ozagrel and vinpocetine

Brain ischemia leads to severe disruption of the nervous system and recovery is often prolonged. Rehabilitative post-ischemia pharmacological treatment may therefore be important for behavioral recovery, especially for cognition and motor behavior. The present study investigated the effects of combined vinpocetine and ozagrel administration on the behavioral recovery of rats from global brain ischemia. The results suggest that the combined treatment leads to significantly better improvement compared to single drug administration. We conclude that the combined use of vinpocetine and ozagrel may provide beneficial effects to patients suffering from brain ischemia.

Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cell Count; Male; Maze Learning; Methacrylates; Neurons; Neuroprotective Agents; Neuropsychological Tests; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome; Vinca Alkaloids