Compounds > paliperidone
Page last updated: 2024-09-03

paliperidone and pimozide

paliperidone has been researched along with pimozide in 4 studies

Compound Research Comparison

Studies
(paliperidone)		Trials
(paliperidone)		Recent Studies (post-2010)
(paliperidone)		Studies
(pimozide)		Trials
(pimozide)		Recent Studies (post-2010) (pimozide)
240171,837143152

Protein Interaction Comparison

ProteinTaxonomypaliperidone (IC50)pimozide (IC50)
XBP1Homo sapiens (human)10
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.201
Ubiquitin carboxyl-terminal hydrolase 1Homo sapiens (human)2
Potassium channel subfamily K member 2Homo sapiens (human)1.8
Bile salt export pumpHomo sapiens (human)10
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)0.34
ATP-dependent translocase ABCB1Homo sapiens (human)2.2
Cytochrome P450 3A4Homo sapiens (human)9.7
DRattus norvegicus (Norway rat)0.0004
D(3) dopamine receptorRattus norvegicus (Norway rat)0.0004
ATP-dependent translocase ABCB1Mus musculus (house mouse)4.9
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.0004
D(4) dopamine receptorRattus norvegicus (Norway rat)0.0004
Mu-type opioid receptorHomo sapiens (human)0.372
Sodium channel protein type 1 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 4 subunit alphaHomo sapiens (human)0.054
Delta-type opioid receptorHomo sapiens (human)3.76
Kappa-type opioid receptorHomo sapiens (human)0.99
D(2) dopamine receptorRattus norvegicus (Norway rat)0.0004
Sodium channel protein type 7 subunit alphaHomo sapiens (human)0.054
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.201
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.152
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.201
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.201
Sodium channel protein type 5 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 9 subunit alphaHomo sapiens (human)0.054
WD repeat-containing protein 48Homo sapiens (human)2
Sodium channel protein type 2 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 3 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 11 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 8 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 10 subunit alphaHomo sapiens (human)0.054

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Giordanetto, F; Leach, AG; Zachariae, U1
Sen, S; Sinha, N1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

1 review(s) available for paliperidone and pimozide

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

3 other study(ies) available for paliperidone and pimozide

ArticleYear
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
    Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14

    Topics: Binding Sites; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Potassium Channel Blockers; Protein Binding; Protein Conformation

2009
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013