Page last updated: 2024-08-23

paclitaxel and carbamates

paclitaxel has been researched along with carbamates in 73 studies

Research

Studies (73)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (9.59)	18.7374
1990's	11 (15.07)	18.2507
2000's	36 (49.32)	29.6817
2010's	16 (21.92)	24.3611
2020's	3 (4.11)	2.80

Authors

Authors	Studies
Albertini, DF; Clark, JI	1
Cleveland, DW; Kirschner, MW; Lopata, MA; Sherline, P	1
De Brabander, M; De Mey, J; Geuens, G; Nuydens, R; Willebrords, R	2
Borisy, GG; Bulinski, JC; De Brabander, M; De Mey, J; Geuens, G	1
Hamel, E; Lin, CM	1
Anderson, M; Flanagan, DJ; Warr, JR	1
Braguer, D; Briand, C; Carles, G; Garcia, P	2
Judson, IR; Kelland, LR; Raynaud, FI; Walton, MI	1
Day, BW; Gunasekera, SP; Hamel, E; Kowalski, RJ; Lin, CM; Longley, RE; Rosenkranz, HS; ter Haar, E	1
Chen, J; Hung, DT; Schreiber, SL	1
Service, RF	1
Day, BW; Giannakakou, P; Gunasekera, SP; Hamel, E; Kowalski, RJ; Longley, RE	1
Balachandran, R; Day, BW; Grant, SG; ter Haar, E; Welsh, MJ	1
Chakravarty, S; Danishefsky, SJ; He, L; Horwitz, SB; Inoue, T; Kuduk, SD; Lin, S; Ojima, I	1
Fojo, T; Giannakakou, P	1
Arimoto, H; Danishefsky, SJ; Horwitz, SB; Kaufman, MD; Martello, LA; McDaid, HM; Meng, D; Pettus, TR; Regl, DL; Smith, AB; Yang, CP	1
Brunner, D; Nurse, P	1
Adler, AJ; Crabtree, DV; Geng, X; Ojima, I	1
Godbole, R; Nick, P; Wang, QY	1
Choy, YH; Lee, JS; Park, YH	1
Beauchamp, TJ; He, L; Horwitz, SB; LaMarche, MJ; Martello, LA; Smith, AB	1
Albrecht, C; Busscher, GF; de Bruijn, P; de Groot, FM; Koekkoek, R; Loos, WJ; Scheeren, HW; Seelen, AE; van Berkom, LW	1
Kalesse, M	1
Chen, JG; Horwitz, SB	1
Adler, ID; Baumgartner, A; Schmid, TE	1
Balachandran, R; Curran, DP; Day, BW; Giuliano, KA; Madiraju, C; Minguez, JM	1
Hu, W; Li, YZ; Zhou, L	1
Balachandran, R; Choy, N; Curran, DP; Day, BW; Madiraju, C; Nguyen, PQ; Shin, Y	1
Braguer, D; Briand, C; Honore, S; Jordan, MA; Kamath, K; Wilson, L	1
Bröker, LE; Giaccone, G; Huisman, C; Kruyt, FA; Rodriguez, JA; Span, SW	1
Dabydeen, DA; Florence, GJ; Hamel, E; Paterson, I	1
Braguer, D; Briand, C; Honore, S; Horwitz, SB; Jordan, MA; Kamath, K; Wilson, L	1
Freeze, BS; Horwitz, SB; Klein, LE; Smith, AB	1
Aspland, SE; Ballatore, C; Castellino, AJ; Castillo, R; Desharnais, J; Eustaquio, T; Smith, AB; Sun, C	1
Horwitz, SB; Huang, H; Kalpana, G; Liu, W; Mani, S; Smith, AB; Sundarababu, S	1
Backman, JT; Kajosaari, LI; Laitila, J; Neuvonen, PJ	1
Balachandran, R; Brückner, AM; Curran, DP; Day, BW; Edler, MC; Fournier, JH; Fukui, Y; Giuliano, KA; Hamel, E; Madiraju, C; Raccor, BS; Shin, Y; Vogt, A; Zhu, G	1
Freeze, BS; Goldberg, GL; Horwitz, SB; Huang, GS; Lopez-Barcons, L; McDaid, HM; Smith, AB	1
Horwitz, SB; Kenesky, CS; Orr, GA; Rucker, PV; Smith, AB; Xia, S	1
Andreu, JM; Barasoain, I; Buey, RM; Calvo, E; Cerezo, G; Day, BW; Díaz, JF; Edler, MC; Hamel, E; López, JA; Matesanz, R; Pineda, O; Sorensen, EJ; Vanderwal, CD	1
Ballatore, C; Deiches, RF; Huryn, D; Hyde, E; Lee, VM; Smith, AB; Trojanowski, JQ	1
Horwitz, SB; Wiesen, KM; Xia, S; Yang, CP	1
Backman, JT; Ingelman-Sundberg, M; Kajosaari, LI; Neuvonen, PJ; Niemi, M; Robledo, M; Rodríguez-Antona, C	1
Itoh, Y; Kouketsu, A; Maeda, S; Miyata, N; Nakagawa, H; Suzuki, N; Suzuki, T; Yoshida, M	1
Balachandran, R; Curran, DP; Day, BW; Fukui, Y; Jung, WH; Madiraju, C; Montgomery, K; Raccor, BS; Shin, Y; Sikorski, RP; Vogt, A	1
Mooberry, SL	1
Naylor, GJ; Paterson, I; Wright, AE	1
Ballatore, C; Lee, VM; Smith, AB; Trojanowski, JQ; Zhang, B	1
Gardner, NM; Guzmán, E; Paterson, I; Wright, AE	1
Altmann, KH; Gertsch, J; Meier, S; Müller, M	1
Alcaraz, AA; Bane, S; Banerjee, A; Chen, QH; Hodge, M; Kingston, DG; Loew, M; Sharma, S; Snyder, JP	1
Angeletti, RH; Fiser, A; Horwitz, SB; Khrapunovich-Baine, M; Menon, V; Smith, AB; Verdier-Pinard, P; Xiao, H	1
Fujita, T; Guzmán, E; Naylor, GJ; Paterson, I; Wright, AE	1
Goldberg, GL; Horwitz, SB; Shahabi, S; Yang, CP	1
Brouwer-Visser, J; Chao, SK; Horwitz, SB; Lin, J; McDaid, HM; Smith, AB	1
Gardner, NM; Guzmán, E; Naylor, GJ; Paterson, I; Wright, AE	1
Andreu, JM; Canales, A; Coderch, C; Díaz, JF; Jiménez-Barbero, J; Nieto, L; Paterson, I; Rodríguez-Salarichs, J; Trigili, C	1
Foti, RS; Rock, DA; VandenBrink, BM; Wahlstrom, JL; Wienkers, LC	1
Bane, S; Blanden, AR; Kingston, DG; Qi, J	1
