panaxadiol has been researched along with ginsenosides in 71 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (9.86) | 18.7374 |
| 1990's | 15 (21.13) | 18.2507 |
| 2000's | 9 (12.68) | 29.6817 |
| 2010's | 25 (35.21) | 24.3611 |
| 2020's | 15 (21.13) | 2.80 |
| Authors | Studies |
|---|---|
| Hamanaka, H; Hiai, S; Odaka, Y; Oura, H | 1 |
| Jiang, Y; Shao, C; Yue, G; Zhong, G | 1 |
| Chi, Q; Dang, Q; Guo, J | 1 |
| Jiang, Y; Wang, XQ; Yue, G; Zhong, GG | 1 |
| Hong, L; Li, XL; Li, YH; Liu, JY; Zhang, MY | 1 |
| Huang, SK; Liu, XD | 1 |
| Kim, JH; Kong, YC; Lau, CN; Woo, WS; Yip, TT; Yung, KH | 1 |
| Jiang, Y; Wang, XM; Wang, ZF; Zhang, WJ; Zhong, GG | 1 |
| Jiang, Y; Li, H; Li, YY; Qi, H; Sun, CW; Wang, XM; Yang, SJ; Zhao, CY; Zhong, GG | 1 |
| Wan, ZB; Wang, ZF; Xiao, JS; Yan, SZ | 1 |
| Chen, HC; Shao, CJ; Wang, XL; Xiao, DM; Xu, XP; Zhang, JB; Zhao, XJ; Zhou, WH | 1 |
| Dan, HX; Jia, JN; Xie, SR; Yao, JA; Zhang, BH | 1 |
| Chen, L; Jiang, Y; Ma, XY; Qi, H; Sun, CW; Xu, JD; Zhong, GG | 1 |
| Jiang, Y; Sun, XX; Wang, XM; Zhong, GG | 1 |
| Jia, Y; Liu, Q; Liu, Y; Zhao, B | 1 |
| Kai, L; Wang, ZF; Xiao, JS | 1 |
| Chang, MS; Lee, SG; Rho, HM | 1 |
| Cha, HJ; Chung, HY; Jeong, JW; Kim, KW; Kim, ND; Kim, OH; Kim, SI; Park, MT | 1 |
| Guo, XX; Liu, YF; Liu, YH | 1 |
| Jin, YH; Lee, SK; Park, JH; Yim, H | 1 |
| Choi, J; Jin, YH; Lee, KY; Lee, SK; Park, JH; Shin, S | 1 |
| FUJITA, M; ITOKAWA, H; SHIBATA, S | 1 |
| WAGNER-JAUREGG, T | 1 |
| FUJITA, M; ISHII, T; ITOKAWA, H; SHIBATA, S; TANAKA, O | 1 |
| ISHII, T; NAGAI, M; SHIBATA, S; TANAKA, O | 1 |
| Niu, YP; Qian, XD; Wang, WX | 1 |
| Gao, YG; Li, XG; Liu, YJ; Zhang, CH; Zhang, LX | 1 |
| de Barry, J; Liu, JW; Luu, B; Tian, SJ | 1 |
| Fang, GL; Gao, RL; Jin, JM; Lin, XJ | 1 |
| Gao, RL; Ling, SC; Sun, BQ; Zheng, LH; Zhou, J | 1 |
| Li, XL; Mehendale, SR; Sun, S; Wang, CZ; Wang, Q; Yuan, CS | 1 |
| Cho, SJ; Choi, JS; Kim, HY; Lee, SK; Lee, WH; Park, BD; Park, JH; Surh, YJ | 1 |
| Kim, TH; Lee, SM | 1 |
| Bi, Y; Jiang, N; Meng, Q; Wang, T; Zhang, J | 1 |
| Du, GJ; Rodriguez, M; Wang, CZ; Yuan, CS | 1 |
| Lin, ZH; Liu, XK; Piao, HR; Wu, Y; Ye, BJ; Zhao, YQ | 1 |
| Calway, T; Du, GJ; Du, W; He, TC; Somogyi, J; Wang, CZ; Wen, XD; Yuan, CS; Zhang, ZY | 1 |
| Calway, T; Du, GJ; Du, W; He, TC; Qi, LW; Wang, CZ; Yuan, CS; Zhang, ZY | 1 |
| Xiaojun, C; Yiping, R; Yu, P; Yuping, X; Zheng, X | 1 |
