pargyline has been researched along with selegiline in 129 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (43.41) | 18.7374 |
| 1990's | 41 (31.78) | 18.2507 |
| 2000's | 21 (16.28) | 29.6817 |
| 2010's | 9 (6.98) | 24.3611 |
| 2020's | 2 (1.55) | 2.80 |
| Authors | Studies |
|---|---|
| Dudley, MW; Kane, JM; Miller, FP; Sorensen, SM | 1 |
| Toprakçí, M; Yelekçi, K | 1 |
| Ercan, A; Jayaprakash, V; Sinha, BN; Ucar, G | 1 |
| Erol, K; Gökhan-Kelekçi, N; Kendi, E; Koyunoğlu, S; Ozgen, O; Uçar, G; Yabanoğlu, S; Yelekçi, K; Yeşilada, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Bergh, JJ; Petzer, JP; Strydom, B | 1 |
| Byun, Y; Han, MH; Hong, SH; Jung, HI; Noh, M; Park, J; Park, S | 1 |
| Legoabe, LJ; Petzer, A; Petzer, JP | 1 |
| Almos, T; Edmondson, DE; Massari, ME; Rojas, RJ; Scott, R | 1 |
| Chen, J; Huang, L; Li, X; Su, T; Wang, Y; Wang, Z; Xie, S | 1 |
| Lourens, AC; Minders, C; Petzer, A; Petzer, JP | 1 |
| Mostert, S; Petzer, A; Petzer, JP | 2 |
| Legoabe, LJ; Meiring, L; Petzer, A; Petzer, JP | 1 |
| Lipper, S; Murphy, DL; Shiling, D; Slater, S | 1 |
| Felner, AE; Waldmeier, PC | 1 |
| Boulton, AA; Philips, SR | 1 |
| Duchemin, AM; Gudehithlu, KP; Hadjiconstantinou, M; Neff, NH | 1 |
| Boulton, AA; Juorio, AV; Li, XM; Paterson, IA | 1 |
| Elebring, T; Engberg, G; Nissbrandt, H | 1 |
| Greenshaw, AJ; Juorio, AV; Paterson, IA; Zhu, MY | 1 |
| Chacón, JN; Truscott, TG | 1 |
| Pai, KS; Ravindranath, V | 1 |
| Kinemuchi, H; Obata, T; Sho, S; Yamanaka, Y | 1 |
| Arbuthnott, GW; Butcher, SP; Fairbrother, IS; Kelly, JS | 1 |
| Garrett, MC; Soares-da-Silva, P | 1 |
| Susel, Z; Yarnitsky, D | 1 |
| Borbe, HO; Nickel, B; Niebch, G | 1 |
| Cocchiara, G; Colombo, M; Dostert, P; Strolin Benedetti, M | 1 |
| Clement, HW; Grote, C; Wesemann, W | 1 |
| Gramsbergen, JB; Korf, J; Sebens, JB | 1 |
| Anderson, MC; O'Carroll, AM; Phillips, JP; Tipton, KF; Tobbia, I | 1 |
| Banerjee, DK; Kelner, K; Offutt, L; Pollard, HB; Youdim, MB | 1 |
| Greenshaw, AJ; Juorio, AV; Nguyen, TV | 1 |
| Arai, Y; Kim, SK; Kinemuchi, H; Kisara, K; Satoh, N; Satoh, S; Tadano, T | 1 |
| Balsa, MD; Gómez, N; Unzeta, M | 1 |
| Kass, GE; Nicotera, P; Orrenius, S; Wright, JM | 1 |
| Higashida, H; Kojima, K; Nagatsu, T; Nakano, T; Saito, S | 1 |
| Knoll, B; Timár, J | 1 |
| Rényi, L | 1 |
| Jenner, P; Marsden, CD | 1 |
| Bretton, C; Hof, P; Ofori, S; Schorderet, M | 1 |
| Commissaris, RL; Fontana, DJ; McCauley, RB; McIntyre, IM; Oxenkrug, GF | 1 |
| Bizière, K; Kan, JP; Roncucci, R; Wermuth, CG; Worms, P | 1 |
| Finberg, JP; Youdim, MB | 1 |
| Karoum, F | 1 |
| Bures, J; Buresová, O | 1 |
| Angers, M; Nguyen, TB | 1 |
| Gibson, CJ | 1 |
| Harik, SI; Kalaria, RN | 1 |
| Fuller, RW; Heikkila, RE; Hemrick-Luecke, SK; Kindt, MV | 1 |
| Cesura, AM; Da Prada, M; Galva, MD; Imhof, R; Picotti, GB; Takacs, B | 1 |
| Grimm, LJ; Kellar, KJ; Kettler, KG; Perry, DC | 1 |
| Larsson, BS; Lindquist, NG; Lydén-Sokolowski, A | 1 |
| Marek, GJ; Seiden, LS | 1 |
| Greenshaw, AJ; Juorio, AV; Wishart, TB | 1 |
| Cohen, G; Mytilineou, C | 1 |
| Reimherr, FW; Wender, PH; Wood, DR | 1 |
| Bocchetta, A; Corsini, GU; Del Zompo, M; Piccardi, MP; Pintus, S | 1 |
| DuMontier, G; Jeng, I; Soblosky, JS | 1 |
| Duvoisin, RC; Finberg, JP; Heikkila, RE; Youdim, MB | 1 |
| Carmichael, SW; Pfeiffer, GL | 1 |
| Colpaert, FC; Janssen, PA; Niemegeers, CJ | 1 |
| Callingham, BA; Fowler, CJ; Oreland, L | 1 |
| de Vlaming, VL; Figueroa, HR; Hall, TR; Olcese, JM | 1 |
| Green, AL | 1 |
| Chadwick, A; Hall, TR; Harvey, S | 1 |
| Barbaccia, ML; Costa, E; Gandolfi, O; Knoll, J; Zsilla, G | 1 |
| Dènes, B; Greeff, K; Tawfik, H | 2 |
| Cohen, RM; Garrick, NA; Karoum, F; Linnoila, M; Murphy, DL; Roy, B; Siever, LJ; Wyatt, RJ | 1 |
| Lenzen, S; Nahrstedt, H; Panten, U | 1 |
| Castagnoli, N; Chiba, K; Trevor, A | 1 |
| Ohishi, N; Sato, M; Yagi, K | 1 |
| Cohen, B; Cohen, G; Leist, A; Mytilineou, C; Pasik, P; Yahr, MD | 1 |
| Buckholtz, NS; Sparks, DL | 1 |
| Katsumata, Y; Matsumoto, T; Oya, M; Stepita-Klauco, M; Suzuki, O | 1 |
| Garrick, NA; Murphy, DL | 1 |
| Yu, PH | 1 |
| Coutts, RT; Foster, BC; Pasutto, FM | 1 |
| Egashira, T; Kuroiwa, Y; Yamamoto, T; Yamanaka, Y | 1 |
| Fowler, CJ; Mantle, TJ; Tipton, KF | 1 |
| Bocchinfuso, R; Khalil, A; Robinson, JB | 1 |
| Ichikawa, Y; Wu, RF | 1 |