Atasoylu, O; Horwitz, SB; Smith, AB; Sugasawa, K; Yang, CP	1
Ma, L; Shi, D; Yu, L; Zeng, S; Zhou, Q	1
Blanco, MD; Martínez, A; Pérez, E; Teijón, C; Teijón, JM	1
Goldman, ID; Horwitz, SB	1
Li, J; Lu, J; Wang, M; Wang, Y; Xu, Y; Zhang, H; Zhou, D	1
Basavanna, LN; Karuppasamy, R; Sequeira, VM; Veerappapillai, S; Verma, K	1
Atasoylu, O; Horwitz, SB; McDaid, HM; Nadaradjane, C; Rodriguez-Gabin, A; Smith, AB; Sugasawa, K; Yang, CH; Ye, K	1
Dang, D; Frost, JA; Li, J; Li, L; Yang, Q; Zuo, Y	1
Hohmann, AG; Mali, SS; Slivicki, RA; Xu, Z	1
Ahlström, H; Botling, J; Dahlstrand, H; Koliadi, A; Öberg, K; Tholander, B; Ullenhag, GJ; Von Heideman, A	1
Pan, X; Wang, G; Xiao, Y; Zhang, X	1
Peng, Y; Ran, R; Wang, J; Xiao, Y; Zhang, X	1

Reviews

3 review(s) available for paclitaxel and carbamates

Article	Year
The chemistry and biology of discodermolide. Chembiochem : a European journal of chemical biology, 2000, Oct-02, Volume: 1, Issue:3 Topics: Alkanes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carbamates; Lactones; Molecular Conformation; Molecular Structure; Paclitaxel; Pyrones; Stereoisomerism	2000
[Natural anti-tumor compounds with activity of promoting microtubule assembly]. Yao xue xue bao = Acta pharmaceutica Sinica, 2001, Volume: 36, Issue:2 Topics: Alkaloids; Alkanes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carbamates; Diterpenes; Lactones; Macrolides; Materia Medica; Microtubules; Molecular Structure; Paclitaxel; Pyrones; Structure-Activity Relationship; Taxoids	2001
Strategies for the development of novel Taxol-like agents. Methods in molecular medicine, 2007, Volume: 137 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Docetaxel; Drug Design; Drug Resistance, Neoplasm; Epothilones; Humans; Lactones; Microtubules; Paclitaxel; Pyrones; Taxoids	2007

Other Studies

70 other study(ies) available for paclitaxel and carbamates

Article	Year
Visualization of assembled and disassembled microtubule protein by double label fluorescence microscopy. Cell biology international reports, 1981, Volume: 5, Issue:4 Topics: Animals; Antibodies; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Benzimidazoles; Carbamates; Colchicine; Female; Granulosa Cells; Microtubules; Nocodazole; Paclitaxel; Rats; Terpenes; Tubulin	1981
Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell, 1981, Volume: 25, Issue:2 Topics: Alkaloids; Animals; Benzimidazoles; Carbamates; Cell Line; Colchicine; Cricetinae; Drosophila; Kinetics; Mice; Nocodazole; Paclitaxel; Polymers; RNA, Messenger; Tubulin; Vinblastine	1981
Microtubule assembly in living cells after release from nocodazole block: the effects of metabolic inhibitors, taxol and PH. Cell biology international reports, 1981, Volume: 5, Issue:9 Topics: Alkaloids; Animals; Azides; Benzimidazoles; Carbamates; Cell Line; Hydrogen-Ion Concentration; Kidney; Marsupialia; Microtubules; Nocodazole; Paclitaxel	1981
Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochores. Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:9 Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Benzimidazoles; Carbamates; Cells, Cultured; Centrioles; Centromere; Chromosomes; Humans; Mice; Microtubules; Mitosis; Nocodazole; Organoids; Paclitaxel; Protein Binding; Tubulin	1981
Immunoelectron microscopic localization of the 210,000-mol wt microtubule-associated protein in cultured cells of primates. The Journal of cell biology, 1981, Volume: 91, Issue:2 Pt 1 Topics: Alkaloids; Animals; Azides; Benzimidazoles; Carbamates; Cell Line; Centrioles; Chlorocebus aethiops; Cytoskeleton; Humans; Immunoenzyme Techniques; Interphase; Macropodidae; Mice; Microscopy, Electron; Microtubule-Associated Proteins; Microtubules; Mitosis; Nocodazole; Paclitaxel; Proteins; Sodium Azide; Vinblastine	1981
Interactions of a new antimitotic agent, NSC-181928, with purified tubulin. Biochemical and biophysical research communications, 1982, Feb-11, Volume: 104, Issue:3 Topics: Alkaloids; Animals; Benzimidazoles; Carbamates; Cattle; Colchicine; Guanosine Triphosphate; Hydrolysis; Nocodazole; Paclitaxel; Polymers; Pyrazines; Temperature; Tubulin	1982
