Page last updated: 2024-09-03

parecoxib and ketorolac

parecoxib has been researched along with ketorolac in 24 studies

Compound Research Comparison

Studies
(parecoxib)
Trials
(parecoxib)
Recent Studies (post-2010)
(parecoxib)
Studies
(ketorolac)
Trials
(ketorolac)
Recent Studies (post-2010) (ketorolac)
4361862291,778668725

Protein Interaction Comparison

ProteinTaxonomyparecoxib (IC50)ketorolac (IC50)
Prostaglandin G/H synthase 1Homo sapiens (human)0.013
Caspase-1Homo sapiens (human)1.3025
Prostaglandin G/H synthase 2Homo sapiens (human)0.282
Caspase-3Homo sapiens (human)1.3025
Caspase-4Homo sapiens (human)1.3025
Caspase-5Homo sapiens (human)1.3025
Caspase-9Homo sapiens (human)1.3025
Cell division control protein 42 homologHomo sapiens (human)2
Ras-related C3 botulinum toxin substrate 1Homo sapiens (human)2

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's16 (66.67)29.6817
2010's5 (20.83)24.3611
2020's3 (12.50)2.80

Authors

AuthorsStudies
Daniels, SE; Grossman, EH; Hubbard, RC; Kuss, ME; Talwalker, S1
Goldstein, JL; Harris, SI; Hubbard, RC; Kuss, M1
Dhadda, S; Harris, SI; Hubbard, RC; Kuss, ME; LeComte, D; Stoltz, RR; Talwalker, S1
Hogue, C; Hubbard, RC; Rasmussen, GL; Steckner, K; Torri, S1
Barton, SF; Dhadda, SS; Hubbard, RC; Kuss, ME; Langeland, FF; LeComte, D; Snabes, MC1
Cullinane, D; Einhorn, TA; Gerstenfeld, LC; Mielke, C; Phippard, D; Seibert, K; Svagr, B; Thiede, M1
Daniels, S; Desjardins, PJ; Hubbard, RC; Mehlisch, DR2
Aspenberg, P1
Jain, NK; Kulkarni, SK; Padi, SS; Singh, S1
Emembolu, J; Ng, A; Smith, G; Temple, A1
Harris, SI; Hubbard, RC; LeComte, D; Stoltz, RR1
Bajwa, ZH; Bikhazi, GB; Davis, DJ; Hubbard, RC; LeComte, D; Snabes, MC; Traylor, L1
Kulkarni, SK; Padi, SS1
Wartell, RL1
Barzan, L; Casati, A; Dal Sasso, M; Fanelli, G; Leykin, Y; Pellis, T; Rapotec, A1
Cheu, NW; Chuang, FH; Liao, CH; Tan, TD; Wang, YR; Watts, MP; Wong, JO1
Draegni, T; Heyerdahl, F; Lenz, H; Raeder, J; Schmelz, M; Stubhaug, A1
Díaz-Ponce, H; Galindo-Suárez, RM; Muciño-Ortega, E; Walter-Tordecillas, MA1
Cheewakidakarn, J; Nimmaanrat, S; Siribumrungwong, K; Tangtrakulwanich, B1
Chen, CL; Cheng, KW; Huang, CJ; Jawan, B; Juang, SE; Lee, YE; Lim, KI; Liu, CK; Shih, TH; Wang, CH; Wu, SC; Yang, SC1
de Castro Araujo, BL; de Melo, AC; de Oliveira, JL; Noguera, WS; Rezende, JFN; Thuler, LCS1
Chinwatanawongwan, B; Chompoonutprapa, P; Laoruengthana, A; Pongpirul, K; Rattanaprichavej, P; Reosanguanwong, K1
Ferguson, MC; McNicol, ED; Schumann, R1

Reviews

1 review(s) available for parecoxib and ketorolac

ArticleYear
Single-dose intravenous ketorolac for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2021, 05-17, Volume: 5

