parecoxib has been researched along with isoxazoles in 407 studies
| Studies (parecoxib) | Trials (parecoxib) | Recent Studies (post-2010) (parecoxib) | Studies (isoxazoles) | Trials (isoxazoles) | Recent Studies (post-2010) (isoxazoles) |
|---|---|---|---|---|---|
| 436 | 186 | 229 | 8,633 | 900 | 3,337 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 169 (41.52) | 29.6817 |
| 2010's | 185 (45.45) | 24.3611 |
| 2020's | 53 (13.02) | 2.80 |
| Authors | Studies |
|---|---|
| Bertenshaw, SR; Brown, DL; Carter, JS; Graneto, MJ; Kellogg, MS; Koboldt, CM; Seibert, K; Talley, JJ; Yuan, J; Zhang, YY | 1 |
| Jain, KK | 1 |
| Cheer, SM; Goa, KL | 1 |
| Daniels, SE; Grossman, EH; Hubbard, RC; Kuss, ME; Talwalker, S | 1 |
| Baum, D; Desjardins, PJ; Dhadda, S; Grossman, EH; Hubbard, RC; Kuss, ME; Talwalker, S | 1 |
| Crosby-Sessoms, SL; Hubbard, RC; Karim, A; Kuss, ME; Laurent, A; Qian, J; Slater, ME | 1 |
| Goldstein, JL; Harris, SI; Hubbard, RC; Kuss, M | 1 |
| Feldman, J; Ibrahim, A; Karim, A; Kharasch, ED; Park, S | 1 |
| Dhadda, S; Harris, SI; Hubbard, RC; Kuss, ME; LeComte, D; Stoltz, RR; Talwalker, S | 1 |
| Hardy, KJ; McMurray, RW | 1 |
| Hogue, C; Hubbard, RC; Rasmussen, GL; Steckner, K; Torri, S | 1 |
| Barton, SF; Dhadda, SS; Hubbard, RC; Kuss, ME; Langeland, FF; LeComte, D; Snabes, MC | 1 |
| Chen, X; Kariger, R; Li, S; Naruse, R; Norel, E; Quon, R; Sloninsky, A; Tang, J; Webb, T; Wender, RH; White, PF | 1 |
| Feldman, J; Ibrahim, A; Karim, A; Kharasch, E | 1 |
| Rowbotham, DJ | 1 |
| Frölich, JC; Stichtenoth, DO | 1 |
| Dhadda, S; Hubbard, RC; Naumann, TM; Traylor, L | 1 |
| Korttila, K | 1 |
| Feldman, J; Ibrahim, AE; Karim, A; Kharasch, ED | 1 |
| Grossman, E; Hakki, SI; Hubbard, RC; Malan, TP; Marsh, G; Traylor, L | 1 |
| Davidson, AC; Ng, A; Smith, G | 1 |
| Cullinane, D; Einhorn, TA; Gerstenfeld, LC; Mielke, C; Phippard, D; Seibert, K; Svagr, B; Thiede, M | 1 |
| Alston, RP; Duke, PC; Feneck, RO; Hsu, PH; Hubbard, RC; Mangano, DT; Nussmeier, NA; Ott, E; Saidman, LJ; Snabes, MC | 1 |
| Bulut, D; Hanefeld, C; Koll, R; Liaghat, S; Miebach, T; Mügge, A | 1 |
| Daniels, S; Desjardins, PJ; Hubbard, RC; Mehlisch, DR | 2 |
| Boehncke, WH; Gibbs, BF | 1 |
| Cryer, B | 1 |
| Crane, IM; Mulhern, MG; Nema, S | 1 |
| Burian, M; Geisslinger, G | 1 |
| Cheung, RY; Cippolle, M; Fort, JG; Gan, TJ; Joshi, GP; Minkowitz, H; Schuller, R; Viscusi, ER | 1 |
| Bajaj, P; Ballary, C; Desai, A; Dongre, N; Jagtap, SA; Jain, MM; Kadam, GS; Kale, S; Lall, AD; Naikawadi, AA; Neelakandan, RS; Ram, S; Samra, SS; Shah, RR; Vijayakrishnan, M; Vyas, D | 1 |
| Katz, N | 1 |
| Jain, NK; Kulkarni, SK; Satyanarayana, PS; Singh, S | 1 |
| Amabile, CM; Spencer, AP | 1 |
| Aspenberg, P | 1 |
| Møiniche, S; Rømsing, J | 1 |
| Jain, NK; Kulkarni, SK; Padi, SS; Singh, S | 1 |
| Hubbard, RC; Noveck, RJ | 1 |
| Albrecht, S; Koppert, W; Körber, N; Schmelz, M; Schüttler, J; Sittl, R; Wehrfritz, A | 1 |
| Emembolu, J; Ng, A; Smith, G; Temple, A | 1 |
| Chen, C; Cheung, RY; Dodge, W; Fort, JG; Gan, TJ; Joshi, GP; Viscusi, E | 1 |
| Harris, SI; Hubbard, RC; LeComte, D; Stoltz, RR | 1 |
| Chen, C; Cleeland, CS; Hanna, DB; Jensen, MP; Mendoza, T | 1 |
| Benoit, V; de Leval, X; Dogné, JM; Frederich, M; Julémont, F; Pirotte, B | 1 |
| Eberhart, LH; Kranke, P; Morin, AM; Roewer, N | 1 |
| Chen, C; Cheung, RY; Gan, TJ; Hanna, DB; Joshi, GP; Zhao, SZ | 1 |
| Bajwa, ZH; Bikhazi, GB; Davis, DJ; Hubbard, RC; LeComte, D; Snabes, MC; Traylor, L | 1 |
| Engberg, G; Erhardt, C; Erhardt, S; Schwieler, L | 1 |
| Katsarka, O; Plaat, F | 1 |
| Bordel, R; Gierer, P; Gradl, G; Mittlmeier, T; Schaser, KD; Vollmar, B | 1 |
| Bajaj, P; Baliga, VP; Ballary, CC; Desai, AA; Dongre, NA | 1 |
| FitzGerald, GA; Furberg, CD; Psaty, BM | 1 |
| Taéron, C | 1 |
| Bloemendaal, AL; Borel Rinkes, IH; Kranenburg, O; Smakman, N; van Diest, P; Vogten, JM | 1 |
| Gordon, S; Hubbard, R; Malan, TP; Snabes, M | 1 |
| Looney, Y; O'Dwyer, R; O'Shea, A | 1 |
| Kulkarni, SK; Padi, SS | 1 |
| Boyce, SW; Brown, MT; Hoeft, A; Langford, RM; Nussmeier, NA; Parlow, JL; Verburg, KM; Whelton, AA | 1 |
| Furberg, CD; Psaty, BM | 1 |
| Drazen, JM | 1 |
| Wartell, RL | 1 |
| White, PF | 1 |
| Baechle, JP; Beaussier, M; Buffin, A; Didelot, JP; Goater, P; Lavazais, S; Lienhart, A; Loriferne, JF; Mosbah, A; Paugam, C; Perier, JF; Said, R; Weickmans, H | 1 |
| Dalpiaz, AS; Peterson, D | 1 |
| Bleichrodt, RP; Boerman, OC; Goldenberg, DM; Hendriks, T; Koppe, MJ; Oyen, WJ; Verhofstad, AA | 1 |
| Cheung, R; Jensen, MP; Martin, SA | 1 |
| Frade, LP; Lauretti, GR; Lima, ICPR; Pereira, NL | 1 |
| Aziz, Q; Delaney, C; Hobson, AR; Thompson, DG; Willert, RP; Woolf, CJ | 1 |
| Meechan, J | 1 |
| Bracht, H; Brückner, UB; Chkhouta, AB; Fröba, G; Hauser, B; Huber-Lang, M; Radermacher, P; Schelzig, H; Schoaff, MJ; Sträter, J; Vassilev, D | 1 |
| Aldington, S; Beasley, R; Shirtcliffe, P; Weatherall, M | 1 |
| Popov, I; Ruseva, A; Stoĭkov, S; Tablov, B; Tablov, V | 1 |
| Chaterjee, A; Khalil, MW; Macbryde, G; Marks, RR; Sarkar, PK | 1 |
| Engberg, G; Erhardt, S; Linderholm, K; Nilsson, L; Schwieler, L | 1 |
| Breivik, H; Haugen, T; Narum, J; Roald, H; Romundstad, L; Skolleborg, K; Stubhaug, A | 1 |
| Babul, N; Lipman, AG; Sloan, P | 2 |
| Balakrishnan, M; Kuriakose, R | 1 |
| Fuchs-Buder, T; Jeblick, S; Mencke, T; Pradarutti, S; Schreiber, JU | 1 |
| Indrambarya, T; Sindhvananda, W; Sriprajittichai, P; Urusopone, P | 1 |
| Arnold, G; Dirnagl, U; Reuter, U; Schuh-Hofer, S; Tayefeh, M | 1 |
| Boye, ME; Brown, MT; Joshi, GP; Langford, RM; Nussmeier, NA; Singla, NK; Verburg, KM; Whelton, AA | 1 |
| Bucher, M; Hobbhahn, J; Kees, FK; Lunz, D; Messmann, B; Rath, S; Schlitt, HJ; Zelenka, M | 1 |
| Nylander, O; Pihl, L | 1 |
| Breivik, H; Roald, H; Romundstad, L; Romundstad, PR; Skolleborg, K; Stubhaug, A | 1 |
| Gaeta, F; Quaratino, D; Romano, A; Viola, M; Volpetti, S | 1 |
| Munsterhjelm, E; Neuvonen, PJ; Niemi, TT; Rosenberg, PH; Ylikorkala, O | 1 |
| Bittner, R; Junginger, W; Kraft, B; Leroy, S; Schweizer, M | 1 |
| Biedler, A; Grundmann, U; Kreuer, S; Wilhelm, W; Wörnle, C; Wrobel, M | 1 |
| Aspenberg, P; Meunier, A | 1 |
| Djurhuus, JC; Frøkiaer, J; Jensen, BL; Nielsen, SS; Nørregaard, R; Topcu, SO; Walter, S | 1 |
| Al-Sukhun, J; Koivusalo, A; Lindqvist, C; Törnwall, J | 1 |
| Borgdorff, P; Paulus, WJ; Tangelder, GJ | 1 |
| Maxwell, M; Nathanson, M | 1 |
| Autio, V; Lindgren, L; Pirhonen, RA; Puolakka, PA; Puura, AI; Ranta, AU; Rorarius, MG | 1 |
| Coelho, AM; da Cunha, JE; de Almeida, JL; Jukemura, J; Machado, MC; Patzina, RA | 1 |
| Antonakis, PT; Georgiou, L; Katergiannakis, V; Kremastinou, F; Lagoudianakis, EE; Manouras, A; Papadima, A; Pattas, M | 1 |
| Abdalla, H; Buckley, E; Butler, M; Iohom, G; Larney, V; O'Brien, J; Shorten, GD; Szarvas, S | 1 |
| Bennett, T; Gardiner, SM; Kemp, PA; March, JE | 1 |
| Böswald, W; Frötsch, K; Griessinger, N; Huzurudin, N; Koppert, W; Schmieder, RE; Schüttler, J; Weisbach, V | 1 |
| Koppert, W; Schmelz, M; Schüttler, J; Singler, B; Sittl, R; Tröster, A | 1 |
| Deray, G; Montalescot, G; Sibilia, J | 1 |
| Joshi, C; Prasad, CN; Sharma, A; Subramaniam, R | 1 |
| Bhatia, S; Seedher, N | 1 |
| Popov, I; Stoĭkov, S; Tablov, B; Tablov, V | 1 |
| Engelman, E; Salengros, JC | 1 |
| Chang, YC; Hsieh, SP; Jean, YH; Tang, CC; Wang, YH; Wen, ZH; Wong, CS | 1 |
| Diget, M; Frøkiaer, J; Jensen, BL; Knepper, MA; Nielsen, S; Nørregaard, R; Schweer, H; Topcu, SO | 1 |
| Chizh, BA; Göhring, M; Koppert, W; Quartey, GK; Schmelz, M; Tröster, A | 1 |
| Camu, F; Joshi, GP; Schug, SA | 1 |
| Gajraj, NM | 1 |
| Beaussier, M; Lienhart, A; Sean, PT; Tilleul, P; Weickmans, H | 1 |
| Andreatini, R; da Cunha, C; Lima, MM; Machado, HB; Reksidler, AB; Tufik, S; Vital, MA; Zanata, SM | 1 |
| Britti, D; Chaterjee, PK; Collino, M; Cuzzocrea, S; Mazzon, E; Patel, NS; Thiemermann, C; Yaqoob, MM | 1 |
| Nylander, O; Sjöblom, M | 1 |
| Deva, R; Dubiel, W; Henklein, P; Hetfeld, BK; Huang, X; Mall, JW; Neuss, H; Nigam, S; Schwenk, W | 1 |
| Bouhassira, D; Chauvin, M; Fletcher, D; Martin, F | 1 |
| Belbachir, A; Chauvin, M; Cherif, K; Fletcher, D; Jaber, A; Jamal, A; Martinez, V; Ozier, Y; Sessler, DI | 1 |
| Abbate, A; Baldi, A; Biasucci, LM; Biondi-Zoccai, GG; Crea, F; Fowler, AA; Kukreja, RC; Lipinski, MJ; Ockaili, RA; Salloum, FN; Straino, S; Vetrovec, GW | 1 |
| Arabmotlagh, M; Cheung, R; Geisslinger, G; Graff, J; Harder, S | 1 |
| Bonde, RK; Jensen, BL; Madsen, K; Nielsen, FT; Skøtt, O; Stubbe, J | 1 |
| Ayar, A | 1 |
| Kamerman, P; Koller, A; Loram, L | 1 |
| Hentunen, T; Kellinsalmi, M; Lehenkari, P; Lehtonen, S; Leskelä, HV; Parikka, V; Risteli, J; Selander, K; Väänänen, K | 1 |
| Bello, A; Cheung, R; Johnston, A; Langford, RM; Mehta, V | 1 |
| Bunburaphong, P; Niruthisard, S; Toleb, K; Ussawanophakiat, M; Werawataganon, T; Wongsakornchaikul, C | 1 |
| Arguelles, J; Cobo, J; Costales, M; de Carlos, F; Garcia, MA; Perillan, C; Vijande, M | 1 |
| Brown, MT; Jakimiuk, AJ; Katz, TK; Kotarski, J; Snabes, MC; Verburg, KM | 1 |
| Deusch, E; Duris, M; Gebhardt, K; Kozek-Langenecker, S; Scharbert, G; Sow, Z | 1 |
| Nylander, O; Pihl, L; Wilander, E | 1 |
| Abbate, A; Baldi, A; Biasucci, LM; Biondi-Zoccai, GG; Capogrossi, MC; Crea, F; Das, A; Kukreja, RC; Mellone, P; Ockaili, RA; Piro, M; Qureshi, IZ; Salloum, FN; Severino, A; Straino, S; Vetrovec, GW | 1 |
| Amariles, P; Lacampa, P; Saez-Benito, L | 1 |
| Bello, A; Dreyer, S; Eikermann, M; Klassen, PD; Peters, J; Riest, G; Stegen, B; Weiss, M | 1 |
| Foocharoen, T; Jirarattanaphochai, K; Jung, S; Lertsinudom, S; Pulnitiporn, A; Sriraj, W; Thienthong, S | 1 |
| Aloia, AM; Colanardi, MC; Daprile, C; Di Leo, E; Ferrannini, A; Fitto, C; Nettis, E; Traetta, P; Vacca, A | 1 |
| Anagnostou, T; Gravas, S; Karatzas, A; Melekos, MD; Mitsogiannis, IC; Poulakis, V; Tzortzis, V | 1 |
| Candelario-Jalil, E; Fiebich, BL; Koch, FW; Seidel, MF; Ulrich-Merzenich, G; Vetter, H | 1 |
| Barzan, L; Casati, A; Dal Sasso, M; Fanelli, G; Leykin, Y; Pellis, T; Rapotec, A | 1 |
| Eichler, F; Gerbershagen, MU; Molter, G; Pantke, B; Soltesz, S | 1 |
| Barzan, L; Casati, A; Dalsasso, M; Fanelli, G; Leykin, Y; Pellis, T; Rapotec, A | 1 |
| Dimmen, S; Engebretsen, L; Madsen, JE; Nordsletten, L; Steen, H | 2 |
| Brown, MT; Gimbel, JS; Halder, AM; Snabes, M; Verburg, KM; Viscusi, ER | 1 |
| Babis, GC; Korres, DS; Nikolopoulos, K; Soucacos, PN; Tsailas, PG | 1 |
| Akritopoulos, P; Haritanti, A; Hatzokos, I; Iosifidou, E; Kotoula, M; Mirtsou-Fidani, V; Papaioannidou, P | 1 |
| Herschman, HR; Ishikawa, TO; Jain, NK; Spigelman, I | 1 |
| Bucher, M; Höcherl, K; Schmidt, C | 1 |
| Cormack, J; Jones, SJ; Murphy, MA; Scott, DA | 1 |
| Blomqvist, A; Elander, L; Engström, L; Hamzic, N; Lönn, J; Nilsberth, C; Norell, M | 1 |
| Acencio, MM; Antonangelo, L; Costa, JD; Marchi, E; Novaes, NP; Teixeira, LR; Vargas, FS | 1 |
| Herrndobler, F; Koppert, W; Maihöfner, C; Ringler, R | 1 |
| Benson, SE; Charteris, DG; Khan, I; Langford, RM; Newsom, R; Ratclliffe, S; Schlottmann, PG; Van Raders, P | 1 |
| Camu, F; Cheung, R; Joshi, GP; Pan, S; Schug, SA | 1 |
| Chambers, P; Johnson, CB; Kongara, K | 1 |
| Araujo, M; Welch, WJ | 1 |
| Dimmen, S; Engebretsen, L; Madsen, JE; Nordsletten, L | 1 |
| Dimmen, S; Madsen, JE; Nordsletten, L | 1 |
| Derry, S; Lloyd, R; McQuay, HJ; Moore, RA | 1 |
| Akaraviputh, T; Aroonpruksakul, S; Leelouhapong, C; Lohsiriwat, V | 1 |
| Abbate, A; Hoke, NN; Houser, JE; Ownby, ED; Salloum, FN; Seropian, IM; Van Tassell, BW; Varma, A | 1 |
| Harmoinen, A; Lindgren, L; Luukkaala, T; Puolakka, PA; Rintala, S; Rorarius, MG; Yli-Hankala, A | 1 |
| Avila, R; Cardenas, R; Quintero, L; Siso, A; Suarez-Roca, H; Urdaneta, A; Urdaneta, B | 1 |
| Haase, O; Koplin, G; Mall, JW; Neuss, H; Reetz, C | 1 |
| Chambers, JP; Johnson, CB; Kongara, K | 1 |
| Bosselmann, S; Chada, M; Gessner, A; Kandler, M; Nögel, SC; Rascher, W; Schmidt, AM; Schneider, H; Schweer, H; Watzer, B | 1 |
| Cacheux, W; Chaussade, S; de Reyniès, A; Hamzaoui, N; Lamarque, D; Perret, C; Romagnolo, B; Terris, B; Zagani, R | 1 |
| Bell, SN; Buchbinder, R; Coghlan, JA; Forbes, A; McKenzie, D | 1 |
| Chen, C; Chen, WH; Gan, TJ; Joshi, GP; Langford, RM; Mattera, MS; Revicki, DA; Zlateva, G | 1 |
| Abrao, MS; Alves, LM; Berardo, PT; Fernandes, PD; Landgraf, RG; Machado, DE; Nasciutti, LE; Palmero, C | 1 |
| Li, XX; Peng, YZ; Wang, YW | 1 |
| Bae, EH; Frøkiaer, J; Jensen, AM; Kim, SW; Nielsen, S; Nørregaard, R; Schweer, H; Wang, G | 1 |
| Tanavalee, A; Thiengwittayaporn, S | 1 |
| Luscombe, KS; McDonnell, NJ; Muchatuta, NA; Nathan, EA; Paech, MJ | 1 |
| Mateos, JL | 1 |
| Bala, I; Ghai, B; Makkar, JK; Wig, J | 1 |
| Bankstahl, M; Löscher, W; Polascheck, N | 1 |
| Arndt, C; Eberhart, LH; Gehling, M; Koch, T; Krüger, T; Wulf, H | 1 |
| Bhushan, A; Kaur, P; Mir, R; Sharma, S; Singh, N; Singh, TP; Sinha, M; Srinivasan, A; Vikram, G | 1 |
| Elliott, WJ | 1 |
| Dervenis, C; Kapota, E; Kostopanagiotou, G; Matsota, P; Pandazi, A; Paraskevopoulou, P | 1 |
| Cai, MX; Li, YL; Lin, HS; Peng, XM; Wu, H | 1 |
| Intapan, T; Ittichaikulthol, W; Kositchaiwat, C; Prachanpanich, N | 1 |
| Ji, FH; Jin, X; Yang, JP; Zan, LL | 1 |
| Anastasiadis, K; Argiriadou, H; Foroulis, CN; Himmelseher, S; Papagiannopoulou, P; Papakonstantinou, C; Thomaidou, E | 1 |
| Fuskevåg, OM; Reikerås, O; Shegarfi, H; Utvåg, SE | 1 |
| Brodner, G; Cosanne, I; Ellger, B; Freise, H; Gogarten, W; Hahnenkamp, K; Huppertz-Thyssen, M; Van Aken, H; Wempe, C | 1 |
| Alexandris, I; Athanasiou, K; Kyriakidis, AV; Mpesikos, I; Papadopoulos, Ch; Perysinakis, I | 1 |
| Shen, JJ; Xu, LL; Zhou, HY | 1 |
| Becker, A; Höllt, V; Schröder, H | 1 |
| Cui, C; Li, Z; Wang, Q; Wang, ZP | 1 |
| Cheu, NW; Chuang, FH; Liao, CH; Tan, TD; Wang, YR; Watts, MP; Wong, JO | 1 |
| Dimmen, S | 1 |
| Bavbek, M; Bilginer, B; Çelik, Ö; Gürgör, PN; Korkmaz, A; Özgen, T; Ziyal, İ | 1 |
| Gu, MN; Hou, XM; Liu, GW; Liu, XJ; Xiao, JF | 1 |
| Draegni, T; Heyerdahl, F; Lenz, H; Raeder, J; Schmelz, M; Stubhaug, A | 1 |
| Bartra, J; Muñoz-Cano, R; Picado, C; Roca, J; Sánchez-López, J; Serrano, C; Valero, A | 1 |
| Chen, L; Geng, D; Huang, C; Mao, H; Wang, J; Xu, Y; Yang, H; Zhu, X | 1 |
| Armstrong, PC; Emerson, M; Kirkby, NS; Mitchell, JA; Warner, TD; Zain, ZN | 1 |
| Ahn, W; Kim, YC; Kim, YH; Lee, PB; Lee, SC; Lim, YJ; Park, J | 1 |
| Del Carlo, S; Giorgi, M; Macchia, M; Manera, C; Saba, A; Saccomanni, G | 1 |
| Horn, EH; Janssens, MC; Kelly, KP; Ross, J | 1 |
| Leslie, K; Pemberton, E; Williams, DL | 1 |
| Guo, Q; Wang, E; Wang, N; Xia, P; Ye, Z; Yuan, Y | 1 |
| Cebrián, C; Conde, B; Esquivias, P; Esteva, F; Jiménez, P; Lanas, A; Ortego, J; Piazuelo, E; Santander, S | 1 |
| Ji, JQ; Li, HY; Ma, WT; Yu, W; Zhou, GB | 1 |
| Guo, QL; Wang, E; Wang, N; Xia, PP; Ye, Z; Yuan, YJ | 1 |