| Cabanillas, AM; Coleoni, AH; Costamagna, ME; Masini-Repiso, AM; Pellizas, C | 1 |
| Møller, J; Nedergaard, OA | 1 |
| Bongrani, S; Dall'Olio, R; Gandolfi, O; Rimondini, R; Valsecchi, B | 1 |
| Chiueh, CC; Huang, SJ; Murphy, DL | 1 |
| Gaál, J; Kardos, V; Kollár, E; Pátfalusi, M; Patthy, M; Singer, J; Solti, M; Sziráki, I | 1 |
| Lai, CT; Yu, PH; Zuo, DM | 1 |
| Holland, DP; Ju, WY; Kwan, M; Tai, C; Tatton, WG | 1 |
| Boulton, AA; Davis, BA; Fang, J; Yu, PH | 1 |
| Benmansour, S; Brunswick, DJ | 1 |
| Altagracia, M; Bravo-Velazquez, S; Kravzov, J; Ríos, C | 1 |
| Juorio, AV; Paterson, IA; Zhu, MY | 1 |
| Barber, AJ; Boulton, AA; Yu, PH | 1 |
| Adler, L; Huether, G; Poeggeler, B; Rüther, E | 1 |
| Griffiths, H; Lai, M; Lunec, J; Pall, H; Williams, A | 1 |
| Hattori, T; Sugimoto, T; Takada, M | 1 |
| Lakshmana, MK; Munirathinam, S; Raju, TR | 1 |
| Bernardi, G; Bonci, A; Calabresi, P; Mercuri, NB; Siniscalchi, A; Stefani, A | 1 |
| Hsu, KS; Huang, CC; Su, MT; Tsai, JJ | 1 |
| Leonardi, EK; Mytilineou, C; Olanow, CW; Radcliffe, P; Werner, P | 1 |
| Lai, CT; Yu, PH | 1 |
| Hsu, KS; Huang, CC; Tsai, JJ | 1 |
| Molteni, R; Racagni, G; Riva, MA | 1 |
| Cohen, G; Han, SK; Heinonen, EH; Leonardi, EK; Mytilineou, C; Olanow, CW; Radcliffe, P; Werner, P | 1 |
| Cohen, RM; Karoum, F; Lipper, S; Mellow, AM; Murphy, DL; Pickar, D; Sunderland, T; Tariot, PN | 1 |
| Croll, RP; Pani, AK | 2 |
| Brannan, T; Martínez-Tica, J; Prikhojan, A; Yahr, MD | 1 |
| Carrillo, MC; Kitani, K; Maruyama, W; Naoi, M; Yamamoto, T; Youdim, M | 1 |
| Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Maruyama, W; Minami, C | 1 |
| Awaya, T; Chiba, K; Hayase, N; Kimura, K; Matsubara, K; Ogawa, S; Senda, T; Shimizu, K; Uezono, T | 1 |
| Adachi, YU; Higuchi, H; Satoh, T; Vizi, ES; Watanabe, K | 1 |
| Barbelivien, A; Haapalinna, A; Nyman, L; Sirviö, J | 1 |
| Davis, BA; Dyck, LE | 1 |
| Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Minami, C; Yamamoto, T | 1 |
| Chalmers-Redman, R; Tatton, N; Tatton, W | 1 |
| Haapalinna, A; Niittykoski, M; Sirviö, J | 1 |
| Jenner, P | 1 |
| Inoue, T; Iwamoto, N; Izumi, T; Kato, A; Kitaichi, Y; Koyama, T | 1 |
| Olanow, CW | 1 |
| Kálmán, M; Pálfi, M; Szökó, E | 1 |
| Dell'Antone, P; Drago, D; IbnLkayat, M; Zatta, P | 1 |
| Akao, Y; Maruyama, W; Naoi, M; Shamoto-Nagai, M; Yamaoka, Y; Yi, H | 1 |
| Miklya, I | 1 |
| Bhyrapuneni, G; Manoharan, A; Mohammed, AR; Nirogi, R; Palacharla, RC; Ponnamaneni, RK | 1 |
| Bhatia, M; Kapoor, A; Kumar, A; Kumar, P; Kumar, S | 1 |
9 review(s) available for pargyline and selegiline
| Article | Year |
|---|---|
[Protective therapy in Parkinson's disease].
Topics: Animals; Humans; Levodopa; Pargyline; Parkinson Disease; Selegiline | 1990 |
The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Callithrix; Corpus Striatum; Disease Models, Animal; Dopamine; Ergolines; Humans; Levodopa; Macaca mulatta; Neural Pathways; Pargyline; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Quinpirole; Rats; Saimiri; Selegiline; Species Specificity; Substantia Nigra | 1986 |
The acetylenic monoamine oxidase inhibitors clorgyline, deprenyl, pargyline and J-508: their properties and applications.
Topics: Alkynes; Animals; Binding Sites; Clorgyline; Indans; Indenes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Propylamines; Rats; Selegiline; Substrate Specificity | 1981 |
Amphetamine-metabolites of deprenyl involved in protection against neurotoxicity induced by MPTP and 2'-methyl-MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamines; Animals; Corpus Striatum; Dopamine Antagonists; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotoxins; Pargyline; Rats; Rats, Inbred Strains; Selegiline | 1994 |
Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.
Topics: Aging; Animals; Catalase; Free Radical Scavengers; Humans; Life Expectancy; Neuroprotective Agents; Pargyline; Propylamines; Selegiline; Superoxide Dismutase | 2002 |
Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Glyceraldehyde-3-Phosphate Dehydrogenases; HSP70 Heat-Shock Proteins; Humans; Monoamine Oxidase; Neurons; Neuroprotective Agents; Pargyline; Parkinson Disease; Propylamines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Selegiline; Superoxide Dismutase | 2003 |
Preclinical evidence for neuroprotection with monoamine oxidase-B inhibitors in Parkinson's disease.
