pargyline has been researched along with propargylamine in 195 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (1.54) | 18.7374 |
| 1990's | 9 (4.62) | 18.2507 |
| 2000's | 67 (34.36) | 29.6817 |
| 2010's | 91 (46.67) | 24.3611 |
| 2020's | 25 (12.82) | 2.80 |
| Authors | Studies |
|---|---|
| Erikson, JM; Prough, RA | 1 |
| Gunn, CE; Lyles, GA; Precious, E | 1 |
| Benavides, J; Croci, N; Strolin Benedetti, M | 1 |
| Greenaway, FT; He, Z; Nadkarni, DV; Sayre, LM | 1 |
| Chalmers, J; Lyles, GA | 1 |
| Boulton, AA; Davis, BA; Fang, J; Yu, PH | 1 |
| Leitner, I; Nussbaumer, P; Stütz, A | 1 |
| Boulton, AA; Davis, BA; Yu, PH | 1 |
| Cserháti, T; Szögyi, M | 1 |
| Cserháti, T | 1 |
| Forgács, E | 1 |
| Davis, BA; Yu, PH | 1 |
| Andringa, G; Cools, AR; Hafmans, TG; Stoof, JC; Unger, W; van Oosten, RV; Veening, J | 1 |
| Carrillo, MC; Kitani, K; Maruyama, W; Naoi, M; Yamamoto, T; Youdim, M | 1 |
| Maruyama, W; Naoi, M | 2 |
| Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Maruyama, W; Minami, C | 1 |
| Andringa, G; Cools, AR | 1 |
| Chalmers-Redman, RM; Mittag, TW; Podos, SM; Sud, A; Tatton, WG | 1 |
| Maruyama, W; Naoi, M; Youdim, MB | 1 |
| Hermecz, I; Szabó, A | 1 |
| Carlile, GW; Chalmers-Redman, RM; Ju, WJ; Mammen, M; Pong, AW; Tatton, NA; Tatton, WG | 1 |
| Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Minami, C; Yamamoto, T | 1 |
| Li, CJ; Wei, C | 1 |
| Brown, T; Cuenoud, B; Darby, RA; Fox, KR; Sollogoub, M | 1 |
| Chorev, M; Finberg, J; Finkelstein, N; Friedman, R; Goldenberg, W; Goren, T; Gross, A; Herzig, Y; Huang, W; Krais, B; Lavian, G; Lerner, D; Miskolczi, I; Molnar, S; Rantal, F; Razin, M; Sterling, J; Tamas, T; Toth, G; Weinstock, M; Youdim, MB; Zagyva, A; Zekany, A | 1 |
| Du Bois, J; Fiori, KW; Fleming, JJ | 1 |
| Ciufolini, MA; Coqueron, PY; Didier, C | 1 |
| Chalmers-Redman, R; Tatton, N; Tatton, W | 1 |
| Jeon, HB; Sayre, LM | 1 |
| Gommermann, N; Knochel, P; Koradin, C; Polborn, K | 1 |
| Hoveyda, AH; Snapper, ML; Traverse, JF | 1 |
| Akullian, LC; Hoveyda, AH; Snapper, ML | 1 |
| Amit, T; Bar-Am, O; Yogev-Falach, M; Youdim, MB | 1 |
| Andringa, G; Cools, AR; Eshuis, S; Ibrahim, M; Leenders, KL; Maguire, RP; Perentes, E; Roth, D | 1 |
| Lazarovici, P; Lecht, S; Tabakman, R | 1 |
| Götz, ME; Riederer, P | 1 |
| Jeon, HB; Qiao, C; Sayre, LM | 1 |
| Dooley, DM; Duff, AP; Freeman, HC; Guss, JM; Jeon, HB; Langley, DB; O'Connell, KM; Sayre, LM; Shepard, EM; Sun, G | 1 |
| Dance, I | 1 |
| Gao, G; Masuda, T; Sanda, F | 1 |
| Jenner, P | 1 |
| Fridkin, M; Youdim, MB; Zheng, H | 1 |
| Alper, H; Park, SB | 1 |
| Kamakura, T; Nakamura, H; Onagi, S | 1 |
| Kratzer, R; Nidetzky, B | 1 |
| Akao, Y; Iwasa, K; Maruyama, W; Naoi, M; Takahashi, T; Yi, H; Youdim, MB | 1 |
| Holman, TR; Hrovat, KJ; Huang, D; Musich, C; Ohri, RV; Radosevich, AT; Toste, FD | 1 |
| Amit, T; Bar-Am, O; Weinreb, O; Youdim, MB | 2 |
| Amit, T; Bar-Am, O; Chillag-Talmor, O; Weinreb, O; Youdim, MB | 1 |
| Gommermann, N; Knochel, P | 1 |
| Che, CM; Liu, Y; Lo, VK; Wong, MK | 1 |
| Castagnolo, D; Dragoni, S; Porcari, V; Travagli, M; Valoti, M | 1 |
| Amano, N; Furusaki, Y; Kakiuchi, K; Morikawa, S; Yamazaki, S; Zenke, K | 1 |
| Aschwanden, P; Carreira, EM; Stephenson, CR | 1 |
| Olanow, CW | 1 |
| Kálmán, M; Pálfi, M; Szökó, E | 1 |
| Ellman, JA; Patterson, AW | 1 |
| Monteiro, MJ; Urbani, CN; Whittaker, MR | 1 |
| Amit, T; Bar-Am, O; Mandel, S; Sagi, Y; Weinreb, O; Youdim, MB | 1 |
| Bolm, C; Zani, L | 1 |
| Janovský, I; Knolle, W; Naumov, S; Williams, F | 1 |
| Bonfield, ER; Li, CJ | 1 |
| Frödin, M | 1 |
| Fréchet, JM; Goodwin, AP; Lam, SS | 1 |
| Berhal, F; Royer, J; Turcaud, S | 1 |
| Akao, Y; Maruyama, W; Naoi, M; Shamoto-Nagai, M; Yamaoka, Y; Yi, H | 1 |
| Che, CM; Lo, VK; Wong, MK | 1 |
| Delville, MM; Detz, RJ; Hiemstra, H; van Maarseveen, JH | 1 |
| Che, CM; Liu, XY | 1 |
| Alexandre, A; Cappellotto, M; Zoccarato, F | 1 |
| Amit, T; Bar-Am, O; Berdichevski, A; Binah, O; Kleiner, Y; Liani, E; Maor, G; Reiter, I; Youdim, MB | 1 |
| Frauenrath, H; Hoheisel, TN; Jahnke, E; Neuhaus, S; Weiss, J | 1 |
| Vogel, P; Volla, CM | 1 |
| Boersch, C; Frank, W; Merkul, E; Müller, TJ | 1 |
| Cao, K; Fan, CA; Tu, YQ; Zhang, FM; Zhuo, XT | 1 |
| Kerr, MA; Lebold, TP; Leduc, AB | 1 |
| Böhl, M; Fedorov, R; Gutzeit, HO; Jäger, A; Knölker, HJ; Manstein, DJ; Martin, R; Richter, S | 1 |
| Chen, X; Jou, MJ; Kim, HJ; Kim, HN; Lee, SG; Swamy, KM; Yoon, J | 1 |
| Che, CM; Lo, VK; Wong, MK; Zhou, CY | 1 |
| Nakamura, S; Nakamura, Y; Ohara, M; Shibata, N; Toru, T | 1 |
| He, Z; Yudin, AK | 1 |
| Cole, PA; Culhane, JC; Wang, D; Yen, PM | 1 |
| Kaur, P; Li, G; Pan, Y; Shakya, G; Sun, H | 1 |
| Pereshivko, OP; Peshkov, VA; Van der Eycken, EV | 1 |
| Amit, T; Bar-Am, O; Mandel, S; Weinreb, O; Youdim, MB | 1 |
| Aguilar, D; Contel, M; Urriolabeitia, EP | 1 |
| Hu, J; Liu, J | 1 |
| Debreczeni, N; Fodor, A; Gresits, I; Hell, Z; Kiss, A | 1 |
| Díaz, DD; Guenet, JM; Morin, E; Remy, JS; Wagner, A | 1 |
| De, CK; Klauber, EG; Seidel, D; Shah, TK | 1 |
| Blencowe, A; Qiao, G; Sulistio, A; Widjaya, A; Zhang, X | 1 |
| Chen, G; Gao, S; Lin, Z; Liu, Q; Qiu, B; Qiu, S | 1 |
| Hong, L; Sun, W; Wang, R; Zhu, G | 1 |
| Cheng, D; Du, P; Li, X; Wang, H; Xu, X | 1 |
| Dou, XY; Gao, J; He, LN; Song, QW; Yang, ZZ | 1 |
| Andrisano, V; Bartolini, M; Bolea, I; Chioua, M; de los Ríos, C; Gálvez, E; Iriepa, I; Marco-Contelles, J; Moraleda, I; Samadi, A; Unzeta, M; Valderas, C | 1 |
| Haeffner, F; Hoveyda, AH; Snapper, ML; Vieira, EM | 1 |
| Ben-Tahar, W; Gnaccarini, C; Keillor, JW; Lubell, WD; Mulani, A; Pelletier, JN; Roy, I | 1 |
| Lebel, H; Spitz, C; Trudel, C | 1 |
| Arseniyadis, S; Christoph, S; Cossy, J; Kolleth, A | 1 |
| Larsen, CH; Nguyen, M; Pierce, CJ | 1 |
| Jiang, Z; Lu, P; Wang, Y | 1 |
| Gulyas, B; Halldin, C; Heinrich, T; Keller, É; Kettschau, G; Lehmann, L; Nag, S; Thiele, A; Varrone, A | 1 |
| Bolea, I; Gella, A; Unzeta, M | 1 |
| Csuk, R; Nitsche, C; Sczepek, R; Siewert, B | 1 |
| Nandakumar, A; Perumal, PT | 1 |
