Page last updated: 2024-09-03

parecoxib and valdecoxib

parecoxib has been researched along with valdecoxib in 46 studies

Compound Research Comparison

Studies
(parecoxib)
Trials
(parecoxib)
Recent Studies (post-2010)
(parecoxib)
Studies
(valdecoxib)
Trials
(valdecoxib)
Recent Studies (post-2010) (valdecoxib)
4361862293757186

Protein Interaction Comparison

ProteinTaxonomyparecoxib (IC50)valdecoxib (IC50)
Cytochrome c oxidase subunit 2Homo sapiens (human)1.1
Carbonic anhydrase 1Homo sapiens (human)0.1915
Carbonic anhydrase 2Homo sapiens (human)1.0086
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.927
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.927
Prostaglandin G/H synthase 2Homo sapiens (human)0.0631
Carbonic anhydrase 9Homo sapiens (human)0.027
Carbonic anhydrase 4Bos taurus (cattle)0.2658

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's32 (69.57)29.6817
2010's13 (28.26)24.3611
2020's1 (2.17)2.80

Authors

AuthorsStudies
Bechmann, N; Kniess, T; Köckerling, M; Pietzsch, J; Roscales, S; Weiss, DH1
Jain, KK1
Crosby-Sessoms, SL; Hubbard, RC; Karim, A; Kuss, ME; Laurent, A; Qian, J; Slater, ME1
Hardy, KJ; McMurray, RW1
Frölich, JC; Stichtenoth, DO1
Alston, RP; Duke, PC; Feneck, RO; Hsu, PH; Hubbard, RC; Mangano, DT; Nussmeier, NA; Ott, E; Saidman, LJ; Snabes, MC1
Daniels, S; Desjardins, PJ; Hubbard, RC; Mehlisch, DR1
Cryer, B1
Burian, M; Geisslinger, G1
Cheung, RY; Cippolle, M; Fort, JG; Gan, TJ; Joshi, GP; Minkowitz, H; Schuller, R; Viscusi, ER1
Møiniche, S; Rømsing, J1
Chen, C; Cheung, RY; Dodge, W; Fort, JG; Gan, TJ; Joshi, GP; Viscusi, E1
Chen, C; Cleeland, CS; Hanna, DB; Jensen, MP; Mendoza, T1
Benoit, V; de Leval, X; Dogné, JM; Frederich, M; Julémont, F; Pirotte, B1
Chen, C; Cheung, RY; Gan, TJ; Hanna, DB; Joshi, GP; Zhao, SZ1
FitzGerald, GA; Furberg, CD; Psaty, BM1
Boyce, SW; Brown, MT; Hoeft, A; Langford, RM; Nussmeier, NA; Parlow, JL; Verburg, KM; Whelton, AA1
Furberg, CD; Psaty, BM1
Drazen, JM1
Cheung, R; Jensen, MP; Martin, SA1
Aziz, Q; Delaney, C; Hobson, AR; Thompson, DG; Willert, RP; Woolf, CJ1
Meechan, J1
Aldington, S; Beasley, R; Shirtcliffe, P; Weatherall, M1
Boye, ME; Brown, MT; Joshi, GP; Langford, RM; Nussmeier, NA; Singla, NK; Verburg, KM; Whelton, AA1
Bucher, M; Hobbhahn, J; Kees, FK; Lunz, D; Messmann, B; Rath, S; Schlitt, HJ; Zelenka, M1
Bittner, R; Junginger, W; Kraft, B; Leroy, S; Schweizer, M1
Al-Sukhun, J; Koivusalo, A; Lindqvist, C; Törnwall, J1
Deray, G; Montalescot, G; Sibilia, J1
Engelman, E; Salengros, JC1
Bello, A; Cheung, R; Johnston, A; Langford, RM; Mehta, V1
Benson, SE; Charteris, DG; Khan, I; Langford, RM; Newsom, R; Ratclliffe, S; Schlottmann, PG; Van Raders, P1
Camu, F; Cheung, R; Joshi, GP; Pan, S; Schug, SA1
Chen, C; Chen, WH; Gan, TJ; Joshi, GP; Langford, RM; Mattera, MS; Revicki, DA; Zlateva, G1
Bankstahl, M; Löscher, W; Polascheck, N1
Elliott, WJ1
Fuskevåg, OM; Reikerås, O; Shegarfi, H; Utvåg, SE1
Becker, A; Höllt, V; Schröder, H1
Del Carlo, S; Giorgi, M; Macchia, M; Manera, C; Saba, A; Saccomanni, G1
Del Carlo, S; Giorgi, M; Lavy, E; Manera, C; Saccomanni, G1
Ilett, KF; Muchatuta, NA; O'Halloran, SJ; Paech, MJ; Salman, S1
Davies, K; Hullett, B; Ilett, KF; O'Halloran, SJ; Peirce, D; Salman, S1
Darabi, A; Eberstål, S; Fritzell, S; Sandén, E; Siesjö, P; Visse, E1
Briganti, A; Giorgi, M; Kim, TW; Re, G; Vercelli, C1
Fang, M; He, Z; Li, P; Liu, M; Liu, X; Sun, B; Sun, J; Sun, M; Sun, Y; Wang, Y; Yu, Q; Zhang, P; Zhu, M1
Cheng, C; Jia, Y; Jin, X; Liu, Y; Wang, G; Yao, L; Zhang, J; Zhou, F1
Li, SB; Li, SL; Li, ZH; Qiu, XJ; Zhu, CY; Zhu, YL1

