pachypodol and 3-methylkaempferol

pachypodol has been researched along with 3-methylkaempferol* in 1 studies

Other Studies

1 other study(ies) available for pachypodol and 3-methylkaempferol

Article	Year
Antipoliovirus flavonoids from Psiadia dentata. Antiviral chemistry & chemotherapy, 2001, Volume: 12, Issue:5 The search for antiviral agents against vesicular stomatitis virus, herpes simplex virus type 1 and poliovirus type 2 in plants extracts, led to the isolation of two antipoliovirus flavonoids from the medicinal plant Psiadia dentata (Cass.) DC, Asteraceae: 3-methylkaempferol and 3,4'-dimethylkaempferol. The antipoliovirus activity of both compounds was estimated by comparison with 3-methylquercetin, guanidine and Ro-090179. The most potent inhibitor of poliovirus replication was 3-methylkaempferol, and therefore we investigated its mechanism of action. We showed, using the inhibition of [3H]uridine incorporation in viral RNA and performing a dot-blot with one RNA probe specific for the poliovirus genomic strand RNA, that 3-methylkaempferol inhibits the genomic RNA synthesis of poliovirus. Topics: Animals; Antiviral Agents; Asteraceae; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Flavonoids; Flavonols; Guanidine; Kaempferols; Molecular Structure; Plants, Medicinal; Poliovirus; Quercetin; RNA, Viral; Time Factors; Vero Cells; Virus Replication	2001

Article

Year

Antipoliovirus flavonoids from Psiadia dentata.

Antiviral chemistry & chemotherapy, 2001, Volume: 12, Issue:5

The search for antiviral agents against vesicular stomatitis virus, herpes simplex virus type 1 and poliovirus type 2 in plants extracts, led to the isolation of two antipoliovirus flavonoids from the medicinal plant Psiadia dentata (Cass.) DC, Asteraceae: 3-methylkaempferol and 3,4'-dimethylkaempferol. The antipoliovirus activity of both compounds was estimated by comparison with 3-methylquercetin, guanidine and Ro-090179. The most potent inhibitor of poliovirus replication was 3-methylkaempferol, and therefore we investigated its mechanism of action. We showed, using the inhibition of [3H]uridine incorporation in viral RNA and performing a dot-blot with one RNA probe specific for the poliovirus genomic strand RNA, that 3-methylkaempferol inhibits the genomic RNA synthesis of poliovirus.

Topics: Animals; Antiviral Agents; Asteraceae; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Flavonoids; Flavonols; Guanidine; Kaempferols; Molecular Structure; Plants, Medicinal; Poliovirus; Quercetin; RNA, Viral; Time Factors; Vero Cells; Virus Replication

2001