oxotremorine m has been researched along with oxotremorine in 171 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (8.77) | 18.7374 |
| 1990's | 67 (39.18) | 18.2507 |
| 2000's | 55 (32.16) | 29.6817 |
| 2010's | 31 (18.13) | 24.3611 |
| 2020's | 3 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Fraser, CM; Lai, J; Mei, L; Roeske, WR; Venter, JC; Yamamura, HI | 1 |
| Bacáková, L; El-Fakahany, EE; Jakubík, J; Tucek, S | 1 |
| Ehlert, FJ; Gerstin, EH; Luong, T | 1 |
| el-Fakahany, EE; Kiefer-Day, JS | 1 |
| Bernheim, L; Hille, B; Mathie, A | 1 |
| Ciesla, W; Li, M; Wall, SJ; Wolfe, BB; Yasuda, RP | 1 |
| Ehlert, FJ; Griffin, MT | 1 |
| Fisher, SK; Landon, RE; Lovell, SC; McEwen, EL | 1 |
| Bowers, CW; Schmidt, CJ | 1 |
| Constanti, A; Das, B; Libri, V | 1 |
| Gies, JP; Haddad, EB; Landry, Y | 1 |
| Aksoy, S; Gibson, VA; McKinney, M; Miller, JH; Nickelson, L | 1 |
| Lin, Y; Phillis, JW | 1 |
| Agranoff, BW; Fisher, SK; Hajra, AK; Lee, C | 1 |
| Beech, DJ; Bernheim, L; Hille, B; Mathie, A | 1 |
| Ballesteros, LA; Bichajian, LH; Ferrendelli, CA; Fisher, A; Hanchett, HE; Potter, LT; Zhang, R | 1 |
| Lee, W; Manning, DR; Nicklaus, KJ; Wolfe, BB | 1 |
| Duckles, SP; Ehlert, FJ; Garcia-Villalon, AL; Krause, DN | 1 |
| Cyander, M; Prusky, G | 1 |
| Delen, FM; Ehlert, FJ; Liem, HA; Yun, SH | 1 |
| Bagetta, G; Constanti, A | 1 |
| Ehlert, FJ; Rathbun, BE | 1 |
| Hirth, C; Ilien, B | 1 |
| Flynn, DD; Mash, DC | 1 |
| Baraban, JM; Heller, WA; Snyder, SH; Worley, PF | 1 |
| Anthony, BL; Aronstam, RS; Dennison, RL; Narayanan, TK | 1 |
| Choo, LK; Mitchelson, F | 1 |
| Ehlert, FJ | 3 |
| Dutar, P; Nicoll, RA | 1 |
| Alvarado-Garcia, R; Perez, LA; Witkin, JM; Witkin, KM | 1 |
| Anthony, BL; Aronstam, RS | 1 |
| Birdsall, NJ; Hulme, EC; Keen, M | 1 |
| Baker, SP; Posner, P | 1 |
| Bartus, RT; Figueiredo, JC; Fisher, SK | 1 |
| Gruener, R; He, DS; Reitstetter, R | 1 |
| Nishimura, S; Sorimachi, M; Yamagami, K | 1 |
| Eglen, RM; Reddy, H; Watson, N | 2 |
| Barnes, PJ; Belvisi, MG; Patel, HJ; Tadjkarimi, S; Takahashi, T; Yacoub, MH | 1 |
| Kostenis, E; Maass, A; Mohr, K | 1 |
| Luthin, GR; Ruggieri, MR; Wang, P | 1 |
| Atwater, I; Bordin, S; Boschero, AC; Carneiro, EM; Paul, I; Rojas, E; Szpak-Glasman, M | 1 |
| Hirschberg, BT; Schimerlik, MI | 1 |
| Fisher, SK; McEwen, EL; Palmer, RK; Williams, JA; Yule, DI | 1 |
| Bowen, WD; de Costa, BR; Kirschner, BN; Rice, KC; Tolentino, PJ; Varghese, P | 1 |
| Atwater, I; Boschero, AC; Carneiro, EM; Crepaldi, SC; Delattre, E | 1 |
| Aagaard, PJ; McKinney, M; Miller, JH | 1 |
| Ehlert, FJ; Thomas, EA | 2 |
| Qazi, S; Trimmer, BA | 2 |
| Mills, J; Reiner, PB | 1 |
| Christopoulos, A; Lanzafame, A; Mitchelson, F | 1 |
| Grudt, TJ; Henderson, G; Usowicz, MM | 1 |
| Brown, TJ; Bymaster, FP; Calligaro, DO; Dieckman, D; Greenwood, B; Hansen, K; Merrit, L; Mitch, CH; Olesen, PH; Peters, SC; Quimby, SJ; Sauerberg, P; Shannon, HE; Sheardown, MJ; Shipley, LA; Suzdak, P; Swedberg, MD; Ward, JS | 1 |
| Fisher, SK; Linseman, DA; McEwen, EL; Sorensen, SD | 1 |
| Catalán, L; Luxoro, M; Nassar-Gentina, V | 1 |
| Hille, B; Shapiro, MS; Zhou, J | 1 |
| Constanti, A; Libri, V; Postlethwaite, M; Zibetti, M | 1 |
| Luxoro, M; Nassar-Gentina, V; Rojas, E | 1 |
| Murayama, T; Nomura, Y; Yamada, T | 1 |
| Fujino, H; Kitamura, Y; Nomura, Y; Uehara, T; Yada, T | 1 |
| Schimerlik, MI; Sheehan, DM; Vogel, WK | 1 |
| Ehlert, FJ; Sawyer, GW | 2 |
| Constanti, A; Libri, V; Postlethwaite, M | 2 |
| Fisher, SK; Linseman, DA; Sorensen, SD | 1 |
| Ehlert, FJ; Ostrom, RS | 1 |
| Bowery, NG; Constanti, A; Libri, V; Postlethwaite, M | 1 |
| Ala, TA; Aldrich, SL; Anderson, LE; Bordayo, EZ; Fawcett, JR; Fraticelli, AI; Frey, WH; Johnson, MN; Kjome, JR; Klevan, LC; Swenson, KA; Venters, HD | 1 |
| Daws, LC; Overstreet, DH | 1 |
| Ehlert, F; Sawyer, G | 1 |
| Hirschberg, BT; Johnson, WC; Mosser, VA; Peterson, GL; Schimerlik, MI; Toumadje, A; Vogel, WK | 1 |
| Beech, DJ; Bernheim, L; Hille, B; Mathie, A; Shapiro, MS; Wollmuth, LP | 1 |
| Aramakis, VB; Ashe, JH; Bandrowski, AE | 1 |
| Nikbakht, MR; Stone, TW | 1 |
| Bymaster, FP; Calligaro, DO; Falcone, JF | 1 |
| Ladner, CJ; Lee, JM | 1 |
| Chahdi, A; Daeffler, L; Gies, JP; Landry, Y | 1 |
| Curtis, CA; Hulme, EC; Ward, SD | 1 |
| Abogadie, FC; Brown, DA; Hadley, JK; Jentsch, TJ; Selyanko, AA; Wood, IC | 1 |
| Daly, JW; Gupta, TH; Padgett, WL; Pei, XF | 1 |
| Ikeda, SR; Kammermeier, PJ; Ruiz-Velasco, V | 1 |
| Ballabeni, V; Barocelli, E; Bertoni, S; De Amici, M; Impicciatore, M | 1 |
| Closier, M; Howard, K; Lestage, P; Lockhart, B; Steward, C | 1 |
| de Groat, WC; Ishiura, Y; Namiki, M; Yokoyama, O; Yoshiyama, M | 1 |
| Bijur, GN; De Sarno, P; Johnson, GV; Jope, RS; Lesort, M | 1 |
| Choppin, A; Eglen, RM | 1 |
| Fujii, T; Kawashima, K | 1 |
| Gomeza, J; Meyer, A; Starke, K; Trendelenburg, AU; Wess, J; Zhou, H | 1 |
| Baldi, E; Blandina, P; Bucherelli, C; Cangioli, I; Mannaioni, PF; Passani, MB | 1 |
| Chung, YC; Dai, J; Ichikawa, J; Li, Z; Meltzer, HY | 1 |
| De Sarno, P; Jope, RS; King, TD; Shestopal, SA; Song, L; Zmijewska, A | 1 |
| Goodhead, LH; Mitchell, SN; Moss, S; Sharott, A | 1 |
| Guo, J; Schofield, GG | 1 |
| Liu, L; Rittenhouse, AR | 1 |
| Constanti, A; Postlethwaite, M | 1 |
| Aziz, M; Chintoh, A; Fulton, J; Koziel, N; Sud, M; Yeomans, JS | 1 |
| Boehm, S; Lechner, SG; Mayer, M | 1 |
| Liu, L; Rittenhouse, AR; Roberts, ML | 1 |
| Cui, Y; Duttaroy, A; Gautam, D; Mears, D; Wess, J; Zimliki, CL | 1 |
