parecoxib has been researched along with ketorolac in 24 studies
| Studies (parecoxib) | Trials (parecoxib) | Recent Studies (post-2010) (parecoxib) | Studies (ketorolac) | Trials (ketorolac) | Recent Studies (post-2010) (ketorolac) |
|---|---|---|---|---|---|
| 436 | 186 | 229 | 1,778 | 668 | 725 |
| Protein | Taxonomy | parecoxib (IC50) | ketorolac (IC50) |
|---|---|---|---|
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 0.013 | |
| Caspase-1 | Homo sapiens (human) | 1.3025 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.282 | |
| Caspase-3 | Homo sapiens (human) | 1.3025 | |
| Caspase-4 | Homo sapiens (human) | 1.3025 | |
| Caspase-5 | Homo sapiens (human) | 1.3025 | |
| Caspase-9 | Homo sapiens (human) | 1.3025 | |
| Cell division control protein 42 homolog | Homo sapiens (human) | 2 | |
| Ras-related C3 botulinum toxin substrate 1 | Homo sapiens (human) | 2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (66.67) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Daniels, SE; Grossman, EH; Hubbard, RC; Kuss, ME; Talwalker, S | 1 |
| Goldstein, JL; Harris, SI; Hubbard, RC; Kuss, M | 1 |
| Dhadda, S; Harris, SI; Hubbard, RC; Kuss, ME; LeComte, D; Stoltz, RR; Talwalker, S | 1 |
| Hogue, C; Hubbard, RC; Rasmussen, GL; Steckner, K; Torri, S | 1 |
| Barton, SF; Dhadda, SS; Hubbard, RC; Kuss, ME; Langeland, FF; LeComte, D; Snabes, MC | 1 |
| Cullinane, D; Einhorn, TA; Gerstenfeld, LC; Mielke, C; Phippard, D; Seibert, K; Svagr, B; Thiede, M | 1 |
| Daniels, S; Desjardins, PJ; Hubbard, RC; Mehlisch, DR | 2 |
| Aspenberg, P | 1 |
| Jain, NK; Kulkarni, SK; Padi, SS; Singh, S | 1 |
| Emembolu, J; Ng, A; Smith, G; Temple, A | 1 |
| Harris, SI; Hubbard, RC; LeComte, D; Stoltz, RR | 1 |
| Bajwa, ZH; Bikhazi, GB; Davis, DJ; Hubbard, RC; LeComte, D; Snabes, MC; Traylor, L | 1 |
| Kulkarni, SK; Padi, SS | 1 |
| Wartell, RL | 1 |
| Barzan, L; Casati, A; Dal Sasso, M; Fanelli, G; Leykin, Y; Pellis, T; Rapotec, A | 1 |
| Cheu, NW; Chuang, FH; Liao, CH; Tan, TD; Wang, YR; Watts, MP; Wong, JO | 1 |
| Draegni, T; Heyerdahl, F; Lenz, H; Raeder, J; Schmelz, M; Stubhaug, A | 1 |
| Díaz-Ponce, H; Galindo-Suárez, RM; Muciño-Ortega, E; Walter-Tordecillas, MA | 1 |
| Cheewakidakarn, J; Nimmaanrat, S; Siribumrungwong, K; Tangtrakulwanich, B | 1 |
| Chen, CL; Cheng, KW; Huang, CJ; Jawan, B; Juang, SE; Lee, YE; Lim, KI; Liu, CK; Shih, TH; Wang, CH; Wu, SC; Yang, SC | 1 |
| de Castro Araujo, BL; de Melo, AC; de Oliveira, JL; Noguera, WS; Rezende, JFN; Thuler, LCS | 1 |
| Chinwatanawongwan, B; Chompoonutprapa, P; Laoruengthana, A; Pongpirul, K; Rattanaprichavej, P; Reosanguanwong, K | 1 |
| Ferguson, MC; McNicol, ED; Schumann, R | 1 |
1 review(s) available for parecoxib and ketorolac
| Article | Year |
|---|---|
Single-dose intravenous ketorolac for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bias; Diclofenac; Humans; Injections, Intravenous; Isoxazoles; Ketorolac; Middle Aged; Numbers Needed To Treat; Pain, Postoperative; Placebos; Randomized Controlled Trials as Topic; Time Factors; Young Adult | 2021 |
15 trial(s) available for parecoxib and ketorolac
| Article | Year |
|---|---|
A double-blind, randomized comparison of intramuscularly and intravenously administered parecoxib sodium versus ketorolac and placebo in a post-oral surgery pain model.
Topics: Adult; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Isoxazoles; Ketorolac; Male; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative | 2001 |
Upper gastrointestinal safety evaluation of parecoxib sodium, a new parenteral cyclooxygenase-2-specific inhibitor, compared with ketorolac, naproxen, and placebo.
Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Gastric Mucosa; Humans; Infusions, Parenteral; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Naproxen; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases | 2001 |
Upper GI mucosal effects of parecoxib sodium in healthy elderly subjects.
Topics: Age Factors; Aged; Confidence Intervals; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Duodenal Ulcer; Female; Gastric Mucosa; Gastroscopy; Humans; Incidence; Infusions, Intravenous; Intestinal Mucosa; Isoxazoles; Ketorolac; Male; Reference Values; Risk Assessment; Stomach Ulcer | 2002 |
Intravenous parecoxib sodium foracute pain after orthopedic knee surgery.
