papaverine and 1-methyl-3-isobutylxanthine

papaverine has been researched along with 1-methyl-3-isobutylxanthine in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	51 (66.23)	18.7374
1990's	18 (23.38)	18.2507
2000's	5 (6.49)	29.6817
2010's	3 (3.90)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Bristol, JA; Cain, MH; Weishaar, RE	1
Chen, G; Ke, H; Kunz, S; Martinelli, S; Robinson, H; Seebeck, T; Wan, Y; Wang, H	1
de Esch, IJ; de Graaf, C; Jansen, C; Kanev, GK; Kooistra, AJ; Leurs, R	1
Chenet, A; Mohindru, A; Rhoads, AR	1
Forsyth, GW; Goertz, KE; Hamilton, DL; Johnson, MR	1
Maeno, H; Sakamoto, N; Takenaka, T; Terai, M	1
Brackett, NL; Helfman, DM; Kuo, JF; Shoji, M	1
Cubeddu, L; Hoffmann, IS; Paris, VB	1
Salaman, P; St Georgiev, V; Van Inwegen, RG; Weinryb, I	1
Mansour, JM; Mansour, TE	1
Corson, DW; Fein, A; Schmidt, J	1
Fein, A; Schmidt, JA	1
Butcher, RW; Nemecek, GM	1
Gauthier, C; Le Bec, A; Lugnier, C; Soustre, H	1
Watson, PA	1
Moser, A; Schuster, O	1
Moreno, S; Tomes, C	1
Kohno, S; Matsubayashi, H; Tsuru, H	1
Shikada, K; Tanaka, S; Yamamoto, A	1
Sadler, SE	1
Ooi, SO; Wong, EH	1
Nickols, GA	1
Hanawa, I; Toba, Y	1
de Gregorio, A; Marin, J; Salaices, M	2
Blazynski, C; Ferrendelli, JA; Geary, KM; Kinscherf, DA	1
Oomura, Y; Shimizu, N	1
Furchgott, RF; Jothianandan, D; Martin, W; Villani, GM	1
Gemba, M; Mikuriya, N; Nakajima, M; Nakanishi, J	1
Cline, WH; Metz, MA; Nickols, GA	1
Duemler, BH; Keravis, TM; Kuttesch, NJ; Sullivan, TA; Wells, JN	1
Greeff, K; Schmitt, M	1
Bryson, SE; Rodger, IW	1
Barber, B; Fluck, R; Sguigna, C	1
Maller, JL; Sadler, SE	1
Chiba, S; Haruta, K; Homma, N; Horiuchi, A; Iwatsuki, K; Yonekura, H	1
Holtzman, SG	1
Dumler, IL; Govardovskiĭ, VI	1
Fermum, R; Leibelt, M; Möritz, KU; Schäfer, U	1
Hertelendy, F; Zakar, T	1
Gagnon, G; Regoli, D; Rioux, F	2
Bakshian, S; Edwards, RB	1
Churchill, MC; Churchill, PC; McDonald, FD	1
Hagino, Y; Tachibana, M; Tsuru, H; Uematsu, T	1
Gruschwitz, P; Nawrath, H; Zong, X	1
Bochkin, LM; Ostrovskiĭ, MA; Zak, PP	1
Ahluwalia, GS; Rhoads, AR	1
Azuma, K; Azuma, M	1
Blankenship, LC; Craven, SE	1
Sass, SP; Sheppard, H; Tsien, WH	1
Said, HM; Strum, WB	1
Hidaka, H; Manganiello, VC; Osborne, JC; Vaughan, M; Yamamoto, S; Yamamoto, T	1
Macfarlane, DE	1
Coquil, JF; Franks, DJ; Hamet, P; Tremblay, J	1
Plagemann, PG; Wohlhueter, RM	1
Altman, HJ; Barraco, RA; Coffin, VL; Phillis, JW; Taylor, JA	1
Nathanson, JA	1
Stellwagen, RH; Strinden, ST	1
Fujita, H; Kurahashi, K; Usui, H; Yoshikawa, M	1
Ogihara, M	1
Babcock, DF; Cook, SP	2
Moreau, M; Mubagwa, K; Pappano, AJ; Shirayama, T	1
D'Souza, T; Dryer, SE	1
Capasso, F; Costa, M; Izzo, AA; Mascolo, N	1
Bełtowski, J; Górny, D; Marciniak, A	1
Bernabe, J; Dashkovsky, A; Giuliano, F; Rogowski, Z; Tarchnishvili, A; Vardi, Y; Yarnitsky, D	1
Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M	1
Goto, T; Hida, A; Hosaka, Y; Kasuya, Y; Kawabe, K; Kitamura, T; Matsushima, H; Ohta, Y; Simizu, T; Takeda, K	1
Garfield, RE; Jain, V; Okawa, T; Saade, GR; Syal, AS; Vedernikov, YP	1
Harayama, H; Kato, S	1
Andersson, TP; Sköld, HN; Svensson, SP	1
Alonso, GD; Flawiá, MM; Schoijet, AC; Torres, HN	1
Bulaeva, SV; Chuchkanov, FA; Maimistova, AA; Muravyov, AV; Yakusevich, VV; Zaitsev, LG	1
Corradini, E; Heck, AJ; Klaasse, G; Leurs, U; Martin, NI; Scholten, A	1

Reviews

1 review(s) available for papaverine and 1-methyl-3-isobutylxanthine

Article	Year
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. Journal of medicinal chemistry, 1985, Volume: 28, Issue:5 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity	1985

Article

Year

A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.

Journal of medicinal chemistry, 1985, Volume: 28, Issue:5

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity

1985

Other Studies

76 other study(ies) available for papaverine and 1-methyl-3-isobutylxanthine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. The Journal of biological chemistry, 2012, Apr-06, Volume: 287, Issue:15 Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Design; Kinetics; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Sulfonamides; Surface Properties; Trypanosoma cruzi	2012