Reviews

11 review(s) available for parecoxib and valdecoxib

ArticleYear
Evaluation of intravenous parecoxib for the relief of acute post-surgical pain.
    Expert opinion on investigational drugs, 2000, Volume: 9, Issue:11

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain, Postoperative; Prodrugs; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2000
Cox-2 inhibitors: today and tomorrow.
    The American journal of the medical sciences, 2002, Volume: 323, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Etoricoxib; Humans; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Research; Sulfonamides; Sulfones

2002
The second generation of COX-2 inhibitors: what advantages do the newest offer?
    Drugs, 2003, Volume: 63, Issue:1

    Topics: Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Etoricoxib; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Organic Chemicals; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfonamides; Sulfones

2003
The role of cyclooxygenase selective inhibitors in the gastrointestinal tract.
    Current gastroenterology reports, 2003, Volume: 5, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Etoricoxib; Humans; Isoxazoles; Pyridines; Sulfonamides; Sulfones; Ulcer

2003
[Clinical pharmacology of the selective COX-2 inhibitors].
    Der Orthopade, 2003, Volume: 32, Issue:12

    Topics: Acute Disease; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Pain; Pain, Postoperative; Placebos; Pyrazoles; Sulfonamides; Sulfones

2003
A systematic review of COX-2 inhibitors compared with traditional NSAIDs, or different COX-2 inhibitors for post-operative pain.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Lactones; Pain Measurement; Pain, Postoperative; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Sulfones; Treatment Outcome

2004
First and second generations of COX-2 selective inhibitors.
    Mini reviews in medicinal chemistry, 2004, Volume: 4, Issue:6

    Topics: Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etoricoxib; Gastrointestinal Diseases; Humans; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Sulfonamides; Sulfones

2004
Increased risk of cardiovascular events with parecoxib/valdecoxib: a systematic review and meta-analysis.
    The New Zealand medical journal, 2005, Nov-25, Volume: 118, Issue:1226

    Topics: Cardiac Surgical Procedures; Cardiovascular Diseases; Cerebrovascular Disorders; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Myocardial Infarction; Odds Ratio; Outcome and Process Assessment, Health Care; Pain, Postoperative; Risk Factors; Sulfonamides; Survival Analysis

2005
[What do we know about the cardiovascular toxicity of the NSAIDs?].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:9 Spec No

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Case-Control Studies; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Follow-Up Studies; Humans; Isoxazoles; Lactones; Meta-Analysis as Topic; Middle Aged; Naproxen; Pyrazoles; Randomized Controlled Trials as Topic; Risk Factors; Sulfonamides; Sulfones; Thrombosis; Time Factors

2006
Cardiovascular safety of the cyclooxygenase-2 selective inhibitors parecoxib and valdecoxib in the postoperative setting: an analysis of integrated data.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Cyclooxygenase 2 Inhibitors; Female; Humans; Incidence; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Postoperative Care; Risk Assessment; Risk Factors; Sulfonamides; Thromboembolism; Young Adult

