Page last updated: 2024-08-22

ozone and methacholine chloride

ozone has been researched along with methacholine chloride in 72 studies

Research

Studies (72)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (9.72)	18.7374
1990's	31 (43.06)	18.2507
2000's	22 (30.56)	29.6817
2010's	12 (16.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bethel, RA; Tan, WC	1
Fouke, JM; McFadden, ER; Wolin, AD	1
Aris, R; Balmes, JR; Christian, D; Sheppard, D	1
Haller, E; Rieder, P; van Melle, G; Zellweger, JP	1
Adachi, M; Kobayashi, H; Misawa, M; Okazawa, A; Takahashi, T	1
Fukuda, T; Ikeda, H; Nishikawa, M; Okubo, T; Suzuki, J; Suzuki, S	1
Eschenbacher, WL; Gross, KB; Terzo, TS; Ying, RL	1
Abdul-Salaam, S; Folinsbee, LJ; Horstman, DH; Ives, PJ; McDonnell, WF	1
Baltzer, P; Gamp, R; Keller, R; Keller-Wossidlo, H; Ragaz, A; Schaub, T	1
Anderson, K; Drazen, JM; Ingram, RH; Kariya, ST; Shore, SA; Skornik, WA	1
Bigby, BG; Boushey, HA; Goetzl, EJ; Holtzman, MJ; Leikauf, GD; Nadel, JA; Seltzer, J; Stulbarg, M; Ueki, IF	1
Delemos, RA; Fouke, JM; McFadden, ER	1
Johnson, HG; Ruppel, PL; Stout, BK	1
Chatham, MD; Eppler, JH; Green, D; Kulle, TJ; Sauder, LR	1
Adachi, M; Imai, T; Kamiya, I; Kobayashi, H; Nishikata, H; Okazawa, A; Satoh, H; Takahashi, T; Yamaguchi, H	1
Murlas, C; Roum, JH	1
Brain, JD; Jimba, M; Killingsworth, CR; Long, NC; Shore, SA; Skornik, WA	1
Fushimi, K; Ikezawa, K; Iwasaki, H; Kaminuma, O; Kikkawa, H; Matsubara, S; Shimazu, N	1
Aris, RM; Balmes, JR; Christian, D; Kelly, T; Tager, I	1
Gong, H; Linn, WS; Lyness, A; Weymer, AR	1
Bromberg, PA; Folinsbee, LJ; Hazucha, MJ; Seal, E	1
Abdul-Salaam, S; Folinsbee, LJ; Harder, S; Horstman, DH; Ives, PJ; Kehrl, HR	1
Emery, B; Hahn, B; Kaliner, MA; Ohkubo, K; Peden, DB; Swiersz, M	1
Bric, JM; Hyde, DM; Joad, JP; McDonald, RJ; Pino, MV	1
Gygax, H; Lustenberger, J; Van Melle, G; Zellweger, JP	1
Jörres, R; Magnussen, H; Nowak, D	1
Beckett, WS; Chen, AH; Pace, PE; Perlman, GD; Sferlazza, SJ; Xu, XP	1
Cox, C; Frampton, MW; Morrow, PE; Torres, A; Utell, MJ; Voter, KZ	1
Bast, A; Boere, AJ; Dormans, JA; Kramer, K; van Bree, L; van Hoof, HJ; Voss, HP	1
Leech, JA; Liu, L; Silverman, FS; Urch, RB	1
Aris, RM; Balmes, JR; Chen, LL; Christian, D; Ferrando, R; Finkbeiner, W; Hearne, PQ; Kelly, T; Scannell, C; Tager, IB; Welch, B	1
Cox, C; Frampton, MW; Morrow, PE; Speers, DM; Torres, A; Tsai, Y; Utell, MJ; Voter, KZ; Whitin, JC	1
Lopez-Aguilar, J; Manresa, F; Rodriguez, B; Romero, PV	1
Bonham, AC; Joad, JP; Kott, KS	1
Igarashi, A; Iijima, H; Shirato, K; Tamura, G	1
Corey, P; Hanania, NA; Senathirajah, N; Silverman, F; Tarlo, SM; Urch, B; Zamel, N	1
Bake, B; Hagberg, S; Henriksson, L; Ljungkvist, G; Olin, AC; Torén, K	1
Brahim, JJ; Hiemstra, PS; Hiltermann, JT; Lapperre, TS; Sont, JK; Steerenberg, PA; Sterk, PJ; Stolk, J; van Bree, L	1
Folinsbee, LJ; Hazucha, MJ	1
Cutler, D; Dey, RD; Dortch-Carnes, J; Fedan, JS; Frazer, DG; Goldsmith, WT; Hubbs, A; Johnston, RA; Millecchia, LL; Orsini, L; Rengasamy, A; Reynolds, JS; Watson, D; Yuan, LX	1
Fletcher, AM; Francis, HC; Higgins, BG; Pickering, CA; Warburton, CJ; Woodcock, AA; Yates, C	1
Brown, RH; Foster, WM; Macri, K; Mitchell, CS	1
Dey, RD; Fedan, JS; Frazer, DG; Maize, DF; Satterfield, BE; Wu, ZX	1
Doerschuk, CM; Le Blanc, B; Murthy, GG; Schwartzman, IN; Shore, SA	1
Hiltermann, JT; Peters, EA; Stolk, J	1
Chism, D; Johnston, RA; Krishna Murthy, GG; Schwartzman, IN; Shore, SA	1
Adachi, M; Ando, M; Fukuda, Y; Kuwaki, T; Ohmichi, M; Shima, M; Yamauchi, T	1
Bacci, E; Bartoli, ML; Carnevali, S; Cianchetti, S; Dente, FL; Di Franco, A; Giannini, D; Paggiaro, PL; Taccola, M; Vagaggini, B	1
Barraclough-Mitchell, H; Bassett, DJ; DeLorme, MP; Elbon-Copp, C; Gao, X; Yang, H	1
Johnston, RA; Rivera-Sanchez, YM; Schwartzman, IN; Shore, SA	1
Allen, CB; Balhorn, A; Dakhama, A; Dinarello, CA; Gelfand, EW; Joetham, A; Kim, SH; Kodama, T; Miyahara, N; Park, JW; Swasey, C; Takeda, K; Taube, C	1
Fredberg, JJ; Johnston, RA; Rivera-Sanchez, YM; Schwartzman, IN; Shore, SA; Silverman, ES; Valone, J	1
Foster, WM; Liao, G; Peltz, G; Savov, JD; Schwartz, DA; Usuka, J; Wang, J; Whitehead, GS	1
Johnston, RA; Mizgerd, JP; Shore, SA	1
Bric, JM; Gershwin, LJ; Joad, JP; Kott, KS; Peake, JL; Pinkerton, KE; Plopper, CG; Schelegle, ES	1
Lotriet, CJ; Oliver, DW; Venter, DP	1
Alexeeff, SE; Litonjua, AA; Schwartz, J; Sparrow, D; Suh, H; Vokonas, PS	1
Johnston, RA; Lu, FL; Shore, SA; Terry, RD; Theman, TA; Williams, ES	1
Shore, SA; Williams, ES; Zhu, M	1