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design. Journal of medicinal chemistry, 2016, Aug-11, Volume: 59, Issue:15 Topics: Databases, Protein; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship	2016
Chromatographic behavior of cyclic 3',5'-nucleotide phosphodiesterases on columns of immobilized inhibitors. Biochemistry, 1978, Aug-08, Volume: 17, Issue:16 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Brain; Cattle; Chromatography, Affinity; Kinetics; Myocardium; Papaverine	1978
Cholera toxin effects on fluid secretion, adenylate cyclase, and cyclic AMP in porcine small intestine. Infection and immunity, 1978, Volume: 21, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cell-Free System; Cholera Toxin; Cyclic AMP; Dose-Response Relationship, Drug; Intestinal Mucosa; Intestinal Secretions; Intestine, Small; Papaverine; Rabbits; Sodium; Swine	1978
Inhibition of cyclic AMP phosphodiesterase by 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)] ethyl ester 5-methyl ester hydrochloride (YC-93), a potent vasodilator. Biochemical pharmacology, 1978, Volume: 27, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cattle; Coronary Vessels; Cyclic AMP; Dogs; In Vitro Techniques; Kinetics; Male; Myocardium; Nitrobenzenes; Papaverine; Pyridines; Structure-Activity Relationship; Vasodilator Agents	1978
Effects of phosphodiesterase inhibitors, imidazole and phosphate on cyclic CMP phosphodiesterase are different from those on cyclic AMP and cyclic GMP phosphodiesterases. Journal of cyclic nucleotide research, 1978, Volume: 4, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Imidazoles; Liver; Male; Myocardium; Organ Specificity; Papaverine; Phosphates; Phosphodiesterase Inhibitors; Rats; Theophylline	1978
Effects of papaverine on the release and metabolism of dopamine in rat striatum. The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Animals; Biotransformation; Bucladesine; Caudate Nucleus; Dopamine; In Vitro Techniques; Male; Papaverine; Potassium; Putamen; Rats	1979
Dihydro- and tetrahydroisoquinolines as inhibitors of cyclic nucleotide phosphodiesterases from dog heart. Structure-activity relationships. Biochemical pharmacology, 1979, Apr-15, Volume: 28, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Dogs; In Vitro Techniques; Isoquinolines; Kinetics; Male; Myocardium; Osmolar Concentration; Papaverine; Structure-Activity Relationship	1979
Effect of some phosphodiesterase inhibitors on adenylate cyclase from the liver fluke, Fasciola hepatica. Biochemical pharmacology, 1979, Jun-15, Volume: 28, Issue:12 Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Etazolate; Fasciola hepatica; Guanosine Triphosphate; Kinetics; Papaverine; Phosphodiesterase Inhibitors; Quinazolines; Serotonin	1979
Two effects of phosphodiesterase inhibitors on Limulus ventral photoreceptors. Brain research, 1979, Nov-02, Volume: 176, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Horseshoe Crabs; Membrane Potentials; Papaverine; Photic Stimulation; Photoreceptor Cells; Theophylline	1979
Effects of calcium-blocking agents and phosphodiesterase inhibitors on voltage-dependent conductances in Limulus photoreceptors. Brain research, 1979, Nov-02, Volume: 176, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Gallopamil; Horseshoe Crabs; Membrane Potentials; Papaverine; Photic Stimulation; Photoreceptor Cells; Potassium; Synaptic Transmission; Theophylline	1979
Dissimilar cyclic nucleotide phosphodiesterase activities in subcellular fractions from normal and SV40-transformed WI-38 fibroblasts. Journal of cyclic nucleotide research, 1979, Volume: 5, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Cell Line; Cell Transformation, Viral; Chromatography, DEAE-Cellulose; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Fibroblasts; Humans; Kinetics; Papaverine; Simian virus 40; Subcellular Fractions	1979
