pargyline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

pargyline has been researched along with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in 72 studies

Research

Studies (72)

Timeframe	Studies, this research(%)	All Research%
pre-1990	46 (63.89)	18.7374
1990's	22 (30.56)	18.2507
2000's	4 (5.56)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Duchemin, AM; Gudehithlu, KP; Hadjiconstantinou, M; Neff, NH	1
Campbell, KJ; Hattori, T; Takada, M	1
Chacón, JN; Truscott, TG	1
Behmand, RA; Harik, SI; Riachi, NJ	1
Pai, KS; Ravindranath, V	1
Bankiewicz, KS; Crane, AM; Kopin, IJ; Palombo, E; Porrino, LJ; Sokoloff, L	1
Dietrich, WD; Harik, SI; Riachi, NJ	1
Billings, J; Dutta, A; Efange, SM; Freshler, A; Jabir, M; Kung, HF; Mash, DC; Pablo, J	1
Boudreau, RJ; Dutta, AK; Efange, SM; Freshler, A; Michelson, RH; Remmel, RP	1
Basma, AN; Geller, HM; Giovanni, A; Heikkila, RE; Nicklas, WJ	1
Bacon, JP; Hanselman, DS; Johannessen, JN; Markey, CJ; Markey, SP; Savitt, JM; Weisz, A	1
Bacon, JP; Burns, RS; Chiueh, CC; Garrick, NA; Johannessen, JN; Kopin, IJ; Markey, SP; Parisi, JE; Weise, VK	1
Ambrosio, S; Mahy, N	1
Harik, SI; LaManna, JC; Riachi, NJ	1
Kass, GE; Nicotera, P; Orrenius, S; Wright, JM	1
Weight, FF; Wilson, JA; Wilson, JS	1
Galvan, M; Kupsch, A; ten Bruggencate, G	1
Jenner, P; Marsden, CD	1
Cheeseman, AJ; Clark, JB	1
Finberg, JP; Youdim, MB	1
Fuller, RW; Heikkila, RE; Hemrick-Luecke, SK; Kindt, MV	1
Grimm, LJ; Kellar, KJ; Kettler, KG; Perry, DC	1
Mizuno, Y; Saitoh, T; Sone, N; Suzuki, K	1
Larsson, BS; Lindquist, NG; Lydén-Sokolowski, A	1
Harik, SI; Riachi, NJ	1
Lee, EH	1
Carlsson, A; Pileblad, E	1
Fukuda, H; Hara, K; Kameyama, M; Kimura, H; Nakamura, S; Tohyama, I	1
Jonsson, G; Sundström, E	1
Di Monte, D; Ekström, G; Jewell, SA; Sandy, MS; Smith, MT	1
Jonsson, G; Luthman, J	1
Gullberg, P; Hartvig, P; Långström, B; Larsson, BS; Lindberg, BS; Lindquist, NG; Lundqvist, H; Malmborg, P; Oreland, L; Rimland, A	1
DeVito, MJ; Wagner, GC	1
Harik, SI; Kalaria, RN; Mitchell, MJ	1
Irwin, I; Kunis, DM; Langston, JW; Ransom, BR	1
Castagnoli, N; Di Monte, D; Ekström, G; Shinka, T; Smith, MT; Trevor, AJ	1
Bixler, GB; Dunn, AJ; Eaker, EY; Mathias, JR; Moreshead, WV	1
Ofori, S; Schorderet, M	1
Irwin, I; Langston, JW	1
Castagnoli, N; Chiba, K; Trevor, AJ	1
Jarvis, MF; Wagner, GC	1
Fuller, RW; Hemrick-Luecke, SK	1
Barbeau, A; Boyer, H; Buu, NT; Dallaire, L; de Lanney, LE; Irwin, I; Langston, EB; Langston, JW; Veilleux, F	1
Manaker, S; Parsons, B; Rainbow, TC; Wieczorek, CM	1
Manaker, S; Parsons, B; Rainbow, TC; Reznikoff, G; Rhodes, CH	1
Barbeau, A; Buu, NT; Dallaire, L; Poirier, J; Rucinska, E	1
Cohen, G; Mytilineou, C	1
Sirinathsinghji, DJ	1
Bocchetta, A; Corsini, GU; Del Zompo, M; Piccardi, MP; Pintus, S	2
Hirata, Y; Nagatsu, T	1
Duvoisin, RC; Finberg, JP; Heikkila, RE; Youdim, MB	1
Forno, LS; Irwin, I; Langston, EB; Langston, JW	1
Parsons, B; Rainbow, TC	1
Castagnoli, N; Chiba, K; Trevor, A	1
Cohen, B; Cohen, G; Leist, A; Mytilineou, C; Pasik, P; Yahr, MD	1
Boulton, AA; Davis, BA; Yu, PH	1
Ichikawa, Y; Wu, RF	1
Gaál, J; Kardos, V; Kollár, E; Pátfalusi, M; Patthy, M; Singer, J; Solti, M; Sziráki, I	1
Hanani, M; Haskel, Y	1
May, T	1
Barber, A; Boulton, AA; Davis, BA; Durden, DA; Nicklas, WG; Terleckyj, I; Yu, PH	1
Griffiths, H; Lai, M; Lunec, J; Pall, H; Williams, A	1
Hattori, T; Sugimoto, T; Takada, M	1
Bieganowska, K; Czonkowska, A; Korlak, J	1
Bankiewicz, KS; Eberling, JL; Jagust, WJ; Jordan, S; VanBrocklin, HF	1
Członkowska, A; Członkowski, A; Kohutnicka, M; Kurkowska-Jastrzebska, I; Lewandowska, E	1
Akiyama, A; Nakazato, T	1
Araki, T; Ido, T; Imai, Y; Itoyama, Y; Kumagai, T; Matsubara, M	1
Bloomquist, JR; Freeborn, ER; Kirby, ML; Klein, BG	1
Araki, T; Imai, Y; Itoyama, Y; Kato, H; Kurosaki, R; Matsubara, M; Michimata, M; Mikami, T; Muramatsu, Y	1
Hadjiconstantinou, M; Neff, NH; Podell, M; Smith, MA	1

Reviews

3 review(s) available for pargyline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Article	Year
The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease. Journal of neural transmission. Supplementum, 1986, Volume: 20 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Callithrix; Corpus Striatum; Disease Models, Animal; Dopamine; Ergolines; Humans; Levodopa; Macaca mulatta; Neural Pathways; Pargyline; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Quinpirole; Rats; Saimiri; Selegiline; Species Specificity; Substantia Nigra	1986
