paroxetine has been researched along with desipramine in 111 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (1.80) | 18.7374 |
1990's | 37 (33.33) | 18.2507 |
2000's | 48 (43.24) | 29.6817 |
2010's | 21 (18.92) | 24.3611 |
2020's | 3 (2.70) | 2.80 |
Authors | Studies |
---|---|
Goodman, MM; Kabalka, GW; Kung, HF; Kung, MP; Switzer, R | 1 |
Topliss, JG; Yoshida, F | 1 |
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
Dansette, PM; Fontana, E; Poli, SM | 1 |
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
Buck, LB; Petrascheck, M; Ye, X | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Alfinito, P; Bray, J; Cohn, ST; Deecher, DC; Fensome, A; Johnston, G; Koury, E; Mahaney, PE; Marella, MA; McComas, CC; Nogle, L; Trybulski, EJ; Vu, AT; Ye, F; Zhang, P | 1 |
Ahman, M; Holmén, AG; Wan, H | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP | 1 |
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C | 1 |
Dalvie, D; Loi, CM; Smith, DA | 1 |
Bellman, K; Knegtel, RM; Settimo, L | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
Bowery, NG; Johnson, AM; Nelson, DR; Palmer, KJ; Pratt, GD | 1 |
Insel, TR; Winslow, JT | 1 |
Brøsen, K; Eshøj, O; Gram, LF; Mogensen, EF; Sindrup, SH | 1 |
Brunello, N; Galimberti, R; Racagni, G; Riva, M; Rovescalli, AC | 1 |
Clausing, R; Göthert, M; Schlicker, E | 1 |
Beauchemin, V; Dennis, T; Lavoie, N | 2 |
Blackburn, TP; de Biasi, V; Kennett, GA; Lightowler, S; Stevens, NC; Tulloch, IF; Wood, MD | 1 |
Court, MH; Duan, SX; Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL | 1 |
Falkowski, J; Horton, RW; Jacobson, RR; Lawrence, KM | 1 |
Asai, K; Mori, H; Nankai, M; Toru, M; Watanabe, A; Yamada, S; Yoshimoto, S | 1 |
Cheng, CH; Costall, B; Naylor, RJ; Rudd, JA | 1 |
Andrews, AM; Murphy, DL | 1 |
Dannals, RF; Ravert, HT; Ricaurte, GA; Scheffel, U; Suehiro, M; Wagner, HN | 1 |
Brøsen, K; Gram, LF; Hansen, JG; Nielsen, KK; Sindrup, SH | 1 |
Burke, MJ; Harvey, AT; Preskorn, SH | 1 |
Preskorn, SH | 1 |
Albers, LJ; Helmeste, D; Reist, C; Tang, SW; Vu, R | 1 |
Bourin, M; Pinot, P; Redrobe, JP | 1 |
Landry, P; Roy, L | 1 |
Abraham, P; Carroll, FI; Kopajtic, T; Kuhar, MJ; Lever, JR; Mathews, WB; Parham, KR; Scheffel, U | 1 |
Carroll, FI; Holmquist, CR; Kepler, JA; Kuhar, MJ; Saindane, AM; Scheffel, U; Taylor, GF; Zhan, Y | 1 |
Ahern, D; Ball, SE; Kao, J; Scatina, J | 1 |
Alderman, J; Allison, J; Chung, M; Greenblatt, DJ; Harrison, W; Penenberg, D; Preskorn, SH | 1 |
Bagby, RM; Dickens, SE; Joffe, R; Kennedy, SH; Levitt, A; Minifie, CE; Schuller, DR | 1 |
Costentin, J; Passera, G; Vaugeois, JM; Zuccaro, F | 1 |
Vermeulen, T | 1 |
Béïque, JC; Blier, P; de Montigny, C; Debonnel, G | 3 |
Bitsios, P; Bradshaw, CM; Szabadi, E | 1 |
Hannon, SD; Martin, KF; Redfern, PH; Sayer, TJ | 1 |
Kristensen, AS; Mortensen, OV; Rudnick, G; Wiborg, O | 1 |
Bagby, RM; Joffe, RT; Kennedy, SH; Levitan, RD; Levitt, AJ | 1 |
Abdelmawla, AH; Bradshaw, CM; Langley, RW; Szabadi, E | 1 |
Fujiseki, Y; Inagaki, C; Kinoshita, T; Okugawa, G; Omori, K; Suzukawa, J | 1 |
Benmansour, S; Cecchi, M; Frazer, A; Gerhardt, GA; Gould, GG; Javors, MA; Morilak, DA | 1 |
Connor, TJ; Kelly, JP; Leonard, BE; Nolan, Y; Shen, Y | 1 |
Ashton, AK | 1 |
Connor, TJ; Harkin, A; Kelliher, P; Kelly, JP; Leonard, BE; Shen, Y | 1 |
Hajós-Korcsok, E; McTavish, SF; Sharp, T | 1 |
Draganich, LF; Karrison, T; Klafta, J; Zacny, J | 1 |
Nakash, R; Overstreet, DH; Yadid, G; Zangen, A | 1 |
Misane, I; Ogren, SO | 1 |
Gilmor, ML; Nemeroff, CB; Owens, MJ | 1 |
Beyer, CE; Boikess, S; Dawson, LA; Luo, B | 1 |