Mutants of Chinese hamster ovary cells with altered sensitivity to taxol and benzimidazole carbamates. Cell biology international reports, 1982, Volume: 6, Issue:5 Topics: Alkaloids; Animals; Benzimidazoles; Carbamates; Cell Line; Colchicine; Cricetinae; Demecolcine; Drug Resistance; Female; Griseofulvin; Mutation; Ovary; Paclitaxel; Polysorbates	1982
Simultaneous combination of microtubule depolymerizing and stabilizing agents acts at low doses. Anti-cancer drugs, 1995, Volume: 6, Issue:4 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carbamates; Cell Division; Colchicine; Demecolcine; Docetaxel; Humans; KB Cells; Microscopy, Fluorescence; Microscopy, Immunoelectron; Microtubule Proteins; Microtubules; Paclitaxel; Pyrazines; Pyridines; Taxoids; Tubulin	1995
[Effect of the association of antimitotic agents on cell lines of human adenocarcinoma]. Bulletin du cancer, 1994, Volume: 81, Issue:10 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carbamates; Colonic Neoplasms; Docetaxel; Humans; Paclitaxel; Pyrazines; Pyridines; Skin Neoplasms; Taxoids; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Vinblastine; Vinorelbine	1994
Preclinical pharmacology of 1069C85, a novel tubulin binder. Cancer chemotherapy and pharmacology, 1994, Volume: 35, Issue:2 Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Carbamates; Chromatography, High Pressure Liquid; Doxorubicin; Female; Humans; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Paclitaxel; Pyridazines; Tissue Distribution; Tubulin; Tumor Cells, Cultured; Vinblastine	1994
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry, 1996, Jan-09, Volume: 35, Issue:1 Topics: Alkanes; Animals; Antineoplastic Agents; Breast Neoplasms; Burkitt Lymphoma; Calcium; Carbamates; Cell Division; Cell Line; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique, Indirect; Guanosine Triphosphate; Humans; Kinetics; Lactones; Microscopy, Electron; Microtubule-Associated Proteins; Microtubules; Paclitaxel; Porifera; Pyrones; Time Factors; Tubulin; Tumor Cells, Cultured	1996
(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chemistry & biology, 1996, Volume: 3, Issue:4 Topics: 3T3 Cells; Alkanes; Animals; Binding Sites; Carbamates; Cell Line; Humans; Lactones; Mice; Microtubules; Mitosis; Paclitaxel; Pyrones	1996
Tumor-killer made; how does it work? Science (New York, N.Y.), 1996, Dec-20, Volume: 274, Issue:5295 Topics: Alkanes; Antineoplastic Agents; Carbamates; Computer Simulation; Epothilones; Epoxy Compounds; Lactones; Microtubules; Models, Molecular; Molecular Conformation; Paclitaxel; Pyrones; Thiazoles; Tumor Cells, Cultured	1996
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Molecular pharmacology, 1997, Volume: 52, Issue:4 Topics: Alkanes; Animals; Antineoplastic Agents, Phytogenic; Binding, Competitive; Carbamates; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique, Indirect; Humans; Lactones; Microscopy, Electron; Microtubules; Ovarian Neoplasms; Paclitaxel; Pyrones; Rats; Tubulin; Tumor Cells, Cultured	1997
The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells--preliminary comparisons to paclitaxel. Anti-cancer drugs, 1998, Volume: 9, Issue:1 Topics: Alkanes; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carbamates; Diploidy; DNA Fragmentation; DNA, Neoplasm; Female; Humans; Lactones; Paclitaxel; Pyrones; Tumor Cells, Cultured	1998
A common pharmacophore for cytotoxic natural products that stabilize microtubules. Proceedings of the National Academy of Sciences of the United States of America, 1999, Apr-13, Volume: 96, Issue:8 Topics: Alkaloids; Alkanes; Antineoplastic Agents, Phytogenic; Carbamates; Computer Graphics; Diterpenes; Epothilones; Epoxy Compounds; Lactones; Magnetic Resonance Spectroscopy; Microtubules; Models, Molecular; Molecular Conformation; Molecular Structure; Paclitaxel; Pyrones; Thiazoles	1999
Discodermolide: just another microtubule-stabilizing agent? No! A lesson in synergy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:5 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Drug Synergism; Humans; Lactones; Lung Neoplasms; Microtubules; Paclitaxel; Pyrones; Tumor Cells, Cultured	2000
