paclitaxel has been researched along with staurosporine in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (20.45) | 18.2507 |
| 2000's | 14 (31.82) | 29.6817 |
| 2010's | 17 (38.64) | 24.3611 |
| 2020's | 4 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Attardo, G; Blais, C; Bouffard, D; Cai, SX; Denis, R; Drewe, J; Gourdeau, H; Herich, J; Jia, S; Jiang, S; Kasibhatla, S; Kemnitzer, W; Labreque, D; Lamothe, S; Meerovitch, K; Rej, R; Storer, R; Tseng, B; Wang, Y; Zhang, H; Zhao, J | 1 |
| Avery, VM; Barnes, EC; Davis, RA; Healy, PC; Longden, J | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chai, H; de Blanco, EJ; Fuchs, JR; Kinghorn, AD; Lantvit, DD; Matthew, S; Ninh, TN; Ren, Y; Soejarto, DD; Swanson, SM | 1 |
| Liptrot, CH; Motti, CA; Nielson, JL; Ovenden, SP; Tapiolas, DM; Willis, RH; Wright, AD | 1 |
| Carcache de Blanco, EJ; Chai, H; Kinghorn, AD; Lantvit, DD; Matthew, S; Ninh, TN; Pan, L; Soejarto, DD; Swanson, SM; Zhang, X | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chang, LC; Chen, CH; Chen, Y; Choi, J; Hilliard, TS; Kawakami, JK; Li, Y; Miklossy, G; Paladino, D; Sarkaria, JN; Sun, D; Turkson, J; Wongwiwatthananukit, S; Youn, UJ; Yue, P; Zhang, M | 1 |
| Cui, MT; Goto, M; Lee, KH; Li, L; Morris-Natschke, SL; Ohkoshi, E; Wang, SB; Wang, XF; Xie, L; Yang, DX; Yuan, S | 1 |
| Hansen, MDH; Hargiss, JB; Herron, SR; Hoj, JP; Hoj, TH; Payne, CJ; Quinn, C; Ritchie, CA; Schuler, JT; Siddiqui-Jain, A | 1 |
| Anaya-Eugenio, GD; Burdette, JE; Chai, HB; Czarnecki, AA; de Blanco, EJC; Kinghorn, AD; Ninh, TN; Ren, Y; Soejarto, DD; Yuan, C | 1 |
| Addo, EM; Anaya-Eugenio, GD; Carcache de Blanco, EJ; Ezzone, N; Henkin, JM; Kinghorn, AD; Ninh, TN; Ren, Y; Soejarto, DD | 1 |
| Afratis, K; Gavras, H; Karamanos, NK; Koutsakis, C; Leonardi, S; Papaioannou, D; Piperigkou, Z; Rassias, G; Rigopoulou, D; Vachlioti, E | 1 |
| Arya, GC; Jaitak, V; Kaur, K | 1 |
| Abdi, I; Berger, BT; Berger, LM; Hanke, T; Joerger, AC; Knapp, S; Kronenberger, T; Poso, A; Raab, M; Rak, M; Sanhaji, M; Strebhardt, K; Tesch, R | 1 |
| C S, R; Kumar, AP; Meyer-Almes, FJ; Safuan, S; Schweipert, M; Tilekar, K; Upadhyay, N | 1 |
| Choi, BM; Chung, HT; Jun, CD; Kim, HM | 1 |
| Abraham, I; Aristoff, PA; Laborde, AL; Sampson, KE; Shelly, JA; Skulnick, HI; Wolf, CL | 1 |
| Inaguma, Y; Ito, H; Kato, K; Okamoto, K; Saga, S | 1 |
| McCaig, C; Rajnicek, A | 1 |
| Saijo, N | 1 |
| Ling, YH; Perez-Soler, R; Tornos, C | 1 |
| Abraham, I; Olsen, MK; Reszka, AA | 1 |
| Bhalla, K; Bullock, G; Huang, Y; Ibrado, AM; Nawabi, A; Ponnathpur, V; Ray, S; Reed, JC; Self, S | 1 |
| Akinaga, S; Akiyama, T; Courage, C; Gescher, A; Shimizu, M; Sugiyama, K; Tamaoki, T | 1 |
| Chambers, TC; Drake, RR; Jones, KE; McMasters, RA; Moyer, MP; Pitlyk, K; Saylors, RL; Wilbert, TN | 1 |
| Matsuoka, Y; Shimizu, S; Shinohara, Y; Tsujimoto, Y; Yoneda, Y | 1 |
| Fujikawa-Yamamoto, K; Ikeda, T; Murano, H; Ohdoi, C; Wang, S; Yamagishi, H | 1 |
| Bally, M; Dragowska, WH; Hu, Y; Mayer, L | 1 |
| Beck, J; Chen, J; Chernenko, G; Liu, H; Pater, A; Tang, SC; Xiong, J | 1 |