| Bukharaeva, EA; Magazanik, LG; Nikolsky, EE; Samigullin, D; Vyskocil, F | 1 |
| Abogadie, FC; Brown, DA; Filippov, AK; Hughes, S; Marsh, SJ; Tatulian, L; Winks, JS | 1 |
| Constanti, A; Postlethwaite, M; Whalley, BJ | 1 |
| Hilgemann, DW; Hille, B; Hirdes, W; Horowitz, LF; Mackie, K; Suh, BC | 1 |
| French, AS; Höger, U; Meisner, S; Panek, I; Torkkeli, PH; Widmer, A | 1 |
| Gamper, N; Hilgemann, DW; Li, Y; Shapiro, MS | 1 |
| Antony, J; Grossmüller, M; Holzgrabe, U; Mohr, K; Tränkle, C | 1 |
| Chen, SR; Gautam, D; Matsui, M; Pan, HL; Wess, J; Zhang, HM | 1 |
| Gallagher, M; Nicolle, MM; Watson, ML; Zhang, HY | 1 |
| Cruzblanca, H | 1 |
| Hille, B; Inoue, T; Meyer, T; Suh, BC | 1 |
| Ehlert, FJ; Figueroa, KW; Griffin, MT; Liller, S | 1 |
| Ahn, S; Ehlert, FJ; Matsui, M; Pak, KJ; Park, GJ; Sangnil, MS; Tran, JA | 1 |
| Margas, W; Ruiz-Velasco, V | 1 |
| Angers, S; Ma, AW; Pisterzi, LF; Redka, DS; Wells, JW | 1 |
| Boyer, SB; Clancy, SM; Slesinger, PA | 1 |
| Ano, M; Hashimotodani, Y; Kano, M; Ohno-Shosaku, T; Takeda, S; Tsubokawa, H | 1 |
| Karanth, S; Liu, J; Pope, C; Ray, A | 1 |
| Chen, SR; Gautam, D; Pan, HL; Wess, J; Zhang, HM; Zhou, HY | 1 |
| Egertová, M; Heneghan, JF; Liu, L; Michael, GJ; Rittenhouse, AR; Stanish, LF | 1 |
| Fisher, SK; Foster, DJ; Heacock, AM; Keep, RF | 1 |
| Bai, CX; Delmas, P; Downs, T; Giamarchi, A; Padilla, F; Rodat-Despoix, L; Tsiokas, L | 1 |
| Kim, Y; Lee, CJ; Lee, Y; Park, E | 1 |
| Mirajkar, N; Pope, CN | 1 |
| Banerjee, R; Fisher, SK; Foster, DJ; Heacock, AM; Vitvitsky, VM | 1 |
| Limón, A; Pérez, C; Soto, E; Vega, R | 1 |
| Cai, YQ; Chen, SR; Driver, LC; Lopez-Berestein, G; Pan, HL; Richardson, TE; Zhang, HM | 1 |
| Gandía, L; García, AG; García-Eguiagaray, J; Tapia, L | 1 |
| Azuma, H; Chancellor, MB; de Groat, WC; Kihara, K; Koga, F; Masuda, H; Sakai, Y; Yoshimura, N | 1 |
| Challiss, RA; Dean, B; Hagan, JJ; Harris, K; Pavey, G; Salah-Uddin, H; Scarr, E; Watson, JM | 1 |
| Li, L; Liu, J; Premont, RT; Rasul, I; Sun, Y; Suo, WZ; Wu, G | 1 |
| Ehlert, FJ; Griffin, MT; Matsui, M; Ostrom, RS | 1 |
| Kebig, A; Kostenis, E; Mohr, K; Mohr-Andrä, M | 1 |
| Fisher, SK; Foster, DJ; Heacock, AM | 1 |
| Dada, A; Davies, CH; Deisz, RA; Gigout, S; Hagan, JJ; Hendry, N; Jones, GA; Langmead, CJ; Thomas, DR; Watson, JM; Werry, TD | 1 |
| Ehlert, FJ; Matsui, M; Ostrom, RS; Pak, KJ | 1 |
| Fushimi, K; Harada, T; Ito, Y; Kato, A; Nishijima, S; Sugaya, K; Yamada, S | 1 |
| Bolter, CP; Han, S; Wilson, SJ | 1 |
| Bätz, J; Hoffmann, C; Lohse, MJ; Zabel, U; Ziegler, N | 1 |
| de Groat, WC; Yu, Y | 1 |
| Chen, H; Chen, SR; Pan, HL; Wess, J; Yuan, WX | 2 |
| Adem, A; Bratova, L; Fusek, J; Jun, D; Kuca, K; Kumar, UK; Proska, J; Soukup, O; Tobin, G | 1 |
| Baukrowitz, T; Bista, P; Borsotto, M; Budde, T; Cerina, M; Ehling, P; Heurteaux, C; Kanyshkova, T; Landgraf, P; Meuth, SG; Pape, HC; Pawlowski, M | 1 |
| Arenas, I; García, DE; Vivas, O | 1 |
| Dedoni, S; Ingianni, A; Olianas, MC; Onali, P | 1 |
| Caron, MG; Daigle, TL | 1 |
| Gholami, M; Hajizadeh-Moghaddam, A; Roshan-Milani, S; Saboory, E; Zare, S | 1 |
| Davis, KN; Deadwyler, SA; Hampson, RE; Howlett, AC; McQuail, JA; Miller, F; Nicolle, MM | 1 |
| Echigo, R; Kashima, K; Minami, H; Muranishi, M; Nishikawa, Y; Ohno-Shosaku, T; Sugawara, Y; Watanabe, M; Yoneda, M | 1 |
| Hansel, C; Rinaldo, L | 1 |
| Christopoulos, A; Croy, CH; Felder, CC; Quets, A; Schober, DA; Xiao, H | 1 |
| Hua, T; Li, J; Liu, M; Wang, Y; Zhang, C; Zhou, P; Zhu, Q | 1 |
| Cadaveira-Mosquera, A; Lamas, JA; Reboreda, A; Rivas-Ramírez, P | 1 |
| Hirayama, M; Ishibashi, H; Kawamata, T; Ogata, M | 1 |
| Dean, B; Gibbons, AS; Jeon, WJ; Scarr, E | 1 |
| Kikuchi, Y; Ohno-Shosaku, T; Sugawara, Y; Yoneda, M | 1 |
| Clarke, S; Reed, H; Sher, E; Zwart, R | 1 |
| Conn, PJ; Foster, DJ; Jones, CK; Lindsley, CW; Mahmood, MS; Marnett, LJ; Niswender, CM; Patel, S; Remke, DH; Rook, JM; Uddin, MJ; Wess, J; Wilson, JM; Xiang, Z | 1 |
| Belluardo, N; Borroto-Escuela, DO; Di Liberto, V; Frinchi, M; Fuxe, K; Mudò, G; Verdi, V | 1 |
| Aissaoui, A; Budde, T; Datunashvili, M; Decher, N; Leist, M; Meuth, SG; Pape, HC; Rinné, S | 1 |
| Reed, H; Sher, E; Zwart, R | 1 |
| Belluardo, N; Cappello, F; Frinchi, M; Mudò, G; Scaduto, P | 1 |
| Bonventre, JV; Liu, L; Rittenhouse, AR | 1 |
| Gillet, C; Kuenzel, T; Kurth, S | 1 |
| Cheng, L; Dai, YS; He, F; Hu, L; Huang, M; Liu, F; Said, N; Zhao, Q; Zhou, Z | 1 |
| Bai, X; Li, JF; Liu, YL; Lu, YY; Qi, YX; Su, HA; Zhang, XY | 1 |
2 review(s) available for oxotremorine m and oxotremorine
| Article | Year |
|---|---|
Functional role of M2 muscarinic receptors in the guinea pig ileum.
Topics: Animals; Colforsin; Cyclic AMP; Guinea Pigs; Heart; Histamine; Ileum; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pertussis Toxin; Piperidines; Rats; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Submandibular Gland; Virulence Factors, Bordetella | 1995 |
Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons.
Topics: Alkaloids; Animals; Calcium Channels; Furans; GTP-Binding Proteins; Muscarinic Agonists; Muscarinic Antagonists; Naphthalenes; Neurons; Oxotremorine; Patch-Clamp Techniques; Pertussis Toxin; Piperidines; Pirenzepine; Rabbits; Rats; Receptors, Muscarinic; Superior Cervical Ganglion; Virulence Factors, Bordetella | 1995 |
169 other study(ies) available for oxotremorine m and oxotremorine
| Article | Year |
|---|---|
Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells.