| An, L; Du, P; Han, X; Jiang, S; Li, H; Li, J; Ren, D; Xu, G; Yuan, G | 1 |
| Hui, G; Li, HD; Liu, W; Zhang, JZ; Zhao, B; Zhao, Y | 1 |
| Cao, MN; Guo, DA; He, WN; Lin, XH; Ye, M; Yu, SW | 1 |
| Jia, W; Jia, ZY; Wang, XY; Xie, X | 1 |
| Chong, BH; Gao, R; Jiang, X; Lin, X; Liu, Q; Xu, W; Yin, L | 1 |
| Gao, RL; Lin, XJ; Sun, X; Wen, WW; Yin, LM; Zheng, ZY; Zhuang, HF | 1 |
| Chen, Y; Du, Y; Fang, Y; Gao, P; Li, Y; Meng, Y; Wang, X; Yang, G; Zhao, X | 1 |
| Biswas, T; Kalra, A; Lal, RK; Mathur, A; Mathur, AK; Singh, M | 1 |
| Fan, G; Liang, Y; Yue, S; Zhang, H; Zhang, M; Zhu, J | 1 |
| Chong, BH; Gao, RL; Qian, S; Sun, X; Wang, LP; Yin, LM; Zhang, SZ; Zhao, YN | 1 |
| Chen, S; Piao, H; Sun, Y; Xiao, S; Zhao, Y; Zhou, W | 1 |
| Ai, Y; Chen, G; Chen, Z; Yan, B; Yin, G; Zhai, X | 1 |
| Chen, GT; Li, JL; Lin, HJ; Ren, J; Song, Y; Yan, SS; Zhai, XG | 1 |
| Hou, Y; Jia, W; Jia, Z; Kang, Y; Liu, J; Wang, J; Wang, X; Xie, X | 1 |
| Fu, Y | 1 |
| Kong, L; Liang, X; Lin, Y; Shi, Y; Xiao, H; Yang, J; Yao, Y | 1 |
| Ding, M; He, C; Lin, Z; Wang, Z; Zhao, Y | 1 |
| Lin, Z; Lu, J; Wang, X; Xiao, S; Zhao, Y | 1 |
| Cao, H; Gao, X; Hu, X; Hua, H; Li, D; Li, H; Li, Z; Liu, W; Wang, M; Xu, F | 1 |
| Jiang, CG; Jin, CH; Jin, HL; Jin, X; Li, MY; Ma, J; Piao, LX; Ri, M; Wang, JY; Wang, Z; Xing, Y; Xu, GH; Zhang, ZH; Zuo, HX | 1 |
| Cao, J; Li, T; Wang, X; Xiao, S; Xu, L; Zhao, Y | 1 |
| Jin, XJ; Li, YW; Lv, LY; Piao, HR; Wang, DY; Zhang, LH; Zhao, YQ | 1 |
| Jiang, H; Li, X; Sun, B; Wang, Z; Xiao, S; Xu, L; Zhang, X; Zhao, Y | 1 |
| Fan, X; Fu, H; Fu, T; Guo, H; Shan, Y; Xie, N | 1 |
| Jin, HL; Jin, X; Lee, JJ; Li, MY; Ma, J; Wang, JY; Xing, Y; Zhang, ZH; Zhong, Y; Zuo, HX | 1 |
| Chen, L; Feng, J; Ge, Y; Guan, F; Han, H; Lv, Y; Xu, M; Yang, X; Zhang, M; Zhang, Y; Zhao, J; Zhao, T | 1 |
| Lee, JJ; Li, X; Xiao, S; Xu, L; Zhao, Y | 1 |
| Han, L; Lee, J; Li, T; Miao, D; Piao, H; Xiao, S; Zhao, Y | 1 |
| Jiang, H; Lee, JJ; Li, X; Xiao, S; Xu, L; Zhang, X; Zhao, Y | 1 |
| Chen, Y; Li, T; Su, G; Teng, J; Wang, G; Xiao, S; Zhao, Y | 1 |
| Deng, J; Hou, G; Jiang, S; Liu, S; Luan, M; Meng, Q; Wang, H; Wang, W; Yang, X; Zhang, J | 1 |
| Chen, Y; Dai, R; Gao, J; Lee, J; Li, T; Su, G; Wei, X; Zhao, Y | 1 |
2 review(s) available for panaxadiol and ginsenosides
| Article | Year |
|---|---|
Current studies on anti-endotoxic chemical components of traditional Chinese medicine in China.