Topics: Amphetamines; Animals; Antiparkinson Agents; Apoptosis; Clinical Trials as Topic; Drug Evaluation, Preclinical; Haplorhini; Humans; Inactivation, Metabolic; Indans; Mice; Mice, Transgenic; Models, Neurological; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Oxepins; Oxidative Stress; Pargyline; Parkinson Disease; Propylamines; Selegiline | 2004 |
[Molecular mechanisms of the neuroprotective effect of (-)-deprenyl].
Topics: Animals; Antioxidants; Antiparkinson Agents; Apoptosis; Dopamine; Drug Synergism; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Mitochondria; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Pargyline; Phosphotransferases; Poly(ADP-ribose) Polymerases; Propylamines; Selegiline | 2006 |
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies.
Topics: Aldehydes; Ammonia; Caffeine; Chalcones; Chromones; Clorgyline; Coumarins; Hydrogen Peroxide; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Pyrazoles; Selegiline; Structure-Activity Relationship; Thiazoles; Thiourea | 2022 |
2 trial(s) available for pargyline and selegiline
| Article | Year |
|---|---|
Selectivity of clorgyline and pargyline as inhibitors of monoamine oxidases A and B in vivo in man.
Topics: Blood Platelets; Clorgyline; Hemodynamics; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Selegiline | 1979 |
Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline).
Topics: Biogenic Amines; Chromosome Deletion; Clorgyline; Depressive Disorder; Humans; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Reference Values; Retrospective Studies; Selegiline; Tyramine; X Chromosome | 1998 |
118 other study(ies) available for pargyline and selegiline
| Article | Year |
|---|---|
2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents.
Topics: Animals; Antidepressive Agents; Desipramine; gamma-Aminobutyric Acid; Male; Mice; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triazoles | 1988 |
Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.
Topics: Crystallography, X-Ray; Kinetics; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors | 2005 |
Pyrazoline-based mycobactin analogues as MAO-inhibitors.
Topics: Acetamides; Animals; Binding Sites; Catalytic Domain; Drug Design; Humans; Inhibitory Concentration 50; Linezolid; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Pyrazoles; Rats; Siderophores | 2008 |
New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Topics: Binding Sites; Flavin-Adenine Dinucleotide; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyrazoles; Quinazolinones | 2009 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Inhibition of monoamine oxidase by phthalide analogues.
Topics: Benzofurans; Binding Sites; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Structure-Activity Relationship | 2013 |
The opposite effect of isotype-selective monoamine oxidase inhibitors on adipogenesis in human bone marrow mesenchymal stem cells.
Topics: 3T3-L1 Cells; Adipogenesis; Animals; Antidiuretic Agents; Bone Marrow Cells; Humans; Mesenchymal Stem Cells; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenelzine; Tranylcypromine | 2013 |
α-Tetralone derivatives as inhibitors of monoamine oxidase.
Topics: Enzyme Activation; Humans; Models, Molecular; Monoamine Oxidase Inhibitors; Structure-Activity Relationship; Tetralones | 2014 |
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
Topics: Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Small Molecule Libraries; Thermodynamics | 2015 |
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cations, Divalent; Cell Membrane Permeability; Chelating Agents; Copper; Humans; Iron; Membranes, Artificial; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Reactive Oxygen Species; Selegiline; Solutions; Zinc | 2015 |
Monoamine oxidase inhibitory activities of heterocyclic chalcones.
Topics: Antiparkinson Agents; Chalcones; HeLa Cells; Humans; Hydrocarbons, Fluorinated; Kinetics; Kynuramine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyrroles; Structure-Activity Relationship; Thiophenes | 2015 |
Inhibition of monoamine oxidase by benzoxathiolone analogues.
Topics: Benzoxazoles; Humans; Inhibitory Concentration 50; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Isoforms; Structure-Activity Relationship | 2016 |
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.
Topics: Benzoquinones; Dose-Response Relationship, Drug; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2017 |
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.
Topics: Humans; Indans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Propylamines; Selegiline; Tetrahydronaphthalenes; Tyramine | 2022 |
Cumulative effects of irreversible MAO inhibitors in vivo.
Topics: Animals; Brain; Clorgyline; Female; Liver; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Rats; Selegiline; Serotonin; Time Factors; Tranylcypromine | 1979 |
The effect of monoamine oxidase inhibitors on some arylalkylamines in rate striatum.
Topics: Amines; Animals; Clorgyline; Corpus Striatum; Iproniazid; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Rats; Selegiline; Tranylcypromine; Tryptamines; Tyramine | 1979 |
c-fos mRNA in mouse brain after MPTP treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Blotting, Northern; Brain; Dose-Response Relationship, Drug; Genes, fos; Kinetics; Male; Mazindol; Mice; Neurotoxins; Organ Specificity; Pargyline; Reference Values; RNA; RNA, Messenger; Selegiline; Time Factors | 1992 |
Absence of 2-phenylethylamine binding after monoamine oxidase inhibition in rat brain.
Topics: Animals; Brain; Cell Membrane; Male; Monoamine Oxidase Inhibitors; Neurons; Pargyline; Phenethylamines; Radioligand Assay; Rats; Rats, Inbred Strains; Selegiline | 1992 |
Deprenyl (selegiline), a selective MAO-B inhibitor with active metabolites; effects on locomotor activity, dopaminergic neurotransmission and firing rate of nigral dopamine neurons.
Topics: Animals; Brain; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Male; Methamphetamine; Motor Activity; Neurons; Pargyline; Rats; Rats, Inbred Strains; Selegiline; Synaptic Transmission | 1991 |
The effects of some neuroleptics and d-amphetamine on striatal 2-phenylethylamine in the mouse.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Chlorpromazine; Corpus Striatum; Dextroamphetamine; Dopamine; Fluphenazine; Homovanillic Acid; In Vitro Techniques; Male; Mice; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Selegiline; Spiperone; Synaptic Transmission | 1991 |
Chemically induced Parkinson's disease. III: A study of a possible role of singlet molecular oxygen in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Free Radicals; Lasers; Monoamine Oxidase; Oxygen; Pargyline; Parkinson Disease; Radiation-Sensitizing Agents; Selegiline | 1991 |
Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; MPTP Poisoning; NADPH-Ferrihemoprotein Reductase; Pargyline; Phenobarbital; Piperazines; Piperonyl Butoxide; Proadifen; Selegiline | 1991 |
Isoelectric analysis of 3H-pargyline-labelled monoamine oxidase in rat and carp.