| Häkkinen, L; Koivisto, L; Larjava, H; Matsumoto, K; McCulloch, CA; Yamada, KM | 1 |
| Sun, QY; Yao, LJ | 1 |
| Chung, WH; Han, K; Han, KT; Kim, M; Kim, Y; Lim, J; Park, IY | 1 |
| Clarke, A; Dikovskaya, D; Jamieson, TJ; Kroboth, K; Meniel, V; Näthke, IS; Newton, IP; Oakley, A; Sansom, O; Schiffmann, D | 1 |
| Chen, T; Pan, W; Qi, J; Qu, J; Sun, L | 1 |
| Li, X; Liao, QP | 1 |
| Niu, R; Shi, Y; Wei, X; Yang, Y; Yu, M; Zang, F | 1 |
| Blache, C; Danan, JL; Daveau, M; Gidrol, X; Hiron, M; Saint-Auret, G; Salier, JP; Sulpice, E; Tendil, S | 1 |
| Bi, Y; Calhoun-Davis, T; Chen, X; Coletta, LD; Fokt, I; Klostergaard, J; Li, H; Liu, C; Priebe, W; Qin, J; Skora, S; Tang, DG; Yan, H; Zhang, Q | 1 |
| Breitenbuecher, F; Guyot, M; Hoffarth, S; Höhn, Y; Meiler, J; Schuler, M; Wesarg, E | 1 |
| Chang, J; Di, X; Fan, W; Shen, Y; Sui, M; Zhang, H | 1 |
| Guo, H; Jiang, L; Liu, H; Ma, J; Xu, Y; Yang, H; Yu, G; Yuan, C; Zhang, Y | 1 |
| Hahlbrock, A; Maushagen, R; Pfannerstill, AC; Pries, R; Rades, D; Rahmanzadeh, R; Reers, S; Stauber, R; Wollenberg, B | 1 |
| Hashimoto, M; Ishigaki, Y; Iwabuchi, K; Kamdar, RP; Matsui, T; Matsumoto, Y; Sakasai, R; Sharma, MK; Sunatani, Y | 1 |
2 review(s) available for paclitaxel and staurosporine
| Article | Year |
|---|---|
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Isoxazoles | 2021 |
New chemotherapeutic agents for the treatment of non-small cell lung cancer: the Japanese experience.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbazoles; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Docetaxel; Glucosides; Humans; Irinotecan; Japan; Lung Neoplasms; Mitomycin; Mitomycins; Neoplasms, Experimental; Paclitaxel; Purine Nucleosides; Staurosporine; Taxoids; Treatment Outcome; Vinblastine; Vinorelbine | 1998 |
42 other study(ies) available for paclitaxel and staurosporine
| Article | Year |
|---|---|
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.
Topics: Antineoplastic Agents; Apoptosis; Benzopyrans; Biopolymers; Caspases; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Dioxoles; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Poly(ADP-ribose) Polymerases; Structure-Activity Relationship; Tubulin | 2004 |
Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum.
Topics: Antineoplastic Agents, Phytogenic; Australia; Cell Line, Tumor; Crystallography, X-Ray; Cyclobutanes; Guaiacol; Humans; Inhibitory Concentration 50; Lauraceae; Lignans; Magnetic Resonance Spectroscopy; Plant Roots; Plants, Medicinal | 2009 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.
Topics: Antineoplastic Agents, Phytogenic; Clusiaceae; Drug Screening Assays, Antitumor; HT29 Cells; Humans; NF-kappa B; Plant Stems; Xanthones | 2011 |
Metachromins U-W: cytotoxic merosesquiterpenoids from an Australian specimen of the sponge Thorecta reticulata.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Porifera; Sesquiterpenes | 2011 |
Bioassay-guided isolation of constituents of Piper sarmentosum using a mitochondrial transmembrane potential assay.