Del Río, J; Frechilla, D; Martinez-Turrillas, R | 3 |
Ayan-Oshodi, M; Gonzales, CR; Knadler, MP; Kuan, HY; Lim, M; Pan, A; Reddy, S; Sathirakul, K; Skinner, MH; Wise, SD; Yeo, KP | 1 |
Bourin, M; Dailly, E; David, DJ; Hascoët, M; Ripoll, N | 1 |
Pei, Q; Sharp, T; Sprakes, M; Tordera, R; Zetterström, TS | 1 |
Berman, N; Bowden, CL; Brannan, S; Frazer, A; Houston, JP; Katz, MM; Tekell, JL | 1 |
Altamirano, AV; Benmansour, S; Frazer, A; Gould, GG; Jones, DJ; Morilak, DA; Pardon, MC; Sanchez, TA | 1 |
Cryan, JF; Dalvi, A; Friedland, JC; Hirsch, BR; Jin, SH; Lucki, I; O'Leary, OF; Ouyang, M; Page, ME; Thomas, SA | 1 |
Ben-Amir, E; Doljansky, J; Flaisher, S; Joel, D | 1 |
Carey, GJ; Gold, LH; Nielsen, DM | 1 |
Amsterdam, JD; Brown, LL; DeRubeis, RJ; Gallop, R; Gladis, MM; Hollon, SD; Lovett, ML; O'Reardon, JP; Salomon, RM; Shelton, RC; Young, PR | 1 |
Pei, Q; Sharp, T; Tordera, RM | 1 |
Altamirano, AV; Frazer, A; Gould, GG; Javors, MA | 1 |
Nakamura, J; Shinkai, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N; Yoshimura, R | 1 |
Evans, DL; Goodkin, R; Guo, Y; Lawson, D; Lawson, K; Lewison, B; Manatunga, AK; Musselman, DL; Nemeroff, CB; Penna, S; Porter, M; Somerset, WI | 1 |
Frazer, A; Gould, GG; Javors, MA | 1 |
Blier, P; de Montigny, C; Debonnel, G; Hébert, C; Lavoie, N; Saint-André, E | 1 |
Bourin, M; Chenu, F; Dailly, E | 1 |
Bourin, M; Chenu, F; Gardier, AM; Guiard, BP | 1 |
Eastwood, BJ; Jones, CK; Need, AB; Shannon, HE | 1 |
Allain, H; Bentué-Ferrer, D; Bourin, M; Drapier, D; Laviolle, B; Millet, B; Reymann, JM | 1 |
Berman, N; Bowden, CL; Frazer, A; Katz, MM | 1 |
Gross, G; Groth, I; Jongen-Relo, A; Rex, A; Wicke, KM | 1 |
Borah, M; Radhakrishnan, M; Ramamoorthy, R | 1 |
Crowley, JJ; Hill, TI; Hoshaw, BA; Khawaja, X; Lucki, I; Malberg, JE; Rosenzweig-Lipson, S; Schechter, LE | 1 |
Ahmed, S; Fatato, P; Isler, JA; Jiang, Q; Nichols, AI; Patroneva, A; Paul, J; Pedersen, RD; Shenouda, M | 1 |
Guico-Pabia, CJ; Helzner, EC; Nichols, AI; Patroneva, AL; Paul, J; Preskorn, SH | 1 |
Friedman, A; Lax, E; Lubin, N; Merenlender, A; Rosenstein, M; Yadid, G | 1 |
Bekkering, GE; Tuinier, S; Verbeeck, W | 1 |
Aburakawa, Y; Aizawa, H; Hasebe, N; Kwak, S; Sawada, J; Yamashita, T | 1 |
De Keyser, J; Glazenborg, A; Koch, MW; Mostert, J; Uyttenboogaart, M | 1 |
Asakura, M; Fujiwara, K; Kanai, S; Nakano, M; Osada, K; Sasuga, Y; Tanaka, D; Yanagida, T | 1 |
Hetzenauer, A; Sartori, SB; Singewald, N; Whittle, N | 1 |
Hisaoka-Nakashima, K; Kajitani, N; Morinobu, S; Okada-Tsuchioka, M; Segawa, M; Shibasaki, C; Takebayashi, M | 1 |
Akindipe, TO; Ipser, JC; Sager, C; Stein, DJ; Wilson, D | 1 |
Ago, Y; Hasebe, S; Hashimoto, H; Matsuda, T; Nishiyama, S; Oka, S; Takuma, K | 1 |
Buoli, M; Cahn, W; Serati, M | 1 |
Cipriani, A; Coghill, D; Cohen, D; Cuijpers, P; Del Giovane, C; Hazell, P; Hetrick, SE; Leucht, S; Liu, L; Liu, Y; Michael, KD; Pu, J; Qin, B; Ravindran, AV; Whittington, C; Xie, P; Yang, L; Zhang, Y; Zhou, X | 1 |
Jiang, CL; Liu, WZ; Shang, ZL; Wang, W; Xiang, ZH | 1 |
Dudka, J; Poleszak, E; Serefko, A; Stasiuk, W; Świąder, K; Szopa, A; Wlaź, P; Wyska, E | 1 |
Arroo, R; Jaddoa, E; Masania, J; Masiero, E; Sgamma, T; Sillence, D; Zetterström, T | 1 |
Arranz, B; Arrojo, M; Becoña, E; Bernardo, M; Castells, X; Cunill, R; Flórez, G; Fonseca, F; Garriga, M; Goikolea, JM; González-Pinto, A; López, A; Sáiz, PA; San, L; Tirado-Muñoz, J; Torrens, M; Zorrilla, I | 1 |
Barbui, C; Bighelli, I; Caldwell, DM; Cipriani, A; Davies, SJ; Dawson, S; Dias, S; Furukawa, TA; Guaiana, G; Imai, H; Koesters, M; Meader, N; Pompoli, A; Robertson, L; Tajika, A | 1 |
