papaverine and haloperidol

papaverine has been researched along with haloperidol in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199013 (37.14)18.7374
1990's1 (2.86)18.2507
2000's10 (28.57)29.6817
2010's8 (22.86)24.3611
2020's3 (8.57)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Caron, G; Ermondi, G1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Sen, S; Sinha, N1
Chappie, TA; Helal, CJ; Hou, X1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Chłoń-Rzepa, G; Dąbrowska, M; Jankowska, A; Komsta, Ł; Pawłowski, M; Ślusarczyk, M; Starek, M; Zagórska, A1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Kobayashi, RM1
Carchedi, F; Casacchia, M; Cerbo, R; Meco, G1
Asano, M; Hidaka, H1
Bidzinski, A; Gajewska, S; Hauptman, M; Kostowski, W1
Clyne, KE; Juhl, R1
Ackerman, M; Artman, LD; Asin, KE; Bednarz, L; Johnson, MC; Kebabian, JW; Kerkman, DJ; MacKenzie, RG; Montana, W; Stampfli, H1
Petkov, V; Todorov, S1
Kocher, R; Rohrer, G1
De Fina, V; Duzzi, L; Valsecchi, B1
Johnstone, M1
Buchel, L; Gallaire, D1
Cubeddu, LX; Hoffman, IS1
Alroy, G; Azzam, Z; Krivoy, N; Zinder, O1
Dikic, B; Kassiou, M; Katsifis, A; Mardon, K; Mattner, F1
Chambers, L; Chapin, DS; Harms, JF; Lebel, LA; McCarthy, SA; Menniti, FS; Schmidt, CJ; Shrikhande, A; Siuciak, JA; Wong, S1
Becker, A; Grecksch, G1
Breier, M; Ko, D; Marzan, DE; Swerdlow, NR; Thangaraj, N; Weber, M1
Dedeurwaerdere, S; Langlois, X; Vanhoof, G; Wintmolders, C1
Dvořák, M; Kubáň, P; Miková, B; Ryšavá, L1

Reviews

1 review(s) available for papaverine and haloperidol

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for papaverine and haloperidol

ArticleYear
[Treatment of severe chronic pains with a combination of thymoleptics and neuroleptics (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1974, Dec-31, Volume: 63, Issue:52

    Topics: Adult; Antidepressive Agents; Atropine; Chlorpromazine; Clinical Trials as Topic; Clomipramine; Drug Combinations; Female; Haloperidol; Humans; Imipramine; Male; Methotrimeprazine; Middle Aged; Morphine; Neoplasms; Pain; Papaverine; Tranquilizing Agents

1974
The effects of sedation on the digital plethysmogram. A radiotelemetric study of haloperidol.
    Anaesthesia, 1967, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Anxiety; Blood Vessels; Drug Antagonism; Drug Synergism; Female; Fingers; Haloperidol; Halothane; Humans; Male; Meperidine; Middle Aged; Papaverine; Plethysmography; Preanesthetic Medication; Promethazine; Scopolamine; Thiopental

1967

Other Studies

32 other study(ies) available for papaverine and haloperidol

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Current landscape of phosphodiesterase 10A (PDE10A) inhibition.
    Journal of medicinal chemistry, 2012, Sep-13, Volume: 55, Issue:17

    Topics: Animals; Cyclic AMP; Cyclic GMP; Humans; Hydrolysis; Mice; Models, Molecular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity.
    Bioorganic & medicinal chemistry letters, 2021, 10-01, Volume: 49

    Topics: Analgesics; Benzeneacetamides; Cyclic Nucleotide Phosphodiesterases, Type 7; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Phenylbutyrates; Phosphodiesterase 4 Inhibitors; Principal Component Analysis; Quantitative Structure-Activity Relationship; TRPA1 Cation Channel; Xanthines

2021
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Drug therapy of tardive dyskinesia.
    The New England journal of medicine, 1977, Feb-03, Volume: 296, Issue:5

    Topics: Age Factors; Antipsychotic Agents; Brain; Dopamine; Dyskinesia, Drug-Induced; Haloperidol; Humans; Lithium; Papaverine; Parasympatholytics; Parasympathomimetics; Phenothiazines; Pimozide; Receptors, Dopamine; Reserpine; Tetrabenazine

1977
[Effect of phosphodiesterase inhibitors on neuroleptic-induced catalepsy and apomorphine-induced stereotypic movements in rats].
    Bollettino della Societa italiana di biologia sperimentale, 1978, Apr-30, Volume: 54, Issue:8

    Topics: Animals; Apomorphine; Atropine; Catalepsy; Haloperidol; Humans; Movement Disorders; Papaverine; Phosphodiesterase Inhibitors; Rats

1978
Relaxation of isolated rabbit arteries by fusaric (5-butylpicolinic) acid.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:3

    Topics: Aminophylline; Angiotensin II; Animals; Arteries; Atropine; Calcium; Catecholamines; Female; Fusaric Acid; Haloperidol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Papaverine; Picolinic Acids; Potassium Chloride; Propranolol; Prostaglandins F; Rabbits; Serotonin

1976
Papaverine, drug-induced stereotypy and catalepsy and biogenic amines in the brain of the rat.
    Pharmacology, biochemistry, and behavior, 1976, Volume: 5, Issue:1

    Topics: Animals; Apomorphine; Behavior; Biogenic Amines; Brain; Brain Chemistry; Catalepsy; Dopamine; Haloperidol; Humans; Hydroxyindoleacetic Acid; Male; Norepinephrine; Papaverine; Rats; Serotonin; Stereotyped Behavior

