parecoxib has been researched along with celecoxib in 30 studies
| Studies (parecoxib) | Trials (parecoxib) | Recent Studies (post-2010) (parecoxib) | Studies (celecoxib) | Trials (celecoxib) | Recent Studies (post-2010) (celecoxib) |
|---|---|---|---|---|---|
| 436 | 186 | 229 | 5,273 | 843 | 2,428 |
| Protein | Taxonomy | parecoxib (IC50) | celecoxib (IC50) |
|---|---|---|---|
| Chain A, Carbonic anhydrase II | Homo sapiens (human) | 0.021 | |
| Prostaglandin E synthase | Homo sapiens (human) | 0.4825 | |
| Histone deacetylase 3 | Homo sapiens (human) | 1.637 | |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | 7.9667 | |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | 0.057 | |
| Cytochrome c oxidase subunit 1 | Ovis aries (sheep) | 6.5 | |
| Cytochrome c oxidase subunit 2 | Ovis aries (sheep) | 0.0881 | |
| Catechol O-methyltransferase | Mus musculus (house mouse) | 0.036 | |
| Cytochrome c oxidase subunit 2 | Homo sapiens (human) | 0.371 | |
| Carbonic anhydrase 1 | Homo sapiens (human) | 0.1555 | |
| Carbonic anhydrase 2 | Homo sapiens (human) | 0.0925 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 5.271 | |
| Procathepsin L | Homo sapiens (human) | 0.56 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 7.308 | |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | 0.07 | |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | 4.295 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 1 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 10 | |
| Calpain-2 catalytic subunit | Homo sapiens (human) | 0.002 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 1.516 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.12 | |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | 3.6401 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 3.5499 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 7.308 | |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | 0.006 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 6.276 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.3818 | |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | 0.4028 | |
| Urotensin-2 receptor | Rattus norvegicus (Norway rat) | 7.6 | |
| Histone deacetylase 4 | Homo sapiens (human) | 1.637 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.03 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 0.6343 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 7.7 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 2.431 | |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | 0.045 | |
| Histone deacetylase 1 | Homo sapiens (human) | 1.411 | |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | 0.81 | |
| Carbonic anhydrase 9 | Homo sapiens (human) | 0.016 | |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | 0.05 | |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | 0.3 | |
| Prostaglandin G/H synthase 1 | Canis lupus familiaris (dog) | 5.57 | |
| Cyclooxygenase-2 | Canis lupus familiaris (dog) | 0.9 | |
| Histone deacetylase 7 | Homo sapiens (human) | 1.637 | |
| Histone deacetylase 2 | Homo sapiens (human) | 1.637 | |
| Carbonic anhydrase 4 | Bos taurus (cattle) | 0.2227 | |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | 1.637 | |
| Histone deacetylase 11 | Homo sapiens (human) | 1.637 | |
| Histone deacetylase 8 | Homo sapiens (human) | 1.637 | |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | 0.04 | |
| Histone deacetylase 6 | Homo sapiens (human) | 1.14 | |
| Histone deacetylase 9 | Homo sapiens (human) | 1.637 | |
| Histone deacetylase 5 | Homo sapiens (human) | 1.637 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (43.33) | 29.6817 |
| 2010's | 14 (46.67) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gilmer, JF; Kedziora, K; Kelleher, DP; Keogh, B; Maguire, J; Reilly, M; Ruiz, JF; Windle, H | 1 |