| Dahl, V; Raeder, JC; Spreng, UJ; Waage, M | 1 |
| Del Carlo, S; Giorgi, M; Lavy, E; Manera, C; Saccomanni, G | 1 |
| Phaloprakarn, C; Ratchanon, S; Traipak, K | 1 |
| Bakonyi, A; Goncalves, I; Naresse, LE | 1 |
| Badn, W; Darabi, A; Eberstål, S; Esbjörnsson, M; Fritzell, S; Siesjö, P; Visse, E | 1 |
| Dávila, I; González, A; Laffond, E; Moreno, E; Muñoz-Bellido, F; Ponce, V | 1 |
| Nylander, O; Sedin, J; Sjöblom, M | 1 |
| Ilett, KF; Muchatuta, NA; O'Halloran, SJ; Paech, MJ; Salman, S | 1 |
| Frøkiær, J; Jensen, BL; Madsen, K; Nilsson, L; Nørregaard, R; Topcu, SO | 1 |
| Chen, G; Gong, M; Wang, HM; Xu, LH; Yan, M; Zhang, XM | 1 |
| Davies, K; Hullett, B; Ilett, KF; O'Halloran, SJ; Peirce, D; Salman, S | 1 |
| He, G; Liu, Z; Lu, H; Ma, H; Wang, J | 1 |
| Liu, J; Xiang, Y; Zhang, Y | 1 |
| Abdulla, S; Abdulla, W; Eckhardt, R; Netter, U | 2 |
| Dong, N; Gui, P; Purusram, G; Wang, H; Wu, Q; Xie, W; Yao, S; Yuan, R | 1 |
| Chen, C; Peng, M; Wang, CY; Wang, FF; Wang, YL | 1 |
| Cao, M; Liu, K; Shu, H; Xiao, L; Yang, L; Zhang, H; Zhang, J; Zhang, X | 1 |
| Liu, X; Lou, J; Shen, X; Wang, Y; Zhao, X | 1 |
| Bao, Y; Fang, J; Li, W; Liu, K; Luo, H; Peng, L; Yi, Y | 1 |
| Guo, Q; Liao, J; Wang, E; Wang, N; Xia, P; Ye, Z | 1 |
| Becker, A; Geisslinger, G; Grecksch, G; Höllt, V; Murín, R; Schröder, H; Zimmer, A | 1 |
| Díaz-Ponce, H; Galindo-Suárez, RM; Muciño-Ortega, E; Walter-Tordecillas, MA | 1 |
| Wang, S; Wu, H; Wu, Y; Zhu, Y | 1 |
| Li, H; Nong, L; Sun, Y; Tian, Y | 1 |
| Jirarattanaphochai, K; Sae-Jung, S | 1 |
| Kasakov, L; Kraevsky, P; Vlaskovska, M | 1 |
| Athanasakis, K; Kyriopoulos, J; Petrakis, I; Pimenidou, A; Vitsou, E | 1 |
| Arung, W; Cheramy, JP; Defraigne, JO; Detry, O; Drion, P; Honoré, P; Jehaes, F; Meurisse, M | 1 |
| Chu, QJ; Liu, CL; Xie, GL | 1 |
| Darabi, A; Eberstål, S; Fritzell, S; Sandén, E; Siesjö, P; Visse, E | 1 |
| Li, W; Li, X; Xia, Q; Zhang, Y; Zhou, M | 1 |
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32 review(s) available for parecoxib and isoxazoles
| Article | Year |
|---|---|
Evaluation of intravenous parecoxib for the relief of acute post-surgical pain.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain, Postoperative; Prodrugs; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2000 |
Cox-2 inhibitors: today and tomorrow.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Etoricoxib; Humans; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Research; Sulfonamides; Sulfones | 2002 |
COX-2-selective inhibitors: clinical relevance in surgical and acute pain.
Topics: Acute Disease; Analgesics; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
The second generation of COX-2 inhibitors: what advantages do the newest offer?
Topics: Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Etoricoxib; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Organic Chemicals; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfonamides; Sulfones | 2003 |
The role of cyclooxygenase selective inhibitors in the gastrointestinal tract.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Etoricoxib; Humans; Isoxazoles; Pyridines; Sulfonamides; Sulfones; Ulcer | 2003 |
[Clinical pharmacology of the selective COX-2 inhibitors].
Topics: Acute Disease; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Pain; Pain, Postoperative; Placebos; Pyrazoles; Sulfonamides; Sulfones | 2003 |
Parecoxib for parenteral analgesia in postsurgical patients.
Topics: Cyclooxygenase Inhibitors; Drug Interactions; Humans; Injections, Intramuscular; Injections, Intravenous; Isoxazoles; Pain, Postoperative; Randomized Controlled Trials as Topic | 2004 |
A systematic review of COX-2 inhibitors compared with traditional NSAIDs, or different COX-2 inhibitors for post-operative pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Lactones; Pain Measurement; Pain, Postoperative; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Sulfones; Treatment Outcome | 2004 |
First and second generations of COX-2 selective inhibitors.
Topics: Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etoricoxib; Gastrointestinal Diseases; Humans; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Sulfonamides; Sulfones | 2004 |
Patients' global evaluation of analgesia and safety of injected parecoxib for postoperative pain: a quantitative systematic review.
Topics: Analgesia; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Pain, Postoperative; Randomized Controlled Trials as Topic | 2004 |
Parecoxib: a shift in pain management?
Topics: Animals; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Pain; Pain Measurement | 2004 |
Increased risk of cardiovascular events with parecoxib/valdecoxib: a systematic review and meta-analysis.
Topics: Cardiac Surgical Procedures; Cardiovascular Diseases; Cerebrovascular Disorders; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Myocardial Infarction; Odds Ratio; Outcome and Process Assessment, Health Care; Pain, Postoperative; Risk Factors; Sulfonamides; Survival Analysis | 2005 |
[What do we know about the cardiovascular toxicity of the NSAIDs?].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Case-Control Studies; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Follow-Up Studies; Humans; Isoxazoles; Lactones; Meta-Analysis as Topic; Middle Aged; Naproxen; Pyrazoles; Randomized Controlled Trials as Topic; Risk Factors; Sulfonamides; Sulfones; Thrombosis; Time Factors | 2006 |
COX-2 inhibitors celecoxib and parecoxib: valuable options for postoperative pain management.
Topics: Celecoxib; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Pain, Postoperative; Pyrazoles; Sulfonamides; Treatment Outcome | 2007 |
Cardiovascular safety of the cyclooxygenase-2 selective inhibitors parecoxib and valdecoxib in the postoperative setting: an analysis of integrated data.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Cyclooxygenase 2 Inhibitors; Female; Humans; Incidence; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Postoperative Care; Risk Assessment; Risk Factors; Sulfonamides; Thromboembolism; Young Adult | 2009 |
Intravenous or intramuscular parecoxib for acute postoperative pain in adults.
Topics: Acute Disease; Adult; Cyclooxygenase 2 Inhibitors; Humans; Injections, Intramuscular; Injections, Intravenous; Isoxazoles; Pain, Postoperative; Randomized Controlled Trials as Topic | 2009 |
[Selective inhibitors of cyclooxygenase-2 (COX-2), celecoxib and parecoxib: a systematic review].
Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Administration Routes; Evidence-Based Medicine; Humans; Inflammation; Isoxazoles; Pain; Pain Measurement; Pyrazoles; Structure-Activity Relationship; Sulfonamides; Treatment Outcome | 2010 |
Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Humans; Hypertension; Isoxazoles; Lactones; Pyrazoles; Pyridines; Risk; Risk Factors; Sulfonamides; Sulfones | 2010 |
What's new in NSAID pharmacotherapy: oral agents to injectables.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Humans; Hyaluronic Acid; Hydrogen Sulfide; Ibuprofen; Injections; Injections, Intra-Articular; Isoxazoles; Nanoparticles; Naproxen; Nitric Oxide Donors; Vasodilator Agents | 2013 |
Efficacy and safety of perioperative parecoxib for acute postoperative pain treatment in children: a meta-analysis.
Topics: Child; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Pain Management; Pain, Postoperative; Perioperative Care; Randomized Controlled Trials as Topic; Surgical Procedures, Operative | 2015 |
Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Bone Remodeling; Celecoxib; Clodronic Acid; Diclofenac; Diphosphonates; Humans; Imidazoles; Interferon-gamma; Isoxazoles; Lactones; Mice; Orthodontic Anchorage Procedures; Osteoclasts; Osteoprotegerin; Pamidronate; Rats; Resveratrol; Stilbenes; Sulfones; Tooth Mobility; Tooth Movement Techniques; Zoledronic Acid | 2015 |
Risk of perioperative bleeding related to highly selective cyclooxygenase-2 inhibitors: A systematic review and meta-analysis.
Topics: Blood Loss, Surgical; Celecoxib; Cyclooxygenase 2 Inhibitors; Etoricoxib; Humans; Isoxazoles; Postoperative Hemorrhage; Pyridines; Risk Factors; Sulfones | 2017 |
Efficacy of parecoxib sodium on postoperative shivering: meta-analysis of clinical trials.
Topics: Analgesics, Opioid; Anesthesia, General; Antiemetics; Clinical Trials as Topic; Humans; Isoxazoles; Meperidine; Odds Ratio; Postoperative Nausea and Vomiting; Postoperative Period; Surgical Procedures, Operative | 2018 |
Efficacy and Safety of Postoperative Pain Relief by Parecoxib Injection after Laparoscopic Surgeries: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Topics: Cyclooxygenase 2 Inhibitors; Denmark; Humans; Isoxazoles; Laparoscopy; Pain Management; Pain, Postoperative; Randomized Controlled Trials as Topic | 2018 |
The efficacy and safety of parecoxib for reducing pain and opioid consumption following total knee arthroplasty: A meta-analysis of randomized controlled trials.
Topics: Administration, Intravenous; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Male; Pain Management; Pain Measurement; Pain, Postoperative; Randomized Controlled Trials as Topic; Treatment Outcome | 2018 |
Pain Relief by Parecoxib for Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials.
Topics: Cholecystectomy, Laparoscopic; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Morphine; Pain Measurement; Pain, Postoperative; Publication Bias; Randomized Controlled Trials as Topic | 2018 |
Effect of parecoxib in the treatment of postoperative cognitive dysfunction: A systematic review and meta-analysis.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Cyclooxygenase 2 Inhibitors; Female; Humans; Interleukin-6; Isoxazoles; Male; Postoperative Complications; S100 Calcium Binding Protein beta Subunit; Time Factors; Treatment Outcome | 2019 |
The Impact of Parecoxib on Pain Management for Laparoscopic Cholecystectomy: A Meta-analysis of Randomized Controlled Trials.
Topics: Adult; Cholecystectomy, Laparoscopic; Cyclooxygenase 2 Inhibitors; Female; Humans; Infusions, Intravenous; Isoxazoles; Male; Middle Aged; Pain Management; Pain, Postoperative; Randomized Controlled Trials as Topic; Treatment Outcome | 2019 |
The efficacy of parecoxib for pain control after hysterectomy: a meta-analysis of randomized controlled studies.
Topics: Female; Humans; Hysterectomy; Isoxazoles; Pain Management; Pain, Postoperative; Randomized Controlled Trials as Topic | 2021 |
Intravenous parecoxib for early postoperative cognitive dysfunction in elderly patients: evidence from a meta-analysis.
Topics: Aged; Animals; Asian People; Cyclooxygenase 2 Inhibitors; Humans; Inflammation; Isoxazoles; Postoperative Cognitive Complications; Randomized Controlled Trials as Topic | 2020 |
Single-dose intravenous ketorolac for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bias; Diclofenac; Humans; Injections, Intravenous; Isoxazoles; Ketorolac; Middle Aged; Numbers Needed To Treat; Pain, Postoperative; Placebos; Randomized Controlled Trials as Topic; Time Factors; Young Adult | 2021 |
The efficacy of parecoxib in improving pain after total knee or total hip arthroplasty: Systematic review and meta-analysis.
Topics: Aged; Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Morphine; Nausea; Pain, Postoperative; Vomiting | 2022 |
177 trial(s) available for parecoxib and isoxazoles
| Article | Year |
|---|---|
A double-blind, randomized comparison of intramuscularly and intravenously administered parecoxib sodium versus ketorolac and placebo in a post-oral surgery pain model.
Topics: Adult; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Isoxazoles; Ketorolac; Male; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative | 2001 |
A pharmacokinetic study of intramuscular (i.m.) parecoxib sodium in normal subjects.
Topics: Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cyclooxygenase Inhibitors; Double-Blind Method; Humans; Injections, Intramuscular; Isoxazoles; Male; Middle Aged; Sulfonamides | 2001 |
Upper gastrointestinal safety evaluation of parecoxib sodium, a new parenteral cyclooxygenase-2-specific inhibitor, compared with ketorolac, naproxen, and placebo.
Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Gastric Mucosa; Humans; Infusions, Parenteral; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Naproxen; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases | 2001 |
Effects of parecoxib, a parenteral COX-2-specific inhibitor, on the pharmacokinetics and pharmacodynamics of propofol.
Topics: Adult; Anesthetics, Intravenous; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Electroencephalography; Female; Humans; Isoxazoles; Male; Propofol; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 2002 |
Upper GI mucosal effects of parecoxib sodium in healthy elderly subjects.
Topics: Age Factors; Aged; Confidence Intervals; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Duodenal Ulcer; Female; Gastric Mucosa; Gastroscopy; Humans; Incidence; Infusions, Intravenous; Intestinal Mucosa; Isoxazoles; Ketorolac; Male; Reference Values; Risk Assessment; Stomach Ulcer | 2002 |
Intravenous parecoxib sodium foracute pain after orthopedic knee surgery.
Topics: Aged; Analgesia; Arthroplasty, Replacement, Knee; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Isoxazoles; Ketorolac; Knee Joint; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Sensitivity and Specificity; Treatment Outcome | 2002 |
Efficacy and safety of intravenous parecoxib sodium in relieving acute postoperative pain following gynecologic laparotomy surgery.
Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Hysterectomy; Injections, Intravenous; Isoxazoles; Ketorolac; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative | 2002 |
Effect of parecoxib, a novel intravenous cyclooxygenase type-2 inhibitor, on the postoperative opioid requirement and quality of pain control.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Humans; Isoxazoles; Middle Aged; Morphine; Pain, Postoperative | 2002 |
The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam.
Topics: Adult; Area Under Curve; Biotransformation; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Electroencephalography; Female; Half-Life; Humans; Hypnotics and Sedatives; Injections, Intravenous; Isoxazoles; Male; Midazolam; Mixed Function Oxygenases; Nausea; Reflex; Vomiting | 2002 |
Parecoxib sodium has opioid-sparing effects in patients undergoing total knee arthroplasty under spinal anaesthesia.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anesthesia, Spinal; Arthroplasty, Replacement, Knee; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain, Postoperative; Patient Satisfaction | 2003 |
Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.
