Page last updated: 2024-08-23

paclitaxel and caffeine

paclitaxel has been researched along with caffeine in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (18.18)	18.2507
2000's	15 (45.45)	29.6817
2010's	10 (30.30)	24.3611
2020's	2 (6.06)	2.80

Authors

Authors	Studies
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Christensen, C; Deppe, G; Lawrence, WD; Ruan, H; Saunders, DE; Wappler, NL	1
Gu, X; Verma, DP	1
Chau, MS; Hunter, T; Poon, RY; Yamashita, K	1
Boyett, MR; Calaghan, SC; Howarth, FC; White, E	1
Borbé, R; Rieger, J; Weller, M	1
Al-Katib, AA; Aranha, O; Gururajanna, B; Li, YW; Sarkar, FH; Vaitkevicius, VK	1
Gelbard, HA; Jamieson, BD; Planelles, V; Pursell, S; Roshal, M; Zhu, Y	1
Akimoto, T; Kitamoto, Y; Mitsuhashi, N; Nakano, T; Sakurai, H	1
Kim, B; Nghiem, P; Planelles, V; Roshal, M; Zhu, Y	1
Chen, SY; Kussick, SJ; Roberson, RS; Vallieres, E; Wu, DY	1
Bozko, P; Larsen, AK; Sabisz, M; Skladanowski, A	1
Cieslak, J; Ilkevitch, Y; Kuznyetsov, V; Shkumatov, A; Verlinsky, Y	1
Bhat, A; Feng, Z; Gupta, A; Hunt, CR; Jeffery, J; Kaul, SC; Khanna, KK; Kumar, R; Misri, S; Pagan, J; Pandita, RK; Pandita, TK; Parsons, R; Powell, SN; Puc, J; Wadhwa, R; Xiang, T; Yaguchi, T; Yang, Q; Zeng, S	1
Al-Azzam, SI; Alsaad, AA; Alzoubi, KH; Mhaidat, NM	1
Bastola, D; Ghersi, D; Karri, K; Sharma, S; Thapa, I	1
Anoopkumar-Dukie, S; Arora, D; Desbrow, B; Grant, GD; Hall, S; Hong, Y; Lai, R	1
Gan, C; Hu, L; Sheng, J; Shi, B; Wang, L; Wang, X; Wang, Y; Xiang, Z; Xu, H	1
Ali, Q; Arshad, S; Ma, Z; Mustafa, G; Wei, M; Yan, Y	1

Reviews

1 review(s) available for paclitaxel and caffeine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