Barker, JS; Batchelor, TP; Dey, RD; Wu, ZX	1
Andrews, D; Boykin, E; Farraj, AK; Gavett, SH; Ledbetter, A	1
Cooper, PR; Damera, G; FitzGerald, GA; Haczku, A; Hui, Y; Jester, WF; Jiang, M; Lawson, JA; Panettieri, RA; Tate, JC; Wang, M; Yao, Y; Zhao, H	1
Gelfand, EW; Larsen, ST; Matsubara, S; McConville, G; Poulsen, SS	1
Foster, WM; Que, LG; Stiles, JV; Sundy, JS	1
Feng, F; Foster, WM; Hollingsworth, JW; Li, Z; Potts-Kant, EN; Williams, KL; Wu, Y	1
Bacci, E; Bartoli, ML; Cianchetti, S; Costa, F; Dente, FL; Malagrinò, L; Novelli, F; Paggiaro, P; Vagaggini, B	1
Barreno, RX; Blackburn, MR; Cromar, KR; Hallberg, LM; Haque, IU; Hashmi, SS; Hernandez, CB; Johnston, RA; Nadas, AJ; Price, RE; Richards, JB; Schneider, DJ	1
Chen, L; Deng, Z; Gao, ZC; Ge, HQ; Pu, XP; Sun, SY; Wu, DY; Zhang, LR; Zhou, JJ; Zhu, ZP	1
Alcorn, JL; Alexander, AL; Atkins, CL; Bell, CS; Blackburn, MR; Cockerill, KJ; Cromar, KR; Haque, IU; Johnston, RA; Malik, F; Price, RE; Razvi, SS; Richards, JB; Spencer, CY; Weng, T	1
Fryer, AD; Jacoby, DB; Wicher, SA	1
Birukova, A; Cumming, RI; Cyphert-Daly, J; Gowdy, KM; Que, LG; Tighe, RM; Yu, YR	1
Cho, Y; Kasahara, DI; Osgood, RS; Shore, SA; Tashiro, H	1

Trials

13 trial(s) available for ozone and methacholine chloride

Article	Year
Indomethacin does not inhibit the ozone-induced increase in bronchial responsiveness in human subjects. The American review of respiratory disease, 1990, Volume: 142, Issue:4 Topics: Adolescent; Adult; Airway Resistance; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Forced Expiratory Volume; Humans; Indomethacin; Male; Methacholine Chloride; Ozone; Random Allocation; Vital Capacity	1990
Pre-exposure to ozone does not enhance or produce exercise-induced asthma. American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:6 Topics: Adult; Asthma, Exercise-Induced; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Exercise Test; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Ozone; Severity of Illness Index; Single-Blind Method; Time Factors; Vital Capacity	1994
Lung function response of healthy women after sequential exposures to NO2 and O3. American journal of respiratory and critical care medicine, 1994, Volume: 150, Issue:3 Topics: Adolescent; Adult; Air Pollutants; Airway Resistance; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Lung; Methacholine Chloride; Nitrogen Dioxide; Ozone; Plethysmography; Reference Values; Spirometry; Time Factors	1994
The effect of ozone exposure on allergen responsiveness in subjects with asthma or rhinitis. American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:1 Topics: Adult; Air; Allergens; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Ozone; Physical Exertion; Respiration; Rhinitis, Allergic, Perennial; Time Factors	1996
In vivo salicylate hydroxylation: a potential biomarker for assessing acute ozone exposure and effects in humans. American journal of respiratory and critical care medicine, 1997, Volume: 156, Issue:5 Topics: Adolescent; Adult; Airway Resistance; Aspirin; Biomarkers; Bronchial Provocation Tests; Bronchoconstrictor Agents; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Hydroxybenzoates; Hydroxylation; Inhalation Exposure; Methacholine Chloride; Ozone; Pulmonary Diffusing Capacity; Vital Capacity	1997
Effects of ozone on normal and potentially sensitive human subjects. Part II: Airway inflammation and responsiveness to ozone in nonsmokers and smokers. Research report (Health Effects Institute), 1997, Issue:78 Topics: Adolescent; Adult; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Data Interpretation, Statistical; Double-Blind Method; Female; Flow Cytometry; Forced Expiratory Volume; Humans; Inflammation; Interleukin-6; Interleukin-8; Lung; Macrophages, Alveolar; Male; Mast Cells; Methacholine Chloride; Ozone; Physical Exertion; Reactive Oxygen Species; Respiratory Mechanics; Smoking; Spirometry; Therapeutic Irrigation; Time Factors; Vital Capacity	1997
Effect of exposure to low levels of ozone on the response to inhaled allergen in allergic asthmatic patients. Chest, 1998, Volume: 114, Issue:3 Topics: Administration, Inhalation; Adolescent; Adult; Air Pollutants; Allergens; Asthma; Bronchial Provocation Tests; Cross-Over Studies; Female; Forced Expiratory Volume; Humans; Hypersensitivity; Male; Methacholine Chloride; Middle Aged; Ozone; Prospective Studies; Single-Blind Method; Skin Tests; Vital Capacity	1998
Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: a new noninvasive tool in epidemiologic studies on air pollution and asthma. Free radical biology & medicine, 1999, Volume: 27, Issue:11-12 Topics: Adult; Asthma; Biomarkers; Blood Proteins; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Inflammation; Interleukin-8; Leukocyte Count; Leukocyte Elastase; Male; Methacholine Chloride; Ozone; Placebos; Ribonucleases; Sputum	1999
Time course of response to ozone exposure in healthy adult females. Inhalation toxicology, 2000, Volume: 12, Issue:3 Topics: Administration, Inhalation; Adult; Air Pollutants; Airway Resistance; Atmosphere Exposure Chambers; Carbon Dioxide; Exercise Test; Female; Humans; Inhalation Exposure; Lung; Methacholine Chloride; Ozone; Plethysmography; Random Allocation; Respiratory Function Tests; Spirometry; Time Factors	2000
Bronchial reactivity of healthy subjects: 18-20 h postexposure to ozone. Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:5 Topics: Adult; Air Pollutants; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cross-Over Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Oxidants, Photochemical; Ozone; Spirometry; Temperature; Time Factors	2000
Effect of apocynin on ozone-induced airway hyperresponsiveness to methacholine in asthmatics. Free radical biology & medicine, 2001, Dec-01, Volume: 31, Issue:11 Topics: Acetophenones; Administration, Inhalation; Adult; Aerosols; Antioxidants; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; NADPH Oxidases; Ozone; Placebos	2001
Ozone exposure increases eosinophilic airway response induced by previous allergen challenge. American journal of respiratory and critical care medicine, 2002, Oct-15, Volume: 166, Issue:8 Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophils; Forced Expiratory Volume; Humans; Interleukin-8; Leukocyte Count; Methacholine Chloride; Oxidants, Photochemical; Ozone; Respiratory Mechanics; Single-Blind Method; Sputum; Vital Capacity	2002
Pulmonary function, bronchial reactivity, and epithelial permeability are response phenotypes to ozone and develop differentially in healthy humans. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 111, Issue:3 Topics: Adolescent; Adult; Black or African American; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cross-Over Studies; Female; Forced Expiratory Volume; Humans; Inhalation Exposure; Linear Models; Lung; Male; Methacholine Chloride; North Carolina; Ozone; Permeability; Phenotype; Radiopharmaceuticals; Respiratory Mucosa; Sex Factors; Technetium Tc 99m Pentetate; Time Factors; Vital Capacity; White People; Young Adult	2011

Other Studies

59 other study(ies) available for ozone and methacholine chloride

Article	Year
The effect of platelet activating factor antagonist on ozone-induced airway inflammation and bronchial hyperresponsiveness in guinea pigs. The American review of respiratory disease, 1992, Volume: 146, Issue:4 Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Eosinophils; Furans; Guinea Pigs; Male; Methacholine Chloride; Ozone; Platelet Activating Factor; Respiratory Function Tests	1992
Effects of ozone on lung mechanics and cyclooxygenase metabolites in dogs. Prostaglandins, 1991, Volume: 42, Issue:4 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Bronchoalveolar Lavage Fluid; Dinoprostone; Dogs; Humans; Lung; Methacholine Chloride; Ozone; Papio; Prostaglandins F; Respiratory Function Tests; Thromboxane B2	1991
The effects of sequential exposure to acidic fog and ozone on pulmonary function in exercising subjects. The American review of respiratory disease, 1991, Volume: 143, Issue:1 Topics: Adult; Air Pollutants; Airway Resistance; Bronchial Provocation Tests; Exercise; Female; Forced Expiratory Volume; Humans; Hydrogen-Ion Concentration; Male; Meteorological Concepts; Methacholine Chloride; Nitrates; Nitric Acid; Ozone; Respiration; Vital Capacity	1991
[Ozone, ventilatory function and bronchial reactivity]. Schweizerische medizinische Wochenschrift, 1991, Aug-17, Volume: 121, Issue:33 Topics: Adult; Air Pollutants; Bronchial Provocation Tests; Female; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Ozone; Respiratory Function Tests	1991
[The effect of leukotriene C4/D4 receptor antagonist (ONO-1078) and thromboxane A2 synthetase inhibitor (OKY-046) on airway hyperresponsiveness induced by ozone exposure in guinea pigs]. Nihon Kyobu Shikkan Gakkai zasshi, 1990, Volume: 28, Issue:2 Topics: Acrylates; Administration, Inhalation; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Chromones; Guinea Pigs; Methacholine Chloride; Methacholine Compounds; Methacrylates; Muscle Contraction; Ozone; Receptors, Immunologic; Receptors, Leukotriene; Thromboxane A2	1990