Topics: Adult; Affect; Alfentanil; Algorithms; Analgesics, Opioid; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cross-Over Studies; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP3A; Double-Blind Method; Drug Interactions; Female; Fentanyl; Half-Life; Hemodynamics; Humans; Isoxazoles; Liver; Male; Mass Spectrometry; Oxidoreductases, N-Demethylating; Pupil; Respiratory Mechanics; Troleandomycin | 2003 |
Parecoxib sodium, a parenteral cyclooxygenase 2 selective inhibitor, improves morphine analgesia and is opioid-sparing following total hip arthroplasty.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases | 2003 |
Analgesic effects of parecoxib following total abdominal hysterectomy.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hysterectomy; Isoxazoles; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Postoperative Nausea and Vomiting | 2003 |
Efficacy and safety of the cyclooxygenase 2 inhibitors parecoxib and valdecoxib in patients undergoing coronary artery bypass surgery.
Topics: Administration, Oral; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Coronary Artery Bypass; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Morphine; Pain Measurement; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Safety; Sulfonamides | 2003 |
Selective cyclo-oxygenase-2 inhibition with parecoxib acutely impairs endothelium-dependent vasodilatation in patients with essential hypertension.
Topics: Acetylcholine; Adult; Aged; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Female; Forearm; Humans; Hypertension; Isoenzymes; Isoxazoles; Lysine; Male; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Regional Blood Flow; Vasodilation; Vasodilator Agents | 2003 |
Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery.
Topics: Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Molar, Third; Pain Measurement; Pain, Postoperative; Prodrugs; Prostaglandin-Endoperoxide Synthases; Safety; Sulfonamides; Survival Analysis; Time Factors; Tooth Extraction | 2003 |
Effective treatment of laparoscopic cholecystectomy pain with intravenous followed by oral COX-2 specific inhibitor.
Topics: Administration, Oral; Adult; Cholecystectomy, Laparoscopic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2004 |
Parecoxib sodium, an injectable COX-2-specific inhibitor, does not affect unfractionated heparin-regulated blood coagulation parameters.
Topics: Adult; Blood Coagulation Factors; Cyclooxygenase 2; Drug Administration Schedule; Drug Therapy, Combination; Heparin; Humans; Infusions, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Partial Thromboplastin Time; Platelet Count; Prostaglandin-Endoperoxide Synthases; Prothrombin Time | 2004 |
The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Electric Stimulation; Humans; Hyperalgesia; Isoenzymes; Isoxazoles; Membrane Proteins; Physical Stimulation; Prostaglandin-Endoperoxide Synthases | 2004 |
Early analgesic effects of parecoxib versus ketorolac following laparoscopic sterilization: a randomized controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Isoxazoles; Ketorolac; Laparoscopy; Middle Aged; Pain Measurement; Pain, Postoperative; Prospective Studies; Sterilization, Tubal | 2004 |
Preoperative parenteral parecoxib and follow-up oral valdecoxib reduce length of stay and improve quality of patient recovery after laparoscopic cholecystectomy surgery.
Topics: Administration, Oral; Analysis of Variance; Cholecystectomy, Laparoscopic; Double-Blind Method; Female; Humans; Isoxazoles; Length of Stay; Male; Middle Aged; Multivariate Analysis; Postoperative Care; Preoperative Care; Sulfonamides | 2004 |
Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects.
Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Treatment Outcome | 2004 |
The analgesic effects that underlie patient satisfaction with treatment.
Topics: Adult; Analgesics; Cholecystectomy, Laparoscopic; Double-Blind Method; Drug Administration Routes; Drug Administration Schedule; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Outcome Assessment, Health Care; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Postoperative Care; Preoperative Care; Prospective Studies; Retrospective Studies; Sex Factors; Sulfonamides; Time Factors | 2004 |
Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Cholecystectomy, Laparoscopic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Hydrocodone; Injections, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2004 |
A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Gynecologic Surgical Procedures; Humans; Hysterectomy; Isoxazoles; Ketorolac; Laparotomy; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative | 2004 |
The analgesic efficacy of intramuscular parecoxib sodium in postoperative dental pain.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Facial Pain; Humans; Injections, Intramuscular; Isoenzymes; Isoxazoles; Ketorolac; Membrane Proteins; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Survival Analysis; Tooth Extraction | 2004 |
Role of parecoxib in pre-emptive analgesia: comparison of the efficacy and safety of pre- and postoperative parecoxib in patients undergoing general surgery.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Cyclooxygenase Inhibitors; Female; Humans; Isoxazoles; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Postoperative Care; Preoperative Care; Prospective Studies | 2004 |
The cyclooxygenase-2-specific inhibitor parecoxib sodium is as effective as 12 mg of morphine administered intramuscularly for treating pain after gynecologic laparotomy surgery.
Topics: Adult; Analgesics, Opioid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Gynecologic Surgical Procedures; Humans; Injections, Intramuscular; Isoxazoles; Laparoscopy; Membrane Proteins; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases | 2005 |
Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery.
Topics: Administration, Oral; Adult; Aged; Cardiovascular Diseases; Coronary Artery Bypass; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Infusions, Intravenous; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Sulfonamides | 2005 |
A randomized, double-blind comparison between parecoxib sodium and propacetamol for parenteral postoperative analgesia after inguinal hernia repair in adult patients.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Hernia, Inguinal; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain, Postoperative; Prospective Studies | 2005 |
The meaning of pain relief in a clinical trial.
Topics: Administration, Oral; Adult; Analgesia; Analgesics; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Isoxazoles; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Sulfonamides; Treatment Outcome | 2005 |
Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity.
Topics: Adult; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Administration Schedule; Electric Stimulation; Esophagus; Female; Humans; Hydrochloric Acid; Isoxazoles; Male; Middle Aged; Pain Threshold; Sulfonamides; Viscera | 2006 |
COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Ibuprofen; Injections, Intravenous; Isoxazoles; Lactones; Pain, Postoperative; Preanesthetic Medication; Prodrugs; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction | 2006 |
Single dose parecoxib significantly improves ventilatory function in early extubation coronary artery bypass surgery: a prospective randomized double blind placebo controlled trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Carbon Dioxide; Coronary Artery Bypass; Creatinine; Cyclooxygenase 2 Inhibitors; Device Removal; Double-Blind Method; Drug Administration Schedule; Fluid Therapy; Humans; Intubation, Intratracheal; Isoxazoles; Kidney; Middle Aged; Morphine; Pain, Postoperative; Postoperative Care; Respiration | 2006 |
Methylprednisolone reduces pain, emesis, and fatigue after breast augmentation surgery: a single-dose, randomized, parallel-group study with methylprednisolone 125 mg, parecoxib 40 mg, and placebo.
Topics: Adult; Analgesics; Anti-Inflammatory Agents; Breast Implants; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Fatigue; Female; Glucocorticoids; Humans; Isoxazoles; Mammaplasty; Methylprednisolone; Middle Aged; Postoperative Nausea and Vomiting | 2006 |
Does preoperatively administered parecoxib prevent succinylcholine-associated myalgia? A randomized, placebo-controlled trial.
Topics: Adult; Female; Humans; Isoxazoles; Male; Middle Aged; Muscular Diseases; Pain Measurement; Preoperative Care; Succinylcholine | 2006 |
Parecoxib versus tramadol for post-appendectomy pain.
Topics: Adult; Analgesics, Opioid; Appendectomy; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Meperidine; Pain, Postoperative; Tramadol; Treatment Outcome | 2005 |
Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery.
Topics: Adult; Aged; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain, Postoperative; Sulfonamides | 2006 |
Prostaglandin I2 release following mesenteric traction during abdominal surgery is mediated by cyclooxygenase-1.
Topics: 6-Ketoprostaglandin F1 alpha; Abdomen; Blood Pressure; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Epoprostenol; Female; Flushing; Heart Rate; Humans; Hypotension; Intraoperative Complications; Isoxazoles; Laparoscopy; Male; Middle Aged; Oxygen; Prospective Studies; Sulfonamides; Surgical Procedures, Operative; Tachycardia; Time Factors; Treatment Outcome | 2006 |
Chronic pain and sensory changes after augmentation mammoplasty: long term effects of preincisional administration of methylprednisolone.
Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents; Chronic Disease; Cyclooxygenase Inhibitors; Differential Threshold; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoxazoles; Mammaplasty; Methylprednisolone; Middle Aged; Pain Measurement; Pain, Postoperative; Prospective Studies; Time; Time Factors; Treatment Outcome | 2006 |
Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers.
Topics: Acetaminophen; Adenosine Diphosphate; Adult; Analgesics, Non-Narcotic; Arachidonic Acid; Blood Platelets; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Epinephrine; Humans; Infusions, Intravenous; Isoxazoles; Male; Platelet Aggregation; Thromboxane B2 | 2006 |
[Analgesia in colon surgery. Can the use of NSAIDs reduce the opioid consumption following conventional and laparoscopic interventions?].
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Isoxazoles; Laparoscopy; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Pirinitramide; Prospective Studies; Rectal Diseases; Sulfonamides | 2006 |
The efficacy of the non-opioid analgesics parecoxib, paracetamol and metamizol for postoperative pain relief after lumbar microdiscectomy.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dipyrone; Diskectomy; Double-Blind Method; Female; Humans; Isoxazoles; Lumbar Vertebrae; Male; Microsurgery; Middle Aged; Pain Measurement; Pain, Postoperative | 2006 |
Lack of analgesic effect of parecoxib following laparoscopic cholecystectomy.
Topics: Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Cholecystectomy, Laparoscopic; Double-Blind Method; Female; Fentanyl; Humans; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Prospective Studies | 2006 |
Parecoxib vs. lornoxicam in the treatment of postoperative pain after laparoscopic cholecystectomy: a prospective randomized placebo-controlled trial.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cholecystectomy, Laparoscopic; Cyclooxygenase Inhibitors; Elective Surgical Procedures; Female; Humans; Isoxazoles; Male; Meperidine; Middle Aged; Pain Measurement; Pain, Postoperative; Piroxicam; Placebos; Prospective Studies; Time Factors; Treatment Outcome | 2007 |
The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery.
Topics: Acetaminophen; Adult; Aged; Analgesia; Anxiety; Breast Neoplasms; Bupivacaine; Celecoxib; Chronic Disease; Depression; Dextropropoxyphene; Diclofenac; Female; Humans; Isoxazoles; Mastectomy; Middle Aged; Morphine; Nerve Block; Nitric Oxide; Nociceptors; Pain Measurement; Pain, Postoperative; Pyrazoles; Sulfonamides | 2006 |
The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery.
Topics: Acetaminophen; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Isoxazoles; Kidney; Kidney Function Tests; Male; Metabolic Clearance Rate; Orthopedic Procedures; Prospective Studies | 2006 |
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
Topics: Adult; Analgesia; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Humans; Hyperalgesia; Infusions, Intravenous; Isoxazoles; Ketamine; Male; Middle Aged; Pain Threshold; Piperidines; Remifentanil | 2006 |
Analgesic efficacy of single-dose parecoxib for corneal suturing in children.
Topics: Adolescent; Analgesia; Anesthetics, Intravenous; Anesthetics, Local; Child; Cornea; Corneal Injuries; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Synergism; Fentanyl; Humans; Isoxazoles; Pain Measurement; Pain, Postoperative; Propoxycaine; Suture Techniques; Treatment Outcome | 2007 |
[Usage of the new parenteral selective cox-2 inhibitor dynastat in the gynecologic practice].
Topics: Adolescent; Adult; Aged; Cyclooxygenase 2 Inhibitors; Female; Gynecologic Surgical Procedures; Humans; Infusions, Intravenous; Isoxazoles; Middle Aged; Pain Measurement; Pain, Postoperative; Prospective Studies | 2006 |
Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers.
Topics: Administration, Oral; Adult; Analgesics; Aprepitant; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Electric Stimulation; Female; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Isoxazoles; Male; Middle Aged; Morpholines; Pain Measurement; Pregabalin; Treatment Outcome | 2007 |
Cost analysis applied to postoperative analgesia regimens: a comparison between parecoxib and propacetamol.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cost-Benefit Analysis; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Hernia, Inguinal; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Morphine; Pain, Postoperative; Patient Satisfaction; Prospective Studies | 2007 |
Constitutive cyclooxygenase-2 is involved in central nociceptive processes in humans.
Topics: Adult; Cross-Over Studies; Cyclooxygenase 2; Double-Blind Method; Female; Humans; Isoxazoles; Male; Pain; Pain Threshold; Reflex; Spinal Cord | 2007 |
The influence of timing of administration on the analgesic efficacy of parecoxib in orthopedic surgery.
Topics: Aged; Analgesia; Arthroplasty, Replacement, Hip; Female; Humans; Isoxazoles; Male; Middle Aged; Orthopedic Procedures; Pain, Postoperative; Time Factors | 2007 |
Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Child; Cyclooxygenase Inhibitors; Dipyrone; Double-Blind Method; Drug Therapy, Combination; Enoxaparin; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Platelet Aggregation; Thromboxane B2 | 2007 |
Intravenous parecoxib rapidly leads to COX-2 inhibitory concentration of valdecoxib in the central nervous system.
Topics: Aged; Central Nervous System; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Humans; Inhibitory Concentration 50; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Sulfonamides; Time Factors | 2008 |
Improving the analgesic efficacy of intrathecal morphine with parecoxib after total abdominal hysterectomy.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hysterectomy; Injections, Intravenous; Injections, Spinal; Isoxazoles; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Prospective Studies; Treatment Outcome | 2007 |
Parecoxib sodium administered over several days reduces pain after gynecologic surgery via laparotomy.
Topics: Adult; Aged; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Gynecologic Surgical Procedures; Humans; Isoxazoles; Laparotomy; Middle Aged; Pain, Postoperative | 2007 |
Point-of-care platelet function tests: detection of platelet inhibition induced by nonopioid analgesic drugs.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; False Positive Reactions; Female; Humans; Isoxazoles; Low Back Pain; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Point-of-Care Systems; Thrombelastography | 2007 |
Preventive effects of perioperative parecoxib on post-discectomy pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclooxygenase Inhibitors; Diskectomy; Double-Blind Method; Drug Administration Schedule; Humans; Isoxazoles; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Perioperative Care; Postoperative Care; Preanesthetic Medication; Prospective Studies | 2008 |
Effect of parecoxib on postoperative pain after lumbar spine surgery: a bicenter, randomized, double-blinded, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Cyclooxygenase Inhibitors; Decompression, Surgical; Diskectomy; Drug Therapy, Combination; Humans; Isoxazoles; Lumbar Vertebrae; Middle Aged; Morphine; Orthopedic Procedures; Pain Measurement; Pain, Postoperative; Spinal Fusion; Treatment Outcome | 2008 |
Safety of parecoxib in patients with nonsteroidal anti-inflammatory drug-induced urticaria or angioedema.
Topics: Adolescent; Adult; Aged; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Cross Reactions; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Female; Humans; Isoxazoles; Male; Middle Aged; Single-Blind Method; Treatment Outcome; Urticaria | 2008 |
Analgesia during extracorporeal shockwave lithotripsy: fentanyl citrate versus parecoxib sodium.
Topics: Adult; Aged; Analgesics, Opioid; Cyclooxygenase Inhibitors; Female; Fentanyl; Humans; Isoxazoles; Lithotripsy; Male; Middle Aged; Pain | 2008 |
A prospective, randomized, double-blind comparison between parecoxib and ketorolac for early postoperative analgesia following nasal surgery.
Topics: Adolescent; Adult; Aged; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double-Blind Method; Humans; Isoxazoles; Ketorolac; Middle Aged; Nose; Pain, Postoperative; Postoperative Care; Prospective Studies; Time Factors; Young Adult | 2008 |
Parecoxib versus dipyrone (metamizole) for postoperative pain relief after hysterectomy : a prospective, single-centre, randomized, double-blind trial.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dipyrone; Double-Blind Method; Female; Humans; Hysterectomy, Vaginal; Injections, Intravenous; Isoxazoles; Middle Aged; Pain Measurement; Pain, Postoperative; Pirinitramide; Prospective Studies; Time Factors | 2008 |
Comparison of parecoxib and proparacetamol in endoscopic nasal surgery patients.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cyclooxygenase Inhibitors; Double-Blind Method; Endoscopy; Female; Humans; Infusions, Intravenous; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Nasal Polyps; Pain, Postoperative; Prodrugs; Prospective Studies; Sinusitis; Treatment Outcome | 2008 |
A multiple-day regimen of parecoxib sodium 20 mg twice daily provides pain relief after total hip arthroplasty.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Arthroplasty, Replacement, Hip; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Administration Schedule; Female; Humans; Isoxazoles; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction | 2008 |
Parecoxib for analgesia after craniotomy.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Craniotomy; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Prospective Studies; Young Adult | 2009 |
[Modulation of cortical pain processing by cyclooxygenase inhibition: a functional MRI study].
Topics: Acute Disease; Adult; Analgesics; Aspirin; Brain Mapping; Cerebral Cortex; Cyclooxygenase Inhibitors; Dominance, Cerebral; Double-Blind Method; Female; Frontal Lobe; Gyrus Cinguli; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Isoxazoles; Magnetic Resonance Imaging; Male; Motor Cortex; Pain; Pain Measurement; Pain Threshold; Parietal Lobe; Psychophysics; Somatosensory Cortex | 2009 |
A randomized comparison of parecoxib/valdecoxib and placebo for the prevention of cystoid macular edema after scleral buckling surgery.
Topics: Administration, Oral; Adolescent; Adult; Aged; Contrast Sensitivity; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Fluorescein Angiography; Humans; Incidence; Isoxazoles; Macular Edema; Male; Middle Aged; Prospective Studies; Retinal Detachment; Scleral Buckling; Subretinal Fluid; Sulfonamides; Tomography, Optical Coherence; Visual Acuity; Young Adult | 2009 |
Glomerular filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs.
Topics: Analgesics; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Dogs; Glomerular Filtration Rate; Isoxazoles; Morphine; Pindolol; Tramadol | 2009 |
Efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy: a prospective, randomized study.
Topics: Adult; Aged; Analgesics, Opioid; Cholecystectomy, Laparoscopic; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Middle Aged; Pain Measurement; Pain, Postoperative; Perioperative Care; Placebos; Prospective Studies; Thailand; Treatment Outcome | 2009 |
The effect of parecoxib on kidney function at laparoscopic hysterectomy.
Topics: Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Hysterectomy; Isoxazoles; Kidney; Laparoscopy; Middle Aged; Prospective Studies | 2009 |
Preemptive analgesia reduces pain after radical axillary lymph node dissection.
Topics: Adult; Aged; Analgesics; Axilla; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Fatigue; Female; Humans; Isoxazoles; Length of Stay; Lymph Node Excision; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Perioperative Care; Prospective Studies | 2010 |
Efficacy of subacromial ropivacaine infusion for rotator cuff surgery. A randomized trial.
Topics: Acromion; Adult; Amides; Analgesics, Opioid; Anesthetics, Local; Arthroscopy; Cyclooxygenase Inhibitors; Female; Humans; Infusion Pumps; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Minimally Invasive Surgical Procedures; Pain Measurement; Pain, Postoperative; Ropivacaine; Rotator Cuff; Single-Blind Method | 2009 |
Reduction in opioid-related adverse events and improvement in function with parecoxib followed by valdecoxib treatment after non-cardiac surgery: a randomized, double-blind, placebo-controlled, parallel-group trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Attitude of Health Personnel; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Elective Surgical Procedures; Female; Humans; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Patient Satisfaction; Placebos; Psychometrics; Sulfonamides | 2009 |
A randomised comparison of parecoxib versus placebo for pain management following minor day stay gynaecological surgery.