    Topics: Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bias; Diclofenac; Humans; Injections, Intravenous; Isoxazoles; Ketorolac; Middle Aged; Numbers Needed To Treat; Pain, Postoperative; Placebos; Randomized Controlled Trials as Topic; Time Factors; Young Adult

2021

Trials

15 trial(s) available for parecoxib and ketorolac

ArticleYear
A double-blind, randomized comparison of intramuscularly and intravenously administered parecoxib sodium versus ketorolac and placebo in a post-oral surgery pain model.
    Clinical therapeutics, 2001, Volume: 23, Issue:7

    Topics: Adult; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Isoxazoles; Ketorolac; Male; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative

2001
Upper gastrointestinal safety evaluation of parecoxib sodium, a new parenteral cyclooxygenase-2-specific inhibitor, compared with ketorolac, naproxen, and placebo.
    Clinical therapeutics, 2001, Volume: 23, Issue:9

    Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Gastric Mucosa; Humans; Infusions, Parenteral; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Naproxen; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases

2001
Upper GI mucosal effects of parecoxib sodium in healthy elderly subjects.
    The American journal of gastroenterology, 2002, Volume: 97, Issue:1

    Topics: Age Factors; Aged; Confidence Intervals; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Duodenal Ulcer; Female; Gastric Mucosa; Gastroscopy; Humans; Incidence; Infusions, Intravenous; Intestinal Mucosa; Isoxazoles; Ketorolac; Male; Reference Values; Risk Assessment; Stomach Ulcer

2002
Intravenous parecoxib sodium foracute pain after orthopedic knee surgery.
    American journal of orthopedics (Belle Mead, N.J.), 2002, Volume: 31, Issue:6

    Topics: Aged; Analgesia; Arthroplasty, Replacement, Knee; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Isoxazoles; Ketorolac; Knee Joint; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Sensitivity and Specificity; Treatment Outcome

2002
Efficacy and safety of intravenous parecoxib sodium in relieving acute postoperative pain following gynecologic laparotomy surgery.
    Anesthesiology, 2002, Volume: 97, Issue:2

    Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Hysterectomy; Injections, Intravenous; Isoxazoles; Ketorolac; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative

2002
Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2003, Volume: 61, Issue:9

    Topics: Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Molar, Third; Pain Measurement; Pain, Postoperative; Prodrugs; Prostaglandin-Endoperoxide Synthases; Safety; Sulfonamides; Survival Analysis; Time Factors; Tooth Extraction

2003
Early analgesic effects of parecoxib versus ketorolac following laparoscopic sterilization: a randomized controlled trial.
    British journal of anaesthesia, 2004, Volume: 92, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Isoxazoles; Ketorolac; Laparoscopy; Middle Aged; Pain Measurement; Pain, Postoperative; Prospective Studies; Sterilization, Tubal

2004
Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects.
    Journal of clinical gastroenterology, 2004, Volume: 38, Issue:7

    Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Treatment Outcome

2004
A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy.
    American journal of obstetrics and gynecology, 2004, Volume: 191, Issue:4

    Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Gynecologic Surgical Procedures; Humans; Hysterectomy; Isoxazoles; Ketorolac; Laparotomy; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative

2004
The analgesic efficacy of intramuscular parecoxib sodium in postoperative dental pain.
    Journal of the American Dental Association (1939), 2004, Volume: 135, Issue:11

    Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Facial Pain; Humans; Injections, Intramuscular; Isoenzymes; Isoxazoles; Ketorolac; Membrane Proteins; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Survival Analysis; Tooth Extraction

2004
A prospective, randomized, double-blind comparison between parecoxib and ketorolac for early postoperative analgesia following nasal surgery.
    Minerva anestesiologica, 2008, Volume: 74, Issue:9

    Topics: Adolescent; Adult; Aged; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double-Blind Method; Humans; Isoxazoles; Ketorolac; Middle Aged; Nose; Pain, Postoperative; Postoperative Care; Prospective Studies; Time Factors; Young Adult

