Page last updated: 2024-08-21

paraquat and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

paraquat has been researched along with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19907 (20.00)18.7374
1990's5 (14.29)18.2507
2000's11 (31.43)29.6817
2010's11 (31.43)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Booth, RG; Caldera, P; Castagnoli, N; Johnson, EA; Lampen, P; Naiman, N; Rollema, H; Trevor, AJ; Youngster, SK1
Endo, T; Hara, S; Kano, S; Kuriiwa, F1
Chappey, O; Gallons, H; Houzé, P; Scherrmann, JM1
Bondy, SC; Lambert, CE1
Gee, SJ; Gietzen, DW; Hammock, BD; Magdalou, J; Woolley, DE1
Hassan, MN; Thakar, JH1
Cohen, P; Di Monte, D; Sandy, MS; Smith, MT1
Jones, K; Perry, TL; Wall, RA; Yong, VW1
Arora, PK; Blumer, JL; Frank, DM; Sayre, LM1
Barbeau, A; Buu, NT; Dallaire, L; Poirier, J; Rucinska, E1
Chen, TS; Koutsilieri, E; Rausch, WD1
Brooks, AI; Chadwick, CA; Cory-Slechta, DA; Federoff, HJ; Gelbard, HA1
Le Couteur, DG; McLean, AJ; Rivory, LP; Yang, MC1
Le Couteur, DG; McLean, AJ; Yang, MC1
Greenamyre, JT; Miller, GW; Quan, Y; Richardson, JR; Sherer, TB1
Donaire, V; Fuentes, JM; García, L; González-Polo, RA; Morán, JM; Niso, M; Soler, G1
Bové, J; Perier, C; Prou, D; Przedborski, S1
Ali, SF; Charlton, CG; Jiao, Y; Lamango, NS; Lee, ES; Oriaku, ET; Schmued, L; Shepherd, KR; Soliman, KF1
Kordower, JH; O'Malley, J; Soderstrom, K; Steece-Collier, K1
Cavada, C; Cuadrado, A; de Sagarra, MR; Rojo, AI1
Miller, GW1
James-Kracke, M; Miller, RL; Sun, AY; Sun, GY1
Barr, DB; Buckley, B; Montesano, MA; Richfield, EK; Thiruchelvam, M; Winnik, B1
Bové, J; Perier, C1
Armentero, MT; Blandini, F1
Dranka, BP; Kalyanaraman, B; Kanthasamy, AG; Zielonka, J1
Buckley, B1
Beck, M; Botham, PA; Breckenridge, CB; Butt, M; Cook, AR; Mathews, JM; Minnema, D; Smith, LL; Sturgess, NC; Tisdel, MO; Travis, KZ; Wolf, JC; Zadory, D1
Dixit, A; Mishra, M; Prakash, O; Singh, MP; Singh, PK; Srivastava, G; Verma, D1
Dagda, RK; Das Banerjee, T; Janda, E1
Armstrong, SM; Moore, C; Willis, GL1
Cao, X; Gao, T; Li, X; Lin, L; Liu, S; Luo, P; Qin, X; Sun, A; Wang, X; Wu, Q; Zhu, X1
Morrison, BE; Stojkovska, I; Wagner, BM1
Li, A; Lu, M; Wang, R; Wen, Y; Xu, J; Zhao, X; Zhou, J1
Anantharam, V; Bargues-Carot, A; Huang, M; Jin, H; Kanthasamy, A; Kanthasamy, AG; Riaz, Z; Wickham, H; Zenitsky, G1

Reviews

8 review(s) available for paraquat and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

ArticleYear
Toxin-induced models of Parkinson's disease.
    NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, 2005, Volume: 2, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine Agents; Herbicides; Humans; Neurotoxins; Oxidative Stress; Oxidopamine; Paraquat; Parkinson Disease, Secondary; Rotenone; Sympatholytics

