Compounds > oxymatrine
Page last updated: 2024-09-02

oxymatrine and gamma-aminobutyric acid

oxymatrine has been researched along with gamma-aminobutyric acid in 5 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Compound Research Comparison

Studies
(oxymatrine)		Trials
(oxymatrine)		Recent Studies (post-2010)
(oxymatrine)		Studies
(gamma-aminobutyric acid)		Trials
(gamma-aminobutyric acid)		Recent Studies (post-2010) (gamma-aminobutyric acid)
4102740,2151,4239,631
4121627040,2151,4239,631

Protein Interaction Comparison

ProteinTaxonomyoxymatrine (IC50)gamma-aminobutyric acid (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.0292
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0332
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0323
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)2.152
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0333
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)5.2623
Sodium- and chloride-dependent taurine transporterHomo sapiens (human)354
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)2.51
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)6.349
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)7.0795
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)8.1283
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent betaine transporterHomo sapiens (human)6.4082
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)3.9953
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0333
GABA theta subunitRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.0292

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jiang, YX; Yu, JQ1
Gao, JX; Jiang, YX; Yan, L; Yang, G; Yi, ZH1
Gao, J; Jia, Y; Jiang, Y; Yan, L; Yang, G; Yu, J1
Dai, XY; Hao, YJ; Li, YX; Liu, HY; Sun, T; Wang, HY; Yu, JQ1
Deng, YO; Liu, YG; Lu, XQ; Wu, SX; Yang, L1

Other Studies

5 other study(ies) available for oxymatrine and gamma-aminobutyric acid

ArticleYear
[Effects of oxysophoridine on Glu and GABA immuno-reaction positive neurons in cortex and hippocampus of rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:19

    Topics: Alkaloids; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Immunohistochemistry; Male; Neurons; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley; Sophora

2006
[The influence of GABAA receptor on the analgesic action of intrathecally injected oxysophoridine].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2011, Volume: 46, Issue:5

    Topics: Alkaloids; Analgesics; Animals; Bicuculline; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Spinal; Male; Mice; Muscimol; Pain Threshold; Picrotoxin; Random Allocation; Receptors, GABA-A; Spinal Cord

2011
Oxysophoridine through intrathecal injection induces antinociception and increases the expression of the GABAAα1 receptor in the spinal cord of mice.
    Planta medica, 2012, Volume: 78, Issue:9

    Topics: Alkaloids; Analgesics; Animals; Bicuculline; Drug Evaluation, Preclinical; Drug Interactions; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Spinal; Mice; Mice, Inbred ICR; Muscimol; Pain Measurement; Picrotoxin; Receptors, GABA-A; Spinal Cord

2012
Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:12

    Topics: Alkaloids; Animals; Chronic Disease; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; GABA Plasma Membrane Transport Proteins; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Muscimol; Neuralgia; Neuroprotective Agents; Nipecotic Acids; Oximes; Pain Measurement; Pain Threshold; Quinolizines; Receptors, GABA-A; Spinal Cord

2012
[The Analgesia of Oxymatrine Affecting Calcium Channel and GABA Release].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2015, Volume: 35, Issue:5

    Topics: Alkaloids; Analgesia; Animals; Calcium; Calcium Channels; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Neuralgia; Pain Management; Quinolizines; Spinal Cord

2015