| Gurubrahamam, R; Periasamy, M | 1 |
| González-Béjar, M; Grenier, M; Hallett-Tapley, GL; Peters, K; Scaiano, JC | 1 |
| Balamurugan, R; Chien, CC; Chiu, YH; Liu, JH; Wu, KM | 1 |
| Csuk, R; Nitsche, C; Schwarz, S; Sczepek, R; Siewert, B | 1 |
| Li, L; Liu, MQ; Shu, C; Wang, SS; Ye, LW | 1 |
| Li, X; Wan, B; Xin, X; Yu, X | 1 |
| Mashima, K; Morimoto, H; Morisaki, K; Nomaguchi, JY; Ohshima, T; Sawa, M; Takeuchi, Y | 1 |
| Aiguabella, N; Pesquer, A; Riera, A; Verdaguer, X | 1 |
| Hu, Y; Wan, B; Wang, C; Wang, D; Wu, F | 1 |
| Kuang, J; Ma, S; Tang, X | 1 |
| Hügel, HM; Jones, OA | 1 |
| Kano, T; Maruoka, K; Yurino, T | 1 |
| Fan, W; Ma, S | 1 |
| Han, C; Jiang, L; Li, H; Song, M; Sun, Z; Tian, D; Wen, L | 1 |
| Banerjee, P; Chauhan, DP; Talukdar, P; Varma, SJ; Vijeta, A | 1 |
| Au, CT; Chen, T; Chen, X; Han, LB; Yin, SF; Zhou, Y | 1 |
| Hosseini-Sarvari, M; Moeini, F | 1 |
| Alcaide, B; Almendros, P; Alonso, JM; Fernández, I; Gómez-Campillos, G; Torres, MR | 1 |
| Ishida, T; Kobayashi, R; Yamada, T | 1 |
| Barber, QR; Bergh, JJ; Joubert, J; Malan, SF; Petzer, JP; Zindo, FT | 1 |
| Bautista-Aguilera, OM; Esteban, G; Fernández Fernández, AP; Herrero, R; Inokuchi, T; Iriepa, I; Marco-Contelles, J; Moraleda, I; Ojima, M; Romero, A; Samadi, A; Soriano, E; Unzeta, M; Wang, L; Youdim, MB | 1 |
| Keillor, JW; Oteng-Pabi, SK; Pardin, C; Stoica, M | 1 |
| Jiang, H; Li, C; Lizardi, CL; Lu, H; Zhang, XP | 1 |
| Andresen, TL; Clausen, MH; Larsen, TS; Tassone, C; Viart, HM | 1 |
| Hara, Y; Nakamura, S; Ohara, M; Ohnuki, T | 1 |
| Li, P; Peng, Y; Shen, Q; Song, G; Wang, J | 1 |
| Bathini, T; Govardan, S; Rawat, VS; Sreedhar, B | 1 |
| Abbiati, G; Caselli, A; Dell'Acqua, M; Gallo, E; Pedrazzini, T; Pirovano, V; Rossi, E; Trose, M | 1 |
| Chen, J; Dushin, RG; Properzi, R; Starr, JT; Uccello, DP; Young, JA | 1 |
| Polindara-García, LA; Vazquez, A | 1 |
| Dethe, DH; Ranjan, A; Wakchaure, PB; Yerande, R; Yerande, SG | 1 |
| Tong, S; Wang, MX; Wang, Q; Zhu, J | 1 |
| Anglin, BL; Elshan, NG; Jayasundera, T; Lynch, RM; Mash, EA; Weber, CS | 1 |
| Kore, AR; Senthilvelan, A; Shanmugasundaram, M | 1 |
| Balogh, B; Chai, CL; Chua, YY; Deme, R; Gölöncsér, F; Ho, HK; Huleatt, PB; Khoo, ML; Liew, RS; Magyar, K; Mátyus, P; Sheela, DP; Sperlágh, B; Tan, TW | 1 |
| Hua, R; Liu, H; Su, J | 1 |
| Chen, H; Chen, M; Li, S; Liu, J; Liu, Y; Sun, N; Sun, R; Xie, X; Yang, S; You, X | 1 |
| Huang, L; Li, J; Li, X; Mao, F; Wei, H | 1 |
| Castagnolo, D; Chachignon, H; Petricci, E; Scalacci, N | 1 |
| Lei, J; Wu, X; Zhu, Q | 1 |
| Joubert, J; Malan, SF; Zindo, FT | 1 |
| Deng, JR; Shao, SP; Wei, XQ; Wong, KF; Wong, MK; Xiang, DP | 1 |
| De Munck, L; Monleón, A; Muñoz, MC; Pedro, JR; Vila, C | 1 |
| Bartl, F; Brzezinski, B; Huczyński, A; Katrusiak, A; Ratajczak-Sitarz, M; Rutkowski, J | 1 |
| Cheng, G; Cui, X; Weng, Y; Yang, X | 1 |
| Bretschneider, L; Fardim, P; Heinze, T; Näreoja, T; Vega, B; Wondraczek, H | 1 |
| Baranyi, M; Chai, CL; Dunkel, P; Frau, L; Gölöncsér, F; Huleatt, PB; Khoo, ML; Kittel, Á; Kulcsár, S; Mátyus, P; Morelli, M; Otrokocsi, L; Pinna, A; Porceddu, PF; Sperlágh, B | 1 |
| Aragão-Leoneti, V; Carvalho, I; Field, RA; Mantoani, SP; Nepogodiev, SA; Rugen, MD; Zamoner, LO | 1 |
| Del Pino, J; Marco-Contelles, J; Ramos, E; Romero, A | 1 |
| Chiappe, C; Della Ca', N; Gabriele, B; Mancuso, R; Maner, A; Pomelli, C; Veltri, L; Ziccarelli, I | 1 |
| Chen, MW; Chen, ZP; Shi, L; Wu, B; Zhou, YG | 1 |
| Aprile, S; Bellucci, C; Canavesi, R; Del Grosso, E; Grosa, G; Matucci, R | 1 |
| Borchert, P; Goskowitz, S; Jung, M; Klaß, M; Michalek, C; Praetorius, L; Schmidtkunz, K; Schultheisz, P; Schwarzbich, S; Senger, J; Sewald, N; Sippl, W; Wünsch, M | 1 |
| Dong, SN; Gong, Q; Li, J; Li, XK; Liu, WW; Mao, F; Tang, Y; Wang, H; Wang, TD; Xu, YX; Zhang, HY; Zhu, J | 1 |
| López-Muñoz, F; Marco-Contelles, J; Ramos, E; Romero, A | 1 |
| Hocek, M; Matyašovský, J; Pohl, R | 1 |
| Iglesias, MJ; López-Ortiz, F; Navarro, Y; Soengas, R | 1 |
| Ekpo, OE; Enogieru, AB; Joubert, J; Malan, SF; Omoruyi, SI; Zindo, FT | 1 |
| Jain, SL; Panwar, V | 1 |
| Mo, JN; Su, J; Zhao, J | 1 |
| Elhampour, A; Nemati, F; Shahamat, Z | 1 |
| Saeeng, R; Sirion, U; Sutcharitruk, W | 1 |
| Meschaninova, MI; Novopashina, DS; Semikolenova, OA; Silnikov, VN; Venyaminova, AG | 1 |
| do Carmo Carreiras, M; Ismaili, L; Marco-Contelles, J | 1 |
| Gurjar, KK; Kaur, P; Kumar, B; Kumar, R; Kumar, V | 1 |
| Nguyen, VT; Pandith, A; Seo, YJ | 1 |
| Casini, A; Thomas, SR | 1 |
| Khare, NK; Thakur, K | 1 |
| Cao, M; Chan, JZ; Wasa, M; Yesilcimen, A; Zhang, B; Zhang, Y | 1 |
| Liu, S; Luo, J; Luo, ZQ; Ouyang, S; Qiu, J; Zhen, X | 1 |
| Hu, R; Li, W; Tang, BZ; Wu, X | 1 |
| Dodd, CJ; Hill, HM; Jolly, CS; Kochanowski, E; Post, SJ; Turlington, M | 1 |
| Kim, RQ; Mons, E; Mulder, MPC; Ovaa, H; van Doodewaerd, BR; van Veelen, PA | 1 |
| Deng, H; He, Y; Liang, Y; Wu, H; Xiang, L; Xu, Q; Zhang, J | 1 |
| Chairoungdua, A; Pruksakorn, D; Saeeng, R; Silalai, P; Suksen, K | 1 |
| Bai, R; Ge, J; Guo, J; Jiang, X; Xie, Y; Yao, C; Zhang, C; Zhang, J; Zhang, Y; Zhong, Z; Zhou, T | 1 |
| Chen, D; Liu, B; Lorenz, S; Lowe, ED; Nair, RM; Seenivasan, A | 1 |
| Alcaro, S; Ambrož, M; Borges, F; Krátký, M; Maruca, A; Pflégr, V; Rocca, R; Silva, TB; Štěpánková, Š; Svrčková, K; Vinšová, J; Vu, QA | 1 |
| Chuang, JY; Liou, JP; Mehndiratta, S; Qian, B; Shih, JC | 1 |
| Bai, R; Ge, J; Jiang, X; Liu, Z; Xie, T; Xie, Y; Yao, C; Ye, XY; Zhao, R; Zhong, Z; Zhu, J | 1 |
| Chertov, AY; Golovanov, AA; Grigor'eva, OB; Odin, IS | 1 |
| Cui, JF; Huang, LW; O, WY; Wong, MK; Yang, B; Yu, Q | 1 |
| Jin, HS; Wang, RB; Yi, MH; Zhao, LM | 1 |
| Legoabe, LJ; Meiring, L; Petzer, A; Petzer, JP | 1 |
| Mal, P; Mathuri, A; Pramanik, M | 1 |
| Borges, F; Carneiro, A; Matos, MJ; Uriarte, E | 1 |
| Dinc, M; Ismailoglu, E; Kaya, K; Mert, Z; Tayanc, M; Yucel, B | 1 |
18 review(s) available for pargyline and propargylamine
| Article | Year |
|---|---|
[Studies on endogenous toxins as pathogenic factors in idiopathic parkinson's disease].