Aliphatic propargylamines, a new series of potent selective, irreversible non-amphetamine-like MAO-B inhibitors. Their structures, function and pharmacological implications. Advances in experimental medicine and biology, 1995, Volume: 363 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Mice; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Structure-Activity Relationship	1995
Amphetamine-metabolites of deprenyl involved in protection against neurotoxicity induced by MPTP and 2'-methyl-MPTP. Journal of neural transmission. Supplementum, 1994, Volume: 41 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamines; Animals; Corpus Striatum; Dopamine Antagonists; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotoxins; Pargyline; Rats; Rats, Inbred Strains; Selegiline	1994

Other Studies

69 other study(ies) available for pargyline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Article	Year
c-fos mRNA in mouse brain after MPTP treatment. Neurochemistry international, 1992, Volume: 20, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Blotting, Northern; Brain; Dose-Response Relationship, Drug; Genes, fos; Kinetics; Male; Mazindol; Mice; Neurotoxins; Organ Specificity; Pargyline; Reference Values; RNA; RNA, Messenger; Selegiline; Time Factors	1992
Regional localization of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) uptake: mismatch between its uptake and neurotoxic sites. Neuroscience letters, 1991, Nov-25, Volume: 133, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Injections, Intraventricular; Male; Mesencephalon; Motor Neurons; Pargyline; Pyridinium Compounds; Rats; Rats, Inbred Strains; Receptors, Cholinergic	1991
Chemically induced Parkinson's disease. III: A study of a possible role of singlet molecular oxygen in Parkinson's disease. Journal of photochemistry and photobiology. B, Biology, 1991, Volume: 11, Issue:3-4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Free Radicals; Lasers; Monoamine Oxidase; Oxygen; Pargyline; Parkinson Disease; Radiation-Sensitizing Agents; Selegiline	1991
Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains. Brain research, 1991, Jul-26, Volume: 555, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Biogenic Amines; Blood-Brain Barrier; Brain Chemistry; Carotid Arteries; Cerebral Cortex; Corpus Striatum; Dopamine; Injections, Intra-Arterial; Male; Microcirculation; Monoamine Oxidase; MPTP Poisoning; Nervous System Diseases; Oxidation-Reduction; Pargyline; Rats; Rats, Inbred F344; Rats, Inbred Strains; Species Specificity	1991
Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices. Brain research, 1991, Aug-02, Volume: 555, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; MPTP Poisoning; NADPH-Ferrihemoprotein Reductase; Pargyline; Phenobarbital; Piperazines; Piperonyl Butoxide; Proadifen; Selegiline	1991
Cerebral metabolic effects of monoamine oxidase inhibition in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine acutely treated monkeys. Journal of neurochemistry, 1991, Volume: 56, Issue:5 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Brain; Female; Glucose; Macaca mulatta; Male; Monoamine Oxidase Inhibitors; Pargyline; Reference Values	1991
Effects of internal carotid administration of MPTP on rat brain and blood-brain barrier. Brain research, 1990, Nov-12, Volume: 533, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aminoisobutyric Acids; Animals; Biogenic Monoamines; Blood-Brain Barrier; Brain; Capillary Permeability; Carotid Artery, Internal; Endothelium, Vascular; Horseradish Peroxidase; Injections, Intra-Arterial; Male; MPTP Poisoning; Pargyline; Rats; Rats, Inbred Strains; Tritium	1990
Pargyline-sensitive selective accumulation of a radiolabeled MPTP analog in the primate cerebral cortex and basal ganglia. Synapse (New York, N.Y.), 1990, Volume: 5, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Basal Ganglia; Cerebral Cortex; Female; Haplorhini; Image Processing, Computer-Assisted; Pargyline; Phosphothreonine; Threonine	1990
Flexible N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues: synthesis and monoamine oxidase catalyzed bioactivation. Journal of medicinal chemistry, 1990, Volume: 33, Issue:12 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Biotransformation; Brain; Chemical Phenomena; Chemistry; Kinetics; Mitochondria; Molecular Conformation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Substrate Specificity	1990
