oxycodone has been researched along with naloxone in 213 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (2.35) | 18.7374 |
| 1990's | 5 (2.35) | 18.2507 |
| 2000's | 31 (14.55) | 29.6817 |
| 2010's | 145 (68.08) | 24.3611 |
| 2020's | 27 (12.68) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bánki, L; Deli, MA; Dvorácskó, S; Horváth, G; Kékesi, G; Keresztes, A; Macedonio, G; Mollica, A; Pieretti, S; Stefanucci, A; Tömböly, C; Tuboly, G; Walter, FR; Zádor, F | 1 |
| Culpepper-Morgan, JA; Foley, K; Houde, RW; Inturrisi, CE; Kreek, MJ; Marsh, F; Portenoy, RK | 1 |
| Foley, KM; Houde, RW; Inturrisi, CE; Moulin, DE; Nip, TJ; Reidenberg, B; Wallenstein, S; Weinberg, DS | 1 |
| Bagley, JR; Baker, JK; Riley, TN; Skelton, RE | 1 |
| Blazsó, G; Minker, E; Végh, A | 1 |
| Waite, E; Wang, RI | 1 |
| Bowers, CY; Chang, D; Chang, K; Hong, A; Momany, F; Reynolds, GA | 1 |
| Leow, KP; Smith, MT | 1 |
| Manfredi, B; Mantegazza, P; Panerai, AE; Sacerdote, P | 1 |
| Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G | 1 |
| Borsodi, A; Greiner, E; Hanoune, J; Monory, K; Pouille, Y; Sallai, L; Sartania, N; Schmidhammer, H | 1 |
| Porter, SJ; Somogyi, AA; White, JM | 1 |
| Barry, JD; Clark, RF; Ly, BT; Offerman, SR; Schneir, AB; Vadeboncoeur, TF; Williams, SR | 1 |
| Oster, P; Schuler, M | 1 |
| Cook, CD; Nickerson, MD | 1 |
| Calello, DP; Osterhoudt, KC; Shieh-Czaja, A | 1 |
| Kamei, J; Nozaki, C | 1 |
| Kalso, EA; Kontinen, VK; Lemberg, KK; Siiskonen, AO; Yli-Kauhaluoma, JT | 1 |
| Raffa, RB; Stone, DJ | 1 |
| Fleischer, W; Hopp, M; Leyendecker, P; Nadstawek, J; Reimer, K; Ruckes, C; Wirz, S | 1 |
| Fleischer, W; Grothe, B; Hermanns, K; Hopp, M; Leyendecker, P; Meissner, W; Reimer, K; Ruckes, C; Szombati, I; Vondrackova, D; Weber, S | 1 |
| Fleischer, W; Hopp, M; Leyendecker, P; Meissner, W; Mueller-Lissner, S; Nadstawek, J; Reimer, K; Ruckes, C; Wirz, S | 1 |
| Berkelhammer, DL; Brzeski, A; Coats, BD; Crysdale, NY; Hutchinson, MR; Johnson, KW; Judd, CM; Lewis, SS; Maier, SF; Northcutt, A; Skyba, DA; Vietz, CM; Watkins, LR | 1 |
| Bosse, B; Buschmann-Kramm, C; Holzer, P; Hopp, M; Leyendecker, P; Maier, C; Mikus, G; Reimer, K; Smith, K; Zenz, M | 1 |
| Bosse, B; De Andrés, J; Hopp, M; Krain, B; Kremers, W; Leyendecker, P; Löwenstein, O; Müller-Lissner, S; Nichols, T; Reimer, K; Simpson, K; Troy Ferrarons, J | 1 |
| Bailey, P; Grothe, B; Hopp, M; Leyendecker, P; Mundin, G; Reimer, K; Smith, K; Uhl, R | 1 |
| Bond, S; Hopp, M; Krain, B; Kremers, W; Leyendecker, P; Löwenstein, O; Nichols, T; Reimer, K; Rogers, PD; Schutter, U; Uhl, R | 1 |
| Meissner, W; Pogatzki-Zahn, EM; Sabatowski, R; Strumpf, M; Wiebalck, A; Wirz, S; Zahn, PK; Zirngibl, H | 1 |
| Jenkins, AJ; Juhascik, MP; Poirier, JG | 1 |
| Wilcock, A | 1 |
| Carter, LP; Haddox, JD; Henningfield, JE; Johnson, RE; Lindholm, A; McCormick, CG; Rosen, S; Seeger, V; Varughese, S; Waxman, D; Wissel, J | 1 |
| Leyendecker, P; Müller-Lissner, S; Rentz, AM; Yu, R | 1 |
| Black, R; Butler, SF; Chang, A; Folensbee, L; Grimes Serrano, JM; Katz, N | 1 |
| Clemens, KE; Mikus, G | 1 |
| Kapoor, S | 1 |
| Dürr, H; Hakl, M; Hopp, M; Hrib, R; Lejcko, J; Leyendecker, P; Meissner, W; Reimer, K; Sandner-Kiesling, A; Sevcik, P; Tarau, L; Uhl, R | 1 |
| Grunert, S; Meyer, C; Nolte, T; Schmidt, T; Schutter, U | 1 |
| Bohn, LM; Raehal, KM | 1 |
| Mueller-Lissner, S | 1 |
| Leppert, W | 2 |
| Blagden, M; Bosse, B; Hopp, M; Leyendecker, P; Löwenstein, O; Lux, EA; Reimer, K; Simpson, KH | 1 |
| Comer, SD; Jones, JD; Manubay, J; Sullivan, MA; Vosburg, SK | 1 |
| Bhalla, S; Gulati, A; Rapolaviciute, V | 1 |
| Bailey, P; Bond, S; Church, A; Connor, A; Hopp, M; Limb, M; Mundin, G; Palaniappan, K; Smith, K; Woodward, J | 1 |
| Clemens, KE; Klaschik, E; Quednau, I | 1 |
| Cleveland, JM; Roland, CL; Setnik, B; Webster, L | 1 |
| Adile, C; Ferrera, P; Mercadante, S | 1 |
| Bosse, B; Buschmann-Kramm, C; Müller-Lissner, S; Ueberall, MA | 1 |
| Fehlmann, P | 1 |
| Ahmedzai, SH; Bar-Sela, G; Bosse, B; Hopp, M; Leyendecker, P; Nauck, F | 1 |
| Suzuki, T | 1 |
| Compagnone, C; Ramelli, A; Tagliaferri, F | 1 |
| Hermanns, K; Junker, U; Nolte, T | 1 |
| Barton, G; Dunlop, W; Khan, I; Taylor, A; Uhl, R | 1 |
| Mercadante, S | 1 |
| Bailey, P; Bell, D; Bond, S; Hopp, M; Mundin, G; Smith, K; Woodward, J | 1 |
| Berling, I; Isbister, GK; Whyte, IM | 1 |
| Hahn, U; Heun, G; Krämer, M; Leuner, C; Mundin, GE; Mysicka, J; Smith, KJ | 1 |
| Huhtala, J; Karjalainen, P; Kokki, H; Kokki, M; Kuusniemi, K; Lemken, J; Oppermann, J; Sjövall, S; Zöllner, J | 1 |
| Giarratano, A; Mercadante, S | 1 |
| Casali, M; Gafforio, P; Gatti, A; Lazzari, M; Marcassa, C; Sabato, AF; Silvestri, C; Tufaro, G | 1 |
| Bjerkelund, CE; Comelon, M; Draegni, T; Lenz, H; Qvigstad, E; Raeder, J; Undersrud, H; Wisloeff-Aase, K | 1 |
| Bednarova, R; Miceli, L; Rizzardo, A; Rocca, GD; Sandri, M | 1 |
| Uddin, F | 1 |
| Bruera, E; Kang, JH; Lee, GW; Shin, SH | 1 |
| Cohen, J; Comer, SD; Cooper, ZD; Fugon, L; Jones, JD; Manubay, JM; Mogali, S; Roux, P; Sullivan, MA; Vosburg, SK | 1 |
| Allen, RP; Beneš, H; Bosse, B; García-Borreguero, D; Grote, L; Högl, B; Hopp, M; Kohnen, R; Oksche, A; Reimer, K; Trenkwalder, C; Winkelmann, J | 1 |
| Walters, AS | 1 |
| Connola, M; Cuomo, A; Esposito, G; Forte, CA; Marcassa, C; Russo, G | 1 |
| Caldarulo, C; Casali, M; Gafforio, P; Lazzari, M; Leonardis, F; Marcassa, C; Sabato, AF | 1 |
| Blome, CJ; Fischer, H; Goliasch, G; Koinig, H; Makarova, N; Nabecker, S; Rinoesl, H; Ruetzler, K; Sessler, DI | 1 |
| Burns, E; McWilliams, K; Ross, C | 1 |
| Burness, CB; Keating, GM | 1 |
| Coluzzi, F; Ruggeri, M | 3 |
| Bartlett, C; Colucci, SV; Harris, SC; Perrino, PJ; Shram, M; Wang, Y | 1 |
| Chiominto, MG; Di Giorgio, L; Rocco, A; Sodano, L; Touloupakis, G | 1 |
| Huygen, FJ; Koopmans-Klein, G; van Dongen, VC; van Megen, YJ; Van Zundert, J; Vanelderen, PJ | 1 |
| Astore, F; Ferrari, M; Grappiolo, G; Gurgone, A; Mazziotta, G; Scardino, M | 1 |
| de Biase, S; Gigli, GL; Lorenzut, S; Merlino, G; Valente, M | 1 |
| Gatta, L; Scarpignato, C | 1 |
| Ahmedzai, SH; Duerr, H; Hopp, M; Janecki, M; Leppert, W; Lomax, M; Pakosz, A | 1 |
| De Andrés, J; Koopmans, G; Lux, EA; Simpson, K; Van Megen, Y; Wagemans, M | 1 |
| Bednarova, R; Della Rocca, G; Marcassa, C; Miceli, L; Rizzardo, A | 1 |
| Müller, T | 1 |
| Blagden, M; Bosse, B; Duerr, H; Hafer, J; Hopp, M | 1 |
| Kern, KU; Krings, D; Waldmann-Rex, S | 1 |
| Clemens, KE; Dunlop, W; Morlion, B | 1 |
| Guerriero, F; Marcassa, C; Ricevuti, G; Rollone, M; Sgarlata, C | 1 |
| Dickerson, S; Junor, R; Kumar Bhutani, M; Thakur, D | 1 |
| Hermanns, K; Hesselbarth, S; Oepen, P | 1 |
| O'Brien, T | 1 |
| Kohan, LR; Tran, BW; Vorenkamp, KE | 1 |
| Dioh, A; Gorissen, M; Koopmans-Klein, G; Logé, D; Louis, F; Poelaert, J; van Megen, YJ; Van Op den Bosch, J | 1 |
| Mueller-Schwefe, GH; Ueberall, MA | 1 |
| Frohnhofen, H; Schlitzer, J | 1 |
| Ando, Y; Gyawali, B; Hayashi, N; Honda, K; Shimokata, T; Tsukuura, H | 1 |
| Baron, R; Blanco, FJ; Falke, D; Kennes, L; Likar, R; Martin-Mola, E; Müller, M; Steigerwald, I | 1 |
| Graudins, A; Greene, SL; Koutsogiannis, Z; Macleod, D; Robinson, J; Wong, A | 1 |
| Dauri, M; Madeo, G; Natoli, S; Pierantozzi, M; Pisani, A; Schirinzi, T; Stefani, A | 1 |
| Frampton, JE | 1 |
| Fanelli, A; Fanelli, G | 1 |
| Francis, M; Guerriero, F; Maurizi, N; Perna, S; Ricevuti, G; Rollone, M; Rondanelli, M; Sgarlata, C | 1 |
