paraquat has been researched along with alpha-synuclein in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (26.53) | 29.6817 |
| 2010's | 25 (51.02) | 24.3611 |
| 2020's | 11 (22.45) | 2.80 |
| Authors | Studies |
|---|---|
| Fink, AL; Li, J; Uversky, VN | 1 |
| Di Monte, DA; Fink, AL; Li, J; Manning-Bog, AB; McCormack, AL; Uversky, VN | 1 |
| Bolin, LM; Di Monte, DA; Manning-Bog, AB; McCormack, AL; Purisai, MG | 1 |
| Di Monte, DA; Doniach, S; Fink, AL; Goers, J; Manning-Bog, AB; McCormack, AL; Millett, IS; Uversky, VN | 1 |
| Di Monte, DA | 1 |
| Cooper, JM; Korlipara, LV; Messmer, K; Orth, M; Schapira, AH; Tabrizi, SJ; Tomlinson, C | 1 |
| Alfonso, A; Burnam, L; Hoener, M; Liu, L; Perier, C; Przedborski, S; Rodrigues, CM; Saha, S; Sluder, A; Steer, C; Ved, R; Westlund, B; Wolozin, B | 1 |
| Chen, SD; Du, YL; Liu, ZG; Lu, GQ | 1 |
| An, JJ; Cho, SW; Choi, HS; Choi, JH; Choi, SY; Eum, WS; Hwang, SI; Kang, JH; Kang, TC; Kim, DW; Kim, SY; Kwon, HJ; Kwon, OS; Lee, SH; Park, J; Won, MH; Yoo, KY | 1 |
| An, JJ; Cho, SW; Choi, HS; Choi, SY; Eum, WS; Kang, JH; Kang, TC; Kim, DW; Kim, SY; Kwon, HJ; Kwon, OS; Lee, SH; Park, J; Won, MH; Yoo, KY | 1 |
| Giasson, BI; Lee, VM; Leight, S; Norris, EH; Trojanowski, JQ; Uryu, K | 1 |
| Chesselet, MF; Fernagut, PO; Fleming, SM; Hutson, CB; Masliah, E; Salcedo, J; Tetreaut, NA | 1 |
| Chau, KY; Cooper, JM; Korlipara, LV; Schapira, AH | 1 |
| Cuervo, AM; Di Monte, DA; Mak, SK; Manning-Bog, AB; McCormack, AL | 1 |
| Chau, KY; Cooper, JM; Schapira, AH | 1 |
| Bronstein, J; Cockburn, M; Farrer, M; Gatto, NM; Manthripragada, AD; Rhodes, SL; Ritz, B | 1 |
| Andersen, JK; Oo, ML; Peng, J | 1 |
| Feng, LR; Maguire-Zeiss, KA | 1 |
| Bhattacharyya, A; Chakrabarti, N; Mitra, S | 1 |
| Armentero, MT; Blandini, F | 1 |
| Credle, J; Duka, V; Jones, J; Lee, JH; Oaks, AW; Sidhu, A; Wills, J | 1 |
| Desplats, P; Fujita, M; Hashimoto, M; Kosberg, K; Mante, M; Masliah, E; Patel, P; Patrick, C; Rockenstein, E | 1 |
| Andrieu, T; Baron, T; Bétemps, D; Chorfa, A; Hogeveen, K; Lazizzera, C; Morignat, E | 1 |
| Lenaers, G; Reynier, P; Thany, SH | 1 |
| Langston, JW; Mak, SK; Schüle, B; Tetrud, JW; Tewari, D | 1 |
| Akhtar, MW; Ambasudhan, R; Andreyev, AY; Chan, SF; Dolatabadi, N; Han, X; Jaenisch, R; Lee, B; Lipton, SA; Lopez, K; Masliah, E; Molokanova, E; Nagar, S; Nakamura, T; Nakanishi, N; Nutter, A; Okamoto, S; Parker, J; Ryan, SD; Shan, B; Soldner, F; Sunico, CR; Talantova, M; Yates, JR; Zhang, X; Zhang, Y | 1 |