2005
Neural repair strategies for Parkinson's disease: insights from primate models.
    Cell transplantation, 2006, Volume: 15, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Transplantation; Deep Brain Stimulation; Disease Models, Animal; Fungicides, Industrial; Glial Cell Line-Derived Neurotrophic Factor; Herbicides; Humans; Maneb; Nerve Degeneration; Oxidopamine; Paraquat; Parkinson Disease; Pesticides; Primates; Rotenone

2006
Oxidative and inflammatory pathways in Parkinson's disease.
    Neurochemical research, 2009, Volume: 34, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Herbicides; Humans; Inflammation; Lipopolysaccharides; Microglia; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neurotoxins; Nitric Oxide Synthase; Oxidative Stress; Oxidopamine; Paraquat; Parkinson Disease; Parkinsonian Disorders; Protein Kinase C; Rotenone

2009
Neurotoxin-based models of Parkinson's disease.
    Neuroscience, 2012, Jun-01, Volume: 211

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Cell Death; Disease Models, Animal; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease, Secondary; Rotenone

2012
Animal models of Parkinson's disease.
    The FEBS journal, 2012, Volume: 279, Issue:7

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Dopamine Agents; Herbicides; Humans; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Sympatholytics

2012
How Parkinsonian toxins dysregulate the autophagy machinery.
    International journal of molecular sciences, 2013, Nov-08, Volume: 14, Issue:11

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Autophagy; Humans; Methamphetamine; Mitophagy; MPTP Poisoning; Neurotoxins; Oxidopamine; Paraquat; Parkinsonian Disorders; Rotenone

2013
Parkinson's disease and enhanced inflammatory response.
    Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:11

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Inflammation; Lipopolysaccharides; Neurons; Oxidative Stress; Oxidopamine; Oxygen; Paraquat; Parkinson Disease; Ubiquitin-Protein Ligases

2015
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.
    International journal of molecular sciences, 2022, Sep-16, Volume: 23, Issue:18

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; DDT; Dieldrin; Herbicides; Humans; Manganese; Mitochondria; Neuroinflammatory Diseases; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Pesticides; Risk Factors; Rotenone; Trichloroethanes; Vanadium

2022

Other Studies

27 other study(ies) available for paraquat and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

ArticleYear
In vivo intracerebral microdialysis studies in rats of MPP+ analogues and related charged species.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Chemical Phenomena; Chemistry; Corpus Striatum; Dialysis; Dopamine; Kinetics; Lactates; Lactic Acid; Male; Molecular Structure; MPTP Poisoning; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1990
Effects of MPTP, MPP+, and paraquat on NADPH-dependent lipid peroxidation in mouse brain and lung microsomes.
    Biochemical medicine and metabolic biology, 1991, Volume: 45, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; In Vitro Techniques; Lipid Peroxidation; Lung; Male; Mice; Mice, Inbred ICR; Microsomes; NADPH-Ferrihemoprotein Reductase; Paraquat

1991
1-Methyl-4-phenylpyridinium (MPP+) does not exhibit paraquat-like immunoreactivity.
    Toxicology letters, 1990, Volume: 53, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Antibodies; Cross Reactions; Humans; Molecular Conformation; Paraquat; Radioimmunoassay

1990
Effects of MPTP, MPP+ and paraquat on mitochondrial potential and oxidative stress.
    Life sciences, 1989, Volume: 44, Issue:18

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Calcium; Cell Membrane; Intracellular Membranes; Kinetics; Lipid Peroxidation; Male; Membrane Potentials; Mitochondria; Neurotoxins; Paraquat; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred F344; Synaptosomes

1989
Does paraquat (PQ) mimic MPP+ toxicity?
    Proceedings of the Western Pharmacology Society, 1989, Volume: 32

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Male; Mice; Mice, Inbred C57BL; Paraquat; Pyridines; Pyridinium Compounds