Topics: Aging; Animals; Apoptosis; Dopamine; Humans; Methyltransferases; Mitochondria; Neurotoxins; Pargyline; Parkinson Disease; Propylamines; Salsoline Alkaloids; Tetrahydroisoquinolines | 2000 |
Maintaining mitochondrial membrane impermeability. an opportunity for new therapy in glaucoma?
Topics: Animals; Apoptosis; bcl-X Protein; Brimonidine Tartrate; Cell Membrane Permeability; Glaucoma; Humans; Intraocular Pressure; Mitochondria; Pargyline; Propylamines; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Retinal Ganglion Cells; Signal Transduction | 2001 |
Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.
Topics: Aging; Animals; Catalase; Free Radical Scavengers; Humans; Life Expectancy; Neuroprotective Agents; Pargyline; Propylamines; Selegiline; Superoxide Dismutase | 2002 |
Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Glyceraldehyde-3-Phosphate Dehydrogenases; HSP70 Heat-Shock Proteins; Humans; Monoamine Oxidase; Neurons; Neuroprotective Agents; Pargyline; Parkinson Disease; Propylamines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Selegiline; Superoxide Dismutase | 2003 |
Advances in neuroprotection research for neurodegenerative diseases.
Topics: Animals; Dopamine Agonists; Estradiol; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Pargyline; Propylamines | 2004 |
Preclinical evidence for neuroprotection with monoamine oxidase-B inhibitors in Parkinson's disease.
Topics: Amphetamines; Animals; Antiparkinson Agents; Apoptosis; Clinical Trials as Topic; Drug Evaluation, Preclinical; Haplorhini; Humans; Inactivation, Metabolic; Indans; Mice; Mice, Transgenic; Models, Neurological; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Oxepins; Oxidative Stress; Pargyline; Parkinson Disease; Propylamines; Selegiline | 2004 |
Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway.
Topics: Animals; Cell Death; Humans; Indans; Nerve Growth Factors; Neuroprotective Agents; Pargyline; Propylamines; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2005 |
[Molecular mechanisms of the neuroprotective effect of (-)-deprenyl].
Topics: Animals; Antioxidants; Antiparkinson Agents; Apoptosis; Dopamine; Drug Synergism; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Mitochondria; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Pargyline; Phosphotransferases; Poly(ADP-ribose) Polymerases; Propylamines; Selegiline | 2006 |
Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety.
Topics: Amyloid beta-Protein Precursor; Animals; Humans; Indans; Neuroprotective Agents; Pargyline; Propylamines; Signal Transduction; Structure-Activity Relationship | 2006 |
Direct addition of alkynes to imines and related C=N electrophiles: A convenient access to propargylamines.
Topics: Alkynes; Electrons; Imines; Oxidation-Reduction; Pargyline; Propylamines | 2006 |
Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Humans; Mitogen-Activated Protein Kinases; Pargyline; Propylamines; Protein Kinase C | 2010 |
Propargylamine-derived multitarget-directed ligands: fighting Alzheimer's disease with monoamine oxidase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Humans; Ligands; Monoamine Oxidase Inhibitors; Pargyline; Propylamines | 2013 |
Neuroprotective and neurorestorative potential of propargylamine derivatives in ageing: focus on mitochondrial targets.
Topics: Aging; Animals; Brain; Humans; Mitochondria; Neuroprotective Agents; Pargyline; Propylamines | 2016 |
Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond.
Topics: Animals; Drug Discovery; Humans; Models, Molecular; Molecular Targeted Therapy; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Pargyline; Polypharmacology; Propylamines | 2015 |
The Asymmetric A³(Aldehyde⁻Alkyne⁻Amine) Coupling: Highly Enantioselective Access to Propargylamines.
Topics: Aldehydes; Alkynes; Amines; Catalysis; Pargyline; Propylamines; Stereoisomerism | 2019 |
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cholinesterases; Humans; Ligands; Monoamine Oxidase; Neuroprotective Agents; Oxidative Stress; Pargyline; Propylamines | 2020 |
Gold compounds for catalysis and metal-mediated transformations in biological systems.
Topics: Alkynes; Animals; Catalysis; Coordination Complexes; Cycloaddition Reaction; Fluorescent Dyes; Gold; Humans; Hydrogenation; Kinetics; Ligands; Optical Imaging; Oxidation-Reduction; Pargyline; Propylamines; Rhodamines; Substrate Specificity | 2020 |
Propargylamine: an important moiety in drug discovery.
Topics: Drug Discovery; Pargyline; Propylamines | 2023 |
177 other study(ies) available for pargyline and propargylamine
| Article | Year |
|---|---|
Oxidative metabolism of some hydrazine derivatives by rat liver and lung tissue fractions.
Topics: 1,2-Dimethylhydrazine; Animals; Clorgyline; Cytochrome P-450 Enzyme System; Dimethylhydrazines; Hydrazines; Iproniazid; Liver; Lung; Male; Microsomes, Liver; Mitochondria, Liver; Monoamine Oxidase; Oxidation-Reduction; Pargyline; Procarbazine; Propylamines; Rats; Rats, Inbred Strains | 1986 |
Deamination of methylamine by semicarbazide-sensitive amine oxidase in human umbilical artery and rat aorta.
Topics: Amine Oxidase (Copper-Containing); Animals; Aorta; Benzylamines; Clorgyline; Deamination; Humans; In Vitro Techniques; Kinetics; Male; Methylamines; Monoamine Oxidase; Oxidoreductases Acting on CH-NH Group Donors; Pargyline; Propylamines; Rats; Rats, Inbred Strains; Semicarbazides; Umbilical Arteries | 1988 |
Inhibition by aminoacetonitrile and propargylamine of glycine cleavage system from rat brain and liver mitochondria.
Topics: Acetonitriles; Alkynes; Aminoacetonitrile; Animals; Brain; Carbon Dioxide; Glycine; In Vitro Techniques; Kinetics; Male; Mitochondria; Mitochondria, Liver; Pargyline; Propylamines; Rats; Rats, Inbred Strains | 1983 |
Mechanism-based inactivation of porcine kidney diamine oxidase by 1,4-diamino-2-butene.
Topics: Aldehydes; Allylamine; Amine Oxidase (Copper-Containing); Anaerobiosis; Animals; Cadaverine; Enzyme Inhibitors; Hydrogen Peroxide; Kidney; Kinetics; Models, Chemical; Oxidation-Reduction; Pargyline; Propylamines; Putrescine; Pyrroles; Spectrophotometry; Swine | 1995 |
Aminoacetone metabolism by semicarbazide-sensitive amine oxidase in rat aorta.
Topics: Acetone; Amine Oxidase (Copper-Containing); Animals; Aorta; Benzylamines; Enzyme Activation; In Vitro Techniques; Kinetics; Male; Oxidoreductases Acting on CH-NH Group Donors; Pargyline; Propylamines; Pyruvaldehyde; Rats; Rats, Sprague-Dawley; Semicarbazides; Subcellular Fractions | 1995 |
Neuroprotective effects of some monoamine oxidase-B inhibitors against DSP-4-induced noradrenaline depletion in the mouse hippocampus.
Topics: Animals; Benzylamines; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Male; Mice; Monoamine Oxidase Inhibitors; Neurons; Neurotransmitter Uptake Inhibitors; Norepinephrine; Pargyline; Phenelzine; Propylamines; Selegiline; Time Factors | 1994 |
Synthesis and structure-activity relationships of the novel homopropargylamine antimycotics.
Topics: Alkynes; Antifungal Agents; Aspergillus fumigatus; Candida; Microsporum; Molecular Structure; Naphthalenes; Pargyline; Propylamines; Sporothrix; Structure-Activity Relationship; Terbinafine; Trichophyton | 1994 |
Effect of structural modification of alkyl N-propargylamines on the selective inhibition of monoamine oxidase B activity.
Topics: Alkylation; Animals; Mitochondria, Liver; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Rats | 1993 |
Interaction of monoamine oxidase inhibitory drugs with some phospholipids.
Topics: Calorimetry, Differential Scanning; Dimyristoylphosphatidylcholine; Drug Interactions; Monoamine Oxidase Inhibitors; Pargyline; Phosphatidic Acids; Phosphatidylethanolamines; Phospholipids; Propylamines; Temperature | 1993 |
Evaluation of HPLC retention data by non-linear mapping, cluster analysis and varimax rotation. A comparative study.
Topics: beta-Cyclodextrins; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cluster Analysis; Cyclodextrins; Furans; Molecular Structure; Monoamine Oxidase Inhibitors; Multivariate Analysis; Pargyline; Propylamines; Regression Analysis | 1996 |
Use of principal component analysis for the evaluation of the retention behaviour of monoamine oxidase inhibitory drugs on beta-cyclodextrin column.