Topics: Adult; Cough; Cyclooxygenase 2 Inhibitors; Endpoint Determination; Female; Gynecologic Surgical Procedures; Humans; Isoxazoles; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Postoperative Complications; Postoperative Nausea and Vomiting; Postoperative Period; Young Adult | 2010 |
Effect of parecoxib pretreatment and venous occlusion on propofol injection pain: a prospective, randomized, double-blinded, placebo-controlled study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Pain; Pain Measurement; Propofol; Prospective Studies; Tourniquets; Treatment Outcome; Young Adult | 2010 |
Postoperative analgesia with parecoxib, acetaminophen, and the combination of both: a randomized, double-blind, placebo-controlled trial in patients undergoing thyroid surgery.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Humans; Isoxazoles; Middle Aged; Pain, Postoperative; Parathyroid Glands; Pirinitramide; Postoperative Care; Thyroid Gland; Young Adult | 2010 |
Preincisional versus postincisional administration of parecoxib in colorectal surgery: effect on postoperative pain control and cytokine response. A randomized clinical trial.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Colectomy; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Cytokines; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative | 2010 |
[Postoperative analgesic effect of parecoxib sodium in patients with posterior spinal surgery].
Topics: Analgesics, Non-Narcotic; Anesthesia, General; Cyclooxygenase 2 Inhibitors; Female; Humans; Injections, Intravenous; Isoxazoles; Male; Pain, Postoperative; Spinal Diseases | 2010 |
The post-operative analgesic efficacy of celecoxib compared with placebo and parecoxib after total hip or knee arthroplasty.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesia; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Celecoxib; Cyclooxygenase Inhibitors; Female; Humans; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Postoperative Period; Pyrazoles; Sulfonamides; Treatment Outcome; Young Adult | 2010 |
Analgesic effect of parecoxib and flurbiprofen axetil for patients undergoing laparoscopic cholecystectomy and their influences on platelet aggregation.
Topics: Analgesia; Cholecystectomy, Laparoscopic; Female; Flurbiprofen; Humans; Isoxazoles; Male; Platelet Aggregation | 2010 |
Intraoperative infusion of S(+)-ketamine enhances post-thoracotomy pain control compared with perioperative parecoxib when used in conjunction with thoracic paravertebral ropivacaine infusion.
Topics: Adult; Aged; Amides; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Injections, Spinal; Intraoperative Care; Isoxazoles; Ketamine; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Postoperative Care; Ropivacaine; Thoracotomy | 2011 |
Efficacy of intravenous paracetamol compared to dipyrone and parecoxib for postoperative pain management after minor-to-intermediate surgery: a randomised, double-blind trial.
Topics: Acetaminophen; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Dipyrone; Double-Blind Method; Female; Humans; Infusions, Intravenous; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Pirinitramide; Prospective Studies; Time Factors | 2011 |
Parecoxib sodium in the treatment of postoperative pain after Lichtenstein tension-free mesh inguinal hernia repair.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclofenac; Double-Blind Method; Female; Hernia, Inguinal; Humans; Isoxazoles; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Piroxicam; Prospective Studies; Surgical Procedures, Operative | 2011 |
[Effects of parecoxib sodium preemptive analgesia on perioperative cytokine responses and stress responses in patients undergoing ophthalmology surgery].
Topics: Adolescent; Adult; Analgesia; Female; Hormones; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-6; Interleukin-8; Intraoperative Period; Isoxazoles; Male; Middle Aged; Ophthalmologic Surgical Procedures; Premedication; Young Adult | 2010 |
[Preemptive analgesic effect of parecoxib sodium in patients undergoing laparoscopic colorectal surgery].
Topics: Adult; Analgesia; Analgesia, Patient-Controlled; Analgesics, Opioid; Butorphanol; Colorectal Surgery; Humans; Isoxazoles; Laparoscopy; Middle Aged | 2010 |
Comparison of the efficacy of parecoxib versus ketorolac combined with morphine on patient-controlled analgesia for post-cesarean delivery pain management.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Cesarean Section; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Infusions, Intravenous; Isoxazoles; Ketorolac; Morphine; Pain, Postoperative; Pregnancy | 2010 |
[Effects of parecoxib on morphine dosage in postoperative patient-controlled analgesia following thoracoscope-assisted thoracotomy].
Topics: Adult; Aged; Analgesia, Patient-Controlled; Combined Modality Therapy; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain, Postoperative; Thoracoscopy; Thoracotomy; Young Adult | 2011 |
Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans.
Topics: Adult; Analgesics, Opioid; Blood Pressure; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Humans; Hyperalgesia; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Remifentanil; Time Factors; Young Adult | 2011 |
Safety of parecoxib in asthmatic patients with aspirin-exacerbated respiratory disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma, Aspirin-Induced; Cyclooxygenase 2 Inhibitors; Female; Forced Expiratory Volume; Humans; Isoxazoles; Leukotriene E4; Male; Middle Aged; Nasal Provocation Tests | 2011 |
Effect of intravenous parecoxib on post-craniotomy pain.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Anti-Inflammatory Agents, Non-Steroidal; Craniotomy; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Morphine; Pain, Postoperative | 2011 |
Short stay and less pain after ambulatory anterior cruciate ligament (ACL) repair: COX-2 inhibitor versus glucocorticoid versus both combined.
Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Analysis of Variance; Anterior Cruciate Ligament Reconstruction; Blood Pressure; Cyclooxygenase 2 Inhibitors; Dexamethasone; Double-Blind Method; Drug Therapy, Combination; Endpoint Determination; Etoricoxib; Female; Glucocorticoids; Humans; Injections, Intravenous; Isoxazoles; Length of Stay; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Postoperative Nausea and Vomiting; Pyridines; Sample Size; Sulfones; Young Adult | 2012 |
Pharmacokinetics of intravenous and intramuscular parecoxib in healthy Beagles.
Topics: Acute Pain; Analgesia; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Dogs; Half-Life; Injections, Intramuscular; Injections, Intravenous; Isoxazoles; Male; Prodrugs; Sulfonamides | 2012 |
Pain control in laparoscopic gynecologic surgery with/without preoperative (preemptive) parecoxib sodium injection: a randomized study.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Gynecologic Surgical Procedures; Humans; Injections, Intravenous; Isoxazoles; Laparoscopy; Meperidine; Middle Aged; Pain Measurement; Pain, Postoperative; Perioperative Care; Prospective Studies; Thailand; Treatment Outcome; Young Adult | 2011 |
Non-steroidal anti-inflammatory drugs reduce the stress response during sevoflurane anesthesia.
Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cyclooxygenase 2 Inhibitors; Female; Flurbiprofen; Heart Rate; Humans; Infusions, Intravenous; Intraoperative Complications; Isoxazoles; Lidocaine; Male; Methyl Ethers; Middle Aged; Prospective Studies; Pulmonary Alveoli; Sevoflurane; Skin; Sodium Channel Blockers; Young Adult | 2012 |
Prevention of pain on injection of rocuronium: a comparison of lidocaine with different doses of parecoxib.
Topics: Academic Medical Centers; Adult; Androstanols; Anesthetics, Local; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections; Isoxazoles; Lidocaine; Male; Middle Aged; Neuromuscular Nondepolarizing Agents; Pain; Pain Measurement; Prospective Studies; Rocuronium; Severity of Illness Index | 2012 |
A randomized, double-blind, controlled trial on non-opioid analgesics and opioid consumption for postoperative pain relief after laparoscopic cholecystectomy.
Topics: Acetaminophen; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cholecystectomy, Laparoscopic; Dipyrone; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Pirinitramide; Treatment Outcome | 2012 |
The efficacy of parecoxib on systemic inflammatory response associated with cardiopulmonary bypass during cardiac surgery.
Topics: Adult; Biomarkers; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Creatine Kinase; Creatine Kinase, MB Form; Cyclooxygenase 2 Inhibitors; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Heart Valve Prosthesis Implantation; Humans; Inflammation; Isoxazoles; Leukocyte Count; Male; Middle Aged; Mitral Valve; Postoperative Complications; Treatment Outcome; Troponin T | 2013 |
Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy.
Topics: Adult; Analgesics; Drug Administration Schedule; Female; Gynecologic Surgical Procedures; Humans; Isoxazoles; Laparoscopy; Pain Measurement; Pain, Postoperative; Shoulder Pain; Treatment Outcome | 2012 |
Parecoxib added to ropivacaine prolongs duration of axillary brachial plexus blockade and relieves postoperative pain.
Topics: Adolescent; Adult; Aged; Amides; Anesthetics, Local; Brachial Plexus; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Male; Middle Aged; Nerve Block; Pain Measurement; Pain, Postoperative; Ropivacaine | 2013 |
Comparison of preincisional and postincisional parecoxib administration on postoperative pain control and cytokine response after total hip replacement.
Topics: Aged; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Cyclooxygenase 2 Inhibitors; Cytokines; Female; Femur Head Necrosis; Hip Fractures; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative | 2012 |
Efficacy of three IV non-opioid-analgesics on opioid consumption for postoperative pain relief after total thyroidectomy: a randomised, double-blind trial.
Topics: Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Dipyrone; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Isoxazoles; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Pirinitramide; Thyroidectomy; Time Factors | 2012 |
Effect of perioperative parecoxib on postoperative pain and local inflammation factors PGE2 and IL-6 for total knee arthroplasty: a randomized, double-blind, placebo-controlled study.
Topics: Aged; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Cyclooxygenase 2 Inhibitors; Dinoprostone; Double-Blind Method; Female; Humans; Inflammation; Interleukin-6; Isoxazoles; Knee Joint; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Postoperative Nausea and Vomiting; Range of Motion, Articular; Synovial Fluid | 2014 |
Effects of parecoxib on morphine analgesia after gynecology tumor operation: a randomized trial of parecoxib used in postsurgical pain management.
Topics: Adult; Analgesics, Opioid; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Genital Neoplasms, Female; Humans; Isoxazoles; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Treatment Outcome | 2013 |
Application of parecoxib in post-uvulopalatopharyngoplasty analgesia.
Topics: Adult; Amides; Anesthesia, Local; Anesthetics, Local; Cyclooxygenase 2 Inhibitors; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Pain Management; Pain Measurement; Pain, Postoperative; Palate, Soft; Ropivacaine; Sleep Apnea, Obstructive | 2013 |
Effect of parecoxib sodium on postoperative shivering: a randomised, double-blind clinical trial.
Topics: Adult; Anesthesia, General; Double-Blind Method; Female; Follow-Up Studies; Humans; Incidence; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Postoperative Complications; Postoperative Nausea and Vomiting; Prospective Studies; Severity of Illness Index; Shivering; Tramadol; Young Adult | 2014 |
[Effects of parecoxib sodium analgesia on serum concentrations of neuron-specific enolase and S-100β and postoperative cognitive function of elderly patients undergoing acute replacement of femoral head].
Topics: Aged; Aged, 80 and over; Analgesia; Arthroplasty, Replacement, Hip; Female; Hip Prosthesis; Humans; Isoxazoles; Male; Pain Management; Phosphopyruvate Hydratase; Postoperative Period; S100 Calcium Binding Protein beta Subunit | 2013 |
[Combined efficacy of parecoxib and incisional ropivacaine infiltration on pain management after diagnostic hysteroscopy and laparoscopy].
Topics: Adolescent; Adult; Amides; Anesthetics, Local; Female; Humans; Hysteroscopy; Isoxazoles; Laparoscopy; Middle Aged; Pain Measurement; Pain, Postoperative; Ropivacaine; Shoulder Pain; Young Adult | 2013 |
[Effect analysis of multimode analgesia of parecoxib sodium during laparoscopic cholecystectomy].
Topics: Adult; Aged; Analgesia; Cholecystectomy, Laparoscopic; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Pain Management; Pain, Postoperative; Prospective Studies | 2013 |
A randomised controlled trial of parecoxib, celecoxib and paracetamol as adjuncts to patient-controlled epidural analgesia after caesarean delivery.
Topics: Acetaminophen; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Celecoxib; Cesarean Section; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Pregnancy; Pyrazoles; Sulfonamides | 2014 |
Parecoxib and paracetamol for pain relief following minor day-stay gynaecological surgery.
Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Gynecologic Surgical Procedures; Humans; Isoxazoles; Middle Aged; Pain, Postoperative | 2014 |
Preoperative intravenous parecoxib reduces length of stay on ambulatory laparoscopic cholecystectomy.
Topics: Administration, Intravenous; Adult; Ambulatory Surgical Procedures; Cholecystectomy, Laparoscopic; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Length of Stay; Male; Middle Aged; Pain, Postoperative; Patient Discharge; Preoperative Care; Prospective Studies | 2014 |
The pharmacokinetics and in vitro/ex vivo cyclooxygenase selectivity of parecoxib and its active metabolite valdecoxib in cats.
Topics: Animals; Area Under Curve; Cats; Cyclooxygenase Inhibitors; Isoxazoles; Male; Sulfonamides | 2014 |
Comparison of the analgesic effects of cryoanalgesia vs. parecoxib for lung cancer patients after lobectomy.
Topics: Adult; Aged; Analgesia; Cryoanesthesia; Female; Humans; Intercostal Nerves; Isoxazoles; Lung Neoplasms; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Pneumonectomy | 2015 |
Multi-dose parecoxib provides an immunoprotective effect by balancing T helper 1 (Th1), Th2, Th17 and regulatory T cytokines following laparoscopy in patients with cervical cancer.
Topics: Adult; Aged; Analgesics; Cytokines; Female; Hospitalization; Humans; Isoxazoles; Laparoscopy; Middle Aged; Neoplasm Staging; Pain Measurement; Pain, Postoperative; RNA, Messenger; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Th2 Cells; Uterine Cervical Neoplasms | 2015 |
Efficacy and safety of parecoxib/phloroglucinol combination therapy versus parecoxib monotherapy for acute renal colic: a randomized, double-blind clinical trial.
Topics: Adolescent; Adult; Aged; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Pain Measurement; Parasympatholytics; Phloroglucinol; Renal Colic; Treatment Outcome | 2014 |
Single bolus parecoxib attenuates sore throat after laryngeal microsurgery: a randomized double-blind control study.
Topics: Adult; Female; Humans; Isoxazoles; Larynx; Male; Microsurgery; Middle Aged; Morphine; Patient Satisfaction; Pharyngitis; Postoperative Complications | 2014 |
[Study on the preemptive analgesia effects of both the parecoxib sodium and the pentazocine in patients undergoing nasal endoscopic surgery].
Topics: Analgesia; Analgesics; Double-Blind Method; Endoscopy; Humans; Isoxazoles; Nasal Surgical Procedures; Nose; Pain; Pain, Postoperative; Pentazocine | 2014 |
Effects of parecoxib on analgesia benefit and blood loss following open prostatectomy: a multicentre randomized trial.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Therapy, Combination; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Postoperative Hemorrhage; Prostatectomy | 2015 |
Safety and Efficacy Study of the Cyclooxygenase-2 Inhibitor Parecoxib Sodium Applied for Postoperative Analgesia After Endo-Nasal Operation.
Topics: Adolescent; Adult; Cyclooxygenase 2 Inhibitors; Endoscopy; Female; Humans; Isoxazoles; Male; Middle Aged; Otorhinolaryngologic Surgical Procedures; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Young Adult | 2016 |
Comparing parecoxib and ketorolac as preemptive analgesia in patients undergoing posterior lumbar spinal fusion: a prospective randomized double-blinded placebo-controlled trial.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dyspepsia; Female; Humans; Incidence; Injections, Intravenous; Isoxazoles; Ketorolac; Lumbar Vertebrae; Male; Middle Aged; Nausea; Pain, Postoperative; Prospective Studies; Spinal Fusion; Treatment Outcome | 2015 |
Parecoxib for the prevention of shivering after general anesthesia.
Topics: Adult; Anesthesia, General; Body Temperature; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Shivering; Treatment Outcome | 2015 |
Effects of preemptive analgesia with parecoxib sodium on haemodynamics and plasma stress hormones in surgical patients with thyroid carcinoma.
Topics: Adult; Aged; Analgesia; Blood Glucose; Case-Control Studies; Cyclooxygenase 2 Inhibitors; Female; Follow-Up Studies; Hemodynamics; Humans; Hydrocortisone; Isoxazoles; Male; Middle Aged; Neoplasm Staging; Norepinephrine; Prognosis; Thyroid Neoplasms; Thyroidectomy | 2015 |
Effect of cyclooxygenase-2-specific inhibitors on postoperative analgesia after major open abdominal surgery.
Topics: Abdomen; Analgesia, Patient-Controlled; Analgesics, Opioid; Analysis of Variance; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Prospective Studies; Tramadol | 2015 |
Analgesic Effects of Intra-Articular Bupivacaine/Intravenous Parecoxib Combination Therapy versus Intravenous Parecoxib Monotherapy in Patients Receiving Total Knee Arthroplasty: A Randomized, Double-Blind Trial.
Topics: Adult; Aged; Analgesics; Arthroplasty, Replacement, Knee; Bupivacaine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Intra-Articular; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Pain, Postoperative | 2015 |
Postoperative Pain Relief in Major Gynaecological Surgery by Perioperative Parecoxib Administration: Thammasat University Hospital Study.
Topics: Adult; Aged; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Gynecologic Surgical Procedures; Hospitals, University; Humans; Injections, Intravenous; Isoxazoles; Meperidine; Middle Aged; Pain Measurement; Pain, Postoperative; Prospective Studies | 2015 |
[Comparison of the effects of different analgesic methods after UPPP].
Topics: Analgesia; Analgesics; Humans; Injections, Intramuscular; Isoxazoles; Pain Measurement; Pain, Postoperative; Palate; Pharynx; Tramadol; Uvula | 2015 |
[The effect of parecoxib sodium for preemptive analgesia on nasal endoscopic surgery].
Topics: Analgesia; Double-Blind Method; Endoscopy; Humans; Isoxazoles; Nasal Surgical Procedures; Pain, Postoperative | 2015 |
Parecoxib sodium reduces the need for opioids after tonsillectomy in children: a double-blind placebo-controlled randomized clinical trial.
Topics: Analgesics, Opioid; Child; Child, Preschool; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Male; Pain, Postoperative; Postoperative Nausea and Vomiting; Prospective Studies; Tonsillectomy | 2016 |
Effect of perioperative parecoxib sodium on postoperative pain control for transcatheter arterial chemoembolization for inoperable hepatocellular carcinoma: a prospective randomized trial.
Topics: Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Liver Neoplasms; Male; Middle Aged; Pain, Postoperative; Perioperative Care; Prospective Studies; Treatment Outcome | 2016 |
Propranolol Attenuates Surgical Stress-Induced Elevation of the Regulatory T Cell Response in Patients Undergoing Radical Mastectomy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Breast Neoplasms; Catecholamines; Cell Proliferation; Cells, Cultured; Dinoprostone; Epinephrine; Female; Forkhead Transcription Factors; Humans; Immune Tolerance; Inflammation; Interferon-gamma; Isoxazoles; Leukocytes, Mononuclear; Lymphocyte Count; Mastectomy, Radical; Middle Aged; Norepinephrine; Propranolol; RNA, Messenger; Stress, Physiological; T-Lymphocytes, Regulatory | 2016 |
Effects of Pre-Existing Liver Disease on Acute Pain Management Using Patient-Controlled Analgesia Fentanyl With Parecoxib After Major Liver Resection: A Retrospective, Pragmatic Study.