10 review(s) available for paroxetine and desipramine
Article | Year |
---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Effect of desvenlafaxine on the cytochrome P450 2D6 enzyme system.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Cytochrome P-450 CYP2D6; Depressive Disorder, Major; Desipramine; Desvenlafaxine Succinate; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Health Status; Humans; Paroxetine; Thiophenes | 2008 |
Antidepressants in the treatment of adult attention-deficit hyperactivity disorder: a systematic review.
Topics: Adrenergic Uptake Inhibitors; Adult; Age Factors; Antidepressive Agents; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Bupropion; Comorbidity; Desipramine; Evidence-Based Medicine; Humans; Lithium Carbonate; Monoamine Oxidase Inhibitors; Paroxetine; Randomized Controlled Trials as Topic; Research Design; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 2009 |
Pharmacologic treatment of depression in multiple sclerosis.
Topics: Adult; Antidepressive Agents; Depression; Desipramine; Humans; Multiple Sclerosis; Paroxetine; Randomized Controlled Trials as Topic | 2011 |
Pharmacotherapy for anxiety and comorbid alcohol use disorders.
Topics: Alcohol-Related Disorders; Anxiety; Anxiety Disorders; Buspirone; Comorbidity; Desipramine; Humans; Paroxetine; Phobia, Social; Publication Bias; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Sertraline; Stress Disorders, Post-Traumatic | 2015 |
Alternative pharmacological strategies for adult ADHD treatment: a systematic review.
Topics: Adrenergic alpha-Agonists; Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Central Nervous System Stimulants; Desipramine; Dopamine Agents; Droxidopa; Drug Combinations; Duloxetine Hydrochloride; Guanfacine; Histamine Agents; Humans; Lisdexamfetamine Dimesylate; Lithium Compounds; Lobeline; Mecamylamine; Memantine; Modafinil; Morpholines; Nicotinic Agonists; Nicotinic Antagonists; Nomifensine; Paroxetine; Pyridines; Pyridoxine; Pyrrolidonecarboxylic Acid; Quinazolinones; Reboxetine; Venlafaxine Hydrochloride; Wakefulness-Promoting Agents | 2016 |
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Confounding Factors, Epidemiologic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Evidence-Based Medicine; Fluoxetine; Humans; Imipramine; Mianserin; Mirtazapine; Nortriptyline; Paroxetine; Piperazines; Randomized Controlled Trials as Topic; Research Design; Sertraline; Treatment Outcome; Triazoles; Venlafaxine Hydrochloride | 2016 |
Clinical practice guideline on pharmacological and psychological management of adult patients with an anxiety disorder and comorbid substance use.
Topics: Adult; Anxiety Disorders; Desipramine; Humans; Naltrexone; Paroxetine; Substance-Related Disorders | 2022 |
Pharmacological treatments in panic disorder in adults: a network meta-analysis.
Topics: Adult; Alprazolam; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipramine; Clonazepam; Desipramine; Diazepam; Fluoxetine; Humans; Network Meta-Analysis; Panic Disorder; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Venlafaxine Hydrochloride | 2023 |
13 trial(s) available for paroxetine and desipramine
Article | Year |
---|---|
The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms.
Topics: Depression; Desipramine; Diabetic Neuropathies; Humans; Imipramine; Nervous System; Osmolar Concentration; Paroxetine; Piperidines; Serotonin Antagonists; Time Factors | 1990 |
Desipramine pharmacokinetics when coadministered with paroxetine or sertraline in extensive metabolizers.
