oxytetracycline--anhydrous and meclocycline

Topics: Acne Vulgaris; Administration, Topical; Benzoyl Peroxide; Clindamycin; Dicarboxylic Acids; Erythromycin; Humans; Miconazole; Oxytetracycline; Salicylates; Salicylic Acid; Tretinoin

Eighty-one patients with clinical diagnosis of aerobic vaginitis (AV) were included in the study. The patients were randomized for treatment, 45 with kanamycin (100 mg vaginal ovules for 6 days, consecutively) and 36 with meclocycline (35 mg vaginal ovules for 6 days, consecutively). The patients were examined before starting the study, 1-2 days after treatment and 30 days after the end of the study. At the first follow-up the patients showed different levels of symptom reduction. Reduction in the presence of leukocytes, vaginal mucosa burning and itching were statistically significant in the group treated with kanamycin with respect to the group treated with meclocycline. Moreover, there was also reduced isolation of Enterobacteriaeae (97%) in the group treated with kanamycin versus those treated with meclocycline (76%). At the second follow-up, vaginal homeostasis (normalization of pH and presence of lactobacilli) was more evident in the kanamycin-treated group. In conclusion, our data suggest that the topical use of kanamycin could be considered a specific antibiotic for the therapy of this new pathology.

Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Bacteria, Aerobic; Female; Humans; Kanamycin; Lactobacillus; Oxytetracycline; Vaginitis

One hundred and six patients with acne vulgaris of the face were treated for 10 weeks with either topical meclocycline sulfosalicylate, topical benzoyl peroxide or both preparations. A randomized, double-blind parallel group study was used. Benzoyl peroxide proved more effective than meclocycline in reducing acne lesion counts, while local side effects were more common in the benzoyl peroxide-treated patients. The combined treatment was of intermediate efficacy with fewer local side effects.

Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Anti-Infective Agents, Local; Benzoyl Peroxide; Child; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Oxytetracycline

The clinical effect on acne vulgaris of topical treatment with meclocycline sulfosalicylate and systemic treatment with peroral tetracycline (500 mg daily) was compared in a double-blind study of 60 patients treated for 8 weeks. The reducing effect of Meclosorb cream and tetracycline tablets on the number of closed comedones, pustules, papules and cysts was marked and not significantly different. The effect of Meclosorb on open comedones was weak and of slow onset. No side effects were registered. Topical treatment with Meclosorb is an effective and safe alternative to systemic tetracycline treatment of acne vulgaris.

Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Oxytetracycline; Random Allocation; Tetracycline

Ten institutions participated in a controlled clinical trial in order to evaluate the efficacy of topical meclocycline and erythromycin in comparison to placebo with regard to papulopustular acne. Both drugs had been incorporated in the same galenic formulation that served as placebo. The vehicle employed in this study guaranteed equally favorable drug relies for both preparations. At the end of the trial, 419 patients could be evaluated for efficacy. As impartial criterion for evaluation, the number of inflammatory lesions on the right side of the face was counted before and after three months of treatment. In addition, we recorded the patients' and physicians' overall judgment at the end of the study. As compared with placebo, meclocycline as well as erythromycin brought about statistically significant improvement already after two months of treatment. After three months, the results were statistically very highly significant (p less than 0.001). At any time of the study, there could not be demonstrated any difference between the two groups treated with meclocycline and erythromycin.

Topics: Acne Vulgaris; Administration, Topical; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Double-Blind Method; Erythromycin; Humans; Oxytetracycline; Suppuration

A trial was performed in 30 patients affected by non-specific vaginitis. The results show that the topical application (by vaginal washings) of flunoxaprofen produces a high therapeutic activity like that of meclocycline. Contrary to meclocycline, flunoxaprofen does not possess bactericidal and bacteriostatic properties. Therefore, the normalization of vaginal flora, with a remarkable increase of Döderlein bacillus, is exclusively due to local antiphlogistic activity of flunoxaprofen. Contrary to meclocycline, flunoxaprofen induces a precocious increase of Döderlein bacillus, necessary for a definitive normalization and to limit the possibility of relapses.

Topics: Administration, Intravaginal; Adolescent; Adult; Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Female; Humans; Oxytetracycline; Vaginitis

Topics: Acne Vulgaris; Adult; Aged; Drug Evaluation; Drug Tolerance; Female; Humans; Male; Middle Aged; Oxytetracycline; Patch Tests; Photosensitivity Disorders

Topics: Adult; Drug Evaluation; Female; Humans; Oxytetracycline; Suppositories; Vaginitis

A rapid and sensitive high-performance liquid chromatographic quantitation of meclocycline (I) in a cream formulation is described. The acidified methanolic extract of the sample was diluted with mobile phase and analyzed on a reverse-phase column by using a mobile phase consisting of EDTA buffer (pH 6.6)-tetrahydrofuran (85:15 v/v). The method gave linear, quantitative, and reproducible results with a detection limit of 0.4 ppm for meclocycline.

Topics: Chromatography, Liquid; Ointments; Oxytetracycline

Topics: Child; Diarrhea; Drug Therapy; Dysentery; Humans; Oxytetracycline

Topics: Anti-Infective Agents, Local; Bacteria; Child; Diarrhea; Diarrhea, Infantile; Humans; Intestines; Mexico; Oxytetracycline; Pharmacology