Topics: Acute Pain; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Drug Therapy, Combination; Female; Fentanyl; Hepatectomy; Humans; Isoxazoles; Liver Cirrhosis; Liver Transplantation; Living Donors; Male; Middle Aged; Pain Management; Pain Measurement; Pain, Postoperative; Retrospective Studies | 2016 |
Parecoxib prevents early postoperative cognitive dysfunction in elderly patients undergoing total knee arthroplasty: A double-blind, randomized clinical consort study.
Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Knee; Biomarkers; Cognitive Dysfunction; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Male; Neuropsychological Tests; Pain, Postoperative | 2016 |
Efficacy and safety of Postoperative Intravenous Parecoxib sodium Followed by ORal CElecoxib (PIPFORCE) post-total knee arthroplasty in patients with osteoarthritis: a study protocol for a multicentre, double-blind, parallel-group trial.
Topics: Administration, Oral; Arthroplasty, Replacement, Knee; Celecoxib; China; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Therapy, Combination; Humans; Injections, Intravenous; Isoxazoles; Osteoarthritis; Pain, Postoperative; Postoperative Care; Research Design; Treatment Outcome | 2016 |
Effect of Parecoxib as an Adjunct to Patient-Controlled Epidural Analgesia after Abdominal Hysterectomy: A Multicenter, Randomized, Placebo-Controlled Trial.
Topics: Adolescent; Adult; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Hysterectomy; Isoxazoles; Middle Aged; Morphine; Pain Management; Pain, Postoperative; Ropivacaine; Young Adult | 2016 |
Parecoxib, propacetamol, and their combination for analgesia after total hip arthroplasty: a randomized non-inferiority trial.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Arthroplasty, Replacement, Hip; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Recovery of Function | 2017 |
Efficacy of a single 40-mg intravenous dose of parecoxib for postoperative pain control after elective cesarean delivery: A double-blind randomized placebo-controlled trial.
Topics: Administration, Intravenous; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cesarean Section; Double-Blind Method; Female; Humans; Isoxazoles; Meperidine; Pain, Postoperative; Pregnancy | 2017 |
Hyperalgesia and Persistent Pain after Breast Cancer Surgery: A Prospective Randomized Controlled Trial with Perioperative COX-2 Inhibition.
Topics: Adult; Aged; Breast Neoplasms; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Hyperalgesia; Isoxazoles; Mastectomy; Mastectomy, Segmental; Middle Aged; Pain Measurement; Pain Threshold; Pain, Postoperative; Perioperative Period; Prospective Studies; Quality of Life; Surveys and Questionnaires; Treatment Outcome | 2016 |
Parecoxib sodium pretreatment reduces myoclonus after etomidate: A prospective, double-blind, randomized clinical trial
.
Topics: Administration, Intravenous; Adult; Anesthesia, General; Anesthetics, Intravenous; China; Cholecystectomy, Laparoscopic; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Administration Schedule; Elective Surgical Procedures; Etomidate; Female; Humans; Isoxazoles; Male; Middle Aged; Myoclonus; Prospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult | 2017 |
Application of a buprenorphine transdermal patch for the perioperative analgesia in patients who underwent simple lumbar discectomy.
Topics: Administration, Cutaneous; Administration, Intravenous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Celecoxib; Cyclooxygenase 2 Inhibitors; Diskectomy; Female; Humans; Isoxazoles; Lumbar Vertebrae; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Perioperative Care; Tramadol; Transdermal Patch; Treatment Outcome | 2017 |
Parecoxib Supplementation to Morphine Analgesia Decreases Incidence of Delirium in Elderly Patients After Hip or Knee Replacement Surgery: A Randomized Controlled Trial.
Topics: Administration, Intravenous; Age Factors; Aged; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; China; Cyclooxygenase 2 Inhibitors; Delirium; Double-Blind Method; Female; Humans; Incidence; Intention to Treat Analysis; Isoxazoles; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Risk Factors; Severity of Illness Index; Time Factors; Treatment Outcome | 2017 |
Effect of parecoxib sodium pretreatment combined with dexmedetomidine on early postoperative cognitive dysfunction in elderly patients after shoulder arthroscopy: A randomized double blinded controlled trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroscopy; Bradycardia; Brain; Cerebrovascular Circulation; Cognitive Dysfunction; Cyclooxygenase 2 Inhibitors; Dexmedetomidine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Humans; Incidence; Isoxazoles; Middle Aged; Oxygen; Pain, Postoperative; Partial Pressure; Perioperative Period; Postoperative Nausea and Vomiting; Respiratory Insufficiency; Shoulder; Sufentanil; Treatment Outcome | 2017 |
[Phloroglucinol combined with parecoxib for cystospasm after transurethral resection of the prostate].
Topics: Aged; Case-Control Studies; Drug Therapy, Combination; Humans; Isoxazoles; Length of Stay; Male; Middle Aged; Phloroglucinol; Postoperative Period; Prospective Studies; Prostatic Hyperplasia; Spasm; Therapeutic Irrigation; Transurethral Resection of Prostate; Treatment Outcome; Urinary Bladder | 2016 |
[Parecoxib suppresses the increase of neutrophil-to-lymphocyte ratio after the modified radical mastectomy].
Topics: Breast Neoplasms; Cyclooxygenase 2 Inhibitors; Female; Humans; Inflammation; Isoxazoles; Lymphocytes; Mastectomy; Neutrophils; Treatment Outcome | 2017 |
Analgesic effect of different dosage of Flurbiprofen axetil in laparoscopic cholecystectomy in comparison with other analgesic drugs.
Topics: Administration, Intravenous; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cholecystectomy, Laparoscopic; Dose-Response Relationship, Drug; Female; Flurbiprofen; Humans; Isoxazoles; Male; Middle Aged; Pain Measurement; Young Adult | 2017 |
The Effectiveness of Intravenous Parecoxib on the Incidence of Ipsilateral Shoulder Pain After Thoracotomy: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Administration, Intravenous; Adult; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Follow-Up Studies; Humans; Incidence; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Shoulder Pain; Thoracotomy; Treatment Outcome | 2018 |
[EFFICACY OF SEQUENTIAL TREATMENT WITH ADDUCTOR CANAL NERVE BLOCK AND CYCLOOXYGENASE 2 SELECTIVE INHIBITOR AFTER TOTAL KNEE ARTHROPLASTY].
Topics: Analgesics, Opioid; Arthroplasty, Replacement, Knee; Celecoxib; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Knee Joint; Morphine; Nerve Block; Operative Time; Osteoarthritis; Pain, Postoperative; Postoperative Period; Range of Motion, Articular; Treatment Outcome | 2016 |
Parenteral Parecoxib Provides a Similar Reduction in Opioid Requirement to Single-Shot Sciatic Nerve Block after Total Knee Arthroplasty when Combined with Continuous Femoral Nerve Block.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Cyclooxygenase 2 Inhibitors; Female; Humans; Infusions, Parenteral; Isoxazoles; Male; Middle Aged; Nerve Block; Pain, Postoperative; Patient Satisfaction; Sciatic Nerve | 2017 |
Preemptive Analgesia with Parecoxib in Total Hip Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Analgesics; Arthroplasty, Replacement, Hip; China; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Pain, Postoperative | 2018 |
Evaluation of Intravenous Parecoxib Infusion Pump of Patient-Controlled Analgesia Compared to Fentanyl for Postoperative Pain Management in Laparoscopic Liver Resection.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; Female; Fentanyl; Hepatectomy; Humans; Infusion Pumps; Infusions, Intravenous; Isoxazoles; Laparoscopy; Liver; Male; Middle Aged; Pain Management; Pain, Postoperative; Prospective Studies | 2018 |
Role of Parecoxib Sodium in the Multimodal Analgesia after Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Isoxazoles; Knee Joint; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Range of Motion, Articular | 2018 |
Effect of preintravenous injection of parecoxib, combined with transversus abdominis plane block in strategy of enhanced recovery after radical resection of colorectal cancer.
Topics: Adolescent; Adult; Aged; Colorectal Neoplasms; Combined Modality Therapy; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Pain Measurement; Pain, Postoperative; Tomography, X-Ray Computed; Treatment Outcome; Young Adult | 2018 |
Effectiveness of Parecoxib Sodium Combined with Transversus Abdominis Plane Block for Pain Management After Hepatectomy for Hepatocellular Carcinoma: A Prospective Controlled Study.
Topics: Abdominal Muscles; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Carcinoma, Hepatocellular; China; Female; Hepatectomy; Humans; Isoxazoles; Liver Neoplasms; Male; Middle Aged; Nerve Block; Pain Management; Pain Measurement; Pain, Postoperative; Postoperative Complications; Prospective Studies; Ropivacaine | 2019 |
Efficacy and Safety of COX-2 Inhibitor Parecoxib for Rigid Cystoscopy-related Pain Management in Male Patients: A Prospective, Randomized and Controlled Study.
Topics: Ambulatory Care Facilities; Cyclooxygenase 2 Inhibitors; Cystoscopy; Double-Blind Method; Humans; Injections, Intramuscular; Isoxazoles; Male; Middle Aged; Pain; Pain Management; Pain Measurement; Prospective Studies; Tetracaine; Treatment Outcome | 2019 |
[Efficacy of local infiltration of ropivacaine combined with multimodal analgesia with parecoxib for perioperative analgesia in patients undergoing pancreaticoduodenectomy].
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; China; Double-Blind Method; Humans; Isoxazoles; Pain Management; Pain Measurement; Pain, Postoperative; Pancreaticoduodenectomy; Ropivacaine | 2019 |
Perioperative analgesia with parecoxib sodium improves postoperative pain and immune function in patients undergoing hepatectomy for hepatocellular carcinoma.
Topics: Analgesics, Opioid; Carcinoma, Hepatocellular; Hepatectomy; Humans; Immunity; Isoxazoles; Liver Neoplasms; Pain, Postoperative | 2020 |
Pain Management Using Perioperative Administration of Parecoxib for Total Hip Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Prospective Studies | 2019 |
Protective efficacy of combined use of parecoxib and dexmedetomidine on postoperative hyperalgesia and early cognitive dysfunction after laparoscopic cholecystectomy for elderly patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Aged, 80 and over; Analysis of Variance; Arterial Pressure; Cholecystectomy, Laparoscopic; Cyclooxygenase 2 Inhibitors; Dexmedetomidine; Drug Therapy, Combination; Female; Heart Rate; Humans; Isoxazoles; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Postoperative Cognitive Complications; Prospective Studies; Time Factors; Treatment Outcome | 2019 |
Postoperative intravenous parecoxib sodium followed by oral celecoxib post total knee arthroplasty in osteoarthritis patients (PIPFORCE): a multicentre, double-blind, randomised, placebo-controlled trial.
Topics: Administration, Intravenous; Administration, Oral; Aged; Arthroplasty, Replacement, Knee; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Osteoarthritis, Knee; Pain, Postoperative; Postoperative Care; Retrospective Studies; Treatment Outcome | 2020 |
Combination of Epidural Blockade and Parecoxib in Enhanced Recovery After Gastrointestinal Surgery.
Topics: Digestive System Surgical Procedures; Humans; Isoxazoles; Pain Measurement; Pain, Postoperative; Prospective Studies | 2021 |
Prevention of Severe Acute Pancreatitis With Cyclooxygenase-2 Inhibitors: A Randomized Controlled Clinical Trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Pancreatitis; Prospective Studies; Severity of Illness Index; Treatment Outcome; Young Adult | 2020 |
Parecoxib in laparoscopic surgery for simple vesicular lithiasis.
Topics: Adult; Analgesia; Analgesics, Opioid; Cholecystectomy, Laparoscopic; Combined Modality Therapy; Double-Blind Method; Female; Humans; Isoxazoles; Lithiasis; Male; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Recovery Room; Tunisia; Urinary Bladder Calculi | 2019 |
The relationship between postoperative opioid consumption and the incidence of hypoxemic events following total hip arthroplasty: a post hoc analysis.
Topics: Acetaminophen; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Hypoxia; Incidence; Isoxazoles; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Switzerland; Treatment Outcome | 2020 |
The clinical effect of dexmedetomidine combined with parecoxib sodium on sedation, antianxiety and prevention of intubation stress in patients undergoing functional endoscopic sinus surgery: a randomised controlled trial.
Topics: Adult; Anxiety; Conscious Sedation; Dexmedetomidine; Endoscopy; Female; Humans; Intubation, Intratracheal; Isoxazoles; Male; Middle Aged; Paranasal Sinuses; Stress, Psychological | 2020 |
Comparison of analgesic efficacy of acetaminophen monotherapy versus acetaminophen combinations with either pethidine or parecoxib in patients undergoing laparoscopic cholecystectomy: a randomized prospective study.
Topics: Acetaminophen; Analgesics; Cholecystectomy, Laparoscopic; Double-Blind Method; Humans; Isoxazoles; Meperidine; Pain Measurement; Pain, Postoperative; Prospective Studies | 2021 |
A randomized controlled trial comparing the efficacies of ketorolac and parecoxib for early pain management after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Knee; Blood Transfusion; Bupivacaine; Drug Therapy, Combination; Drug Utilization; Female; Humans; Injections, Intra-Articular; Isoxazoles; Ketorolac; Male; Middle Aged; Morphine; Pain, Postoperative; Prospective Studies; Visual Analog Scale | 2020 |
Parecoxib Vs Paracetamol for Treatment of Acute Renal Colic Due to Ureteric Calculi: A Randomized Controlled Trial.
Topics: Acetaminophen; Adult; Emergency Service, Hospital; Female; Humans; Infusions, Intravenous; Isoxazoles; Male; Middle Aged; Pain Management; Pain Measurement; Renal Colic; Treatment Outcome; Ureteral Calculi | 2021 |
Intraoperative periarticular injection can alleviate the inflammatory response and enhance joint function recovery after hip arthroplasty in elderly patients with osteoporotic femoral neck fractures.
Topics: Aged; Arthroplasty, Replacement, Hip; Betamethasone; Biomarkers; Drug Therapy, Combination; Epinephrine; Female; Femoral Neck Fractures; Humans; Inflammation Mediators; Injections, Intra-Articular; Intraoperative Care; Isoxazoles; Male; Morphine; Osteoporotic Fractures; Postoperative Complications; Recovery of Function; Ropivacaine | 2021 |
An opioid-sparing protocol with intravenous parecoxib can effectively reduce morphine consumption after simultaneous bilateral total knee arthroplasty.
Topics: Administration, Intravenous; Aged; Arthroplasty, Replacement, Knee; Female; Humans; Isoxazoles; Knee Joint; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Physical Therapy Modalities; Postoperative Period; Prospective Studies; Range of Motion, Articular; Treatment Outcome; Visual Analog Scale | 2021 |
Effects of parecoxib after pancreaticoduodenectomy: A single center randomized controlled trial.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Pancreaticoduodenectomy | 2021 |
Effect of perioperative use of parecoxib on chronic post-surgical pain in elderly patients after hepatectomy: a prospective randomized controlled study.
Topics: Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Hepatectomy; Humans; Isoxazoles; Male; Pain Measurement; Pain, Postoperative; Perioperative Care | 2021 |
Effects of bilateral Pecto-intercostal Fascial Block for perioperative pain management in patients undergoing open cardiac surgery: a prospective randomized study.
Topics: Adult; Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Hospitalization; Humans; Insulin Resistance; Intensive Care Units; Isoxazoles; Length of Stay; Male; Middle Aged; Nerve Block; Pain Measurement; Pain, Postoperative; Prospective Studies; Sufentanil; Ultrasonography, Interventional | 2021 |
Efficacy of intravenous perioperative parecoxib administration in the surgical fixation of unstable ankle fracture: a prospective, double-blinded, randomized, placebo-controlled trial.
Topics: Ankle Fractures; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Prospective Studies | 2021 |
Effect and Safety of Prophylactic Parecoxib for Pain Control of Transarterial Chemoembolization in Liver Cancer: A Single-Center, Parallel-Group, Randomized Trial.
Topics: Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Humans; Isoxazoles; Liver Neoplasms; Pain, Postoperative; Prospective Studies | 2022 |
Comparison of Combination Between Ketamine and Parecoxib as Multimodal Preemptive Analgesia With Ketamine Alone for Elective Laparotomy.
Topics: Analgesia, Patient-Controlled; Humans; Isoxazoles; Ketamine; Laparotomy; Pain, Postoperative; Prospective Studies | 2021 |
198 other study(ies) available for parecoxib and isoxazoles
| Article | Year |
|---|---|
N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.
Topics: Acylation; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dogs; Injections; Isoenzymes; Isoxazoles; Macaca fascicularis; Male; Prostaglandin-Endoperoxide Synthases; Rats | 2000 |
Parecoxib (parecoxib sodium).
Topics: Abdominal Pain; Cyclooxygenase Inhibitors; Dizziness; Headache; Humans; Infusions, Intravenous; Injections, Intramuscular; Isoxazoles; Nausea; Pain; Randomized Controlled Trials as Topic | 2001 |
The injectable cyclooxygenase-2-specific inhibitor parecoxib sodium has analgesic efficacy when administered preoperatively.
Topics: Adolescent; Adult; Analgesics; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Molar, Third; Oral Surgical Procedures; Pain; Pain Measurement; Pain, Postoperative; Preoperative Care; Prostaglandin-Endoperoxide Synthases; Tooth Extraction | 2001 |
[Control of postoperative pain. First COX-2 inhibitor for injection].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Injections, Intramuscular; Injections, Intravenous; Isoxazoles; Pain, Postoperative; Prodrugs | 2002 |
Concluding remarks. C0X-2-selective inhibition: a new advance in pain management.
Topics: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain; Premedication; Prostaglandin-Endoperoxide Synthases | 2002 |
Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Bony Callus; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fracture Healing; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Torsion Abnormality | 2003 |
Effects of rofecoxib, celecoxib, and parecoxib on anti-IgE-induced histamine release from human skin mast cells and basophils.
Topics: Antibodies, Anti-Idiotypic; Basophils; Celecoxib; Cyclooxygenase Inhibitors; Histamine Release; Humans; Isoxazoles; Lactones; Mast Cells; Pyrazoles; Skin; Sulfonamides; Sulfones | 2003 |
Stability of reconstituted parecoxib for injection with commonly used diluents.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Stability; Drug Storage; Injections; Isoxazoles | 2003 |
Efficacy and safety of the first parenteral selective COX-2 inhibitor, parecoxib sodium, in adult patients with postoperative pain.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Cyclooxygenase 2; Female; Humans; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Pain, Postoperative; Postoperative Care; Prostaglandin-Endoperoxide Synthases; Treatment Outcome | 2003 |
Reporting of clinical trials of analgesia.
Topics: Analgesia; Analgesia, Patient-Controlled; Clinical Trials as Topic; Coronary Artery Bypass; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Morphine; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2004 |
Effect of selective inhibition of cyclooxygenase-2 on lipopolysaccharide-induced hyperalgesia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Hyperalgesia; Isoenzymes; Isoxazoles; Lipopolysaccharides; Male; Mice; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar | 2004 |
Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fracture Healing; Isoenzymes; Isoxazoles; Ketorolac; Prostaglandin-Endoperoxide Synthases; Rats | 2004 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Endotoxins; Female; Fever; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Mice; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach | 2004 |
Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms.