Topics: 1-Naphthylamine; Adolescent; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Area Under Curve; Cross-Over Studies; Desipramine; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Humans; Male; Middle Aged; Paroxetine; Sertraline | 1997 |
Differential pharmacological treatment response in high angry hostile and low angry hostile depressed patients: a retrospective analysis.
Topics: 1-Naphthylamine; Adult; Ambulatory Care; Analysis of Variance; Anger; Cyclohexanols; Depressive Disorder; Desipramine; Female; Hostility; Humans; Male; Paroxetine; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Sertraline; Treatment Outcome; Venlafaxine Hydrochloride | 1997 |
Comparison of the effects of venlafaxine, paroxetine and desipramine on the pupillary light reflex in man.
Topics: Adrenergic Uptake Inhibitors; Adult; Cross-Over Studies; Cyclohexanols; Desipramine; Double-Blind Method; Humans; Male; Paroxetine; Reflex, Pupillary; Selective Serotonin Reuptake Inhibitors; Venlafaxine Hydrochloride | 1999 |
Selective alteration of personality in response to noradrenergic and serotonergic antidepressant medication in depressed sample: evidence of non-specificity.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Aged; Antidepressive Agents; Depressive Disorder, Major; Desipramine; Female; Humans; Male; Paroxetine; Personality; Personality Inventory; Selective Serotonin Reuptake Inhibitors; Sertraline; Treatment Outcome | 1999 |
Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline- and methoxamine-evoked constriction of the dorsal hand vein.
Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Cross-Over Studies; Cyclohexanols; Desipramine; Double-Blind Method; Drug Interactions; Hand; Heart Rate; Humans; Male; Methoxamine; Norepinephrine; Paroxetine; Salivation; Selective Serotonin Reuptake Inhibitors; Vasoconstriction; Veins; Venlafaxine Hydrochloride | 1999 |
The effects of antidepressants on obstructed and unobstructed gait in healthy elderly people.
Topics: Affect; Aged; Amitriptyline; Antidepressive Agents; Desipramine; Double-Blind Method; Female; Gait; Humans; Male; Paroxetine; Psychomotor Performance; Risk Factors; Selective Serotonin Reuptake Inhibitors | 2001 |
Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine.
Topics: Adult; Ambulatory Care; Carrier Proteins; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters; Treatment Outcome | 2002 |
Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression.
Topics: Adult; Affect; Aged; Analysis of Variance; Antidepressive Agents; Chi-Square Distribution; Depressive Disorder, Major; Desipramine; Double-Blind Method; Female; Humans; Logistic Models; Male; Middle Aged; Motor Activity; Paroxetine; Placebo Effect; Time Factors | 2004 |
Cognitive therapy vs medications in the treatment of moderate to severe depression.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Cognitive Behavioral Therapy; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Humans; Lithium Carbonate; Male; Paroxetine; Placebos; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Treatment Outcome | 2005 |
A double-blind, multicenter, parallel-group study of paroxetine, desipramine, or placebo in breast cancer patients (stages I, II, III, and IV) with major depression.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Breast; Breast Neoplasms; Comorbidity; Depressive Disorder, Major; Desipramine; Double-Blind Method; Female; Humans; Middle Aged; Neoplasm Staging; Paroxetine; Placebos; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Treatment Outcome | 2006 |
Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteers.
Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Blood Platelets; Blood Pressure; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Piperazines; Reference Values; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Time Factors; Triazoles; Tyramine; Venlafaxine Hydrochloride | 2007 |
The effects of desvenlafaxine and paroxetine on the pharmacokinetics of the cytochrome P450 2D6 substrate desipramine in healthy adults.
Topics: Adult; Antidepressive Agents; Area Under Curve; Cross-Over Studies; Cyclohexanols; Cytochrome P-450 CYP2D6 Inhibitors; Desipramine; Desvenlafaxine Succinate; Drug Interactions; Enzyme Inhibitors; Female; Genotype; Humans; Least-Squares Analysis; Male; Middle Aged; Paroxetine; United States; Young Adult | 2009 |
88 other study(ies) available for paroxetine and desipramine
Article | Year |
---|---|
Synthesis and characterization of radioiodinated N-(3-iodopropen-1-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropanes: potential dopamine reuptake site imaging agents.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tropanes | 1994 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevity; Methiothepin; Mianserin; Octopamine; Receptors, Biogenic Amine; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Signal Transduction; Starvation | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
Topics: Humans; Indoles; Molecular Structure; Neurotransmitter Uptake Inhibitors; Norepinephrine; Stereoisomerism; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Species independence in brain tissue binding using brain homogenates.
Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles | 2013 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: autoradiographic and functional studies.
Topics: Adrenergic beta-Antagonists; Amitriptyline; Animals; Autoradiography; Brain Chemistry; Cyclic AMP; Desipramine; Iodine Radioisotopes; Iodocyanopindolol; Kinetics; Male; Membranes; Paroxetine; Pindolol; Piperidines; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin Antagonists | 1991 |
Serotonergic and catecholaminergic reuptake inhibitors have opposite effects on the ultrasonic isolation calls of rat pups.