| Ettle, B; Fields, J; Kosberg, K; Mante, M; Masliah, E; Nuber, S; Overk, CR; Rockenstein, E; Tadros, D; Trejo, M | 1 |
| de Souza, TL; Follmer, C; Maturana, MG; Pinheiro, AS | 1 |
| Corbett, J; Kadiiska, MB; Kumar, A; Leinisch, F; Mason, RP | 1 |
| Anandhan, A; Bohovych, I; Bradley, E; de Jong, A; Franco, R; Khalimonchuk, O; Navarro-Yepes, J; Ovaa, H; Quintanilla-Vega, B; Yarabe, B; Zhou, Y | 1 |
| Candeletti, S; Caputi, FF; Carretta, D; Lattanzio, F; Palmisano, M; Romualdi, P | 1 |
| Anandhan, A; Cerny, RL; Franco, R; Khalimonchuk, O; Lei, S; Levytskyy, R; Panayiotidis, MI; Pappa, A; Powers, R | 1 |
| Ganini, D; Kumar, A; Mason, RP | 1 |
| Bradshaw, PC; Chaput, D; Cruz, J; Cvitkovic, E; Delic, V; Dinh, VB; Frederic, E; Gong, H; Griffin, JWD; Jinwal, U; Lee, DC; Mirzaei, H; Phan, TA; Placides, D; Reynes, C; Stevens, SM; Zhang, Y; Zivkovic, S | 1 |
| Morshedi, D; Pan-Montojo, F; Radjabian, T; Ruf, V; Sashourpour, M; Zahri, S | 1 |
| Antier, E; Baron, T; Bencsik, A; Gaillard, D; Lakhdar, L; Morignat, E; Naudet, N | 1 |
| Che, Y; Hou, L; Li, H; Liu, X; Piao, F; Sun, F; Wang, Q; Zhang, C; Zhang, D | 1 |
| Aboutalebi, H; Bae, EJ; Di Monte, DA; Helwig, M; Lee, SJ; Musgrove, RE; Ulusoy, A | 1 |
| Chen, RJ; Day, CH; Ho, TJ; Huang, CY; Ju, DT; Kuo, WW; Liao, PH; Shibu, MA; Sivalingam, K; Viswanadha, VP | 1 |
| Kuter, KZ; Ossowska, K; Śmiałowska, M | 1 |
| Arsac, JN; Baron, T; Dartiguelongue, M; Davoust, N; Mollereau, B; Sedru, M; Vulin, J | 1 |
| Huang, M; Tian, T; Wang, K; Wu, K; Yan, W; Zhang, B | 1 |
| Dai, L; Du, Z; Fang, Y; Jiang, H; Li, F; Li, H; Liu, C; Liu, Z; Meng, L; Tian, Y; Wang, Z; Xiong, M; Yan, Z; Yu, T; Yuan, X; Zhang, J; Zhang, Z | 1 |
| Cheng, Y; Deng, P; Duan, W; Fu, G; He, H; Hong, H; Lin, X; Lu, Y; Mao, G; Pi, H; Tong, T; Wang, X; Xu, J; Xu, S; Xu, Y; Yang, L; Yu, Z; Zhang, J; Zhou, Z | 1 |
| Anantharam, V; Bargues-Carot, A; Huang, M; Jin, H; Kanthasamy, A; Kanthasamy, AG; Riaz, Z; Wickham, H; Zenitsky, G | 1 |
| Cai, Q; Huang, M; Li, G; Shi, G; Wang, K; Zhang, B; Zhang, C | 1 |
| Chovsepian, A; Dening, Y; Dieterich, M; Dirscherl, P; Falkai, P; Giese, A; Giesert, F; Herms, J; Khairnar, A; Levin, J; Pan-Montojo, F; Ruf, V; Schmidt, F; Stievenard, A; Straßl, T; Weisenhorn, DV; Wurst, W | 1 |
| Nuber, S; Selkoe, DJ | 1 |
| Chang, R; Hou, L; Huang, R; Liu, J; Ruan, Z; Sun, F; Wang, Q; Wang, Y; Zhao, J | 1 |
3 review(s) available for paraquat and alpha-synuclein
| Article | Year |
|---|---|
The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?
