paclitaxel and mac321
paclitaxel has been researched along with mac321 in 5 studies
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Annable, T; Beyer, C; Discafani, CM; Gallagher, P; Greenberger, LM; Liu, H; Loganzo, F; Musto, S; Rios, C; Sampath, D; Tan, X | 1 |
| Annable, T; Greenberger, LM; Hari, M; Loganzo, F; Morilla, DB; Musto, S; Nettles, JH; Snyder, JP; Tan, X | 1 |
| Appleman, L; Bukowski, R; Cooper, W; Grover, J; Lockhart, AC; Mayer, PR; Rothenberg, ML; Shapiro, M; Wang, KK; Zhu, AX | 1 |
| Berg, D; Bernard, S; Brescia, F; Cohn, A; Frenette, G; Hochster, H; Lockhart, AC; Macdonald, J; Melin, S; Picus, J; Raftopoulos, H; Ramanathan, RK | 1 |
| Bielawski, M; Connolly, P; Safarpour, H; Tong, X; Wilcox, E | 1 |
Trials
2 trial(s) available for paclitaxel and mac321
| Article | Year |
|---|---|
Phase I trial of oral MAC-321 in subjects with advanced malignant solid tumors.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Dose-Response Relationship, Drug; Female; Fever; Half-Life; Humans; Male; Middle Aged; Neoplasms; Neutropenia; Paclitaxel; Treatment Outcome | 2007 |
A phase II study of milataxel: a novel taxane analogue in previously treated patients with advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Blood Cell Count; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Middle Aged; Paclitaxel; Treatment Failure | 2008 |
Other Studies
3 other study(ies) available for paclitaxel and mac321
| Article | Year |
|---|---|
MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Division; Docetaxel; Female; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Microtubules; Neoplasms, Experimental; Paclitaxel; Taxoids; Tubulin; Tumor Cells, Cultured | 2003 |
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents, Phytogenic; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Line, Tumor; Docetaxel; Drug Resistance, Neoplasm; Epothilones; Glutamic Acid; Humans; Mice; Mice, Nude; Microtubules; Paclitaxel; Point Mutation; Protein Conformation; Taxoids; Tubulin; Verapamil | 2006 |
Overcoming extractability hurdles of a 14C labeled taxane analogue milataxel and its metabolite from xenograft mouse tumor and brain tissues.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Brain; Cell Line, Tumor; Female; Hexanes; Humans; Injections, Intravenous; Methanol; Mice; Mice, Nude; Paclitaxel; Solvents; Transplantation, Heterologous | 2009 |