parecoxib has been researched along with dinoprostone in 14 studies
| Studies (parecoxib) | Trials (parecoxib) | Recent Studies (post-2010) (parecoxib) | Studies (dinoprostone) | Trials (dinoprostone) | Recent Studies (post-2010) (dinoprostone) |
|---|---|---|---|---|---|
| 436 | 186 | 229 | 29,105 | 1,346 | 6,357 |
| Protein | Taxonomy | parecoxib (IC50) | dinoprostone (IC50) |
|---|---|---|---|
| Prostaglandin E2 receptor EP1 subtype | Homo sapiens (human) | 0.0155 | |
| Prostaglandin E2 receptor EP4 subtype | Homo sapiens (human) | 0.0031 | |
| Prostaglandin E2 receptor EP4 subtype | Rattus norvegicus (Norway rat) | 0.0021 | |
| Prostaglandin E2 receptor EP3 subtype | Homo sapiens (human) | 0.002 | |
| Prostaglandin E2 receptor EP2 subtype | Homo sapiens (human) | 0.0087 | |
| Prostacyclin receptor | Homo sapiens (human) | 0.26 | |
| Prostaglandin E2 receptor EP2 subtype | Rattus norvegicus (Norway rat) | 0.0052 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Bloemendaal, AL; Borel Rinkes, IH; Kranenburg, O; Smakman, N; van Diest, P; Vogten, JM | 1 |
| Djurhuus, JC; Frøkiaer, J; Jensen, BL; Nielsen, SS; Nørregaard, R; Topcu, SO; Walter, S | 1 |
| Candelario-Jalil, E; Fiebich, BL; Koch, FW; Seidel, MF; Ulrich-Merzenich, G; Vetter, H | 1 |
| Bucher, M; Höcherl, K; Schmidt, C | 1 |
| Blomqvist, A; Elander, L; Engström, L; Hamzic, N; Lönn, J; Nilsberth, C; Norell, M | 1 |
| Bosselmann, S; Chada, M; Gessner, A; Kandler, M; Nögel, SC; Rascher, W; Schmidt, AM; Schneider, H; Schweer, H; Watzer, B | 1 |
| Chen, L; Geng, D; Huang, C; Mao, H; Wang, J; Xu, Y; Yang, H; Zhu, X | 1 |
| Cebrián, C; Conde, B; Esquivias, P; Esteva, F; Jiménez, P; Lanas, A; Ortego, J; Piazuelo, E; Santander, S | 1 |
| Chen, C; Peng, M; Wang, CY; Wang, FF; Wang, YL | 1 |
| Wang, S; Wu, H; Wu, Y; Zhu, Y | 1 |
| Darabi, A; Eberstål, S; Fritzell, S; Sandén, E; Siesjö, P; Visse, E | 1 |
| Chen, G; Li, X; Li, Y; Liang, H; Ouyang, W; Tong, J; Wu, Y; Zhou, L | 1 |
| Brack, A; Broscheit, JA; Rittner, HL; Roewer, N; Sauer, RS; Shityakov, S; Sohajda, T | 1 |
| Cui, R; Ji, X; Kang, Y; Shi, G; Wang, Y; Yan, H; Zhang, G; Zhang, T; Zhao, H | 1 |
2 trial(s) available for parecoxib and dinoprostone
| Article | Year |
|---|---|
Effect of perioperative parecoxib on postoperative pain and local inflammation factors PGE2 and IL-6 for total knee arthroplasty: a randomized, double-blind, placebo-controlled study.
Topics: Aged; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Cyclooxygenase 2 Inhibitors; Dinoprostone; Double-Blind Method; Female; Humans; Inflammation; Interleukin-6; Isoxazoles; Knee Joint; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Postoperative Nausea and Vomiting; Range of Motion, Articular; Synovial Fluid | 2014 |
Propranolol Attenuates Surgical Stress-Induced Elevation of the Regulatory T Cell Response in Patients Undergoing Radical Mastectomy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Breast Neoplasms; Catecholamines; Cell Proliferation; Cells, Cultured; Dinoprostone; Epinephrine; Female; Forkhead Transcription Factors; Humans; Immune Tolerance; Inflammation; Interferon-gamma; Isoxazoles; Leukocytes, Mononuclear; Lymphocyte Count; Mastectomy, Radical; Middle Aged; Norepinephrine; Propranolol; RNA, Messenger; Stress, Physiological; T-Lymphocytes, Regulatory | 2016 |
12 other study(ies) available for parecoxib and dinoprostone
| Article | Year |
|---|---|
Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Genes, ras; Image Processing, Computer-Assisted; Immunohistochemistry; Isoxazoles; Ki-67 Antigen; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Microcirculation; Mutation; Neoplasm Metastasis; Neoplasm Transplantation; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins p21(ras); RNA Interference; Time Factors | 2005 |
Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Humans; Isoxazoles; Male; Membrane Proteins; Pelvis; Pressure; Rats; Rats, Wistar; Receptors, Prostaglandin; RNA, Messenger; Ureter; Ureteral Obstruction | 2006 |
Serotonin mediates PGE2 overexpression through 5-HT2A and 5-HT3 receptor subtypes in serum-free tissue culture of macrophage-like synovial cells.