Topics: Antineoplastic Agents; Apoptosis; Drug Screening Assays, Antitumor; Flavones; HL-60 Cells; HT29 Cells; Humans; Inhibitory Concentration 50; Membrane Potentials; Mitochondria; Piper; Vietnam | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.
Topics: alpha Karyopherins; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Drug Evaluation, Preclinical; Female; Glioma; Glucosephosphate Dehydrogenase; HSP110 Heat-Shock Proteins; Humans; Magnetic Resonance Spectroscopy; Mice, Nude; Microtubule-Associated Proteins; Molecular Docking Simulation; Molecular Structure; STAT3 Transcription Factor; Structure-Activity Relationship; Thioredoxin Reductase 1; Trans-Activators; Vimentin; Xenograft Model Antitumor Assays | 2015 |
Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemical Phenomena; Enzyme Activation; Humans; Inhibitory Concentration 50; Models, Molecular; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines | 2016 |
Pyridine-pyrimidine amides that prevent HGF-induced epithelial scattering by two distinct mechanisms.
Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epithelial Cells; Hepatocyte Growth Factor; Humans; MCF-7 Cells; Molecular Structure; Pyridines; Pyrimidines; Structure-Activity Relationship | 2017 |
Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; HT29 Cells; Humans; Membrane Potential, Mitochondrial; Molecular Conformation; NF-kappa B; Plant Extracts; Plant Leaves; Structure-Activity Relationship; Syzygium; Triterpenes; Ursolic Acid | 2018 |
Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apocynaceae; Apoptosis; Caspases; Cell Line, Tumor; Humans; I-kappa B Kinase; Male; Molecular Structure; Poly (ADP-Ribose) Polymerase-1; Prostate; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrans; Vietnam; Zebrafish | 2019 |
Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?
Topics: Anti-Bacterial Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; MCF-7 Cells; Quinolines; Receptor, Bradykinin B2 | 2021 |
Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Humans; Molecular Dynamics Simulation; Molecular Structure; Paclitaxel; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Pyridones; Pyrimidines; Rats, Sprague-Dawley; Structure-Activity Relationship | 2021 |
Multi-target weapons: diaryl-pyrazoline thiazolidinediones simultaneously targeting VEGFR-2 and HDAC cancer hallmarks.
Topics: | 2021 |
Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophages.
Topics: Actins; Alkaloids; Animals; Base Sequence; DNA Primers; Gene Expression Regulation; In Vitro Techniques; Interferon-gamma; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nitric Oxide; Paclitaxel; Polymyxin B; Protein Kinase C; Recombinant Proteins; Staurosporine; Tumor Necrosis Factor-alpha | 1995 |
K252a, KT5720, KT5926, and U98017 support paclitaxel (taxol)-dependent cells and synergize with paclitaxel.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbazoles; Cell Division; Cell Line; CHO Cells; Cricetinae; Drug Synergism; Indole Alkaloids; Indoles; Myosin-Light-Chain Kinase; Paclitaxel; Pyrroles; Staurosporine | 1994 |
Synthesis and accumulation of alphaB crystallin in C6 glioma cells is induced by agents that promote the disassembly of microtubules.
Topics: Animals; Aphidicolin; Colchicine; Crystallins; Culture Media, Serum-Free; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Glioma; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Microtubules; Mitosis; Paclitaxel; Protein Kinase Inhibitors; Rats; Staurosporine; Tubulin; Tumor Cells, Cultured | 1996 |
Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytochalasin B; Cytoskeleton; Embryo, Mammalian; Embryo, Nonmammalian; Enzyme Inhibitors; Gadolinium; GTP-Binding Proteins; Hippocampus; Indoles; Isoquinolines; Maleimides; Microtubules; Neurites; Neurons; Nocodazole; Paclitaxel; Pertussis Toxin; Protein Kinase Inhibitors; Rats; Spinal Cord; Staurosporine; Sulfonamides; Virulence Factors, Bordetella; Xenopus laevis | 1997 |
Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.
Topics: Antineoplastic Agents; Apoptosis; CDC28 Protein Kinase, S cerevisiae; Cyclin B; Cyclin B1; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; HeLa Cells; Humans; Mitosis; Nocodazole; Okadaic Acid; Paclitaxel; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured | 1998 |
KT5720 and U-98017 inhibit MAPK and alter the cytoskeleton and cell morphology.