Topics: Animals; Body Temperature; Catecholamines; Citalopram; Clomipramine; Desipramine; Flumazenil; Mazindol; Motor Activity; Naltrexone; Nortriptyline; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Stress, Psychological; Ultrasonics; Vocalization, Animal | 1990 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imipramine; Ketanserin; Kinetics; Male; Paroxetine; Piperidines; Prazosin; Proteins; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Time Factors | 1988 |
Acute or chronic changes of noradrenergic transmission do not affect the alpha-adrenoceptor-mediated inhibition of 3H-serotonin release in the cerebral cortex.
Topics: Animals; Cerebral Cortex; Desipramine; Drug Interactions; Guanethidine; Hydroxydopamines; Male; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission | 1982 |
Antidepressants reverse the olfactory bulbectomy-induced decreases in splenic peripheral-type benzodiazepine receptors in rats.
Topics: Animals; Antidepressive Agents; Clorgyline; Desipramine; Immune Tolerance; Isoquinolines; Male; Olfactory Bulb; Organ Size; Paroxetine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Serotonin; Spleen; Thymus Gland | 1995 |
Effect of chronic administration of selective 5-hydroxytryptamine and noradrenaline uptake inhibitors on a putative index of 5-HT2C/2B receptor function.
Topics: Animals; Brain; Clomipramine; Desipramine; Fluoxetine; Male; Motor Activity; Norepinephrine; Paroxetine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Time Factors | 1994 |
Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants.
Topics: Alprazolam; Biotransformation; Culture Techniques; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Dose-Response Relationship, Drug; Fluvoxamine; Humans; Hydroxylation; Microsomes, Liver; Mixed Function Oxygenases; Paroxetine; Selective Serotonin Reuptake Inhibitors | 1995 |
Antidepressant-induced modulation of GABAA receptors and beta-adrenoceptors but not GABAB receptors in the frontal cortex of olfactory bulbectomised rats.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Antidepressive Agents; Binding Sites; Clorgyline; Desipramine; Down-Regulation; Frontal Lobe; Infusion Pumps, Implantable; Male; Olfactory Bulb; Paroxetine; Propanolamines; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, GABA-A; Receptors, GABA-B | 1994 |
Platelet 5-HT uptake sites in depression: three concurrent measures using [3H] imipramine and [3H] paroxetine.
Topics: Adult; Biomarkers; Blood Platelets; Cell Membrane; Citalopram; Depressive Disorder; Desipramine; Female; Humans; Imipramine; In Vitro Techniques; Male; Middle Aged; Paroxetine; Receptors, Serotonin; Sodium | 1993 |
Platelet 3H-paroxetine binding in control subjects and depressed patients: relationship to serotonin uptake and age.
Topics: Adult; Age Factors; Binding Sites; Blood Platelets; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Imipramine; Infant; Male; Paroxetine; Serotonin | 1994 |
The effect of 5-HT receptor ligands on the uptake of [3H]5-hydroxytryptamine into rat cortical synaptosomes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Cocaine; Desipramine; Female; Fluoxetine; In Vitro Techniques; Indoles; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperazines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptosomes; Tropisetron | 1993 |
2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neuro
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cerebral Cortex; Clorgyline; Desipramine; Fluoxetine; Hippocampus; Male; Mice; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurotransmitter Uptake Inhibitors; Norepinephrine; Paroxetine; Selegiline; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Time Factors | 1993 |
A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z.
Topics: Animals; Binding Sites; Brain; Carbon Radioisotopes; Desipramine; Isoquinolines; Mice; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Tomography, Emission-Computed | 1993 |
Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine.
Topics: Administration, Oral; Adult; Biotransformation; Desipramine; Drug Interactions; Humans; Male; Models, Biological; Paroxetine; Reference Values; Sparteine | 1993 |
Pharmacokinetics of the newer antidepressants.
Topics: 1-Naphthylamine; Antidepressive Agents, Second-Generation; Desipramine; Fluoxetine; Humans; Isoenzymes; Liver; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline | 1996 |
Drug-drug interactions.
Topics: 1-Naphthylamine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Mixed Function Oxygenases; Paroxetine; Research Design; Selective Serotonin Reuptake Inhibitors; Sertraline | 1996 |
Paroxetine shifts imipramine metabolism.
Topics: Adult; Antidepressive Agents, Tricyclic; Cytochrome P-450 Enzyme System; Depressive Disorder; Desipramine; Drug Synergism; Humans; Imipramine; Male; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors | 1996 |
The effect of the potassium channel activator, cromakalim, on antidepressant drugs in the forced swimming test in mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Benzopyrans; Cromakalim; Desipramine; Drug Interactions; Imipramine; Locomotion; Male; Mianserin; Mice; Minoxidil; Paroxetine; Physical Exertion; Potassium Channels; Pyrroles; Swimming | 1996 |
Withdrawal hypomania associated with paroxetine.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Panic Disorder; Paroxetine; Substance Withdrawal Syndrome | 1997 |
N-substituted phenyltropanes as in vivo binding ligands for rapid imaging studies of the dopamine transporter.