Dose-response relationship of ozone-induced airway hyperresponsiveness in unanesthetized guinea pigs. Journal of toxicology and environmental health, 1990, Volume: 30, Issue:2 Topics: Aerosols; Air Pollutants; Airway Resistance; Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; Methacholine Chloride; Methacholine Compounds; Ozone; Respiratory Physiological Phenomena; Respiratory System; Time Factors	1990
Ozone concentration and pulmonary response relationships for 6.6-hour exposures with five hours of moderate exercise to 0.08, 0.10, and 0.12 ppm. The American review of respiratory disease, 1990, Volume: 142, Issue:5 Topics: Adolescent; Adult; Airway Resistance; Bronchial Provocation Tests; Exercise; Forced Expiratory Volume; Humans; Male; Maximal Expiratory Flow Rate; Methacholine Chloride; Ozone; Respiratory Mechanics; Time Factors; Vital Capacity	1990
[Acute effects of the natural atmospheric ozone exposure on lung function of clinically normal smokers and non-smokers]. Schweizerische medizinische Wochenschrift, 1990, Nov-17, Volume: 120, Issue:46 Topics: Airway Obstruction; Bronchial Provocation Tests; Environmental Exposure; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Ozone; Smoking; Spirometry	1990
Methacholine-induced bronchoconstriction in dogs: effects of lung volume and O3 exposure. Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:6 Topics: Airway Resistance; Animals; Bronchi; Dogs; Dose-Response Relationship, Drug; Functional Residual Capacity; Lung Volume Measurements; Methacholine Chloride; Methacholine Compounds; Ozone	1988
O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 60, Issue:4 Topics: Adult; Airway Resistance; Arachidonic Acid; Arachidonic Acids; Bronchi; Cell Count; Female; Humans; Inflammation; Male; Methacholine Chloride; Methacholine Compounds; Neutrophils; Ozone; Respiratory Tract Diseases; Therapeutic Irrigation	1986
Airway response to ultra short-term exposure to ozone. The American review of respiratory disease, 1988, Volume: 137, Issue:2 Topics: Air Pollutants; Airway Resistance; Animals; Bronchial Provocation Tests; Cromolyn Sodium; Dose-Response Relationship, Drug; Drug Interactions; Lung; Male; Methacholine Chloride; Methacholine Compounds; Ozone; Papio; Time Factors	1988
Inhibition of the 5-lipoxygenase pathway with piriprost (U-60,257) protects normal primates from ozone-induced methacholine hyperresponsive small airways. Prostaglandins, 1988, Volume: 35, Issue:3 Topics: Airway Resistance; Animals; Arachidonate Lipoxygenases; Bronchi; Bronchial Diseases; Epoprostenol; Female; Lipoxygenase Inhibitors; Lung Compliance; Macaca mulatta; Methacholine Chloride; Methacholine Compounds; Ozone	1988
Evaluation of the effects of vitamin C on ozone-induced bronchoconstriction in normal subjects. Annals of the New York Academy of Sciences, 1987, Volume: 498 Topics: Adult; Ascorbic Acid; Bronchial Diseases; Constriction, Pathologic; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Ozone; Vitamin E	1987
[The effect of a specific antagonist of PAF (CV-3988) on airway hyperresponsiveness induced by ozone exposure in beagles]. Arerugi = [Allergy], 1987, Volume: 36, Issue:6 Topics: Animals; Bronchi; Dogs; Female; Methacholine Chloride; Methacholine Compounds; Ozone; Phospholipid Ethers; Platelet Activating Factor; Thiazoles; Thromboxane B2	1987
Ozone-induced changes in muscarinic bronchial reactivity by different testing methods. Journal of applied physiology: respiratory, environmental and exercise physiology, 1984, Volume: 57, Issue:6 Topics: Acetylcholine; Aerosols; Airway Resistance; Animals; Bronchi; Bronchial Provocation Tests; Bronchial Spasm; Dose-Response Relationship, Drug; Guinea Pigs; Infusions, Parenteral; Male; Methacholine Chloride; Methacholine Compounds; Muscarine; Ozone; Time Factors	1984
Role of C fibers in physiological responses to ozone in rats. Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 78, Issue:5 Topics: Aerosols; Animals; Animals, Newborn; Body Temperature; Capsaicin; Female; Heart Rate; Lung Compliance; Male; Methacholine Chloride; Nerve Fibers; Neurokinin A; Ozone; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Substance P	1995