Topics: Alprostadil; Animals; Carbachol; Cells, Cultured; Cyclic AMP; Fibroblasts; Inositol Phosphates; Mice; Parasympatholytics; Pertussis Toxin; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1989 |
Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
Topics: Acetylcholine; Allosteric Regulation; Animals; Binding, Competitive; CHO Cells; Cricetinae; Ligands; Muscarinic Agonists; N-Methylscopolamine; Receptors, Muscarinic; Scopolamine Derivatives | 1997 |
Heparin, dextran and trypan blue allosterically modulate M2 muscarinic receptor binding properties and interfere with receptor-mediated inhibition of adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Allosteric Regulation; Animals; Dextrans; Dose-Response Relationship, Drug; Heparin; In Vitro Techniques; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives; Trypan Blue | 1992 |
Muscarinic receptor function and acetylcholinesterase activity after chronic administration of tacrine to mice at therapeutic drug concentrations.
Topics: Acetylcholinesterase; Animals; Brain; Male; Mice; Oxotremorine; Phosphatidylinositols; Receptors, Muscarinic; Tacrine | 1992 |
Inhibition of N- and L-type calcium channels by muscarinic receptor activation in rat sympathetic neurons.
Topics: Animals; Calcium Channels; Dihydropyridines; Electric Conductivity; Ganglia, Sympathetic; Male; Neurons; Norepinephrine; Oxotremorine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic | 1992 |
Differential regulation of subtypes m1-m5 of muscarinic receptors in forebrain by chronic atropine administration.
Topics: Animals; Atropine; Oxotremorine; Phosphatidylinositols; Pirenzepine; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Up-Regulation | 1992 |
Specific inhibition of isoproterenol-stimulated cyclic AMP accumulation by M2 muscarinic receptors in rat intestinal smooth muscle.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Colforsin; Cyclic AMP; Enzyme Activation; Ileum; Isoproterenol; Male; Muscle, Smooth; Oxotremorine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1992 |
Cyclic AMP potentiates receptor-stimulated phosphoinositide hydrolysis in human neuroepithelioma cells.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Cyclic AMP; Drug Synergism; Endothelins; Humans; Hydrolysis; Inositol Phosphates; Neuroectodermal Tumors, Primitive, Peripheral; Norepinephrine; Oxotremorine; Phosphatidylinositols; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Purinergic; Stimulation, Chemical; Tumor Cells, Cultured | 1992 |
Mechanisms of synaptic fatigue in a developing autonomic ganglion.
Topics: Animals; Atropine; Chick Embryo; Dose-Response Relationship, Drug; Electrophysiology; Ganglia, Sympathetic; Membrane Potentials; Naloxone; Oxotremorine; Receptors, Muscarinic | 1992 |
Ganglionic nicotinic receptor agonists exhibit anti-muscarinic effects in guinea-pig olfactory cortical brain slices.
Topics: Alkaloids; Animals; Azocines; Carbachol; Choline; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Ganglionic Stimulants; Guinea Pigs; In Vitro Techniques; Lobeline; Olfactory Bulb; Oxotremorine; Parasympatholytics; Quaternary Ammonium Compounds; Quinolizines | 1992 |
Sialic acid residues as catalysts for M2-muscarinic agonist-receptor interactions.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Carbachol; Cell Membrane; Kinetics; Male; Myocardium; Neuraminidase; Oxotremorine; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine; Sialic Acids | 1990 |
Interactions of agonists with M2 and M4 muscarinic receptor subtypes mediating cyclic AMP inhibition.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Arecoline; Bethanechol; Bethanechol Compounds; Carbachol; Cells, Cultured; CHO Cells; Corpus Striatum; Cricetinae; Cyclic AMP; Kinetics; Male; Muscarine; Oxotremorine; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Muscarinic receptor agonist-mediated modulation of neuronal activity in rat cerebral cortex.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Cerebral Cortex; Evoked Potentials; Iontophoresis; Male; Muscarinic Antagonists; Neurons; Oxotremorine; Parasympathomimetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Quantitative analysis of molecular species of diacylglycerol and phosphatidate formed upon muscarinic receptor activation of human SK-N-SH neuroblastoma cells.
Topics: Calcium; Child, Preschool; Chromatography, High Pressure Liquid; Diglycerides; Female; Humans; Kinetics; Neuroblastoma; Oxotremorine; Phosphatidic Acids; Phospholipids; Receptors, Muscarinic; Tumor Cells, Cultured | 1991 |
Intracellular Ca2+ buffers disrupt muscarinic suppression of Ca2+ current and M current in rat sympathetic neurons.
Topics: Animals; Calcium; Calcium Channels; Chelating Agents; Egtazic Acid; Fura-2; Ganglia, Sympathetic; In Vitro Techniques; Kinetics; Male; Neurons; Oxotremorine; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Spectrometry, Fluorescence | 1991 |
Evidence of paired M2 muscarinic receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Stem; Buffers; GTP-Binding Proteins; Guanine Nucleotides; Kinetics; Ligands; Male; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1991 |
Ontogeny of cortical muscarinic receptor subtypes and muscarinic receptor-mediated responses in rat.
Topics: Age Factors; Animals; Binding Sites; Cerebral Cortex; GTP-Binding Proteins; Guanosine Triphosphate; In Vitro Techniques; Oxotremorine; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic | 1990 |
Muscarinic M1 receptors stimulate phosphoinositide hydrolysis in bovine cerebral arteries.
Topics: Animals; Cattle; Cerebral Arteries; Diamines; Endothelium, Vascular; Hydrolysis; Inositol Phosphates; Kinetics; Oxotremorine; Phosphatidylinositols; Piperidines; Pirenzepine; Receptors, Muscarinic; Signal Transduction | 1990 |
The distribution of M1 and M2 muscarinic acetylcholine receptor subtypes in the developing cat visual cortex.
Topics: Animals; Autoradiography; Cats; Histocytochemistry; Oxotremorine; Pirenzepine; Radioligand Assay; Receptors, Muscarinic; Tritium; Visual Cortex | 1990 |
The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart.
Topics: Adenylyl Cyclase Inhibitors; Amitriptyline; Animals; Brain; Doxepin; Heart; Imipramine; In Vitro Techniques; Male; N-Methylscopolamine; Oxotremorine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Muscarinic suppression of the evoked N-wave by oxotremorine-M recorded in the guinea-pig olfactory cortex slice.
Topics: Action Potentials; Animals; Carbachol; Cerebral Cortex; Diamines; Electric Stimulation; Electroencephalography; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Olfactory Bulb; Oxotremorine; Parasympatholytics; Parasympathomimetics; Pirenzepine; Receptors, Muscarinic | 1990 |
Signaling through the muscarinic receptor-adenylate cyclase system of the heart is buffered against GTP over a range of concentrations.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Guanosine Triphosphate; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Direct and energy-transfer photolabelling of brain muscarinic acetylcholine receptors.
Topics: Affinity Labels; Alkylation; Animals; Azides; Brain; Diazonium Compounds; Energy Transfer; Male; Oxotremorine; Photochemistry; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Spectrophotometry | 1989 |
Multiple in vitro interactions with and differential in vivo regulation of muscarinic receptor subtypes by tetrahydroaminoacridine.
Topics: Allosteric Regulation; Aminoacridines; Animals; Brain; Cholinesterase Inhibitors; Male; Oxotremorine; Pirenzepine; Potassium Channels; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Tacrine | 1989 |
Lithium blocks a phosphoinositide-mediated cholinergic response in hippocampal slices.
Topics: Adenosine; Carbachol; Enzyme Activation; Hippocampus; Inositol Phosphates; Kinetics; Lithium; Oxotremorine; Phorbol Esters; Phosphatidylinositols; Protein Kinase C; Receptors, Muscarinic; Synapses; Synaptic Transmission | 1988 |
Effects of halothane on high affinity agonist binding and guanine nucleotide sensitivity of muscarinic acetylcholine receptors from brainstem of rat.
Topics: Animals; Brain Stem; GTP-Binding Proteins; Guanine Nucleotides; Guanylyl Imidodiphosphate; Halothane; Kinetics; Male; N-Methylscopolamine; Oxotremorine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Scopolamine Derivatives | 1987 |
Displacement of [3H]oxotremorine-M binding by muscarinic antagonists in guinea-pig atrial and ileal membrane homogenates.
Topics: Animals; Atropine; Binding, Competitive; Female; Gallamine Triethiodide; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Male; Oxotremorine; Parasympatholytics; Piperidines | 1988 |
Gallamine allosterically antagonizes muscarinic receptor-mediated inhibition of adenylate cyclase activity in the rat myocardium.
Topics: Adenylyl Cyclase Inhibitors; Algorithms; Animals; Dose-Response Relationship, Drug; Gallamine Triethiodide; Heart; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Stimulation of phosphatidylinositol (PI) turnover may mediate the muscarinic suppression of the M-current in hippocampal pyramidal cells.
Topics: Animals; Carbachol; Hippocampus; In Vitro Techniques; Inositol Phosphates; Membrane Potentials; Oxotremorine; Phosphatidylinositols; Potassium; Protein Kinase C; Rats; Receptors, Muscarinic | 1988 |
Central oxotremorine antagonist properties of pirenzepine.
Topics: Animals; Atropine Derivatives; Behavior, Animal; Dose-Response Relationship, Drug; Male; Oxotremorine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1988 |
Effects of an alkylating derivative of oxotremorine (BM 123A) on heart rate, muscarinic receptors and adenylate cyclase activity in the rabbit myocardium.