Topics: Animals; Brain; Carps; Clorgyline; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusing; Isoelectric Point; Male; Mitochondria; Mitochondria, Liver; Molecular Weight; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Rats; Rats, Inbred Strains; Selegiline | 1990 |
Effects of selective monoamine oxidase inhibitors on the in vivo release and metabolism of dopamine in the rat striatum.
Topics: Amphetamine; Animals; Catecholamines; Clorgyline; Corpus Striatum; Dopamine; Monoamine Oxidase Inhibitors; Nomifensine; Pargyline; Potassium; Rats; Rats, Inbred Strains; Selegiline; Serotonin; Veratrine | 1990 |
Role of type A and B monoamine oxidase on the formation of 3,4-dihydroxyphenylacetic acid (DOPAC) in tissues from the brain of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cerebral Cortex; Clorgyline; Corpus Striatum; Dopamine; Homovanillic Acid; Isoenzymes; Male; Monoamine Oxidase; Nucleus Accumbens; Pargyline; Rats; Rats, Inbred Strains; Reference Values; Selegiline | 1990 |
Kinetic evaluation of MAO-B-activity following oral administration of selegiline and desmethyl-selegiline in the rat.
Topics: Administration, Oral; Amphetamines; Animals; Clorgyline; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Male; Monoamine Oxidase; Pargyline; Rats; Rats, Inbred Strains; Selegiline | 1990 |
Does FAD-dependent polyamine oxidase contribute to the metabolism of milacemide?
Topics: Acetamides; Animals; Flavin-Adenine Dinucleotide; Glycine; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Pargyline; Polyamine Oxidase; Putrescine; Rats; Rats, Inbred Strains; Selegiline | 1990 |
In vivo studies on the effect of monoamine oxidase inhibitors on dopamine and serotonin metabolism in rat brain areas.
Topics: Animals; Brain; Clorgyline; Corpus Striatum; Dopamine; Electrodes, Implanted; Locus Coeruleus; Monoamine Oxidase Inhibitors; Pargyline; Raphe Nuclei; Rats; Rats, Inbred Strains; Selegiline; Serotonin; Stereotaxic Techniques | 1990 |
In vivo labelling and axonal transport of monoamine oxidase in the rat basal ganglia using radioactive pargyline.
Topics: Animals; Axonal Transport; Basal Ganglia; Clorgyline; Corpus Striatum; Female; Hydroxydopamines; Kainic Acid; Male; Monoamine Oxidase; Oxidopamine; Pargyline; Premedication; Rats; Rats, Inbred Strains; Selegiline; Substantia Nigra | 1986 |
Determination of the absolute concentrations of monoamine oxidase A and B in human tissues.
Topics: Autopsy; Binding Sites; Blood Platelets; Brain; Clorgyline; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Placenta; Selegiline | 1989 |
Steroid regulation of monoamine oxidase activity in the adrenal medulla.
Topics: Adrenal Medulla; Animals; Cattle; Chromaffin System; Clorgyline; Dexamethasone; DNA; Endothelium; Estradiol; Hydrocortisone; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenelzine; Progesterone; Protein Biosynthesis; Selegiline; Steroids; Testosterone | 1989 |
Lesion-induced reductions in trace amine accumulation: dependence on MAO inhibitor pretreatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxydopamines; Male; Monoamine Oxidase Inhibitors; Oxidopamine; Pargyline; Rats; Rats, Inbred Strains; Selegiline; Substantia Nigra; Tryptamines | 1989 |
Potentiation of para-hydroxyamphetamine-induced head-twitch response by inhibition of monoamine oxidase type A in the brain.
Topics: Amphetamines; Animals; Brain; Cerebral Ventricles; Clorgyline; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Monoamine Oxidase; Monoamine Oxidase Inhibitors; p-Hydroxyamphetamine; Pargyline; Selegiline; Stereotyped Behavior | 1989 |
Characterization of monoamine oxidase activity present in human granulocytes and lymphocytes.
Topics: Adult; Binding Sites; Clorgyline; Granulocytes; Humans; Kinetics; Lymphocytes; Male; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Selegiline; Semicarbazides; Substrate Specificity | 1989 |
The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cell Membrane Permeability; Cell Survival; Cytosol; Liver; Male; Mitochondria; Monoamine Oxidase Inhibitors; Pargyline; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Selegiline | 1988 |
Assignment of A and B types of monoamine oxidase in NCB20 hybrid cells to those of the parental cells by peptide mapping.
Topics: Animals; Brain; Cell Line; Chymotrypsin; Clorgyline; Cricetinae; Cricetulus; Electrophoresis, Polyacrylamide Gel; Flavin-Adenine Dinucleotide; Hybrid Cells; Mice; Mice, Inbred A; Mitochondria; Molecular Weight; Monoamine Oxidase; Pargyline; Peptide Fragments; Selegiline | 1986 |
The effect of repeated administration of (-) deprenyl on the phenylethylamine-induced stereotypy in rats.
Topics: Alkynes; Animals; Clorgyline; Female; Indans; Male; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Rats; Rats, Inbred Strains; Selegiline; Stereotyped Behavior | 1986 |
The effects of monoamine oxidase inhibitors on the ejaculatory response induced by 5-methoxy-N,N-dimethyltryptamine in the rat.
Topics: Animals; Benzamides; Clorgyline; Dose-Response Relationship, Drug; Ejaculation; Male; Methoxydimethyltryptamines; Moclobemide; Monoamine Oxidase Inhibitors; Nialamide; p-Chloroamphetamine; Pargyline; Rats; Receptors, Serotonin; Selegiline; Serotonin; Time Factors | 1986 |
Investigation of dopamine content, synthesis, and release in the rabbit retina in vitro: I. Effects of dopamine precursors, reserpine, amphetamine, and L-DOPA decarboxylase and monoamine oxidase inhibitors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Dopamine; Female; Levodopa; Male; Monoamine Oxidase Inhibitors; Pargyline; Rabbits; Reserpine; Retina; Selegiline; Tyrosine | 1986 |
Possible melatonin involvement in the hypotensive effect of MAO inhibitors.
Topics: Animals; Blood Pressure; Clorgyline; Isoenzymes; Male; Melatonin; Monoamine Oxidase Inhibitors; Pargyline; Pineal Gland; Rats; Rats, Inbred Strains; Selegiline | 1986 |
SR 95191, a selective inhibitor of type A monoamine oxidase with dopaminergic properties. I. Psychopharmacological profile in rodents.
