oxypurinol has been researched along with tisopurine* in 2 studies
2 other study(ies) available for oxypurinol and tisopurine
Article | Year |
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Alternatives to allopurinol.
Topics: Allopurinol; Gout; Humans; Oxypurinol; Pyrimidines; Uricosuric Agents | 1987 |
[The effect of uricosuric and uricostatic drugs on DNA metabolism].
Some of the drugs, which are used in therapy of gout were tested with respect to their influence on semi-conservative DNA-synthesis and DNA-repair in vitro, using different cell systems. The agents (Benzbromarone, Allopurinol, Thiopurinol) were investigated in concentrations similar to blood-levels in normal therapy. The cells were irradiated with ultraviolet or ionizing radiation in order to damage their DNA and DNA-repair (unscheduled DNA-synthesis) was estimated by measuring the incorporation of radioactively labeled thymidine into acid insoluble material under appropriate conditions. The substances showed different effects on DNA-synthesis as well as on DNA-repair, even then, when their supposed influence on enzymes of nucleotide metabolism, was similar. Topics: Allopurinol; Benzbromarone; Cells, Cultured; DNA; Gout Suppressants; Oxypurinol; Radiation, Ionizing; Thymidine; Ultraviolet Rays; Uricosuric Agents | 1976 |