Topics: Adenylyl Cyclases; Animals; Aziridines; Azirines; Guanosine Triphosphate; Heart Rate; Male; Mathematics; Myocardium; N-Methylscopolamine; Oxotremorine; Pyrrolidinones; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
High-affinity agonist binding to rat brainstem muscarinic receptors is eliminated by low pH.
Topics: Animals; Brain Stem; Carbachol; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; Male; Oxotremorine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine | 1986 |
The binding of pirenzepine to digitonin-solubilized muscarinic acetylcholine receptors from the rat myocardium.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Cell Membrane; Centrifugation, Density Gradient; Digitonin; In Vitro Techniques; Myocardium; N-Methylscopolamine; Oxotremorine; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Solubility | 1986 |
Irreversible binding of acetylethylcholine mustard to cardiac cholinergic muscarinic receptors.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cell Membrane; Guanylyl Imidodiphosphate; Heart Rate; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1986 |
The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Guanosine Triphosphate; In Vitro Techniques; Male; Models, Structural; Myocardium; N-Methylscopolamine; Oxotremorine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1985 |
Differential stimulation of inositol phospholipid turnover in brain by analogs of oxotremorine.
Topics: Animals; Cerebral Cortex; Guinea Pigs; Inositol Phosphates; Oxotremorine; Phosphatidic Acids; Phosphatidylinositols; Quinuclidinyl Benzilate; Receptors, Muscarinic; Structure-Activity Relationship | 1984 |
Oxotremorine-M activates single nicotinic acetylcholine receptor channels in cultured Xenopus myocytes.
Topics: Animals; Cells, Cultured; Choline; Ion Channels; Membrane Potentials; Muscle, Skeletal; Oxotremorine; Receptors, Nicotinic; Xenopus laevis | 1994 |
Inability of Ca2+ influx through nicotinic ACh receptor channels to stimulate catecholamine secretion in bovine adrenal chromaffin cells: studies with fura-2 and SBFI microfluorometry.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Animals; Calcium; Calcium Channels; Catecholamines; Cations, Divalent; Cattle; Clonidine; Cytophotometry; Dose-Response Relationship, Drug; Electrophysiology; Fura-2; Gallopamil; Guanethidine; Hexamethonium; Manganese; Nicotine; Nifedipine; Oxotremorine; Receptors, Nicotinic; Sodium; Spectrometry, Fluorescence | 1994 |
Role of muscarinic M2 and M3 receptors in guinea-pig trachea: effects of receptor alkylation.
Topics: Alkylation; Animals; Diamines; Dioxolanes; Diphenylacetic Acids; Drug Interactions; Guinea Pigs; Histamine; Isoproterenol; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Receptors, Muscarinic; Stimulation, Chemical; Trachea | 1995 |
Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea.
Topics: Acetylcholine; Adolescent; Adult; Animals; Autoreceptors; Child; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Humans; In Vitro Techniques; Ipratropium; Male; Middle Aged; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Parasympathetic Nervous System; Receptors, Muscarinic; Trachea | 1995 |
Potentiation by alcuronium of the antimuscarinic effect of N-methylscopolamine in guinea pig left atria.
Topics: Alcuronium; Allosteric Regulation; Animals; Atrial Function; Binding Sites; Cholinesterase Inhibitors; Computer Simulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Isoindoles; Myocardial Contraction; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Phthalimides; Receptors, Muscarinic; Regression Analysis; Scopolamine Derivatives | 1995 |
Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins.
Topics: Animals; GTP-Binding Proteins; Humans; Muscarinic Agonists; Muscle Contraction; N-Methylscopolamine; Oxotremorine; Precipitin Tests; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Species Specificity; Urinary Bladder | 1995 |
Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors.
Topics: Animals; Base Sequence; Calcium; Drug Synergism; Extracellular Space; Female; Glucose; Insulin; Islets of Langerhans; Molecular Probes; Molecular Sequence Data; Osmolar Concentration; Oxotremorine; Potassium; Rats; Receptors, Muscarinic; RNA, Messenger | 1995 |
A kinetic model for oxotremorine M binding to recombinant porcine m2 muscarinic receptors expressed in Chinese hamster ovary cells.
Topics: Animals; CHO Cells; Cricetinae; Kinetics; Models, Biological; Oxotremorine; Receptors, Muscarinic; Recombinant Proteins; Swine | 1994 |
Agonist-specific calcium signaling and phosphoinositide hydrolysis in human SK-N-MCIXC neuroepithelioma cells.
Topics: Adenosine Triphosphate; Calcium; Endothelins; Humans; Hydrolysis; Neuroectodermal Tumors, Primitive, Peripheral; Norepinephrine; Oxotremorine; Phosphatidylinositols; Signal Transduction; Spectrometry, Fluorescence; Tumor Cells, Cultured | 1994 |
Sigma receptors and signal transduction: negative modulation of signaling through phosphoinositide-linked receptor systems.
Topics: Animals; Carbachol; Male; Oxotremorine; Pentazocine; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, sigma; Signal Transduction | 1993 |
Prolactin induces maturation of glucose sensing mechanisms in cultured neonatal rat islets.
Topics: Animals; Animals, Newborn; Calcium Radioisotopes; Cells, Cultured; Drug Synergism; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Oxotremorine; Phorbol 12,13-Dibutyrate; Potassium; Prolactin; Rats; Rubidium Radioisotopes; Tolbutamide | 1993 |
Pharmacological characterization of the rat hippocampal muscarinic autoreceptor.
Topics: Animals; Hippocampus; Kinetics; Muscarinic Antagonists; Oxotremorine; Rats; Receptors, Muscarinic | 1993 |
Involvement of the M2 muscarinic receptor in contractions of the guinea pig trachea, guinea pig esophagus, and rat fundus.
Topics: Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Esophagus; Gastric Fundus; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pertussis Toxin; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Serotonin; Trachea; Virulence Factors, Bordetella | 1996 |
Characterization of muscarinic receptor and beta-adrenoceptor interactions in guinea-pig oesophageal muscularis mucosae.
Topics: Alkylation; Animals; Esophagus; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Oxotremorine; Receptors, Adrenergic, beta; Receptors, Muscarinic | 1995 |
Modulation of second messengers in the nervous system of larval Manduca sexta by muscarinic receptors.
Topics: Abdomen; Animals; Cell-Free System; Cyclic AMP; Cyclic GMP; Female; Ganglia, Invertebrate; Inositol; Larva; Male; Manduca; Nervous System; Oxotremorine; Receptors, Muscarinic; Scopolamine; Second Messenger Systems; Tetrodotoxin | 1996 |
Phorbol esters but not the cholinergic agonists oxotremorine-M and carbachol increase release of the amyloid precursor protein in cultured rat cortical neurons.
Topics: Amyloid beta-Protein Precursor; Animals; Atropine; Carbachol; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Muscarinic Agonists; Neurons; Oxotremorine; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Signal Transduction; Tetradecanoylphorbol Acetate | 1996 |
Interactions of agonists with an allosteric antagonist at muscarinic acetylcholine M2 receptors.
Topics: Acetylcholine; Animals; Binding, Competitive; Bis-Trimethylammonium Compounds; Buffers; Carbachol; Dioxolanes; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Isoindoles; Kinetics; Male; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Receptor, Muscarinic M2; Receptors, Muscarinic | 1996 |
Ca2+ entry following store depletion in SH-SY5Y neuroblastoma cells.
Topics: Barium; Calcium; Cell Membrane Permeability; Imidazoles; Inositol 1,4,5-Trisphosphate; Lanthanum; Manganese; Muscarinic Agonists; Neuroblastoma; Neurons; Oxotremorine; Strontium; Thapsigargin; Tumor Cells, Cultured | 1996 |
Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.
Topics: Analgesics, Non-Narcotic; Animals; Colonic Diseases, Functional; Drug Design; Ferrets; Gastrointestinal Motility; Male; Mice; Muscarinic Agonists; Nociceptors; Oxotremorine | 1997 |
Agonist-induced endocytosis of muscarinic cholinergic receptors: relationship to stimulated phosphoinositide turnover.