| Freye, R | 1 |
| Comella, C; Högl, B | 1 |
| Beardsley, PM; Walentiny, DM; Wiebelhaus, JM | 2 |
| Chaudhuri, KR; DeCesare, J; Ehret, R; Hopp, M; Krygowska-Wajs, A; Lomax, M; Marti, MJ; Martinez-Martin, P; Oksche, A; Rascol, O; Reimer, K; Sátori, M; Trenkwalder, C; Vališ, M | 1 |
| Antonini, A; Tinazzi, M | 1 |
| Goeree, J; Goeree, R | 1 |
| Baron, R; Binder, A; Falke, D; Jansen, JP; Kennes, L; Müller, M; Pombo-Suarez, M; Steigerwald, I | 1 |
| Caldarulo, C; Corli, O; Finocchi, S; Greco, MT; Lazzari, M; Marcassa, C | 1 |
| Kraus, S | 1 |
| Babalonis, S; Casselton, V; Lofwall, MR; Nuzzo, PA; Walsh, SL | 1 |
| Crotti, C; Ingegnoli, F; Ughi, N | 1 |
| Haigney, MC; Kao, D; Krantz, MJ; Mehler, PS; Sandhu, A | 1 |
| Hoback, J | 1 |
| Kathmann, W | 1 |
| Corli, O; Greco, MT; Guerriero, F; Roberto, A; Rollone, M; Sgarlata, C | 1 |
| Caldarulo, C; Carpenedo, R; Dauri, M; Lazzari, M; Marcassa, C; Natoli, S; Silvi, MB | 1 |
| de Biase, S; Gigli, GL; Merlino, G; Valente, M | 1 |
| Carlos, K; Carvalho, LB; Conti, C; de Oliveira, CO; de Oliveira, MM; Prado, GF; Prado, LB | 1 |
| Bosse, B; Hallström, Y; Hopp, M; Oertel, WH; Saletu-Zyhlarz, GM; Trenkwalder, C | 1 |
| Bass, A; Bramson, C; Geoffroy, P; Levy-Cooperman, N; Malhotra, B; Matschke, K; Setnik, B; Sommerville, KW; Wolfram, G | 1 |
| Boese, CK; Bredow, J; Dargel, J; Eysel, P; Lemken, J; Oppermann, J; Spies, CK; Unglaub, F; Zöllner, J | 1 |
| Billot, L; Day, RO; Koes, BW; Latimer, J; Lin, CW; Maher, CG; McLachlan, AJ | 1 |
| Balfour, A; Creamer, F; Fearon, KC; Foo, I; Nimmo, S; Norrie, JD; Paterson, HM; Williams, LJ | 1 |
| Boyle, F; Franklin, AE; Lovell, MR | 1 |
| Lexchin, J | 1 |
| Kokki, H; Kokki, M; Kuronen, M; Naaranlahti, T; Nyyssönen, T; Pikkarainen, I; Savolainen, S | 1 |
| Garbe, E; Jobski, K; Kollhorst, B; Schink, T | 1 |
| Cirone, S; Edwards, C; Folk, D; Gordon, J; Kahan, M; Kanate, D; Kelly, L; Kirlew, M; Main, F; Mamakwa, S; Parsons, P; Rea, S | 1 |
| Diaz, CJ; Goode, PA; Leonard, JB; Nair, V; Penoyar, JB | 1 |
| Amato, F; Ceniti, S; Consoletti, L; Magaldi, D; Mameli, S; Marcassa, C; Notaro, P; Palmieri, V; Pisanu, GM; Vellucci, R | 1 |
| Bosse, B; Dupoiron, D; Ellery, A; Hopp, M; Kremers, W; Loewenstein, O; Stachowiak, A | 2 |
| Abbott, NJ; Avdeef, A; Yusof, SR | 1 |
| Fox, LM; Hoffman, RS; Manini, AF; Vlahov, D | 1 |
| Ahrens, J; Haeseler, G; Karch, A; Liu, X; Prison, N; Schaefers, D | 1 |
| Bai, YJ; Huang, L; Jin, SH; Li, XJ; Liu, DH; Lv, SP; Ma, H; Wang, F; Wang, Y; Zhang, Y; Zhou, JG | 1 |
| Benevento, F; Bolondi, L; Brandi, G; De Lorenzo, S; Piscaglia, F; Samolsky Dekel, BG; Tovoli, F | 1 |
| Huygen, F; Koopmans-Klein, G; Mancini, I; Prenen, H; van Megen, Y; Van Op den Bosch, J | 1 |
| Ahn, JS; Eum, YJ; Hong, YS; Kang, JH; Kim, JE; Kim, JS; Kim, MK; Kim, SY; Kim, TW; Koh, SA; Lee, GW; Lee, KH; Yun, HJ | 1 |
| Coffin, BC; Dickerson, SL; Leppert, W; Morlion, BJ; Mueller-Lissner, SA; O'Brien, T; Vellucci, R | 1 |
| Brock, C; Drewes, AM; Gregersen, H; Grønlund, D; Krogh, K; Liao, D; Poulsen, JL | 1 |
| Lucas, CJ; Martin, JH; Patel, J | 1 |
| Kim, ES | 1 |
| Burkhard, FC; Curatolo, M; Furrer, MA; Kleeb, B; Löffel, LM; Schneider, MP; Wuethrich, PY | 1 |
| Baruffaldi, F; Carroll, FI; Comer, SD; Langston, TL; Laudenbach, M; Navarro, HA; Pentel, PR; Peterson, SJ; Pravetoni, M; Raleigh, MD; Runyon, SP; Winston, S | 1 |
| Jin, JY; Kang, JH; Kim, BS; Ko, YH; Kwon, JH; Park, HJ; Park, SY; Woo, IS | 1 |
| Bailo, C; Dalmasso, S; Fanelli, A; Manassero, A; Ugues, S | 1 |
| Castaño-Garcia, A; Varela, M | 1 |
| Camporesi, EM; Enten, G; Puri, S | 1 |
| Cavalloro, F; Ciuffreda, A; Ilardi, M; Marino, E; Piloni, D; Spiaggi, E; Stella, GM | 1 |
| Ahn, JS; Cho, KJ; Chung, SS; Hwang, CJ; Kim, DS; Kim, JH; Lee, JH; Lee, KY; Moon, SH; Park, HJ; Park, YS | 1 |
| Coma, J; De Sanctis, V; Estivill, P; Ferreras, J; Folch, J; Fuentes, J; Guitart, J; Jiménez, AJ; Moya, J; Rodelas, F; Salazar, R; Sanz, A; Tomás, A; Vargas, MI | 1 |
| Candy, B; Jones, L; Larkin, PJ; Stone, P; Vickerstaff, V | 2 |
| Amico, P; Dickenmann, M; Duthaler, U; Hammann, F; Haschke, M; Jehle, AW; Kalbermatter, S; Krähenbühl, S; Lenherr, C; Leuppi-Taegtmeyer, A; Liechti, ME; Meyer Zu Schwabedissen, HE; Schmid, Y | 1 |
| Pattullo, GG; Pattullo, V; Strasser, SI | 1 |
| Buckley, NA; Degenhardt, L; Karanges, EA; Larance, B; Pearson, SA; Schaffer, AL; Wilson, A | 1 |
| Leppert, W; Wordliczek, J; Zajaczkowska, R | 1 |
| Eng, G; Wakeman, SE; Walley, AY | 1 |
| Bettiol, A; Cricelli, C; Lapi, F; Lombardi, N; Magni, A; Marconi, E; Pecchioli, S; Vannacci, A | 1 |
| Lim, R; Moffat, AK; Pratt, NL; Ramsay, E; Roughead, EE | 1 |
| Ahlström, F; Backman, JT; Blomqvist, K; Bærentzen, S; Du, T; Hauglund, NL; Kalso, EA; Lilius, TO; Liu, G; Nedergaard, M; Rauhala, PV; Stæger, FF | 1 |
| Caffaro, MM; Fennell, TR; Mortensen, NP; Snyder, RW; Yueh, YL | 1 |
| Buhidma, Y; Duty, S; Leta, V; Malcangio, M; Ray Chaudhuri, K; Rukavina, K; Sportelli, C | 1 |
| Crossin, R; Lam, T; Lubman, D; Martin, C; Middleton, M; Nielsen, S; Scott, D; Smith, K; Wilson, J | 1 |
| Baruffaldi, F; Cheng, K; Fulenwider, HD; Hafeez, H; Manvich, DF; Nennig, SE; Pravetoni, M; Price, ME; Rice, KC; Schank, JR | 1 |
| Bruno, V; Farcy, N; Karnik, V; Zamorano, C | 1 |
| Calderini, E; Egan, CG; Iorno, V; Landi, L; Porro, GA | 1 |
| Chen, G; Hopp, M; Huang, M; Huang, Y; Leng, X; Lu, G; Lu, K; Weng, X; Yao, S; Zeng, X; Zhang, F | 1 |
| Aritomi, H; Asaki, T; Chiba, H; Fujita, M; Furue, Y; Kanemasa, T; Koike, K; Matsumoto, T; Matsuzaki, T; Muramoto, M; Nakamura, A; Shimada, S; Shimada, T; Takase, K; Watari, R; Yasufuku, K | 1 |
| Coma, E; González-Barboteo, J; Moreno, D; Olmo, M; Serrano, G | 1 |
| Abignano, G; Lettieri, G; Mennillo, GA | 1 |
| Daniels, B; Holliday, S; John, TN; Liauw, W; Lovell, M; Luckett, T; Pearson, SA; Phillips, J; Rowett, D; Tervonen, H | 1 |
| Cater, J; Hansen, E; Smith, T; Webster, LR | 1 |
| Chen, J; Duan, J; Hu, N; Yan, H; Yu, T; Zheng, S | 1 |
| Ciftcioglu, J; Eckstein, N; Haas, B; Jermar, S; Kaina, B; Weickhardt, S | 1 |
| Aggarwal, G; Ahmedzai, S; Douglas, C; Green, M; Le, BH; Nicoll, A | 1 |
| Beardsley, PM; Carper, M; Contreras, KM; Damaj, MI; Walentiny, DM | 1 |
| Caravaggio, S; Coluzzi, F; Rosiello, F; Ruggeri, M; Santori, C; Signorini, A | 1 |
| Hohmann, AG; Iyer, V; Pacheco, R; Woodward, TJ | 1 |
| DeFries, T; Leyde, S; Pratt, L; Suen, L | 1 |
| Hobbs, GA; Keitt, SA; Silva, F | 1 |
| Daunert, S; Deo, S; Dikici, E; Peyravian, N; Sun, E; Toborek, M | 1 |
| Barrachina, J; Inda, MD; López-Gil, S; López-Gil, V; Margarit, C; Morales, D; Muriel, J; Peiró, AM; Planelles, B; Vara-González, A | 1 |
| Del Balzo, G; Donadello, K; Gottin, L; Marinangeli, F; Martini, A; Nizzero, M; Polati, E; Rama, J; Schweiger, V; Secchettin, E; Varrassi, G; Vittori, A | 1 |
| Almeida, W; da Costa, NS; Galiciolli, MEA; Irioda, AC; Lima, LS; Margarete Cestari, M; Nogara, PA; Oliveira, CS; Pereira, ME | 1 |
| Berger, M; Hosseinzadeh, A; Krassioukov, A; Maharaj, A; Rizzardo, A; Sachdeva, R | 1 |
| Beardsley, PM; Elder, HJ; Walentiny, DM | 1 |
| Isbister, GK; Isoardi, KZ | 1 |
| Kitahara, H; Komatsu, S; Nakamura, S; Yamada, T; Yamamoto, T | 1 |
31 review(s) available for oxycodone and naloxone
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Meeting the challenges of opioid-induced constipation in chronic pain management - a novel approach.
