oxymatrine has been researched along with spironolactone in 1 studies
| Studies (oxymatrine) | Trials (oxymatrine) | Recent Studies (post-2010) (oxymatrine) | Studies (spironolactone) | Trials (spironolactone) | Recent Studies (post-2010) (spironolactone) |
|---|---|---|---|---|---|
| 412 | 16 | 270 | 7,222 | 960 | 1,923 |
| Protein | Taxonomy | oxymatrine (IC50) | spironolactone (IC50) |
|---|---|---|---|
| Chain A, Mineralocorticoid receptor | Homo sapiens (human) | 0.049 | |
| Chain A, Mineralocorticoid receptor | Homo sapiens (human) | 0.049 | |
| Estrogen receptor | Homo sapiens (human) | 5.702 | |
| Glucocorticoid receptor | Homo sapiens (human) | 4.0745 | |
| Progesterone receptor | Homo sapiens (human) | 1.675 | |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Mineralocorticoid receptor | Homo sapiens (human) | 0.0315 | |
| Androgen receptor | Homo sapiens (human) | 0.3585 | |
| Androgen receptor | Rattus norvegicus (Norway rat) | 0.406 | |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | 1.9025 | |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 6.92 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, CH; Shen, XC; Wang, YY; Xiao, TT; Zhang, Y | 1 |
1 other study(ies) available for oxymatrine and spironolactone
| Article | Year |
|---|---|
Similar to spironolactone, oxymatrine is protective in aldosterone-induced cardiomyocyte injury via inhibition of calpain and apoptosis-inducing factor signaling.
Topics: Aldosterone; Alkaloids; Animals; Animals, Newborn; Apoptosis; Apoptosis Inducing Factor; BH3 Interacting Domain Death Agonist Protein; Calpain; Caspase 3; Gene Expression Regulation; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Myocytes, Cardiac; Primary Cell Culture; Quinolizines; Rats; Rats, Sprague-Dawley; Signal Transduction; Spironolactone | 2014 |