Topics: beta-Cyclodextrins; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cyclodextrins; Food Additives; Monoamine Oxidase Inhibitors; Multivariate Analysis; Pargyline; Propylamines; Solubility | 1995 |
Inversion of selectivity of N-substituted propargylamine monoamine oxidase inhibitors following structural modifications to quaternary salts.
Topics: Amino Acid Sequence; Animals; Isoenzymes; Kinetics; Mitochondria, Liver; Molecular Sequence Data; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Rats; Structure-Activity Relationship | 1999 |
Systemic administration of the propargylamine CGP 3466B prevents behavioural and morphological deficits in rats with 6-hydroxydopamine-induced lesions in the substantia nigra.
Topics: Animals; Antibodies; Apoptosis; Behavior, Animal; Body Weight; Denervation; Dopamine; Exploratory Behavior; Gait; Male; Maze Learning; Nerve Degeneration; Neurons; Oxepins; Oxidopamine; Pargyline; Parkinson Disease, Secondary; Propylamines; Rats; Rats, Wistar; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2000 |
Mechanism underlying anti-apoptotic activity of a (-)deprenyl-related propargylamine, rasagiline.
Topics: Animals; Apoptosis; Humans; Indans; Molecular Structure; Molsidomine; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Pargyline; Propylamines; Rats; Rats, Inbred F344; Selegiline; Tumor Cells, Cultured | 2000 |
Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl.
Topics: Age Factors; Animals; Brain; Catalase; Dogs; Dopamine; Dose-Response Relationship, Drug; Longevity; Mice; Mice, Inbred Strains; Pargyline; Propylamines; Rats; Rats, Inbred Strains; Selegiline; Sex Factors; Superoxide Dismutase | 2000 |
The neuroprotective effects of CGP 3466B in the best in vivo model of Parkinson's disease, the bilaterally MPTP-treated rhesus monkey.
Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Macaca mulatta; Male; Neurons; Neuroprotective Agents; Oxepins; Pargyline; Parkinsonian Disorders; Propylamines | 2000 |
Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.
Topics: Adrenergic Agents; Apoptosis; Cell Line; Humans; Indans; Molsidomine; Neuroprotective Agents; Nitric Oxide Donors; Oxidopamine; Pargyline; Propylamines; Stereoisomerism | 2001 |
Novel intramolecular rearrangement of tertiary propargylamine N-oxides.
Topics: Deuterium; Molecular Structure; Monoamine Oxidase Inhibitors; Oxides; Pargyline; Propylamines; Solvents | 2001 |
Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Survival; Culture Media; Culture Media, Serum-Free; Nerve Growth Factor; Pargyline; PC12 Cells; Propylamines; Protein Synthesis Inhibitors; Rats | 2002 |
Enantioselective direct-addition of terminal alkynes to imines catalyzed by copper(I)pybox complex in water and in toluene.
Topics: Alkynes; Catalysis; Copper; Imines; Organometallic Compounds; Pargyline; Propylamines; Stereoisomerism; Toluene; Water | 2002 |
Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U.
Topics: Azo Compounds; Deoxyribonuclease I; Deoxyuridine; DNA; DNA Footprinting; Fluorescein; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligonucleotides; Pargyline; Propylamines; Spectrometry, Fluorescence; Ultraviolet Rays | 2002 |
Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Butyrylcholinesterase; Carbamates; Cattle; Cholinesterase Inhibitors; Humans; Indans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Propylamines; Structure-Activity Relationship | 2002 |
Novel iminium ion equivalents prepared through C-H oxidation for the stereocontrolled synthesis of functionalized propargylic amine derivatives.
Topics: Amination; Amines; Imines; Oxidation-Reduction; Pargyline; Propylamines; Stereoisomerism; Thiazines | 2003 |
Iterative oxazole assembly via alpha-chloroglycinates: total synthesis of (-)-muscoride A.
Topics: Anti-Infective Agents; Cyclization; Oxazoles; Pargyline; Propylamines; Pyrrolidines; Stereoisomerism; Vitamin B 12 | 2003 |
Highly potent propargylamine and allylamine inhibitors of bovine plasma amine oxidase.
Topics: Allylamine; Amine Oxidase (Copper-Containing); Animals; Binding Sites; Blood Proteins; Cattle; Enzyme Inhibitors; Humans; Metalloproteins; Molecular Structure; Pargyline; Plasma; Propylamines; Time Factors | 2003 |
Synthesis of enantiomerically enriched propargylamines by copper-catalyzed addition of alkynes to enamines.
Topics: Alkynes; Amines; Catalysis; Copper; Crystallography, X-Ray; Molecular Structure; Pargyline; Propylamines; Stereoisomerism | 2003 |
Enantioselective synthesis of propargylamines through Zr-catalyzed addition of mixed alkynylzinc reagents to arylimines.
Topics: Acylation; Alkynes; Amino Acids; Aniline Compounds; Catalysis; Imines; Ligands; Oxidation-Reduction; Pargyline; Propylamines; Stereoisomerism; Zirconium | 2003 |
Three-component enantioselective synthesis of propargylamines through Zr-catalyzed additions of alkyl zinc reagents to alkynylimines.
Topics: Catalysis; Imines; Molecular Structure; Organometallic Compounds; Pargyline; Propylamines; Stereoisomerism; Zinc; Zirconium | 2003 |
The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antiparkinson Agents; Cell Line, Tumor; Indans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Models, Biological; Neuroprotective Agents; Pargyline; PC12 Cells; Peptide Fragments; Propylamines; Protein Processing, Post-Translational; Rats; Structure-Activity Relationship | 2003 |
TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates.
Topics: Animals; Corpus Striatum; Dihydroxyphenylalanine; Macaca mulatta; Male; Motor Skills Disorders; MPTP Poisoning; Pargyline; Propylamines | 2003 |
Neuroprotection by monoamine oxidase B inhibitors: a therapeutic strategy for Parkinson's disease?
Topics: Animals; Apoptosis; Enzyme Inhibitors; Humans; Indans; Models, Chemical; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Neurotoxins; Pargyline; Parkinson Disease; Propylamines; Time Factors | 2004 |
Selective inhibition of bovine plasma amine oxidase by homopropargylamine, a new inactivator motif.
Topics: Aldehydes; Alkylation; Amine Oxidase (Copper-Containing); Amines; Amino Acid Motifs; Animals; Binding Sites; Cattle; Coenzymes; Enzyme Activation; Enzyme Inhibitors; Mercaptoethanol; Mitochondria, Liver; Models, Chemical; Pargyline; Plasma; Propylamines; Rats; Thiocholine; Time Factors | 2004 |
Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation.
Topics: Allylamine; Amine Oxidase (Copper-Containing); Animals; Arthrobacter; Cattle; Coenzymes; Crystallography, X-Ray; Diamines; Dihydroxyphenylalanine; Enzyme Inhibitors; Horses; Naphthalenes; Pargyline; Pichia; Pisum sativum; Propylamines; Protein-Lysine 6-Oxidase; Quinones | 2004 |
The mechanism of nitrogenase. Computed details of the site and geometry of binding of alkyne and alkene substrates and intermediates.
Topics: Alkenes; Alkynes; Allyl Compounds; Amines; Models, Molecular; Molybdoferredoxin; Nitrogenase; Pargyline; Propanols; Propylamines; Protein Conformation; Structure-Activity Relationship | 2004 |
Helical polymer carrying helical grafts from peptide-based acetylene macromonomers: synthesis.
Topics: Acetylene; Alanine; Anhydrides; Circular Dichroism; Glutamic Acid; Methylene Chloride; Pargyline; Peptides; Polymers; Propylamines; Solvents | 2004 |
Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases.
Topics: Animals; Brain; Drug Delivery Systems; In Vitro Techniques; Indans; Iron Chelating Agents; Male; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Neuroprotective Agents; Pargyline; Parkinson Disease; Piperazines; Propylamines; Quinolines; Rats; Rats, Sprague-Dawley | 2004 |
An efficient synthesis of propargylamines via C-H activation catalyzed by copper(I) in ionic liquids.
Topics: Aldehydes; Alkynes; Amines; Catalysis; Copper; Ionic Liquids; Molecular Structure; Pargyline; Propylamines; Stereoisomerism | 2005 |
Synthesis of heterocyclic allenes via palladium-catalyzed hydride-transfer reaction of propargylic amines.
Topics: Alkenes; Catalysis; Cyclization; Heterocyclic Compounds; Hydrogen; Molecular Structure; Oxidation-Reduction; Palladium; Pargyline; Propylamines | 2005 |
Electrostatic stabilization in a pre-organized polar active site: the catalytic role of Lys-80 in Candida tenuis xylose reductase (AKR2B5) probed by site-directed mutagenesis and functional complementation studies.
Topics: Aldehyde Reductase; Binding Sites; Candida; Catalysis; Gene Expression Regulation, Fungal; Genetic Complementation Test; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Mutation; NADP; Oxidation-Reduction; Pargyline; Propylamines; Protein Binding; Static Electricity; Substrate Specificity; Xylitol; Xylose | 2005 |
N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Dose-Response Relationship, Drug; Humans; Mitochondria; Mitochondrial Membranes; Neuroprotective Agents; Pargyline; Propylamines; Proto-Oncogene Proteins c-bcl-2; Salsoline Alkaloids; Tetrahydroisoquinolines; Tumor Cells, Cultured | 2006 |
A Re(V)-catalyzed C-N bond-forming route to human lipoxygenase inhibitors.