Importance of impairment of the airway epithelium for ozone-induced airway hyperresponsiveness in guinea pigs. Japanese journal of pharmacology, 1995, Volume: 67, Issue:4 Topics: Administration, Inhalation; Analysis of Variance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Dose-Response Relationship, Drug; Eosinophils; Epithelium; Guinea Pigs; Inflammation; Injections, Intravenous; Lung; Macrophages; Male; Methacholine Chloride; Neutrophils; Ozone; T-Lymphocytes; Trachea	1995
Methacholine responsiveness is not associated with O3-induced decreases in FEV1. Chest, 1995, Volume: 107, Issue:3 Topics: Adult; Airway Resistance; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Ozone; Prospective Studies	1995
Respiratory responses to repeated prolonged exposure to 0.12 ppm ozone. American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:1 Topics: Analysis of Variance; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cough; Environmental Exposure; Exercise Test; Forced Expiratory Volume; Humans; Inflammation; Male; Methacholine Chloride; Ozone; Pain; Plethysmography, Whole Body; Time Factors; Vital Capacity	1994
Nasal secretion of the ozone scavenger uric acid. The American review of respiratory disease, 1993, Volume: 148, Issue:2 Topics: Albumins; Antioxidants; Humans; Lactoferrin; Methacholine Chloride; Muramidase; Nasal Mucosa; Nasal Provocation Tests; Ozone; Plasma; Probenecid; Turbinates; Uric Acid; Xanthine Oxidase	1993
Effects of ozone and neutrophils on function and morphology of the isolated rat lung. The American review of respiratory disease, 1993, Volume: 147, Issue:6 Pt 1 Topics: Animals; Bronchial Hyperreactivity; Humans; In Vitro Techniques; Lung; Methacholine Chloride; Neutrophils; Ozone; Perfusion; Rats; Rats, Sprague-Dawley; Time Factors	1993
[Ozone, respiratory function and bronchial reactivity. Study of a group of pre-Alpine agricultural workers]. Schweizerische medizinische Wochenschrift, 1993, May-22, Volume: 123, Issue:20 Topics: Adult; Aged; Agriculture; Altitude; Asthma; Bronchial Provocation Tests; Humans; Male; Methacholine Chloride; Middle Aged; Ozone; Respiratory Function Tests; Spirometry	1993
Airway reactivity in welders: a controlled prospective cohort study. Journal of occupational and environmental medicine, 1996, Volume: 38, Issue:12 Topics: Adult; Air Pollution; Analysis of Variance; Bronchial Hyperreactivity; Case-Control Studies; Cross-Over Studies; Female; Humans; Linear Models; Logistic Models; Male; Methacholine Chloride; Multivariate Analysis; Occupational Diseases; Ozone; Prospective Studies; Pulmonary Ventilation; Respiration Disorders; Smoking; Spirometry; Time Factors; United States; Welding	1996
Ozone responsiveness in smokers and nonsmokers. American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:1 Topics: Adolescent; Adult; Airway Resistance; Female; Forced Expiratory Volume; Humans; Logistic Models; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Oxidants, Photochemical; Ozone; Respiratory Mechanics; Smoking; Spirometry; Time Factors; Vital Capacity	1997
Changes in neuroreceptor function of tracheal smooth muscle following acute ozone exposure of guinea pigs. Toxicology, 1997, Jul-11, Volume: 120, Issue:3 Topics: Animals; Bronchial Hyperreactivity; Epithelium; Guinea Pigs; Isoproterenol; Male; Methacholine Chloride; Muscle, Smooth; Oxidants, Photochemical; Ozone; Receptors, Adrenergic, beta; Receptors, Muscarinic; Trachea	1997
Effects of ozone on normal and potentially sensitive human subjects. Part I: Airway inflammation and responsiveness to ozone in normal and asthmatic subjects. Research report (Health Effects Institute), 1997, Issue:78 Topics: Adolescent; Adult; Airway Resistance; Asthma; Biopsy; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoscopy; Data Interpretation, Statistical; Female; Forced Expiratory Volume; Humans; Immunohistochemistry; Inflammation; Interleukin-8; Lung; Male; Methacholine Chloride; Middle Aged; Ozone; Physical Exertion; Therapeutic Irrigation; Time Factors; Vital Capacity	1997
Parallel airways inhomogeneity and lung tissue mechanics in transition to constricted state in rabbits. Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 84, Issue:3 Topics: Airway Resistance; Animals; Biomechanical Phenomena; Forced Expiratory Flow Rates; Injections, Intravenous; Lung; Male; Methacholine Chloride; Muscarinic Agonists; Oxidants; Ozone; Pulmonary Alveoli; Rabbits; Respiratory Physiological Phenomena; Respiratory System; Trachea	1998