Topics: Aged; Analgesia; Arthroplasty, Replacement, Knee; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Isoxazoles; Ketorolac; Knee Joint; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Sensitivity and Specificity; Treatment Outcome | 2002 |
Efficacy and safety of intravenous parecoxib sodium in relieving acute postoperative pain following gynecologic laparotomy surgery.
Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Hysterectomy; Injections, Intravenous; Isoxazoles; Ketorolac; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative | 2002 |
Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery.
Topics: Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Molar, Third; Pain Measurement; Pain, Postoperative; Prodrugs; Prostaglandin-Endoperoxide Synthases; Safety; Sulfonamides; Survival Analysis; Time Factors; Tooth Extraction | 2003 |
Early analgesic effects of parecoxib versus ketorolac following laparoscopic sterilization: a randomized controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Isoxazoles; Ketorolac; Laparoscopy; Middle Aged; Pain Measurement; Pain, Postoperative; Prospective Studies; Sterilization, Tubal | 2004 |
Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects.
Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Treatment Outcome | 2004 |
A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Gynecologic Surgical Procedures; Humans; Hysterectomy; Isoxazoles; Ketorolac; Laparotomy; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative | 2004 |
The analgesic efficacy of intramuscular parecoxib sodium in postoperative dental pain.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Facial Pain; Humans; Injections, Intramuscular; Isoenzymes; Isoxazoles; Ketorolac; Membrane Proteins; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Survival Analysis; Tooth Extraction | 2004 |
A prospective, randomized, double-blind comparison between parecoxib and ketorolac for early postoperative analgesia following nasal surgery.
Topics: Adolescent; Adult; Aged; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double-Blind Method; Humans; Isoxazoles; Ketorolac; Middle Aged; Nose; Pain, Postoperative; Postoperative Care; Prospective Studies; Time Factors; Young Adult | 2008 |
Comparison of the efficacy of parecoxib versus ketorolac combined with morphine on patient-controlled analgesia for post-cesarean delivery pain management.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Cesarean Section; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Infusions, Intravenous; Isoxazoles; Ketorolac; Morphine; Pain, Postoperative; Pregnancy | 2010 |
Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans.
Topics: Adult; Analgesics, Opioid; Blood Pressure; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Humans; Hyperalgesia; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Remifentanil; Time Factors; Young Adult | 2011 |
Comparing parecoxib and ketorolac as preemptive analgesia in patients undergoing posterior lumbar spinal fusion: a prospective randomized double-blinded placebo-controlled trial.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dyspepsia; Female; Humans; Incidence; Injections, Intravenous; Isoxazoles; Ketorolac; Lumbar Vertebrae; Male; Middle Aged; Nausea; Pain, Postoperative; Prospective Studies; Spinal Fusion; Treatment Outcome | 2015 |
A randomized controlled trial comparing the efficacies of ketorolac and parecoxib for early pain management after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Knee; Blood Transfusion; Bupivacaine; Drug Therapy, Combination; Drug Utilization; Female; Humans; Injections, Intra-Articular; Isoxazoles; Ketorolac; Male; Middle Aged; Morphine; Pain, Postoperative; Prospective Studies; Visual Analog Scale | 2020 |
8 other study(ies) available for parecoxib and ketorolac
| Article | Year |
|---|---|
Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Bony Callus; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fracture Healing; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Torsion Abnormality | 2003 |
Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fracture Healing; Isoenzymes; Isoxazoles; Ketorolac; Prostaglandin-Endoperoxide Synthases; Rats | 2004 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Endotoxins; Female; Fever; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Mice; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach | 2004 |
Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Disease Models, Animal; Female; Hyperalgesia; Isoenzymes; Isoxazoles; Ketorolac; Lipopolysaccharides; Male; Mice; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Salmonella typhimurium | 2005 |
Parecoxib versus ibuprofen.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Ibuprofen; Injections, Intramuscular; Isoxazoles; Ketorolac; Pain, Postoperative; Tooth Extraction | 2005 |
[Economic analysis of parecoxib in the management of postsurgical pain in gynecology].
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Costs and Cost Analysis; Decision Trees; Female; Gynecologic Surgical Procedures; Humans; Isoxazoles; Ketorolac; Morphine; Pain, Postoperative | 2012 |
Transitional Study of Patient-Controlled Analgesia Morphine With Ketorolac to Patient-Controlled Analgesia Morphine With Parecoxib Among Donors in Adult Living Donor Liver Transplantation: A Single-Center Experience.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Humans; Isoxazoles; Ketorolac; Liver Transplantation; Living Donors; Male; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Retrospective Studies; Tissue and Organ Harvesting | 2016 |
Impact of Non-Steroidal Anti-Inflammatory Drugs on Recurrence and Survival after Melanoma Surgery: A Cohort Study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Female; Humans; Isoxazoles; Kaplan-Meier Estimate; Ketorolac; Male; Melanoma; Melanoma, Cutaneous Malignant; Middle Aged; Neoplasm Recurrence, Local; Perioperative Period; Piroxicam; Retrospective Studies; Sentinel Lymph Node Biopsy; Skin Neoplasms; Treatment Outcome | 2020 |