Topics: Alkaloids; Animals; Antitoxins; Benzylisoquinolines; Colchicine; Diterpenes; Drugs, Chinese Herbal; Endotoxins; Ginkgolides; Ginsenosides; Humans; Lactones; Matrines; Pyrazines; Quinolizines; Saponins; Solanaceous Alkaloids; Taurine; Triterpenes | 2001 |
Dammarane-type leads panaxadiol and protopanaxadiol for drug discovery: Biological activity and structural modification.
Topics: Antineoplastic Agents; Dammaranes; Drug Discovery; Ginsenosides; Humans; Neuroprotective Agents; Panax; Phytochemicals; Radiation-Protective Agents; Sapogenins; Triterpenes | 2020 |
69 other study(ies) available for panaxadiol and ginsenosides
| Article | Year |
|---|---|
A color reaction of panaxadiol with vanillin and sulfuric acid.
Topics: Color; Flavoring Agents; Ginsenosides; Hydroxysteroids; Indicators and Reagents; Panax; Plants, Medicinal; Pyrans; Saponins; Sulfuric Acids; Temperature | 1975 |
[Ca2+ channel blocking effect of panaxadiol saponins and panaxatriol saponins of cultured cardiac cells].
Topics: Action Potentials; Calcium Channel Blockers; Cells, Cultured; Ginsenosides; Myocardium; Panax; Plants, Medicinal; Saponins; Triterpenes | 1992 |
[Thin layer chromatography and extractive technology of Panax japonicum C.A. Mey. var. major (Burk.) C. Y. Wu et K. M. Feng growing in Qingba Mountain Area].
Topics: Alkynes; Chromatography, Thin Layer; Drugs, Chinese Herbal; Enediynes; Fatty Alcohols; Ginsenosides; Oleanolic Acid; Panax; Plants, Medicinal; Saponins; Technology, Pharmaceutical; Triterpenes | 1992 |
[Effects of panaxadiol and panaxatriol saponins on action potentials of normal and xanthine-xanthine oxidase damaged cultured myocardial cells].
Topics: Action Potentials; Animals; Cells, Cultured; Ginsenosides; Heart; Myocardium; Panax; Plants, Medicinal; Rats; Rats, Inbred Strains; Saponins; Triterpenes; Xanthine Oxidase; Xanthines | 1991 |
[Determination of panaxadiol and panaxatriol in radix notoginseng and Yunnan baiyao by capillary supercritical fluid chromatography].
Topics: Chromatography; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Triterpenes | 1991 |
[Linear system analysis and physiological model in estimating disposition kinetics of sophocarpine in rats].
Topics: Alkaloids; Animals; Female; Ginsenosides; Male; Mathematics; Rabbits; Rats; Tissue Distribution; Triterpenes | 1988 |
Ginsenoside compositions of Panax ginseng C.A. Meyer tissue culture and juice.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Ginsenosides; Korea; Panax; Plants, Medicinal; Saponins; Triterpenes | 1985 |
[Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Cells, Cultured; Ginsenosides; Myocardium; Panax; Plants, Medicinal; Rats; Rats, Wistar; Triterpenes; Verapamil | 1994 |
[Calcium channel blockade and anti-free-radical actions of panaxadiol saponins Rb1, Rb2, Rb3, Rc, and Rd].
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Free Radical Scavengers; Ginsenosides; Myocardium; Panax; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Triterpenes | 1995 |
Protective effects of panaxadiol saponins on cardiac functions in burned rats.
Topics: Animals; Burns; Female; Free Radicals; Ginsenosides; Heart; In Vitro Techniques; Male; Myocardium; Rats; Rats, Wistar; Saponins; Superoxide Dismutase; Triterpenes | 1995 |
[Effect of panaxadiol saponin (PDS) on phorbol ester induced change of protein kinase C activity in cardiomyocytes].
Topics: Animals; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Ginsenosides; Myocardium; Phorbol Esters; Protein Kinase C; Rats; Saponins; Triterpenes | 1994 |
[Effects of panaxadiol saponins isolated from Panax notoginseng on intracellular and extracellular calcium].
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Channels; Colon; Female; Ginsenosides; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Rats; Triterpenes | 1993 |
[Influence of 11 ginsenoside monomers on action potentials of myocardiocytes].