Topics: alpha-Synuclein; Animals; Corpus Striatum; Environmental Exposure; Herbicides; Humans; Insecticides; Intracellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Neurotoxins; Oncogene Proteins; Paraquat; Parkinson Disease; Protein Deglycase DJ-1; Risk Factors; Rotenone; Synucleins; Twin Studies as Topic | 2003 |
Animal models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Dopamine Agents; Herbicides; Humans; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Sympatholytics | 2012 |
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; DDT; Dieldrin; Herbicides; Humans; Manganese; Mitochondria; Neuroinflammatory Diseases; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Pesticides; Risk Factors; Rotenone; Trichloroethanes; Vanadium | 2022 |
46 other study(ies) available for paraquat and alpha-synuclein
| Article | Year |
|---|---|
Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.
Topics: alpha-Synuclein; Circular Dichroism; Dieldrin; Ditiocarb; Nerve Tissue Proteins; Paraquat; Parkinson Disease; Pesticides; Protein Binding; Protein Conformation; Protein Folding; Rotenone; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins | 2001 |
The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein.
Topics: alpha-Synuclein; Animals; Herbicides; Mice; Nerve Tissue Proteins; Paraquat; Recombinant Proteins; Synucleins; Up-Regulation | 2002 |
Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration.
Topics: alpha-Synuclein; Animals; Cell Count; Cell Survival; HSP70 Heat-Shock Proteins; Humans; Macromolecular Substances; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Paraquat; Parkinsonian Disorders; Promoter Regions, Genetic; Silver Staining; Substantia Nigra; Synucleins; Tyrosine 3-Monooxygenase | 2003 |
Nuclear localization of alpha-synuclein and its interaction with histones.
Topics: alpha-Synuclein; Cell Nucleus; Cloning, Molecular; Escherichia coli; Gene Expression Regulation; Histones; Humans; Kinetics; Microscopy, Electron; Nerve Tissue Proteins; Paraquat; Protein Binding; Recombinant Proteins; Synucleins | 2003 |
G209A mutant alpha synuclein expression specifically enhances dopamine induced oxidative damage.
Topics: Aconitate Hydratase; Adrenergic Uptake Inhibitors; alpha-Synuclein; Blotting, Western; Cell Line; Cells, Cultured; Dopamine; Ecdysterone; Glutathione; Herbicides; Humans; Immunohistochemistry; Mutation; Nerve Tissue Proteins; Oxidative Stress; Paraquat; Reserpine; Synucleins | 2004 |
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
Topics: 3-Hydroxybutyric Acid; alpha-Synuclein; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antioxidants; Apoptosis; Benzoates; Benzothiazoles; Bile Acids and Salts; Caenorhabditis elegans; Cholagogues and Choleretics; Copper; Disease Models, Animal; Electron Transport Complex I; Gene Deletion; Gene Expression Regulation; Gene Library; Genetic Techniques; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Ions; Iron; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Neurons; Oncogene Proteins; Oxygen Consumption; Paraquat; Parkinson Disease; Polyenes; Probucol; Protein Deglycase DJ-1; Pyrazoles; Pyridazines; RNA, Small Interfering; Rotenone; Sequence Homology, Amino Acid; Sodium Azide; Taurochenodeoxycholic Acid; Thiazoles; Time Factors; Transgenes; Ubiquitin-Protein Ligases | 2005 |
[Effects of different doses of levodopa on paraquat-induced neurotoxicity: an experiment with mice].
Topics: alpha-Synuclein; Animals; Blood-Brain Barrier; Disease Models, Animal; Dose-Response Relationship, Drug; Levodopa; Male; Mice; Mice, Inbred C57BL; Neurons; Paraquat; Substantia Nigra; Tyrosine 3-Monooxygenase | 2005 |
Transduced Tat-alpha-synuclein protects against oxidative stress in vitro and in vivo.
Topics: alpha-Synuclein; Animals; Astrocytes; Cell Death; Cell Survival; Gene Products, tat; Genetic Vectors; HSP70 Heat-Shock Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Mutation; Nerve Degeneration; Neurons; Oxidative Stress; Paraquat; Parkinsonian Disorders; Protein Transport; Recombinant Fusion Proteins; Transduction, Genetic | 2006 |
PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model.
Topics: alpha-Synuclein; Animals; Astrocytes; Cells, Cultured; Disease Models, Animal; Dopamine Agents; Enzyme Stability; Gene Expression; HSP70 Heat-Shock Proteins; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Recombinant Fusion Proteins; Serine Endopeptidases; Superoxide Dismutase | 2006 |
Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model.