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:5 Topics: Alkaloids; Alkanes; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Carbamates; Cell Count; Cell Division; Cell Line; Cytoskeleton; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Epothilones; Epoxy Compounds; Flow Cytometry; Humans; Lactones; Lung Neoplasms; Microtubules; Mitosis; Paclitaxel; Pyrones; Thiazoles; Tumor Cells, Cultured	2000
CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast. Cell, 2000, Sep-01, Volume: 102, Issue:5 Topics: Benzimidazoles; Carbamates; Carrier Proteins; Cell Polarity; Cloning, Molecular; Fluorescent Antibody Technique; Fungal Proteins; Gene Deletion; Genes, Fungal; Glycoproteins; Heat-Shock Proteins; Intermediate Filament Proteins; Kinetics; Microtubule-Associated Proteins; Microtubules; Neoplasm Proteins; Paclitaxel; Phenotype; Protein Binding; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sequence Homology, Amino Acid	2000
Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:8 Topics: Alkaloids; Alkanes; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Carbamates; Carotenoids; Diterpenes; Epothilones; Epoxy Compounds; Haplorhini; Humans; Lactones; Ligands; Lutein; Models, Molecular; Molecular Sequence Data; Paclitaxel; Pyrones; Retina; Thiazoles; Tubulin	2001
Probing rice gravitropism with cytoskeletal drugs and cytoskeletal mutants. The Biological bulletin, 1997, Volume: 192, Issue:1 Topics: Actin Cytoskeleton; Actins; Carbamates; Cell Polarity; Colchicine; Cotyledon; Cytochalasin D; Cytoskeleton; Dinitrobenzenes; Gravitropism; Gravity Sensing; Herbicides; Microtubules; Mutation; Nucleic Acid Synthesis Inhibitors; Oryza; Paclitaxel; Phenylcarbamates; Plastids; Sulfanilamides; Tubulin; Urethane	1997
The effect of taxol and ethyl-N-phenylcarbamate (EPC) on growth and gravitropism in Zea mays L. Singmul Hakhoe chi. The Korean journal of botany, 1996, Volume: 39, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Biological Transport; Carbamates; Gravitropism; Indoleacetic Acids; Microtubules; Paclitaxel; Phenylcarbamates; Plant Roots; Urethane; Zea mays	1996
The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies. Chemistry & biology, 2001, Volume: 8, Issue:9 Topics: Alkanes; Antineoplastic Agents, Phytogenic; Binding, Competitive; Carbamates; Flow Cytometry; Humans; Inhibitory Concentration 50; Lactones; Microscopy, Electron; Microscopy, Fluorescence; Microtubules; Models, Molecular; Paclitaxel; Pyrones; Stereoisomerism; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	2001
Elongated multiple electronic cascade and cyclization spacer systems in activatible anticancer prodrugs for enhanced drug release. The Journal of organic chemistry, 2001, Dec-28, Volume: 66, Issue:26 Topics: Antineoplastic Agents; Carbamates; Cyclization; Doxorubicin; Drug Screening Assays, Antitumor; Electrons; Fibrinolysin; Humans; Hydrolysis; Indicators and Reagents; Kinetics; Oligopeptides; Paclitaxel; Prodrugs; Structure-Activity Relationship; Tumor Cells, Cultured	2001
Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs. Cancer research, 2002, Apr-01, Volume: 62, Issue:7 Topics: Alkanes; Aneuploidy; Antineoplastic Agents; Carbamates; Carcinoma, Non-Small-Cell Lung; Epothilones; Humans; Lactones; Lung Neoplasms; Macrolides; Microtubules; Mitosis; Paclitaxel; Pyrones; Spindle Apparatus; Tumor Cells, Cultured	2002
Induction of aneuploidy in male mouse germ cells detected by the sperm-FISH assay: a review of the present data base. Mutation research, 2002, Jul-25, Volume: 504, Issue:1-2 Topics: Acrylamide; Aneuploidy; Animals; Benzimidazoles; Carbamates; Colchicine; Diazepam; Griseofulvin; Humans; In Situ Hybridization, Fluorescence; Male; Meiosis; Mice; Mice, Inbred C3H; Omeprazole; Paclitaxel; Spermatozoa; Substance-Related Disorders; Thiabendazole; Trichlorfon; Vinblastine	2002
Synthesis and high content cell-based profiling of simplified analogues of the microtubule stabilizer (+)-discodermolide. Molecular cancer therapeutics, 2002, Volume: 1, Issue:14 Topics: Alkanes; Antineoplastic Agents; Binding Sites; Carbamates; Carbon; Carcinoma; Cell Division; Dose-Response Relationship, Drug; Gene Library; HeLa Cells; Humans; Lactones; Microtubules; Models, Chemical; Paclitaxel; Phosphorylation; Pyrones; Signal Transduction; Spindle Apparatus; Tubulin; Tumor Cells, Cultured	2002