Topics: Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Constipation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Laxatives; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Quality of Life | 2009 |
Combined oral prolonged-release oxycodone and naloxone in opioid-induced bowel dysfunction: review of efficacy and safety data in the treatment of patients experiencing chronic pain.
Topics: Administration, Oral; Chronic Disease; Clinical Trials as Topic; Constipation; Drug Administration Schedule; Drug Therapy, Combination; Humans; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Quality of Life; Receptors, Opioid; Safety | 2010 |
Fixed combination of oxycodone with naloxone: a new way to prevent and treat opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Drug Combinations; Humans; Laxatives; Morphine; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Treatment Outcome | 2010 |
The role of opioid receptor antagonists in the treatment of opioid-induced constipation: a review.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Delayed-Action Preparations; Drug Combinations; Humans; Laxatives; Naloxone; Naltrexone; Narcotic Antagonists; Oxycodone; Quaternary Ammonium Compounds | 2010 |
[Blood-brain barrier transport of opioid analgesics].
Topics: Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Humans; Mice; Morphine; Morphine Derivatives; Naloxone; Narcotic Antagonists; Organic Cation Transport Proteins; Oxycodone; Pentazocine; Rats | 2011 |
Combined oral prolonged-release oxycodone and naloxone in chronic pain management.
Topics: Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Humans; Naloxone; Oxycodone; Treatment Outcome | 2013 |
Oxycodone/naloxone in the management of patients with pain and opioid-induced bowel dysfunction.
Topics: Constipation; Drug Combinations; Gastrointestinal Tract; Humans; Naloxone; Oxycodone; Pain | 2014 |
Oxycodone/Naloxone prolonged-release: a review of its use in the management of chronic pain while counteracting opioid-induced constipation.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Drug Interactions; Humans; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Quality of Life | 2014 |
Clinical and economic evaluation of tapentadol extended release and oxycodone/naloxone extended release in comparison with controlled release oxycodone in musculoskeletal pain.
Topics: Chronic Pain; Cost-Benefit Analysis; Delayed-Action Preparations; Humans; Italy; Musculoskeletal Pain; Naloxone; Oxycodone; Phenols; Tapentadol; Treatment Outcome | 2014 |
ADMET considerations when prescribing novel therapeutics to treat restless legs syndrome.
Topics: Animals; Dopamine Agonists; Drug Combinations; Drug Design; Half-Life; Humans; Monoamine Oxidase Inhibitors; Naloxone; Oxycodone; Quality of Life; Restless Legs Syndrome; Severity of Illness Index | 2014 |
[Clinical and economical evaluation of new analgesics for the management of chronic pain].
Topics: Analgesics, Opioid; Chronic Pain; Cost-Benefit Analysis; Drug Combinations; Drug Costs; Economics, Pharmaceutical; Humans; Models, Economic; Naloxone; Oxycodone; Phenols; Quality of Life; Quality-Adjusted Life Years; Tapentadol | 2014 |
Quality of life and healthcare resource in patients receiving opioids for chronic pain: a review of the place of oxycodone/naloxone.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Gastrointestinal Diseases; Health Resources; Humans; Naloxone; Narcotic Antagonists; Oxycodone; Quality of Life; Randomized Controlled Trials as Topic | 2015 |
Impact of prolonged-release oxycodone/naloxone on outcomes affecting patients' daily functioning in comparison with extended-release tapentadol: a systematic review.
Topics: Chronic Pain; Constipation; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Headache; Humans; Naloxone; Nausea; Oxycodone; Phenols; Quality of Life; Tapentadol; Vomiting | 2015 |
[Sleep and sleep disorders in the elderly: Part 3: Restless legs syndrome].
Topics: Aged; Anemia, Iron-Deficiency; Cross-Sectional Studies; Dopamine Agonists; Drug Combinations; Female; Germany; Humans; Levodopa; Male; Naloxone; Oxycodone; Restless Legs Syndrome; Risk Factors; Sex Factors | 2015 |
Opioid-induced constipation.
Topics: Chloride Channel Agonists; Chronic Pain; Constipation; Humans; Laxatives; Lubiprostone; Naloxone; Oxycodone; Peptides; Phenols; Receptors, Opioid, mu; Tapentadol | 2015 |
Oxycodone/Naloxone PR: A Review in Severe Refractory Restless Legs Syndrome.
Topics: Central Nervous System Agents; Drug Combinations; Humans; Naloxone; Oxycodone; Restless Legs Syndrome | 2015 |
Developments in managing severe chronic pain: role of oxycodone-naloxone extended release.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Humans; Naloxone; Narcotic Antagonists; Oxycodone; Quality of Life; Severity of Illness Index | 2015 |
Therapeutic advances in restless legs syndrome (RLS).
Topics: Diet Therapy; Dopamine Agents; Drug Combinations; Humans; Iron; Naloxone; Oxycodone; Randomized Controlled Trials as Topic; Restless Legs Syndrome | 2015 |
Opioids in the treatment of restless legs syndrome: pharmacological and clinical aspects.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Dopamine Agents; Drug Combinations; Humans; Naloxone; Oxycodone; Quality of Life; Restless Legs Syndrome; Severity of Illness Index | 2016 |
Opioids for restless legs syndrome.
Topics: Analgesics, Opioid; Disorders of Excessive Somnolence; Humans; Naloxone; Oxycodone; Randomized Controlled Trials as Topic; Restless Legs Syndrome | 2016 |
Opioid-Induced Constipation Relief From Fixed-Ratio Combination Prolonged-Release Oxycodone/Naloxone Compared With Oxycodone and Morphine for Chronic Nonmalignant Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Drug Therapy, Combination; Humans; Morphine; Naloxone; Oxycodone; Randomized Controlled Trials as Topic | 2017 |
Oral Prolonged-Release Oxycodone/Naloxone for Managing Pain and Opioid-Induced Constipation: A Review of the Evidence.
Topics: Analgesics, Opioid; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Naloxone; Narcotic Antagonists; Oxycodone; Pain Management | 2018 |
Oxycodone/Naloxone Prolonged Release: A Review in Severe Chronic Pain.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Diarrhea; Drug Combinations; Gastrointestinal Tract; Humans; Naloxone; Nausea; Neoplasms; Oxycodone | 2017 |
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.
Topics: Constipation; Defecation; Female; Gastrointestinal Agents; Humans; Intestinal Diseases; Male; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Related Disorders; Oxycodone; Palliative Care; Piperidines; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Receptors, Opioid, mu | 2018 |
The role of oxycodone/naloxone in the management of patients with pain and opioid-induced constipation.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Gastrointestinal Diseases; Humans; Laxatives; Naloxone; Narcotic Antagonists; Oxycodone; Receptors, Opioid; Receptors, Opioid, mu; Tablets | 2019 |
Pain in Parkinson's disease: new concepts in pathogenesis and treatment.
Topics: Analgesics; Botulinum Toxins; Chronic Pain; Deep Brain Stimulation; Duloxetine Hydrochloride; Humans; Naloxone; Oxycodone; Pain Management; Parkinson Disease | 2019 |
Current Status of Pain Management in Parkinson's Disease.
Topics: Acetylcholine Release Inhibitors; Alanine; Analgesics; Antiparkinson Agents; Apomorphine; Benzylamines; Botulinum Toxins, Type A; Deep Brain Stimulation; Dopamine Agonists; Drug Combinations; Duloxetine Hydrochloride; Humans; Levodopa; Naloxone; Oxycodone; Pain; Pain Management; Pain Measurement; Pain Threshold; Parkinson Disease; Tetrahydronaphthalenes; Thiophenes | 2020 |
Oxycodone/naloxone prolonged-release tablets in patients with moderate-to-severe, chronic cancer pain: Challenges in the context of hepatic impairment.
Topics: Analgesics, Opioid; Cancer Pain; Constipation; Delayed-Action Preparations; Humans; Liver Diseases; Naloxone; Neoplasms; Oxycodone; Tablets | 2022 |
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.
Topics: Adult; Analgesics, Opioid; Child; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Induced Constipation; Oxycodone; Palliative Care; Quaternary Ammonium Compounds; Substance Withdrawal Syndrome | 2022 |
55 trial(s) available for oxycodone and naloxone
| Article | Year |
|---|---|
Crossover and parallel study of oral analgesics.
Topics: Administration, Oral; Adult; Aged; Analgesics; Analysis of Variance; Aspirin; Caffeine; Clinical Trials as Topic; Dextropropoxyphene; Drug Combinations; Humans; Middle Aged; Naloxone; Oxycodone; Phenacetin | 1981 |
Patient assessment of a novel therapeutic approach for the treatment of severe, chronic pain.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Chronic Disease; Constipation; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Patient Satisfaction; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2008 |
Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain.