Cyclic nucleotide phosphodiesterases from frog atrial fibers: isolation and drug sensitivities. The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 2 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium Chloride; Calmodulin; Chromatography, Ion Exchange; Cyclic GMP; Cytosol; Dipyridamole; Heart Atria; Heart Ventricles; Kinetics; Myocardium; Papaverine; Purinones; Pyrrolidinones; Rana esculenta; Rana ridibunda; Rolipram; Substrate Specificity; Theophylline	1992
Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling. The Journal of biological chemistry, 1990, Apr-25, Volume: 265, Issue:12 Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Calcimycin; Calcium; Cell Line; Colchicine; Cyclic AMP; Cytochalasin B; Ionomycin; Kinetics; Lymphoma; Mice; Miconazole; Papaverine; Pertussis Toxin; Tumor Cells, Cultured; Virulence Factors, Bordetella	1990
Iron inhibits D-1 dopamine receptor coupled adenylate cyclase via G-proteins in the caudate nucleus of the rat. Biochemical and biophysical research communications, 1990, Sep-28, Volume: 171, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Caudate Nucleus; Cholera Toxin; Colforsin; Dopamine; Female; Ferrous Compounds; GTP-Binding Proteins; Guanine Nucleotides; Kinetics; Papaverine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Virulence Factors, Bordetella	1990
cAMP analogs and selective inhibitors used to study low Km Mucor rouxii cAMP phosphodiesterase. The International journal of biochemistry, 1990, Volume: 22, Issue:9 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Centrifugation, Density Gradient; Cyclic AMP; Cyclic GMP; Dipyridamole; Hydrolysis; Mucor; Nicotinic Acids; Papaverine; Pyridazines; Theophylline	1990
Relaxation response of isolated canine veins to agents that act on the adenylate cyclase-cyclic AMP system: further investigation. European journal of pharmacology, 1990, Dec-04, Volume: 191, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Colforsin; Cyclic AMP; Dogs; Female; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Papaverine; Veins	1990
Effects of phosphodiesterase inhibitors on vasoactive intestinal peptide-induced relaxation of isolated guinea-pig trachea. European journal of pharmacology, 1991, Apr-03, Volume: 195, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dinoprostone; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Papaverine; Phosphodiesterase Inhibitors; SRS-A; Trachea; Vasoactive Intestinal Peptide	1991
Inhibitors of phosphodiesterase III block stimulation of Xenopus laevis oocyte ribosomal S6 kinase activity by insulin-like growth factor-I. Molecular endocrinology (Baltimore, Md.), 1991, Volume: 5, Issue:12 Topics: 1-Methyl-3-isobutylxanthine; Animals; Cricetinae; Female; Insulin-Like Growth Factor I; Meiosis; Oocytes; Oogenesis; Papaverine; Phosphodiesterase Inhibitors; Protein Kinases; Pyridazines; Pyrrolidinones; Ribosomal Protein S6 Kinases; Rolipram; Theophylline; Xenopus laevis	1991
Methylxanthine and non-xanthine phosphodiesterase inhibitors. Their effects on adenosine uptake and the low Km cyclic AMP phosphodiesterase in intact rat adipocyte. Biochemical pharmacology, 1985, Aug-15, Volume: 34, Issue:16 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adipose Tissue; Animals; Dipyridamole; Guanosine Triphosphate; In Vitro Techniques; Insulin; Kinetics; Lipolysis; Male; Papaverine; Rats; Rats, Inbred Strains; Xanthines	1985
Increased cyclic AMP in cultured vascular smooth muscle cells and relaxation of aortic strips by parathyroid hormone. European journal of pharmacology, 1985, Oct-08, Volume: 116, Issue:1-2 Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta, Thoracic; Cattle; Colforsin; Cyclic AMP; Drug Synergism; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Papaverine; Parathyroid Hormone; Rabbits; Sodium Fluoride; Time Factors	1985
Photoreceptor sensitivity as a function of rhodopsin content in the isolated bullfrog retina. The Japanese journal of physiology, 1985, Volume: 35, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Darkness; In Vitro Techniques; Kinetics; Papaverine; Photoreceptor Cells; Rana catesbeiana; Retina; Retinal Pigments; Rhodopsin	1985