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells: role of monoamine oxidase A. Journal of neurochemistry, 1990, Volume: 55, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Cell Survival; Clorgyline; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Pargyline; Pheochromocytoma; Pyridinium Compounds; Rats; Tumor Cells, Cultured	1990
The development of amine substituted analogues of MPTP as unique tools for the study of MPTP toxicity and Parkinson's disease. Life sciences, 1987, Feb-23, Volume: 40, Issue:8 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Amines; Animals; Brain Chemistry; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Immunologic Techniques; Male; Mice; Pargyline; Parkinson Disease, Secondary; Pyridines; Serotonin; Structure-Activity Relationship	1987
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the dog: effect of pargyline pretreatment. Journal of neurochemistry, 1989, Volume: 53, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain; Dogs; Dopamine; Female; Male; Monoamine Oxidase; Norepinephrine; Pargyline; Pyridines; Tissue Distribution; Tyrosine 3-Monooxygenase	1989
Acute peripheral catecholaminergic changes in rat after MPTP and MPP+ treatment. Revista espanola de fisiologia, 1989, Volume: 45, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adrenal Medulla; Animals; Heart; Male; Myocardium; Norepinephrine; Pargyline; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Tyrosine 3-Monooxygenase	1989
Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Blood-Brain Barrier; Brain; Butanols; Male; Pargyline; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Tritium	1989
The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium. Archives of biochemistry and biophysics, 1988, Feb-01, Volume: 260, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cell Membrane Permeability; Cell Survival; Cytosol; Liver; Male; Mitochondria; Monoamine Oxidase Inhibitors; Pargyline; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Selegiline	1988
MPTP causes a non-reversible depression of synaptic transmission in mouse neostriatal brain slice. Brain research, 1986, Mar-19, Volume: 368, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Corpus Striatum; Dopamine Antagonists; Electric Stimulation; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neural Inhibition; Pargyline; Piperazines; Pyridines; Pyridinium Compounds; Synapses; Synaptic Transmission	1986
Actions of MPTP and MPP+ on synaptic transmission in guinea-pig hippocampal slices. Experimental neurology, 1987, Volume: 96, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Evoked Potentials; Female; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurotoxins; Pargyline; Pyridines; Pyridinium Compounds; Synaptic Transmission	1987
Effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine and its metabolite 1-methyl-4-phenylpyridine on acetylcholine synthesis in synaptosomes from rat forebrain. Journal of neurochemistry, 1987, Volume: 48, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcholine; Allylamine; Animals; Brain; Citric Acid Cycle; Diencephalon; Glucose; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; NAD(P)H Dehydrogenase (Quinone); Pargyline; Pyridines; Pyridinium Compounds; Quinone Reductases; Rats; Rats, Inbred Strains; Synaptosomes; Telencephalon	1987
MAO type B inhibitors as adjunct to L-dopa therapy. Advances in neurology, 1987, Volume: 45 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkynes; Animals; Brain; Drug Therapy, Combination; Humans; Indans; Isoenzymes; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Receptors, Dopamine; Selegiline; Structure-Activity Relationship; Tyramine	1987
Different effects of monoamine oxidase inhibition on MPTP depletion of heart and brain catecholamines in mice. Life sciences, 1988, Volume: 42, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cyclopropanes; Dopamine; Liver; Male; Mice; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Oxidation-Reduction; Pargyline; Pyridines; Selegiline	1988
[3H]tryptamine binding sites are not identical to monoamine oxidase in rat brain. Journal of neurochemistry, 1988, Volume: 51, Issue:5 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding, Competitive; Brain; Clorgyline; Male; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline; Synaptosomes; Tissue Distribution; Tryptamines	1988