Topics: Analgesics, Opioid; Chronic Disease; Constipation; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Low Back Pain; Male; Naloxone; Narcotic Antagonists; Oxycodone; Pain Measurement; Severity of Illness Index; Time Factors; Treatment Outcome | 2008 |
A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement | 2009 |
Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Europe; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Outpatients; Oxycodone; Pain; Primary Health Care | 2008 |
Single- and multiple-dose pharmacokinetic evaluation of oxycodone and naloxone in an opioid agonist/antagonist prolonged-release combination in healthy adult volunteers.
Topics: Administration, Oral; Adult; Anorexia; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Combinations; Female; Half-Life; Headache; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Nausea; Oxycodone; Receptors, Opioid; Tablets; Therapeutic Equivalency | 2008 |
Combined prolonged-release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe non-malignant chronic pain: a randomised controlled trial.
Topics: Analgesics, Opioid; Chronic Disease; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Treatment Outcome | 2009 |
Validation of the Bowel Function Index to detect clinically meaningful changes in opioid-induced constipation.
Topics: Analgesics, Opioid; Chronic Disease; Constipation; Delayed-Action Preparations; Diagnostic Self Evaluation; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Reproducibility of Results; Severity of Illness Index; Surveys and Questionnaires | 2009 |
Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain.
Topics: Aged; Analgesics, Opioid; Chronic Disease; Constipation; Defecation; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Treatment Outcome | 2010 |
Efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of moderate/severe chronic non-malignant pain: results of a prospectively designed pooled analysis of two randomised, double-blind clinical trials.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Constipation; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Patient Discharge; Safety; Treatment Outcome; Young Adult | 2010 |
The subjective, reinforcing, and analgesic effects of oxycodone in patients with chronic, non-malignant pain who are maintained on sublingual buprenorphine/naloxone.
Topics: Adult; Analgesia; Analgesics, Opioid; Buprenorphine; Double-Blind Method; Drug Synergism; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain, Intractable; Reinforcement Schedule | 2011 |
Naloxone as part of a prolonged release oxycodone/naloxone combination reduces oxycodone-induced slowing of gastrointestinal transit in healthy volunteers.
Topics: Adult; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Combinations; Gastrointestinal Transit; Humans; Male; Middle Aged; Naloxone; Oxycodone; Radionuclide Imaging | 2011 |
Bowel function during pain therapy with oxycodone/naloxone prolonged-release tablets in patients with advanced cancer.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Neoplasms; Oxycodone; Tablets | 2011 |
The abuse potential of Remoxy(®), an extended-release formulation of oxycodone, compared with immediate- and extended-release oxycodone.
Topics: Adolescent; Adult; Analgesics, Opioid; Chemistry, Pharmaceutical; Cross-Over Studies; Dosage Forms; Double-Blind Method; Fasting; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Placebos; Surveys and Questionnaires; Young Adult | 2011 |
A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naloxone; Neoplasms; Oxycodone; Quality of Life | 2012 |
Low absolute bioavailability of oral naloxone in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone | 2012 |
Validated in vitro/in vivo correlation of prolonged-release oxycodone/naloxone with differing dissolution rates in relation to gastrointestinal transit times.
Topics: Absorption; Area Under Curve; Chromatography, Liquid; Cross-Over Studies; Gastrointestinal Transit; Humans; Male; Naloxone; Oxycodone; Tablets; Tandem Mass Spectrometry | 2012 |
Prolonged-release oxycodone/naloxone in postoperative pain management: from a randomized clinical trial to usual clinical practice.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Constipation; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Oxycodone; Pain Management; Pain, Postoperative; Spine; Treatment Outcome; Young Adult | 2012 |
A comparison of oxycodone prolonged-release vs. oxycodone + naloxone prolonged-release after laparoscopic hysterectomy.
Topics: Adult; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hysterectomy; Laparoscopy; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain, Postoperative; Prospective Studies | 2013 |
Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised, placebo-controlled trial with an open-label extension.
Topics: Aged; Delayed-Action Preparations; Disorders of Excessive Somnolence; Dopamine Agonists; Double-Blind Method; Female; Flank Pain; Gastrointestinal Diseases; Humans; Male; Middle Aged; Naloxone; Oxycodone; Patient Selection; Quality of Life; Restless Legs Syndrome; Salvage Therapy; Severity of Illness Index; Sleep; Treatment Outcome | 2013 |
A randomised trial of oral versus intravenous opioids for treatment of pain after cardiac surgery.
Topics: Administration, Intravenous; Administration, Oral; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Cardiac Surgical Procedures; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naloxone; Narcotic Antagonists; Oxycodone; Pain, Postoperative | 2014 |
Abuse potential of intravenous oxycodone/naloxone solution in nondependent recreational drug users.
Topics: Adolescent; Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Humans; Injections, Intravenous; Male; Middle Aged; Naloxone; Opioid-Related Disorders; Oxycodone; Reward; Young Adult | 2014 |
Patient preference with respect to QoL and reduction in opioid-induced constipation (OIC) after treatment with prolonged-release (PR) oxycodone/naloxone compared with previous analgesic therapy [PREFER study].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Constipation; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Opioid-Related Disorders; Oxycodone; Patient Preference; Quality of Life | 2014 |
Long-term safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate-to-severe chronic cancer pain.
Topics: Aged; Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Follow-Up Studies; Humans; Male; Middle Aged; Naloxone; Neoplasms; Oxycodone; Pain Management; Pain Measurement; Quality of Life; Severity of Illness Index; Tablets; Treatment Outcome | 2015 |
Fixed ratio (2:1) prolonged-release oxycodone/naloxone combination improves bowel function in patients with moderate-to-severe pain and opioid-induced constipation refractory to at least two classes of laxatives.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Constipation; Defecation; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Laxatives; Male; Middle Aged; Naloxone; Neoplasms; Oxycodone; Treatment Outcome | 2014 |
Long-term evaluation of combined prolonged-release oxycodone and naloxone in patients with moderate-to-severe chronic pain: pooled analysis of extension phases of two Phase III trials.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Chronic Pain; Constipation; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Oxycodone; Surveys and Questionnaires | 2014 |
[Tapentadol prolonged release improves analgesia, functional impairment and quality of life in patients with chronic pain who have previously received oxycodone/naloxone].
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Back Pain; Chronic Pain; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Substitution; Female; Germany; Humans; Male; Middle Aged; Naloxone; Oxycodone; Pain Measurement; Patient Satisfaction; Phenols; Prospective Studies; Quality of Life; Tapentadol | 2014 |
[Neuropathic back pain origins verified or cannot be excluded. Comparative pain study: retard tapentadol versus an established fixed combination].
Topics: Back Pain; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Humans; Naloxone; Neuralgia; Oxycodone; Pain Measurement; Patient Satisfaction; Phenols; Prospective Studies; Tapentadol | 2014 |
Safety and efficacy of oxycodone/naloxone vs. oxycodone vs. morphine for the treatment of chronic low back pain: results of a 12 week prospective, randomized, open-label blinded endpoint streamlined study with prolonged-release preparations.
Topics: Adult; Aged; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Germany; Humans; Low Back Pain; Male; Middle Aged; Morphine; Naloxone; Oxycodone; Prospective Studies; Young Adult | 2015 |
Effectiveness of Tapentadol Prolonged Release (PR) Compared with Oxycodone/Naloxone PR for the Management of Severe Chronic Low Back Pain with a Neuropathic Component: A Randomized, Controlled, Open-Label, Phase 3b/4 Study.
Topics: Adult; Aged; Analgesics, Opioid; Delayed-Action Preparations; Endpoint Determination; Female; Humans; Low Back Pain; Male; Middle Aged; Naloxone; Narcotic Antagonists; Neuralgia; Oxycodone; Pain Measurement; Phenols; Tapentadol | 2016 |
Prolonged-release oxycodone-naloxone for treatment of severe pain in patients with Parkinson's disease (PANDA): a double-blind, randomised, placebo-controlled trial.
Topics: Aged; Analgesics, Opioid; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Oxycodone; Pain; Parkinson Disease; Treatment Outcome | 2015 |
Tolerability, Safety, and Quality of Life with Tapentadol Prolonged Release (PR) Compared with Oxycodone/Naloxone PR in Patients with Severe Chronic Low Back Pain with a Neuropathic Component: A Randomized, Controlled, Open-label, Phase 3b/4 Trial.
Topics: Adult; Aged; Analgesics, Opioid; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Endpoint Determination; Female; Health Status; Humans; Low Back Pain; Male; Middle Aged; Naloxone; Narcotic Antagonists; Neuralgia; Oxycodone; Pain Measurement; Phenols; Quality of Life; Tapentadol | 2016 |
Intranasal buprenorphine alone and in combination with naloxone: Abuse liability and reinforcing efficacy in physically dependent opioid abusers.
Topics: Administration, Intranasal; Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Oxycodone; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Young Adult | 2016 |
[Oxycodone/naloxone retard superior to tapentadol in the study].
Topics: Back Pain; Double-Blind Method; Drug Combinations; Naloxone; Neuralgia; Oxycodone; Pain Measurement; Phenols; Prospective Studies; Tapentadol | 2016 |
Sleep and Quality of Life Under Prolonged Release Oxycodone/Naloxone for Severe Restless Legs Syndrome: An Analysis of Secondary Efficacy Variables of a Double-Blind, Randomized, Placebo-Controlled Study with an Open-Label Extension.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Quality of Life; Restless Legs Syndrome; Sleep; Surveys and Questionnaires | 2016 |
Abuse Potential Study of ALO-02 (Extended-Release Oxycodone Surrounding Sequestered Naltrexone) Compared with Immediate-Release Oxycodone Administered Orally to Nondependent Recreational Opioid Users.
Topics: Administration, Oral; Analgesics, Opioid; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Illicit Drugs; Male; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone | 2017 |
Effect of prolonged-released oxycodone/naloxone in postoperative pain management after total knee replacement: a nonrandomized prospective trial.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Constipation; Delayed-Action Preparations; Female; Humans; Intestines; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain Measurement; Pain, Postoperative; Physical Therapy Modalities; Postoperative Complications; Prospective Studies | 2016 |
OPAL: a randomised, placebo-controlled trial of opioid analgesia for the reduction of pain severity in people with acute spinal pain. Trial protocol.