2009
Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality?
    Current hypertension reports, 2010, Volume: 12, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Humans; Hypertension; Isoxazoles; Lactones; Pyrazoles; Pyridines; Risk; Risk Factors; Sulfonamides; Sulfones

2010

Trials

19 trial(s) available for parecoxib and valdecoxib

ArticleYear
A pharmacokinetic study of intramuscular (i.m.) parecoxib sodium in normal subjects.
    Journal of clinical pharmacology, 2001, Volume: 41, Issue:10

    Topics: Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cyclooxygenase Inhibitors; Double-Blind Method; Humans; Injections, Intramuscular; Isoxazoles; Male; Middle Aged; Sulfonamides

2001
Efficacy and safety of the cyclooxygenase 2 inhibitors parecoxib and valdecoxib in patients undergoing coronary artery bypass surgery.
    The Journal of thoracic and cardiovascular surgery, 2003, Volume: 125, Issue:6

    Topics: Administration, Oral; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Coronary Artery Bypass; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Morphine; Pain Measurement; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Safety; Sulfonamides

2003
Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2003, Volume: 61, Issue:9

    Topics: Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Molar, Third; Pain Measurement; Pain, Postoperative; Prodrugs; Prostaglandin-Endoperoxide Synthases; Safety; Sulfonamides; Survival Analysis; Time Factors; Tooth Extraction

2003
Effective treatment of laparoscopic cholecystectomy pain with intravenous followed by oral COX-2 specific inhibitor.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:2

    Topics: Administration, Oral; Adult; Cholecystectomy, Laparoscopic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2004
Preoperative parenteral parecoxib and follow-up oral valdecoxib reduce length of stay and improve quality of patient recovery after laparoscopic cholecystectomy surgery.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Administration, Oral; Analysis of Variance; Cholecystectomy, Laparoscopic; Double-Blind Method; Female; Humans; Isoxazoles; Length of Stay; Male; Middle Aged; Multivariate Analysis; Postoperative Care; Preoperative Care; Sulfonamides

2004
The analgesic effects that underlie patient satisfaction with treatment.
    Pain, 2004, Volume: 110, Issue:1-2

    Topics: Adult; Analgesics; Cholecystectomy, Laparoscopic; Double-Blind Method; Drug Administration Routes; Drug Administration Schedule; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Outcome Assessment, Health Care; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Postoperative Care; Preoperative Care; Prospective Studies; Retrospective Studies; Sex Factors; Sulfonamides; Time Factors

2004
Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:9

    Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Cholecystectomy, Laparoscopic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Hydrocodone; Injections, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2004
Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery.
    The New England journal of medicine, 2005, Mar-17, Volume: 352, Issue:11

    Topics: Administration, Oral; Adult; Aged; Cardiovascular Diseases; Coronary Artery Bypass; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Infusions, Intravenous; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Sulfonamides

2005
The meaning of pain relief in a clinical trial.
    The journal of pain, 2005, Volume: 6, Issue:6

    Topics: Administration, Oral; Adult; Analgesia; Analgesics; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Isoxazoles; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Sulfonamides; Treatment Outcome

2005
Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity.
    European journal of pain (London, England), 2006, Volume: 10, Issue:6

    Topics: Adult; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Administration Schedule; Electric Stimulation; Esophagus; Female; Humans; Hydrochloric Acid; Isoxazoles; Male; Middle Aged; Pain Threshold; Sulfonamides; Viscera

2006
COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003.
    The British journal of oral & maxillofacial surgery, 2006, Volume: 44, Issue:2

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Ibuprofen; Injections, Intravenous; Isoxazoles; Lactones; Pain, Postoperative; Preanesthetic Medication; Prodrugs; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction

2006
Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery.
    Anesthesiology, 2006, Volume: 104, Issue:3

    Topics: Adult; Aged; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain, Postoperative; Sulfonamides