1989
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), cyperquat (MPP+) and paraquat on isolated mitochondria from rat striatum, cortex and liver.
    Life sciences, 1988, Volume: 43, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Diphosphate; Animals; Cerebral Cortex; Corpus Striatum; Flavin-Adenine Dinucleotide; Malates; Mitochondria; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Paraquat; Phosphorylation; Pyridines; Pyridinium Compounds; Pyruvates; Pyruvic Acid; Rats; Succinates; Succinic Acid

1988
Role of active oxygen in paraquat and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) cytotoxicity.
    Basic life sciences, 1988, Volume: 49

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Carmustine; Cell Survival; Cells, Cultured; Deferoxamine; Free Radicals; Lipid Peroxidation; Liver; Paraquat; Phenylenediamines; Pyridines; Rats; Reference Values; Vitamin E

1988
Paraquat and two endogenous analogues of the neurotoxic substance N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine do not damage dopaminergic nigrostriatal neurons in the mouse.
    Neuroscience letters, 1986, Sep-12, Volume: 69, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Mice; Mice, Inbred C57BL; Neurons; Paraquat; Pyridines; Substantia Nigra

1986
Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a "redox cycling" mechanism in MPTP neurotoxicity.
    Biochemical and biophysical research communications, 1987, Sep-30, Volume: 147, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Cytochrome P-450 Enzyme System; Microsomes, Liver; NADP; Oxidation-Reduction; Paraquat; Pyridines; Pyridinium Compounds; Structure-Activity Relationship

1987
Comparative behavioral, biochemical and pigmentary effects of MPTP, MPP+ and paraquat in Rana pipiens.
    Life sciences, 1985, Oct-21, Volume: 37, Issue:16

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adrenal Medulla; Animals; Behavior, Animal; Brain Chemistry; Dopamine; Drug Interactions; Epinephrine; Melanophores; Motor Activity; Norepinephrine; Paraquat; Pargyline; Parkinson Disease, Secondary; Pigmentation; Posture; Pyridines; Pyridinium Compounds; Rana pipiens; Reflex

1985
MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/Bl6 mice.
    Journal of neural transmission. General section, 1995, Volume: 100, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Dopamine Agents; Homeostasis; Mesencephalon; Mice; Mice, Inbred C57BL; Paraquat

1995
Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss.
    Brain research, 1999, Mar-27, Volume: 823, Issue:1-2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Cell Death; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Herbicides; Male; Mice; Mice, Inbred C57BL; Nerve Endings; Nervous System; Neurons; Paraquat; Parkinson Disease, Secondary; Substantia Nigra; Synaptic Transmission

1999
Hepatic disposition of neurotoxins and pesticides.
    Pharmacology & toxicology, 2000, Volume: 87, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biological Transport; DDT; Hepatocytes; Humans; Liver; Malathion; Male; Neurotoxins; Paraquat; Parkinson Disease; Perfusion; Pesticides; Rats; Rats, Wistar; Tissue Distribution

2000
Age-related alteration in hepatic disposition of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and pesticides.
    Pharmacology & toxicology, 2002, Volume: 90, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; DDT; Dopamine Agents; Liver; Malathion; Male; Paraquat; Perfusion; Pesticides; Rats; Rats, Inbred F344

2002
Paraquat neurotoxicity is distinct from that of MPTP and rotenone.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 88, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Brain; Cell Line, Tumor; Dopamine Agents; Dose-Response Relationship, Drug; Herbicides; Humans; Insecticides; Mitochondria; Neuroblastoma; Neurons; Paraquat; Rotenone; Substrate Specificity

2005
Heat shock proteins protect both MPP(+) and paraquat neurotoxicity.
    Brain research bulletin, 2005, Nov-30, Volume: 67, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Blotting, Western; Cells, Cultured; Heat-Shock Proteins; Heat-Shock Response; Neurons; Neurotoxins; Paraquat; Quercetin; Rats

2005
The potentiating effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on paraquat-induced neurochemical and behavioral changes in mice.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 83, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Dopamine; Drug Synergism; Herbicides; Homovanillic Acid; Humans; Male; Methylation; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neurotoxins; Paraquat