Topics: Acute Pain; Adolescent; Adult; Aged; Analgesics, Opioid; Australia; Cost-Benefit Analysis; Female; Humans; Low Back Pain; Male; Middle Aged; Naloxone; Neck Pain; Oxycodone; Pain Measurement; Research Design; Young Adult | 2016 |
Randomized open-label phase II study comparing oxycodone-naloxone with oxycodone in early return of gastrointestinal function after laparoscopic colorectal surgery.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Colectomy; Defecation; Delayed-Action Preparations; Drug Combinations; Drug Utilization; Eating; Feasibility Studies; Female; Flatulence; Humans; Laparoscopy; Male; Middle Aged; Naloxone; Oxycodone; Pain, Postoperative; Patient Compliance; Pilot Projects; Preanesthetic Medication; Time Factors | 2017 |
Opioid-Induced Bowel Dysfunction in Patients Undergoing Spine Surgery: Comparison of Oxycodone and Oxycodone-Naloxone Treatment.
Topics: Adult; Aged; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Neurosurgical Procedures; Outcome Assessment, Health Care; Oxycodone; Pain, Postoperative; Prospective Studies; Single-Blind Method; Surveys and Questionnaires | 2017 |
High dosage of a fixed combination oxycodone/naloxone prolonged release: efficacy and tolerability in patients with chronic cancer pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Breakthrough Pain; Cancer Pain; Chronic Pain; Constipation; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Laxatives; Male; Middle Aged; Naloxone; Neoplasms; Oxycodone; Pain Management; Pain Measurement; Quality of Life | 2017 |
Long-term efficacy and safety of oxycodone-naloxone prolonged-release formulation (up to 180/90 mg daily) - results of the open-label extension phase of a phase III multicenter, multiple-dose, randomized, controlled study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Oxycodone; Pain; Pain Management; Pain Measurement; Quality of Life; Treatment Outcome; Young Adult | 2017 |
A phase III randomized controlled study on the efficacy and improved bowel function of prolonged-release (PR) oxycodone-naloxone (up to 160/80 mg daily) vs oxycodone PR.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Oxycodone; Pain Management; Treatment Outcome; Young Adult | 2017 |
Combatting pain after orthopedic/trauma surgery- perioperative oral extended-release tapentadol vs. extended-release oxycodone/naloxone.
Topics: Analgesics, Opioid; Constipation; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Naloxone; Orthopedic Procedures; Oxycodone; Pain Measurement; Pain, Postoperative; Phenols; Postoperative Nausea and Vomiting; Prospective Studies; Single-Blind Method; Tapentadol | 2017 |
Prolonged release oxycodone and naloxone treatment counteracts opioid-induced constipation in patients with severe pain compared to previous analgesic treatment.
Topics: Aged; Analgesics, Opioid; Chronic Pain; Constipation; Defecation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Laxatives; Male; Middle Aged; Naloxone; Oxycodone; Prospective Studies; Quality of Life | 2017 |
Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial.
Topics: Adult; Cancer Pain; Female; Humans; Korea; Male; Naloxone; Oxycodone; Quality of Life; Young Adult | 2017 |
Prolonged-Release Oxycodone/Naloxone Improves Anal Sphincter Relaxation Compared to Oxycodone Plus Macrogol 3350.
Topics: Adolescent; Adult; Anal Canal; Analgesics, Opioid; Constipation; Cross-Over Studies; Defecation; Delayed-Action Preparations; Denmark; Double-Blind Method; Drug Combinations; Healthy Volunteers; Humans; Male; Muscle Relaxation; Naloxone; Narcotic Antagonists; Oxycodone; Polyethylene Glycols; Pressure; Surveys and Questionnaires; Time Factors; Young Adult | 2017 |
Can early oral prolonged-release oxycodone with or without naloxone reduce the duration of epidural analgesia after cystectomy? A 3-arm, randomized, double-blind, placebo-controlled trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Cystectomy; Double-Blind Method; Drug Delivery Systems; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain, Postoperative; Prospective Studies; Urinary Diversion | 2018 |
Efficacy and safety of oxycodone/naloxone as add-on therapy to gabapentin or pregabalin for the management of chemotherapy-induced peripheral neuropathy in Korea.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Antineoplastic Agents; Female; Gabapentin; Humans; Male; Middle Aged; Naloxone; Neuralgia; Oxycodone; Pain Management; Peripheral Nervous System Diseases; Pregabalin; Republic of Korea | 2018 |
Oral prolonged-release oxycodone/naloxone offers equivalent analgesia to intravenous morphine patient-controlled analgesia after total knee replacement. A randomized controlled trial.
Topics: Administration, Oral; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Delayed-Action Preparations; Drug Combinations; Female; Humans; Infusions, Intravenous; Male; Morphine; Naloxone; Oxycodone; Pain, Postoperative; Prospective Studies | 2018 |
Analgesic Efficacy and Safety of Prolonged-Release Oxycodone/Naloxone in Korean Patients with Chronic Pain from Spinal Disorders.
Topics: Aged; Analgesics, Opioid; Back Pain; Chronic Pain; Constipation; Delayed-Action Preparations; Dizziness; Drug Combinations; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Naloxone; Nausea; Oxycodone; Pain Measurement; Quality of Life; Republic of Korea; Severity of Illness Index; Spinal Diseases | 2018 |
Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions.
Topics: Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Female; Humans; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Morphinans; Naloxone; Narcotic Antagonists; Oxycodone; Oxymorphone; Prognosis; Renal Dialysis; Tissue Distribution | 2019 |
Long-term effect of oxycodone/naloxone on the management of postoperative pain after hysterectomy: a randomized prospective study.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Hysterectomy; Naloxone; Oxycodone; Pain, Postoperative; Prospective Studies | 2020 |
Prolonged-Release (PR) Oxycodone/Naloxone Improves Bowel Function Compared with Oxycodone PR and Provides Effective Analgesia in Chinese Patients with Non-malignant Pain: A Randomized, Double-Blind Trial.
Topics: Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; China; Chronic Pain; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Laxatives; Male; Middle Aged; Naloxone; Opioid-Induced Constipation; Oxycodone; Pain Management; Quality of Life | 2020 |
A Phase I Placebo-Controlled Trial Comparing the Effects of Buprenorphine Buccal Film and Oral Oxycodone Hydrochloride Administration on Respiratory Drive.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Buprenorphine; Double-Blind Method; Female; Humans; Male; Naloxone; Oxycodone | 2020 |
127 other study(ies) available for oxycodone and naloxone
| Article | Year |
|---|---|
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalins; Indoles; Mice; Molecular Structure; Naphthalenes; Oxycodone; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Structure-Activity Relationship | 2019 |
Treatment of opioid-induced constipation with oral naloxone: a pilot study.
Topics: Adult; Constipation; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Oxycodone; Pilot Projects; Substance-Related Disorders | 1992 |
Sublingual absorption of selected opioid analgesics.
Topics: Administration, Sublingual; Adult; Analgesics, Opioid; Analysis of Variance; Biological Availability; Buprenorphine; Fentanyl; Heroin; Humans; Hydromorphone; Levorphanol; Methadone; Morphine; Mouth; Naloxone; Oxycodone; Time Factors | 1988 |
Estimation of high pressure liquid chromatographic retention indices of narcotic analgetics and related drugs.
Topics: Analgesics, Opioid; Butanones; Chromatography, High Pressure Liquid; Fentanyl; Ketones; Naloxone; Octanols; Oxycodone; Oxymorphone; Water | 1980 |
Inhibition of ganglionic transmission by narcotic analgesics; an effect antagonized by naloxone, nalorphine and calcium.
Topics: Analgesics, Opioid; Animals; Calcium; Fentanyl; Ganglia, Sympathetic; Methadone; Morphine Derivatives; Nalorphine; Naloxone; Neural Inhibition; Oxycodone; Rana esculenta; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1981 |
Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro.
Topics: Amino Acid Sequence; Animals; Female; Growth Hormone; In Vitro Techniques; Naloxone; Oligopeptides; Oxycodone; Oxymorphone; Pituitary Gland; Rats; Structure-Activity Relationship | 1980 |
The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Morphinans; Morphine; Naloxone; Nociceptors; Oxycodone; Rats; Rats, Sprague-Dawley | 1994 |
Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study.
Topics: Animals; Cell Division; Codeine; Hydromorphone; Immune System; Immunosuppression Therapy; Interleukin-2; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Oxycodone; Structure-Activity Relationship | 1997 |
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1998 |
Opioid binding profiles of new hydrazone, oxime, carbazone and semicarbazone derivatives of 14-alkoxymorphinans.
Topics: Affinity Labels; Animals; Brain; In Vitro Techniques; Kinetics; Morphinans; Naloxone; Narcotic Antagonists; Oxycodone; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1999 |
Kinetics and inhibition of the formation of 6beta-naltrexol from naltrexone in human liver cytosol.
Topics: Adult; Aged; Analgesics, Opioid; Benzodiazepines; Chromatography, High Pressure Liquid; Corticosterone; Cytosol; Dihydrotestosterone; Enzyme Inhibitors; Humans; Kinetics; Liver; Microsomes, Liver; Middle Aged; Naloxone; Naltrexone; Oxidoreductases; Oxycodone; Reproducibility of Results; Substrate Specificity; Testosterone; Vitamin K | 2000 |
Massive OxyContin ingestion refractory to naloxone therapy.
Topics: Female; Humans; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Oxycodone; Respiration, Artificial; Severity of Illness Index; Suicide, Attempted; Treatment Outcome | 2002 |
[Increasing importance of opioids in geriatrics].
Topics: Aged; Analgesics, Opioid; Costs and Cost Analysis; Drug Prescriptions; Fentanyl; Geriatrics; Germany; Humans; Morphine; Naloxone; Oxycodone; Tramadol | 2005 |
Nociceptive sensitivity and opioid antinociception and antihyperalgesia in Freund's adjuvant-induced arthritic male and female rats.
Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Body Weight; Butorphanol; Dose-Response Relationship, Drug; Estrous Cycle; Female; Foot; Freund's Adjuvant; Hyperalgesia; Loperamide; Male; Morphine; Naloxone; Narcotic Antagonists; Nociceptors; Oxycodone; Pain Measurement; Pressure; Rats; Rats, Inbred Lew; Sex Characteristics | 2005 |
Sick sisters.
Topics: Analgesics, Opioid; Central Nervous System Diseases; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Miosis; Morphine; Naloxone; Oxycodone; Poisoning; Respiratory Insufficiency; Siblings; Treatment Outcome | 2005 |
[Quality of life suffers much in constipation. Plea for an intelligent pain therapy].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Constipation; Drug Combinations; Humans; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Quality of Life; Surveys and Questionnaires; Time Factors | 2006 |
Involvement of mu1-opioid receptor on oxycodone-induced antinociception in diabetic mice.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Oxycodone; Receptors, Opioid, mu; Streptozocin | 2007 |
[A milestone in pain therapy. Intelligent pain therapy with opioid-naloxone combination].