Topics: Analysis of Variance; Animals; Binding, Competitive; Brain; Carrier Proteins; Cerebellum; Cocaine; Corpus Striatum; Desipramine; Dopamine Plasma Membrane Transport Proteins; Iodine Radioisotopes; Kinetics; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Radioligand Assay; Rats; Structure-Activity Relationship; Symporters | 1997 |
RTI-352: a 3 alpha analogue of RTI-55 as an in vivo dopamine transporter binding ligand.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Desipramine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Kinetics; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Organ Specificity; Paroxetine; Piperazines; Tritium | 1997 |
Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2.
Topics: 1-Naphthylamine; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cyclohexanols; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Fluoxetine; Fluvoxamine; Frozen Sections; Humans; Hydroxylation; Imipramine; In Vitro Techniques; Lethal Dose 50; Microsomes, Liver; Mixed Function Oxygenases; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Venlafaxine Hydrochloride | 1997 |
Individual differences in response to imipramine in the mouse tail suspension test.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Desipramine; Disease Models, Animal; Imipramine; Individuality; Male; Mice; Mice, Inbred Strains; Motor Activity; Paroxetine; Restraint, Physical | 1997 |
Distribution of paroxetine in three postmortem cases.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Drug Interactions; Drug Overdose; Fatal Outcome; Female; Humans; Imipramine; Male; Middle Aged; Paroxetine; Suicide; Tissue Distribution | 1998 |
Blockade of 5-hydroxytryptamine and noradrenaline uptake by venlafaxine: a comparative study with paroxetine and desipramine.
Topics: Adrenergic Uptake Inhibitors; Animals; Cyclohexanols; Depression; Desipramine; Hippocampus; Injections, Intravenous; Iontophoresis; Male; Norepinephrine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Venlafaxine Hydrochloride | 1998 |
Discrepancies between the in vitro and in vivo 5-HT and norepinephrine re-uptake blocking properties of venlafaxine.
Topics: Animals; Brain; Cyclohexanols; Desipramine; In Vitro Techniques; Neurons; Norepinephrine; Paroxetine; Raphe Nuclei; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Synapses; Venlafaxine Hydrochloride | 1998 |
Venlafaxine: discrepancy between in vivo 5-HT and NE reuptake blockade and affinity for reuptake sites.
Topics: Action Potentials; Adrenergic Uptake Inhibitors; Animals; Binding Sites; Cyclohexanols; Desipramine; Fenfluramine; Hippocampus; In Vitro Techniques; Locus Coeruleus; Male; Neurons; Norepinephrine; Paroxetine; Piperazines; Piperoxan; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Tyramine; Venlafaxine Hydrochloride | 1999 |
Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo: effect of chronic antidepressant drug treatment.
Topics: Adrenergic Uptake Inhibitors; Animals; Autoreceptors; Circadian Rhythm; Desipramine; Hypothalamus, Anterior; Indoles; Male; Methiothepin; Microdialysis; Paroxetine; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
Molecular cloning, expression and characterization of a bovine serotonin transporter.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Citalopram; Cloning, Molecular; Desipramine; Female; Fluoxetine; HeLa Cells; Humans; Imipramine; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Organ Specificity; Paroxetine; Phylogeny; Pregnancy; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transfection | 1999 |
Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cells, Cultured; Desipramine; Dexamethasone; Gene Expression Regulation; Haloperidol; Hippocampus; Ketanserin; Mianserin; Neurons; Paroxetine; Phentolamine; Propranolol; Radioligand Assay; Rats; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; Sulpiride; Transcription, Genetic; Tritium | 1999 |
Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Carrier Proteins; Desipramine; Fluvoxamine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Paroxetine; Phenelzine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sertraline; Time Factors | 1999 |
Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Body Weight; Cyclohexanols; Desipramine; Drinking Behavior; Eating; Endotoxins; Escherichia coli; Interleukin-10; Lipopolysaccharides; Male; Motor Activity; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tumor Necrosis Factor-alpha; Venlafaxine Hydrochloride | 1999 |
Lack of desipramine toxicity with citalopram.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Cytochrome P-450 CYP2D6; Depressive Disorder; Desipramine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Liver; Middle Aged; Paroxetine | 2000 |
Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test.
Topics: Amygdala; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Biogenic Amines; Brain Chemistry; Cerebral Cortex; Corticosterone; Cyclohexanols; Depressive Disorder; Desipramine; Hormones; Hypothalamo-Hypophyseal System; Male; Motor Activity; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Swimming; Venlafaxine Hydrochloride | 2000 |
Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine.