Topics: Action Potentials; Animals; Cells, Cultured; Ginsenosides; Myocardium; Nimodipine; Rats; Rats, Wistar; Saponins; Triterpenes | 1993 |
[Anti-free-radical damaging action of panaxadiol saponins and panaxatriol saponins on the myocardial contractibility of the isolated rat working heart].
Topics: Animals; Female; Free Radical Scavengers; Ginsenosides; Hemodynamics; In Vitro Techniques; Male; Myocardial Contraction; Rats; Rats, Wistar; Triterpenes | 1993 |
[Determination of panaxadiol and panaxatriol in shihu yeguang pills].
Topics: Chromatography, Thin Layer; Densitometry; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Quality Control; Saponins; Triterpenes | 1995 |
L-type calcium channel blockade mechanisms of panaxadiol saponins against anoxic damage of cerebral cortical neurons isolated from rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cell Hypoxia; Cerebral Cortex; Ginsenosides; In Vitro Techniques; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Triterpenes; Verapamil | 1998 |
Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng.
Topics: Carcinoma, Hepatocellular; Catalase; DNA Primers; Galactosides; Gene Expression Regulation, Enzymologic; Ginsenosides; Humans; Liver Neoplasms; Panax; Plant Extracts; Plant Roots; Plants, Medicinal; Saponins; Superoxide Dismutase; Superoxide Dismutase-1; Transcriptional Activation; Triterpenes; Tumor Cells, Cultured | 1999 |
Glucocorticoid receptor-induced down-regulation of MMP-9 by ginseng components, PD and PT contributes to inhibition of the invasive capacity of HT1080 human fibrosarcoma cells.
Topics: Cell Nucleus; Cytosol; Dexamethasone; Enzyme Induction; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Ginsenosides; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Proteins; Panax; Plants, Medicinal; Receptors, Glucocorticoid; RNA, Messenger; Signal Transduction; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured | 1999 |
Cdk2 activity is associated with depolarization of mitochondrial membrane potential during apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspases; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cytochrome c Group; Ginsenosides; Humans; Intracellular Membranes; Liver Neoplasms; Membrane Potentials; Mitochondria; Protein Serine-Threonine Kinases; Triterpenes; Tumor Cells, Cultured; Up-Regulation | 2003 |
Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells.
Topics: CDC2-CDC28 Kinases; Cell Line; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Down-Regulation; Enzyme Inhibitors; G1 Phase; Ginsenosides; Humans; S Phase; Triterpenes | 2003 |
[Chemical studies on ginseng. II. (Studies on asponin-bearing drugs. V.). Some properties of panaxadiol].
Topics: Complementary Therapies; Ginsenosides; Panax; Saponins | 1962 |
[On the sapogenin panaxol or panaxadiol isolated from ginseng root].
Topics: Complementary Therapies; Ginsenosides; Humans; Panax; Sapogenins; Saponins | 1963 |
STUDIES ON THE CONSTITUENTS OF JAPANESE AND CHINESE CRUDE DRUGS. XI. PANAXADIOL, A SAPOGENIN OF GINSENG ROOTS.
Topics: Chemistry, Pharmaceutical; Ginsenosides; Panax; Plants, Medicinal; Research; Sapogenins; Saponins | 1963 |
STUDIES ON THE CONSTITUENTS OF JAPANESE AND CHINESE CRUDE DRUGS. XII. PANAXADIOL, A SAPOGENIN OF GINSENG ROOTS.
Topics: Chemistry, Pharmaceutical; Ginsenosides; Panax; Research; Sapogenins; Saponins | 1963 |
[Effect of panaxadiol saponin and panaxtrol saponin on proliferation of human bone marrow hemopoietic progenitor cells].
Topics: Bone Marrow Cells; Cell Differentiation; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Erythroid Precursor Cells; Ginsenosides; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Stem Cells; Humans; Panax; Saponins; Triterpenes | 2004 |
[Primary research on anti-tumor activity of panaxadiol fatty acid esters].
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Count; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Esters; Fatty Acids; Ginsenosides; Panax; Plants, Medicinal; Triterpenes; Vero Cells | 2006 |
Panaxadiol glycosides that induce neuronal differentiation in neurosphere stem cells.
