Page last updated: 2024-09-03

parecoxib and indomethacin

parecoxib has been researched along with indomethacin in 12 studies

Compound Research Comparison

Studies
(parecoxib)
Trials
(parecoxib)
Recent Studies (post-2010)
(parecoxib)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
43618622929,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyparecoxib (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (75.00)29.6817
2010's2 (16.67)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Engberg, G; Erhardt, C; Erhardt, S; Schwieler, L1
Engberg, G; Erhardt, S; Linderholm, K; Nilsson, L; Schwieler, L1
Hentunen, T; Kellinsalmi, M; Lehenkari, P; Lehtonen, S; Leskelä, HV; Parikka, V; Risteli, J; Selander, K; Väänänen, K1
Nylander, O; Pihl, L; Wilander, E1
Babis, GC; Korres, DS; Nikolopoulos, K; Soucacos, PN; Tsailas, PG1
Dimmen, S; Engebretsen, L; Madsen, JE; Nordsletten, L; Steen, H1
Dimmen, S; Engebretsen, L; Madsen, JE; Nordsletten, L1
Dimmen, S; Madsen, JE; Nordsletten, L1
Bosselmann, S; Chada, M; Gessner, A; Kandler, M; Nögel, SC; Rascher, W; Schmidt, AM; Schneider, H; Schweer, H; Watzer, B1
Dimmen, S1
Cebrián, C; Conde, B; Esquivias, P; Esteva, F; Jiménez, P; Lanas, A; Ortego, J; Piazuelo, E; Santander, S1
Geng, C; Li, X; Li, Y; Song, S; Wang, C1

Other Studies

12 other study(ies) available for parecoxib and indomethacin

ArticleYear
Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms.
    Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:7

    Topics: Animals; Brain; Diclofenac; Enzyme Inhibitors; Indomethacin; Isoxazoles; Kynurenic Acid; Male; Meloxicam; Prostaglandins; Protein Isoforms; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles

2005
Effects of COX-1 and COX-2 inhibitors on the firing of rat midbrain dopaminergic neurons--possible involvement of endogenous kynurenic acid.
    Synapse (New York, N.Y.), 2006, Volume: 59, Issue:5

    Topics: Action Potentials; Animals; Chromatography, High Pressure Liquid; Dopamine; Drug Interactions; Electrochemistry; Enzyme Inhibitors; Indomethacin; Isoxazoles; Kynurenic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Ventral Tegmental Area

2006
Inhibition of cyclooxygenase-2 down-regulates osteoclast and osteoblast differentiation and favours adipocyte formation in vitro.
    European journal of pharmacology, 2007, Oct-31, Volume: 572, Issue:2-3

    Topics: Adipocytes; Animals; Cattle; Cell Differentiation; Cell Lineage; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Indomethacin; Isoxazoles; Male; Mesenchymal Stem Cells; Mice; Nitrobenzenes; Osteoblasts; Osteoclasts; Rats; Rats, Sprague-Dawley; Sulfonamides

2007
Comparative study of the effect of luminal hypotonicity on mucosal permeability in rat upper gastrointestinal tract.
    Acta physiologica (Oxford, England), 2008, Volume: 193, Issue:1

    Topics: Animals; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Duodenum; Gastric Mucosa; Hydrogen-Ion Concentration; Hypotonic Solutions; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Inulin; Isoxazoles; Jejunum; Male; Methylglucosides; Osmolar Concentration; Permeability; Rats; Rats, Inbred Strains; Sodium Chloride; Stomach; Upper Gastrointestinal Tract; Urea

2008
The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits.
    The Journal of surgical research, 2009, Volume: 151, Issue:1

    Topics: Animals; Bone and Bones; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indomethacin; Injections, Subcutaneous; Isoxazoles; Male; Meloxicam; Ossification, Heterotopic; Osteogenesis; Rabbits; Radiography; Thiazines; Thiazoles

2009
The effect of parecoxib and indometacin on tendon-to-bone healing in a bone tunnel: an experimental study in rats.
    The Journal of bone and joint surgery. British volume, 2009, Volume: 91, Issue:2

    Topics: Animals; Anterior Cruciate Ligament; Biomechanical Phenomena; Bone Density; Cyclooxygenase Inhibitors; Female; Indomethacin; Isoxazoles; Random Allocation; Rats; Rats, Wistar; Stress, Mechanical; Tendons; Wound Healing

2009
Negative effects of parecoxib and indomethacin on tendon healing: an experimental study in rats.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2009, Volume: 17, Issue:7

    Topics: Animals; Cyclooxygenase Inhibitors; Female; Indomethacin; Isoxazoles; Random Allocation; Rats; Rats, Wistar; Recovery of Function; Tendons; Tensile Strength; Treatment Outcome; Wound Healing

2009
Parecoxib and indomethacin delay early fracture healing: a study in rats.
    Clinical orthopaedics and related research, 2009, Volume: 467, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Female; Fracture Healing; Indomethacin; Isoxazoles; Rats; Rats, Wistar; Time Factors

2009
Parecoxib does not suppress thromboxane synthesis in newborn piglets with group B streptococcal sepsis.
    Prostaglandins & other lipid mediators, 2009, Volume: 90, Issue:1-2

    Topics: Animals; Animals, Newborn; Cyclooxygenase 2 Inhibitors; Dinoprostone; Epoprostenol; Gene Expression Regulation; Hemodynamics; Indomethacin; Inflammation; Isoxazoles; Lung; Platelet Count; Receptors, Prostaglandin E; Sepsis; Streptococcal Infections; Streptococcus agalactiae; Swine; Thromboxanes

2009
Effects of Cox inhibitors on bone and tendon healing.
    Acta orthopaedica. Supplementum, 2011, Volume: 82, Issue:342

    Topics: Animals; Biomechanical Phenomena; Bone Density; Cyclooxygenase Inhibitors; Female; Fracture Healing; Fractures, Bone; Indomethacin; Isoxazoles; Models, Animal; Pain, Postoperative; Rats; Rats, Wistar; Tendon Injuries; Treatment Outcome; Wound Healing

2011
Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice.
    International journal of oncology, 2012, Volume: 40, Issue:2

    Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Esophageal Neoplasms; Female; Gene Expression; Humans; Indomethacin; Isoxazoles; Male; Mice; Mice, Nude; Random Allocation; Receptors, Prostaglandin E; Tumor Burden; Xenograft Model Antitumor Assays

2012
Nonsteroidal anti-inflammatory drugs alleviate severity of post-endoscopic retrograde cholangiopancreatography pancreatitis by inhibiting inflammation and reducing apoptosis.
    Journal of gastroenterology and hepatology, 2020, Volume: 35, Issue:5

    Topics: Acinar Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cholangiopancreatography, Endoscopic Retrograde; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Gene Expression; Indomethacin; Isoxazoles; Pancreatitis; Rats; Rats, Sprague-Dawley; Severity of Illness Index

2020