Topics: Chronic Disease; Clinical Trials as Topic; Constipation; Delayed-Action Preparations; Drug Combinations; Humans; Naloxone; Narcotics; Oxycodone; Pain | 2007 |
[New study demonstrates dual effect of an oxycodone/naloxone combination. Strong pain palliation and preserving intestinal function].
Topics: Analgesics, Opioid; Constipation; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Combinations; Gastrointestinal Motility; Humans; Naloxone; Oxycodone; Pain; Palliative Care; Randomized Controlled Trials as Topic; Sleep | 2007 |
[General practice study reveals simplification of therapy for physician and patients. Patient satisfaction and better quality of life].
Topics: Analgesics, Opioid; Constipation; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Combinations; Gastrointestinal Motility; Humans; Multicenter Studies as Topic; Naloxone; Oxycodone; Pain; Palliative Care; Patient Satisfaction; Quality of Life; Randomized Controlled Trials as Topic | 2007 |
Pharmacological characterization of noroxymorphone as a new opioid for spinal analgesia.
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Injections, Spinal; Male; Morphinans; Naloxone; Oxycodone; Pain Measurement; Rats; Rats, Sprague-Dawley | 2008 |
Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice.
Topics: Analgesics, Opioid; Animals; Codeine; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Hot Temperature; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Quinidine; Reserpine; Seizures; Stereoisomerism; Tramadol | 2008 |
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast).
Topics: Analgesia; Analgesics, Opioid; Animals; Anti-Bacterial Agents; Brain; Bronchodilator Agents; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Immunohistochemistry; Injections, Intraperitoneal; Male; Minocycline; Morphine; Naloxone; Opioid-Related Disorders; Oxycodone; Pain; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Weight Loss | 2009 |
[Use of controlled release opioids in perioperative pain therapy: a standpoint on a new warning advice in the literature on controlled release opioids].
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Drug Labeling; Gastric Emptying; Humans; Naloxone; Oxycodone; Pain, Postoperative; Patient Education as Topic; Patient Participation; Risk Assessment | 2009 |
Cross-reactivity of naloxone with oxycodone immunoassays: implications for individuals taking Suboxone.
Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cross Reactions; Drug Combinations; Humans; Immunoenzyme Techniques; Naloxone; Oxycodone; Patient Compliance | 2009 |
Prolonged-release naloxone can cause systemic opioid withdrawal.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Diarrhea; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Humans; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Patient Compliance; Practice Patterns, Physicians'; Substance Withdrawal Syndrome | 2009 |
Case histories in pharmaceutical risk management.
Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Dextroamphetamine; Drug and Narcotic Control; Drug Industry; History, 20th Century; History, 21st Century; Humans; Lisdexamfetamine Dimesylate; Methylphenidate; Naloxone; Oxycodone; Product Surveillance, Postmarketing; Risk Management; Sodium Oxybate; Substance-Related Disorders | 2009 |
[Modern pain therapy with dual advantage. Strong analgesia and superior tolerance].
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Combinations; Humans; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement | 2009 |
[Tolerated opioid therapy with oxycodone/naloxone. Better quality of life for osteoporosis patients].
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Combinations; Humans; Naloxone; Narcotic Antagonists; Osteoporosis; Oxycodone; Pain; Quality of Life | 2009 |
Estimating attractiveness for abuse of a not-yet-marketed "abuse-deterrent" prescription opioid formulation.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Chemistry, Pharmaceutical; Child; Counseling; Data Collection; Delayed-Action Preparations; Demography; Female; Humans; Injections; Male; Middle Aged; Models, Psychological; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Pentazocine; Prescription Drugs; Reproducibility of Results; Smoking; Young Adult | 2010 |
Emerging new therapeutic options for the management of opioid induced constipation.
Topics: Alprostadil; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Laxatives; Lubiprostone; Naloxone; Naltrexone; Narcotic Antagonists; Oxycodone; Quaternary Ammonium Compounds | 2010 |
Innovative pain therapy with a fixed combination of prolonged-release oxycodone/naloxone: a large observational study under conditions of daily practice.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Delayed-Action Preparations; Drug Therapy, Combination; Female; Germany; Humans; Intestines; Male; Middle Aged; Naloxone; Oxycodone; Pain; Prospective Studies; Quality of Life; Treatment Outcome | 2010 |
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Arrestins; beta-Arrestins; Drug Tolerance; Fentanyl; Hot Temperature; Male; Methadone; Mice; Mice, Knockout; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, mu | 2011 |
Determination of α(2)-adrenoceptor and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by agmatine and BMS182874.
Topics: Agmatine; Analgesics; Animals; Dansyl Compounds; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Naloxone; Oxycodone; Receptors, Adrenergic, alpha-2; Receptors, Endothelin; Yohimbine | 2011 |
Targinact--opioid pain relief without constipation?
Topics: Analgesics, Opioid; Constipation; Delayed-Action Preparations; Drug Combinations; Follow-Up Studies; Humans; Naloxone; Oxycodone; Pain; Randomized Controlled Trials as Topic | 2010 |
High doses of oxycodone-naloxone combination may provide poor analgesia.
Topics: Aged; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Combinations; Humans; Lung Neoplasms; Male; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Treatment Outcome | 2011 |
The Bowel Function Index for evaluating constipation in pain patients: definition of a reference range for a non-constipated population of pain patients.
Topics: Analgesics, Opioid; Chronic Disease; Constipation; Cross-Sectional Studies; Defecation; Female; Germany; Humans; Male; Middle Aged; Naloxone; Oxycodone; Pain; Quality of Life; Reference Values; Research Design; Surveys and Questionnaires | 2011 |
[A year of chronic pain with Targin--experience from daily practice. Interview with Dr. Patricia Fehlmann].
Topics: Administration, Oral; Analgesics, Opioid; Chronic Disease; Constipation; Drug Combinations; Evidence-Based Medicine; Humans; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Quality of Life; Switzerland; Treatment Outcome | 2011 |
[Opioids play a major role in multimodal pain therapy"].
Topics: Aged, 80 and over; Analgesics, Opioid; Combined Modality Therapy; Drug Combinations; Female; Guideline Adherence; Humans; Naloxone; Oxycodone; Pain; Pain Measurement | 2011 |
Some concerns about the article: "High doses of oxycodone-naloxone combination may provide poor analgesia.".
Topics: Analgesics, Opioid; Humans; Male; Naloxone; Oxycodone; Pain | 2012 |
Prolonged-release oxycodone/naloxone in the treatment of neuropathic pain - results from a large observational study.
Topics: Aged; Analgesics, Opioid; Chronic Pain; Constipation; Defecation; Delayed-Action Preparations; Drug Combinations; Female; Germany; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Neuralgia; Oxycodone; Pain Measurement; Prospective Studies; Quality of Life; Severity of Illness Index; Time Factors; Treatment Outcome | 2012 |
Quality of life benefits and cost impact of prolonged release oxycodone/naloxone versus prolonged release oxycodone in patients with moderate-to-severe non-malignant pain and opioid-induced constipation: a UK cost-utility analysis.
Topics: Analgesics, Opioid; Cohort Studies; Constipation; Cost-Benefit Analysis; Delayed-Action Preparations; Drug Combinations; Humans; Naloxone; Oxycodone; Pain; Quality of Life; Severity of Illness Index; United Kingdom | 2012 |
Clarifications on oxycodone-naloxone combination in cancer pain management.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Combinations; Humans; Naloxone; Narcotic Antagonists; Neoplasms; Oxycodone; Pain | 2012 |
Oxycodone overdose causes naloxone responsive coma and QT prolongation.
Topics: Adult; Analgesics, Opioid; Bradycardia; Coma; Drug Overdose; Electrocardiography; Female; Humans; Length of Stay; Long QT Syndrome; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Retrospective Studies | 2013 |
Prolonged-release oxycodone/naloxone in nonmalignant pain: single-center study in patients with constipation.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Oxycodone; Pain Measurement; Retrospective Studies; Treatment Outcome | 2013 |
Oxycodone + naloxone: choose morphine and optimal laxative therapy instead.
Topics: Analgesics, Opioid; Constipation; Drug Combinations; Humans; Laxatives; Morphine; Naloxone; Oxycodone | 2013 |
Use of opioids for pain relief while driving: when the patient meets the police.
Topics: Aged; Analgesics, Opioid; Automobile Driving; Humans; Low Back Pain; Male; Naloxone; Oxycodone; Tramadol | 2013 |
Hope in Fort Hope: First Nations community is winning the battle against prescription drug abuse.
Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Indians, North American; Male; Naloxone; Narcotic Antagonists; Ontario; Opiate Substitution Treatment; Opioid-Related Disorders; Oxycodone; Prescription Drug Misuse | 2013 |
Opioid withdrawal syndrome after treatment with low-dose extended-release oxycodone and naloxone in a gastric cancer patient with portal vein thrombosis.
Topics: Abdominal Pain; Analgesics, Opioid; Delayed-Action Preparations; Female; Humans; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Portal Vein; Stomach Neoplasms; Substance Withdrawal Syndrome; Treatment Outcome; Venous Thrombosis | 2013 |
Buprenorphine/naloxone as a promising therapeutic option for opioid abusing patients with chronic pain: reduction of pain, opioid withdrawal symptoms, and abuse liability of oral oxycodone.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Buprenorphine; Chronic Pain; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Oxycodone; Statistics, Nonparametric | 2013 |
Opioids and restless legs syndrome.
Topics: Female; Humans; Male; Naloxone; Oxycodone; Restless Legs Syndrome | 2013 |
Efficacy and gastrointestinal tolerability of oral oxycodone/naloxone combination for chronic pain in outpatients with cancer: an observational study.
Topics: Administration, Oral; Ambulatory Care; Analgesics, Opioid; Chronic Pain; Constipation; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Neoplasms; Oxycodone; Pain Management; Pain Measurement; Retrospective Studies; Treatment Outcome | 2014 |
Effectiveness and tolerability of low-dose oral oxycodone/naloxone added to anticonvulsant therapy for noncancer neuropathic pain: an observational analysis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Neuralgia; Oxycodone; Retrospective Studies | 2014 |
A cautionary tale of oral naloxone.
Topics: Aged; Analgesics, Opioid; Breast Neoplasms; Female; Humans; Liver Neoplasms; Naloxone; Narcotic Antagonists; Oxycodone; Pain | 2014 |
[The management of post-surgical pain in the patient treated for hallux valgus with percutaneous and minimally invasive technique].
Topics: Adult; Aged; Analgesics, Opioid; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Etoricoxib; Female; Hallux Valgus; Humans; Middle Aged; Minimally Invasive Surgical Procedures; Naloxone; Narcotic Antagonists; Orthopedic Procedures; Oxycodone; Pain Management; Pain, Postoperative; Prospective Studies; Pyridines; Sulfones | 2014 |
Single-shot epidural-spinal anesthesia followed by oral oxycodone/naloxone and ketoprofen combination in patients undergoing total hip replacement: analgesic efficacy and tolerability.