2006
Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats.
    Experimental neurology, 2007, Volume: 208, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Administration, Inhalation; Administration, Intranasal; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Administration Schedule; Herbicides; Insecticides; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Degeneration; Neurons; Paraquat; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra

2007
Paraquat: the red herring of Parkinson's disease research.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 100, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Disease Models, Animal; Humans; Molecular Structure; Oxidative Stress; Paraquat; Parkinsonian Disorders; Reproducibility of Results; Structure-Activity Relationship

2007
Quantification of Paraquat, MPTP, and MPP+ in brain tissue using microwave-assisted solvent extraction (MASE) and high-performance liquid chromatography-mass spectrometry.
    Analytical and bioanalytical chemistry, 2009, Volume: 395, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine Agents; Estrogen Receptor alpha; Herbicides; Mice; Microwaves; Paraquat; Parkinson Disease; Piperidines; Pyrazoles; Solvents; Tandem Mass Spectrometry

2009
Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation.
    Journal of neurochemistry, 2012, Volume: 122, Issue:5

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine Triphosphate; Adrenergic Agents; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Line, Transformed; Dopamine Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Energy Metabolism; Herbicides; Insecticides; Neurotoxins; Oligomycins; Oxidopamine; Oxygen Consumption; Paraquat; Proton Ionophores; Rats; Rotenone; Superoxides; Time Factors

2012
Letter to the editor regarding "Quantification of paraquat, MPTP, and MPP+ in brain tissue using microwave-assisted solvent extraction (MASE) and high-performance liquid chromatography-mass spectrometry".
    Analytical and bioanalytical chemistry, 2013, Volume: 405, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Paraquat; Piperidines; Pyrazoles; Tandem Mass Spectrometry

2013
Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice.
    Neurotoxicology, 2013, Volume: 37

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Astrocytes; Basal Ganglia; Cell Death; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Administration Schedule; Half-Life; Herbicides; Homovanillic Acid; Injections, Intraperitoneal; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Microglia; MPTP Poisoning; Nerve Degeneration; Paraquat; Substantia Nigra; Tyrosine 3-Monooxygenase

2013
Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease.
    Biochimica et biophysica acta, 2013, Volume: 1832, Issue:8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine; Homeodomain Proteins; Levodopa; Male; Maneb; Metalloporphyrins; Mice; Microglia; Minocycline; Mitochondria; Paraquat; Parkinson Disease, Secondary; Proteome; Stathmin; Superoxide Dismutase

2013
Parkinson's disease, lights and melanocytes: looking beyond the retina.
    Scientific reports, 2014, Jan-29, Volume: 4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Female; Light; Male; Melanocytes; Motor Activity; Oxidopamine; Paraquat; Parkinson Disease; Rats; Rats, Sprague-Dawley; Retina; Rotenone

2014
Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates MPTP-Induced Parkinsonism.
    Molecular neurobiology, 2015, Volume: 52, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Behavior, Animal; Cell Survival; Cells, Cultured; Dopaminergic Neurons; Epoxide Hydrolases; Lauric Acids; Male; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Paraquat; Parkinsonian Disorders; Rotarod Performance Test; Solubility; Substantia Nigra; Tyrosine 3-Monooxygenase; Up-Regulation

2015
Astrocytic JWA deletion exacerbates dopaminergic neurodegeneration by decreasing glutamate transporters in mice.
    Cell death & disease, 2018, 03-02, Volume: 9, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Transport System X-AG; Animals; Astrocytes; Carrier Proteins; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Excitatory Amino Acid Transporter 2; Gene Knockout Techniques; Glial Fibrillary Acidic Protein; Glutamic Acid; Heat-Shock Proteins; Male; Membrane Transport Proteins; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; MPTP Poisoning; Neurogenesis; Neurotoxins; Paraquat; Phosphatidylinositol 3-Kinases; STAT3 Transcription Factor

2018