Topics: 5-Hydroxytryptophan; Amphetamines; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Body Temperature; Catalepsy; Clorgyline; Drug Interactions; Female; Haloperidol; Imipramine; Levodopa; Male; Mice; Moclobemide; Monoamine Oxidase Inhibitors; Motor Activity; Nomifensine; Oxotremorine; Pargyline; Piperidines; Pyridazines; Rats; Rats, Inbred Strains; Reserpine; Selegiline; Stereotyped Behavior | 1987 |
MAO type B inhibitors as adjunct to L-dopa therapy.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkynes; Animals; Brain; Drug Therapy, Combination; Humans; Indans; Isoenzymes; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Receptors, Dopamine; Selegiline; Structure-Activity Relationship; Tyramine | 1987 |
N-propargylbenzylamine, a major metabolite of pargyline, is a potent inhibitor of monoamine oxidase type B in rats in vivo: a comparison with deprenyl.
Topics: Animals; Benzylamines; Biogenic Amines; Brain Chemistry; Male; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Rats; Rats, Inbred Strains; Selegiline | 1987 |
Conditioned taste aversion induced in rats by intracerebral or systemic administration of monoamine oxidase inhibitors.
Topics: Animals; Avoidance Learning; Brain; Clorgyline; Injections; Injections, Intraperitoneal; Male; Monoamine Oxidase Inhibitors; Pargyline; Rats; Selegiline; Taste | 1987 |
Effects of different monoamine oxidase inhibitors on the metabolism of L-dopa in the rat brain.
Topics: Animals; Brain; Catecholamines; Clorgyline; Corpus Striatum; Dopamine; Hypothalamus; Levodopa; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Pargyline; Rats; Rats, Inbred Strains; Selegiline | 1987 |
Inhibition of MAO B, but not MAO A, blocks DSP-4 toxicity on central NE neurons.
Topics: Animals; Benzylamines; Brain Chemistry; Hypothalamus; Male; Methoxyhydroxyphenylglycol; Mice; Monoamine Oxidase Inhibitors; Neurotoxins; Norepinephrine; Pargyline; Selegiline | 1987 |
Differential postnatal development of monoamine oxidases A and B in the blood-brain barrier of the rat.
Topics: Aging; Animals; Benzylamines; Blood-Brain Barrier; Brain; Cerebral Cortex; Clorgyline; Microcirculation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Rats; Rats, Inbred Strains; Selegiline; Substrate Specificity; Tryptamines | 1987 |
Different effects of monoamine oxidase inhibition on MPTP depletion of heart and brain catecholamines in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cyclopropanes; Dopamine; Liver; Male; Mice; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Oxidation-Reduction; Pargyline; Pyridines; Selegiline | 1988 |
[3H]Ro 16-6491, a selective probe for affinity labelling of monoamine oxidase type B in human brain and platelet membranes.
Topics: Affinity Labels; Benzamides; Binding Sites; Blood Platelets; Borohydrides; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Molecular Weight; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Selegiline; Tritium | 1988 |
[3H]tryptamine binding sites are not identical to monoamine oxidase in rat brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding, Competitive; Brain; Clorgyline; Male; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline; Synaptosomes; Tissue Distribution; Tryptamines | 1988 |
Disposition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice before and after monoamine oxidase and catecholamine reuptake inhibition.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Glands; Animals; Autoradiography; Brain; Catecholamines; Clorgyline; Female; Image Processing, Computer-Assisted; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Nomifensine; Pargyline; Pyridines; Scintillation Counting; Selegiline; Tissue Distribution | 1988 |
Selective inhibition of MAO-A, not MAO-B, results in antidepressant-like effects on DRL 72-s behavior.
Topics: Animals; Antidepressive Agents; Clorgyline; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Monoamine Oxidase Inhibitors; Pargyline; Piperidines; Rats; Rats, Inbred Strains; Reinforcement Schedule; Selegiline | 1988 |
Reciprocal changes in striatal dopamine and beta-phenylethylamine induced by reserpine in the presence of monoamine oxidase inhibitors.
Topics: Animals; Biogenic Amines; Clorgyline; Corpus Striatum; Dopamine; Male; Mice; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Reserpine; Selegiline | 1988 |
Studies on the mechanism of action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Culture Techniques; Female; Kinetics; Monoamine Oxidase; Pargyline; Pregnancy; Pyridines; Rats; Selegiline; Substantia Nigra | 1985 |
Pharmacological treatment of attention deficit disorder, residual type (ADD,RT, "minimal brain dysfunction," "hyperactivity") in adults.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Humans; Methylphenidate; Pargyline; Pemoline; Phenethylamines; Selegiline | 1985 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: correspondence of its binding sites to monoamine oxidase in rat brain, and inhibition of dopamine oxidative deamination in vivo and in vitro.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Binding Sites; Clorgyline; Corpus Striatum; Deamination; Dopamine; In Vitro Techniques; Male; Monoamine Oxidase; Oxidation-Reduction; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline; Subcellular Fractions | 1985 |
Down-regulation of [3H]5-hydroxytryptamine binding sites in chick embryo brain by monoamine oxidase inhibitors or fenfluramine and potentiation by d,l-5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Animals; Binding Sites; Brain; Chick Embryo; Clorgyline; Fenfluramine; Mice; Monoamine Oxidase Inhibitors; Pargyline; Rats; Selegiline; Serotonin | 1985 |
Prevention of MPTP-induced neurotoxicity by AGN-1133 and AGN-1135, selective inhibitors of monoamine oxidase-B.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzylamines; Brain; Dopamine; Indans; Indenes; Male; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Pargyline; Pyridines; Selegiline; Tryptamines | 1985 |
Histochemical localization of monoamine oxidase types A and B in the adrenal gland.
Topics: Adrenal Cortex; Adrenal Glands; Adrenal Medulla; Animals; Cats; Cattle; Clorgyline; Dogs; Histocytochemistry; Monoamine Oxidase; Pargyline; Phenethylamines; Rats; Selegiline; Serotonin; Species Specificity; Substrate Specificity | 1985 |
Evidence that a preferred substrate for type B monoamine oxidase mediates stimulus properties of MAO inhibitors: a possible role for beta-phenylethylamine in the cocaine cue.
Topics: Animals; Cocaine; Cues; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Stimulus; Hydrazines; Male; Monoamine Oxidase Inhibitors; Nialamide; Pargyline; Rats; Selegiline; Tranylcypromine; Tryptamines | 1980 |
Effects of inhibitors of monoamine oxidase activity in goldfish (Carassius auratus) brain in vitro.