2006
Prostaglandin I2 release following mesenteric traction during abdominal surgery is mediated by cyclooxygenase-1.
    European journal of pharmacology, 2006, May-01, Volume: 536, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Abdomen; Blood Pressure; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Epoprostenol; Female; Flushing; Heart Rate; Humans; Hypotension; Intraoperative Complications; Isoxazoles; Laparoscopy; Male; Middle Aged; Oxygen; Prospective Studies; Sulfonamides; Surgical Procedures, Operative; Tachycardia; Time Factors; Treatment Outcome

2006
[Analgesia in colon surgery. Can the use of NSAIDs reduce the opioid consumption following conventional and laparoscopic interventions?].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2006, Volume: 77, Issue:10

    Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Isoxazoles; Laparoscopy; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Pirinitramide; Prospective Studies; Rectal Diseases; Sulfonamides

2006
Intravenous parecoxib rapidly leads to COX-2 inhibitory concentration of valdecoxib in the central nervous system.
    Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:3

    Topics: Aged; Central Nervous System; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Humans; Inhibitory Concentration 50; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Sulfonamides; Time Factors

2008
A randomized comparison of parecoxib/valdecoxib and placebo for the prevention of cystoid macular edema after scleral buckling surgery.
    Retina (Philadelphia, Pa.), 2009, Volume: 29, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Contrast Sensitivity; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Fluorescein Angiography; Humans; Incidence; Isoxazoles; Macular Edema; Male; Middle Aged; Prospective Studies; Retinal Detachment; Scleral Buckling; Subretinal Fluid; Sulfonamides; Tomography, Optical Coherence; Visual Acuity; Young Adult

2009
Reduction in opioid-related adverse events and improvement in function with parecoxib followed by valdecoxib treatment after non-cardiac surgery: a randomized, double-blind, placebo-controlled, parallel-group trial.
    Clinical drug investigation, 2009, Volume: 29, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Attitude of Health Personnel; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Elective Surgical Procedures; Female; Humans; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Patient Satisfaction; Placebos; Psychometrics; Sulfonamides

2009
Pharmacokinetics of intravenous and intramuscular parecoxib in healthy Beagles.
    Veterinary journal (London, England : 1997), 2012, Volume: 193, Issue:1

    Topics: Acute Pain; Analgesia; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Dogs; Half-Life; Injections, Intramuscular; Injections, Intravenous; Isoxazoles; Male; Prodrugs; Sulfonamides

2012
The pharmacokinetics and in vitro/ex vivo cyclooxygenase selectivity of parecoxib and its active metabolite valdecoxib in cats.
    Veterinary journal (London, England : 1997), 2014, Volume: 202, Issue:1

    Topics: Animals; Area Under Curve; Cats; Cyclooxygenase Inhibitors; Isoxazoles; Male; Sulfonamides

2014

Other Studies

16 other study(ies) available for parecoxib and valdecoxib

ArticleYear
Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.
    MedChemComm, 2018, Mar-01, Volume: 9, Issue:3

    Topics:

2018
Parecoxib, valdecoxib, and cardiovascular risk.
    Circulation, 2005, Jan-25, Volume: 111, Issue:3

    Topics: Cardiovascular Diseases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Membrane Proteins; Meta-Analysis as Topic; Prodrugs; Product Surveillance, Postmarketing; Prostaglandin-Endoperoxide Synthases; Randomized Controlled Trials as Topic; Risk Assessment; Sulfonamides

2005
COX-2 inhibitors--lessons in drug safety.
    The New England journal of medicine, 2005, Mar-17, Volume: 352, Issue:11

    Topics: Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Approval; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Publishing; Pyrazoles; Randomized Controlled Trials as Topic; Research Design; Sulfonamides; Sulfones; United States; United States Food and Drug Administration

2005
COX-2 inhibitors--a lesson in unexpected problems.
    The New England journal of medicine, 2005, Mar-17, Volume: 352, Issue:11

    Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Approval; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones

2005
COX-2 inhibitors and early failure of free vascular flaps.
    The New England journal of medicine, 2006, Aug-03, Volume: 355, Issue:5

    Topics: Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Pain, Postoperative; Sulfonamides; Surgical Flaps; Treatment Failure

2006
Safety of parecoxib and valdecoxib after noncardiac surgery: lack of demonstration.
    Anesthesiology, 2007, Volume: 106, Issue:1

    Topics: Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Pain, Postoperative; Safety; Sulfonamides