Topics: alpha-Synuclein; Animals; Brain; Drug Synergism; Environmental Exposure; Fungicides, Industrial; Humans; Inclusion Bodies; Maneb; Mice; Mice, Transgenic; Mitochondria; Mutation, Missense; Paraquat; Parkinson Disease | 2007 |
Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Gene Expression Regulation; Humans; Locus Coeruleus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurons; Neurotoxicity Syndromes; Paraquat; Psychomotor Performance; Substantia Nigra; Tyrosine 3-Monooxygenase | 2007 |
Protection against paraquat and A53T alpha-synuclein toxicity by cabergoline is partially mediated by dopamine receptors.
Topics: alpha-Synuclein; Analysis of Variance; Apoptosis; Blotting, Western; Cabergoline; Caspase 3; Cell Line; Enzyme Activation; Ergolines; Glutathione; Humans; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Lactate Dehydrogenases; Membrane Potential, Mitochondrial; Paraquat; Parkinsonian Disorders; Reactive Oxygen Species; Receptors, Dopamine D2 | 2009 |
Lysosomal degradation of alpha-synuclein in vivo.
Topics: alpha-Synuclein; Animals; Autophagy; Disease Models, Animal; Herbicides; HSC70 Heat-Shock Proteins; Humans; Lysosomal-Associated Membrane Protein 2; Lysosomes; Male; Mesencephalon; Mice; Mice, Transgenic; Neurons; Paraquat; Parkinson Disease | 2010 |
Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells.
Topics: alpha-Synuclein; Caspase 3; Cell Death; Cell Line; Cell Survival; Dopamine; Enzyme Activation; Free Radicals; Glutathione; Humans; Indans; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondrial Membranes; Neuroprotective Agents; Oxidative Stress; Paraquat; Reactive Oxygen Species | 2010 |
α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease.
Topics: Age of Onset; Aged; alpha-Synuclein; California; Causality; Comorbidity; Educational Status; Environmental Exposure; Female; Fungicides, Industrial; Herbicides; Humans; Male; Maneb; Paraquat; Parkinson Disease; Risk Assessment; Rural Health; Smoking | 2010 |
Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration.
Topics: Aging; alpha-Synuclein; Animals; Cell Line; Cells, Cultured; Disease Progression; Environmental Exposure; Humans; Iron; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Paraquat; Parkinson Disease; Rats; Risk Factors | 2010 |
Dopamine and paraquat enhance α-synuclein-induced alterations in membrane conductance.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Cell Line, Tumor; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Doxycycline; Drug Interactions; Gene Expression Regulation; Green Fluorescent Proteins; Heme Oxygenase-1; Herbicides; Humans; Levodopa; Membrane Potentials; Mice; Nerve Tissue Proteins; Neuroblastoma; Paraquat; Patch-Clamp Techniques; Permeability; Tetrazolium Salts; Thiazoles; Transfection; Tubulin; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2011 |
Differential regional expression patterns of α-synuclein, TNF-α, and IL-1β; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment.
Topics: alpha-Synuclein; alpha-Tocopherol; Animals; Antioxidants; Behavior, Animal; Catalase; DNA-Binding Proteins; Dopaminergic Neurons; Dose-Response Relationship, Drug; Frontal Lobe; Glutathione Transferase; Herbicides; Hippocampus; Humans; Interleukin-1beta; Male; Mice; Nerve Degeneration; Nerve Tissue Proteins; Nuclear Proteins; Paraquat; Random Allocation; Reactive Oxygen Species; Substantia Nigra; Superoxide Dismutase; Survival Rate; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2011 |
Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways.
Topics: alpha-Synuclein; Animals; Autophagy; Case-Control Studies; Corpus Striatum; Down-Regulation; Fungicides, Industrial; Herbicides; Humans; Male; Maneb; Mice; Mice, Inbred C57BL; Paraquat; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Signal Transduction; Tauopathies | 2012 |
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Gene Expression Regulation; Gene-Environment Interaction; Hippocampus; Humans; Immunohistochemistry; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Maneb; Mice; Mice, Transgenic; Neurogenesis; Paraquat; Parkinson Disease; Pesticides; Protein Serine-Threonine Kinases; Real-Time Polymerase Chain Reaction; Transcription, Genetic | 2012 |
Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.