Topics: Animals; Brain; Diclofenac; Enzyme Inhibitors; Indomethacin; Isoxazoles; Kynurenic Acid; Male; Meloxicam; Prostaglandins; Protein Isoforms; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles | 2005 |
Reaction between parecoxib and vecuronium.
Topics: Chemical Precipitation; Cyclooxygenase Inhibitors; Drug Interactions; Female; Humans; Isoxazoles; Neuromuscular Nondepolarizing Agents; Vecuronium Bromide | 2004 |
Selective cyclooxygenase-2 inhibition reverses microcirculatory and inflammatory sequelae of closed soft-tissue trauma in an animal model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cyclooxygenase Inhibitors; Hindlimb; Immunohistochemistry; Isoxazoles; Male; Microcirculation; Microscopy, Fluorescence; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Soft Tissue Injuries | 2005 |
Parecoxib, valdecoxib, and cardiovascular risk.
Topics: Cardiovascular Diseases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Membrane Proteins; Meta-Analysis as Topic; Prodrugs; Product Surveillance, Postmarketing; Prostaglandin-Endoperoxide Synthases; Randomized Controlled Trials as Topic; Risk Assessment; Sulfonamides | 2005 |
[Review of analgesics].
Topics: Analgesics; Delayed-Action Preparations; Drug and Narcotic Control; Drug Prescriptions; Drug Therapy; France; Humans; Isoxazoles; Oxycodone; Pain; Patient Selection; Tramadol | 2004 |
Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Genes, ras; Image Processing, Computer-Assisted; Immunohistochemistry; Isoxazoles; Ki-67 Antigen; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Microcirculation; Mutation; Neoplasm Metastasis; Neoplasm Transplantation; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins p21(ras); RNA Interference; Time Factors | 2005 |
Severe bronchospasm after parenteral parecoxib: cyclooxygenase-2 inhibitors: not the answer yet.
Topics: Acute Disease; Adult; Aged; Bronchial Spasm; Cyclooxygenase Inhibitors; Female; Humans; Infusions, Intravenous; Injections, Intramuscular; Isoxazoles; Male | 2005 |
Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Disease Models, Animal; Female; Hyperalgesia; Isoenzymes; Isoxazoles; Ketorolac; Lipopolysaccharides; Male; Mice; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Salmonella typhimurium | 2005 |
COX-2 inhibitors--lessons in drug safety.
Topics: Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Approval; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Publishing; Pyrazoles; Randomized Controlled Trials as Topic; Research Design; Sulfonamides; Sulfones; United States; United States Food and Drug Administration | 2005 |
COX-2 inhibitors--a lesson in unexpected problems.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Approval; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones | 2005 |
Parecoxib versus ibuprofen.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Ibuprofen; Injections, Intramuscular; Isoxazoles; Ketorolac; Pain, Postoperative; Tooth Extraction | 2005 |
Changing role of COX-2 inhibitors in the perioperative period: is parecoxib really the answer?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Pain, Postoperative | 2005 |
Combination therapy using the cyclooxygenase-2 inhibitor Parecoxib and radioimmunotherapy in nude mice with small peritoneal metastases of colonic origin.
Topics: Animals; Antibodies, Monoclonal; Carcinoma; Colonic Neoplasms; Cyclooxygenase Inhibitors; Iodine Radioisotopes; Isoxazoles; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Nude; Peritoneal Neoplasms; Radioimmunotherapy; Survival; Tissue Distribution; Transplantation, Heterologous | 2006 |
The antinociceptive effect of local or systemic parecoxib combined with lidocaine/clonidine intravenous regional analgesia for complex regional pain syndrome type I in the arm.
Topics: Adrenergic alpha-Agonists; Aged; Analgesics; Anesthetics, Local; Arm; Clonidine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Female; Humans; Isoxazoles; Lidocaine; Male; Membrane Proteins; Middle Aged; Outpatients; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Reflex Sympathetic Dystrophy | 2005 |
Effects of intrarenal administration of the cox-2 inhibitor parecoxib during porcine suprarenal aortic cross-clamping.
Topics: Angiography; Animals; Aorta; Aortic Aneurysm, Abdominal; Arachidonic Acid; Creatinine; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Hemodynamics; Isoxazoles; Kidney; Male; Prospective Studies; Regional Blood Flow; Renal Circulation; Reperfusion Injury; Swine; Time Factors | 2005 |
[Use of low molecular weight heparin (Clexane) together with selective COX-2 inhibitor (Dynastat--once or twice per day)].
Topics: Anticoagulants; Cyclooxygenase Inhibitors; Drug Administration Schedule; Drug Therapy, Combination; Enoxaparin; Female; Follow-Up Studies; Heparin, Low-Molecular-Weight; Humans; Hysterectomy; Isoxazoles; Laparoscopy; Postoperative Complications; Treatment Outcome | 2005 |
Effects of COX-1 and COX-2 inhibitors on the firing of rat midbrain dopaminergic neurons--possible involvement of endogenous kynurenic acid.
Topics: Action Potentials; Animals; Chromatography, High Pressure Liquid; Dopamine; Drug Interactions; Electrochemistry; Enzyme Inhibitors; Indomethacin; Isoxazoles; Kynurenic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Ventral Tegmental Area | 2006 |
Safety of cox-2 selective nonsteroidal antiinflammatory drugs for postsurgical pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Pain, Postoperative | 2006 |
Laryngospasm and bronchospasm following parecoxib injections.
Topics: Bronchial Spasm; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Laryngismus; Pain, Postoperative | 2005 |
Postsurgical safety of opioid-sparing cyclooxygenase-2 inhibitors.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Lactones; Pain, Postoperative; Sulfones | 2006 |
Effects of parecoxib on plasma protein extravasation and c-fos expression in the rat.
Topics: Animals; Blood Proteins; Capillary Permeability; Cyclooxygenase 2 Inhibitors; Dura Mater; Isoxazoles; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2006 |
Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery.
Topics: Animals; Bicarbonates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Duodenum; Gastrointestinal Motility; Intestinal Absorption; Intestinal Mucosa; Isoxazoles; Lactones; Laparotomy; Male; Osmolar Concentration; Perfusion; Pyrazoles; Rats; Rats, Inbred Lew; Sodium Chloride; Sulfones | 2006 |
Parecoxib tolerability in patients with hypersensitivity to nonsteroidal anti-inflammatory drugs.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Hypersensitivity, Immediate; Immune Tolerance; Isoxazoles; Male; Middle Aged | 2006 |
Parecoxib impairs early metaphyseal bone healing in rats.
Topics: Animals; Cyclooxygenase Inhibitors; Female; Fracture Healing; Isoxazoles; Male; Rats; Rats, Sprague-Dawley | 2006 |
Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Humans; Isoxazoles; Male; Membrane Proteins; Pelvis; Pressure; Rats; Rats, Wistar; Receptors, Prostaglandin; RNA, Messenger; Ureter; Ureteral Obstruction | 2006 |
COX-2 inhibitors and early failure of free vascular flaps.
Topics: Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Pain, Postoperative; Sulfonamides; Surgical Flaps; Treatment Failure | 2006 |
Cyclooxygenase-2 inhibitors enhance shear stress-induced platelet aggregation.
Topics: Animals; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Stenosis; Cyclooxygenase Inhibitors; Isoxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Risk Factors; Shear Strength; Thrombosis; Ticlopidine | 2006 |
Parecoxib--getting to the heart of the matter.
Topics: Cardiovascular Diseases; Cyclooxygenase 2 Inhibitors; Drug Administration Schedule; Humans; Isoxazoles; Pain, Postoperative; Perioperative Care | 2006 |
Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Interleukin-10; Interleukin-6; Isoxazoles; Male; Pancreatitis; Rats; Rats, Wistar; Survival Rate; Taurocholic Acid | 2006 |
Effects of nitric oxide synthase inhibition with or without cyclooxygenase-2 inhibition on resting haemodynamics and responses to exendin-4.
Topics: Animals; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Exenatide; Isoxazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides; Rats; Rats, Sprague-Dawley; Rats, Wistar; Venoms | 2006 |
Interaction of non-steroidal anti-inflammatory drugs, etoricoxib and parecoxib sodium, with human serum albumin studied by fluorescence spectroscopy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Drug Interactions; Etoricoxib; Humans; Isoxazoles; Pyridines; Serum Albumin; Spectrometry, Fluorescence; Sulfones; Thermodynamics | 2006 |
Safety of parecoxib and valdecoxib after noncardiac surgery: lack of demonstration.
Topics: Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Pain, Postoperative; Safety; Sulfonamides | 2007 |
Intra-articular injection of the cyclooxygenase-2 inhibitor parecoxib attenuates osteoarthritis progression in anterior cruciate ligament-transected knee in rats: role of excitatory amino acids.
Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Cyclooxygenase 2 Inhibitors; Excitatory Amino Acids; Injections, Intra-Articular; Isoxazoles; Osteoarthritis; Rats; Rats, Wistar | 2007 |
COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction.
Topics: Animals; Aquaporin 2; Aquaporin 3; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diuresis; Electrolytes; Glomerular Filtration Rate; Isoxazoles; Kidney; Kidney Medulla; Male; Natriuresis; Polyuria; Prostaglandins; Rats; Rats, Inbred Strains; RNA, Messenger; Sodium Chloride Symporters; Time Factors; Ureteral Obstruction; Water Deprivation | 2007 |
Parecoxib - getting to the heart of the matter.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cyclooxygenase 2 Inhibitors; Evidence-Based Medicine; Humans; Isoxazoles | 2007 |
The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Exploratory Behavior; Hippocampus; Isoxazoles; Male; Maze Learning; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 2007 |
The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo.
Topics: Animals; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Injections, Intravenous; Isoxazoles; Kidney; Kidney Glomerulus; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Rats; Rats, Wistar; Reperfusion Injury; Time Factors | 2007 |
Modulation of mucosal permeability by vasoactive intestinal peptide or lidocaine affects the adjustment of luminal hypotonicity in rat duodenum.
Topics: Anesthetics, Local; Animals; Bicarbonates; Biological Transport; Blood Pressure; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Duodenum; Gastrointestinal Agents; Gastrointestinal Motility; Infusions, Intravenous; Intestinal Absorption; Intestinal Mucosa; Isoxazoles; Lidocaine; Male; Osmolar Concentration; Perfusion; Rats; Rats, Inbred Lew; Vasoactive Intestinal Peptide | 2007 |
The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs.
Topics: Blotting, Western; Cell Cycle Proteins; Chromatography, High Pressure Liquid; COP9 Signalosome Complex; Cullin Proteins; Curcumin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; HeLa Cells; Humans; Immunoprecipitation; Isoxazoles; Multiprotein Complexes; Peptide Hydrolases; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination | 2007 |
Improvement of cardiac function with parecoxib, a cyclo-oxygenase-2 inhibitor, in a rat model of ischemic heart failure.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Echocardiography; Heart Failure; Heart Function Tests; Isoxazoles; Male; Myocardial Ischemia; Myocardium; Rats; Rats, Wistar | 2007 |
Postnatal adrenalectomy impairs urinary concentrating ability by increased COX-2 and leads to renal medullary injury.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Corticosterone; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Isoxazoles; Kidney Medulla; Male; Rats; Rats, Sprague-Dawley; Sodium Chloride; Urine; Weight Gain | 2007 |
Tocolytic effect of parecoxib, a new parenteral cyclo-oxygenase-2-specific inhibitor, on the spontaneous and prostaglandin-induced contractions of rat isolated myometrium.
Topics: Animals; Area Under Curve; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Isometric Contraction; Isoxazoles; Myometrium; Rats; Rats, Wistar; Time Factors; Tocolytic Agents; Uterine Contraction | 2007 |
Postoperative administration of the analgesic tramadol, but not the selective cyclooxygenase-2 inhibitor parecoxib, abolishes postoperative hyperalgesia in a new model of postoperative pain in rats.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Hyperalgesia; Isoxazoles; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Tramadol | 2007 |
Inhibition of cyclooxygenase-2 down-regulates osteoclast and osteoblast differentiation and favours adipocyte formation in vitro.
Topics: Adipocytes; Animals; Cattle; Cell Differentiation; Cell Lineage; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Indomethacin; Isoxazoles; Male; Mesenchymal Stem Cells; Mice; Nitrobenzenes; Osteoblasts; Osteoclasts; Rats; Rats, Sprague-Dawley; Sulfonamides | 2007 |
Orthodontic tooth movement after different coxib therapies.
Topics: Alveolar Process; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cephalometry; Cyclooxygenase 2 Inhibitors; Gingiva; Isoxazoles; Lactones; Male; Molar; Orthodontic Wires; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Sulfones; Time Factors; Tooth Movement Techniques | 2007 |
Comparative study of the effect of luminal hypotonicity on mucosal permeability in rat upper gastrointestinal tract.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Duodenum; Gastric Mucosa; Hydrogen-Ion Concentration; Hypotonic Solutions; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Inulin; Isoxazoles; Jejunum; Male; Methylglucosides; Osmolar Concentration; Permeability; Rats; Rats, Inbred Strains; Sodium Chloride; Stomach; Upper Gastrointestinal Tract; Urea | 2008 |
Protective effects of parecoxib, a cyclo-oxygenase-2 inhibitor, in postinfarction remodeling in the rat.
Topics: Animals; Apoptosis; Arterioles; Cyclooxygenase 2 Inhibitors; Cytokines; Echocardiography; Heart; Isoxazoles; Male; Myocardial Infarction; Myocardium; Organ Size; Rats; Rats, Wistar; Survival Analysis; Ventricular Remodeling | 2007 |
Dosage adjustments in hepatic dysfunction.
Topics: Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Labeling; Humans; Isoxazoles; Liver Diseases | 2007 |
Serotonin mediates PGE2 overexpression through 5-HT2A and 5-HT3 receptor subtypes in serum-free tissue culture of macrophage-like synovial cells.
Topics: Aged; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Humans; Indoles; Interleukin-1beta; Isoxazoles; Ketanserin; Leukotriene B4; Macrophages; Middle Aged; Osteoarthritis; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin, 5-HT3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Serotonin Agents; Serotonin Antagonists; Synovial Membrane; Tropisetron; Tumor Necrosis Factor-alpha | 2008 |
Negative effect of parecoxib on bone mineral during fracture healing in rats.
Topics: Animals; Bone Density; Cyclooxygenase Inhibitors; Female; Fracture Fixation, Internal; Fracture Healing; Isoxazoles; Rats; Rats, Wistar; Stress, Mechanical; Tibial Fractures | 2008 |
The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits.
Topics: Animals; Bone and Bones; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indomethacin; Injections, Subcutaneous; Isoxazoles; Male; Meloxicam; Ossification, Heterotopic; Osteogenesis; Rabbits; Radiography; Thiazines; Thiazoles | 2009 |
Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture.
Topics: Animals; Cyclooxygenase Inhibitors; Femoral Fractures; Fracture Fixation, Intramedullary; Fracture Healing; Isoxazoles; Male; Radiography; Rats; Rats, Wistar | 2009 |
COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.
Topics: Animals; Blotting, Western; Brain; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Gene Expression Regulation, Enzymologic; Hindlimb; Hyperalgesia; Inflammation; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Zymosan | 2008 |
COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex.
Topics: Acute Disease; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Isoxazoles; Kidney Cortex; Kidney Diseases; Lipopolysaccharides; Male; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Rats; Rats, Sprague-Dawley | 2009 |
The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.
Topics: Animals; Body Temperature; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Fever; Genotype; Immunoassay; Immunohistochemistry; Interleukin-6; Isoxazoles; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Viscera | 2009 |
Influence of parecoxib (cox-2 inhibitor) in experimental pleurodesis.
Topics: Animals; Biomarkers; Brazil; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Isoxazoles; Lung; Pleura; Pleural Diseases; Pleurodesis; Rabbits; Random Allocation; Silver Nitrate; Talc | 2009 |
Cyclooxygenase 2 inhibition suppresses tubuloglomerular feedback: roles of thromboxane receptors and nitric oxide.
Topics: Animals; Arginine; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Fatty Acids, Unsaturated; Feedback, Physiological; Hydrazines; Isoxazoles; Kidney Glomerulus; Kidney Tubules; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Vasoconstriction | 2009 |
The effect of parecoxib and indometacin on tendon-to-bone healing in a bone tunnel: an experimental study in rats.
Topics: Animals; Anterior Cruciate Ligament; Biomechanical Phenomena; Bone Density; Cyclooxygenase Inhibitors; Female; Indomethacin; Isoxazoles; Random Allocation; Rats; Rats, Wistar; Stress, Mechanical; Tendons; Wound Healing | 2009 |
Negative effects of parecoxib and indomethacin on tendon healing: an experimental study in rats.
Topics: Animals; Cyclooxygenase Inhibitors; Female; Indomethacin; Isoxazoles; Random Allocation; Rats; Rats, Wistar; Recovery of Function; Tendons; Tensile Strength; Treatment Outcome; Wound Healing | 2009 |
Parecoxib and indomethacin delay early fracture healing: a study in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Female; Fracture Healing; Indomethacin; Isoxazoles; Rats; Rats, Wistar; Time Factors | 2009 |
Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion.
Topics: Acute Disease; Animals; Apoptosis; Coronary Stenosis; Coronary Vessels; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Echocardiography; Injections, Intraperitoneal; Isoxazoles; Ligation; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Ventricular Remodeling | 2009 |
Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Extremities; Inflammation; Isoenzymes; Isoxazoles; Ketoprofen; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley | 2009 |
Electroencephalographic responses of tramadol, parecoxib and morphine to acute noxious electrical stimulation in anaesthetised dogs.
Topics: Analgesics; Anesthesia; Animals; Cyclooxygenase 2 Inhibitors; Dogs; Dose-Response Relationship, Drug; Drug Evaluation; Electric Stimulation; Electrocardiography; Electroencephalography; Female; Heart Rate; Isoxazoles; Male; Morphine; Narcotics; Tramadol | 2010 |
Parecoxib does not suppress thromboxane synthesis in newborn piglets with group B streptococcal sepsis.
Topics: Animals; Animals, Newborn; Cyclooxygenase 2 Inhibitors; Dinoprostone; Epoprostenol; Gene Expression Regulation; Hemodynamics; Indomethacin; Inflammation; Isoxazoles; Lung; Platelet Count; Receptors, Prostaglandin E; Sepsis; Streptococcal Infections; Streptococcus agalactiae; Swine; Thromboxanes | 2009 |
Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers.
Topics: Adenomatous Polyposis Coli; Animals; Antineoplastic Agents; beta Catenin; Cell Line, Tumor; Cell Survival; Colonic Polyps; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; DNA-Binding Proteins; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, APC; Humans; Isoxazoles; Lactones; Mice; Mice, Mutant Strains; Nuclear Receptor Subfamily 4, Group A, Member 2; Oligonucleotide Array Sequence Analysis; Osteopontin; Promoter Regions, Genetic; RNA Interference; Signal Transduction; Sulfones; Time Factors; Transcription Factors; Transfection; Wnt Proteins | 2009 |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model.
Topics: Angiogenesis Inhibitors; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Endometriosis; Female; Isoxazoles; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Effects of Parecoxib and Fentanyl on nociception-induced cortical activity.