Topics: Animals; Brain; Clorgyline; Cyprinidae; Goldfish; Harmaline; In Vitro Techniques; Kinetics; Monoamine Oxidase Inhibitors; Pargyline; Selegiline; Time Factors | 1981 |
The kinetics of inhibition of type-B monoamine oxidase by clorgyline, pargyline and (-)-deprenyl.
Topics: Animals; Clorgyline; In Vitro Techniques; Kinetics; Monoamine Oxidase Inhibitors; Pargyline; Rats; Selegiline | 1981 |
Mechanism of serotonin effects on prolactin and growth hormone secretion in domestic fowl.
Topics: alpha-Methyltyrosine; Animals; Brain; Chickens; Clorgyline; Fenclonine; Growth Hormone; Imipramine; Male; Methyltyrosines; Pargyline; Prolactin; Receptors, Serotonin; Selegiline; Serotonin; Tryptophan | 1983 |
(-)-Deprenyl a selective MAO "B' inhibitor, increases [3H]imipramine binding and decreases beta-adrenergic receptor function.
Topics: Animals; Dextroamphetamine; Hippocampus; Imipramine; Kinetics; Male; Norepinephrine; Pargyline; Phenethylamines; Protein Binding; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Selegiline; Synaptic Membranes | 1983 |
Cardiovascular effects of (+)- and (-)-tranylcypromine compared to other monoamine oxidase inhibitors.
Topics: Anesthesia; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Hemodynamics; Humans; Monoamine Oxidase Inhibitors; Myocardial Contraction; Pargyline; Reserpine; Selegiline; Stereoisomerism; Tranylcypromine | 1983 |
Clinical and laboratory studies with selective monoamine-oxidase-inhibiting drugs. Implications for hypothesized neurotransmitter changes associated with depression and antidepressant drug effects.
Topics: Behavior; Biogenic Amines; Clorgyline; Depressive Disorder; Dopamine; Histamine; Humans; Monoamine Oxidase Inhibitors; Norepinephrine; Pargyline; Phenethylamines; Selegiline; Serotonin; Tyramine | 1983 |
Monoamine oxidase in pancreatic islets, exocrine pancreas, and liver from rats. Characterization with clorgyline, deprenyl, pargyline, tranylcypromine, and amezinium.
Topics: Animals; Clorgyline; Female; Insulin; Insulin Secretion; Islets of Langerhans; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pancreas; Pargyline; Pyridazines; Rats; Rats, Inbred Strains; Selegiline; Tranylcypromine | 1983 |
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Brain; Kinetics; Male; Mitochondria; Monoamine Oxidase; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline | 1984 |
Localization and identification of covalently bound flavoproteins in rat liver mitochondria by prelabeling of their flavin moiety.
Topics: Animals; Benzylamines; Carbon Radioisotopes; Clorgyline; Flavoproteins; Male; Mitochondria, Liver; Molecular Weight; Monoamine Oxidase; Oxidoreductases, N-Demethylating; Pargyline; Protein Binding; Rats; Rats, Inbred Strains; Riboflavin; Sarcosine Dehydrogenase; Selegiline; Serotonin; Tritium; Tyramine | 1984 |
Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Caudate Nucleus; Dopamine; Female; Homovanillic Acid; Macaca fascicularis; Pargyline; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline | 1984 |
Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) on audiogenic seizures in DBA/2J mice.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Benzofurans; Carbolines; Citalopram; Clomipramine; Clorgyline; Fluoxetine; Harmine; Indoles; Methoxydimethyltryptamines; Mice; Mice, Inbred DBA; N,N-Dimethyltryptamine; Pargyline; Propylamines; Quipazine; Seizures; Selegiline | 1980 |
Monoacylcadaverines as substrates for both monoamine oxidase and diamine oxidase; low rates of activity.
Topics: Amine Oxidase (Copper-Containing); Animals; Cadaverine; Clorgyline; Diamines; Kidney; Kinetics; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Rats; Selegiline; Substrate Specificity; Swine | 1980 |
Species differences in the deamination of dopamine and other substrates for monoamine oxidase in brain.
Topics: Animals; Brain; Caudate Nucleus; Cerebral Cortex; Chlorocebus aethiops; Clorgyline; Deamination; Dopamine; Female; Humans; Macaca mulatta; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Rats; Selegiline; Serotonin; Species Specificity; Substrate Specificity; Tyramine | 1980 |
Studies on the pargyline-binding site of different types of monoamine oxidase.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Clorgyline; Female; Humans; In Vitro Techniques; Liver; Male; Monoamine Oxidase; Pargyline; Peptide Hydrolases; Pregnancy; Rats; Selegiline; Tissue Distribution | 1981 |
Fungal metabolism of (-)-deprenyl and pargyline.
Topics: Amphetamine; Benzylamines; Biotransformation; Mucorales; Pargyline; Phenethylamines; Selegiline | 1981 |
[Cardiovascular effects of (+)- and (-)-tranylcypromine compared to other monoamine oxidase inhibitors in animal studies (author's transl)].
Topics: Animals; Blood Pressure; Cats; Coronary Circulation; Drug Interactions; Female; Guinea Pigs; Male; Monoamine Oxidase Inhibitors; Myocardial Contraction; Norepinephrine; Pargyline; Selegiline; Stereoisomerism; Tranylcypromine; Tyramine | 1982 |
Preferential inhibition of the B-form of monoamine oxidase in the liver of rats given 3'-methyl-4-dimethylaminoazobenzene in the diet.
Topics: Animals; Clorgyline; Diet; Kinetics; Male; Methyldimethylaminoazobenzene; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; p-Dimethylaminoazobenzene; Pargyline; Rats; Selegiline | 1982 |
The nature of the inhibition of rat liver monoamine oxidase types A and B by the acetylenic inhibitors clorgyline, l-deprenyl and pargyline.
Topics: Animals; Clorgyline; Kinetics; Liver; Male; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Propylamines; Proteins; Rats; Rats, Inbred Strains; Selegiline; Serotonin | 1982 |
Irreversible inhibition of rat liver mitochondrial MAO A and MAO B by enantiomers of deprenyl and alpha-methylpargyline.