Study of vasodilator effects of papaverine, adenosine and related drugs in isolated cat cerebral arteries. General pharmacology, 1985, Volume: 16, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Bucladesine; Cats; Cerebral Arteries; Cyclic AMP; Drug Interactions; In Vitro Techniques; Muscle, Smooth, Vascular; Papaverine; Vasoconstriction; Vasodilation; Vasodilator Agents	1985
Effect of some vasodilators on cat femoral arteries. The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Cats; Cyclic AMP; Femoral Artery; In Vitro Techniques; Muscle, Smooth, Vascular; Papaverine; Vasodilation; Vasodilator Agents	1986
Adenosine-mediated regulation of cyclic AMP levels in isolated incubated retinas. Brain research, 1986, Feb-26, Volume: 366, Issue:1-2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Cyclic AMP; Dopamine; Guinea Pigs; Mice; Norepinephrine; Papaverine; Rabbits; Rats; Retina; Species Specificity	1986
Calcitonin-induced anorexia in rats: evidence for its inhibitory action on lateral hypothalamic chemosensitive neurons. Brain research, 1986, Mar-05, Volume: 367, Issue:1-2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcitonin; Depression, Chemical; Drug Interactions; Feeding Behavior; Hypothalamic Area, Lateral; Male; Niacin; Norepinephrine; Papaverine; Rats; Rats, Inbred Strains; Serotonin	1986
Phosphodiesterase inhibitors induce endothelium-dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cyclic GMP; Drug Synergism; Endothelium; Hemoglobins; In Vitro Techniques; Isoproterenol; Male; Nitric Oxide; Nitroglycerin; Papaverine; Phosphodiesterase Inhibitors; Purinones; Rabbits; Rats; Rats, Inbred Strains; Vasodilation; Vasodilator Agents	1986
Influence of papaverine on cyclic nucleotide level and cellular metabolism in rat kidney cortex in terms of its inhibitory effect on p-aminohippurate transport. Journal of pharmacobio-dynamics, 1986, Volume: 9, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Aminohippuric Acids; Animals; Biological Transport; Calcium; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Kidney Cortex; Male; Mitochondria; Nucleotides, Cyclic; Ouabain; Oxygen Consumption; p-Aminohippuric Acid; Papaverine; Rats; Rats, Inbred Strains; Sodium; Theophylline	1986
Endothelium-independent linkage of parathyroid hormone receptors of rat vascular tissue with increased adenosine 3',5'-monophosphate and relaxation of vascular smooth muscle. Endocrinology, 1986, Volume: 119, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta, Thoracic; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium; Isoproterenol; Male; Membrane Proteins; Muscle Relaxation; Muscle, Smooth, Vascular; Papaverine; Parathyroid Hormone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Parathyroid Hormone; Teriparatide	1986
Irreversible inhibition of calmodulin-sensitive cyclic nucleotide phosphodiesterase. Journal of cyclic nucleotide and protein phosphorylation research, 1986, Volume: 11, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Affinity Labels; Animals; Calmodulin; Cerebral Cortex; Chymotrypsin; Cyclic AMP; Cyclic GMP; Papaverine; Photolysis; Swine; Triazines; Ultraviolet Rays	1986
Interaction of phosphodiesterase inhibitors triamterene, papaverine, theophylline, IBMX and amrinone with other positive inotropic acting substances on isolated guinea-pig atria. Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 287, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Colforsin; Drug Interactions; Electric Stimulation; Guinea Pigs; Heart Rate; Histamine; In Vitro Techniques; Male; Metaproterenol; Myocardial Contraction; Papaverine; Phosphodiesterase Inhibitors; Stimulation, Chemical; Theophylline; Triamterene	1987
Effects of phosphodiesterase inhibitors on normal and chemically-skinned isolated airway smooth muscle. British journal of pharmacology, 1987, Volume: 92, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Airway Resistance; Animals; Cyclic AMP; Cyclic GMP; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Male; Papaverine; Phosphodiesterase Inhibitors; Protein Kinases; Pyrazines	1987
