parecoxib has been researched along with rofecoxib in 15 studies
| Studies (parecoxib) | Trials (parecoxib) | Recent Studies (post-2010) (parecoxib) | Studies (rofecoxib) | Trials (rofecoxib) | Recent Studies (post-2010) (rofecoxib) |
|---|---|---|---|---|---|
| 436 | 186 | 229 | 1,914 | 307 | 163 |
| Protein | Taxonomy | parecoxib (IC50) | rofecoxib (IC50) |
|---|---|---|---|
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | 0.43 | |
| Cytochrome c oxidase subunit 2 | Homo sapiens (human) | 1.51 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 0.5 | |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | 0.5 | |
| Calpain-2 catalytic subunit | Homo sapiens (human) | 0.02 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 1.8 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.3602 | |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | 0.76 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 0.486 | |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | 0.036 | |
| Sodium-dependent serotonin transporter | Macaca mulatta (Rhesus monkey) | 0.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (86.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hardy, KJ; McMurray, RW | 1 |
| Boehncke, WH; Gibbs, BF | 1 |
| Burian, M; Geisslinger, G | 1 |
| Møiniche, S; Rømsing, J | 1 |
| Benoit, V; de Leval, X; Dogné, JM; Frederich, M; Julémont, F; Pirotte, B | 1 |
| Furberg, CD; Psaty, BM | 1 |
| Drazen, JM | 1 |
| Meechan, J | 1 |
| Babul, N; Lipman, AG; Sloan, P | 1 |
| Nylander, O; Pihl, L | 1 |
| Deray, G; Montalescot, G; Sibilia, J | 1 |
| Arguelles, J; Cobo, J; Costales, M; de Carlos, F; Garcia, MA; Perillan, C; Vijande, M | 1 |
| Cacheux, W; Chaussade, S; de Reyniès, A; Hamzaoui, N; Lamarque, D; Perret, C; Romagnolo, B; Terris, B; Zagani, R | 1 |
| Elliott, WJ | 1 |
| Balbontín-Ayala, F; Cañigral, A; Carlos, Fd; Cobo, T; Fernández-González, FJ; Fernández-Vázquez, JP; Gonzalo-Orden, JM; Sánchez-Lasheras, F; Vega, JA | 1 |
7 review(s) available for parecoxib and rofecoxib
| Article | Year |
|---|---|
Cox-2 inhibitors: today and tomorrow.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Etoricoxib; Humans; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Research; Sulfonamides; Sulfones | 2002 |
[Clinical pharmacology of the selective COX-2 inhibitors].
Topics: Acute Disease; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Pain; Pain, Postoperative; Placebos; Pyrazoles; Sulfonamides; Sulfones | 2003 |
A systematic review of COX-2 inhibitors compared with traditional NSAIDs, or different COX-2 inhibitors for post-operative pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Lactones; Pain Measurement; Pain, Postoperative; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Sulfones; Treatment Outcome | 2004 |
First and second generations of COX-2 selective inhibitors.
Topics: Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etoricoxib; Gastrointestinal Diseases; Humans; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Sulfonamides; Sulfones | 2004 |
[What do we know about the cardiovascular toxicity of the NSAIDs?].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Case-Control Studies; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Follow-Up Studies; Humans; Isoxazoles; Lactones; Meta-Analysis as Topic; Middle Aged; Naproxen; Pyrazoles; Randomized Controlled Trials as Topic; Risk Factors; Sulfonamides; Sulfones; Thrombosis; Time Factors | 2006 |
Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Humans; Hypertension; Isoxazoles; Lactones; Pyrazoles; Pyridines; Risk; Risk Factors; Sulfonamides; Sulfones | 2010 |
Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Bone Remodeling; Celecoxib; Clodronic Acid; Diclofenac; Diphosphonates; Humans; Imidazoles; Interferon-gamma; Isoxazoles; Lactones; Mice; Orthodontic Anchorage Procedures; Osteoclasts; Osteoprotegerin; Pamidronate; Rats; Resveratrol; Stilbenes; Sulfones; Tooth Mobility; Tooth Movement Techniques; Zoledronic Acid | 2015 |
1 trial(s) available for parecoxib and rofecoxib
| Article | Year |
|---|---|
COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Ibuprofen; Injections, Intravenous; Isoxazoles; Lactones; Pain, Postoperative; Preanesthetic Medication; Prodrugs; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction | 2006 |
7 other study(ies) available for parecoxib and rofecoxib
| Article | Year |
|---|---|
Effects of rofecoxib, celecoxib, and parecoxib on anti-IgE-induced histamine release from human skin mast cells and basophils.
Topics: Antibodies, Anti-Idiotypic; Basophils; Celecoxib; Cyclooxygenase Inhibitors; Histamine Release; Humans; Isoxazoles; Lactones; Mast Cells; Pyrazoles; Skin; Sulfonamides; Sulfones | 2003 |
COX-2 inhibitors--lessons in drug safety.
Topics: Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Approval; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Publishing; Pyrazoles; Randomized Controlled Trials as Topic; Research Design; Sulfonamides; Sulfones; United States; United States Food and Drug Administration | 2005 |
COX-2 inhibitors--a lesson in unexpected problems.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Approval; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones | 2005 |
Postsurgical safety of opioid-sparing cyclooxygenase-2 inhibitors.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Lactones; Pain, Postoperative; Sulfones | 2006 |
Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery.
Topics: Animals; Bicarbonates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Duodenum; Gastrointestinal Motility; Intestinal Absorption; Intestinal Mucosa; Isoxazoles; Lactones; Laparotomy; Male; Osmolar Concentration; Perfusion; Pyrazoles; Rats; Rats, Inbred Lew; Sodium Chloride; Sulfones | 2006 |
Orthodontic tooth movement after different coxib therapies.
Topics: Alveolar Process; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cephalometry; Cyclooxygenase 2 Inhibitors; Gingiva; Isoxazoles; Lactones; Male; Molar; Orthodontic Wires; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Sulfones; Time Factors; Tooth Movement Techniques | 2007 |
Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers.
Topics: Adenomatous Polyposis Coli; Animals; Antineoplastic Agents; beta Catenin; Cell Line, Tumor; Cell Survival; Colonic Polyps; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; DNA-Binding Proteins; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, APC; Humans; Isoxazoles; Lactones; Mice; Mice, Mutant Strains; Nuclear Receptor Subfamily 4, Group A, Member 2; Oligonucleotide Array Sequence Analysis; Osteopontin; Promoter Regions, Genetic; RNA Interference; Signal Transduction; Sulfones; Time Factors; Transcription Factors; Transfection; Wnt Proteins | 2009 |