Topics: Action Potentials; Analgesics, Opioid; Animals; Arousal; Cerebral Cortex; Cyclooxygenase 2 Inhibitors; Electroencephalography; Electrophysiology; Evoked Potentials; Fentanyl; Gyrus Cinguli; Heart Rate; Isoxazoles; Neurons; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Respiration; Somatosensory Cortex | 2010 |
Cyclooxygenase 2 inhibition exacerbates AQP2 and pAQP2 downregulation independently of V2 receptor abundance in the postobstructed kidney.
Topics: Adenylyl Cyclases; Animals; Aquaporin 2; Cyclooxygenase 2 Inhibitors; Down-Regulation; Isoxazoles; Kidney; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Reperfusion Injury; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1; Vasopressins | 2010 |
Multimodal pain management following minimally invasive total knee arthroplasty: an experience in 3-dose parecoxib.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Combined Modality Therapy; Cyclooxygenase 2 Inhibitors; Female; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Minimally Invasive Surgical Procedures; Morphine; Pain Measurement; Pain, Postoperative; Recovery of Function; Treatment Outcome | 2009 |
The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Cell Count; Cell Death; Cerebral Cortex; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Electrodes, Implanted; Electroencephalography; Enzyme-Linked Immunosorbent Assay; Epilepsy, Temporal Lobe; Female; Isoxazoles; Motor Activity; Neurons; Neuroprotective Agents; Pilocarpine; Random Allocation; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Statistics, Nonparametric; Sulfonamides; Video Recording | 2010 |
Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cattle; Crystallography, X-Ray; Cyclooxygenase 2 Inhibitors; Etoricoxib; In Vitro Techniques; Isoxazoles; Lactoferrin; Models, Molecular; Peptide Fragments; Protein Binding; Protein Conformation; Pyridines; Sulfonamides; Sulfones | 2010 |
Short-term treatment with COX-2 inhibitors does not impair fracture healing.
Topics: Animals; Bone Density; Cyclooxygenase 2 Inhibitors; Diclofenac; Fracture Healing; Isoxazoles; Male; Rats; Rats, Wistar; Sulfonamides | 2010 |
Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue.
Topics: Amino Acids; Animals; Binding, Competitive; Brain Chemistry; Cyclic AMP; Cyclohexanols; Cyclooxygenase 2 Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Isoxazoles; Male; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sulfonamides; Transfection | 2011 |
Parecoxib and fatal skin reactions: when will this drug be withdrawn from the European Union market?
Topics: Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Stevens-Johnson Syndrome | 2010 |
Effects of Cox inhibitors on bone and tendon healing.
Topics: Animals; Biomechanical Phenomena; Bone Density; Cyclooxygenase Inhibitors; Female; Fracture Healing; Fractures, Bone; Indomethacin; Isoxazoles; Models, Animal; Pain, Postoperative; Rats; Rats, Wistar; Tendon Injuries; Treatment Outcome; Wound Healing | 2011 |
Effects of intramuscular parecoxib administration on vasospasm in an experimental subarachnoid hemorrhage model.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Injections, Intramuscular; Isoxazoles; Male; Rabbits; Random Allocation; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2011 |
Protective effects of COX-2 inhibitor on titanium-particle-induced inflammatory osteolysis via the down-regulation of RANK/RANKL.
Topics: Acid Phosphatase; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Immunohistochemistry; Interleukin-1beta; Isoenzymes; Isoxazoles; Membranes; Mice; Mice, Inbred BALB C; Osteoclasts; Osteogenesis; Osteolysis; Particulate Matter; Protective Agents; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Tartrate-Resistant Acid Phosphatase; Titanium; Tumor Necrosis Factor-alpha | 2011 |
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Thrombosis | 2011 |
The neurological safety of epidural parecoxib in rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Ethanol; Gait; Injections, Epidural; Isoxazoles; Male; Neurologic Examination; Neurotoxicity Syndromes; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Risk Assessment; Spinal Cord; Time Factors | 2011 |
Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology.
Topics: Animals; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Dogs; Isoxazoles; Sensitivity and Specificity; Spectrometry, Fluorescence; Sulfonamides | 2011 |
Controversy of non-steroidal anti-inflammatory drugs and intracranial surgery: et ne nos inducas in tentationem?
Topics: Craniotomy; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Male; Pain, Postoperative | 2011 |
Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β.
Topics: Animals; Apoptosis; Blotting, Western; Cyclooxygenase 2 Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; In Situ Nick-End Labeling; Ischemia; Isoxazoles; Male; Neurons; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley | 2012 |
Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice.
Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Esophageal Neoplasms; Female; Gene Expression; Humans; Indomethacin; Isoxazoles; Male; Mice; Mice, Nude; Random Allocation; Receptors, Prostaglandin E; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
[Analgesic effect of COX inhibitors and its mechanism in a rat model of neuropathic pain].
Topics: Analgesics; Animals; Constriction; Cyclooxygenase 2 Inhibitors; Isoxazoles; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Spinal Cord | 2011 |
Preconditioning of intravenous parecoxib attenuates focal cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Blotting, Western; Brain Ischemia; Injections, Intravenous; Isoxazoles; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2011 |
Short- and long-term effects of selective cyclooxygenase-2 inhibitor paracoxib on ileal and colonic anastomosis in rats.
Topics: Anastomosis, Surgical; Animals; Colon; Cyclooxygenase 2 Inhibitors; Ileum; Isoxazoles; Rats; Rats, Wistar; Surgical Wound Dehiscence; Time Factors | 2012 |
Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Flow Cytometry; Glioblastoma; Immunohistochemistry; Immunotherapy, Adoptive; Interferon-gamma; Isoxazoles; Male; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 2012 |
Fixed drug eruption caused by etoricoxib with tolerance to celecoxib and parecoxib.
Topics: Aged; Arm; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Eruptions; Etoricoxib; Female; Humans; Isoxazoles; Leg Dermatoses; Low Back Pain; Patch Tests; Pyrazoles; Pyridines; Sulfonamides; Sulfones | 2012 |
The selective cyclooxygenase-2 inhibitor parecoxib markedly improves the ability of the duodenum to regulate luminal hypertonicity in anaesthetized rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Duodenum; Isoxazoles; Male; Models, Animal; Muscle Contraction; Muscle Hypertonia; Muscle, Smooth; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Regression Analysis; Saline Solution, Hypertonic; Unconsciousness | 2012 |
Transfer of parecoxib and its primary active metabolite valdecoxib via transitional breastmilk following intravenous parecoxib use after cesarean delivery: a comparison of naive pooled data analysis and nonlinear mixed-effects modeling.
Topics: Adult; Biological Transport; Cesarean Section; Cyclooxygenase 2 Inhibitors; Female; Humans; Infant, Newborn; Injections, Intravenous; Isoxazoles; Male; Milk, Human; Models, Biological; Nonlinear Dynamics; Sulfonamides | 2012 |
Disruption of cyclooxygenase-2 prevents downregulation of cortical AQP2 and AQP3 in response to bilateral ureteral obstruction in the mouse.
Topics: Animals; Aquaporin 2; Aquaporin 3; Blotting, Western; Body Weight; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Immunohistochemistry; Isoxazoles; Kidney; Kidney Cortex; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Polymerase Chain Reaction; RNA; Ureteral Obstruction | 2012 |
Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats.
Topics: Aging; Anesthetics, Intravenous; Animals; Blotting, Western; Cognition Disorders; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Hippocampus; Isoxazoles; Male; Maze Learning; Memory; Memory Disorders; Methyl Ethers; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Sevoflurane; Synapses | 2012 |
Development of a population pharmacokinetic model for parecoxib and its active metabolite valdecoxib after parenteral parecoxib administration in children.
Topics: Adult; Age Factors; Algorithms; Biotransformation; Child; Child, Preschool; Computer Simulation; Cyclooxygenase 2 Inhibitors; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infant; Infusions, Parenteral; Isoxazoles; Male; Models, Statistical; Nonlinear Dynamics; Population; Prospective Studies; Reproducibility of Results; Sulfonamides | 2012 |
The cyclooxygenase-2 inhibitor parecoxib inhibits surgery-induced proinflammatory cytokine expression in the hippocampus in aged rats.
Topics: Aging; Animals; Cognition Disorders; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Encephalitis; Gene Expression; Hippocampus; Interleukin-1beta; Isoxazoles; Male; Postoperative Complications; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2012 |
Parecoxib suppresses CHOP and Foxo1 nuclear translocation, but increases GRP78 levels in a rat model of focal ischemia.
Topics: Animals; Apoptosis; Brain Ischemia; Endoplasmic Reticulum Stress; Forkhead Transcription Factors; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Infarction, Middle Cerebral Artery; Isoxazoles; Male; Nerve Tissue Proteins; Neuroprotective Agents; Protein Transport; Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Transcription Factor CHOP | 2013 |
Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain.
Topics: Animals; Cannabinoids; Chronic Disease; Constriction, Pathologic; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Female; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cannabinoid, CB1; Sciatic Neuropathy; Species Specificity; Treatment Outcome | 2013 |
[Economic analysis of parecoxib in the management of postsurgical pain in gynecology].
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Costs and Cost Analysis; Decision Trees; Female; Gynecologic Surgical Procedures; Humans; Isoxazoles; Ketorolac; Morphine; Pain, Postoperative | 2012 |
Prevention of peridural fibrosis using a cyclooxygenase-2 inhibitor (nonsteroidal anti-inflammatory drug) soaked in absorbable gelatin sponge: an experimental comparative animal model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Dura Mater; Failed Back Surgery Syndrome; Female; Fibroblasts; Fibrosis; Gelatin Sponge, Absorbable; Humans; Isoxazoles; Laminectomy; Lumbar Vertebrae; Male; Models, Animal; Postoperative Complications; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2013 |
Dynamics of Parecoxib or Meloxicam effect on acute postoperative pain after orthopedic surgical interventions: comparative study in hospitalized women and men.
Topics: Adolescent; Adult; Aged; Analgesia; Analgesics; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Male; Meloxicam; Middle Aged; Orthopedic Procedures; Pain, Postoperative; Thiazines; Thiazoles; Young Adult | 2011 |
A cost-effectiveness analysis of parecoxib in the management of postoperative pain in the Greek health care setting.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Greece; Humans; Isoxazoles; Pain Measurement; Pain, Postoperative; Randomized Controlled Trials as Topic; Treatment Outcome | 2013 |
Effects of parecoxib on the prevention of postoperative peritoneal adhesions in rats.
Topics: Anastomosis, Surgical; Animals; Burns, Electric; Cecum; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Injections, Intramuscular; Isoxazoles; Male; Peritoneal Diseases; Plasminogen Activator Inhibitor 1; Postoperative Complications; Rats; Rats, Sprague-Dawley; Tissue Adhesions; Tissue Plasminogen Activator; Wound Healing | 2013 |
Intratumoral COX-2 inhibition enhances GM-CSF immunotherapy against established mouse GL261 brain tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drug Synergism; Female; Flow Cytometry; Glioma; Granulocyte-Macrophage Colony-Stimulating Factor; Immunoenzyme Techniques; Immunotherapy; Intramolecular Oxidoreductases; Isoxazoles; Mice; Mice, Inbred C57BL; Prostaglandin-E Synthases; Sulfonamides; Tumor Cells, Cultured | 2014 |
A pre-emptive pain management protocol to support self-care following vitreo-retinal day surgery.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics; Female; Humans; Isoxazoles; Male; Middle Aged; Ophthalmic Solutions; Pain, Postoperative; Postoperative Care; Self Administration; Treatment Outcome; Vitreoretinal Surgery; Young Adult | 2014 |
Influence of non-steroidal anti-inflammatory drugs (NSAIDs) on osseointegration of dental implants in rabbit calvaria.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dental Implants; Diclofenac; Implants, Experimental; Isoxazoles; Osseointegration; Rabbits; Skull; X-Ray Microtomography | 2015 |
Ovarian hyperstimulation syndrome inhibition by targeting VEGF, COX-2 and calcium pathways: a preclinical randomized study.
Topics: Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Calcium Signaling; Cyclooxygenase 2 Inhibitors; Drug Evaluation, Preclinical; Female; Isoxazoles; Molecular Targeted Therapy; Ovarian Hyperstimulation Syndrome; Random Allocation; Rats; Rats, Wistar; Treatment Outcome; Vascular Endothelial Growth Factor A; Verapamil | 2014 |
Insights into in vitro binding of parecoxib to human serum albumin by spectroscopic methods.
Topics: Binding Sites; Circular Dichroism; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Isoxazoles; Molecular Docking Simulation; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thermodynamics | 2014 |
Cytokine and radical inhibition in septic intestinal barrier failure.
Topics: Animals; Cyclic N-Oxides; Cyclooxygenase 2 Inhibitors; Drug Evaluation, Preclinical; Free Radical Scavengers; Interleukin-6; Intestinal Mucosa; Isoxazoles; Lipopolysaccharides; Male; Multiple Organ Failure; NADPH Oxidases; Neutrophils; Permeability; Pyruvic Acid; Rats, Sprague-Dawley; Sepsis; Spin Labels; Vasoactive Intestinal Peptide | 2015 |
The effect of TSPP-mediated photodynamic therapy and Parecoxib in experimental tumours.
Topics: Analysis of Variance; Animals; Apoptosis; Biomarkers; Blotting, Western; Carcinoma 256, Walker; Cyclooxygenase 2; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; In Situ Nick-End Labeling; Isoxazoles; Male; Malondialdehyde; Necrosis; Photochemotherapy; Porphyrins; Rats | 2014 |
The Study of Different Approaches of Parecoxib Sodium Pretreatment on the Behavior of Rats with Neuropathic Pain.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Administration Schedule; Hot Temperature; Inflammation; Injections, Intraperitoneal; Injections, Spinal; Isoxazoles; Male; Neuralgia; Pain Management; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2015 |
Parecoxib: an enhancer of radiation therapy for colorectal cancer.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; Flow Cytometry; Humans; Hypoxia; Immunoenzyme Techniques; Isoxazoles; Male; Mice; Mice, Nude; Radiation-Sensitizing Agents; Tumor Cells, Cultured; X-Rays; Xenograft Model Antitumor Assays | 2015 |
Daily subcutaneous parecoxib injection for cancer pain: an open label pilot study.
Topics: Analgesics, Opioid; Analysis of Variance; Bone Neoplasms; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Hospital Units; Humans; Injections, Subcutaneous; Isoxazoles; Male; Neoplasm Metastasis; Pain Management; Pain Measurement; Palliative Care; Pilot Projects; Treatment Outcome; Victoria | 2015 |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Blood Pressure; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Isoxazoles; Kidney; Lipocalin-2; Lipocalins; Male; Prospective Studies; Proto-Oncogene Proteins; Random Allocation; Rats, Wistar; Reperfusion Injury; Reproducibility of Results; Severity of Illness Index; Time Factors; Treatment Outcome | 2015 |
Synergism between tramadol and parecoxib in the orofacial formalin test.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Facial Pain; Isoxazoles; Male; Mice; Pain Measurement; Tramadol | 2015 |
Parecoxib Protects Mouse Cortical Neurons Against OGD/R Induced Neurotoxicity by Up-Regulating Bcl-2.
Topics: Adenosine Triphosphate; Animals; Cell Death; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2 Inhibitors; Gene Knockdown Techniques; Glucose; Hypoxia, Brain; Isoxazoles; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Nervous System Diseases; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Reperfusion Injury; RNA, Small Interfering; Up-Regulation | 2015 |
The Effect of Cyclooxygenase Inhibition on Tendon-Bone Healing in an In Vitro Coculture Model.
Topics: Alkaline Phosphatase; Animals; Cell Survival; Coculture Techniques; Core Binding Factor Alpha 1 Subunit; Cyclooxygenase Inhibitors; Ibuprofen; Isoxazoles; Lipopolysaccharides; Mice; Osteoblasts; Tendons; Wound Healing | 2015 |
Comparison of Pain Thresholds and Analgesic Effects of Parecoxib Sodium in Surgical Patients of Different Racial and Religious Backgrounds.
Topics: Adolescent; Adult; Analgesia; Analgesics; Anesthesia, General; Humans; Isoxazoles; Male; Pain Measurement; Pain Threshold; Pain, Postoperative; Religion; Young Adult | 2015 |
COX-2 inhibition impairs mechanical stimulation of early tendon healing in rats by reducing the response to microdamage.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Cyclooxygenase 2 Inhibitors; Female; Hindlimb Suspension; Isoxazoles; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Tendon Injuries; Wound Healing | 2015 |
Paclitaxel-induced lung injury and its amelioration by parecoxib sodium.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Claudin-4; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Female; Intercellular Adhesion Molecule-1; Isoxazoles; Leukocytes; Lung; Lung Injury; Paclitaxel; Permeability; Rats; Rats, Wistar; Zonula Occludens-1 Protein | 2015 |
A comparison of parecoxib and thoracic epidural analgesia for postoperative analgesia following Nuss procedure.
Topics: Adolescent; Adult; Analgesia, Epidural; Cyclooxygenase 2 Inhibitors; Drug Administration Schedule; Female; Funnel Chest; Humans; Injections, Intravenous; Isoxazoles; Length of Stay; Male; Orthopedic Procedures; Pain Measurement; Pain, Postoperative; Retrospective Studies; Treatment Outcome; Young Adult | 2015 |
Pretreatment of parecoxib attenuates hepatic ischemia/reperfusion injury in rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Isoxazoles; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2015 |
[Parecoxib effects in the prevention of postoperative abdominal adhesions: randomized experimental study in rats].
Topics: Abdominal Wall; Animals; Cyclooxygenase 2 Inhibitors; Gastrointestinal Diseases; Injections, Intramuscular; Injections, Intraperitoneal; Isoxazoles; Male; Postoperative Complications; Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Adhesions | 2015 |
Parecoxib prevents complications in hepatocellular carcinoma patients receiving hepatic transarterial chemoembolization: a prospective score-matched cohort study.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cyclooxygenase 2 Inhibitors; Female; Fever; Humans; Isoxazoles; Length of Stay; Liver; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Palliative Care; Postoperative Nausea and Vomiting; Propensity Score; Prospective Studies | 2016 |
Simultaneous determination of parecoxib sodium and its active metabolite valdecoxib in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study after intravenous and intramuscular administration.
Topics: Administration, Intravenous; Animals; Chromatography, High Pressure Liquid; Injections, Intramuscular; Isoxazoles; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Sulfonamides; Tandem Mass Spectrometry | 2016 |
Transitional Study of Patient-Controlled Analgesia Morphine With Ketorolac to Patient-Controlled Analgesia Morphine With Parecoxib Among Donors in Adult Living Donor Liver Transplantation: A Single-Center Experience.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Humans; Isoxazoles; Ketorolac; Liver Transplantation; Living Donors; Male; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Retrospective Studies; Tissue and Organ Harvesting | 2016 |
[Effect of parecoxib on hippocampal inflammation and memory function in aged rats after splenectomy].
Topics: Animals; Cyclooxygenase 2; Hippocampus; Inflammation; Interleukin-1beta; Isoxazoles; Male; Memory; Rats; Rats, Sprague-Dawley; Splenectomy; Tumor Necrosis Factor-alpha | 2016 |
Analgesic requirements and pain experience after caesarean section under neuraxial anesthesia in women with preeclampsia.
