Page last updated: 2024-09-03

parecoxib and diclofenac

parecoxib has been researched along with diclofenac in 14 studies

Compound Research Comparison

Studies
(parecoxib)
Trials
(parecoxib)
Recent Studies (post-2010)
(parecoxib)
Studies
(diclofenac)
Trials
(diclofenac)
Recent Studies (post-2010) (diclofenac)
4361862298,8741,8743,616

Protein Interaction Comparison

ProteinTaxonomyparecoxib (IC50)diclofenac (IC50)
Aldo-keto reductase family 1 member B10Homo sapiens (human)1.9
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.003
Prostaglandin G/H synthase 1Ovis aries (sheep)1.3376
Interleukin-8Homo sapiens (human)0.008
Prostaglandin G/H synthase 1Homo sapiens (human)0.0415
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.5
C-X-C chemokine receptor type 1Homo sapiens (human)0.012
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.5
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.5
Prostaglandin G/H synthase 2Homo sapiens (human)0.4165
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.5
Prostaglandin G/H synthase 2Ovis aries (sheep)1.6867
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.0502
Solute carrier family 22 member 6Homo sapiens (human)4
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.02

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (50.00)29.6817
2010's6 (42.86)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Frölich, JC; Stichtenoth, DO1
Burian, M; Geisslinger, G1
Engberg, G; Erhardt, C; Erhardt, S; Schwieler, L1
Meechan, J1
Abdalla, H; Buckley, E; Butler, M; Iohom, G; Larney, V; O'Brien, J; Shorten, GD; Szarvas, S1
Deray, G; Montalescot, G; Sibilia, J1
Deusch, E; Duris, M; Gebhardt, K; Kozek-Langenecker, S; Scharbert, G; Sow, Z1
Elliott, WJ1
Fuskevåg, OM; Reikerås, O; Shegarfi, H; Utvåg, SE1
Alexandris, I; Athanasiou, K; Kyriakidis, AV; Mpesikos, I; Papadopoulos, Ch; Perysinakis, I1
Armstrong, PC; Emerson, M; Kirkby, NS; Mitchell, JA; Warner, TD; Zain, ZN1
Cai, WX; Kruse-Gujer, A; Lang, NP; Ma, L; Stübinger, S; Zheng, LW; Zwahlen, RA1
Balbontín-Ayala, F; Cañigral, A; Carlos, Fd; Cobo, T; Fernández-González, FJ; Fernández-Vázquez, JP; Gonzalo-Orden, JM; Sánchez-Lasheras, F; Vega, JA1
Ferguson, MC; McNicol, ED; Schumann, R1

Reviews

6 review(s) available for parecoxib and diclofenac

ArticleYear
The second generation of COX-2 inhibitors: what advantages do the newest offer?
    Drugs, 2003, Volume: 63, Issue:1

    Topics: Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Etoricoxib; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Organic Chemicals; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfonamides; Sulfones

2003
[Clinical pharmacology of the selective COX-2 inhibitors].
    Der Orthopade, 2003, Volume: 32, Issue:12

    Topics: Acute Disease; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Pain; Pain, Postoperative; Placebos; Pyrazoles; Sulfonamides; Sulfones

2003
[What do we know about the cardiovascular toxicity of the NSAIDs?].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:9 Spec No

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Case-Control Studies; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Follow-Up Studies; Humans; Isoxazoles; Lactones; Meta-Analysis as Topic; Middle Aged; Naproxen; Pyrazoles; Randomized Controlled Trials as Topic; Risk Factors; Sulfonamides; Sulfones; Thrombosis; Time Factors

2006
Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality?
    Current hypertension reports, 2010, Volume: 12, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Humans; Hypertension; Isoxazoles; Lactones; Pyrazoles; Pyridines; Risk; Risk Factors; Sulfonamides; Sulfones

2010
Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review.
    Dental press journal of orthodontics, 2015, Volume: 20, Issue:5

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Bone Remodeling; Celecoxib; Clodronic Acid; Diclofenac; Diphosphonates; Humans; Imidazoles; Interferon-gamma; Isoxazoles; Lactones; Mice; Orthodontic Anchorage Procedures; Osteoclasts; Osteoprotegerin; Pamidronate; Rats; Resveratrol; Stilbenes; Sulfones; Tooth Mobility; Tooth Movement Techniques; Zoledronic Acid

2015
Single-dose intravenous ketorolac for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2021, 05-17, Volume: 5

    Topics: Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bias; Diclofenac; Humans; Injections, Intravenous; Isoxazoles; Ketorolac; Middle Aged; Numbers Needed To Treat; Pain, Postoperative; Placebos; Randomized Controlled Trials as Topic; Time Factors; Young Adult

2021

Trials

4 trial(s) available for parecoxib and diclofenac

ArticleYear
COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003.
    The British journal of oral & maxillofacial surgery, 2006, Volume: 44, Issue:2

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Ibuprofen; Injections, Intravenous; Isoxazoles; Lactones; Pain, Postoperative; Preanesthetic Medication; Prodrugs; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction

2006
The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:4

    Topics: Acetaminophen; Adult; Aged; Analgesia; Anxiety; Breast Neoplasms; Bupivacaine; Celecoxib; Chronic Disease; Depression; Dextropropoxyphene; Diclofenac; Female; Humans; Isoxazoles; Mastectomy; Middle Aged; Morphine; Nerve Block; Nitric Oxide; Nociceptors; Pain Measurement; Pain, Postoperative; Pyrazoles; Sulfonamides

2006
Point-of-care platelet function tests: detection of platelet inhibition induced by nonopioid analgesic drugs.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2007, Volume: 18, Issue:8

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; False Positive Reactions; Female; Humans; Isoxazoles; Low Back Pain; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Point-of-Care Systems; Thrombelastography

2007
Parecoxib sodium in the treatment of postoperative pain after Lichtenstein tension-free mesh inguinal hernia repair.
    Hernia : the journal of hernias and abdominal wall surgery, 2011, Volume: 15, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclofenac; Double-Blind Method; Female; Hernia, Inguinal; Humans; Isoxazoles; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Piroxicam; Prospective Studies; Surgical Procedures, Operative

2011

Other Studies

4 other study(ies) available for parecoxib and diclofenac

ArticleYear
Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms.
    Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:7

    Topics: Animals; Brain; Diclofenac; Enzyme Inhibitors; Indomethacin; Isoxazoles; Kynurenic Acid; Male; Meloxicam; Prostaglandins; Protein Isoforms; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles

2005
Short-term treatment with COX-2 inhibitors does not impair fracture healing.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2010, Volume: 23, Issue:5

    Topics: Animals; Bone Density; Cyclooxygenase 2 Inhibitors; Diclofenac; Fracture Healing; Isoxazoles; Male; Rats; Rats, Wistar; Sulfonamides

2010
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse.
    PloS one, 2011, Volume: 6, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Thrombosis

2011
Influence of non-steroidal anti-inflammatory drugs (NSAIDs) on osseointegration of dental implants in rabbit calvaria.
    Clinical oral implants research, 2015, Volume: 26, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dental Implants; Diclofenac; Implants, Experimental; Isoxazoles; Osseointegration; Rabbits; Skull; X-Ray Microtomography

2015