Exposing guinea pigs to ozone for 1 wk enhances responsiveness of rapidly adapting receptors. Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 84, Issue:4 Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Lung Compliance; Male; Mechanoreceptors; Methacholine Chloride; Muscarinic Agonists; Oxidants, Photochemical; Ozone; Respiratory Mechanics; Substance P	1998
Tazanolast inhibits ozone-induced airway hyperresponsiveness in guinea pigs. American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:5 Pt 1 Topics: Airway Resistance; Animals; Anti-Allergic Agents; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Dose-Response Relationship, Drug; Guinea Pigs; Male; Mast Cells; Methacholine Chloride; Neutrophils; Ozone; Tetrazoles	1998
Exhaled nitric oxide among pulpmill workers reporting gassing incidents involving ozone and chlorine dioxide. The European respiratory journal, 1999, Volume: 14, Issue:4 Topics: Adult; Air Pollutants, Occupational; Biomarkers; Bronchial Hyperreactivity; Chlorine Compounds; Female; Humans; Industry; Lung; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Occupational Diseases; Occupational Exposure; Oxides; Ozone; Paper; Respiration; Respiratory Function Tests	1999
Effect of ozone treatment on airway reactivity and epithelium-derived relaxing factor in guinea pigs. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:3 Topics: Animals; Dose-Response Relationship, Drug; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Methacholine Chloride; Nitric Oxide; Ozone; Perfusion; Trachea	2000
Environmental exposure to air pollution and allergens and peak flow changes. The European respiratory journal, 2000, Volume: 16, Issue:1 Topics: Adult; Aged; Air Pollutants; Allergens; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Nitrogen Dioxide; Ozone; Peak Expiratory Flow Rate; Pollen; Spores, Fungal	2000
Role of intrinsic airway neurons in ozone-induced airway hyperresponsiveness in ferret trachea. Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 91, Issue:1 Topics: Acetylcholine; Animals; Cholinergic Agonists; Culture Techniques; Electric Stimulation; Female; Ferrets; Methacholine Chloride; Muscarinic Agonists; Neurokinin-1 Receptor Antagonists; Neurons; Ozone; Piperidines; Substance P; Trachea; Tracheal Diseases	2001
Tumor necrosis factor receptor 2 contributes to ozone-induced airway hyperresponsiveness in mice. American journal of respiratory and critical care medicine, 2001, Aug-15, Volume: 164, Issue:4 Topics: Administration, Inhalation; Animals; Animals, Wild; Antigens, CD; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Environmental Exposure; Leukocyte Count; Methacholine Chloride; Mice; Mice, Knockout; Neutrophils; Oxidants, Photochemical; Ozone; Plethysmography, Whole Body; Pulmonary Ventilation; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Time Factors	2001
Ozone-induced airway hyperresponsiveness is reduced in immature mice. Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:3 Topics: Administration, Inhalation; Aging; Animals; Animals, Newborn; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Male; Methacholine Chloride; Mice; Mice, Inbred Strains; Oxidants, Photochemical; Ozone; Respiration	2002
Acute effects of ozone exposure on lung function in mice sensitized to ovalbumin. Toxicology, 2002, Mar-05, Volume: 172, Issue:1 Topics: Administration, Inhalation; Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Ovalbumin; Oxidants, Photochemical; Ozone; Respiratory Function Tests; Tumor Necrosis Factor-alpha	2002
Hyperresponsive airways correlate with lung tissue inflammatory cell changes in ozone-exposed rats. Journal of toxicology and environmental health. Part A, 2002, Oct-11, Volume: 65, Issue:19 Topics: Administration, Inhalation; Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Count; Collagenases; Inhalation Exposure; Lung; Male; Methacholine Chloride; Neutropenia; Neutrophils; Ozone; Rats; Rats, Wistar; Specific Pathogen-Free Organisms	2002
Responses to ozone are increased in obese mice. Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 95, Issue:3 Topics: Animals; Body Weight; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Cytokines; Female; Leptin; Male; Methacholine Chloride; Mice; Mice, Obese; Neutrophils; Obesity; Oxidants, Photochemical; Ozone; Phenotype; Respiratory Mechanics	2003
Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone. American journal of respiratory cell and molecular biology, 2004, Volume: 30, Issue:6 Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Dexamethasone; Female; Gene Expression Profiling; Gene Expression Regulation; Glucocorticoids; Humans; Interleukin-1; Methacholine Chloride; Mice; Mice, Inbred C57BL; Neutrophils; Oxidants, Photochemical; Ozone; Receptors, Interleukin-1; Respiratory Mucosa	2004
Differential effects of ozone on airway and tissue mechanics in obese mice. Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 96, Issue:6 Topics: Animals; Bronchial Hyperreactivity; Female; Lung; Male; Methacholine Chloride; Mice; Mice, Obese; Obesity; Ozone	2004
Ozone-induced acute pulmonary injury in inbred mouse strains. American journal of respiratory cell and molecular biology, 2004, Volume: 31, Issue:1 Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Cell Division; Chemotaxis, Leukocyte; Chromosome Mapping; Disease Models, Animal; Drug Resistance; Genetic Predisposition to Disease; Interleukin-6; Lung; Lung Diseases; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred Strains; Neutrophils; Ozone; Phenotype; Plethysmography; Respiratory Mucosa; Species Specificity	2004
CXCR2 is essential for maximal neutrophil recruitment and methacholine responsiveness after ozone exposure. American journal of physiology. Lung cellular and molecular physiology, 2005, Volume: 288, Issue:1 Topics: Animals; Bronchoconstrictor Agents; Chemokines; Lung; Lung Diseases; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophil Infiltration; Ozone; Receptors, Interleukin-8B; Respiratory System	2005
Structural and functional localization of airway effects from episodic exposure of infant monkeys to allergen and/or ozone. Toxicology and applied pharmacology, 2006, Aug-01, Volume: 214, Issue:3 Topics: Airway Resistance; Allergens; Animals; Animals, Newborn; Bronchi; Drug Synergism; Eosinophils; Inhalation Exposure; Leukocyte Count; Macaca mulatta; Methacholine Chloride; Neurosecretory Systems; Ozone; Pulmonary Alveoli; Pyroglyphidae; Respiratory Hypersensitivity	2006
The pharmacological effects of ozone on isolated guinea pig tracheal preparations. Archives of toxicology, 2007, Volume: 81, Issue:6 Topics: Animals; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; In Vitro Techniques; Isoproterenol; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Oxidants, Photochemical; Ozone; Trachea	2007
Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA normative aging study. Chest, 2007, Volume: 132, Issue:6 Topics: Aged; Aging; Bronchial Hyperreactivity; Bronchial Provocation Tests; Environmental Exposure; Forced Expiratory Volume; Humans; Likelihood Functions; Male; Methacholine Chloride; Obesity; Ozone; Regression Analysis; Spirometry; United States; Veterans; Vital Capacity	2007
Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation. Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:6 Topics: Airway Resistance; Animals; Body Weight; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation Mediators; Injections, Intravenous; Lung Compliance; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Obesity; Ozone; Phenotype; Pneumonia; Pulmonary Edema; Respiratory Mechanics	2008
No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice. Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:4 Topics: Administration, Oral; Animals; Asthma; Blood Glucose; Body Weight; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokines; Diabetes Mellitus; Disease Models, Animal; Female; Hypoglycemic Agents; Inflammation Mediators; Metformin; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Obese; Neutrophil Infiltration; Obesity; Ozone; Phenotype; Respiratory Mechanics	2008
Interleukin (IL)-1 regulates ozone-enhanced tracheal smooth muscle responsiveness by increasing substance P (SP) production in intrinsic airway neurons of ferret. Respiratory physiology & neurobiology, 2008, Dec-31, Volume: 164, Issue:3 Topics: Analysis of Variance; Animals; Antirheumatic Agents; Biophysics; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme-Linked Immunosorbent Assay; Female; Ganglia, Autonomic; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Methacholine Chloride; Muscarinic Agonists; Muscle, Smooth; Neurons; Organ Culture Techniques; Oxidants, Photochemical; Ozone; Substance P; Trachea	2008