1976
Tardive dyskinesia.
    American journal of hospital pharmacy, 1976, Volume: 33, Issue:5

    Topics: Choline; Deanol; Dopamine Antagonists; Haloperidol; Humans; Methyldopa; Movement Disorders; Papaverine; Parasympathomimetics; Reserpine; Tetrabenazine

1976
A-69024: a non-benzazepine antagonist with selectivity for the dopamine D-1 receptor.
    European journal of pharmacology, 1989, Aug-03, Volume: 166, Issue:3

    Topics: Adenylyl Cyclases; Animals; Apomorphine; Benzazepines; Binding, Competitive; Catalepsy; Dihydroxyphenylalanine; Haloperidol; Injections, Subcutaneous; Iodine Radioisotopes; Male; Motor Activity; Papaverine; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Tetrahydroisoquinolines

1989
[Interaction of stimulators and inhibitors of adenyl cyclase and phosphodiesterase with noradrenaline and acetylcholine].
    Eksperimentalna meditsina i morfologiia, 1974, Volume: 13, Issue:3

    Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gastrointestinal Motility; Guinea Pigs; Haloperidol; Ileum; Imidazoles; Isoproterenol; Lithium; Male; Muscle, Smooth; Norepinephrine; Papaverine; Phosphoric Diester Hydrolases; Rats; Theophylline; Vas Deferens

1974
[Variations in toxicologic responses of rats in relation to the type of enteric administration].
    Bollettino chimico farmaceutico, 1967, Volume: 106, Issue:12

    Topics: Animals; Caffeine; Diet; Haloperidol; Isoniazid; Male; Papaverine; Phenylbutazone; Phenylhydrazines; Phosphoric Acids; Rats; Thiazoles

1967
[Restraint ulcers in rats. II. Study of protective substances].
    Archives des sciences physiologiques, 1967, Volume: 21, Issue:4

    Topics: Animals; Barbiturates; Bis-Trimethylammonium Compounds; Butyrophenones; Chloral Hydrate; Chlorpromazine; Dextromoramide; Dibenzylchlorethamine; Female; Haloperidol; Hypnotics and Sedatives; Meprobamate; Papaverine; Parasympatholytics; Phenobarbital; Propranolol; Rats; Reserpine; Stomach Ulcer; Stress, Physiological; Tranquilizing Agents; Urethane

1967
Presynaptic effects of tetrahydropapaveroline on striatal dopaminergic neurons.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:1

    Topics: Animals; Apomorphine; Benztropine; Bromocriptine; Caudate Nucleus; Dopamine; Female; Haloperidol; In Vitro Techniques; Male; Neurons; Papaverine; Putamen; Rabbits; Synapses; Tetrahydropapaveroline

1982
Serum creatine kinase levels after a single intramuscular injection--dependence on injection volume.
    Annals of clinical biochemistry, 1994, Volume: 31 ( Pt 2)

    Topics: Adult; Aged; Aged, 80 and over; Creatine Kinase; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Hydralazine; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Papaverine; Paraldehyde

1994
Pharmacological evaluation of (+)-2- [123I]A-69024: a radioligand for in vivo studies of dopamine D1 receptors.
    Life sciences, 2001, Jun-29, Volume: 69, Issue:6

    Topics: Animals; Benzazepines; Brain; Cerebellum; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; Injections, Intravenous; Iodine Radioisotopes; Ketanserin; Ligands; Male; Papaverine; Rats; Rats, Wistar; Receptors, Dopamine D1; Spiperone; Stereoisomerism; Tetrahydroisoquinolines; Tetrahydronaphthalenes; Tissue Distribution; Tomography, Emission-Computed, Single-Photon

2001
Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis.
    Neuropharmacology, 2006, Volume: 51, Issue:2

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Central Nervous System Stimulants; Corpus Striatum; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Dendritic Spines; Dextroamphetamine; Drug Synergism; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Haloperidol; Mice; Mice, Knockout; Motor Activity; Papaverine; Phencyclidine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Rats

2006
Phosphodiesterase inhibitors--are they potential neuroleptic drugs?
    Behavioural brain research, 2008, Jan-25, Volume: 186, Issue:2

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Activity; Papaverine; Phosphodiesterase Inhibitors; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Risperidone; Rolipram

2008
Evaluating the antipsychotic profile of the preferential PDE10A inhibitor, papaverine.
    Psychopharmacology, 2009, Volume: 203, Issue:4

    Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Biological Availability; Body Temperature; Dopamine Agonists; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Activity; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reflex, Startle

2009
Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse: a potential translational biomarker.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:1

    Topics: Animals; Antimetabolites; Antipsychotic Agents; Autoradiography; Benzazepines; Biomarkers; Brain Chemistry; Densitometry; Deoxyglucose; Dopamine Agonists; Dose-Response Relationship, Drug; Glucose; Haloperidol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Modification, Translational

2011
Hollow Fiber Liquid-Phase Microextraction At-Line Coupled to Capillary Electrophoresis for Direct Analysis of Human Body Fluids.
    Analytical chemistry, 2020, 05-19, Volume: 92, Issue:10

    Topics: Body Fluids; Electrophoresis, Capillary; Haloperidol; Humans; Liquid Phase Microextraction; Loperamide; Nortriptyline; Papaverine; Particle Size; Porosity; Surface Properties

2020