Topics: Catalysis; Combinatorial Chemistry Techniques; Humans; Lipoxygenase Inhibitors; Molecular Structure; Organometallic Compounds; Pargyline; Propylamines; Pyrroles; Rhenium; Stereoisomerism; Structure-Activity Relationship | 2005 |
Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine.
Topics: Amyloid beta-Protein Precursor; Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; bcl-Associated Death Protein; Brain-Derived Neurotrophic Factor; Caspase 3; Caspases; Cell Line, Tumor; Cell Survival; DNA Primers; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Humans; Immunoblotting; Indans; Isoelectric Point; Membrane Proteins; Models, Biological; Molecular Sequence Data; Nerve Growth Factors; Neurons; Pargyline; Poly(ADP-ribose) Polymerases; Propylamines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2005 |
Practical highly enantioselective synthesis of propargylamines through a copper-catalyzed one-pot three-component condensation reaction.
Topics: Aldehydes; Alkynes; Amines; Bromides; Catalysis; Copper; Pargyline; Propylamines; Stereoisomerism | 2006 |
Gold(III) Salen complex-catalyzed synthesis of propargylamines via a three-component coupling reaction.
Topics: Artemisinins; Catalysis; Cell Line, Tumor; Drug Screening Assays, Antitumor; Gold; Humans; Inhibitory Concentration 50; Lactones; Molecular Structure; Pargyline; Propylamines; Sesquiterpenes; Stereoisomerism | 2006 |
Antioxidant properties of propargylamine derivatives: assessment of their ability to scavenge peroxynitrite.
Topics: Antioxidants; Dose-Response Relationship, Drug; Free Radical Scavengers; Pargyline; Peroxynitrous Acid; Propylamines | 2006 |
Zinc- and indium-promoted conjugate addition-cyclization reactions of ethenetricarboxylates with propargylamines and alcohol: novel methylenepyrrolidine and methylenetetrahydrofuran syntheses.
Topics: Alkynes; Cyclization; Ethylenes; Furans; Indium; Pargyline; Propanols; Propylamines; Pyrrolidines; Tricarboxylic Acids; Zinc | 2006 |
Highly enantioselective access to primary propargylamines: 4-piperidinone as a convenient protecting group.
Topics: Aldehydes; Alkynes; Catalysis; Molecular Structure; Pargyline; Piperidones; Propylamines; Stereoisomerism | 2006 |
Rationale for considering that propargylamines might be neuroprotective in Parkinson's disease.
Topics: Clinical Trials as Topic; Evidence-Based Medicine; Humans; Indans; Neuroprotective Agents; Pargyline; Parkinson Disease; Practice Guidelines as Topic; Practice Patterns, Physicians'; Propylamines; Selegiline; Treatment Outcome | 2006 |
Asymmetric synthesis of alpha,alpha-dibranched propargylamines by acetylide additions to N-tert-butanesulfinyl ketimines.
Topics: Chemistry, Organic; Pargyline; Propylamines; Stereoisomerism; Sulfonium Compounds | 2006 |
Synthesis of 3-miktoarm stars and 1st generation mikto dendritic copolymers by "living" radical polymerization and "click" chemistry.
Topics: Acrylates; Dendrimers; Magnetic Resonance Spectroscopy; Pargyline; Polystyrenes; Propylamines | 2006 |
EPR studies of amine radical cations. Part 2. Thermal and photo-induced rearrangements of propargylamine and allylamine radical cations in low-temperature freon matrices.
Topics: Algorithms; Allylamine; Cations; Chlorofluorocarbons, Methane; Electron Spin Resonance Spectroscopy; Free Radicals; Kinetics; Light; Molecular Structure; Pargyline; Propylamines; Temperature | 2006 |
Efficient ruthenium and copper cocatalzyed five-component coupling to form dipropargyl amines under mild conditions in water.
Topics: Alkynes; Catalysis; Copper; Imines; Models, Chemical; Pargyline; Propylamines; Ruthenium; Water | 2007 |
A RSK kinase inhibitor reporting its selectivity in vivo.
Topics: Drug Design; Enzyme Inhibitors; Pargyline; Propylamines; Ribosomal Protein S6 Kinases; Substrate Specificity | 2007 |
Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers.
Topics: Benzylamines; Cyclization; Dendrimers; Hydroxy Acids; Pargyline; Polyesters; Propionates; Propylamines | 2007 |
Diastereoselective alkynylation of N-p-tolylsulfinylimines with aluminum acetylides.
Topics: Alkynes; Aluminum; Imines; Lithium; Molecular Structure; Organometallic Compounds; Pargyline; Propylamines; Stereoisomerism; Sulfoxides | 2007 |
Neuroprotection by propargylamines in Parkinson's disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers.
Topics: Alkynes; Cell Death; Cell Line, Tumor; Energy Metabolism; Genetic Markers; Glial Cell Line-Derived Neurotrophic Factor; Humans; Indans; Membrane Potentials; Mitochondria; Neuroblastoma; Neuroprotective Agents; NF-kappa B; Oligonucleotide Array Sequence Analysis; Pargyline; Parkinson Disease; Propylamines; Proto-Oncogene Proteins c-bcl-2; Selegiline | 2007 |
Gold-catalyzed highly enantioselective synthesis of axially chiral allenes.
Topics: Alkadienes; Artemisinins; Catalysis; Gold; Molecular Structure; Pargyline; Propylamines; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2008 |
Enantioselective copper-catalyzed propargylic amination.
Topics: Amination; Catalysis; Copper; Pargyline; Propylamines; Stereoisomerism | 2008 |
A highly efficient and selective Au(I)-catalyzed tandem synthesis of diversely substituted pyrrolo[1,2-a]quinolines in aqueous media.
Topics: Catalysis; Cyclization; HeLa Cells; Humans; Organogold Compounds; Pargyline; Propylamines; Pyrroles; Quinolines; Water | 2008 |
Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H(2)O(2) release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria.
Topics: Animals; Brain; Cells, Cultured; Clorgyline; Electron Transport Complex I; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mitochondria; Monoamine Oxidase Inhibitors; Oxygen; Pargyline; Propylamines; Rats; Succinic Acid | 2008 |
TVP1022 and propargylamine protect neonatal rat ventricular myocytes against doxorubicin-induced and serum starvation-induced cardiotoxicity.
Topics: Animals; Animals, Newborn; Antibiotics, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Cardiotonic Agents; Caspase 3; Cell Line, Tumor; Cells, Cultured; Doxorubicin; Female; Heart Diseases; Heart Ventricles; Humans; Indans; Myocytes, Cardiac; Pargyline; Propylamines; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2008 |
Synthesis of diacetylene-containing peptide building blocks and amphiphiles, their self-assembly and topochemical polymerization in organic solvents.
Topics: Acetylene; Circular Dichroism; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Microscopy, Atomic Force; Molecular Weight; Oligopeptides; Pargyline; Polymers; Propylamines; Solvents; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Surface-Active Agents | 2009 |
Chemoselective C-H bond activation: ligand and solvent free iron-catalyzed oxidative C-C cross-coupling of tertiary amines with terminal alkynes. Reaction scope and mechanism.
Topics: Alkynes; Amines; Catalysis; Ferrous Compounds; Molecular Structure; Oxidation-Reduction; Pargyline; Propylamines | 2009 |
Three-component synthesis of N-Boc-4-iodopyrroles and sequential one-pot alkynylation.
Topics: Alkylation; Catalysis; Combinatorial Chemistry Techniques; Hydrocarbons, Iodinated; Molecular Structure; Palladium; Pargyline; Propylamines; Pyrroles | 2009 |
Iron(III)-catalyzed and air-mediated tandem reaction of aldehydes, alkynes and amines: an efficient approach to substituted quinolines.
Topics: Aldehydes; Alkynes; Amines; Catalysis; Ferric Compounds; Molecular Structure; Pargyline; Propylamines; Quinolines | 2009 |
Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease.
Topics: Apoptosis; Clinical Trials as Topic; Dopamine; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; NF-kappa B; Pargyline; Parkinson Disease; Propylamines; Signal Transduction | 2009 |
Zn(II)-Catalyzed synthesis of piperidines from propargyl amines and cyclopropanes.
Topics: Catalysis; Combinatorial Chemistry Techniques; Cyclization; Cyclopropanes; Molecular Structure; Pargyline; Piperidines; Propylamines; Zinc | 2009 |
Total synthesis of pentabromo- and pentachloropseudilin, and synthetic analogues--allosteric inhibitors of myosin ATPase.
Topics: Allosteric Regulation; Binding Sites; Catalysis; Computer Simulation; Crystallography, X-Ray; Cyclization; Dictyostelium; Hydrocarbons, Chlorinated; Hydrocarbons, Halogenated; Molecular Conformation; Myosins; Pargyline; Propylamines; Pyrroles; Silver | 2009 |
Highly selective fluorescent probe for Au3+ based on cyclization of propargylamide.
Topics: Alkynes; Cations; Colorimetry; Cyclization; Fluorescent Dyes; Gold; Pargyline; Propylamines; Rhodamines | 2009 |
Silver(I)-mediated highly enantioselective synthesis of axially chiral allenes under thermal and microwave-assisted conditions.
Topics: Alkadienes; Catalysis; Microwaves; Pargyline; Propylamines; Silver; Stereoisomerism; Temperature | 2010 |
Copper-catalyzed enantioselective three-component synthesis of optically active propargylamines from aldehydes, amines, and aliphatic alkynes.
Topics: Aldehydes; Alkynes; Amines; Catalysis; Copper; Molecular Structure; Pargyline; Propylamines; Stereoisomerism | 2010 |
A versatile synthetic platform based on strained propargyl amines.