Topics: Adrenergic Uptake Inhibitors; Animals; Desipramine; Hippocampus; Male; Microdialysis; Norepinephrine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin | 2000 |
Association between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depression; Desipramine; Dopamine; Extracellular Space; Male; Microdialysis; Nucleus Accumbens; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Swimming | 2001 |
Effects of Hypericum perforatum (St. John's wort) on passive avoidance in the rat: evaluation of potential neurochemical mechanisms underlying its antidepressant activity.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Avoidance Learning; Behavior, Animal; Brain Chemistry; Desipramine; Hypericum; Imipramine; Male; Muscarinic Antagonists; Norepinephrine; Paroxetine; Plant Extracts; Rats; Rats, Sprague-Dawley; Scopolamine; Serotonin | 2001 |
Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Fluoxetine; Male; Microdialysis; Norepinephrine; Paroxetine; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Venlafaxine Hydrochloride | 2002 |
Chronic antidepressant treatment increases the membrane expression of AMPA receptors in rat hippocampus.
Topics: Animals; Antidepressive Agents; Cell Membrane; Desipramine; Hippocampus; Male; Paroxetine; Rats; Rats, Wistar; Receptors, AMPA | 2002 |
Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers.
Topics: Adult; Antidepressive Agents, Tricyclic; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Desipramine; Drug Administration Schedule; Drug Interactions; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Paroxetine; Reference Values; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2003 |
Antidepressant-like effects in various mice strains in the tail suspension test.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Bupropion; Citalopram; Depression; Desipramine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hindlimb Suspension; Imipramine; Male; Mice; Mice, Inbred Strains; Paroxetine; Selective Serotonin Reuptake Inhibitors; Species Specificity | 2003 |
Antidepressant drug treatment induces Arc gene expression in the rat brain.
Topics: Animals; Antidepressive Agents; Brain; Chlorpromazine; Cyclohexanols; Cytoskeletal Proteins; Desipramine; Gene Expression; Male; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Neuronal Plasticity; Paroxetine; Prosencephalon; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission; Tranylcypromine; Up-Regulation; Venlafaxine Hydrochloride | 2003 |
Regulation of the norepinephrine transporter by chronic administration of antidepressants.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Autoradiography; Brain; Cerebral Cortex; Desipramine; Fluoxetine; Hippocampus; In Situ Hybridization; Locus Coeruleus; Male; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Symporters | 2004 |
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Desipramine; Dopamine beta-Hydroxylase; Droxidopa; Fluoxetine; Gene Deletion; Mice; Morpholines; Norepinephrine; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Tail | 2004 |
'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Compulsive Behavior; Conditioning, Operant; Desipramine; Diazepam; Dose-Response Relationship, Drug; Extinction, Psychological; Fluvoxamine; Male; Paroxetine; Rats; Rats, Wistar; Reward; Selective Serotonin Reuptake Inhibitors | 2004 |
Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice.
Topics: Animals; Antidepressive Agents; Clorgyline; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Hindlimb Suspension; Male; Mice; Morpholines; Motor Activity; Paroxetine; Pyrazoles; Pyrimidines; Pyrroles; Reboxetine; Receptors, Corticotropin-Releasing Hormone; Selegiline; Swimming; Tranylcypromine; Triazines | 2004 |
Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Desipramine; Electroshock; Fluoxetine; Male; Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2; Vesicular Glutamate Transport Proteins | 2005 |
A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters.
Topics: Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Brain; Cyclohexanols; Desipramine; Male; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Venlafaxine Hydrochloride | 2006 |
Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Autoradiography; Blotting, Western; Brain-Derived Neurotrophic Factor; Desipramine; Disks Large Homolog 4 Protein; Hippocampus; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Paroxetine; Rats; Rats, Wistar; Receptors, AMPA; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Synapses; Tubulin | 2005 |
Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells.
Topics: Adrenal Medulla; Adrenergic Uptake Inhibitors; Animals; Cattle; Cells, Cultured; Cycloheximide; Cyclopropanes; Dactinomycin; Desipramine; Gene Expression Regulation; Milnacipran; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; RNA, Messenger; Up-Regulation | 2005 |
Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Autoradiography; Brain; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Male; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Thiophenes | 2007 |
Effect of antidepressant drugs on 6-OHDA-treated mice in the FST.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Cerebral Cortex; Citalopram; Depression; Desipramine; Dopamine Uptake Inhibitors; Hippocampus; Hypothalamus; Imipramine; Injections, Intraventricular; Male; Mice; Neostriatum; Oxidopamine; Paroxetine; Swimming | 2007 |
Antidepressant-like activity of selective serotonin reuptake inhibitors combined with a NK1 receptor antagonist in the mouse forced swimming test.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antidepressive Agents; Citalopram; Depressive Disorder; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Escape Reaction; Male; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Swimming; Tetrazoles | 2006 |
Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition.
Topics: Adrenergic Uptake Inhibitors; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Chemistry; Carrageenan; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Duloxetine Hydrochloride; Edema; Fluoxetine; Hot Temperature; Hyperalgesia; Male; Norepinephrine; Paroxetine; Pressure; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline; Thiophenes; Venlafaxine Hydrochloride | 2006 |
Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze.
