Compounds > pak 104p
Page last updated: 2024-09-03

pak 104p and verapamil

pak 104p has been researched along with verapamil in 3 studies

*Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent. [MeSH]

*Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent. [MeSH]

Compound Research Comparison

Studies
(pak 104p)		Trials
(pak 104p)		Recent Studies (post-2010)
(pak 104p)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
160017,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomypak 104p (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Akiyama, SI; Chen, ZS; Chuman, Y; Furukawa, T; Haraguchi, M; Seto, K; Shudo, N; Sumizawa, T; Tani, A1
Dagger, F; Essodaïgui, M; Frézard, F; Garnier-Suillerot, A; Moreira, ES1
Garnier-Suillerot, A; Loechariyakul, P; Saengkhae, C; Salerno, M1

Other Studies

3 other study(ies) available for pak 104p and verapamil

ArticleYear
Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P.
    Molecular pharmacology, 1997, Volume: 51, Issue:3

    Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Benzylisoquinolines; Cyclic P-Oxides; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Humans; Leukotriene C4; Multidrug Resistance-Associated Proteins; Nicotinic Acids; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine

1997
Energy-dependent efflux from Leishmania promastigotes of substrates of the mammalian multidrug resistance pumps.
    Molecular and biochemical parasitology, 1999, May-15, Volume: 100, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cyclic P-Oxides; Doxorubicin; Drug Resistance, Multiple; Energy Metabolism; Fluoresceins; Fluorescent Dyes; Leishmania; Nicotinic Acids; Phenothiazines; Tumor Cells, Cultured; Verapamil

1999
Relation between the ability of some compounds to modulate the MRP1-mediated efflux of glutathione and to inhibit the MRPl-mediated efflux of daunorubicin.
    Biochemical pharmacology, 2004, Dec-01, Volume: 68, Issue:11

    Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclic P-Oxides; Daunorubicin; Glutathione; Humans; Nicotinic Acids; Propionates; Quinolines; Tumor Cells, Cultured; Verapamil

2004