Page last updated: 2024-09-03

parecoxib and rofecoxib

parecoxib has been researched along with rofecoxib in 15 studies

Compound Research Comparison

Studies
(parecoxib)
Trials
(parecoxib)
Recent Studies (post-2010)
(parecoxib)
Studies
(rofecoxib)
Trials
(rofecoxib)
Recent Studies (post-2010) (rofecoxib)
4361862291,914307163

Protein Interaction Comparison

ProteinTaxonomyparecoxib (IC50)rofecoxib (IC50)
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.43
Cytochrome c oxidase subunit 2Homo sapiens (human)1.51
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)0.5
Calpain-2 catalytic subunitHomo sapiens (human)0.02
Prostaglandin G/H synthase 1Homo sapiens (human)1.8
Prostaglandin G/H synthase 2Homo sapiens (human)0.3602
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.76
Prostaglandin G/H synthase 2Ovis aries (sheep)0.486
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.036
Sodium-dependent serotonin transporterMacaca mulatta (Rhesus monkey)0.5

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (86.67)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hardy, KJ; McMurray, RW1
Boehncke, WH; Gibbs, BF1
Burian, M; Geisslinger, G1
Møiniche, S; Rømsing, J1
Benoit, V; de Leval, X; Dogné, JM; Frederich, M; Julémont, F; Pirotte, B1
Furberg, CD; Psaty, BM1
Drazen, JM1
Meechan, J1
Babul, N; Lipman, AG; Sloan, P1
Nylander, O; Pihl, L1
Deray, G; Montalescot, G; Sibilia, J1
Arguelles, J; Cobo, J; Costales, M; de Carlos, F; Garcia, MA; Perillan, C; Vijande, M1
Cacheux, W; Chaussade, S; de Reyniès, A; Hamzaoui, N; Lamarque, D; Perret, C; Romagnolo, B; Terris, B; Zagani, R1
Elliott, WJ1
Balbontín-Ayala, F; Cañigral, A; Carlos, Fd; Cobo, T; Fernández-González, FJ; Fernández-Vázquez, JP; Gonzalo-Orden, JM; Sánchez-Lasheras, F; Vega, JA1

Reviews

7 review(s) available for parecoxib and rofecoxib

ArticleYear
Cox-2 inhibitors: today and tomorrow.
    The American journal of the medical sciences, 2002, Volume: 323, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Etoricoxib; Humans; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Research; Sulfonamides; Sulfones

2002
[Clinical pharmacology of the selective COX-2 inhibitors].
    Der Orthopade, 2003, Volume: 32, Issue:12

    Topics: Acute Disease; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Pain; Pain, Postoperative; Placebos; Pyrazoles; Sulfonamides; Sulfones

2003
A systematic review of COX-2 inhibitors compared with traditional NSAIDs, or different COX-2 inhibitors for post-operative pain.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Lactones; Pain Measurement; Pain, Postoperative; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Sulfones; Treatment Outcome

2004
First and second generations of COX-2 selective inhibitors.
    Mini reviews in medicinal chemistry, 2004, Volume: 4, Issue:6

    Topics: Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etoricoxib; Gastrointestinal Diseases; Humans; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Sulfonamides; Sulfones

2004
[What do we know about the cardiovascular toxicity of the NSAIDs?].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:9 Spec No

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Case-Control Studies; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Follow-Up Studies; Humans; Isoxazoles; Lactones; Meta-Analysis as Topic; Middle Aged; Naproxen; Pyrazoles; Randomized Controlled Trials as Topic; Risk Factors; Sulfonamides; Sulfones; Thrombosis; Time Factors

2006
Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality?
    Current hypertension reports, 2010, Volume: 12, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Humans; Hypertension; Isoxazoles; Lactones; Pyrazoles; Pyridines; Risk; Risk Factors; Sulfonamides; Sulfones

2010
Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review.
    Dental press journal of orthodontics, 2015, Volume: 20, Issue:5

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Bone Remodeling; Celecoxib; Clodronic Acid; Diclofenac; Diphosphonates; Humans; Imidazoles; Interferon-gamma; Isoxazoles; Lactones; Mice; Orthodontic Anchorage Procedures; Osteoclasts; Osteoprotegerin; Pamidronate; Rats; Resveratrol; Stilbenes; Sulfones; Tooth Mobility; Tooth Movement Techniques; Zoledronic Acid

2015

Trials

1 trial(s) available for parecoxib and rofecoxib

ArticleYear
COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003.
    The British journal of oral & maxillofacial surgery, 2006, Volume: 44, Issue:2

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Ibuprofen; Injections, Intravenous; Isoxazoles; Lactones; Pain, Postoperative; Preanesthetic Medication; Prodrugs; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction

2006

Other Studies

7 other study(ies) available for parecoxib and rofecoxib

ArticleYear
Effects of rofecoxib, celecoxib, and parecoxib on anti-IgE-induced histamine release from human skin mast cells and basophils.
    Allergy, 2003, Volume: 58, Issue:10

    Topics: Antibodies, Anti-Idiotypic; Basophils; Celecoxib; Cyclooxygenase Inhibitors; Histamine Release; Humans; Isoxazoles; Lactones; Mast Cells; Pyrazoles; Skin; Sulfonamides; Sulfones

2003
COX-2 inhibitors--lessons in drug safety.
    The New England journal of medicine, 2005, Mar-17, Volume: 352, Issue:11

    Topics: Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Approval; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Publishing; Pyrazoles; Randomized Controlled Trials as Topic; Research Design; Sulfonamides; Sulfones; United States; United States Food and Drug Administration

2005
COX-2 inhibitors--a lesson in unexpected problems.
    The New England journal of medicine, 2005, Mar-17, Volume: 352, Issue:11

    Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Approval; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones

2005
Postsurgical safety of opioid-sparing cyclooxygenase-2 inhibitors.
    Anesthesiology, 2006, Volume: 104, Issue:2

    Topics: Analgesics, Opioid; Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Lactones; Pain, Postoperative; Sulfones

2006
Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery.
    Acta physiologica (Oxford, England), 2006, Volume: 186, Issue:4

    Topics: Animals; Bicarbonates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Duodenum; Gastrointestinal Motility; Intestinal Absorption; Intestinal Mucosa; Isoxazoles; Lactones; Laparotomy; Male; Osmolar Concentration; Perfusion; Pyrazoles; Rats; Rats, Inbred Lew; Sodium Chloride; Sulfones

2006
Orthodontic tooth movement after different coxib therapies.
    European journal of orthodontics, 2007, Volume: 29, Issue:6

    Topics: Alveolar Process; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cephalometry; Cyclooxygenase 2 Inhibitors; Gingiva; Isoxazoles; Lactones; Male; Molar; Orthodontic Wires; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Sulfones; Time Factors; Tooth Movement Techniques

2007
Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers.
    Gastroenterology, 2009, Volume: 137, Issue:4

    Topics: Adenomatous Polyposis Coli; Animals; Antineoplastic Agents; beta Catenin; Cell Line, Tumor; Cell Survival; Colonic Polyps; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; DNA-Binding Proteins; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, APC; Humans; Isoxazoles; Lactones; Mice; Mice, Mutant Strains; Nuclear Receptor Subfamily 4, Group A, Member 2; Oligonucleotide Array Sequence Analysis; Osteopontin; Promoter Regions, Genetic; RNA Interference; Signal Transduction; Sulfones; Time Factors; Transcription Factors; Transfection; Wnt Proteins

2009