Calcium dependence of rhythmic contractions of the Oryzias latipes blastoderm. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1988, Volume: 89, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastoderm; Bucladesine; Caffeine; Calcium; Calcium Channel Blockers; Cyprinodontiformes; Oryzias; Papaverine; Theophylline	1988
A similar pool of cyclic AMP phosphodiesterase in Xenopus oocytes is stimulated by insulin, insulin-like growth factor 1, and [Val12,Thr59]Ha-ras protein. The Journal of biological chemistry, 1989, Jan-15, Volume: 264, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Female; In Vitro Techniques; Insulin; Insulin-Like Growth Factor I; Kinetics; Membrane Proteins; Microinjections; Oocytes; Papaverine; Progesterone; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Somatomedins; Theophylline; Threonine; Valine; Xenopus	1989
Effects of DN-9693, a synthesized phosphodiesterase inhibitor, on pancreatic exocrine secretion in dogs. Japanese journal of pharmacology, 1989, Volume: 49, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Atropine; Cholecystokinin; Cimetidine; Dogs; Dose-Response Relationship, Drug; Female; Male; Pancreas; Pancreatic Juice; Papaverine; Phentolamine; Phosphodiesterase Inhibitors; Propranolol; Quinazolines; Secretin; Sulpiride; Theophylline	1989
Phosphodiesterase inhibitors potentiate opiate-antagonist discrimination by morphine-dependent rats. Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Body Weight; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Male; Morphine; Naltrexone; Narcotic Antagonists; Papaverine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders	1989
[Effect of liposomes containing antibodies to cyclic nucleotide phosphodiesterase on the receptor potential of rods and cones of the frog retina]. Neirofiziologiia = Neurophysiology, 1985, Volume: 17, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antibodies; Calcium; In Vitro Techniques; Liposomes; Membrane Potentials; Papaverine; Photoreceptor Cells; Rana ridibunda	1985
[Adenosine-3',5'-monophosphate content and muscle tension in isolated coronary arteries under the effect of lanthanum ions]. Biomedica biochimica acta, 1984, Volume: 43, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Coronary Vessels; Cyclic AMP; In Vitro Techniques; Isoflurophate; Isoproterenol; Lanthanum; Muscle Contraction; Muscle, Smooth, Vascular; Papaverine; Theophylline; Trapidil	1984
Effects of mammalian LH, cyclic AMP and phosphodiesterase inhibitors on steroidogenesis, lactate production, glucose uptake and utilization by avian granulosa cells. Biology of reproduction, 1980, Volume: 22, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Chickens; Female; Glucose; Granulosa Cells; Lactates; Luteinizing Hormone; Papaverine; Phosphodiesterase Inhibitors; Progesterone; Sheep; Theophylline	1980
Studies on the mechanism of action of glucagon in strips of rabbit renal artery. British journal of pharmacology, 1980, Volume: 69, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic AMP; Female; Glucagon; In Vitro Techniques; Indomethacin; Male; Papaverine; Phosphodiesterase Inhibitors; Proadifen; Rabbits; Renal Artery; Theophylline; Vasodilator Agents; Verapamil	1980
Phagocytosis of outer segments by cultured rat pigment epithelium. Reduction by cyclic AMP and phosphodiesterase inhibitors. Investigative ophthalmology & visual science, 1980, Volume: 19, Issue:10 Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; In Vitro Techniques; Nicotinic Acids; Papaverine; Phagocytosis; Phosphodiesterase Inhibitors; Pigment Epithelium of Eye; Rats; Rod Cell Outer Segment	1980
Studies on the mechanism of action of various vasodilators. British journal of pharmacology, 1980, Volume: 70, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Calcium; Cyclic AMP; In Vitro Techniques; Isoproterenol; Muscle, Smooth, Vascular; Nitroglycerin; Papaverine; Rabbits; Vasodilator Agents; Verapamil	1980
Effects of papaverine on basal and on isoproterenol-stimulated renin secretion from rat kidney slices. Life sciences, 1980, Oct-06, Volume: 27, Issue:14 Topics: 1-Methyl-3-isobutylxanthine; Animals; Dose-Response Relationship, Drug; Isoproterenol; Kidney; Male; Papaverine; Rats; Renin	1980