2008
Comparison of the efficacy of parecoxib versus ketorolac combined with morphine on patient-controlled analgesia for post-cesarean delivery pain management.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2010, Volume: 48, Issue:4

    Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Cesarean Section; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Infusions, Intravenous; Isoxazoles; Ketorolac; Morphine; Pain, Postoperative; Pregnancy

2010
Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans.
    Pain, 2011, Volume: 152, Issue:6

    Topics: Adult; Analgesics, Opioid; Blood Pressure; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Humans; Hyperalgesia; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Remifentanil; Time Factors; Young Adult

2011
Comparing parecoxib and ketorolac as preemptive analgesia in patients undergoing posterior lumbar spinal fusion: a prospective randomized double-blinded placebo-controlled trial.
    BMC musculoskeletal disorders, 2015, Mar-18, Volume: 16

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dyspepsia; Female; Humans; Incidence; Injections, Intravenous; Isoxazoles; Ketorolac; Lumbar Vertebrae; Male; Middle Aged; Nausea; Pain, Postoperative; Prospective Studies; Spinal Fusion; Treatment Outcome

2015
A randomized controlled trial comparing the efficacies of ketorolac and parecoxib for early pain management after total knee arthroplasty.
    The Knee, 2020, Volume: 27, Issue:6

    Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Knee; Blood Transfusion; Bupivacaine; Drug Therapy, Combination; Drug Utilization; Female; Humans; Injections, Intra-Articular; Isoxazoles; Ketorolac; Male; Middle Aged; Morphine; Pain, Postoperative; Prospective Studies; Visual Analog Scale

2020

Other Studies

8 other study(ies) available for parecoxib and ketorolac

ArticleYear
Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2003, Volume: 21, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Bony Callus; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fracture Healing; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Torsion Abnormality

2003
Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2004, Volume: 22, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fracture Healing; Isoenzymes; Isoxazoles; Ketorolac; Prostaglandin-Endoperoxide Synthases; Rats

2004
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
    European journal of pharmacology, 2004, Apr-26, Volume: 491, Issue:1

    Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Endotoxins; Female; Fever; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Mice; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach

2004
Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test.
    Indian journal of experimental biology, 2005, Volume: 43, Issue:1

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Disease Models, Animal; Female; Hyperalgesia; Isoenzymes; Isoxazoles; Ketorolac; Lipopolysaccharides; Male; Mice; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Salmonella typhimurium

2005
Parecoxib versus ibuprofen.
    Journal of the American Dental Association (1939), 2005, Volume: 136, Issue:3

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Ibuprofen; Injections, Intramuscular; Isoxazoles; Ketorolac; Pain, Postoperative; Tooth Extraction

2005
[Economic analysis of parecoxib in the management of postsurgical pain in gynecology].
    Ginecologia y obstetricia de Mexico, 2012, Volume: 80, Issue:11

    Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Costs and Cost Analysis; Decision Trees; Female; Gynecologic Surgical Procedures; Humans; Isoxazoles; Ketorolac; Morphine; Pain, Postoperative

2012
Transitional Study of Patient-Controlled Analgesia Morphine With Ketorolac to Patient-Controlled Analgesia Morphine With Parecoxib Among Donors in Adult Living Donor Liver Transplantation: A Single-Center Experience.
    Transplantation proceedings, 2016, Volume: 48, Issue:4

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Humans; Isoxazoles; Ketorolac; Liver Transplantation; Living Donors; Male; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Retrospective Studies; Tissue and Organ Harvesting

2016
Impact of Non-Steroidal Anti-Inflammatory Drugs on Recurrence and Survival after Melanoma Surgery: A Cohort Study.
    Cancer investigation, 2020, Volume: 38, Issue:7

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Female; Humans; Isoxazoles; Kaplan-Meier Estimate; Ketorolac; Male; Melanoma; Melanoma, Cutaneous Malignant; Middle Aged; Neoplasm Recurrence, Local; Perioperative Period; Piroxicam; Retrospective Studies; Sentinel Lymph Node Biopsy; Skin Neoplasms; Treatment Outcome

2020