Simplified discodermolide analogues: synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents. Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14 Topics: Alkanes; Animals; Antineoplastic Agents; Binding Sites; Binding, Competitive; Carbamates; Cattle; Cell Division; Crystallography, X-Ray; Lactones; Microtubules; Paclitaxel; Pyrones; Stereoisomerism; Structure-Activity Relationship; Tubulin	2003
Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation. Molecular cancer therapeutics, 2003, Volume: 2, Issue:12 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Division; Cell Line, Tumor; Epothilones; Humans; Lactones; Microtubules; Mitosis; Paclitaxel; Pyrones	2003
Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells. Cancer research, 2004, Jan-01, Volume: 64, Issue:1 Topics: Alkanes; Antineoplastic Agents; Apoptosis; Base Sequence; Carbamates; Carcinoma, Non-Small-Cell Lung; Caspases; Cathepsin B; Cell Death; DNA Primers; Epothilones; Humans; Lactones; Lung Neoplasms; Lysosomes; Microscopy, Fluorescence; Microtubules; Paclitaxel; Pyrones; Transfection; Tumor Cells, Cultured	2004
A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel. Cancer chemotherapy and pharmacology, 2004, Volume: 53, Issue:5 Topics: Alkanes; Carbamates; Dose-Response Relationship, Drug; Epothilones; Guanosine Triphosphate; Lactones; Microtubule-Associated Proteins; Microtubules; Paclitaxel; Polymers; Pyrones; Tubulin; Tubulin Modulators	2004
Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer research, 2004, Jul-15, Volume: 64, Issue:14 Topics: Alkanes; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Binding Sites; Carbamates; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Synergism; G2 Phase; Humans; Inhibitory Concentration 50; Lactones; Lung Neoplasms; Microtubules; Mitosis; Paclitaxel; Pyrones	2004
The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell cycle (Georgetown, Tex.), 2005, Volume: 4, Issue:3 Topics: Alkanes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Bromodeoxyuridine; Carbamates; Cell Line, Tumor; Cellular Senescence; Flow Cytometry; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Lactones; Microtubules; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitosis; Paclitaxel; Phenotype; Pyrones; Signal Transduction; Time Factors	2005
A facile route to paclitaxel C-10 carbamates. Bioorganic & medicinal chemistry letters, 2005, May-16, Volume: 15, Issue:10 Topics: Carbamates; Paclitaxel	2005
Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Sep-01, Volume: 11, Issue:17 Topics: Alkanes; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Epothilones; Glutathione Transferase; Histone Acetyltransferases; Humans; Immunoblotting; Lactones; Mice; Mice, Inbred C57BL; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Co-Repressor 2; Nuclear Receptor Coactivator 1; Oxidoreductases, N-Demethylating; Paclitaxel; Plasmids; Pregnane X Receptor; Pyrones; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reflex, Abnormal; Repressor Proteins; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Two-Hybrid System Techniques; Xenobiotics	2005
Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin. Basic & clinical pharmacology & toxicology, 2005, Volume: 97, Issue:4 Topics: Aryl Hydrocarbon Hydroxylases; Bezafibrate; Carbamates; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fenofibrate; Gemfibrozil; Humans; Hypoglycemic Agents; In Vitro Techniques; Itraconazole; Microsomes, Liver; Midazolam; Paclitaxel; Piperidines; Quercetin; Rifampin	2005
Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry, 2005, Nov-15, Volume: 44, Issue:45 Topics: Alkanes; Antineoplastic Agents; Binding Sites; Carbamates; Cell Line, Tumor; Cell Proliferation; Humans; Lactones; Macrolides; Microscopy, Fluorescence; Microtubules; Paclitaxel; Pyrones; Tubulin	2005
Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Jan-01, Volume: 12, Issue:1 Topics: Alkanes; Animals; Antineoplastic Combined Chemotherapy Protocols; Carbamates; Caspases; Cell Cycle; Cell Line, Tumor; Drug Synergism; Enzyme Activation; Female; Humans; Immunohistochemistry; Lactones; Mice; Neovascularization, Pathologic; Ovarian Neoplasms; Paclitaxel; Platelet Endothelial Cell Adhesion Molecule-1; Pyrones; Xenograft Model Antitumor Assays	2006