Topics: Blotting, Western; Diglycerides; Endocytosis; Glioma; Humans; Isoenzymes; Lipid Metabolism; Muscarinic Agonists; Neuroblastoma; Oxotremorine; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Receptors, Muscarinic; Subcellular Fractions; Substrate Specificity; Tumor Cells, Cultured; Type C Phospholipases | 1997 |
Nicotinic and muscarinic components in acetylcholine stimulation of porcine adrenal medullary cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; Atropine; Calcium; Catecholamines; Cells, Cultured; Chromaffin Cells; Hexamethonium; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Receptors, Muscarinic; Receptors, Nicotinic; Swine | 1997 |
Speed of Ca2+ channel modulation by neurotransmitters in rat sympathetic neurons.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Kinetics; Membrane Potentials; Muscarinic Agonists; Neurons; Neurotransmitter Agents; Norepinephrine; Oxotremorine; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Somatostatin; Superior Cervical Ganglion | 1997 |
Metabotropic glutamate receptor subtypes mediating slow inward tail current (IADP) induction and inhibition of synaptic transmission in olfactory cortical neurones.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Guinea Pigs; Male; Muscarinic Agonists; Neurons; Olfactory Pathways; Oxotremorine; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1997 |
Deprivation of Na+, Ca2+ and Mg2+ from the extracellular solution increases cytosolic Ca2+ and stimulates catecholamine secretion from cultured bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcium; Cattle; Cell Membrane; Cells, Cultured; Chromaffin Cells; Cytosol; Inositol 1,4,5-Trisphosphate; Kinetics; Magnesium; Nicotine; Oxotremorine; Signal Transduction; Sodium; Tubocurarine | 1997 |
Muscarinic acetylcholine receptors on rat thymocytes: their possible involvement in DNA fragmentation.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Atropine; Binding, Competitive; Carbachol; DNA Fragmentation; Electrophoresis, Agar Gel; Hydrocortisone; Injections, Subcutaneous; Isotope Labeling; Male; Muscarinic Agonists; Muscarinic Antagonists; Nucleosomes; Oxotremorine; Piperidines; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Thymus Gland | 1997 |
Stimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes.
Topics: Antigens, CD; Calcium; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Division; Cyclosporine; DNA; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Muscarinic Agonists; Oxotremorine; Phytohemagglutinins; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; Receptors, Muscarinic; RNA, Messenger; Tacrolimus | 1997 |
Site-directed mutagenesis on the m2 muscarinic acetylcholine receptor: the significance of Tyr403 in the binding of agonists and functional coupling.
Topics: Acetylcholine; Animals; Binding Sites; Carbachol; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; Mutagenesis, Site-Directed; Mutation; Oxotremorine; Receptor, Muscarinic M2; Receptors, Muscarinic; Tyrosine | 1997 |
Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon.
Topics: Animals; Colforsin; Colon; Cyclic AMP; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Oxotremorine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Virulence Factors, Bordetella | 1998 |
Muscarinic agonist-induced burst firing in immature rat olfactory cortex neurons In vitro.
Topics: 4-Aminopyridine; Animals; Cellular Senescence; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Male; Membrane Potentials; Muscarinic Agonists; Olfactory Bulb; Oxotremorine; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Respiratory Burst | 1998 |
Down-regulation of phospholipase C-beta1 following chronic muscarinic receptor activation.
Topics: Down-Regulation; GTP-Binding Proteins; Humans; Isoenzymes; Muscarinic Agonists; Oxotremorine; Phospholipase C beta; Receptors, Muscarinic; Tumor Cells, Cultured; Type C Phospholipases | 1998 |
M2 muscarinic receptors inhibit forskolin- but not isoproterenol-mediated relaxation in bovine tracheal smooth muscle.
Topics: Animals; Cattle; Colforsin; Cyclic AMP; Diphenylacetic Acids; Histamine; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Muscle, Smooth; Oxotremorine; Piperidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Trachea | 1998 |
Blockade of GABA(B) receptors facilitates muscarinic agonist-induced epileptiform activity in immature rat piriform cortex in vitro.
Topics: Animals; Benzylamines; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; GABA-B Receptor Antagonists; Male; Membrane Potentials; Muscarinic Agonists; Neurons; Neuroprotective Agents; Oxotremorine; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Synaptic Transmission | 1998 |
Inhibition of antagonist and agonist binding to the human brain muscarinic receptor by arachidonic acid.
Topics: Adult; Arachidonic Acids; Chromans; Fatty Acids; Feedback; Frontal Lobe; Glutathione; Humans; Kinetics; Manganese; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Oxotremorine; Palmitic Acid; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1998 |
Ontogeny of muscarinic cholinergic supersensitivity in the Flinders Sensitive Line rat.
Topics: Animals; Binding Sites; Body Temperature; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hippocampus; Hypothalamus; Male; Motor Activity; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Quinuclidinyl Benzilate; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic; Scopolamine; Visual Cortex | 1999 |
Pertussis toxin increases isoproterenol induced relaxation in field-stimulated ileum.
Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Histamine; Histamine Agonists; Ileum; In Vitro Techniques; Isoproterenol; Male; Muscarinic Agonists; Muscle Contraction; Muscle Relaxation; Oxotremorine; Pertussis Toxin; Sympathomimetics; Virulence Factors, Bordetella | 1999 |
Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions.
Topics: Animals; Colon; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Models, Biological; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Virulence Factors, Bordetella | 1999 |
Kinetic and biophysical analysis of the m2 muscarinic receptor.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Circular Dichroism; Cricetinae; Cyclic AMP; Kinetics; Ligands; Muscarinic Agonists; Oxotremorine; Protein Structure, Secondary; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Proteins; Spectrophotometry, Ultraviolet; Transfection | 1995 |
Role of muscarinic receptors, G-proteins, and intracellular messengers in muscarinic modulation of NMDA receptor-mediated synaptic transmission.
Topics: Animals; Auditory Cortex; Calcium Channels; Excitatory Postsynaptic Potentials; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Male; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Cytoplasmic and Nuclear; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Synaptic Transmission; Thionucleotides | 1999 |
Occlusive responses to adenosine A1 receptor and muscarinic M2 receptor activation on hippocampal presynaptic terminals.
Topics: Adenosine; Animals; Hippocampus; In Vitro Techniques; Male; Muscarinic Agonists; Oxotremorine; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptor, Muscarinic M2; Receptors, Muscarinic | 1999 |
Arachidonic acid release in cell lines transfected with muscarinic receptors: a simple functional assay to determine response of agonists.
Topics: Animals; Arachidonic Acid; Calcium; Chelating Agents; CHO Cells; Cricetinae; Egtazic Acid; Humans; Hydrolysis; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Pirenzepine; Receptors, Muscarinic; Time Factors; Transfection | 1999 |
Reduced high-affinity agonist binding at the M(1) muscarinic receptor in Alzheimer's disease brain: differential sensitivity to agonists and divalent cations.
Topics: Acetylcholine; Aged; Alzheimer Disease; Brain; Carbachol; Cations, Divalent; Chlorides; Edetic Acid; Female; Guanylyl Imidodiphosphate; Humans; Kinetics; Magnesium Chloride; Male; Manganese Compounds; Muscarinic Agonists; Oxotremorine; Pirenzepine; Receptor, Muscarinic M1; Receptors, Muscarinic; Reference Values | 1999 |
Inhibition of GTPase activity of Gi proteins and decreased agonist affinity at M2 muscarinic acetylcholine receptors by spermine and methoctramine.
Topics: Animals; Diamines; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Organ Specificity; Oxotremorine; Rats; Receptor, Muscarinic M2; Receptors, Muscarinic; Spermine; Swine | 1999 |
Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function.
Topics: Acetylcholine; Alanine; Animals; Atropine; Binding, Competitive; COS Cells; Immunohistochemistry; Ligands; Muscarinic Agonists; Muscarinic Antagonists; Mutagenesis, Site-Directed; N-Methylscopolamine; Oxotremorine; Phosphatidylinositols; Pilocarpine; Protein Structure, Tertiary; Quinuclidinyl Benzilate; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Tyrosine | 1999 |
The role of nitric oxide in motoneuron spike activity and muscarinic-evoked changes in cGMP in the CNS of larval Manduca sexta.
Topics: Action Potentials; Animals; Central Nervous System; Cyclic GMP; Enzyme Inhibitors; Female; Guanylate Cyclase; Larva; Male; Manduca; Motor Neurons; Muscarine; Muscarinic Agonists; Nitric Oxide; Nitric Oxide Synthase; Oxotremorine | 1999 |
Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors.
Topics: Animals; CHO Cells; Cricetinae; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Muscarinic Agonists; Oxotremorine; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Receptor, Muscarinic M1; Receptors, Muscarinic; Stimulation, Chemical; Transfection | 2000 |
Investigation of the role of intracellular Ca(2+) stores in generation of the muscarinic agonist-induced slow afterdepolarization (sADP) in guinea-pig olfactory cortical neurones in vitro.
Topics: Action Potentials; Animals; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; In Vitro Techniques; Indoles; Male; Membrane Potentials; Muscarinic Agonists; Neurons; Nifedipine; Olfactory Pathways; Oxotremorine; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Ryanodine; Ryanodine Receptor Calcium Release Channel; Synaptic Transmission; Thapsigargin | 2000 |
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Topics: Adenylyl Cyclase Inhibitors; Animals; Binding Sites; Cerebral Cortex; CHO Cells; Cricetinae; Humans; In Vitro Techniques; Muscarinic Agonists; Myocardium; Oxotremorine; Quinuclidinyl Benzilate; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptors, Muscarinic; Transfection; Tropanes | 2000 |
A voltage-independent calcium current inhibitory pathway activated by muscarinic agonists in rat sympathetic neurons requires both Galpha q/11 and Gbeta gamma.