Topics: Brain Stem; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epidermal Growth Factor; Ginsenosides; Glycosides; Molecular Structure; Neurodegenerative Diseases; Neurons; Nifedipine; Panax notoginseng; Plants, Medicinal; Stem Cells; Time Factors; Triterpenes | 2007 |
[Effects of Ginseng panaxadiol saponin on proliferation and differentiation of human bone marrow CD34+ cells].
Topics: Antigens, CD34; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Ginsenosides; Hematopoiesis; Hematopoietic Stem Cells; Humans; Panax; Saponins | 2007 |
[Cortical neuron apoptosis induced by beta-amyloid peptide and protective effect of panoxadiol in mice].
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Drugs, Chinese Herbal; Female; Fetus; Ginsenosides; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Peptide Fragments; Pregnancy; Proto-Oncogene Proteins c-bcl-2 | 2008 |
Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Drug Synergism; Fluorouracil; Ginsenosides; HCT116 Cells; Humans | 2009 |
Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation.
Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Synergism; Etoposide; Female; Ginsenosides; HeLa Cells; Humans; Korea; Liver Neoplasms; Medicine, East Asian Traditional; Membrane Potentials; Mitochondria; Mycotoxins; Phosphoserine; Stomach Neoplasms; Wortmannin | 2010 |
The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart.
Topics: Adenosine Triphosphate; Animals; Creatine Kinase; Ginsenosides; Glutathione; Heart; In Vitro Techniques; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Malondialdehyde; Myocardium; Panax; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins | 2010 |
Study on the structure-function relationship of 20(S)-panaxadiol and its epimeric derivatives in myocardial injury induced by isoproterenol.
Topics: Animals; Antioxidants; Creatine Kinase; Ginsenosides; Glutathione Peroxidase; Isomerism; Isoproterenol; Male; Malondialdehyde; Myocardial Ischemia; Myocardium; Panax; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Structure-Activity Relationship; Superoxide Dismutase | 2010 |
Letter to the editor: Panaxadiol's anticancer activity is enhanced by epicatechin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Camellia sinensis; Catechin; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Ginsenosides; Humans; Magnoliopsida; Panax; Phytotherapy; Plant Extracts; Vitis | 2010 |
Synthesis and anti-tumor evaluation of panaxadiol derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Ginsenosides; Humans; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship | 2011 |
Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 3; Caspase 9; Caspases; Colorectal Neoplasms; Drug Synergism; G1 Phase; Ginsenosides; HCT116 Cells; Humans; Irinotecan; Panax; Phytotherapy; Plant Extracts | 2012 |
The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells.
Topics: Annexin A5; Apoptosis; Catechin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Synergism; Ginsenosides; Humans; Molecular Docking Simulation | 2013 |
An UFLC-MS/MS method for quantification of panaxadiol in rat plasma and its application to a pharmacokinetic study.
Topics: Animals; Biological Availability; Chromatography, High Pressure Liquid; Drug Stability; Drugs, Chinese Herbal; Ginsenosides; Male; Panax; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sapogenins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Effects of compound K on hyperglycemia and insulin resistance in rats with type 2 diabetes mellitus.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Ginsenosides; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Male; Molecular Structure; Panax; Plant Roots; Rats; Rats, Wistar; Signal Transduction; Streptozocin | 2014 |
[Raman and DSC spectroscopic studies on the interaction between ginsenosides and DMPC bilayer membranes].
Topics: Calorimetry, Differential Scanning; Dimyristoylphosphatidylcholine; Ginsenosides; Molecular Conformation; Phase Transition; Spectrum Analysis, Raman; Transition Temperature | 2014 |
Biotransformation of 20(R)-panaxadiol by the fungus Rhizopus chinensis.
Topics: Antineoplastic Agents; Biotransformation; Colonic Neoplasms; Drug Screening Assays, Antitumor; Fungi; Ginsenosides; Humans; Hydroxylation; Lipopolysaccharides; Luciferases; Molecular Structure; NF-kappa B; Nuclear Magnetic Resonance, Biomolecular; Rhizopus; Stereoisomerism | 2014 |
[Comparative study of main components of ginseng on immune function of rats].