32 other study(ies) available for paclitaxel and caffeine

Article	Year
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Paclitaxel-induced apoptosis in MCF-7 breast-cancer cells. International journal of cancer, 1997, Jan-17, Volume: 70, Issue:2 Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Caffeine; Cell Cycle; Cisplatin; Cytarabine; DNA Damage; DNA Fragmentation; DNA, Neoplasm; Doxorubicin; Estrogens; Female; Humans; Neoplasms, Hormone-Dependent; Paclitaxel; Tumor Cells, Cultured	1997
Dynamics of phragmoplastin in living cells during cell plate formation and uncoupling of cell elongation from the plane of cell division. The Plant cell, 1997, Volume: 9, Issue:2 Topics: Antibodies; Caffeine; Cell Cycle; Cell Division; Cell Size; Dynamins; Green Fluorescent Proteins; GTP Phosphohydrolases; Luminescent Proteins; Nicotiana; Paclitaxel; Plant Proteins; Plants, Toxic; Protein Conformation	1997
The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer research, 1997, Nov-15, Volume: 57, Issue:22 Topics: 3T3 Cells; Animals; Antineoplastic Agents; Caffeine; CDC2 Protein Kinase; Cyclin A; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Doxorubicin; Electrophoresis, Polyacrylamide Gel; G1 Phase; G2 Phase; Humans; Mice; Mitosis; Nocodazole; Paclitaxel; Phosphorylation; Protein Kinases; Threonine; Tumor Cells, Cultured; Tyrosine	1997
Effect of the microtubule polymerizing agent taxol on contraction, Ca2+ transient and L-type Ca2+ current in rat ventricular myocytes. The Journal of physiology, 1999, Apr-15, Volume: 516 ( Pt 2) Topics: Animals; Antineoplastic Agents, Phytogenic; Caffeine; Calcium Channels; Calcium Channels, L-Type; Calcium Signaling; Colchicine; Depression, Chemical; Electric Stimulation; Heart Ventricles; In Vitro Techniques; Male; Microtubules; Myocardial Contraction; Myocardium; Paclitaxel; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Sarcoplasmic Reticulum	1999
Failure of taxol-based combination chemotherapy for malignant glioma cannot be overcome by G2/M checkpoint abrogators or altering the p53 status. Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Caffeine; G2 Phase; Genes, p53; Glioma; Humans; Mitosis; Paclitaxel; Tumor Cells, Cultured; Virulence Factors, Bordetella	1999
Molecular effects of taxol and caffeine on pancreatic cancer cells. International journal of molecular medicine, 1999, Volume: 4, Issue:5 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Caffeine; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cyclin B; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Flow Cytometry; Humans; Mitochondria; Paclitaxel; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Tumor Suppressor Protein p53	1999
Comparison of cell cycle arrest, transactivation, and apoptosis induced by the simian immunodeficiency virus SIVagm and human immunodeficiency virus type 1 vpr genes. Journal of virology, 2001, Volume: 75, Issue:8 Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Caffeine; Cell Cycle; Chlorocebus aethiops; COS Cells; Flow Cytometry; G2 Phase; Gene Products, vpr; Genes, vpr; HIV Long Terminal Repeat; HIV-1; Humans; Mitosis; Models, Biological; Paclitaxel; Simian Immunodeficiency Virus; Transcriptional Activation; Transduction, Genetic; Tumor Cells, Cultured; vpr Gene Products, Human Immunodeficiency Virus	2001
Caffeine diminishes cytotoxic effects of paclitaxel on a human lung adenocarcinoma cell line. Cancer letters, 2003, Feb-28, Volume: 191, Issue:1 Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Caffeine; Depression, Chemical; Dose-Response Relationship, Drug; G1 Phase; G2 Phase; Humans; Lung Neoplasms; Metaphase; Paclitaxel; Tumor Cells, Cultured; Tumor Stem Cell Assay	2003
Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R. The Journal of biological chemistry, 2003, Jul-11, Volume: 278, Issue:28 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Ataxia Telangiectasia Mutated Proteins; Caffeine; CD4-Positive T-Lymphocytes; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line, Transformed; Chromones; DNA Damage; Doxorubicin; Enzyme Inhibitors; G2 Phase; Gene Products, vpr; Genes, Dominant; Genetic Vectors; HeLa Cells; HIV Infections; Humans; Immunoblotting; Luciferases; Morpholines; Paclitaxel; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; RNA Interference; Signal Transduction; Transfection; vpr Gene Products, Human Immunodeficiency Virus	2003
Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer research, 2005, Apr-01, Volume: 65, Issue:7 Topics: Antineoplastic Combined Chemotherapy Protocols; Caffeine; Camptothecin; Carboplatin; Carcinoma, Non-Small-Cell Lung; CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; Cellular Senescence; G2 Phase; Humans; Lung Neoplasms; Neoadjuvant Therapy; Paclitaxel; Randomized Controlled Trials as Topic; Research Support as Topic; RNA, Small Interfering; Transcription, Genetic; Tumor Suppressor Protein p53	2005
Cross-talk between DNA damage and cell survival checkpoints during G2 and mitosis: pharmacologic implications. Molecular cancer therapeutics, 2005, Volume: 4, Issue:12 Topics: Antineoplastic Agents, Alkylating; Blotting, Western; Caffeine; Cell Line; Cell Survival; DNA Damage; DNA Fragmentation; G2 Phase; Humans; Melphalan; Mitosis; Nocodazole; Paclitaxel; Signal Transduction	2005
Obtaining metaphase spreads from single blastomeres for PGD of chromosomal rearrangements. Reproductive biomedicine online, 2007, Volume: 14, Issue:4 Topics: Animals; Blastomeres; Caffeine; Chromosome Aberrations; Culture Media; Cytoplasm; Demecolcine; Embryo Culture Techniques; Humans; Marine Toxins; Metaphase; Mice; Oxazoles; Paclitaxel; Preimplantation Diagnosis; Zygote	2007
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell cycle (Georgetown, Tex.), 2009, Jul-15, Volume: 8, Issue:14 Topics: Antineoplastic Agents, Phytogenic; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Genomic Instability; Humans; Infrared Rays; Karyotyping; Paclitaxel; Phosphorylation; Protein Serine-Threonine Kinases; PTEN Phosphohydrolase; Rad51 Recombinase; RNA, Small Interfering; Telomere; Tumor Suppressor Proteins	2009
Caffeine inhibits paclitaxel‑induced apoptosis in colorectal cancer cells through the upregulation of Mcl‑1 levels. Molecular medicine reports, 2014, Volume: 9, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Butadienes; Caffeine; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Endoplasmic Reticulum Chaperone BiP; Extracellular Signal-Regulated MAP Kinases; Heat-Shock Proteins; Humans; Mitogen-Activated Protein Kinases; Myeloid Cell Leukemia Sequence 1 Protein; Nitriles; Paclitaxel; Signal Transduction; Up-Regulation	2014
Identifying enriched drug fragments as possible candidates for metabolic engineering. BMC medical genomics, 2016, 08-10, Volume: 9 Suppl 2 Topics: Antineoplastic Agents, Phytogenic; Biological Products; Caffeine; Databases, Pharmaceutical; Drug Discovery; Metabolic Engineering; Paclitaxel; Pharmaceutical Preparations; Styrene	2016
Modulation of chemotherapy-induced cytotoxicity in SH-SY5Y neuroblastoma cells by caffeine and chlorogenic acid. Toxicology mechanisms and methods, 2017, Volume: 27, Issue:5 Topics: Antineoplastic Agents; Apoptosis; Caffeine; Cell Line, Tumor; Cell Survival; Chlorogenic Acid; Deoxycytidine; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Gemcitabine; Humans; Paclitaxel; Reactive Oxygen Species	2017
Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 129 Topics: A549 Cells; Acetylation; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caffeine; Cell Movement; Cell Proliferation; Drug Interactions; Female; HeLa Cells; Humans; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Protein Processing, Post-Translational; Signal Transduction; Tubulin; Tumor Burden; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays	2020
Paclitaxel and Caffeine-Taurine, New Colchicine Alternatives for Chromosomes Doubling in Maize Haploid Breeding. International journal of molecular sciences, 2023, Sep-28, Volume: 24, Issue:19 Topics: Caffeine; Chromosomes, Plant; Colchicine; Haploidy; Humans; Paclitaxel; Plant Breeding; Zea mays	2023