| Hardy, KJ; McMurray, RW | 1 |
| Rowbotham, DJ | 1 |
| Boehncke, WH; Gibbs, BF | 1 |
| Burian, M; Geisslinger, G | 1 |
| Møiniche, S; Rømsing, J | 1 |
| Benoit, V; de Leval, X; Dogné, JM; Frederich, M; Julémont, F; Pirotte, B | 1 |
| Furberg, CD; Psaty, BM | 1 |
| Drazen, JM | 1 |
| Meechan, J | 1 |
| Abdalla, H; Buckley, E; Butler, M; Iohom, G; Larney, V; O'Brien, J; Shorten, GD; Szarvas, S | 1 |
| Deray, G; Montalescot, G; Sibilia, J | 1 |
| Gajraj, NM | 1 |
| Arguelles, J; Cobo, J; Costales, M; de Carlos, F; Garcia, MA; Perillan, C; Vijande, M | 1 |
| Mateos, JL | 1 |
| Elliott, WJ | 1 |
| Intapan, T; Ittichaikulthol, W; Kositchaiwat, C; Prachanpanich, N | 1 |
| Dávila, I; González, A; Laffond, E; Moreno, E; Muñoz-Bellido, F; Ponce, V | 1 |
| Baber, C; McDonnell, NJ; Nathan, EA; Paech, MJ; Sinha, A | 1 |
| Li, J; Li, N; Peng, N; Yang, X | 1 |
| Balbontín-Ayala, F; Cañigral, A; Carlos, Fd; Cobo, T; Fernández-González, FJ; Fernández-Vázquez, JP; Gonzalo-Orden, JM; Sánchez-Lasheras, F; Vega, JA | 1 |
| Katchamart, W; Suwanawiboon, B; Tantayakom, P; Teerawattananon, C | 1 |
| Bian, Y; Feng, B; Jiang, J; Lin, J; Pei, F; Shen, B; Sun, T; Wang, W; Weng, X; Yan, S; Zhang, M; Zhuang, Q | 1 |
| Filippini-de Moor, GP; Steegers, MA; van Helmond, N; Vissers, KC; Wilder-Smith, OH | 1 |
| Cheng, L; Long, HT; Sun, BH; Zhao, SS; Zhu, Y | 1 |
| Cai, W; Fan, J; Tang, J; Yao, Y; Yin, G; Zhou, W | 1 |
| Pei, F; Shen, B; Si, H; Weng, X; Wu, Y; Yang, T; Zeng, Y | 1 |
| Bian, Y; Dong, Y; Fan, Y; Feng, B; Gao, N; Jin, J; Li, Y; Lin, J; Pei, F; Peng, H; Qian, W; Shen, B; Sun, T; Tao, L; Wang, W; Weng, X; Yan, S; Zhang, M; Zhuang, Q | 1 |
| Huang, L; Huang, Z; Jia, X; Liu, L; Ma, X; Tang, C; Wan, X; Wang, R; Zhang, M | 1 |
| Chaibhuddanugul, N; Laoruengthana, A; Malisorn, S; Pongpirul, K; Rattanaprichavej, P; Tangsripong, P | 1 |
11 review(s) available for parecoxib and celecoxib
| Article | Year |
|---|---|
Cox-2 inhibitors: today and tomorrow.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Etoricoxib; Humans; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Research; Sulfonamides; Sulfones | 2002 |
COX-2-selective inhibitors: clinical relevance in surgical and acute pain.
Topics: Acute Disease; Analgesics; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
[Clinical pharmacology of the selective COX-2 inhibitors].
Topics: Acute Disease; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Pain; Pain, Postoperative; Placebos; Pyrazoles; Sulfonamides; Sulfones | 2003 |
A systematic review of COX-2 inhibitors compared with traditional NSAIDs, or different COX-2 inhibitors for post-operative pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Lactones; Pain Measurement; Pain, Postoperative; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Sulfones; Treatment Outcome | 2004 |
First and second generations of COX-2 selective inhibitors.
Topics: Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etoricoxib; Gastrointestinal Diseases; Humans; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Sulfonamides; Sulfones | 2004 |
[What do we know about the cardiovascular toxicity of the NSAIDs?].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Case-Control Studies; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Follow-Up Studies; Humans; Isoxazoles; Lactones; Meta-Analysis as Topic; Middle Aged; Naproxen; Pyrazoles; Randomized Controlled Trials as Topic; Risk Factors; Sulfonamides; Sulfones; Thrombosis; Time Factors | 2006 |
COX-2 inhibitors celecoxib and parecoxib: valuable options for postoperative pain management.
Topics: Celecoxib; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Pain, Postoperative; Pyrazoles; Sulfonamides; Treatment Outcome | 2007 |
[Selective inhibitors of cyclooxygenase-2 (COX-2), celecoxib and parecoxib: a systematic review].
Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Administration Routes; Evidence-Based Medicine; Humans; Inflammation; Isoxazoles; Pain; Pain Measurement; Pyrazoles; Structure-Activity Relationship; Sulfonamides; Treatment Outcome | 2010 |
Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Humans; Hypertension; Isoxazoles; Lactones; Pyrazoles; Pyridines; Risk; Risk Factors; Sulfonamides; Sulfones | 2010 |
Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Bone Remodeling; Celecoxib; Clodronic Acid; Diclofenac; Diphosphonates; Humans; Imidazoles; Interferon-gamma; Isoxazoles; Lactones; Mice; Orthodontic Anchorage Procedures; Osteoclasts; Osteoprotegerin; Pamidronate; Rats; Resveratrol; Stilbenes; Sulfones; Tooth Mobility; Tooth Movement Techniques; Zoledronic Acid | 2015 |
Risk of perioperative bleeding related to highly selective cyclooxygenase-2 inhibitors: A systematic review and meta-analysis.
Topics: Blood Loss, Surgical; Celecoxib; Cyclooxygenase 2 Inhibitors; Etoricoxib; Humans; Isoxazoles; Postoperative Hemorrhage; Pyridines; Risk Factors; Sulfones | 2017 |
11 trial(s) available for parecoxib and celecoxib
| Article | Year |
|---|---|
COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Ibuprofen; Injections, Intravenous; Isoxazoles; Lactones; Pain, Postoperative; Preanesthetic Medication; Prodrugs; Pyrazoles; Sulfonamides; Sulfones; Tooth Extraction | 2006 |
The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery.
Topics: Acetaminophen; Adult; Aged; Analgesia; Anxiety; Breast Neoplasms; Bupivacaine; Celecoxib; Chronic Disease; Depression; Dextropropoxyphene; Diclofenac; Female; Humans; Isoxazoles; Mastectomy; Middle Aged; Morphine; Nerve Block; Nitric Oxide; Nociceptors; Pain Measurement; Pain, Postoperative; Pyrazoles; Sulfonamides | 2006 |
The post-operative analgesic efficacy of celecoxib compared with placebo and parecoxib after total hip or knee arthroplasty.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesia; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Celecoxib; Cyclooxygenase Inhibitors; Female; Humans; Isoxazoles; Male; Middle Aged; Pain, Postoperative; Postoperative Period; Pyrazoles; Sulfonamides; Treatment Outcome; Young Adult | 2010 |
A randomised controlled trial of parecoxib, celecoxib and paracetamol as adjuncts to patient-controlled epidural analgesia after caesarean delivery.
Topics: Acetaminophen; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Celecoxib; Cesarean Section; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Pregnancy; Pyrazoles; Sulfonamides | 2014 |
Effect of cyclooxygenase-2-specific inhibitors on postoperative analgesia after major open abdominal surgery.
Topics: Abdomen; Analgesia, Patient-Controlled; Analgesics, Opioid; Analysis of Variance; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Prospective Studies; Tramadol | 2015 |
Efficacy and safety of Postoperative Intravenous Parecoxib sodium Followed by ORal CElecoxib (PIPFORCE) post-total knee arthroplasty in patients with osteoarthritis: a study protocol for a multicentre, double-blind, parallel-group trial.
Topics: Administration, Oral; Arthroplasty, Replacement, Knee; Celecoxib; China; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Therapy, Combination; Humans; Injections, Intravenous; Isoxazoles; Osteoarthritis; Pain, Postoperative; Postoperative Care; Research Design; Treatment Outcome | 2016 |
Hyperalgesia and Persistent Pain after Breast Cancer Surgery: A Prospective Randomized Controlled Trial with Perioperative COX-2 Inhibition.
Topics: Adult; Aged; Breast Neoplasms; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Hyperalgesia; Isoxazoles; Mastectomy; Mastectomy, Segmental; Middle Aged; Pain Measurement; Pain Threshold; Pain, Postoperative; Perioperative Period; Prospective Studies; Quality of Life; Surveys and Questionnaires; Treatment Outcome | 2016 |
Application of a buprenorphine transdermal patch for the perioperative analgesia in patients who underwent simple lumbar discectomy.