Topics: Aged; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Humans; Indoles; Interleukin-1beta; Isoxazoles; Ketanserin; Leukotriene B4; Macrophages; Middle Aged; Osteoarthritis; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin, 5-HT3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Serotonin Agents; Serotonin Antagonists; Synovial Membrane; Tropisetron; Tumor Necrosis Factor-alpha | 2008 |
COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex.
Topics: Acute Disease; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Isoxazoles; Kidney Cortex; Kidney Diseases; Lipopolysaccharides; Male; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Rats; Rats, Sprague-Dawley | 2009 |
The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.
Topics: Animals; Body Temperature; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Fever; Genotype; Immunoassay; Immunohistochemistry; Interleukin-6; Isoxazoles; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Viscera | 2009 |
Parecoxib does not suppress thromboxane synthesis in newborn piglets with group B streptococcal sepsis.
Topics: Animals; Animals, Newborn; Cyclooxygenase 2 Inhibitors; Dinoprostone; Epoprostenol; Gene Expression Regulation; Hemodynamics; Indomethacin; Inflammation; Isoxazoles; Lung; Platelet Count; Receptors, Prostaglandin E; Sepsis; Streptococcal Infections; Streptococcus agalactiae; Swine; Thromboxanes | 2009 |
Protective effects of COX-2 inhibitor on titanium-particle-induced inflammatory osteolysis via the down-regulation of RANK/RANKL.
Topics: Acid Phosphatase; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Immunohistochemistry; Interleukin-1beta; Isoenzymes; Isoxazoles; Membranes; Mice; Mice, Inbred BALB C; Osteoclasts; Osteogenesis; Osteolysis; Particulate Matter; Protective Agents; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Tartrate-Resistant Acid Phosphatase; Titanium; Tumor Necrosis Factor-alpha | 2011 |
Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice.
Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Esophageal Neoplasms; Female; Gene Expression; Humans; Indomethacin; Isoxazoles; Male; Mice; Mice, Nude; Random Allocation; Receptors, Prostaglandin E; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
The cyclooxygenase-2 inhibitor parecoxib inhibits surgery-induced proinflammatory cytokine expression in the hippocampus in aged rats.
Topics: Aging; Animals; Cognition Disorders; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Encephalitis; Gene Expression; Hippocampus; Interleukin-1beta; Isoxazoles; Male; Postoperative Complications; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2012 |
Intratumoral COX-2 inhibition enhances GM-CSF immunotherapy against established mouse GL261 brain tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drug Synergism; Female; Flow Cytometry; Glioma; Granulocyte-Macrophage Colony-Stimulating Factor; Immunoenzyme Techniques; Immunotherapy; Intramolecular Oxidoreductases; Isoxazoles; Mice; Mice, Inbred C57BL; Prostaglandin-E Synthases; Sulfonamides; Tumor Cells, Cultured | 2014 |
A Novel Approach for the Control of Inflammatory Pain: Prostaglandin E2 Complexation by Randomly Methylated β-Cyclodextrins.
Topics: Animals; beta-Cyclodextrins; Computer Simulation; Cyclooxygenase 2 Inhibitors; Dinoprostone; Electrophoresis, Capillary; Hyperalgesia; Inflammation; Inflammation Mediators; Isoxazoles; Male; Methylation; Pain; Pain Measurement; Pain Threshold; Postural Balance; Rats; Rats, Wistar | 2017 |
Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition.
Topics: Aging; Animals; Calcium-Binding Proteins; Cyclooxygenase 2; Cytokines; Dinoprostone; Dopamine Plasma Membrane Transport Proteins; Isoxazoles; Male; Microfilament Proteins; Microglia; Mitochondria; Mitochondrial Proteins; Motor Activity; Organelle Biogenesis; Protein Kinases; Rats; Rats, Sprague-Dawley; Substantia Nigra; Superoxide Dismutase; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases | 2021 |