Effect of thyroid hormone on cyclic AMP phosphodiesterase in rat kidney. Japanese journal of pharmacology, 1980, Volume: 30, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Hypothyroidism; In Vitro Techniques; Kidney Cortex; Kinetics; Male; Papaverine; Rats; Theophylline; Thyroxine; Triiodothyronine	1980
A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors. Experientia, 1981, Jul-15, Volume: 37, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Cats; Depression, Chemical; Dose-Response Relationship, Drug; Myocardial Contraction; Papaverine; Phosphodiesterase Inhibitors; Theophylline	1981
[Interrelationship between calcium and cyclic nucleotides in the functioning of retinal rods]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1981, Volume: 67, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic GMP; Drug Interactions; Male; Membrane Potentials; Papaverine; Photoreceptor Cells; Rana temporaria	1981
Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction. Biochemical pharmacology, 1982, Mar-01, Volume: 31, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calmodulin; Cattle; Cell Nucleus; Chlorpromazine; Egtazic Acid; Myocardium; Papaverine; Trifluoperazine	1982
The action of phosphodiesterase inhibitors on the hypersensitivity of frog photoreceptor. Vision research, 1982, Volume: 22, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; In Vitro Techniques; Light; Papaverine; Phosphodiesterase Inhibitors; Photoreceptor Cells; Rana catesbeiana; Theophylline	1982
Effect of purine derivatives, papaverine hydrochloride, and imidazole on enterotoxin formation by Clostridium perfringens type A. Canadian journal of microbiology, 1982, Volume: 28, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Clostridium perfringens; Enterotoxins; Imidazoles; Mercaptopurine; Papaverine; Spores, Bacterial; Theophylline	1982
The lack of correlation between inhibition of aggregation and cAMP levels with canine platelets. Thrombosis research, 1982, Nov-15, Volume: 28, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Animals; Arachidonic Acids; Cyclic AMP; Depression, Chemical; Dogs; Epinephrine; Female; Male; Papaverine; Phosphodiesterase Inhibitors; Platelet Aggregation; Prostaglandins E; Theophylline	1982
Cyclic adenosine-3',5'-monophosphate and folate transport in rat jejunum. Biochemical and biophysical research communications, 1983, Sep-15, Volume: 115, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Biological Transport, Active; Cyclic AMP; Folic Acid; Hydrocortisone; Jejunum; Male; Papaverine; Rats; Rats, Inbred Strains	1983
Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase. The Journal of biological chemistry, 1983, Dec-10, Volume: 258, Issue:23 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Dipyridamole; Hydrolysis; Kinetics; Liver; Papaverine; Quinolines; Quinolones; Theophylline	1983
Inhibitors of cyclic nucleotide phosphodiesterases inhibit protein carboxyl methylation in intact blood platelets. The Journal of biological chemistry, 1984, Jan-25, Volume: 259, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Dipyridamole; Humans; Hydrogen-Ion Concentration; Hydrolysis; Methionine; Mopidamol; Papaverine; Protein Methyltransferases; Protein O-Methyltransferase; S-Adenosylmethionine	1984
Rapid activation of cAMP phosphodiesterase in rat platelets. Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1983, Volume: 61, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alprostadil; Animals; Blood Platelets; Calcimycin; Calcium; Dipyridamole; Enzyme Activation; Epoprostenol; Indomethacin; Papaverine; Prostaglandins E; Protein Kinases; Rats	1983
Inhibition of the transport of adenosine, other nucleosides and hypoxanthine in novikoff rat hepatoma cells by methylxanthines, papaverine, N6-cyclohexyladenosine and N6-phenylisopropyladenosine. Biochemical pharmacology, 1984, Jun-01, Volume: 33, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Biological Transport, Active; Caffeine; Cell Line; Hypoxanthine; Hypoxanthines; Liver Neoplasms, Experimental; Papaverine; Phenylisopropyladenosine; Rats; Theophylline; Uridine; Xanthines	1984