Topics: Animals; Antibodies; Antineoplastic Agents, Phytogenic; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Size; CHO Cells; Cricetinae; Cytoskeleton; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Indoles; Mitogen-Activated Protein Kinase Kinases; Paclitaxel; Protein Kinases; Pyrroles; Staurosporine; Tubulin | 1998 |
Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26BCL-2 protein.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; DNA Fragmentation; Enzyme Inhibitors; G2 Phase; Genistein; Humans; Neoplasm Proteins; Paclitaxel; Phorbol 12,13-Dibutyrate; Proto-Oncogene Proteins c-bcl-2; S Phase; Staurosporine; Tumor Cells, Cultured | 1995 |
Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine).
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Drug Resistance, Neoplasm; G1 Phase; Humans; Lung Neoplasms; Paclitaxel; Protein Serine-Threonine Kinases; Staurosporine; Tumor Cells, Cultured | 1999 |
Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-X Protein; Butyrates; Camptothecin; Caspase 3; Caspases; Cell Survival; Colonic Neoplasms; Drug Interactions; Ganciclovir; Humans; Membrane Proteins; Paclitaxel; Peptide Hydrolases; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Simplexvirus; Staurosporine; Thymidine Kinase; Transfection; Tumor Cells, Cultured | 2000 |
Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Cytochrome c Group; Erythrocytes; Etoposide; HeLa Cells; Humans; Ion Channels; Mammals; Membrane Proteins; Mitochondria; Mitochondria, Liver; Mitochondrial Proteins; Molecular Sequence Data; Paclitaxel; Porins; Protein Conformation; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred Strains; Recombinant Proteins; Staurosporine; Transfection; Voltage-Dependent Anion Channels | 2001 |
Establishment of a tetraploid Meth-A cell line through polyploidization by demecolcine but not by staurosporine, K-252A and paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carbazoles; Cell Count; Cell Cycle; Cell Division; Demecolcine; DNA; Enzyme Inhibitors; Flow Cytometry; Indole Alkaloids; Karyotyping; Mice; Paclitaxel; Ploidies; Sarcoma; Staurosporine; Tumor Cells, Cultured | 2001 |
Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase enhances chemotherapeutic effects on H460 human non-small cell lung cancer cells through activation of apoptosis.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Butadienes; Carcinoma, Non-Small-Cell Lung; Caspases; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Paclitaxel; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase C; Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein | 2003 |
Antisense BAG-1 sensitizes HeLa cells to apoptosis by multiple pathways.
Topics: Antineoplastic Agents; Antisense Elements (Genetics); Apoptosis; Carrier Proteins; Cell Survival; Cytochromes c; DNA-Binding Proteins; Down-Regulation; Drug Resistance; Fenretinide; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Paclitaxel; Signal Transduction; Staurosporine; Transcription Factors; Transfection; Tretinoin | 2003 |
Glycogen synthase kinase-3 regulates cytoskeleton and translocation of Rac1 in long cellular extensions of human keratinocytes.
Topics: Aminophenols; Cells, Cultured; Colchicine; Cytochalasin D; Cytoskeleton; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Humans; Keratinocytes; Lithium Chloride; Maleimides; Nocodazole; Nucleic Acid Synthesis Inhibitors; Paclitaxel; Pseudopodia; rac1 GTP-Binding Protein; Staurosporine | 2004 |
Characterization of aurora-a in porcine oocytes and early embryos implies its functional roles in the regulation of meiotic maturation, fertilization and cleavage.
Topics: Animals; Aurora Kinases; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Cleavage Stage, Ovum; Colchicine; Embryo, Mammalian; Female; Fertilization in Vitro; Meiosis; Microtubules; Mitosis; Oocytes; Paclitaxel; Protein Kinases; Protein Serine-Threonine Kinases; Spindle Apparatus; Staurosporine; Subcellular Fractions; Swine; Xenopus Proteins | 2005 |
Antitumor and normal cell protective effect of PKC412 in the athymic mouse model of ovarian cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Cytokines; Drug Therapy, Combination; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Protein Kinase C; Spleen; Staurosporine; Xenograft Model Antitumor Assays | 2006 |
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.
Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; beta Catenin; Caspase 3; Cell Cycle Proteins; Cell Line, Tumor; Chromatin; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Fibroblasts; HCT116 Cells; Histones; Humans; Intestinal Mucosa; Intestines; Mice; Mice, Transgenic; Mitosis; Models, Biological; Nocodazole; Paclitaxel; Polyploidy; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Small Interfering; Spindle Apparatus; Staurosporine | 2007 |
FLIM and emission spectral analysis of caspase-3 activation inside single living cell during anticancer drug-induced cell death.
Topics: Antineoplastic Agents; Bufanolides; Caspase 3; Cell Death; Cell Line, Tumor; Cell Survival; Enzyme Activation; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Fluorescence, Multiphoton; Paclitaxel; Photobleaching; Staurosporine | 2009 |
[Expression of connexin 43 in ovarian cancer and its relationship with chemoresistance].
Topics: Adult; Aged; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Connexin 43; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Gap Junctions; Humans; Immunohistochemistry; Middle Aged; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Protein Kinase C; Staurosporine; Transfection | 2009 |
Mitochondrial DNA depletion promotes impaired oxidative status and adaptive resistance to apoptosis in T47D breast cancer cells.
Topics: Adenosine Triphosphate; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Catalase; DNA, Mitochondrial; Doxorubicin; Enzyme Inhibitors; fas Receptor; Female; Glutathione Peroxidase; Humans; L-Lactate Dehydrogenase; Lactic Acid; Mitochondria; Oxidative Stress; Oxygen Consumption; Paclitaxel; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Superoxide Dismutase; Tumor Cells, Cultured; Vincristine | 2009 |
Characterization of the transcriptional signature of C/EBPbeta isoforms (LAP/LIP) in Hep3B cells: implication of LIP in pro-survival functions.
Topics: Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Protein-beta; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Profiling; Genetic Engineering; Humans; Liver Neoplasms; Models, Biological; Oligonucleotide Array Sequence Analysis; Paclitaxel; Protein Isoforms; Staurosporine; Transcription, Genetic | 2011 |
Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Etoposide; Fluorescent Antibody Technique; Humans; Hyaluronan Receptors; Immunoblotting; Male; Mice; Mice, SCID; Neoplastic Stem Cells; Paclitaxel; Retinoblastoma-Binding Protein 2; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine | 2011 |
Individual dose and scheduling determine the efficacy of combining cytotoxic anticancer agents with a kinase inhibitor in non-small-cell lung cancer.
Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Antagonism; Drug Synergism; Etoposide; Humans; Immunoblotting; Lung Neoplasms; Paclitaxel; Protein Kinase C; Signal Transduction; Staurosporine; Time Factors | 2012 |
G2 checkpoint abrogator abates the antagonistic interaction between antimicrotubule drugs and radiation therapy.
Topics: Analysis of Variance; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Breast Neoplasms; Cell Death; Cell Division; Cell Line, Tumor; Chemoradiotherapy; DNA Fragmentation; Female; Flow Cytometry; G2 Phase Cell Cycle Checkpoints; Humans; Microtubules; Paclitaxel; Prohibitins; Radiation, Ionizing; Staurosporine; Tumor Cells, Cultured; Vincristine | 2012 |
Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Genes, p53; Humans; Paclitaxel; Plasmids; Prions; Retroviridae; RNA, Small Interfering; Signal Transduction; Staurosporine; Trypan Blue | 2012 |
Effects of paclitaxel on permanent head and neck squamous cell carcinoma cell lines and identification of anti-apoptotic caspase 9b.
Topics: Alternative Splicing; Antineoplastic Agents, Phytogenic; Apoptotic Protease-Activating Factor 1; Carcinoma, Squamous Cell; Caspase 9; Cell Cycle; Cell Death; Cell Line, Tumor; DNA Methylation; Enzyme Activation; Head and Neck Neoplasms; Humans; Membrane Potential, Mitochondrial; Paclitaxel; Promoter Regions, Genetic; Squamous Cell Carcinoma of Head and Neck; Staurosporine | 2016 |
Caspase-mediated cleavage of X-ray repair cross-complementing group 4 promotes apoptosis by enhancing nuclear translocation of caspase-activated DNase.
Topics: Animals; Apoptosis; Cell Nucleus; Deoxyribonucleases; DNA Fragmentation; DNA Repair; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Mice; Neoplasms; Paclitaxel; Protein Serine-Threonine Kinases; Serine-Arginine Splicing Factors; Signal Transduction; Staurosporine; Vincristine | 2018 |