Topics: alpha-Synuclein; Cell Death; Cell Line, Tumor; Cell Survival; Glycine; Glyphosate; Humans; Insecticides; Maneb; Melanoma; Neuroblastoma; Paraquat; Parkinson Disease; Rotenone; Transduction, Genetic | 2013 |
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
Topics: alpha-Synuclein; Alzheimer Disease; Animals; Genetic Predisposition to Disease; Humans; Insecticides; Mitochondria; Neurodegenerative Diseases; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Rotenone | 2013 |
Mitochondrial dysfunction in skin fibroblasts from a Parkinson's disease patient with an alpha-synuclein triplication.
Topics: Adenosine Triphosphate; Adult; alpha-Synuclein; Cells, Cultured; Electron Transport Complex I; Female; Fibroblasts; Gene Expression Regulation; Herbicides; Humans; Male; Membrane Potential, Mitochondrial; Middle Aged; Mitochondrial Diseases; Paraquat; Parkinson Disease; RNA, Messenger; RNA, Small Interfering; Skin | 2011 |
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.
Topics: alpha-Synuclein; Gene-Environment Interaction; Humans; Induced Pluripotent Stem Cells; MEF2 Transcription Factors; Mitochondria; Mutation; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Nitrogen Species; Substantia Nigra; Transcription Factors; Transcription, Genetic | 2013 |
Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Animals; Autophagy; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Female; Gene Expression Regulation; Humans; Male; Mice; Mice, Transgenic; Mutation; Neural Pathways; Neurotoxins; Olfactory Bulb; Paraquat | 2014 |
Unveiling the role of the pesticides paraquat and rotenone on α-synuclein fibrillation in vitro.
Topics: alpha-Synuclein; Animals; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Microscopy, Electron, Transmission; Nuclear Magnetic Resonance, Biomolecular; Paraquat; Pesticides; Protein Binding; Radioisotopes; Rotenone; Sodium Chloride; Up-Regulation | 2015 |
Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Cyclic N-Oxides; Disease Models, Animal; Dopaminergic Neurons; Injections, Intraperitoneal; Male; Maneb; Mesencephalon; Mice, Inbred C57BL; Microglia; Models, Biological; NADPH Oxidases; Nitric Oxide Synthase Type II; Paraquat; Parkinson Disease; Peroxynitrous Acid; Spin Labels; Substantia Nigra; Tyrosine 3-Monooxygenase | 2016 |
Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.
Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Autophagy; Cell Death; Cell Line, Tumor; Cell Membrane; Dimerization; Dopaminergic Neurons; Green Fluorescent Proteins; Humans; Mice, Inbred C57BL; Models, Biological; Oxidation-Reduction; Paraquat; Proteasome Endopeptidase Complex; Proteolysis; RNA, Messenger; Saccharomyces cerevisiae; Sequestosome-1 Protein; Transcription, Genetic; Ubiquitin; Ubiquitination | 2016 |
Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells.
Topics: alpha-Synuclein; ATPases Associated with Diverse Cellular Activities; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Insecticides; Maneb; Models, Biological; Neuroblastoma; Paraquat; Parkinson Disease, Secondary; Proteasome Endopeptidase Complex; Receptors, Opioid; Tyrosine 3-Monooxygenase | 2015 |
Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions.
Topics: Adenylate Kinase; alpha-Synuclein; Animals; Autophagy; Biological Transport; Brain; Cell Death; Cell Line; Dopaminergic Neurons; Enzyme Activation; Gene-Environment Interaction; Glucose; Glucose Transport Proteins, Facilitative; Metabolome; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II; Paraquat; Pentose Phosphate Pathway; Rats; Signal Transduction | 2017 |
Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb- and paraquat-induced model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Cell Death; Cytochromes c; Free Radicals; Immunohistochemistry; Male; Maneb; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Neurons; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Paraquat; Parkinsonian Disorders; Pesticides | 2016 |
Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein.
Topics: Adenosine Triphosphate; alpha-Synuclein; Amino Acids; Cell Line, Tumor; Culture Media; Drug Evaluation, Preclinical; Energy Metabolism; Ferrous Compounds; Humans; Mitochondria; Neuroblastoma; Neurons; Oxidative Stress; Oxygen Consumption; Paraquat; Reactive Oxygen Species; Recombinant Proteins | 2017 |
A study on the modulation of alpha-synuclein fibrillation by Scutellaria pinnatifida extracts and its neuroprotective properties.