Topics: Alkadienes; Alkynes; Aziridines; Bridged Bicyclo Compounds; Ethers; Pargyline; Propylamines; Stereoisomerism | 2010 |
Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors.
Topics: Animals; Cells, Cultured; Enzyme Inhibitors; Histone Demethylases; Histones; Hydrazines; Pargyline; Peptides; Propylamines; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship | 2010 |
Chiral N-phosphonyl imine chemistry: an efficient asymmetric synthesis of chiral N-phosphonyl propargylamines.
Topics: Imines; Lithium Compounds; Organophosphorus Compounds; Pargyline; Propylamines; Stereoisomerism | 2010 |
Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine.
Topics: Alkynes; Amines; Catalysis; Combinatorial Chemistry Techniques; Copper; Ketones; Microwaves; Molecular Structure; Pargyline; Propylamines | 2010 |
Mechanistic insights into the one-pot synthesis of propargylamines from terminal alkynes and amines in chlorinated solvents catalyzed by gold compounds and nanoparticles.
Topics: Alkynes; Amines; Catalysis; Gold Compounds; Hydrocarbons, Chlorinated; Molecular Structure; Pargyline; Propylamines | 2010 |
Highly diastereoselective synthesis of α-difluoromethyl amines from N-tert-butylsulfinyl ketimines and difluoromethyl phenyl sulfone.
Topics: Amines; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Imines; Molecular Conformation; Molecular Structure; Nitriles; Pargyline; Propylamines; Stereoisomerism; Sulfones; Sulfoxides | 2010 |
A simple method for the preparation of propargylamines using molecular sieve modified with copper(II).
Topics: Aldehydes; Alkynes; Amines; Catalysis; Chemistry, Organic; Copper; Pargyline; Propylamines | 2010 |
Fine-tuning the morphology of self-assembled nanostructures of propargyl ammonium-based amphiphiles.
Topics: Calorimetry, Differential Scanning; Hydrogen-Ion Concentration; Nanostructures; Neutron Diffraction; Pargyline; Propylamines; Quaternary Ammonium Compounds; Scattering, Small Angle | 2010 |
Merging nucleophilic and hydrogen bonding catalysis: an anion binding approach to the kinetic resolution of propargylic amines.
Topics: 4-Aminopyridine; Amides; Anions; Binding Sites; Catalysis; Hydrogen Bonding; Kinetics; Molecular Structure; Pargyline; Propylamines; Stereoisomerism; Thiourea | 2010 |
Star polymers composed entirely of amino acid building blocks: a route towards stereospecific, biodegradable and hierarchically functionalized stars.
Topics: Amino Acids; Biocompatible Materials; Click Chemistry; Drug Carriers; Pargyline; Polymers; Propylamines; Pyrenes | 2011 |
Electrochemical impedance spectroscopy sensor for ascorbic acid based on copper(I) catalyzed click chemistry.
Topics: Alkynes; Ascorbic Acid; Azides; Biosensing Techniques; Catalysis; Click Chemistry; Copper; Dielectric Spectroscopy; Ferrous Compounds; Gold; Humans; Metallocenes; Oxidation-Reduction; Pargyline; Propylamines | 2011 |
The marriage of organocatalysis with metal catalysis: access to multisubstituted chiral 2,5-dihydropyrroles by cascade iminium/enamine-metal cooperative catalysis.
Topics: Aldehydes; Catalysis; Imines; Molecular Structure; Organometallic Compounds; Pargyline; Propylamines; Pyrroles | 2011 |
Highly stereoselective synthesis of cis-β-enaminones mediated by diethyl azodicarboxylate.
Topics: Azo Compounds; Carboxylic Acids; Oxidation-Reduction; Pargyline; Propylamines; Stereoisomerism | 2012 |
Efficient iron(III)-catalyzed three-component coupling reaction of alkynes, CH2Cl2 and amines to propargylamines.
Topics: Alkynes; Amines; Catalysis; Ferric Compounds; Methylene Chloride; Pargyline; Propylamines; Spectroscopy, Fourier Transform Infrared | 2012 |
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Heterocyclic Compounds; Humans; Kinetics; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Peptide Fragments; Propylamines; Protein Multimerization; Protein Structure, Secondary; Rats | 2012 |
A robust, efficient, and highly enantioselective method for synthesis of homopropargyl amines.
Topics: Amines; Catalysis; Pargyline; Propylamines; Stereoisomerism | 2012 |
Site-specific protein propargylation using tissue transglutaminase.
Topics: GTP-Binding Proteins; Molecular Structure; Pargyline; Peptides; Propylamines; Protein Glutamine gamma Glutamyltransferase 2; Substrate Specificity; Transglutaminases | 2012 |
Stereoselective intermolecular C-H amination reactions.
Topics: Acetates; Amination; Amines; Benzylamines; Carbon; Catalysis; Hydrogen; Pargyline; Propylamines; Rhodium; Stereoisomerism | 2012 |
Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process.
Topics: Acylation; Kinetics; Pargyline; Propylamines; Solvents; Stereoisomerism; Temperature | 2012 |
Copper/titanium catalysis forms fully substituted carbon centers from the direct coupling of acyclic ketones, amines, and alkynes.
Topics: Alkynes; Amines; Carbon; Catalysis; Copper; Cyclohexanones; Ketones; Pargyline; Propylamines; Titanium | 2012 |
Three-component reaction of propargyl amines, sulfonyl azides, and alkynes: one-pot synthesis of tetrasubstituted imidazoles.
Topics: Alkynes; Azides; Catalysis; Imidazoles; Molecular Structure; Pargyline; Propylamines; Sulfones | 2012 |
Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity.
Topics: Animals; Autoradiography; Brain; Fluorine Radioisotopes; Humans; Macaca fascicularis; Monoamine Oxidase; Pargyline; Positron-Emission Tomography; Propylamines; Radiography | 2013 |
Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Mice; NIH 3T3 Cells; Pargyline; Propylamines; Triterpenes | 2013 |
Tetrasubstituted olefinic xanthene dyes: synthesis via Pd-catalyzed 6-exo-dig cyclization/C-H activation of 2-bromobenzyl-N-propargylamines and solid state fluorescence properties.
Topics: Alkenes; Catalysis; Coloring Agents; Fluorescence; Molecular Structure; Palladium; Pargyline; Propylamines; Xanthenes | 2013 |
Copper(I) halide promoted diastereoselective synthesis of chiral propargylamines and chiral allenes using 2-dialkylaminomethylpyrrolidine, aldehydes, and 1-alkynes.
Topics: Aldehydes; Alkadienes; Alkynes; Copper; Hydrocarbons, Halogenated; Molecular Structure; Pargyline; Propylamines; Pyrrolidines; Stereoisomerism | 2013 |
Rapid one-pot propargylamine synthesis by plasmon mediated catalysis with gold nanoparticles on ZnO under ambient conditions.
Topics: Aldehydes; Alkynes; Amines; Catalysis; Gold; Metal Nanoparticles; Pargyline; Propylamines; Temperature; Zinc Oxide | 2013 |
A depropargylation-triggered fluorescence "turn-on" probe for the detection of Pd2+ based on a bispropargylamine-rhodamine conjugate.
Topics: Cations, Divalent; Fluorescent Dyes; Optical Imaging; Palladium; Pargyline; Propylamines; Rhodamines; Spectrometry, Fluorescence | 2013 |
Synthesis of antitumor-active betulinic acid-derived hydroxypropargylamines by copper-catalyzend mannich reactions.
Topics: Antineoplastic Agents; Betulinic Acid; Catalysis; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Survival; Copper; Drug Design; Humans; Mannich Bases; Molecular Structure; Pargyline; Pentacyclic Triterpenes; Propylamines; Triterpenes | 2013 |
Gold-catalyzed oxidative cyclization of chiral homopropargyl amides: synthesis of enantioenriched γ-lactams.
Topics: Catalysis; Cyclization; Lactams; Molecular Structure; Organogold Compounds; Oxidation-Reduction; Pargyline; Propylamines | 2013 |
Base-catalyzed cyclization of N-sulfonyl propargylamides to sulfonylmethyl-substituted oxazoles via sulfonyl migration.
Topics: Catalysis; Cyclization; Molecular Structure; Oxazoles; Pargyline; Propylamines; Sulfinic Acids | 2013 |
Rh-catalyzed direct enantioselective alkynylation of α-ketiminoesters.
Topics: Amino Acids; Catalysis; Coordination Complexes; Esters; Pargyline; Propylamines; Protons; Rhodium; Stereoisomerism; Temperature | 2013 |
Pauson-Khand adducts of N-Boc-propargylamine: a new approach to 4,5-disubstituted cyclopentenones.
Topics: Alkylation; Cyclopentanes; Fatty Acids, Unsaturated; Molecular Structure; Pargyline; Propylamines; Stereoisomerism | 2013 |
Synthesis of tetrasubstituted pyrroles from terminal alkynes and imines.
Topics: Alkynes; Catalysis; Imines; Molecular Structure; Pargyline; Propylamines; Pyrroles; Stereoisomerism | 2013 |
CuBr for KA(2) reaction: en route to propargylic amines bearing a quaternary carbon center.
Topics: Alkynes; Amines; Bromides; Carbon; Catalysis; Copper; Ketones; Pargyline; Propylamines | 2013 |
Natural product chemistry in action: the synthesis of melatonin metabolites K₁ and K₂.