Topics: Analysis of Variance; Animals; Behavior, Animal; Desipramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Male; Maze Learning; Paroxetine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors | 2007 |
Resolving the onset of antidepressants' clinical actions: critical for clinical practice and new drug development.
Topics: Affect; Animals; Antidepressive Agents; Clinical Trials as Topic; Depression; Desipramine; Drug Design; Hostility; Humans; Motor Activity; Paroxetine; Psychiatric Status Rating Scales; Severity of Illness Index; Time Factors; Treatment Outcome | 2006 |
Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs.
Topics: Animals; Antidepressive Agents; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Desipramine; Hippocampus; Male; Neuronal Plasticity; Paroxetine; Protein Subunits; Protein Transport; Rats; Rats, Wistar; Receptors, AMPA; Synapses | 2007 |
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drugs, Investigational; Fluoxetine; Guinea Pigs; Injections, Intraperitoneal; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Swimming; Tranylcypromine | 2007 |
Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Behavior, Animal; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Exploratory Behavior; Fluoxetine; Hindlimb Suspension; Male; Maze Learning; Mice; Motor Activity; Olfactory Bulb; Ondansetron; Paroxetine; Rats; Rats, Wistar; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Stress, Psychological; Venlafaxine Hydrochloride | 2008 |
Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Binding, Competitive; Cell Proliferation; Citalopram; Dentate Gyrus; Desipramine; Hippocampus; Insulin-Like Growth Factor I; Male; Nerve Growth Factors; Paroxetine; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Swimming; Synaptic Transmission; Tryptophan Hydroxylase | 2008 |
Early prediction of the effectiveness of antidepressants: inputs from an animal model.
Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Desipramine; Dopamine Agents; Female; Humans; Male; Models, Animal; Motor Activity; Paroxetine; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2009 |
Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line.
Topics: Adenosine Deaminase; Amitriptyline; Amyotrophic Lateral Sclerosis; Antidepressive Agents; Arginine; Cyclopropanes; Desipramine; Fluoxetine; Fluvoxamine; Glutamine; HeLa Cells; Humans; Imipramine; Milnacipran; Morpholines; Paroxetine; Reboxetine; Receptors, AMPA; RNA Editing; RNA-Binding Proteins; RNA, Messenger | 2009 |
[The delayed sensitization of CRH response developed after chronic variable stress on the acoustic startle reflex].
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Corticotropin-Releasing Hormone; Desipramine; Male; Maprotiline; Norepinephrine; Paroxetine; Rats; Rats, Wistar; Receptors, Corticotropin; Reflex, Acoustic; Reflex, Startle; Stress, Psychological; Time Factors | 2011 |
Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Anxiety; Corticosterone; Corticotropin-Releasing Hormone; Dark Adaptation; Desipramine; Disease Models, Animal; Exploratory Behavior; Fever; Food Deprivation; Hypothalamo-Hypophyseal System; Magnesium; Magnesium Deficiency; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Paroxetine; Pituitary-Adrenal System; Protein Precursors; Proto-Oncogene Proteins c-fos; Radioimmunoassay; Reaction Time; RNA, Messenger; Stress, Psychological | 2012 |
Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus.
Topics: ADAM Proteins; ADAMTS1 Protein; Analysis of Variance; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Electroshock; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Male; Paroxetine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Thrombin; Thrombospondin 1; Time Factors | 2014 |
Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice.
Topics: Animals; Animals, Outbred Strains; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Desipramine; Duloxetine Hydrochloride; Fluvoxamine; Hydroxycorticosteroids; Idazoxan; Indoles; Male; Mice; Motor Activity; Neuropsychological Tests; Oxazines; Paroxetine; Piperazines; Psychotropic Drugs; Pyridines; Risperidone; Ritanserin; Social Behavior; Social Isolation; Sulfonamides; Venlafaxine Hydrochloride | 2015 |
Effects of antidepressants on P2X7 receptors.
Topics: Adenosine Triphosphate; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; HEK293 Cells; Humans; Paroxetine; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Rats; Receptors, Purinergic P2X7 | 2016 |
Influence of the selective antagonist of the NR2B subunit of the NMDA receptor, traxoprodil, on the antidepressant-like activity of desipramine, paroxetine, milnacipran, and bupropion in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Brain; Bupropion; Chromatography, High Pressure Liquid; Cyclopropanes; Depressive Disorder; Desipramine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Male; Mice; Milnacipran; Motor Activity; Paroxetine; Piperidines; Receptors, N-Methyl-D-Aspartate | 2017 |
Effect of antidepressant drugs on the brain sphingolipid system.
Topics: Acid Ceramidase; Adrenergic Uptake Inhibitors; Animals; Brain; Depressive Disorder, Major; Desipramine; Disease Models, Animal; Male; Mice; Paroxetine; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Selective Serotonin Reuptake Inhibitors; Sphingolipids; Sphingomyelin Phosphodiesterase | 2020 |