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Brain; Corticosterone; Ginsenosides; Glutathione; Immune System; Interferon-gamma; Interleukin-2; Interleukin-6; Killer Cells, Natural; Malondialdehyde; Nitric Oxide; Organ Size; Panax; Polysaccharides; Random Allocation; Rats, Wistar; Saponins; Spleen; Superoxide Dismutase; Thymus Gland; Thyrotropin | 2014 |
The effects of panaxadiol saponins on megakaryocytic maturation and immune function in a mouse model of immune thrombocytopenia.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocytes; Female; Ginsenosides; Humans; Macrophages; Male; Megakaryocytes; Mice, Inbred BALB C; Phagocytosis; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Saponins; Time Factors | 2015 |
Effects of panaxadiol saponins component as a new Chinese patent medicine on proliferation, differentiation and corresponding gene expression profile of megakaryocytes.
Topics: Blotting, Western; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Colony-Forming Units Assay; Drugs, Chinese Herbal; Flow Cytometry; Gene Expression Profiling; Ginsenosides; Humans; Megakaryocytes; Patents as Topic; Saponins; Stem Cells; Transcription Factors; Up-Regulation | 2016 |
Panaxadiol Saponin and Dexamethasone Improve Renal Function in Lipopolysaccharide-Induced Mouse Model of Acute Kidney Injury.
Topics: Acute Kidney Injury; Animals; Dexamethasone; Disease Models, Animal; Ginsenosides; Kidney; Lipopolysaccharides; Malondialdehyde; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Receptors, Glucocorticoid; Superoxide Dismutase | 2015 |
Elicitors' influenced differential ginsenoside production and exudation into medium with concurrent Rg3/Rh2 panaxadiol induction in Panax quinquefolius cell suspensions.
Topics: Bacillus; Cobalt; Culture Media; Ginsenosides; Hydrogen Peroxide; Nickel; Nitroprusside; Panax; Plant Cells; Pseudomonas; Trichoderma | 2016 |
Combination of Panaxadiol and Panaxatriol Type Saponins and Ophioponins From Shenmai Formula Attenuates Lipopolysaccharide-induced Inflammatory Injury in Cardiac Microvascular Endothelial Cells by Blocking NF-kappa B Pathway.
Topics: Animals; Cells, Cultured; Drug Combinations; Drug Therapy, Combination; Drugs, Chinese Herbal; Endothelial Cells; Ginsenosides; Inflammation; Inflammation Mediators; Lipopolysaccharides; Microvessels; NF-kappa B; Ophiopogon; Rats; Rats, Wistar; Saponins; Signal Transduction | 2017 |
Ginseng-Derived Panaxadiol Saponins Promote Hematopoiesis Recovery in Cyclophosphamide-Induced Myelosuppressive Mice: Potential Novel Treatment of Chemotherapy-Induced Cytopenias.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cyclophosphamide; Extracellular Signal-Regulated MAP Kinases; GATA1 Transcription Factor; Ginsenosides; Hematopoiesis; Mice; Mitogen-Activated Protein Kinase Kinases; Myeloid Cells; Panax; Pancytopenia; Phosphorylation; Proto-Oncogene Proteins c-kit; Saponins; Up-Regulation | 2018 |
Synthesis and anti-tumor evaluation of panaxadiol halogen-derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Ginsenosides; Halogens; Humans; Molecular Conformation; Structure-Activity Relationship | 2017 |
Microbial carbonylation and hydroxylation of 20(R)-panaxadiol by Aspergillus niger.
Topics: Aspergillus niger; Biotransformation; Cell Line; Ginsenosides; Hepatic Stellate Cells; Humans; Hydroxylation; Liver Cirrhosis; Magnetic Resonance Spectroscopy; Molecular Structure; NF-kappa B; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2018 |
(R)-panaxadiol by whole cells of filamentous fungus Absidia coerulea AS 3.3382.
Topics: Absidia; Cell Line; Ginsenosides; Humans; Liver Cirrhosis; Molecular Structure; NF-kappa B; Panax notoginseng; Spectrometry, Mass, Electrospray Ionization | 2018 |
Metabonomics Approach To Comparing the Antistress Effects of Four Panax ginseng Components in Rats.
Topics: Amino Acids; Animals; Anti-Anxiety Agents; Carboxylic Acids; Chromatography, Gas; Energy Metabolism; Ginsenosides; Immobilization; Male; Metabolome; Metabolomics; Panax; Plant Extracts; Polysaccharides; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stress, Psychological; Swimming | 2018 |
Biotransformation of ginsenoside Rb1 to Gyp-XVII and minor ginsenoside Rg3 by endophytic bacterium Flavobacterium sp. GE 32 isolated from Panax ginseng.