Topics: Animals; Male; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Pargyline; Rats; Rats, Sprague-Dawley; Selegiline; Stereoisomerism | 1995 |
Inhibition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolic activity of porcine FAD-containing monooxygenase by selective monoamine oxidase-B inhibitors.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Female; Microsomes, Liver; Monoamine Oxidase Inhibitors; Oxygenases; Pargyline; Selegiline; Substrate Specificity; Swine | 1995 |
Thyroid iodide transport is reduced by administration of monoamine oxidase A inhibitors to rats.
Topics: Animals; Biological Transport; Clorgyline; Iodides; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organ Culture Techniques; Pargyline; Rats; Rats, Wistar; Selegiline; Thyroid Gland; Tranylcypromine | 1994 |
Inhibition by (-)-deprenyl of agonist-evoked contractions in rabbit aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clorgyline; Cocaine; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Histamine H1 Antagonists; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pargyline; Phenylephrine; Potassium; Rabbits; Selegiline; Serotonin Antagonists | 1994 |
Repeated administrations of (-)-deprenyl increase [3H]MK801 binding in rat brain and antagonize the impairment of passive avoidance conditioning induced by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Brain; Cell Membrane; Dextroamphetamine; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Ketamine; Male; Pargyline; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Selegiline; Synaptic Membranes | 1994 |
Suppression of hydroxyl radical formation by MAO inhibitors: a novel possible neuroprotective mechanism in dopaminergic neurotoxicity.
Topics: Ascorbic Acid; Clorgyline; Dopamine; Dopamine Agents; Dopamine Antagonists; Hydroxyl Radical; Melanins; Monoamine Oxidase Inhibitors; Nervous System; Oxidation-Reduction; Pargyline; Selegiline | 1994 |
Is brain superoxide dismutase activity increased following chronic treatment with 1-deprenyl?
Topics: Animals; Brain; Enzyme-Linked Immunosorbent Assay; Male; Monoamine Oxidase Inhibitors; Pargyline; Rats; Rats, Wistar; Selegiline; Superoxide Dismutase; Time Factors | 1994 |
(-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis.
Topics: Animals; Apoptosis; Cell Nucleus; Cell Survival; Culture Media, Serum-Free; DNA, Neoplasm; Kinetics; Neoplasm Proteins; Nerve Growth Factors; Pargyline; PC12 Cells; Rats; Selegiline; Time Factors | 1994 |
Neuroprotective effects of some monoamine oxidase-B inhibitors against DSP-4-induced noradrenaline depletion in the mouse hippocampus.
Topics: Animals; Benzylamines; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Male; Mice; Monoamine Oxidase Inhibitors; Neurons; Neurotransmitter Uptake Inhibitors; Norepinephrine; Pargyline; Phenelzine; Propylamines; Selegiline; Time Factors | 1994 |
The MAO-B inhibitor deprenyl, but not the MAO-A inhibitor clorgyline, potentiates the neurotoxicity of p-chloroamphetamine.
Topics: Animals; Autoradiography; Body Temperature; Brain; Clorgyline; Drug Synergism; Iodocyanopindolol; Male; Nerve Endings; Nervous System Diseases; Neurons; p-Chloroamphetamine; Pargyline; Pindolol; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selegiline; Serotonin | 1994 |
Enhancement of striatal lipid peroxidation induced by 1-methyl-4-phenylpyridinium in mouse brain is blocked by MAO-B inhibitors.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Clorgyline; Lipid Peroxidation; Male; Mice; Monoamine Oxidase Inhibitors; Neostriatum; Pargyline; Selegiline | 1994 |
Dopamine metabolism in the guinea pig striatum: role of monoamine oxidase A and B.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Guinea Pigs; Homovanillic Acid; Male; Monoamine Oxidase; Pargyline; Selegiline | 1994 |
Chronic effects of monoamine oxidase-B inhibitors on the behaviour of aged mice.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Brain; Drinking; Isoenzymes; Locomotion; Male; Memory; Mice; Monoamine Oxidase Inhibitors; Pargyline; Selegiline; Time Factors | 1993 |
Effects of indirectly acting 5-HT receptor agonists on circulating melatonin levels in rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Fenfluramine; Fluoxetine; Injections, Intraperitoneal; Male; Melatonin; Pargyline; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin Receptor Agonists; Tryptophan | 1993 |
An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Catalase; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lipid Peroxides; MPTP Poisoning; Neurons; Pargyline; Rats; Reactive Oxygen Species; Selegiline; Superoxide Dismutase; Tumor Cells, Cultured | 1993 |
MPTP neurotoxicity to cerebellar Purkinje cells in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benztropine; Dose-Response Relationship, Drug; Male; Mazindol; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; MPTP Poisoning; Neurotoxins; Pargyline; Purkinje Cells; Selegiline | 1993 |
(-) deprenyl attenuates aluminium induced neurotoxicity in primary cortical cultures.
Topics: Aluminum Chloride; Aluminum Compounds; Amphetamine; Animals; Animals, Newborn; Biomarkers; Cell Survival; Cells, Cultured; Cerebral Cortex; Chlorides; L-Lactate Dehydrogenase; Neurons; Neurotoxins; Pargyline; Rats; Rats, Wistar; Selegiline | 1996 |
Electrophysiological effects of monoamine oxidase inhibition on rat midbrain dopaminergic neurones: an in vitro study.
Topics: Animals; Clorgyline; Dopamine; Dopamine Antagonists; Electrophysiology; Evoked Potentials; In Vitro Techniques; Mesencephalon; Monoamine Oxidase Inhibitors; Neurons; Pargyline; Patch-Clamp Techniques; Rats; Rats, Wistar; Selegiline; Substantia Nigra; Ventral Tegmental Area | 1996 |
L-deprenyl (selegiline) decreases excitatory synaptic transmission in the rat hippocampus via a dopaminergic mechanism.
Topics: Animals; Anticonvulsants; Dopamine; Dose-Response Relationship, Drug; Glutamine; Hippocampus; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; N-Methylaspartate; Pargyline; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Selegiline; Synaptic Transmission | 1996 |
L-deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Death; Culture Media; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Mesencephalon; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Neuroprotective Agents; Pargyline; Rats; Receptors, Glutamate; Selegiline | 1997 |
R(-)-deprenyl potentiates dopamine-induced cytotoxicity toward catecholaminergic neuroblastoma SH-SY5Y cells.
Topics: Antioxidants; Dopamine; Drug Synergism; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neuroblastoma; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Pargyline; Propylamines; Reactive Oxygen Species; Selegiline; Tumor Cells, Cultured | 1997 |
L-deprenyl (selegiline) limits the repetitive firing of action potentials in rat hippocampal CA1 neurons via a dopaminergic mechanism.