Topics: Administration, Cutaneous; Administration, Intravenous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Celecoxib; Cyclooxygenase 2 Inhibitors; Diskectomy; Female; Humans; Isoxazoles; Lumbar Vertebrae; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Perioperative Care; Tramadol; Transdermal Patch; Treatment Outcome | 2017 |
[EFFICACY OF SEQUENTIAL TREATMENT WITH ADDUCTOR CANAL NERVE BLOCK AND CYCLOOXYGENASE 2 SELECTIVE INHIBITOR AFTER TOTAL KNEE ARTHROPLASTY].
Topics: Analgesics, Opioid; Arthroplasty, Replacement, Knee; Celecoxib; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Knee Joint; Morphine; Nerve Block; Operative Time; Osteoarthritis; Pain, Postoperative; Postoperative Period; Range of Motion, Articular; Treatment Outcome | 2016 |
Postoperative intravenous parecoxib sodium followed by oral celecoxib post total knee arthroplasty in osteoarthritis patients (PIPFORCE): a multicentre, double-blind, randomised, placebo-controlled trial.
Topics: Administration, Intravenous; Administration, Oral; Aged; Arthroplasty, Replacement, Knee; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Osteoarthritis, Knee; Pain, Postoperative; Postoperative Care; Retrospective Studies; Treatment Outcome | 2020 |
Prevention of Severe Acute Pancreatitis With Cyclooxygenase-2 Inhibitors: A Randomized Controlled Clinical Trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Pancreatitis; Prospective Studies; Severity of Illness Index; Treatment Outcome; Young Adult | 2020 |
8 other study(ies) available for parecoxib and celecoxib
| Article | Year |
|---|---|
A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors.
Topics: Animals; Benzenesulfonamides; Caco-2 Cells; Celecoxib; Clostridium perfringens; Colon; Colonic Neoplasms; Cyclization; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; NADH, NADPH Oxidoreductases; Nitroreductases; Prodrugs; Pyrazoles; Rats; Sulfonamides | 2011 |
Effects of rofecoxib, celecoxib, and parecoxib on anti-IgE-induced histamine release from human skin mast cells and basophils.
Topics: Antibodies, Anti-Idiotypic; Basophils; Celecoxib; Cyclooxygenase Inhibitors; Histamine Release; Humans; Isoxazoles; Lactones; Mast Cells; Pyrazoles; Skin; Sulfonamides; Sulfones | 2003 |
COX-2 inhibitors--lessons in drug safety.
Topics: Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Approval; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Publishing; Pyrazoles; Randomized Controlled Trials as Topic; Research Design; Sulfonamides; Sulfones; United States; United States Food and Drug Administration | 2005 |
COX-2 inhibitors--a lesson in unexpected problems.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Approval; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones | 2005 |
Orthodontic tooth movement after different coxib therapies.
Topics: Alveolar Process; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cephalometry; Cyclooxygenase 2 Inhibitors; Gingiva; Isoxazoles; Lactones; Male; Molar; Orthodontic Wires; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Sulfones; Time Factors; Tooth Movement Techniques | 2007 |
Fixed drug eruption caused by etoricoxib with tolerance to celecoxib and parecoxib.
Topics: Aged; Arm; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Eruptions; Etoricoxib; Female; Humans; Isoxazoles; Leg Dermatoses; Low Back Pain; Patch Tests; Pyrazoles; Pyridines; Sulfonamides; Sulfones | 2012 |
The efficacy of a multimodal analgesia protocol in preventing heterotopic ossification after acetabular fractures surgery.
Topics: Acetabulum; Adult; Aged; Analgesia; Celecoxib; Combined Modality Therapy; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Fractures, Bone; Humans; Isoxazoles; Male; Middle Aged; Ossification, Heterotopic; Pain Management; Pain, Postoperative; Retrospective Studies; Treatment Outcome; Young Adult | 2017 |
Perioperative Outcomes of Patients Who Were Not Candidates for Additional Nonsteroidal Anti-inflammatory Drugs in a Multimodal Pain Control Regimen for Total Knee Arthroplasty.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Knee; Celecoxib; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Retrospective Studies | 2021 |