Topics: Biotransformation; DNA, Ribosomal; Flavobacterium; Ginsenosides; Glycoside Hydrolases; Hydrolysis; Panax; Phylogeny; Sapogenins; Saponins | 2019 |
Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Disease Models, Animal; Ginsenosides; Humans; Memory; Memory Disorders; Mice; Mice, Transgenic; Phosphorylation; Proteins; Proto-Oncogene Proteins c-fyn; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses | 2019 |
Esterified Derivatives of Panaxadiol and Their Inhibitory Effect on HL-60, THP-1, and PC-3 Cell Lines.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Ginsenosides; HL-60 Cells; Humans; Panax; PC-3 Cells | 2019 |
Synthesis and Cytotoxicity Evaluation of Panaxadiol Derivatives.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Ginsenosides; Humans; Molecular Structure; Structure-Activity Relationship | 2020 |
Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells.
Topics: Animals; Antineoplastic Agents; B7-H1 Antigen; Cell Line; Cell Proliferation; Colonic Neoplasms; Ginsenosides; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice, Inbred BALB C; Mice, Nude; STAT3 Transcription Factor; T-Lymphocytes | 2020 |
Novel panaxadiol triazole derivatives induce apoptosis in HepG-2 cells through the mitochondrial pathway.
Topics: Apoptosis; Ginsenosides; Hep G2 Cells; Humans; Mitochondria | 2020 |
Synthesis and evaluation of HIF-1α inhibitory activities of novel panaxadiol derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Ginsenosides; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Structure-Activity Relationship; Transcriptional Activation | 2020 |
Panaxadiol as a major metabolite of AD-1 can significantly inhibit the proliferation and migration of breast cancer cells: In vitro and in vivo study.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Ginsenosides; Humans; Molecular Structure; Structure-Activity Relationship | 2021 |
Inhibition of JAK2/STAT3 signaling pathway by panaxadiol limits the progression of pancreatic cancer.
Topics: Cell Line, Tumor; Cell Proliferation; Ginsenosides; Humans; Janus Kinase 2; Models, Molecular; Molecular Structure; Pancreatic Neoplasms; Signal Transduction; STAT3 Transcription Factor | 2021 |
Panaxadiol inhibits IL-1β secretion by suppressing zinc finger protein 91-regulated activation of non-canonical caspase-8 inflammasome and MAPKs in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Caspase 8; Colitis; Gene Knockdown Techniques; Ginsenosides; HEK293 Cells; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Neuroprotective Agents; Panax; THP-1 Cells; Ubiquitin-Protein Ligases | 2022 |
(20R)-Panaxadiol as a Natural Active Component with Anti-Obesity Effects on ob/ob Mice via Modulating the Gut Microbiota.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Gastrointestinal Microbiome; Ginsenosides; Mice; Mice, Inbred C57BL; Obesity; Panax; RNA, Ribosomal, 16S | 2022 |
Gender-Related Differences in Tissue Distribution, Excretion, and Metabolism Studies of Panaxadiol in Rats and Anti-inflammatory Study.
Topics: Animals; Anti-Inflammatory Agents; Female; Ginsenosides; Male; p38 Mitogen-Activated Protein Kinases; Rats; Sex Factors; Tissue Distribution; Tumor Necrosis Factor-alpha | 2022 |
Design, Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives of Panaxadiol.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Ginsenosides; Humans; Indoles; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2022 |
In Vivo Metabolites of Panaxadiol Inhibit HepG-2 Cell Proliferation by Inducing G1 Arrest and ROS-Mediated Apoptosis.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Line, Tumor; Cell Proliferation; G1 Phase; Ginsenosides; Reactive Oxygen Species | 2022 |
Novel ginsenoside derivatives induce apoptosis in HepG-2 cells via the MDM2-p53 signaling pathway.
Topics: Apoptosis; Caspase 3; Ginsenosides; Humans; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Tumor Suppressor Protein p53 | 2022 |
Synthesis and
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Ginsenosides; Humans; Neoplasms; Structure-Activity Relationship | 2023 |
Synthesis and Antitumor Activity of Panaxadiol Pyrazole and Isooxazole Derivatives.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Ginsenosides; Molecular Docking Simulation; Molecular Structure; Pyrazoles; Structure-Activity Relationship | 2023 |