A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin. Biochemistry, 2006, Oct-03, Volume: 45, Issue:39 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Division; G2 Phase; Humans; Lactones; Microtubules; Models, Molecular; Paclitaxel; Peptides; Photoaffinity Labels; Protein Binding; Protein Structure, Tertiary; Pyrones; Tubulin	2006
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. Nature chemical biology, 2007, Volume: 3, Issue:2 Topics: Alkanes; Amino Acid Sequence; Asparagine; Binding Sites; Binding, Competitive; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Docetaxel; Epothilones; Humans; Inhibitory Concentration 50; Lactones; Mass Spectrometry; Microtubules; Models, Chemical; Models, Molecular; Molecular Sequence Data; Paclitaxel; Polycyclic Compounds; Protein Binding; Pyrones; Taxoids; Threonine; Tubulin; Tubulin Modulators	2007
Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies. Bioorganic & medicinal chemistry letters, 2007, Jul-01, Volume: 17, Issue:13 Topics: Animals; Blood-Brain Barrier; Brain; Carbamates; Chemistry, Pharmaceutical; Drug Design; Humans; Mice; Models, Chemical; Neurodegenerative Diseases; Paclitaxel; Permeability; Tauopathies; Time Factors	2007
Wild-type class I beta-tubulin sensitizes Taxol-resistant breast adenocarcinoma cells harboring a beta-tubulin mutation. Cancer letters, 2007, Nov-18, Volume: 257, Issue:2 Topics: Adenocarcinoma; Alkanes; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carbamates; Cell Line, Tumor; Cell Survival; Dimerization; Docetaxel; Drug Resistance, Neoplasm; Epothilones; Fluorescent Antibody Technique, Indirect; Glutamic Acid; Glycine; Humans; Lactones; Models, Molecular; Mutation, Missense; Paclitaxel; Protein Structure, Quaternary; Pyrones; Taxoids; Transfection; Tubulin; Tubulin Modulators	2007
Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism. The pharmacogenomics journal, 2008, Volume: 8, Issue:4 Topics: Aryl Hydrocarbon Hydroxylases; Carbamates; Cytochrome P-450 CYP2C8; Genetic Variation; Haplotypes; Humans; Paclitaxel; Piperidines; White People	2008
Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. Journal of medicinal chemistry, 2007, Nov-01, Volume: 50, Issue:22 Topics: Antineoplastic Agents; Carbamates; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Drug Synergism; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Paclitaxel; Stereoisomerism; Structure-Activity Relationship	2007
Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin. Molecular pharmacology, 2008, Volume: 73, Issue:3 Topics: Alkanes; Animals; Benzimidazoles; Binding Sites; Brain Chemistry; Carbamates; Carcinoma; Cattle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Epothilones; Female; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; G2 Phase; HeLa Cells; Histones; Humans; Kinetics; Lactones; Macrolides; Microtubules; Molecular Structure; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Protein Binding; Pyrones; Quantitative Structure-Activity Relationship; Radioligand Assay; Tubulin; Tubulin Modulators	2008
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide. Chemical communications (Cambridge, England), 2008, Oct-14, Issue:38 Topics: Alkanes; Antineoplastic Agents; Biological Products; Carbamates; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Humans; Lactones; Macrolides; Paclitaxel; Pyrones	2008
In situ blood-brain barrier permeability of a C-10 paclitaxel carbamate. Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbamates; Central Nervous System; Disease Models, Animal; Mice; Molecular Structure; Neurodegenerative Diseases; Paclitaxel; Permeability; Structure-Activity Relationship	2008
Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region. Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lactones; Macrolides; Molecular Structure; Paclitaxel; Porifera; Pyrones; Stereoisomerism; Structure-Activity Relationship; Tubulin	2008
Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide. Chembiochem : a European journal of chemical biology, 2009, Jan-05, Volume: 10, Issue:1 Topics: Alkanes; Animals; Biological Products; Brain; Carbamates; Cell Proliferation; Drug Combinations; Drug Synergism; Epothilones; Humans; Lactones; Microscopy, Electron; Microtubules; Nephelometry and Turbidimetry; Paclitaxel; Protein Multimerization; Protein Structure, Quaternary; Pyrones; Swine; Tubulin; Tubulin Modulators	2009