2007
The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy.
    Experimental neurology, 2010, Volume: 224, Issue:1

    Topics: Analysis of Variance; Animals; Cell Count; Cell Death; Cerebral Cortex; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Electrodes, Implanted; Electroencephalography; Enzyme-Linked Immunosorbent Assay; Epilepsy, Temporal Lobe; Female; Isoxazoles; Motor Activity; Neurons; Neuroprotective Agents; Pilocarpine; Random Allocation; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Statistics, Nonparametric; Sulfonamides; Video Recording

2010
Short-term treatment with COX-2 inhibitors does not impair fracture healing.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2010, Volume: 23, Issue:5

    Topics: Animals; Bone Density; Cyclooxygenase 2 Inhibitors; Diclofenac; Fracture Healing; Isoxazoles; Male; Rats; Rats, Wistar; Sulfonamides

2010
Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue.
    Neurochemistry international, 2011, Volume: 58, Issue:1

    Topics: Amino Acids; Animals; Binding, Competitive; Brain Chemistry; Cyclic AMP; Cyclohexanols; Cyclooxygenase 2 Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Isoxazoles; Male; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sulfonamides; Transfection

2011
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology.
    Analytical and bioanalytical chemistry, 2011, Volume: 401, Issue:5

    Topics: Animals; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Dogs; Isoxazoles; Sensitivity and Specificity; Spectrometry, Fluorescence; Sulfonamides

2011
Transfer of parecoxib and its primary active metabolite valdecoxib via transitional breastmilk following intravenous parecoxib use after cesarean delivery: a comparison of naive pooled data analysis and nonlinear mixed-effects modeling.
    Anesthesia and analgesia, 2012, Volume: 114, Issue:4

    Topics: Adult; Biological Transport; Cesarean Section; Cyclooxygenase 2 Inhibitors; Female; Humans; Infant, Newborn; Injections, Intravenous; Isoxazoles; Male; Milk, Human; Models, Biological; Nonlinear Dynamics; Sulfonamides

2012
Development of a population pharmacokinetic model for parecoxib and its active metabolite valdecoxib after parenteral parecoxib administration in children.
    Anesthesiology, 2012, Volume: 116, Issue:5

    Topics: Adult; Age Factors; Algorithms; Biotransformation; Child; Child, Preschool; Computer Simulation; Cyclooxygenase 2 Inhibitors; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infant; Infusions, Parenteral; Isoxazoles; Male; Models, Statistical; Nonlinear Dynamics; Population; Prospective Studies; Reproducibility of Results; Sulfonamides

2012
Intratumoral COX-2 inhibition enhances GM-CSF immunotherapy against established mouse GL261 brain tumors.
    International journal of cancer, 2014, Jun-01, Volume: 134, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drug Synergism; Female; Flow Cytometry; Glioma; Granulocyte-Macrophage Colony-Stimulating Factor; Immunoenzyme Techniques; Immunotherapy; Intramolecular Oxidoreductases; Isoxazoles; Mice; Mice, Inbred C57BL; Prostaglandin-E Synthases; Sulfonamides; Tumor Cells, Cultured

2014
Simultaneous determination of parecoxib sodium and its active metabolite valdecoxib in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study after intravenous and intramuscular administration.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Jun-01, Volume: 1022

    Topics: Administration, Intravenous; Animals; Chromatography, High Pressure Liquid; Injections, Intramuscular; Isoxazoles; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Sulfonamides; Tandem Mass Spectrometry

2016
Simultaneous determination of parecoxib and its main metabolites valdecoxib and hydroxylated valdecoxib in mouse plasma with a sensitive LC-MS/MS method to elucidate the decreased drug metabolism of tumor bearing mice.
    Journal of pharmaceutical and biomedical analysis, 2018, Sep-05, Volume: 158

    Topics: Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme System; Drug Monitoring; Female; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Neoplasms; Oxazoles; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Tandem Mass Spectrometry; Xenograft Model Antitumor Assays

2018
Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study.
    Drug design, development and therapy, 2020, Volume: 14

    Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Injections, Intramuscular; Isoxazoles; Molecular Structure; Sulfonamides; Tandem Mass Spectrometry

2020