014
Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice. Behavioural pharmacology, 2015, Volume: 26, Issue:7 Spec No Topics: Animals; Animals, Outbred Strains; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Desipramine; Duloxetine Hydrochloride; Fluvoxamine; Hydroxycorticosteroids; Idazoxan; Indoles; Male; Mice; Motor Activity; Neuropsychological Tests; Oxazines; Paroxetine; Piperazines; Psychotropic Drugs; Pyridines; Risperidone; Ritanserin; Social Behavior; Social Isolation; Sulfonamides; Venlafaxine Hydrochloride	2015
Effects of antidepressants on P2X7 receptors. Psychiatry research, 2016, Aug-30, Volume: 242 Topics: Adenosine Triphosphate; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; HEK293 Cells; Humans; Paroxetine; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Rats; Receptors, Purinergic P2X7	2016
Influence of the selective antagonist of the NR2B subunit of the NMDA receptor, traxoprodil, on the antidepressant-like activity of desipramine, paroxetine, milnacipran, and bupropion in mice. Journal of neural transmission (Vienna, Austria : 1996), 2017, Volume: 124, Issue:3 Topics: Analysis of Variance; Animals; Antidepressive Agents; Brain; Bupropion; Chromatography, High Pressure Liquid; Cyclopropanes; Depressive Disorder; Desipramine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Male; Mice; Milnacipran; Motor Activity; Paroxetine; Piperidines; Receptors, N-Methyl-D-Aspartate	2017
Effect of antidepressant drugs on the brain sphingolipid system. Journal of psychopharmacology (Oxford, England), 2020, Volume: 34, Issue:7 Topics: Acid Ceramidase; Adrenergic Uptake Inhibitors; Animals; Brain; Depressive Disorder, Major; Desipramine; Disease Models, Animal; Male; Mice; Paroxetine; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Selective Serotonin Reuptake Inhibitors; Sphingolipids; Sphingomyelin Phosphodiesterase	2020