Topics: alpha-Synuclein; Animals; Cell Death; Dopaminergic Neurons; Flavonoids; Free Radical Scavengers; Humans; Microscopy, Fluorescence; Neuroprotective Agents; Paraquat; PC12 Cells; Plant Extracts; Plant Roots; Protein Multimerization; Rats; Scutellaria | 2017 |
Oral Exposure to Paraquat Triggers Earlier Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice.
Topics: Administration, Oral; alpha-Synuclein; Animals; Enteric Nervous System; Female; Gene Expression; Herbicides; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Paraquat; Phosphorylation | 2017 |
Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Dopaminergic Neurons; Gait; Gene Expression; Male; Maneb; Mice; Mice, Inbred C57BL; Microglia; NADPH Oxidase 2; NADPH Oxidases; Neuroprotective Agents; NF-kappa B; Paraquat; Parkinson Disease, Secondary; Signal Transduction; Taurine | 2018 |
Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer.
Topics: alpha-Synuclein; Animals; Axons; Brain; Cell Nucleus; Disease Progression; Humans; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidants; Oxidative Stress; Oxygen; Paraquat; Parkinson Disease; Reactive Oxygen Species; Vagus Nerve | 2019 |
Induction of Autophagy by Vasicinone Protects Neural Cells from Mitochondrial Dysfunction and Attenuates Paraquat-Mediated Parkinson's Disease Associated α-Synuclein Levels.
Topics: Alkaloids; alpha-Synuclein; Animals; Autophagy; Cells, Cultured; Justicia; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitophagy; Neuroprotective Agents; Paraquat; Parkinson Disease, Secondary; Phytotherapy; Protein Deglycase DJ-1; Protein Kinases; Reactive Oxygen Species; Ubiquitin-Protein Ligases | 2020 |
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.
Topics: alpha-Synuclein; Animals; Carrier Proteins; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Environmental Exposure; Herbicides; Inflammation; Lipopolysaccharides; Microglia; Nerve Tissue Proteins; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Protective Agents; Rats; Substantia Nigra | 2022 |
Chronic Exposure to Paraquat Induces Alpha-Synuclein Pathogenic Modifications in
Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dopaminergic Neurons; Drosophila; Herbicides; Male; Neurotoxins; Paraquat; Parkinson Disease | 2021 |
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.
Topics: alpha-Synuclein; Autophagy; Beclin-1; HMGB1 Protein; Humans; Paraquat; Parkinson Disease | 2022 |
Exposure to the environmentally toxic pesticide maneb induces Parkinson's disease-like neurotoxicity in mice: A combined proteomic and metabolomic analysis.
Topics: alpha-Synuclein; Animals; Environmental Pollutants; Fungicides, Industrial; Humans; Maneb; Metabolomics; Mice; Neuroblastoma; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Pesticides; Phenylalanine; Proteomics; Tryptophan | 2022 |
Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.
Topics: alpha-Synuclein; Animals; Ceramides; Cytokines; Environmental Pollutants; Glycerides; Glycerophospholipids; Herbicides; Humans; Lipopolysaccharides; Mesencephalon; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; Neurotoxicity Syndromes; Neurotoxins; Paraquat; Parkinson Disease; Parkinsonian Disorders; RNA, Messenger; Sphingolipids | 2022 |
Gut dysfunction may be the source of pathological aggregation of alpha-synuclein in the central nervous system through Paraquat exposure in mice.
Topics: alpha-Synuclein; Animals; Central Nervous System; Disease Models, Animal; Fatty Acids, Volatile; Intestinal Diseases; Mice; Mice, Inbred C57BL; Paraquat | 2022 |
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.
Topics: alpha-Synuclein; Animals; Dopaminergic Neurons; Mice; Paraquat; Parkinson Disease; Rotenone | 2022 |
The Parkinson-Associated Toxin Paraquat Shifts Physiological α-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers.
Topics: alpha-Synuclein; Animals; Calpain; Humans; Mice; Paraquat; Parkinson Disease | 2023 |
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase-NLRP3 inflammasome axis-dependent microglial activation.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Dopaminergic Neurons; Inflammasomes; Integrins; Macrophage-1 Antigen; Macrophages; Maneb; Memory Disorders; Mice; Microglia; NADPH Oxidases; NLR Family, Pyrin Domain-Containing 3 Protein; Paraquat; Parkinson Disease | 2023 |