Synthesis and bioactivity of a side chain bridged paclitaxel: A test of the T-Taxol conformation. Bioorganic & medicinal chemistry letters, 2009, May-15, Volume: 19, Issue:10 Topics: Antineoplastic Agents, Phytogenic; Carbamates; Cell Line, Tumor; Humans; Paclitaxel; Tubulin	2009
Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization. Biochemistry, 2009, Dec-15, Volume: 48, Issue:49 Topics: Alkanes; Animals; Binding Sites; Carbamates; Cattle; Chickens; Deuterium Exchange Measurement; Dimerization; Drug Synergism; Lactones; Microtubules; Paclitaxel; Peptide Fragments; Protein Binding; Protein Isoforms; Protein Stability; Pyrones; Tubulin; Tubulin Modulators	2009
Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin. Chemical communications (Cambridge, England), 2010, Jan-14, Volume: 46, Issue:2 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Humans; Lactones; Macrolides; Microtubules; Paclitaxel; Pyrones; Tubulin Modulators	2010
Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells. Gynecologic oncology, 2010, Volume: 119, Issue:2 Topics: Acetylation; Alkanes; Antigens, Neoplasm; Carbamates; Cell Adhesion Molecules; Cell Line, Tumor; Epithelial Cell Adhesion Molecule; Epothilones; Female; Humans; Hydroxamic Acids; Lactones; Ovarian Neoplasms; Paclitaxel; Pyrones; Tubulin; Tubulin Modulators; Vinblastine	2010
Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent. Proceedings of the National Academy of Sciences of the United States of America, 2011, Jan-04, Volume: 108, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Alkanes; Animals; Antineoplastic Agents; beta-Galactosidase; Carbamates; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique; Gene Expression Regulation; Genetic Vectors; Humans; Immunoblotting; Immunohistochemistry; Lactones; Lentivirus; Mice; Microarray Analysis; Paclitaxel; Phosphoproteins; Pyrones; Transduction, Genetic; Tubulin Modulators; Tumor Suppressor Protein p53	2011
Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol. Chemistry, an Asian journal, 2011, Feb-01, Volume: 6, Issue:2 Topics: Alkanes; Antimitotic Agents; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Lactones; Macrolides; Neoplasms; Paclitaxel; Pyrones	2011
Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach. ACS chemical biology, 2011, Aug-19, Volume: 6, Issue:8 Topics: Alkanes; Antineoplastic Agents; Binding Sites; Carbamates; Computer Simulation; Docetaxel; Humans; Lactones; Microtubules; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Paclitaxel; Protein Multimerization; Pyrones; Taxoids; Tubulin; Tubulin Modulators	2011
Evaluation of CYP2C8 inhibition in vitro: utility of montelukast as a selective CYP2C8 probe substrate. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:9 Topics: Acetates; Amodiaquine; Aryl Hydrocarbon Hydroxylases; Binding Sites; Carbamates; Cyclopropanes; Cytochrome P-450 CYP2C8; Drug Interactions; Humans; Microsomes, Liver; Paclitaxel; Piperidines; Quinolines; Rosiglitazone; Sensitivity and Specificity; Substrate Specificity; Sulfides; Thiazolidinediones	2011
Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin. Bioorganic & medicinal chemistry, 2011, Sep-01, Volume: 19, Issue:17 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Drug Design; Fluorescent Dyes; Humans; Lactones; Paclitaxel; Protein Binding; Pyrones; Tubulin	2011
Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity. Journal of medicinal chemistry, 2011, Sep-22, Volume: 54, Issue:18 Topics: Alkanes; Antineoplastic Agents; Binding Sites; Carbamates; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Lactones; Microtubules; Models, Molecular; Molecular Conformation; Paclitaxel; Protein Binding; Pyrones; Solutions; Stereoisomerism; Structure-Activity Relationship; Tubulin	2011
Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharmaceutics & drug disposition, 2013, Volume: 34, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Carbamates; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C8; Cytochromes b5; Genetic Vectors; Genome-Wide Association Study; Humans; Hydroxylation; Hypoglycemic Agents; Ibuprofen; Liver; Paclitaxel; Piperidines; Polymorphism, Genetic	2013