Increased lung resistance after diesel particulate and ozone co-exposure not associated with enhanced lung inflammation in allergic mice. Inhalation toxicology, 2010, Volume: 22, Issue:1 Topics: Air Pollutants; Airway Resistance; Animals; Drug Synergism; Drug Therapy, Combination; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Oxidants, Photochemical; Ozone; Particulate Matter; Respiratory Hypersensitivity; Respiratory Mechanics; Vehicle Emissions	2010
Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:1 Topics: Airway Resistance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbachol; Cell Differentiation; Dinoprostone; Female; Gene Deletion; Intramolecular Oxidoreductases; Methacholine Chloride; Mice; Mice, Knockout; Microsomes; Muscle Contraction; Muscle, Smooth; Ozone; Prostaglandin-E Synthases; Prostaglandins; Respiratory System	2010
Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen. Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:11 Topics: Air Pollutants; Allergens; Animals; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Interactions; Inhalation Exposure; Leukocyte Count; Leukocytes; Lung; Methacholine Chloride; Mice; Mucus; Ovalbumin; Ozone; Periodic Acid-Schiff Reaction; Respiratory Function Tests	2010
Hyaluronan activation of the Nlrp3 inflammasome contributes to the development of airway hyperresponsiveness. Environmental health perspectives, 2012, Volume: 120, Issue:12 Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Carrier Proteins; Caspase 1; Hyaluronic Acid; Immunoblotting; Inflammasomes; Interleukin-1beta; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Ozone; Real-Time Polymerase Chain Reaction	2012
Baseline airway inflammation may be a determinant of the response to ozone exposure in asthmatic patients. Inhalation toxicology, 2013, Volume: 25, Issue:3 Topics: Adult; Asthma; Atmosphere Exposure Chambers; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Inflammation; Inhalation Exposure; Male; Methacholine Chloride; Neutrophils; Oxidants, Photochemical; Ozone; Sputum	2013
Endogenous osteopontin promotes ozone-induced neutrophil recruitment to the lungs and airway hyperresponsiveness to methacholine. American journal of physiology. Lung cellular and molecular physiology, 2013, Jul-15, Volume: 305, Issue:2 Topics: Animals; Asthma; Bronchoalveolar Lavage; Bronchoconstrictor Agents; Female; Lung; Lung Injury; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Mutant Strains; Neutrophil Infiltration; Neutrophils; Osteopontin; Oxidants, Photochemical; Ozone; Pneumonia	2013
Treatment responses of procaterol and CD38 inhibitors in an ozone-induced airway hyperresponsiveness mice model. Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:8 Topics: ADP-ribosyl Cyclase 1; Animals; Anti-Asthmatic Agents; Benzoates; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Indoles; Leukocyte Count; Lung; Male; Membrane Glycoproteins; Methacholine Chloride; Mice; NF-kappa B; Ozone; Procaterol	2013
Resistin deficiency in mice has no effect on pulmonary responses induced by acute ozone exposure. American journal of physiology. Lung cellular and molecular physiology, 2015, Nov-15, Volume: 309, Issue:10 Topics: Air Pollutants; Airway Resistance; Animals; Bronchoconstrictor Agents; Female; Lung; Male; Methacholine Chloride; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Ozone; Pneumonia; Resistin	2015
Newly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs. American journal of physiology. Lung cellular and molecular physiology, 2017, 06-01, Volume: 312, Issue:6 Topics: Animals; Bradycardia; Bromodeoxyuridine; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell Division; Electric Stimulation; Eosinophils; Etanercept; Female; Guinea Pigs; Immunization; Lymphocytes; Macrophages; Methacholine Chloride; Monocytes; Neutrophils; Ozone; Vagus Nerve	2017
Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses. Toxicological sciences : an official journal of the Society of Toxicology, 2019, 06-01, Volume: 169, Issue:2 Topics: Acute Disease; Animals; Cytokines; Female; Immunophenotyping; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ozone; Progesterone; Respiratory Hypersensitivity; Sex Characteristics	2019
Androgens augment pulmonary responses to ozone in mice. Physiological reports, 2019, Volume: 7, Issue:18 Topics: Androgen Antagonists; Androgens; Animals; Bronchoalveolar Lavage Fluid; Corticosterone; Cytokines; Flutamide; Interleukin-1alpha; Interleukin-6; Lung; Male; Methacholine Chloride; Mice, Inbred C57BL; Neutrophil Infiltration; Orchiectomy; Oxidative Stress; Ozone; Pneumonia; Respiratory Hypersensitivity; Respiratory Mechanics; Sex Characteristics	2019