Topics: Animals; Buffers; Calcium; Calcium Channels, N-Type; Cells, Cultured; Elapid Venoms; Electric Stimulation; Electrophysiology; Gene Expression; Genes, Reporter; Green Fluorescent Proteins; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Indicators and Reagents; Ion Channel Gating; Isoenzymes; Luminescent Proteins; Muscarinic Agonists; Muscarinic Antagonists; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neurons; Oxotremorine; Pertussis Toxin; Phospholipase C beta; Rats; Rats, Wistar; Receptors, Neurokinin-1; Recombinant Proteins; RGS Proteins; Superior Cervical Ganglion; Type C Phospholipases; Virulence Factors, Bordetella | 2000 |
Evidence for specific analgesic activity of a muscarinic agonist selected among a new series of acetylenic derivatives.
Topics: Acetylene; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Male; Mice; Muscarinic Agonists; Oxotremorine; Rats; Receptors, Muscarinic | 2001 |
Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors.
Topics: Animals; Binding Sites; Brain; Cholinesterase Inhibitors; Elapid Venoms; Electrophorus; Muscarinic Agonists; Oxotremorine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic | 2001 |
Central muscarinic mechanisms regulating voiding in rats.
Topics: Animals; Atropine; Brain; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Injections, Intraventricular; Injections, Spinal; Manometry; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Oxotremorine; Rats; Receptors, Muscarinic; Spinal Cord; Urinary Bladder; Urination | 2001 |
Cholinergic- and stress-induced signaling activities in cells overexpressing wild-type and mutant presenilin-1.
Topics: Acetylcholine; Gene Expression; Heat-Shock Response; Humans; Membrane Proteins; Muscarinic Agonists; Neuroblastoma; Oxidative Stress; Oxotremorine; Presenilin-1; Receptors, Muscarinic; Signal Transduction; Tumor Cells, Cultured | 2001 |
Pharmacological characterization of muscarinic receptors in mouse isolated urinary bladder smooth muscle.
Topics: Acetylcholine; Animals; Carbachol; Diamines; Dioxolanes; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pilocarpine; Piperidines; Receptors, Muscarinic; Urinary Bladder | 2001 |
YM905, a novel M3 antagonist, inhibits Ca2+ signaling and c-fos gene expression mediated via muscarinic receptors in human T cells.
Topics: Calcium Signaling; Cells, Cultured; Genes, fos; Humans; Isoquinolines; Muscarinic Antagonists; Oxotremorine; Quinuclidines; Receptor, Muscarinic M3; Receptors, Muscarinic; RNA, Messenger; Solifenacin Succinate; T-Lymphocytes; Tetrahydroisoquinolines | 2000 |
Heterogeneity of release-inhibiting muscarinic autoreceptors in heart atria and urinary bladder: a study with M(2)- and M(4)-receptor-deficient mice.
Topics: Animals; Autoreceptors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Female; Heart Atria; In Vitro Techniques; Male; Mice; Mice, Knockout; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic; Urinary Bladder | 2002 |
Activation of histaminergic H3 receptors in the rat basolateral amygdala improves expression of fear memory and enhances acetylcholine release.
Topics: Acetylcholine; Amygdala; Animals; Cholinesterase Inhibitors; Conditioning, Psychological; Dose-Response Relationship, Drug; Fear; Histamine; Histamine Agonists; Imidazoles; Male; Memory; Methylhistamines; Muscarinic Agonists; Neurons; Oxotremorine; Piperidines; Rats; Rats, Wistar; Receptors, Histamine H3; Synaptic Transmission | 2002 |
Cholinergic modulation of basal and amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens.
Topics: Acetylcholine; Adrenergic Uptake Inhibitors; Amphetamine; Animals; Cognition Disorders; Dopamine; Male; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Nucleus Accumbens; Oxotremorine; Parasympatholytics; Pirenzepine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Schizophrenia; Scopolamine | 2002 |
Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition.
Topics: Apoptosis; Camptothecin; Cytochrome c Group; DNA Damage; Humans; Hydrogen Peroxide; Mitochondria; Oxidative Stress; Oxotremorine; Proto-Oncogene Proteins c-bcl-2; Receptors, Muscarinic; Tumor Cells, Cultured | 2003 |
Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens.
Topics: Animals; Atropine; Bicuculline; Bridged-Ring Compounds; Carbachol; Cholinergic Agonists; Diamines; Dopamine; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nucleus Accumbens; Oxotremorine; Pilocarpine; Pyridines; Rats; Receptors, Muscarinic; Spiro Compounds; Thiadiazoles; Tropanes | 2003 |
Activation of muscarinic m5 receptors inhibits recombinant KCNQ2/KCNQ3 K+ channels expressed in HEK293T cells.
Topics: Cell Line; Cholera Toxin; Gene Expression; GTP-Binding Proteins; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Potentials; Oxotremorine; Pertussis Toxin; Potassium Channels; Potassium Channels, Voltage-Gated; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptor, Muscarinic M5; Receptors, Muscarinic; Transfection | 2003 |
Pharmacological discrimination between muscarinic receptor signal transduction cascades with bethanechol chloride.
Topics: Animals; Animals, Newborn; Bethanechol; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Signaling; Egtazic Acid; Muscarinic Agonists; Oxotremorine; Patch-Clamp Techniques; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Signal Transduction; Superior Cervical Ganglion | 2003 |
Evidence for the involvement of G-proteins in the generation of the slow poststimulus afterdepolarisation (sADP) induced by muscarinic receptor activation in rat olfactory cortical neurones in vitro.
Topics: Animals; Animals, Newborn; Baclofen; Barium; Drug Interactions; GABA Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membrane Potentials; Muscarinic Agonists; Neural Conduction; Neurons; Olfactory Pathways; Oxotremorine; Patch-Clamp Techniques; Rats; Rats, Wistar; Time Factors | 2003 |
Role of cholinergic receptors in locomotion induced by scopolamine and oxotremorine-M.
Topics: Animals; Locomotion; Male; Oxotremorine; Rats; Rats, Wistar; Receptors, Cholinergic; Scopolamine | 2003 |
Activation of M1 muscarinic receptors triggers transmitter release from rat sympathetic neurons through an inhibition of M-type K+ channels.
Topics: Animals; Animals, Newborn; Carbamates; Cells, Cultured; Evoked Potentials; Mecamylamine; Membrane Potentials; Muscarinic Agonists; Neurons; Norepinephrine; Oxotremorine; Pertussis Toxin; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Superior Cervical Ganglion; Tetrodotoxin | 2003 |
Phospholipid metabolism is required for M1 muscarinic inhibition of N-type calcium current in sympathetic neurons.
Topics: Animals; Arachidonic Acid; Calcium Channels, N-Type; Electrophysiology; GTP-Binding Proteins; Kinetics; Lysophospholipids; Muscarinic Agonists; Neurons; Oxotremorine; Pertussis Toxin; Phospholipases; Phospholipids; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Superior Cervical Ganglion | 2004 |
Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice.
Topics: Animals; Blood Glucose; Glucagon; Insulin; Insulin Secretion; Mice; Mice, Knockout; Muscarinic Agonists; Oxotremorine; Pancreas; Receptor, Muscarinic M3; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
Cholinergic regulation of the evoked quantal release at frog neuromuscular junction.
Topics: Acetylcholine; Action Potentials; Animals; Arecoline; Carbachol; Cholinergic Agonists; Diamines; Motor Neurons; Muscarinic Agonists; Muscarinic Antagonists; Neural Conduction; Neuromuscular Junction; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Parasympatholytics; Pirenzepine; Rana ridibunda; Receptors, Muscarinic; Synaptic Transmission; Tubocurarine | 2004 |
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels.
Topics: Animals; Animals, Newborn; Bradykinin; Calcium; Calcium-Binding Proteins; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Estrenes; Female; Fluorescent Dyes; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Gene Expression; Green Fluorescent Proteins; Immunohistochemistry; Isoenzymes; Male; Microscopy, Confocal; Muscarinic Agonists; Mutation; Neural Inhibition; Neuronal Calcium-Sensor Proteins; Neurons; Neuropeptides; Oxotremorine; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Phospholipase C delta; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Superior Cervical Ganglion; Transfection; Type C Phospholipases | 2005 |
Further characterization of muscarinic agonist-induced epileptiform bursting activity in immature rat piriform cortex, in vitro.
Topics: Animals; Brain; Cell Membrane; Epilepsy; Female; In Vitro Techniques; Male; Muscarinic Agonists; Neurons; Olfactory Pathways; Oxotremorine; Rats; Rats, Sprague-Dawley | 2005 |
Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current.
Topics: Alkylation; Animals; Calcium; CHO Cells; Cricetinae; Enzyme Activation; Estrenes; Ethylmaleimide; Humans; Inositol Phosphates; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Membrane Potentials; Muscarinic Agonists; Oxotremorine; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipid Ethers; Potassium Channels, Voltage-Gated; Protein Kinase C; Pyrrolidinones; Receptor, Muscarinic M1; Sulfonamides; Time Factors; Transfection | 2005 |
Acetylcholine receptors in spider peripheral mechanosensilla.