Topics: Action Potentials; Analysis of Variance; Animals; Antiparkinson Agents; Dopamine; In Vitro Techniques; Male; Membrane Potentials; Monoamine Oxidase Inhibitors; Pargyline; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Selegiline | 1997 |
L-deprenyl potentiates cAMP-induced elevation of FGF-2 mRNA levels in rat cortical astrocytes.
Topics: Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Fibroblast Growth Factor 2; Gene Expression; Nerve Growth Factors; Pargyline; Rats; RNA, Messenger; Selegiline | 1997 |
Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion.
Topics: Amphetamines; Animals; Ascorbic Acid; Buthionine Sulfoximine; Cells, Cultured; Dose-Response Relationship, Drug; Glutathione; Mazindol; Mesencephalon; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Pargyline; Rats; Selegiline; Tyrosine 3-Monooxygenase | 1998 |
Pharmacological analysis of monoamine synthesis and catabolism in the scallop, Placopecten magellanicus.
Topics: alpha-Methyltyrosine; Animals; Biogenic Monoamines; Catecholamines; Catechols; Clorgyline; Fenclonine; Indoles; Methylation; Mollusca; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Pargyline; Selegiline; Serotonin Agents | 1998 |
In vivo comparison of the effects of inhibition of MAO-A versus MAO-B on striatal L-DOPA and dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline | 1995 |
Catechol concentrations in the hemolymph of the scallop, Placopecten magellanicus.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catechol O-Methyltransferase Inhibitors; Catecholamines; Chromatography, High Pressure Liquid; Clorgyline; Dihydroxyphenylalanine; Dopamine; Female; Hemolymph; Male; Mollusca; Monoamine Oxidase Inhibitors; Pargyline; Selegiline; Sexual Behavior, Animal | 2000 |
Mechanism underlying anti-apoptotic activity of a (-)deprenyl-related propargylamine, rasagiline.
Topics: Animals; Apoptosis; Humans; Indans; Molecular Structure; Molsidomine; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Pargyline; Propylamines; Rats; Rats, Inbred F344; Selegiline; Tumor Cells, Cultured | 2000 |
Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl.
Topics: Age Factors; Animals; Brain; Catalase; Dogs; Dopamine; Dose-Response Relationship, Drug; Longevity; Mice; Mice, Inbred Strains; Pargyline; Propylamines; Rats; Rats, Inbred Strains; Selegiline; Sex Factors; Superoxide Dismutase | 2000 |
L-Deprenyl prevents the cell hypoxia induced by dopaminergic neurotoxins, MPP(+) and beta-carbolinium: a microdialysis study in rats.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Carbolines; Cell Hypoxia; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Herbicides; Lactic Acid; Male; Microdialysis; Mitochondria; Monoamine Oxidase Inhibitors; Neostriatum; Neurons; Neuroprotective Agents; Neurotoxins; Pargyline; Parkinson Disease; Rats; Rats, Wistar; Selegiline | 2001 |
Oxygen inhalation enhances striatal dopamine metabolism and monoamineoxidase enzyme inhibition prevents it: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Inhalation; Animals; Clorgyline; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Hyperoxia; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxygen; Pargyline; Rats; Rats, Sprague-Dawley; Selegiline | 2001 |
Inhibition of MAO-A activity enhances behavioural activity of rats assessed using water maze and open arena tasks.
Topics: Animals; Behavior, Animal; Clorgyline; Male; Maze Learning; Memory; Monoamine Oxidase Inhibitors; Motor Activity; Pargyline; Rats; Rats, Wistar; Selegiline; Swimming; Weight Gain | 2001 |
Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B1; Enzyme Inhibitors; Female; Kinetics; Microsomes, Liver; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Rats; Rats, Wistar; Selegiline; Ultrafiltration | 2001 |
Selegiline reduces N-methyl-D-aspartic acid induced perturbation of neurotransmission but it leaves NMDA receptor dependent long-term potentiation intact in the hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Pargyline; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Selegiline; Synaptic Transmission | 2003 |
Effects of co-administration of a selective serotonin reuptake inhibitor and monoamine oxidase inhibitors on 5-HT-related behavior in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Clorgyline; Dose-Response Relationship, Drug; Drug Synergism; Fluvoxamine; Male; Monoamine Oxidase Inhibitors; Motor Activity; Pargyline; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin; Serotonin Syndrome | 2006 |
Rationale for considering that propargylamines might be neuroprotective in Parkinson's disease.
Topics: Clinical Trials as Topic; Evidence-Based Medicine; Humans; Indans; Neuroprotective Agents; Pargyline; Parkinson Disease; Practice Guidelines as Topic; Practice Patterns, Physicians'; Propylamines; Selegiline; Treatment Outcome | 2006 |
Acidic vesicles of the endo-exocytic pathways as targets for some anti-monoamine oxidase drugs.
Topics: Acid-Base Equilibrium; Acids; Alzheimer Disease; Amantadine; Animals; Brain; Brain Chemistry; Brain Diseases; Cell Line, Tumor; Clorgyline; Endocytosis; Exocytosis; Hydrogen-Ion Concentration; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organelles; Pargyline; Parkinson Disease; Protons; Selegiline; Signal Transduction; Transport Vesicles | 2009 |
Neuroprotection by propargylamines in Parkinson's disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers.
Topics: Alkynes; Cell Death; Cell Line, Tumor; Energy Metabolism; Genetic Markers; Glial Cell Line-Derived Neurotrophic Factor; Humans; Indans; Membrane Potentials; Mitochondria; Neuroblastoma; Neuroprotective Agents; NF-kappa B; Oligonucleotide Array Sequence Analysis; Pargyline; Parkinson Disease; Propylamines; Proto-Oncogene Proteins c-bcl-2; Selegiline | 2007 |
[A comparison of the pharmacology of (-)-deprenyl to N-methylpropargylamine-1-aminoindane (J-508) and rasagiline, the desmethyl-analogue of J-508].
Topics: Adrenergic Uptake Inhibitors; Animals; Brain Stem; Catecholamines; Clorgyline; Indans; Learning; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Pargyline; Rats; Selegiline; Tetrabenazine | 2008 |
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.
Topics: Bupropion; Clorgyline; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2B6 Inhibitors; Drug Interactions; Glutathione; Humans; Hydroxylation; Inhibitory Concentration 50; Kinesics; Microsomes, Liver; Monoamine Oxidase Inhibitors; Pargyline; Phenelzine; Selegiline | 2015 |