Topics: Biological Products; Melatonin; Pargyline; Propylamines | 2013 |
Organocatalytic asymmetric synthesis of propargylamines with two adjacent stereocenters: mannich-type reactions of in situ generated C-alkynyl imines with β-keto esters.
Topics: Catalysis; Esters; Imines; Models, Molecular; Molecular Structure; Pargyline; Propylamines; Stereoisomerism | 2013 |
An easily removable stereo-dictating group for enantioselective synthesis of propargylic amines.
Topics: Aldehydes; Alkynes; Amines; Bromine; Catalysis; Copper; Molecular Structure; Pargyline; Propylamines; Pyrrolidines; Stereoisomerism | 2013 |
Fabrication of cysteine-responsive biomimetic single nanochannels by a thiol-yne reaction strategy and their application for sensing in urine samples.
Topics: Biomimetic Materials; Biosensing Techniques; Buffers; Cysteine; Fluorescence; Humans; Hydrogen-Ion Concentration; Ions; Membrane Potentials; Membranes, Artificial; Microscopy, Confocal; Nanopores; Pargyline; Photoelectron Spectroscopy; Polyethylene Glycols; Polyethylene Terephthalates; Potassium Chloride; Propylamines; Ultraviolet Rays; Urine | 2014 |
A 1,3-amino group migration route to form acrylamidines.
Topics: Amidines; Catalysis; Click Chemistry; Copper; Pargyline; Propylamines | 2014 |
Efficient synthesis of propargylamines from terminal alkynes, dichloromethane and tertiary amines over silver catalysts.
Topics: Alkynes; Amines; Catalysis; Mesylates; Methylene Chloride; Molecular Structure; Pargyline; Propylamines | 2014 |
One-pot multi-component route to propargylamines using zinc oxide under solvent-free conditions.
Topics: Aldehydes; Alkynes; Amines; Catalysis; Combinatorial Chemistry Techniques; Ketones; Pargyline; Propylamines; Zinc Oxide | 2014 |
A gold-catalysed imine-propargylamine cascade sequence: synthesis of 3-substituted-2,5-dimethylpyrazines and the reaction mechanism.
Topics: Catalysis; Gold; Imines; Models, Molecular; Pargyline; Propylamines; Pyrazines | 2014 |
Novel method of tetramic acid synthesis: silver-catalyzed carbon dioxide incorporation into propargylic amine and intramolecular rearrangement.
Topics: Carbon Dioxide; Catalysis; Molecular Structure; Pargyline; Propylamines; Pyrrolidinones; Silver; Stereoisomerism | 2014 |
Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents.
Topics: Acetylene; Apoptosis; Calcium Channel Blockers; Calcium Channels, L-Type; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Pargyline; Propylamines; Protein Conformation; Receptors, N-Methyl-D-Aspartate | 2014 |
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Chelating Agents; Cholinesterase Inhibitors; Donepezil; Hep G2 Cells; Humans; Hydroxyquinolines; Indans; Male; Memory; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Piperidines; Propylamines; Rats | 2014 |
Site-specific protein labelling and immobilization mediated by microbial transglutaminase.
Topics: Alkynes; Azides; Catalysis; Copper; Cycloaddition Reaction; Enzymes, Immobilized; Glutamine; Oligopeptides; Pargyline; Propylamines; Proteins; Streptomycetaceae; Substrate Specificity; Transglutaminases | 2014 |
Chemoselective amination of propargylic C(sp³)-H bonds by cobalt(II)-based metalloradical catalysis.
Topics: Alkynes; Amination; Carbon; Catalysis; Cobalt; Coordination Complexes; Hydrogen; Pargyline; Propylamines | 2014 |
Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.
Topics: Chromatography, High Pressure Liquid; Cyclization; Isothiocyanates; Pargyline; Propylamines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazolidines | 2014 |
Direct enantioselective three-component synthesis of optically active propargylamines in water.
Topics: Aldehydes; Alkynes; Amines; Catalysis; Copper; Pargyline; Propylamines; Stereoisomerism; Water | 2014 |
Synthesis of tertiary propargylamines via a rationally designed multicomponent reaction of primary amines, formaldehyde, arylboronic acids and alkynes.
Topics: Alkynes; Amines; Boronic Acids; Catalysis; Formaldehyde; Pargyline; Propylamines; Solvents | 2014 |
Catalyst-free activation of methylene chloride and alkynes by amines in a three-component coupling reaction to synthesize propargylamines.
Topics: Alkynes; Butylamines; Green Chemistry Technology; Methylene Chloride; Molecular Structure; Pargyline; Piperidines; Propylamines; Pyrrolidines | 2014 |
[Silver(I)(pyridine-containing ligand)] complexes as unusual catalysts for A(3)-coupling reactions.
Topics: Aldehydes; Alkynes; Amines; Aniline Compounds; Catalysis; Ketones; Ligands; Molecular Structure; Organometallic Compounds; Pargyline; Propylamines; Silver | 2014 |
One-pot oxidation and rearrangement of propargylamines and in situ pyrazole synthesis.
Topics: Catalysis; Celecoxib; Combinatorial Chemistry Techniques; Molecular Structure; Oxidation-Reduction; Pargyline; Propylamines; Pyrazoles; Sulfonamides | 2014 |
Combinatorial synthesis of nicotine analogs using an Ugi 4-CR/cyclization-reduction strategy.
Topics: Catalysis; Combinatorial Chemistry Techniques; Cyclization; Hydroxybenzoate Ethers; Molecular Structure; Nicotine; Oxidation-Reduction; Palladium; Pargyline; Propylamines; Pyridines; Stereoisomerism | 2014 |
Base-mediated hydroamination of propargylamine: a regioselective intramolecular 5-exo-dig cycloisomerization en route to imidazole-2-thione.
Topics: Catalysis; Cyclization; Ethylenethiourea; Gold; Imidazoles; Molecular Structure; Pargyline; Propylamines; Stereoisomerism; Thiones; Transition Elements | 2014 |
Tuning the reactivity of isocyano group: synthesis of imidazoles and imidazoliums from propargylamines and isonitriles in the presence of multiple catalysts.
Topics: Catalysis; Imidazoles; Isomerism; Mesylates; Nitriles; Organometallic Compounds; Pargyline; Propylamines | 2015 |
Trigonal scaffolds for multivalent targeting of melanocortin receptors.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; HEK293 Cells; Heterocyclic Compounds; Humans; Molecular Structure; Pargyline; Phloroglucinol; Propylamines; Receptors, Melanocortin; Structure-Activity Relationship | 2015 |
Highly regioselective C-5 iodination of pyrimidine nucleotides and subsequent chemoselective Sonogashira coupling with propargylamine.
Topics: DNA; Drug Design; Iodine; Magnetic Resonance Spectroscopy; Nucleotides; Palladium; Pargyline; Phosphates; Propylamines; Pyridines; Pyrimidine Nucleotides; Pyrimidines | 2015 |
Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Mice; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Pargyline; Parkinson Disease; PC12 Cells; Propylamines; Rats; Structure-Activity Relationship | 2015 |
Au(I)-catalyzed annulation of propargyl amine with aldehydes: one-pot cascade synthesis of 2,5-dimethylpyrazines.
Topics: Aldehydes; Combinatorial Chemistry Techniques; Molecular Structure; Organogold Compounds; Pargyline; Propylamines; Pyrazines | 2015 |
Cp2TiCl2-catalyzed cis-hydroalumination of propargylic amines with Red-Al: stereoselective synthesis of Z-configured allylic amines.
Topics: Catalysis; Chemistry Techniques, Synthetic; Models, Molecular; Molecular Conformation; Organometallic Compounds; Pargyline; Propylamines; Stereoisomerism | 2015 |
Tacrine-propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Humans; Molecular Structure; Pargyline; Propylamines; Structure-Activity Relationship; Tacrine | 2015 |
Synthesis of 1,2,3-Substituted Pyrroles from Propargylamines via a One-Pot Tandem Enyne Cross Metathesis-Cyclization Reaction.
Topics: Cyclization; Microwaves; Molecular Structure; Pargyline; Propylamines; Pyrroles | 2015 |
Copper-catalyzed trifluoromethylalkynylation of isocyanides.
Topics: Catalysis; Copper; Cyanides; Hydrocarbons, Fluorinated; Molecular Structure; Pargyline; Propylamines | 2015 |
Visual detection of formaldehyde by highly selective fluorophore labeling via gold(III) complex-mediated three-component coupling reaction.
Topics: Alkynes; Catalysis; Fluorescent Dyes; Formaldehyde; Gold; Pargyline; Propylamines; Spectrometry, Fluorescence; Ultraviolet Rays | 2015 |
Enantioselective alkynylation of benzo[e][1,2,3]-oxathiazine 2,2-dioxides catalysed by (R)-VAPOL-Zn complexes: synthesis of chiral propargylic cyclic sulfamidates.
Topics: Alkynes; Amides; Catalysis; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Ligands; Pargyline; Phenanthrenes; Propanols; Propylamines; Stereoisomerism; Thiazines; Zinc | 2015 |
Spectroscopic studies of the equilibrium between complexes of lasalocid acid with propargylamine and metal cations.
Topics: Cations; Coordination Complexes; Crystallography, X-Ray; Hydrogen Bonding; Ionophores; Lasalocid; Magnetic Resonance Spectroscopy; Metals; Models, Molecular; Pargyline; Propylamines; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared | 2015 |
Base-Promoted N-Pyridylation of Heteroarenes Using N-Propargyl Enaminones as Equivalents of Pyridine Scaffolds.
Topics: Catalysis; Molecular Structure; Pargyline; Peptides; Propylamines; Pyridines; Water | 2015 |
Preparation of reactive fibre interfaces using multifunctional cellulose derivatives.
