ozagrel and tetramethylpyrazine

ozagrel has been researched along with tetramethylpyrazine* in 1 studies

Other Studies

1 other study(ies) available for ozagrel and tetramethylpyrazine

Article	Year
Ligustrazine derivatives. Part 5: design, synthesis and biological evaluation of novel ligustrazinyloxy-cinnamic acid derivatives as potent cardiovascular agents. European journal of medicinal chemistry, 2011, Volume: 46, Issue:11 A series of novel ligustrazinyloxy-cinnamic acid derivatives were designed, synthesized and evaluated for their inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation in vitro, and also assayed for their protective effect against hydrogen peroxide (H(2)O(2))-induced oxidative damage on ECV-304 cells. Some compounds exhibited high activity in one or both of the assays, of which, compound 2e displayed the highest protective effect on the proliferation of the damaged ECV-304 cells (EC(50) = 0.020 mM), and compound 2f was the most active anti-platelet aggregation agent (EC(50) = 0.054 mM). Structure-activity relationships were briefly discussed. Topics: Animals; Cardiovascular Agents; Cell Line; Chemistry Techniques, Synthetic; Cinnamates; Cytoprotection; Drug Design; Endothelial Cells; Platelet Aggregation; Pyrazines; Rabbits; Structure-Activity Relationship	2011

Article

Year

Ligustrazine derivatives. Part 5: design, synthesis and biological evaluation of novel ligustrazinyloxy-cinnamic acid derivatives as potent cardiovascular agents.

European journal of medicinal chemistry, 2011, Volume: 46, Issue:11

A series of novel ligustrazinyloxy-cinnamic acid derivatives were designed, synthesized and evaluated for their inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation in vitro, and also assayed for their protective effect against hydrogen peroxide (H(2)O(2))-induced oxidative damage on ECV-304 cells. Some compounds exhibited high activity in one or both of the assays, of which, compound 2e displayed the highest protective effect on the proliferation of the damaged ECV-304 cells (EC(50) = 0.020 mM), and compound 2f was the most active anti-platelet aggregation agent (EC(50) = 0.054 mM). Structure-activity relationships were briefly discussed.

Topics: Animals; Cardiovascular Agents; Cell Line; Chemistry Techniques, Synthetic; Cinnamates; Cytoprotection; Drug Design; Endothelial Cells; Platelet Aggregation; Pyrazines; Rabbits; Structure-Activity Relationship

2011