Inhibition of mitochondrial respiration by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse brain in vivo. Neuroscience letters, 1988, Sep-12, Volume: 91, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Citric Acid Cycle; Malate Dehydrogenase; Male; Mice; Mice, Inbred C57BL; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Pargyline; Pyridines; Quinone Reductases; Time Factors	1988
Disposition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice before and after monoamine oxidase and catecholamine reuptake inhibition. Pharmacology & toxicology, 1988, Volume: 63, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Glands; Animals; Autoradiography; Brain; Catecholamines; Clorgyline; Female; Image Processing, Computer-Assisted; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Nomifensine; Pargyline; Pyridines; Scintillation Counting; Selegiline; Tissue Distribution	1988
Strain differences in systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in mice correlate best with monoamine oxidase activity at the blood-brain barrier. Life sciences, 1988, Volume: 42, Issue:23 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Blood-Brain Barrier; Brain; Cerebral Cortex; Corpus Striatum; Dopamine; Male; Mice; Mice, Inbred C57BL; Microcirculation; Monoamine Oxidase; Pargyline; Pyridines; Species Specificity; Tritium	1988
Neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on striatal biopterin in BALB/c mice. Neuroscience letters, 1988, Jun-07, Volume: 88, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biopterins; Corpus Striatum; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Neurotoxins; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Species Specificity	1988
Studies on the acute and long-term changes in dopamine and noradrenaline metabolism in mouse brain following administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Pharmacology & toxicology, 1988, Volume: 62, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Brain Chemistry; Dopamine; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Norepinephrine; Pargyline; Pyridines; Time Factors	1988
Reversible serotoninergic neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse striatum studied by neurochemical and immunohistochemical approaches. Brain research, 1987, May-05, Volume: 410, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain Chemistry; Corpus Striatum; Dopamine; Histocytochemistry; Immunologic Techniques; Male; Mice; Mice, Inbred ICR; Pargyline; Pyridines; Serotonin; Time Factors	1987
Differential time course of protection by monoamine oxidase inhibition and uptake inhibition against MPTP neurotoxicity on central catecholamine neurons in mice. European journal of pharmacology, 1986, Mar-18, Volume: 122, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Catecholamines; Male; Mice; Monoamine Oxidase Inhibitors; Neurons; Nomifensine; Pargyline; Pyridines; Time Factors	1986
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes. Biochemical and biophysical research communications, 1986, May-29, Volume: 137, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Carmustine; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; In Vitro Techniques; Liver; Male; Pargyline; Pyridines; Pyridinium Compounds; Rats; Time Factors	1986
Effects of the parkinsonism-inducing neurotoxin MPTP and its metabolite MPP+ on sympathetic adrenergic nerves in mouse iris and atrium. Medical biology, 1986, Volume: 64, Issue:2-3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adrenergic Fibers; Animals; Biological Transport, Active; Desipramine; Heart; Iris; Male; Mice; Nerve Degeneration; Norepinephrine; Pargyline; Pyridines; Pyridinium Compounds	1986
Influence of monoamine oxidase inhibitors and a dopamine uptake blocker on the distribution of 11C-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 11C-MPTP, in the head of the rhesus monkey. Acta neurologica Scandinavica, 1986, Volume: 74, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Clorgyline; Eye; Female; Macaca mulatta; Nomifensine; Pargyline; Propylamines; Pyridines; Temporal Muscle; Tomography, Emission-Computed	1986
Pargyline and naltrexone fail to antagonize the gustatory avoidance response induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Drug and alcohol dependence, 1986, Volume: 18, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Avoidance Learning; Food Preferences; Male; Naltrexone; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Saccharin; Taste	1986
Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity. Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:10 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Humans; Kinetics; Liver; Mice; Monoamine Oxidase; Neurotoxins; Pargyline; Pyridines; Rats	1987
Astrocytes convert the parkinsonism inducing neurotoxin, MPTP, to its active metabolite, MPP+. Neuroscience letters, 1987, Apr-10, Volume: 75, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Mice; Pargyline; Pyridines; Pyridinium Compounds	1987
Role of 1-methyl-4-phenylpyridinium ion formation and accumulation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity to isolated hepatocytes. Chemico-biological interactions, 1987, Volume: 62, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine Triphosphate; Animals; Biotransformation; Dose-Response Relationship, Drug; Ions; Liver; Male; Pargyline; Pyridines; Pyridinium Compounds; Rats	1987
Chronic alterations in jejunal myoelectric activity in rats due to MPTP. The American journal of physiology, 1987, Volume: 253, Issue:6 Pt 1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Catecholamines; Caudate Nucleus; Electromyography; Electrophysiology; Gastrointestinal Motility; Ileum; Jejunum; Pargyline; Parkinson Disease; Pyridines; Rats; Substantia Nigra	1987
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on dopamine synthesis and release in the rabbit retina in vitro. Neuropharmacology, 1987, Volume: 26, Issue:11 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine; Female; In Vitro Techniques; Male; Monoamine Oxidase; Nerve Tissue Proteins; Pargyline; Pyridines; Rabbits; Retina	1987
Selective accumulation of MPP+ in the substantia nigra: a key to neurotoxicity? Life sciences, 1985, Jan-21, Volume: 36, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain Chemistry; Male; Pargyline; Pyridines; Pyridinium Compounds; Saimiri; Substantia Nigra; Tissue Distribution	1985
Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life sciences, 1985, Jan-21, Volume: 36, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Mitochondria; Monoamine Oxidase; Pargyline; Pyridines; Rats	1985
Neurochemical and functional consequences following 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) and methamphetamine. Life sciences, 1985, Jan-21, Volume: 36, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Corpus Striatum; Dopamine; Drug Interactions; Female; Male; Methamphetamine; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Serotonin; Species Specificity	1985
Inhibition of types A and B monoamine oxidase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dextroamphetamine; Dogs; Dopamine; Homovanillic Acid; In Vitro Techniques; Kinetics; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Pyridines; Rats; Rats, Inbred Strains	1985
New amphibian models for the study of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life sciences, 1985, Mar-18, Volume: 36, Issue:11 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain Chemistry; Catechol O-Methyltransferase Inhibitors; Catecholamines; Disease Models, Animal; Melanophores; Motor Activity; Movement; Pargyline; Parkinson Disease, Secondary; Pyridines; Pyridinium Compounds; Pyrogallol; Ranidae; Reflex; Salamandridae; Skin Pigmentation	1985
Localization in rat brain of binding sites for parkinsonian toxin MPTP: similarities with [3H]pargyline binding to monoamine oxidase. Brain research, 1985, Mar-25, Volume: 330, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Binding Sites; Brain; In Vitro Techniques; Isoenzymes; Kinetics; Locus Coeruleus; Male; Monoamine Oxidase; Neurosecretory Systems; Pargyline; Pyridines; Rats	1985
Similar distribution of monoamine oxidase (MAO) and parkinsonian toxin (MPTP) binding sites in human brain. Neurology, 1985, Volume: 35, Issue:10 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Autoradiography; Binding Sites; Brain; Humans; Male; Middle Aged; Monoamine Oxidase; Pargyline; Parkinson Disease; Pyridines	1985
Comparative behavioral, biochemical and pigmentary effects of MPTP, MPP+ and paraquat in Rana pipiens. Life sciences, 1985, Oct-21, Volume: 37, Issue:16 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adrenal Medulla; Animals; Behavior, Animal; Brain Chemistry; Dopamine; Drug Interactions; Epinephrine; Melanophores; Motor Activity; Norepinephrine; Paraquat; Pargyline; Parkinson Disease, Secondary; Pigmentation; Posture; Pyridines; Pyridinium Compounds; Rana pipiens; Reflex	1985