Behavioral interaction of adenosine and methylxanthines on central purinergic systems. Neuroscience letters, 1984, Jun-15, Volume: 47, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Caffeine; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity; Papaverine; Theophylline	1984
Caffeine and related methylxanthines: possible naturally occurring pesticides. Science (New York, N.Y.), 1984, Oct-12, Volume: 226, Issue:4671 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Chlorphenamidine; Cyclic AMP; Feeding Behavior; Insecta; Insecticides; Larva; Lepidoptera; Moths; Papaverine; Pesticide Synergists; Theophylline; Xanthines	1984
Inhibition of guanylate cyclases by methylxanthines and papaverine. Biochemical and biophysical research communications, 1984, Sep-28, Volume: 123, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Guanylate Cyclase; Kinetics; Liver; Lung; Male; Organ Specificity; Papaverine; Rats; Rats, Inbred Strains; Theophylline	1984
Isolation and characterization of ovokinin, a bradykinin B1 agonist peptide derived from ovalbumin. Peptides, 1995, Volume: 16, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Bradykinin; Dinoprost; Dogs; Dose-Response Relationship, Drug; Egg Proteins; In Vitro Techniques; Mesenteric Arteries; Molecular Sequence Data; Muscle Relaxation; Muscle, Smooth, Vascular; Ovalbumin; Papaverine; Peptide Fragments; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rolipram; Vasodilator Agents	1995
Nifedipine and nicardipine potentiate glucagon-stimulated glycogenolysis in primary cultures of rat hepatocytes. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:9 Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glycogen; Liver; Male; Nicardipine; Nifedipine; Papaverine; Rats; Rats, Wistar	1993
Selective modulation by cGMP of the K+ channel activated by speract. The Journal of biological chemistry, 1993, Oct-25, Volume: 268, Issue:30 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Ammonium Chloride; Animals; Cyclic AMP; Cyclic GMP; Dimethyl Sulfoxide; Hydrogen-Ion Concentration; Kinetics; Male; Membrane Potentials; Oligopeptides; Papaverine; Potassium; Potassium Channels; Sea Urchins; Semen; Spermatozoa; Tetraethylammonium; Tetraethylammonium Compounds	1993
Activation of Ca2+ permeability by cAMP is coordinated through the pHi increase induced by speract. The Journal of biological chemistry, 1993, Oct-25, Volume: 268, Issue:30 Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Membrane Permeability; Cyclic AMP; Hydrogen-Ion Concentration; Kinetics; Male; Manganese; Membrane Potentials; Models, Biological; Oligopeptides; Papaverine; Sea Urchins; Semen; Signal Transduction; Spermatozoa; Zinc	1993
Effects of PDE inhibitors and carbachol on the L-type Ca current in guinea pig ventricular myocytes. The American journal of physiology, 1993, Volume: 265, Issue:4 Pt 2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Carbachol; Chloride Channels; Cyclic AMP; Cyclic GMP; Electric Conductivity; Guinea Pigs; Heart Ventricles; Myocardium; Papaverine; Parasympathomimetics; Phosphodiesterase Inhibitors	1993
Effects of phosphodiesterase inhibitors and forskolin on cyclic GMP-activated channels in intact isolated cells of the chick pineal gland. Neurochemistry international, 1995, Volume: 27, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Animals; Chick Embryo; Chickens; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Ion Channel Gating; Ion Channels; Papaverine; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pineal Gland	1995
Effect of papaverine on synaptic transmission in the guinea-pig ileum. British journal of pharmacology, 1997, Volume: 121, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Papaverine; Phosphoric Diester Hydrolases; Synaptic Transmission; Theophylline	1997
The mechanism of Na+, K+-ATPase inhibition by atrial natriuretic factor in rat renal medulla. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1998, Volume: 49, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Atrial Natriuretic Factor; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; Kidney Medulla; Male; Papaverine; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase	1998