Topics: Acetylcholine; Action Potentials; Animals; Blotting, Western; Female; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Mechanoreceptors; Mechanotransduction, Cellular; Membrane Potentials; Microscopy, Confocal; Muscarinic Agonists; Neurons, Afferent; Neurons, Efferent; Neurotransmitter Agents; Oxotremorine; Receptors, Cholinergic; Spiders | 2006 |
Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate.
Topics: Animals; Carbachol; CHO Cells; Cholinergic Agonists; Cloning, Molecular; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Electric Stimulation; Extracellular Space; Green Fluorescent Proteins; Humans; Ion Channel Gating; KCNQ Potassium Channels; Membrane Potentials; Muscarinic Agonists; Oncogene Protein v-akt; Oxotremorine; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Phosphotransferases (Alcohol Group Acceptor); Probability; src-Family Kinases; Structure-Activity Relationship; Transfection | 2005 |
Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist.
Topics: Allosteric Regulation; Allosteric Site; Animals; Binding, Competitive; Gallamine Triethiodide; In Vitro Techniques; Isoindoles; Muscarinic Agonists; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Obidoxime Chloride; Oxotremorine; Phthalimides; Protein Conformation; Pyridinium Compounds; Receptor, Muscarinic M2; Swine | 2006 |
Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice.
Topics: Alkaloids; Animals; Electrophysiology; Furans; gamma-Aminobutyric Acid; Mice; Mice, Knockout; Muscarinic Agonists; Muscarinic Antagonists; Naphthalenes; Neurons; Oxotremorine; Piperidines; Posterior Horn Cells; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Spinal Cord | 2006 |
Muscarinic receptor-mediated GTP-Eu binding in the hippocampus and prefrontal cortex is correlated with spatial memory impairment in aged rats.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Behavior, Animal; Cell Membrane; Dose-Response Relationship, Drug; Guanosine Triphosphate; Hippocampus; Male; Maze Learning; Memory Disorders; Muscarinic Agonists; Oxotremorine; Prefrontal Cortex; Protein Binding; Rats; Rats, Long-Evans; Receptors, Muscarinic; Space Perception | 2007 |
An M2-like muscarinic receptor enhances a delayed rectifier K+ current in rat sympathetic neurones.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Bethanechol; Cells, Cultured; Delayed Rectifier Potassium Channels; Furans; Membrane Potentials; Muscarinic Agonists; Muscarinic Antagonists; Naphthalenes; Neurons; Oxotremorine; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptor, Muscarinic M2; Superior Cervical Ganglion | 2006 |
Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Diglycerides; Dimerization; Humans; Inositol Polyphosphate 5-Phosphatases; Ion Channel Gating; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mice; NIH 3T3 Cells; Oxotremorine; Phosphatidylinositol 4,5-Diphosphate; Phosphoric Monoester Hydrolases; Phosphorylation; Recombinant Fusion Proteins; Second Messenger Systems; Sirolimus | 2006 |
Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Algorithms; Animals; Carbachol; Cell Line; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Diphenylacetic Acids; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Heterotrimeric GTP-Binding Proteins; Humans; Isoproterenol; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Piperidines; Pirenzepine; Quinuclidines; Receptor, Muscarinic M2; Signal Transduction; Transfection | 2007 |
Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladder.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Cholinergic Fibers; Dinoprost; Electric Stimulation; Female; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscle Contraction; Oxotremorine; Physostigmine; Potassium Chloride; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Serotonin; Tetrodotoxin; Urinary Bladder | 2007 |
Electrophysiological and immunofluorescence characterization of Ca(2+) channels of acutely isolated rat sphenopalatine ganglion neurons.
Topics: Acetylcholinesterase; Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Calcium Channels; Cells, Cultured; Electrophysiology; Fluorescent Antibody Technique; Ganglia, Parasympathetic; Head; Male; Muscarinic Agonists; Neurons; Norepinephrine; Oxotremorine; Patch-Clamp Techniques; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 2007 |
Recovery of oligomers and cooperativity when monomers of the M2 muscarinic cholinergic receptor are reconstituted into phospholipid vesicles.
Topics: Animals; Guanylyl Imidodiphosphate; Humans; Ligands; Liposomes; N-Methylscopolamine; Oxotremorine; Phospholipids; Protein Structure, Quaternary; Quinuclidinyl Benzilate; Receptor, Muscarinic M2; Spodoptera | 2007 |
Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.
Topics: Analysis of Variance; Animals; Cell Differentiation; Endocytosis; Enzyme Inhibitors; G Protein-Coupled Inwardly-Rectifying Potassium Channels; gamma-Aminobutyric Acid; Membrane Potentials; Muscarinic Agonists; Muscarinic Antagonists; Nerve Growth Factor; Oxotremorine; Patch-Clamp Techniques; PC12 Cells; Rats; Receptor, Muscarinic M2; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2007 |
Endocannabinoid signalling triggered by NMDA receptor-mediated calcium entry into rat hippocampal neurons.
Topics: Animals; Animals, Newborn; Calcium Channels; Calcium Signaling; Cannabinoid Receptor Modulators; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Endocannabinoids; Excitatory Amino Acid Agonists; Glycine; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Inhibitory Postsynaptic Potentials; Lipoprotein Lipase; Morpholines; Muscarinic Agonists; N-Methylaspartate; Neurons; Oxotremorine; Phospholipase C beta; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Resorcinols | 2007 |
Comparative in vivo effects of parathion on striatal acetylcholine accumulation in adult and aged rats.
Topics: Acetylcholine; Aging; Animals; Binding, Competitive; Cholinesterase Inhibitors; Corpus Striatum; Defecation; Diaphragm; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Male; Motor Activity; Muscarinic Antagonists; Neostigmine; Oxotremorine; Parathion; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Salivation; Tritium; Urination; Weight Loss | 2007 |
Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice.
Topics: Animals; Electrophysiology; Glycine; In Vitro Techniques; Mice; Mice, Knockout; Muscarinic Agonists; Oxotremorine; Pertussis Toxin; Posterior Horn Cells; Protein Subunits; Receptors, Muscarinic; Spinal Cord; Synaptic Transmission | 2007 |
L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity.
Topics: Animals; Arachidonic Acids; Calcium Channels, L-Type; Calcium Channels, N-Type; Cells, Cultured; Cyclohexanones; Humans; In Situ Hybridization; Lipoprotein Lipase; Muscarinic Agonists; Neurons; Oxotremorine; Patch-Clamp Techniques; Pertussis Toxin; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Muscarinic M1; Recombinant Proteins; Superior Cervical Ganglion | 2008 |
Activation of muscarinic cholinergic receptors on human SH-SY5Y neuroblastoma cells enhances both the influx and efflux of K+ under conditions of hypo-osmolarity.
Topics: Calcium; Cell Line, Tumor; Humans; Muscarinic Agonists; Osmolar Concentration; Oxotremorine; Potassium; Protein Kinase C; Receptors, Muscarinic; Rubidium Radioisotopes; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Water | 2008 |
Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits.
Topics: Amiloride; Animals; Cell Line; Cells, Cultured; Cilia; Ion Channels; Kidney; Lanthanoid Series Elements; LLC-PK1 Cells; Mice; Muscarinic Agonists; Neurons; Oxotremorine; Protein Subunits; Rats; Receptors, G-Protein-Coupled; Sodium Channel Blockers; Swine; TRPP Cation Channels | 2008 |
Cholinergic modulation of neural activity in the telencephalon of the zebrafish.
Topics: Acetylcholine; Analysis of Variance; Animals; Cholinergic Agents; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Functional Laterality; In Vitro Techniques; Muscarinic Agonists; Neurons; Oxotremorine; Patch-Clamp Techniques; Telencephalon; Time Factors; Zebrafish | 2008 |
In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases.
Topics: Acetylcholinesterase; Aging; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinesterase Inhibitors; Heart; Male; Myocardium; Organophosphorus Compounds; Oxotremorine; Rats; Rats, Sprague-Dawley; Tritium | 2008 |
Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells.
Topics: Alanine; Antioxidants; Biological Transport; Calcium; Cell Line, Tumor; Cyclopentanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidine; Humans; Indans; Lysophospholipids; Muscarinic Agonists; Neuroblastoma; Osmolar Concentration; Oxotremorine; Receptors, Muscarinic; Saline Solution, Hypertonic; Sphingosine; Taurine; Thapsigargin; Thrombin; Tritium | 2009 |
The muscarinic inhibition of the potassium M-current modulates the action-potential discharge in the vestibular primary-afferent neurons of the rat.
Topics: Action Potentials; Animals; Animals, Newborn; Anthracenes; Atropine; Biophysical Phenomena; Calcium Channel Blockers; Cells, Cultured; Indoles; Muscarinic Agonists; Muscarinic Antagonists; Neurons, Afferent; Oxotremorine; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Wistar; Receptors, Muscarinic; Vestibule, Labyrinth | 2009 |
Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord.