Studies on the mechanism of action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life sciences, 1985, Jan-21, Volume: 36, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Culture Techniques; Female; Kinetics; Monoamine Oxidase; Pargyline; Pregnancy; Pyridines; Rats; Selegiline; Substantia Nigra	1985
Behavioural effects in the rat after acute unilateral intranigral infusions of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain research, 1985, Jul-29, Volume: 339, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dextroamphetamine; Drug Interactions; Female; Haloperidol; Hydroxydopamines; Motor Activity; Oxidopamine; Pargyline; Picrotoxin; Pyridines; Rats; Rotation; Substantia Nigra	1985
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: correspondence of its binding sites to monoamine oxidase in rat brain, and inhibition of dopamine oxidative deamination in vivo and in vitro. Journal of neurochemistry, 1985, Volume: 45, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Binding Sites; Clorgyline; Corpus Striatum; Deamination; Dopamine; In Vitro Techniques; Male; Monoamine Oxidase; Oxidation-Reduction; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline; Subcellular Fractions	1985
Inhibition of tyrosine hydroxylation in rat striatal tissue slices by 1-methyl-4-phenylpyridinium ion. Neuroscience letters, 1985, Jun-24, Volume: 57, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dihydroxyphenylalanine; Hydroxylation; In Vitro Techniques; Male; Monoamine Oxidase; Pargyline; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Tyrosine	1985
Prevention of MPTP-induced neurotoxicity by AGN-1133 and AGN-1135, selective inhibitors of monoamine oxidase-B. European journal of pharmacology, 1985, Oct-22, Volume: 116, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzylamines; Brain; Dopamine; Indans; Indenes; Male; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Pargyline; Pyridines; Selegiline; Tryptamines	1985
Pargyline prevents MPTP-induced parkinsonism in primates. Science (New York, N.Y.), 1984, Sep-28, Volume: 225, Issue:4669 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain Chemistry; Male; Neurons; Pargyline; Parkinson Disease, Secondary; Pyridines; Pyridinium Compounds; Saimiri; Substantia Nigra	1984
High-affinity binding sites for [3H]MPTP may correspond to monamine oxidase. European journal of pharmacology, 1984, Jul-13, Volume: 102, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Binding Sites; Brain; Monoamine Oxidase; Pargyline; Parkinson Disease; Pyridines; Rats	1984
Inhibition of [3H] MPTP binding to rat brain by pargyline. Biochemical pharmacology, 1984, Dec-15, Volume: 33, Issue:24 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; In Vitro Techniques; Male; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Tritium	1984
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochemical and biophysical research communications, 1984, Apr-30, Volume: 120, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Brain; Kinetics; Male; Mitochondria; Monoamine Oxidase; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline	1984
Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys. European journal of pharmacology, 1984, Oct-30, Volume: 106, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Caudate Nucleus; Dopamine; Female; Homovanillic Acid; Macaca fascicularis; Pargyline; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline	1984
Inhibition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolic activity of porcine FAD-containing monooxygenase by selective monoamine oxidase-B inhibitors. FEBS letters, 1995, Jan-23, Volume: 358, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Female; Microsomes, Liver; Monoamine Oxidase Inhibitors; Oxygenases; Pargyline; Selegiline; Substrate Specificity; Swine	1995
Inhibition of gastrointestinal motility by MPTP via adrenergic and dopaminergic mechanisms. Digestive diseases and sciences, 1994, Volume: 39, Issue:11 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine; Gastrointestinal Motility; Haloperidol; Isoproterenol; Male; Mice; Mice, Inbred BALB C; Pargyline; Phentolamine; Propranolol; Receptors, Adrenergic	1994
1-Methyl-4-phenylpyridinium (MPP+) binds with high affinity to a beta-carboline binding site located on monoamine oxidase type A in rat brain. Neuroscience letters, 1993, Nov-12, Volume: 162, Issue:1-2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding, Competitive; Brain; Carbolines; Cerebral Cortex; Harmine; Male; Monoamine Oxidase; Pargyline; Pyridinium Compounds; Rats; Rats, Wistar	1993