Topics: Acetaminophen; Adult; Analgesics; Cesarean Section; Female; Humans; Isoxazoles; Oxycodone; Pain Measurement; Pain, Postoperative; Pre-Eclampsia; Pregnancy; Retrospective Studies; Treatment Outcome; Young Adult | 2016 |
Protective effects of parecoxib on rat primary astrocytes from oxidative stress induced by hydrogen peroxide.
Topics: Animals; Apoptosis; Astrocytes; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Hydrogen Peroxide; Isoxazoles; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species | 2016 |
A Novel Approach for the Control of Inflammatory Pain: Prostaglandin E2 Complexation by Randomly Methylated β-Cyclodextrins.
Topics: Animals; beta-Cyclodextrins; Computer Simulation; Cyclooxygenase 2 Inhibitors; Dinoprostone; Electrophoresis, Capillary; Hyperalgesia; Inflammation; Inflammation Mediators; Isoxazoles; Male; Methylation; Pain; Pain Measurement; Pain Threshold; Postural Balance; Rats; Rats, Wistar | 2017 |
[Application of multimodal analgesia in radical gastrectomy for gastric cancer patients: a prospective nonrandomized controlled study].
Topics: Acetaminophen; Amides; Analgesia, Patient-Controlled; China; Comparative Effectiveness Research; Defecation; Drug Combinations; Eating; Flatulence; Gastrectomy; Humans; Isoxazoles; Length of Stay; Oxycodone; Pain Management; Pain, Postoperative; Postoperative Complications; Prospective Studies; Recovery of Function; Ropivacaine; Stomach Neoplasms; Surgical Wound; Suture Techniques; Treatment Outcome; Walking | 2017 |
The efficacy of a multimodal analgesia protocol in preventing heterotopic ossification after acetabular fractures surgery.
Topics: Acetabulum; Adult; Aged; Analgesia; Celecoxib; Combined Modality Therapy; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Fractures, Bone; Humans; Isoxazoles; Male; Middle Aged; Ossification, Heterotopic; Pain Management; Pain, Postoperative; Retrospective Studies; Treatment Outcome; Young Adult | 2017 |
Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Caspase 3; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Endometriosis; Female; Isoxazoles; Matrix Metalloproteinase 9; Mice, Inbred C57BL; PPAR gamma; Proto-Oncogene Proteins c-akt; Telmisartan; Ultrasonography | 2017 |
Safety of parecoxib when used for more than 3 days for the management of postoperative pain.
Topics: Adult; Aged; Arthroplasty, Replacement, Hip; Cyclooxygenase 2 Inhibitors; Female; Gynecologic Surgical Procedures; Humans; Isoxazoles; Male; Middle Aged; Pain Management; Pain, Postoperative; Treatment Outcome; Young Adult | 2017 |
Cyclooxygenase-2 promotes pulmonary intravascular macrophage accumulation by exacerbating BMP signaling in rat experimental hepatopulmonary syndrome.
Topics: Animals; Bone Morphogenetic Protein 2; Carrier Proteins; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Endothelium, Vascular; Hepatopulmonary Syndrome; Injections, Intraperitoneal; Injections, Intravenous; Isoxazoles; Lung; Macrophage Activation; Macrophages, Alveolar; Microvessels; Neovascularization, Pathologic; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction | 2017 |
Use of parecoxib by continuous subcutaneous infusion for cancer pain in a hospice population.
Topics: Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cancer Pain; Female; Hospice Care; Hospices; Humans; Infusions, Subcutaneous; Isoxazoles; Male; Middle Aged; Pain Management; Pain Measurement; Retrospective Studies; Treatment Outcome | 2018 |
The action of anti-inflammatory agents in healthy temporomandibular joint synovial tissues is sex-dependent.
Topics: Administration, Oral; Animals; Cartilage, Articular; Cytokines; Dexamethasone; Enzyme-Linked Immunosorbent Assay; Female; Glucosamine; Injections; Isoxazoles; Male; Rats; Rats, Wistar; Sex Factors; Synovial Membrane; Temporomandibular Joint | 2018 |
Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice.
Topics: Animals; Anti-Anxiety Agents; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression; Hippocampus; Isoxazoles; Male; Maze Learning; Mice; Mice, Inbred ICR; Nootropic Agents; Random Allocation; Synaptophysin | 2017 |
COX‑2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression.
Topics: Animals; Antineoplastic Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Progression; Endothelial Cells; Female; Glucose; Glycolysis; Isoxazoles; Mice, Inbred C57BL; Neoplasms; Ovarian Neoplasms; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2018 |
The Investigation of the Cox-2 Selective Inhibitor Parecoxib Effects in Spinal Cord Injury in Rat.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Humans; Injections, Intraperitoneal; Isoxazoles; Laminectomy; Male; Methylprednisolone; Rats; Spinal Cord; Spinal Cord Injuries; Treatment Outcome | 2019 |
Parecoxib's effects on anastomotic and abdominal wound healing: a randomized Controlled trial.
Topics: Abdominal Injuries; Anastomotic Leak; Animals; Collagen; Cyclooxygenase 2 Inhibitors; Isoxazoles; Male; Random Allocation; Rats; Rats, Wistar; Wound Healing | 2018 |
Confounding and Adjustment Factors in the Effect of Intravenous Parecoxib on Shoulder Pain after Thoracotomy?
Topics: Double-Blind Method; Humans; Injections, Intravenous; Isoxazoles; Pain, Postoperative; Shoulder Pain; Thoracotomy | 2018 |
Response: "Confounding and Adjustment Factors in the Effect of Intravenous Parecoxib on Shoulder Pain After Thoracotomy?"
Topics: Double-Blind Method; Humans; Injections, Intravenous; Isoxazoles; Pain, Postoperative; Shoulder Pain; Thoracotomy | 2018 |
Study on the effects of parecoxib on hypothalamus orexin neuron of cerebral infarction rats.
Topics: Animals; Cerebral Infarction; Hypothalamus; Isoxazoles; Male; Neurons; Orexins; Rats; Rats, Sprague-Dawley | 2018 |
Simultaneous determination of parecoxib and its main metabolites valdecoxib and hydroxylated valdecoxib in mouse plasma with a sensitive LC-MS/MS method to elucidate the decreased drug metabolism of tumor bearing mice.
Topics: Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme System; Drug Monitoring; Female; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Neoplasms; Oxazoles; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Tandem Mass Spectrometry; Xenograft Model Antitumor Assays | 2018 |
Novel multimodal analgesia regimen improves post-TACE pain in patients with hepatocellular carcinoma.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cost-Benefit Analysis; Female; Health Care Costs; Humans; Isoxazoles; Liver Neoplasms; Male; Middle Aged; Pain, Postoperative; Patient Satisfaction; Postoperative Nausea and Vomiting; Sufentanil | 2018 |
Influence of Cyclooxygenase-2 Inhibitors on Kynurenic Acid Production in Rat Brain in Vitro.
Topics: Animals; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Humans; Isoxazoles; Kynurenic Acid; Male; Molecular Docking Simulation; Niflumic Acid; Rats, Wistar; Tissue Culture Techniques; Transaminases | 2019 |
Protective Effect of Dexamethasone on Lipopolysaccharide-Induced Inhibition of Contractile Function of Isolated Lymphatic Vessels and Nodes.
Topics: Amidines; Animals; Anti-Inflammatory Agents; Benzylamines; Cattle; Cyclooxygenase 2; Dexamethasone; Endothelial Cells; Gene Expression; Isoxazoles; Lipopolysaccharides; Lymph Nodes; Lymphatic Vessels; Male; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Tissue Culture Techniques | 2018 |
Quantitative and systems pharmacology 4. Network-based analysis of drug pleiotropy on coronary artery disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Products; Coronary Artery Disease; Dexamethasone; Drug Repositioning; Humans; Isoxazoles; Systems Biology | 2019 |
Parecoxib, a selective blocker of cyclooxygenase-2, directly inhibits neuronal delayed-rectifier K
Topics: Animals; Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; Isoxazoles; Mice; Neurons; Potassium Channel Blockers; Rats; Sodium Channel Blockers | 2019 |
Cross-sectional survey of off-label and unlicensed prescribing for inpatients at a paediatric teaching hospital in Western Australia.
Topics: Australia; Child; Child, Preschool; Clonidine; Drug Administration Routes; Drug Prescriptions; Female; Humans; Inpatients; Isoxazoles; Legislation, Drug; Male; Midazolam; Off-Label Use; Oxycodone; Pediatrics | 2019 |
Effects of Parecoxib on Pain Threshold and Inflammatory Factors IL-1β, IL-6 and TNF-
Topics: Animals; Bone Neoplasms; Cancer Pain; Cyclooxygenase 2 Inhibitors; Down-Regulation; Female; Hyperalgesia; Inflammation; Interleukin-1beta; Interleukin-6; Isoxazoles; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord; Tumor Necrosis Factor-alpha | 2019 |
Parecoxib improves the cognitive function of POCD rats via attenuating COX-2.
Topics: Animals; Apoptosis; Cognition; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Hippocampus; Humans; Isoxazoles; Male; Neurons; Postoperative Cognitive Complications; Rats; Up-Regulation | 2019 |
[Clinical efficacy of intra-articular parecoxib injection for the treatment of early knee osteoarthritis].
Topics: Adult; Aged; Female; Humans; Injections, Intra-Articular; Isoxazoles; Male; Middle Aged; Osteoarthritis, Knee | 2019 |
Parecoxib Improves the Outcomes of Acute Mild and Moderate Pancreatitis: A 3-Year Matched Cohort Study Based on a Prospective Database.
Topics: Acute Disease; Adult; Bacterial Infections; Cohort Studies; Cyclooxygenase 2 Inhibitors; Databases, Factual; Disease Progression; Female; Fever; Humans; Isoxazoles; Male; Middle Aged; Outcome Assessment, Health Care; Pancreatitis; Protective Agents; Severity of Illness Index | 2019 |
Elucidating the mechanisms of action of parecoxib in the MG-63 osteosarcoma cell line.
Topics: Apoptosis; Bone Neoplasms; Cell Cycle; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Osteosarcoma; Tumor Cells, Cultured | 2020 |
Parecoxib as an adjunct therapy for the treatment of refractory non-surgical cancer pain.
Topics: Adult; Aged; Aged, 80 and over; Australia; Cancer Pain; Cohort Studies; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Pain Measurement; Retrospective Studies; Young Adult | 2020 |
Parecoxib protects against myocardial ischemia/reperfusion via targeting PKA-CREB signaling pathway.
Topics: Apoptosis; Humans; Isoxazoles; Myocardial Reperfusion Injury; Signal Transduction | 2022 |
Intraoperative use of single dose of nonsteroidal anti-inflammatory drugs was not associated with cancer recurrence and mortality after bladder cancer surgery: a retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Disease-Free Survival; Humans; Intraoperative Care; Isoxazoles; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Urinary Bladder Neoplasms | 2020 |
Nonsteroidal anti-inflammatory drugs alleviate severity of post-endoscopic retrograde cholangiopancreatography pancreatitis by inhibiting inflammation and reducing apoptosis.
Topics: Acinar Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cholangiopancreatography, Endoscopic Retrograde; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Gene Expression; Indomethacin; Isoxazoles; Pancreatitis; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2020 |
Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Injections, Intramuscular; Isoxazoles; Molecular Structure; Sulfonamides; Tandem Mass Spectrometry | 2020 |
Parecoxib exhibits anti-inflammatory and neuroprotective effects in a rat model of transient global cerebral ischemia.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Ischemic Attack, Transient; Isoxazoles; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2020 |
Comparison of the short-term outcomes of using DST and PPH staplers in the treatment of grade III and IV hemorrhoids.
Topics: Acetaminophen; Anal Canal; Analgesics; Anus Diseases; Constriction, Pathologic; Equipment Design; Female; Hemorrhage; Hemorrhoidectomy; Hemorrhoids; Humans; Intestinal Mucosa; Isoxazoles; Male; Middle Aged; Organ Size; Pain, Postoperative; Postoperative Complications; Retrospective Studies; Surgical Staplers; Treatment Outcome; Urinary Retention | 2020 |
Paracoxib Alleviates Ventilator-Induced Lung Injury Through Functional Modulation of Lung-Recruited CD11bloLy6Chi Monocytes.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Isoxazoles; Lung; Male; Mice; Mice, Inbred C57BL; Monocytes; Ventilator-Induced Lung Injury | 2021 |
Parecoxib for opioid-induced hyperalgesia.
Topics: Adult; Analgesics, Opioid; Cancer Pain; Humans; Hyperalgesia; Isoxazoles; Male; Treatment Outcome | 2021 |
Impact of Non-Steroidal Anti-Inflammatory Drugs on Recurrence and Survival after Melanoma Surgery: A Cohort Study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Female; Humans; Isoxazoles; Kaplan-Meier Estimate; Ketorolac; Male; Melanoma; Melanoma, Cutaneous Malignant; Middle Aged; Neoplasm Recurrence, Local; Perioperative Period; Piroxicam; Retrospective Studies; Sentinel Lymph Node Biopsy; Skin Neoplasms; Treatment Outcome | 2020 |
Parecoxib prevents nucleus pulposus cells apoptosis by suppressing endoplasmic reticulum stress.
Topics: Adult; Apoptosis; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Female; Humans; Interleukin-1beta; Isoxazoles; Male; Nucleus Pulposus | 2020 |
Parecoxib alleviates the inflammatory effect of leukocyte-rich platelet-rich plasma in normal rabbit tendons.
Topics: Animals; Isoxazoles; Leukocytes; Platelet-Rich Plasma; Rabbits; Tendinopathy; Tendons | 2020 |
Effect of Parecoxib Sodium on Myocardial Ischemia-Reperfusion Injury Rats.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cytokines; Heart Function Tests; Inflammation Mediators; Isoxazoles; Myocardial Reperfusion Injury; Myocardium; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction | 2021 |
Evaluating the association of preoperative parecoxib with acute pain trajectories after video-assisted thoracoscopic surgery: a single-centre cohort study in Taiwan.
Topics: Acute Pain; Aged; Cohort Studies; Double-Blind Method; Female; Humans; Isoxazoles; Pain, Postoperative; Retrospective Studies; Taiwan; Thoracic Surgery, Video-Assisted | 2021 |
Parecoxib improves atherosclerotic plaque stability by suppressing inflammation and inhibiting matrix metalloproteinases production.
Topics: Animals; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Inflammation Mediators; Isoxazoles; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic | 2021 |
A commentary on "Effects of parecoxib after pancreaticoduodenectomy: A single center randomized controlled trial" (Int J Surg Epub ahead of Print).
Topics: Humans; Isoxazoles; Pancreatectomy; Pancreaticoduodenectomy | 2021 |
Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition.
Topics: Aging; Animals; Calcium-Binding Proteins; Cyclooxygenase 2; Cytokines; Dinoprostone; Dopamine Plasma Membrane Transport Proteins; Isoxazoles; Male; Microfilament Proteins; Microglia; Mitochondria; Mitochondrial Proteins; Motor Activity; Organelle Biogenesis; Protein Kinases; Rats; Rats, Sprague-Dawley; Substantia Nigra; Superoxide Dismutase; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases | 2021 |
Perioperative Outcomes of Patients Who Were Not Candidates for Additional Nonsteroidal Anti-inflammatory Drugs in a Multimodal Pain Control Regimen for Total Knee Arthroplasty.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Knee; Celecoxib; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Retrospective Studies | 2021 |
A commentary on "Effects of parecoxib after pancreaticoduodenectomy: A single center randomized controlled trial" (Int J Surg 2021; 28: 105962).
Topics: Anastomosis, Surgical; Humans; Isoxazoles; Pancreatectomy; Pancreaticoduodenectomy | 2021 |
Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing non-cardiac surgery: a retrospective cohort analysis.
Topics: Acute Kidney Injury; Adult; Cohort Studies; Humans; Isoxazoles; Postoperative Complications; Retrospective Studies; Risk Factors | 2021 |
Protective effect of parecoxib sodium against ischemia reperfusion‑induced intestinal injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cyclooxygenase 2 Inhibitors; Inflammation; Isoxazoles; Male; Malondialdehyde; Oxidative Stress; Peroxidase; Protective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2021 |
Parecoxib mitigates lung ischemia-reperfusion injury in rats by reducing oxidative stress and inflammation and up-regulating HO-1 expression.
Topics: Animals; Heme Oxygenase-1; Inflammation; Isoxazoles; Lung; Lung Injury; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2021 |
Parecoxib ameliorates renal toxicity and injury in sepsis-induced mouse model and LPS-induced HK-2 cells.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cyclooxygenase 2; Disease Models, Animal; I-kappa B Kinase; Inflammation; Isoxazoles; Lipopolysaccharides; Mice; NF-kappa B; Sepsis | 2022 |
Parecoxib inhibits esophageal squamous cell carcinoma progression via the PDK1-AKT pathway.
Topics: Animals; Cell Line, Tumor; Cell Movement; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Isoxazoles; Matrix Metalloproteinase 2; Mice; Proto-Oncogene Proteins c-akt | 2022 |
Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing radical mastectomy: a retrospective cohort analysis.
Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cohort Studies; Female; Humans; Incidence; Isoxazoles; Mastectomy; Mastectomy, Radical; Postoperative Complications; Retrospective Studies; Risk Factors | 2022 |
Effects of fascia iliaca compartment block as an adjunctive management to parecoxib for pain control after total hip arthroplasty.
Topics: Arthroplasty, Replacement, Hip; C-Reactive Protein; Fascia; Humans; Interleukin-6; Isoxazoles; Nerve Block; Pain, Postoperative; Retrospective Studies | 2022 |
Parecoxib expresses anti-metastasis effect through inhibition of epithelial-mesenchymal transition and the Wnt/β-catenin signaling pathway in human colon cancer DLD-1 cell line.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Cadherins; Cell Line; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Cyclooxygenase 2; Epithelial-Mesenchymal Transition; Glycogen Synthase Kinase 3 beta; Humans; Isoxazoles; Proto-Oncogene Proteins c-akt; Vimentin; Wnt Signaling Pathway | 2022 |
Nano-Carbon-Based Application of Parecoxib Sodium Combined with Hydromorphone in Preventing Anesthesia Hyperalgesia Caused by Remifentanil after Thyroidectomy.
Topics: Analgesics, Opioid; Anesthesia; Humans; Hydromorphone; Hyperalgesia; Isoxazoles; Pain; Piperidines; Remifentanil; Thyroidectomy | 2022 |
Parecoxib sodium alleviates ischemia reperfusion-induced pulmonary injury via inhibiting ERK/NF-κB and further activating the HIF-1α pathway.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Hypoxia-Inducible Factor 1, alpha Subunit; Isoxazoles; Lung; Lung Injury; NF-kappa B; Rats; Reperfusion; Reperfusion Injury | 2022 |
Сyclooxygenase-2 Inhibitor Parecoxib Reduces LPS-Induced Activation of BV2 Microglia Cells.
Topics: Animals; Caspase 1; Cyclooxygenase 2 Inhibitors; Inflammasomes; Isoxazoles; Lipopolysaccharides; Mice; Microglia; NLR Family, Pyrin Domain-Containing 3 Protein | 2022 |
Inhibition effect of choline and parecoxib sodium on chronic constriction nerve injury-induced neuropathic pain in rats.
Topics: Analgesics; Animals; Choline; Constriction; HMGB1 Protein; Hyperalgesia; Isoxazoles; Neuralgia; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2023 |