Bioresponsive nanohydrogels based on HEAA and NIPA for poorly soluble drugs delivery. International journal of pharmaceutics, 2014, Aug-15, Volume: 470, Issue:1-2 Topics: Acrylamides; Acrylic Resins; Antineoplastic Agents, Phytogenic; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Survival; Cross-Linking Reagents; Humans; Hydrogels; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; Nanoparticles; Paclitaxel; Polymerization; Solubility; Spectroscopy, Fourier Transform Infrared; Temperature; Thermogravimetry	2014
A conversation with Susan Band Horwitz. Annual review of pharmacology and toxicology, 2015, Volume: 55 Topics: Alkanes; Antineoplastic Agents, Phytogenic; Biomedical Research; Carbamates; Career Choice; Drug Discovery; History, 20th Century; History, 21st Century; Humans; Lactones; Molecular Targeted Therapy; Paclitaxel; Pharmacology; Pyrones; Tubulin Modulators	2015
CYP2C8-mediated interaction between repaglinide and steviol acyl glucuronide: In vitro investigations using rat and human matrices and in vivo pharmacokinetic evaluation in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2016, Volume: 94 Topics: Animals; Carbamates; Chromatography, Liquid; Cytochrome P-450 CYP2C8; Diterpenes, Kaurane; Glucuronides; Humans; Hydroxylation; Male; Microsomes, Liver; Paclitaxel; Piperidines; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry	2016
An Integrative Drug Repurposing Pipeline: Switching Viral Drugs to Breast Cancer. Journal of cellular biochemistry, 2017, Volume: 118, Issue:6 Topics: Anilides; Antineoplastic Agents; Antiviral Agents; Breast Neoplasms; Carbamates; Computational Biology; Drug Repositioning; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Docking Simulation; Mutation; Paclitaxel; Polypharmacology; Proline; Tubulin; Valine	2017
Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners. Journal of natural products, 2018, 03-23, Volume: 81, Issue:3 Topics: Alkanes; Antineoplastic Agents; Carbamates; Dose-Response Relationship, Drug; Humans; Lactones; Microtubules; Paclitaxel; Pyrones; Transcription, Genetic; Tubulin; Tumor Cells, Cultured	2018
Activation of KCNQ Channels Prevents Paclitaxel-Induced Peripheral Neuropathy and Associated Neuropathic Pain. The journal of pain, 2019, Volume: 20, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carbamates; Cell Line, Tumor; Drug Repositioning; Humans; KCNQ Potassium Channels; Male; Neuralgia; Neurons; Neuroprotective Agents; Paclitaxel; Peripheral Nervous System Diseases; Phenylenediamines; Random Allocation; Rats, Sprague-Dawley	2019
Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor Pharmacological research, 2019, Volume: 142 Topics: Amidohydrolases; Analgesics; Animals; Antineoplastic Agents; Benzamides; Benzoxazines; Brain; Cannabinoids; Carbamates; Cell Line, Tumor; Cell Survival; Drug Synergism; Drug Tolerance; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neuralgia; Paclitaxel; Substance-Related Disorders	2019
Complete response with combined BRAF and MEK inhibition in BRAF mutated advanced low-grade serous ovarian carcinoma. Upsala journal of medical sciences, 2020, Volume: 125, Issue:4 Topics: Antineoplastic Agents; Benzimidazoles; Bevacizumab; CA-125 Antigen; Carbamates; Carboplatin; Cystadenocarcinoma, Serous; Disease Progression; Everolimus; Female; High-Throughput Nucleotide Sequencing; Humans; Imidazoles; MAP Kinase Kinase 1; Medroxyprogesterone; Mutation; Neoplasm Metastasis; Neoplasm Recurrence, Local; Ovarian Neoplasms; Oximes; Paclitaxel; Progression-Free Survival; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Recurrence; Sulfonamides; Tamoxifen; Treatment Outcome; Young Adult	2020
FSC231 can alleviate paclitaxel-induced neuralgia by inhibiting PICK1 and affecting related factors. Neuroscience letters, 2021, 01-10, Volume: 741 Topics: Analgesics; Animals; Carbamates; Cell Cycle Proteins; Cinnamates; Ganglia, Spinal; Inflammation Mediators; Male; Mice, Inbred C57BL; Neuralgia; Paclitaxel	2021
FSC231 alleviates paclitaxel-induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK-3β and ERK1/2. Brain and behavior, 2021, Volume: 11, Issue:11 Topics: Animals; Carbamates; Cinnamates; Glycogen Synthase Kinase 3 beta; Neuralgia; Paclitaxel; Rats	2021