Neurochemical and neuroprotective effects of some aliphatic propargylamines: new selective nonamphetamine-like monoamine oxidase B inhibitors. Journal of neurochemistry, 1994, Volume: 62, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amines; Amphetamines; Animals; Benzylamines; Brain; Catecholamines; Caudate Nucleus; Hypothalamus; Male; Mice; Mice, Inbred Strains; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotoxins; Pargyline; Serotonin	1994
An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines. Biochemical pharmacology, 1993, Feb-24, Volume: 45, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Catalase; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lipid Peroxides; MPTP Poisoning; Neurons; Pargyline; Rats; Reactive Oxygen Species; Selegiline; Superoxide Dismutase; Tumor Cells, Cultured	1993
MPTP neurotoxicity to cerebellar Purkinje cells in mice. Neuroscience letters, 1993, Feb-05, Volume: 150, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benztropine; Dose-Response Relationship, Drug; Male; Mazindol; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; MPTP Poisoning; Neurotoxins; Pargyline; Purkinje Cells; Selegiline	1993
Pargyline pretreatment prevents immunological changes induced by MPTP in mice. Immunopharmacology, 1996, Volume: 35, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antibody Formation; CD4-Positive T-Lymphocytes; Corpus Striatum; Dopamine Antagonists; Drug Administration Schedule; Immunity; Lymphocyte Subsets; Male; Mice; Mice, Inbred C57BL; Pargyline; Phagocytosis; Substantia Nigra; Tumor Necrosis Factor-alpha	1996
PET studies of functional compensation in a primate model of Parkinson's disease. Neuroreport, 1997, Aug-18, Volume: 8, Issue:12 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Progression; Dopamine Agents; Fluorine Radioisotopes; Macaca mulatta; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Neurotoxins; Pargyline; Parkinson Disease, Secondary; Tomography, Emission-Computed; Tyrosine	1997
Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Immunopharmacology, 1998, Volume: 39, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Disease Models, Animal; Dopamine; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron; MPTP Poisoning; Pargyline; Parkinson Disease, Secondary; Substantia Nigra	1998
Differential time courses of exogenous 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine and its metabolite MPP+ in the rat striatum and nucleus accumbens measured using in vivo voltammetry. Brain research, 1998, Nov-23, Volume: 812, Issue:1-2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Electrochemistry; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nucleus Accumbens; Pargyline; Rats; Rats, Wistar	1998
Protective effect of riluzole on MPTP-induced depletion of dopamine and its metabolite content in mice. Metabolic brain disease, 2000, Volume: 15, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Pargyline; Receptors, N-Methyl-D-Aspartate; Riluzole; Sodium Channels; Time Factors	2000
Pharmacological properties of the MPTP analog trans-1-methyl-4-[4-dimethylaminophenylethenyl]-1,2,3,6-tetrahydropyridine and its pyridinium metabolite in mouse brain synaptosomes: a potential visual marker for substrates of MPTP-induced neurotoxicity. Progress in neuro-psychopharmacology & biological psychiatry, 2001, Volume: 25, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Monoamine Oxidase Inhibitors; Neurotoxins; Pargyline; Serotonin; Synaptosomes	2001
Therapeutic effect of neuronal nitric oxide synthase inhibitor (7-nitroindazole) against MPTP neurotoxicity in mice. Metabolic brain disease, 2002, Volume: 17, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Arginine; Brain Chemistry; Dopamine; Dopamine Agents; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Immunohistochemistry; Indazoles; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Neostriatum; Neurotoxicity Syndromes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pargyline; Tyrosine 3-Monooxygenase	2002
Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism. Experimental neurology, 2003, Volume: 179, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Brain; Cats; Choline; Corpus Striatum; Creatine; Disease Models, Animal; Disease Progression; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neurologic Examination; Pargyline; Parkinsonian Disorders; Predictive Value of Tests; Protons; Tyrosine 3-Monooxygenase	2003