Topics: Alkynes; Azides; Cellulose; Click Chemistry; Cycloaddition Reaction; Pargyline; Propylamines; Pyrenes; Water | 2015 |
Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Male; Oxidative Stress; Pargyline; Parkinson Disease; Propylamines; Rats, Wistar; Substantia Nigra | 2016 |
CuAAC click chemistry with N-propargyl 1,5-dideoxy-1,5-imino-D-gulitol and N-propargyl 1,6-dideoxy-1,6-imino-D-mannitol provides access to triazole-linked piperidine and azepane pseudo-disaccharide iminosugars displaying glycosidase inhibitory properties.
Topics: 1-Deoxynojirimycin; alpha-Glucosidases; Azides; beta-Amylase; beta-Glucosidase; Click Chemistry; Disaccharides; Enzyme Inhibitors; Glucose; Heterocyclic Compounds, 1-Ring; Hordeum; Imino Sugars; Mannitol; Pargyline; Piperidines; Propylamines; Prunus dulcis; Saccharomyces cerevisiae; Triazoles | 2016 |
Upregulation of Antioxidant Enzymes by ASS234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy.
Topics: Alzheimer Disease; Animals; Catalase; Cholinesterase Inhibitors; Humans; Indoles; Pargyline; Piperidines; Propylamines; Signal Transduction; Superoxide Dismutase-1; Up-Regulation | 2016 |
Auto-Tandem Catalysis in Ionic Liquids: Synthesis of 2-Oxazolidinones by Palladium-Catalyzed Oxidative Carbonylation of Propargylic Amines in EmimEtSO₄.
Topics: Acetamides; Catalysis; Cyclization; Imidazoles; Ionic Liquids; Oxazolidinones; Oxidation-Reduction; Palladium; Pargyline; Propylamines | 2016 |
Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation.
Topics: Biomimetic Materials; Halogenation; Hydrogenation; Molecular Structure; Pargyline; Propylamines | 2016 |
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Glucuronides; Humans; Ketones; Male; Mandelic Acids; Mass Spectrometry; Metabolic Networks and Pathways; Microsomes, Liver; Oxidation-Reduction; Pargyline; Propylamines; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Muscarinic | 2018 |
Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Humans; Molecular Structure; Pargyline; Propylamines; Structure-Activity Relationship | 2017 |
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Discovery; Humans; Imidazoles; Mice; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Pyrimidines; Rats; Scopolamine; Structure-Activity Relationship; Thiourea | 2018 |
In silico assessment of the metabolism and its safety significance of multitarget propargylamine ASS234.
Topics: Computer Simulation; Humans; Indoles; Metabolism; Models, Chemical; Pargyline; Piperidines; Propylamines | 2018 |
2-Allyl- and Propargylamino-dATPs for Site-Specific Enzymatic Introduction of a Single Modification in the Minor Groove of DNA.
Topics: Allyl Compounds; Deoxyadenine Nucleotides; DNA; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Nucleic Acid Conformation; Oligonucleotides; Pargyline; Propylamines | 2018 |
Immobilized Gold Nanoparticles Prepared from Gold(III)-Containing Ionic Liquids on Silica: Application to the Sustainable Synthesis of Propargylamines.
Topics: Catalysis; Gold; Ionic Liquids; Magnetic Resonance Spectroscopy; Metal Nanoparticles; Pargyline; Propylamines; Silicon Dioxide | 2018 |
Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.
Topics: Cell Line, Tumor; Drug Design; Humans; Monoamine Oxidase; Neuroblastoma; Neuroprotective Agents; Pargyline; Propylamines; Protein Binding; Structure-Activity Relationship | 2019 |
Ternary hybrid TiO
Topics: Aldehydes; Alkynes; Aniline Compounds; Catalysis; Gold; Light; Metal Nanoparticles; Pargyline; Photochemistry; Photoelectron Spectroscopy; Propylamines; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Titanium; X-Ray Diffraction | 2019 |
One-pot synthesis of propargylamines using magnetic mesoporous polymelamine formaldehyde/zinc oxide nanocomposite as highly efficient, eco-friendly and durable nanocatalyst: optimization by DOE approach.
Topics: Catalysis; Chemistry Techniques, Synthetic; Formaldehyde; Green Chemistry Technology; Magnets; Nanocomposites; Nanostructures; Pargyline; Porosity; Propylamines; Zinc Oxide | 2020 |
One-pot synthesis of substituted-amino triazole-glycosides.
Topics: Alkylation; Amines; Carbohydrate Sequence; Click Chemistry; Glycosides; Pargyline; Propylamines; Triazoles | 2019 |
Novel Convenient Approach to the Solid-Phase Synthesis of Oligonucleotide Conjugates.
Topics: Boron Compounds; Diamines; Molecular Structure; Oligonucleotides; Pargyline; Propylamines; Pyrenes; Solid-Phase Synthesis Techniques | 2019 |
Metal- and Solvent-Free Multicomponent Decarboxylative A
Topics: Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Solvents; Structure-Activity Relationship | 2020 |
Propargylamine-selective dual fluorescence turn-on method for post-synthetic labeling of DNA.
Topics: Cell Line, Tumor; DNA; Fluorescence; Fluorescent Dyes; Humans; Molecular Structure; Optical Imaging; Pargyline; Propylamines; Staining and Labeling | 2020 |
Copper mediated A
Topics: Copper; Deoxy Sugars; Ligands; Molecular Structure; Pargyline; Proline; Propylamines; Stereoisomerism | 2020 |
Direct Conversion of
Topics: Amines; Catalysis; Copper; Lewis Acids; Molecular Structure; Organometallic Compounds; Pargyline; Propylamines; Stereoisomerism | 2020 |
Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes.
Topics: Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins; Deubiquitinating Enzymes; Legionella pneumophila; Pargyline; Phagosomes; Propylamines; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination; Vacuoles | 2020 |
Catalyst-Free Four-Component Polymerization of Propiolic Acids, Benzylamines, Organoboronic Acids, and Formaldehyde toward Functional Poly(propargylamine)s.
Topics: Alkynes; Benzylamines; Catalysis; Formaldehyde; Pargyline; Polymerization; Propylamines | 2021 |
Diastereoselective Synthesis of Terminal Bromo-Substituted Propargylamines via Generation of Lithium Bromoacetylide and Addition to Chiral
Topics: Imines; Lithium; Pargyline; Propylamines; Stereoisomerism | 2021 |
Exploring the Versatility of the Covalent Thiol-Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease.
Topics: Alkynes; Cysteine Proteases; Deubiquitinating Enzymes; HEK293 Cells; Humans; Pargyline; Propylamines; Sulfhydryl Compounds; Ubiquitin Thiolesterase | 2021 |
Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry.
Topics: Pargyline; Propylamines | 2021 |
Synthesis of propargylamine mycophenolate analogues and their selective cytotoxic activity towards neuroblastoma SH-SY5Y cell line.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Mycophenolic Acid; Neuroblastoma; Pargyline; Propylamines; Structure-Activity Relationship | 2021 |
N-Propargylamine-hydroxypyridinone hybrids as multitarget agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Disease Models, Animal; Drug Design; Drug Stability; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Iron Chelating Agents; Maze Learning; Mice; Mice, Inbred ICR; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Pyridines; Structure-Activity Relationship | 2021 |
Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Topics: Amino Acid Sequence; Catalysis; Catalytic Domain; Cysteine; Humans; Models, Molecular; Pargyline; Propylamines; Protein Conformation; Structure-Activity Relationship; Substrate Specificity; Ubiquitin; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination | 2021 |
Novel propargylamine-based inhibitors of cholinesterases and monoamine oxidases: Synthesis, biological evaluation and docking study.
Topics: Animals; Antioxidants; Butyrylcholinesterase; Cells, Cultured; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Electrophorus; Hepatocytes; Horses; Humans; Male; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Rats; Rats, Wistar; Reactive Oxygen Species; Structure-Activity Relationship | 2021 |
Topics: Acetylation; Animals; Cell Line, Tumor; Cell Proliferation; Drug Design; Enzyme Inhibitors; Glioma; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Isoenzymes; Kaplan-Meier Estimate; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Pargyline; Propylamines; Structure-Activity Relationship; Transplantation, Heterologous | 2022 |
HDAC1/MAO-B dual inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Drug Design; Hydroxamic Acids; Mice; Mice, Inbred ICR; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Structure-Activity Relationship | 2022 |
Ketone Derivatives of Propargylamines as Synthetic Equivalents of Conjugated 2,4,1-Enynones in the Synthesis of Acetylenic 2-Pyrazolines and Pyrazoles.
Topics: Acetylene; Alkynes; Ketones; Pargyline; Propylamines; Pyrazoles | 2022 |
Synthesis of 1
Topics: Catalysis; Cyclization; Diynes; Halogenation; Molecular Structure; Pargyline; Propylamines | 2022 |
Copper-Catalyzed Cascade Annulation of
Topics: Catalysis; Copper; Pargyline; Propylamines; Pyrazoles; Pyrazolones | 2022 |
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.
Topics: Humans; Indans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Propylamines; Selegiline; Tetrahydronaphthalenes; Tyramine | 2022 |
3-Arylsulfonylquinolines from
Topics: Oxidative Stress; Pargyline; Propylamines; Sulfones | 2022 |
Base-Mediated Rearrangement of α-Dithioacetyl Propargylamines via Expansion of Dithioacetyl Ring: Synthesis of Medium-Sized
Topics: Culture Media; Pargyline; Propylamines; Sulfur | 2023 |