Topics: Aged; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Spinal; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Female; Humans; Ketoprofen; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Retrospective Studies | 2015 |
Comparing tapentadol to oxycodone/naloxone combination: building castles in the air.
Topics: Chronic Pain; Humans; Musculoskeletal Pain; Naloxone; Oxycodone; Phenols | 2015 |
Comparing tapentadol to oxycodone/naloxone combination: imagining castles in the air … while building sandcastles! Re: Coluzzi F, Ruggeri M. Clinical and economic evaluation of tapentadol extended release and oxycodone/naloxone extended release in compari
Topics: Chronic Pain; Humans; Musculoskeletal Pain; Naloxone; Oxycodone; Phenols | 2015 |
Alcohol, pain, and opioids: which is a major threat to driving ability?
Topics: Acoustic Stimulation; Adult; Aged; Alcohol Drinking; Analgesics, Opioid; Automobile Driving; Chronic Pain; Drug Combinations; Humans; Middle Aged; Naloxone; Oxycodone; Photic Stimulation; Psychomotor Performance; Reflex | 2014 |
[Large therapy studies. New options for restless legs syndrome therapy].
Topics: Controlled Clinical Trials as Topic; Delayed-Action Preparations; Dopamine Agents; Germany; Humans; Naloxone; Oxycodone; Restless Legs Syndrome | 2014 |
Efficacy and tolerability of low-dose oral prolonged-release oxycodone/naloxone for chronic nononcological pain in older patients.
Topics: Activities of Daily Living; Aged; Chronic Pain; Constipation; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Combinations; Drug Monitoring; Female; Humans; Italy; Male; Naloxone; Oxycodone; Pain Management; Pain Measurement; Prospective Studies; Quality of Life; Treatment Outcome | 2015 |
Prolonged-release oxycodone/naloxone in opioid-naïve patients - subgroup analysis of a prospective observational study.
Topics: Aged; Constipation; Defecation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Narcotics; Neoplasms; Oxycodone; Pain; Pain Management; Prospective Studies; Quality of Life | 2015 |
The attractiveness of opposites: agonists and antagonists.
Topics: Administration, Oral; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Drug Combinations; Humans; Naloxone; Narcotic Antagonists; Oxycodone; Pain | 2015 |
Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease.
Topics: Administration, Oral; Adult; Analgesics; Biotransformation; Chronic Pain; Female; Humans; Infusions, Intravenous; Joint Capsule Release; Kidney Failure, Chronic; Leg; Naloxone; Narcotic Antagonists; Oxycodone; Pain, Postoperative; Renal Dialysis; Respiratory Insufficiency; Treatment Outcome | 2015 |
Treatment with prolonged-release oxycodone/naloxone improves pain relief and opioid-induced constipation compared with prolonged-release oxycodone in patients with chronic severe pain and laxative-refractory constipation.
Topics: Aged; Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Laxatives; Male; Middle Aged; Naloxone; Oxycodone; Quality of Life | 2015 |
Oxycodone/naloxone preparation can cause acute withdrawal symptoms when misused parenterally or taken orally.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Child; Child, Preschool; Databases, Factual; Drug Combinations; Female; Humans; Incidence; Infant; Injections, Intravenous; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Poison Control Centers; Risk Factors; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Tablets; Victoria; Young Adult | 2015 |
Efficacy and safety profile of prolonged release oxycodone in combination with naloxone (OXN PR) in Parkinson's disease patients with chronic pain.
Topics: Aged; Aged, 80 and over; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Naloxone; Oxycodone; Parkinson Disease; Prospective Studies; Quality of Life; Treatment Outcome | 2015 |
Is oxycodone/naloxone effective and safe in managing chronic pain of a fragile elderly patient with multiple skin ulcers of the lower limbs? A case report.
Topics: Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Diabetes Complications; Drug Combinations; Female; Frail Elderly; Humans; Lower Extremity; Naloxone; Narcotic Antagonists; Oxycodone; Pain Management; Quality of Life; Skin Ulcer | 2015 |
[Effectiveness and tolerability of opioids for non-cancer pain].
Topics: Analgesics, Opioid; Drug Combinations; Humans; Naloxone; Narcotic Antagonists; Oxycodone; Pain | 2015 |
Effects of Acute and Repeated Administration of Oxycodone and Naloxone-Precipitated Withdrawal on Intracranial Self-Stimulation in Rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Electrodes, Implanted; Infusions, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Oxycodone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Stimulation; Substance Withdrawal Syndrome | 2016 |
Targeting pain in Parkinson's disease.
Topics: Analgesics, Opioid; Female; Humans; Male; Naloxone; Oxycodone; Pain; Parkinson Disease | 2015 |
Cost-effectiveness analysis of oxycodone with naloxone versus oxycodone alone for the management of moderate-to-severe pain in patients with opioid-induced constipation in Canada.
Topics: Adult; Analgesics, Opioid; Canada; Chronic Pain; Constipation; Cost-Benefit Analysis; Drug Combinations; Female; Humans; Male; Monte Carlo Method; Naloxone; Narcotic Antagonists; Oxycodone; Pain Management; Quality-Adjusted Life Years; Treatment Outcome | 2016 |
Efficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis.
Topics: Aged; Analgesics, Opioid; Chronic Pain; Constipation; Defecation; Drug Combinations; Female; Humans; Laxatives; Male; Middle Aged; Naloxone; Narcotic Antagonists; Neoplasms; Oxycodone; Pain Measurement; Propensity Score; Quality of Life; Retrospective Studies; Rome; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2015 |
[Dual effect prevents chronic course].
Topics: Chronic Pain; Delayed-Action Preparations; Drug Combinations; Humans; Naloxone; Oxycodone; Phenols; Tapentadol | 2015 |
Effectiveness and safety of oxycodone/naloxone in the management of chronic pain in patients with systemic sclerosis with recurrent digital ulcers: two case reports.
Topics: Administration, Oral; Aged; Analgesics, Opioid; Chronic Pain; Drug Therapy, Combination; Female; Fingers; Humans; Middle Aged; Naloxone; Oxycodone; Pain Management; Quality of Life; Scleroderma, Systemic; Skin Ulcer; Wound Healing | 2016 |
Cardiovascular disorders associated with naloxone monotherapy and in fixed-dose combination with opioids: Data from international safety surveillance.
Topics: Cardiovascular Diseases; Drug Combinations; Humans; Naloxone; Oxycodone; Pharmacovigilance; Tilidine; World Health Organization | 2016 |
OVERDOSED ON OPIOIDS: A deadly opioid epidemic sweeping the country has lawmakers working hard to find solutions.
Topics: Analgesics, Opioid; Drug Overdose; Heroin; Humans; Legislation, Drug; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Prescription Drugs; United States | 2016 |
Targinact for restless legs syndrome.
Topics: Analgesics, Opioid; Dopamine Agonists; Drug Combinations; Humans; Naloxone; Oxycodone; Practice Guidelines as Topic; Restless Legs Syndrome | 2016 |
Long-term efficacy and safety of oxycodone-naloxone prolonged release in geriatric patients with moderate-to-severe chronic noncancer pain: a 52-week open-label extension phase study.
Topics: Aged; Aged, 80 and over; Analgesics; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Naloxone; Oxycodone; Prospective Studies; Safety; Time Factors | 2016 |
Switching to low-dose oral prolonged-release oxycodone/naloxone from WHO-Step I drugs in elderly patients with chronic pain at high risk of early opioid discontinuation.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Italy; Male; Naloxone; Oxycodone; Pain Measurement; Quality of Life; Retrospective Studies; Severity of Illness Index | 2016 |
A Case of Opioid Toxicity on Conversion From Extended-Release Oxycodone and Naloxone to Extended-Release Oxycodone in a Patient With Liver Dysfunction.
Topics: Aged; Analgesics, Opioid; Cancer Pain; Carcinoma, Ductal; Delayed-Action Preparations; Drug Combinations; Drug Substitution; Female; Humans; Liver Diseases; Naloxone; Oxycodone | 2017 |
Hippocrates and Targin.
Topics: Advertising; Analgesics, Opioid; Drug Combinations; Drug Industry; Humans; Naloxone; Opioid-Related Disorders; Oxycodone; Periodicals as Topic | 2016 |
The Risk of Ischemic Cardio- and Cerebrovascular Events Associated with Oxycodone-Naloxone and Other Extended-Release High-Potency Opioids: A Nested Case-Control Study.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Case-Control Studies; Cerebrovascular Disorders; Delayed-Action Preparations; Female; Germany; Humans; Male; Middle Aged; Myocardial Ischemia; Naloxone; Oxycodone; Retrospective Studies; Risk | 2017 |
Evaluation of 6 remote First Nations community-based buprenorphine programs in northwestern Ontario: Retrospective study.
Topics: Adult; Benzodiazepines; Buprenorphine; Cocaine; Community Health Services; Counseling; Drug Therapy, Combination; Female; Humans; Indians, North American; Male; Medication Adherence; Middle Aged; Morphine; Naloxone; Narcotic Antagonists; Ontario; Opiate Substitution Treatment; Opioid-Related Disorders; Oxycodone; Program Evaluation; Retrospective Studies; Rural Health Services; Substance Abuse Detection; Suicide; Young Adult | 2017 |
Potential drug interaction with opioid agonist in the setting of chronic low-dose opioid antagonist use.
Topics: Aged; Analgesics, Opioid; Disabled Persons; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Multiple Sclerosis; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Pressure Ulcer; Treatment Outcome | 2017 |
Impact of capillary flow hydrodynamics on carrier-mediated transport of opioid derivatives at the blood-brain barrier, based on pH-dependent Michaelis-Menten and Crone-Renkin analyses.
Topics: Analgesics, Opioid; Animals; Biological Transport; Blood-Brain Barrier; Hydrogen-Ion Concentration; Kinetics; Models, Biological; Naloxone; Oxycodone; Pentazocine; Permeability; Rats | 2017 |
Risk factors for severe respiratory depression from prescription opioid overdose.
Topics: Adult; Age Factors; Analgesics, Opioid; Cohort Studies; Drug Overdose; Emergency Service, Hospital; Female; Fentanyl; Humans; Intubation, Intratracheal; Male; Methadone; Middle Aged; Multivariate Analysis; Naloxone; Narcotic Antagonists; Odds Ratio; Oxycodone; Prescription Drug Misuse; Prospective Studies; Respiration, Artificial; Respiratory Insufficiency; Risk Factors; Severity of Illness Index; United States | 2018 |
Oral oxycodone/naloxone for pain control in cirrhosis: Observational study in patients with symptomatic metastatic hepatocellular carcinoma.
Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Carcinoma, Hepatocellular; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Female; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Preliminary Data; Quality of Life; Treatment Outcome | 2018 |
Comment on a paper by Dupoiron et al. "A phase III randomized controlled study on the efficacy and improved bowel function of prolonged-release (PR) oxycodone- naloxone (up to 160/80 mg daily) versus oxycodone PR".
Topics: Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Naloxone; Narcotic Antagonists; Oxycodone | 2017 |
Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse.
Topics: Animals; Antidotes; Male; Mice; Naloxone; Opioid-Related Disorders; Oxycodone; Rats; Vaccines | 2017 |
Oral oxycodone/naloxone for pain control in cirrhosis: Start slow, go slow.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Combinations; Humans; Liver Cirrhosis; Naloxone; Oxycodone; Pain | 2018 |
Postoperative analgesia choices in total knee replacement.
Topics: Analgesia, Patient-Controlled; Arthroplasty, Replacement, Knee; Humans; Morphine; Naloxone; Oxycodone | 2018 |
Prolonged-release oxycodone-naloxone for pain management in advanced EGFR wild-type lung cancer patients.
Topics: Aged; Cancer Pain; Delayed-Action Preparations; Drug Combinations; ErbB Receptors; Female; Humans; Lung Neoplasms; Male; Naloxone; Oxycodone; Pain Management; Retrospective Studies | 2018 |
Efficacy and Safety of Sublingual Fentanyl Tablets in Breakthrough Cancer Pain Management According to Cancer Stage and Background Opioid Medication.
Topics: Administration, Sublingual; Aged; Analgesics, Opioid; Breakthrough Pain; Drug Combinations; Drug Therapy, Combination; Female; Fentanyl; Humans; Male; Naloxone; Neoplasm Staging; Neoplasms; Oxycodone; Pain Management; Quality of Life; Treatment Outcome | 2018 |
Nociceptin/orphanin FQ receptors modulate the discriminative stimulus effects of oxycodone in C57BL/6 mice.
Topics: Analgesics, Opioid; Animals; Benzimidazoles; Imidazoles; Ligands; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Nociceptin Receptor; Opioid-Related Disorders; Oxycodone; Piperidines; Receptors, Opioid; Spiro Compounds | 2018 |
Adverse effects of modified release oxycodone/naloxone in patients with moderate to severe liver impairment.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Humans; Liver; Liver Diseases; Naloxone; Oxycodone | 2018 |
Increases in controlled-release oxycodone utilisation following the subsidy of oxycodone with naloxone formulations: An Australian population-based study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Australia; Chronic Pain; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Combinations; Drug Utilization; Female; Humans; Interrupted Time Series Analysis; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Practice Patterns, Physicians'; Retrospective Studies; Severity of Illness Index; Substance-Related Disorders | 2019 |
Case 6-2019: A 29-Year-Old Woman with Nausea, Vomiting, and Diarrhea.
Topics: Acetaminophen; Adult; Buprenorphine; Cocaine-Related Disorders; Diagnosis, Differential; Diarrhea; Drug Combinations; Female; Humans; Illicit Drugs; Naloxone; Narcotic Antagonists; Nausea; Opioid-Related Disorders; Oxycodone; Substance Abuse Detection; Vomiting | 2019 |
Prescribing Trends of Codeine-containing Medications and Other Opioids in Primary Care After A Regulatory Decision: An Interrupted Time Series Analysis.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Codeine; Drug Combinations; Drug Prescriptions; Female; Humans; Interrupted Time Series Analysis; Italy; Male; Middle Aged; Naloxone; Oxycodone; Primary Health Care | 2019 |
Persistence with opioids post discharge from hospitalisation for surgery in Australian adults: a retrospective cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Australia; Databases, Factual; Drug Prescriptions; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Naloxone; Opioid-Related Disorders; Oxycodone; Pain, Postoperative; Patient Discharge; Retrospective Studies; Risk Factors; Young Adult | 2019 |
Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antibodies; Brain; Dexmedetomidine; Drug Delivery Systems; Glymphatic System; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Naloxone; Oxycodone; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2019 |
Placental trophoblast transfer of opioids following exposures to individual or mixtures of opioids
Topics: Analgesics, Opioid; Female; Fentanyl; Gas Chromatography-Mass Spectrometry; Heroin; Humans; Maternal-Fetal Exchange; Methadone; Morphine; Naloxone; Oxycodone; Placenta; Pregnancy; Trophoblasts | 2019 |
Comparing rates and characteristics of ambulance attendances related to extramedical use of pharmaceutical opioids in Victoria, Australia from 2013 to 2018.
Topics: Adolescent; Adult; Aged; Ambulances; Analgesics, Opioid; Child; Codeine; Drug Overdose; Emergency Medical Services; Female; Fentanyl; Humans; Male; Middle Aged; Morphine; Naloxone; Oxycodone; Practice Patterns, Physicians'; Prescription Drug Misuse; Retrospective Studies; Victoria; Young Adult | 2020 |
Sex differences in oral oxycodone self-administration and stress-primed reinstatement in rats.
Topics: Analgesics, Opioid; Animals; Drug-Seeking Behavior; Estrous Cycle; Extinction, Psychological; Female; Male; Naloxone; Neurokinin-1 Receptor Antagonists; Oxycodone; Prescription Drug Misuse; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Opioid, mu; Self Administration | 2020 |
The antagonistic activity profile of naloxone in μ-opioid receptor agonist-induced psychological dependence.
Topics: Analgesics, Opioid; Animals; Male; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2020 |
Acute opioid withdrawal syndrome from naloxone/naloxegol interaction.
Topics: Analgesics, Opioid; Constipation; Humans; Male; Morphinans; Naloxone; Narcotic Antagonists; Oxycodone; Polyethylene Glycols; Substance Withdrawal Syndrome | 2021 |
Foot ulcers in systemic sclerosis escape surgical amputation.
Topics: Aged; Analgesics, Opioid; Anti-Bacterial Agents; Drug Therapy, Combination; Factor Xa Inhibitors; Female; Foot Ulcer; Humans; Iloprost; Naloxone; Nifedipine; Oxycodone; Rivaroxaban; Scleroderma, Systemic; Vasodilator Agents | 2020 |
Patterns of oxycodone controlled release use in older people with cancer following public subsidy of oxycodone/naloxone formulations: An Australian population-based study.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Australia; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Naloxone; Neoplasms; Oxycodone; Retrospective Studies | 2021 |
Oxycodone stimulates normal and malignant hematopoietic progenitors via opioid-receptor-independent-β-catenin activation.
Topics: Aged; Aged, 80 and over; Antigens, CD34; beta Catenin; Cell Self Renewal; Cells, Cultured; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Receptors, Opioid; Wnt Signaling Pathway | 2020 |
Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent.
Topics: Analgesics, Opioid; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Glioblastoma; Humans; Methadone; Morphine; Naloxone; Oxycodone; Receptors, Opioid, mu; Tumor Cells, Cultured | 2021 |
Validation and characterization of oxycodone physical dependence in C57BL/6J mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice, Inbred C57BL; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Substance Withdrawal Syndrome | 2021 |
Cost-Effectiveness Analysis of Tapentadol Versus Oxycodone/Naloxone in both Branded and Generic Formulations in Patients with Musculoskeletal Pain.
Topics: Analgesics, Opioid; Cost-Benefit Analysis; Delayed-Action Preparations; Humans; Musculoskeletal Pain; Naloxone; Oxycodone; Phenols; State Medicine; Tapentadol | 2021 |
A limited access oral oxycodone paradigm produces physical dependence and mesocorticolimbic region-dependent increases in DeltaFosB expression without preference.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Locomotion; Mice; Naloxone; Narcotic Antagonists; Nociception; Nucleus Accumbens; Opioid-Related Disorders; Oxycodone; Proto-Oncogene Proteins c-fos; Substance Withdrawal Syndrome | 2022 |
Transition from Oxycodone to Buprenorphine/Naloxone in a Hospitalized Patient with Sickle Cell Disease: A Case Report.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Young Adult | 2022 |
Three cases of naloxone interference with an oxycodone immunoassay in oral fluid.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Combinations; Immunoassay; Naloxone; Narcotic Antagonists; Oxycodone | 2022 |
Opioid Antagonist Nanodrugs Successfully Attenuate the Severity of Ischemic Stroke.
Topics: Analgesics, Opioid; Animals; Ischemic Stroke; Mice; Morphine; Naloxone; Naltrexone; Nanoparticles; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Stroke; Tight Junction Proteins | 2022 |
Oxycodone/naloxone versus tapentadol in real-world chronic non-cancer pain management: an observational and pharmacogenetic study.
Topics: Analgesics, Opioid; Cancer Pain; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Morphine; Naloxone; Oxycodone; Pharmacogenomic Testing; Quality of Life; Tapentadol | 2022 |
Oxycodone-Naloxone Combination Hinders Opioid Consumption in Osteoarthritic Chronic Low Back Pain: A Retrospective Study with Two Years of Follow-Up.
Topics: Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Drug Tolerance; Follow-Up Studies; Humans; Low Back Pain; Naloxone; Narcotic Antagonists; Oxycodone; Retrospective Studies | 2022 |
Assessment of Neurotoxic Effects of Oxycodone and Naloxone in SH-SY5Y Cell Line.
Topics: Acetylcholinesterase; Analgesics, Opioid; Cell Line; Constipation; Delayed-Action Preparations; Drug Combinations; Humans; Molecular Docking Simulation; Naloxone; Neuroblastoma; Oxycodone; Pain, Postoperative; Superoxide Dismutase | 2023 |
No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury.
Topics: Analgesics, Opioid; Autonomic Dysreflexia; Chronic Pain; Constipation; Delayed-Action Preparations; Drug Combinations; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Oxycodone; Spinal Cord Injuries | 2023 |
Theophylline reverses oxycodone's but not fentanyl's respiratory depression in mice while caffeine is ineffective against both opioids.
Topics: Analgesics, Opioid; Animals; Caffeine; Fentanyl; Male; Mice; Naloxone; Narcotic Antagonists; Oxycodone; Respiratory Insufficiency; Theophylline | 2023 |
Opioid poisoning in Newcastle over the last three decades: From heroin to prescription opioids.
Topics: Adult; Analgesics, Opioid; Australia; Codeine; Female; Heroin; Humans; Male; Methadone; Naloxone; Oxycodone; Poisoning; Prescriptions | 2023 |
Oral morphine induces spinal 5-hydroxytryptamine (5-HT) release using an opioid receptor-independent mechanism.
Topics: Analgesics, Opioid; Animals; Morphine; Naloxone; Oxycodone; Pain; Rats; Receptors, Opioid; Serotonin | 2023 |