Electrical activity from rat corpora is affected by pharmacological but not mechanical intracorporal manipulation. Pflugers Archiv : European journal of physiology, 1998, Volume: 436, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Animals; Electromyography; Epinephrine; Male; Muscle, Smooth; Papaverine; Penile Erection; Penis; Phosphodiesterase Inhibitors; Pressure; Rats; Rats, Sprague-Dawley	1998
Effects of phosphodiesterase inhibitors on cytokine production by microglia. Multiple sclerosis (Houndmills, Basingstoke, England), 1999, Volume: 5, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines	1999
The effect of papaverine on morphologic differentiation, proliferation and invasive potential of human prostatic cancer LNCaP cells. International journal of urology : official journal of the Japanese Urological Association, 1999, Volume: 6, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Cell Differentiation; Cell Division; Cell Size; Cyclic AMP; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Male; Neoplasm Invasiveness; Papaverine; Phosphodiesterase Inhibitors; Prostatic Neoplasms; Radioimmunoassay; Theophylline; Tumor Cells, Cultured	1999
The role of cyclic nucleotides in the spontaneous contractility and responsiveness to nitric oxide of the rat uterus at midgestation and term. American journal of obstetrics and gynecology, 2000, Volume: 182, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Myometrium; Nitric Oxide; Papaverine; Phosphodiesterase Inhibitors; Pregnancy; Rats; Rats, Sprague-Dawley; Uterine Contraction; Uterus	2000
Relationship between bicarbonate and cyclic nucleotide in the promoting effects on head-to-head agglutination in boar spermatozoa. Asian journal of andrology, 2002, Volume: 4, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; Cyclic GMP; Male; Papaverine; Purinergic P1 Receptor Antagonists; Sodium Bicarbonate; Sperm Agglutination; Sperm Head; Swine; Theophylline	2002
Phosphoinositide 3-kinase is involved in Xenopus and Labrus melanophore aggregation. Cellular signalling, 2003, Volume: 15, Issue:12 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Androstadienes; Animals; Chromones; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Kinetics; Melanocyte-Stimulating Hormones; Melanophores; Melanosomes; Melatonin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Norepinephrine; Papaverine; Perciformes; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Rolipram; Signal Transduction; Wortmannin; Xenopus laevis	2003
TcrPDEA1, a cAMP-specific phosphodiesterase with atypical pharmacological properties from Trypanosoma cruzi. Molecular and biochemical parasitology, 2007, Volume: 152, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Amino Acid Sequence; Animals; Calcium; Calmodulin; Coenzymes; Cyclic Nucleotide Phosphodiesterases, Type 1; DNA, Protozoan; Enzyme Activators; Enzyme Stability; Gene Dosage; Genetic Complementation Test; Guanosine Monophosphate; Magnesium; Molecular Sequence Data; Papaverine; Phosphodiesterase Inhibitors; Saccharomyces cerevisiae; Sequence Analysis, DNA; Substrate Specificity; Theophylline; Trypanosoma cruzi	2007
Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase activity: in vitro study. Clinical hemorheology and microcirculation, 2007, Volume: 36, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Adult; Blood Viscosity; Caffeine; Calcimycin; Calcium; Egtazic Acid; Erythrocyte Aggregation; Hemorheology; Humans; Male; Nifedipine; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Verapamil; Vinca Alkaloids	2007
Charting the interactome of PDE3A in human cells using an IBMX based chemical proteomics approach. Molecular bioSystems, 2015, Volume: 11, Issue:10 Topics: 1-Methyl-3-isobutylxanthine; 14-3-3 Proteins; Cyclic Nucleotide Phosphodiesterases, Type 3; HeLa Cells; Humans; Papaverine; Phosphodiesterase Inhibitors; Protein Binding; Protein Interaction Maps; Protein Phosphatase 2; Proteomics; Quinolones	2015