Topics: Animals; Anthracenes; Biophysics; Cadmium; Calcium; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Gene Expression Regulation; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Male; Muscarinic Agonists; Neural Inhibition; Neurons; Nickel; Oxotremorine; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Spinal Cord | 2009 |
Preconditioning stimuli that augment chromaffin cell secretion.
Topics: Acetylcholine; Adrenal Glands; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Catecholamines; Cattle; Cells, Cultured; Choline; Chromaffin Cells; Dose-Response Relationship, Drug; Mecamylamine; Methacholine Chloride; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Potassium; Pyridines; Receptors, Muscarinic; Receptors, Nicotinic; Sympathetic Nervous System; Time Factors | 2009 |
Effects of cholinesterase inhibition in supraspinal and spinal neural pathways on the micturition reflex in rats.
Topics: Administration, Intravesical; Animals; Brain; Capsaicin; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Injections, Spinal; Muscarinic Agonists; Neostigmine; Neural Pathways; Oxotremorine; Rats; Rats, Sprague-Dawley; Sensory System Agents; Spinal Cord; Urination | 2009 |
Altered M(1) muscarinic acetylcholine receptor (CHRM1)-Galpha(q/11) coupling in a schizophrenia endophenotype.
Topics: Adult; Aged; Cell Membrane; Female; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Phenotype; Piperidines; Pirenzepine; Prefrontal Cortex; Protein Binding; Receptor, Muscarinic M1; Receptors, Muscarinic; Schizophrenia; Sulfur Radioisotopes; Tritium; Young Adult | 2009 |
GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.
Topics: Acetylcholine; Animals; Autoreceptors; Blotting, Western; Cell Line; Endocytosis; G-Protein-Coupled Receptor Kinase 5; Gene Expression; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; Membrane Proteins; Mice; Mice, Knockout; Oxotremorine; Pertussis Toxin; Potassium; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Synapses; Transfection | 2009 |
The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum.
Topics: Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Species Specificity | 2009 |
An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators.
Topics: Acetylcholine; Animals; Atropine; Biosensing Techniques; Carbachol; Cell Line; CHO Cells; Cholinergic Agonists; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Receptors, G-Protein-Coupled; Signal Transduction | 2009 |
Muscarinic receptor stimulation of D-aspartate uptake into human SH-SY5Y neuroblastoma cells is attenuated by hypoosmolarity.
Topics: Calcium; Cell Line, Tumor; Cell Membrane; Cytoskeleton; D-Aspartic Acid; Excitatory Amino Acid Transporter 3; Humans; Muscarinic Agonists; Neuroblastoma; Neurons; Osmolar Concentration; Osmosis; Oxotremorine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Receptors, Muscarinic | 2010 |
N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M(1) receptor.
Topics: Action Potentials; Animals; Calcium; Clozapine; Drug Partial Agonism; Hippocampus; Humans; In Vitro Techniques; Neocortex; Oxotremorine; Protein Binding; Radioligand Assay; Rats; Receptor, Muscarinic M1; Recombinant Proteins | 2010 |
Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder.
Topics: Animals; Colforsin; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscle Contraction; Oxotremorine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Streptozocin; Time Factors; Urinary Bladder | 2010 |
Demonstration of muscarinic and nicotinic receptor binding activities of distigmine to treat detrusor underactivity.
Topics: Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Cholinesterase Inhibitors; Down-Regulation; Male; Muscarinic Agonists; Muscle, Smooth; Oxotremorine; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Submandibular Gland; Urinary Bladder; Urinary Bladder Diseases | 2010 |
Tertiapin-Q removes a mechanosensitive component of muscarinic control of the sinoatrial pacemaker in the rat.
Topics: Animals; Atrial Function, Right; Bee Venoms; Biological Clocks; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Male; Mechanoreceptors; Muscarinic Agonists; Oxotremorine; Potassium Channel Blockers; Rats; Rats, Wistar; Receptors, Muscarinic; Sinoatrial Node | 2010 |
FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors.
Topics: Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Green Fluorescent Proteins; HEK293 Cells; Humans; Kinetics; Ligands; Microscopy, Confocal; Muscarinic Agonists; Oxotremorine; Protein Conformation; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptor, Muscarinic M5; Signal Transduction; Stereoisomerism | 2011 |
Effects of stimulation of muscarinic receptors on bladder afferent nerves in the in vitro bladder-pelvic afferent nerve preparation of the rat.
Topics: Action Potentials; Adenosine Triphosphate; Administration, Intravesical; Animals; Atropine Derivatives; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Muscarinic Agonists; Muscle Contraction; Neurons, Afferent; Oxotremorine; Parasympatholytics; Purinergic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sensory System Agents; Urinary Bladder | 2010 |
Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice.
Topics: Alkaloids; Alkenes; Animals; Furans; Glutamic Acid; Mice; Mice, Knockout; Muscarinic Agonists; Naphthalenes; Oxotremorine; Parasympatholytics; Piperidines; Posterior Horn Cells; Receptors, Muscarinic; Spinal Cord; Synapses; Synaptic Transmission | 2010 |
The effect of oxime reactivators on muscarinic receptors: functional and binding examinations.
Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Electric Stimulation; Heart Rate; Muscarinic Agonists; Muscarinic Antagonists; Oximes; Oxotremorine; Pyridinium Compounds; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Muscarinic | 2011 |
Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons.
Topics: Action Potentials; Animals; Cholinergic Neurons; Electrophysiological Phenomena; Gene Expression; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen-Ion Concentration; Lateral Thalamic Nuclei; Membrane Potentials; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Nerve Tissue Proteins; Oxotremorine; Patch-Clamp Techniques; Phospholipase C beta; Potassium Channels, Tandem Pore Domain; Rats; Rats, Long-Evans; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Signal Transduction; Sleep; Thalamus; Thionucleotides | 2012 |
Voltage-independent inhibition of Ca(V)2.2 channels is delimited to a specific region of the membrane potential in rat SCG neurons.
Topics: Animals; Calcium Channels, N-Type; Cells, Cultured; Male; Membrane Potentials; Muscarinic Agonists; Norepinephrine; Oxotremorine; Rats; Rats, Wistar; Superior Cervical Ganglion | 2012 |
Type I interferons impair BDNF-induced cell signaling and neurotrophic activity in differentiated human SH-SY5Y neuroblastoma cells and mouse primary cortical neurons.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Survival; Cells, Cultured; Drug Interactions; Female; Frontal Lobe; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Interferon Type I; Male; Mice; Muscarinic Agonists; Neuroblastoma; Neurogenesis; Neurons; Oncogene Protein v-akt; Oxotremorine; Phosphorylation; RNA, Small Interfering; Signal Transduction; Transfection | 2012 |
Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation.
Topics: Analysis of Variance; Animals; Body Temperature; Brain; Choline O-Acetyltransferase; Cholinergic Neurons; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; G-Protein-Coupled Receptor Kinase 2; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Muscarinic Agonists; Oxotremorine; Pain Threshold; Receptors, Muscarinic; Salivation | 2012 |
The effect of dorsal hippocampal administration of nicotinic and muscarinic cholinergic ligands on pentylenetetrazol-induced generalized seizures in rats.
Topics: Animals; Atropine; Hippocampus; Male; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Oxotremorine; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2012 |
Hippocampal Gαq/₁₁ but not Gαo-coupled receptors are altered in aging.
Topics: Aging; Animals; Baclofen; CA1 Region, Hippocampal; Calcium; Excitatory Amino Acid Agonists; GABA-B Receptor Agonists; Glycine; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Learning; Male; Muscarinic Agonists; Oxotremorine; Rats; Resorcinols; Spatial Behavior | 2013 |
Intracellular calcium level is an important factor influencing ion channel modulations by PLC-coupled metabotropic receptors in hippocampal neurons.
Topics: Animals; Animals, Newborn; Anthracenes; Apamin; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hippocampus; Intracellular Fluid; Ion Channels; Methoxyhydroxyphenylglycol; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Oxotremorine; Patch-Clamp Techniques; Pirenzepine; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Time Factors; Type C Phospholipases | 2013 |
Muscarinic acetylcholine receptor activation blocks long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses via cannabinoid signaling.
Topics: Animals; Cannabinoids; Cerebellum; Long-Term Potentiation; Mice; Mice, Knockout; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Muscarinic; Signal Transduction; Synapses | 2013 |
Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice.
Topics: Animals; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Mice; Mice, Knockout; Oxotremorine; Posterior Horn Cells; Receptors, Muscarinic; Spinal Nerve Roots | 2014 |
Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors.
Topics: Allosteric Regulation; Allosteric Site; Animals; Cell Line; CHO Cells; Cricetulus; GTP-Binding Proteins; Humans; Ligands; Muscarinic Agonists; Oxotremorine; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Signal Transduction | 2014 |
Muscarinic acetylcholine receptor in cerebellar cortex participates in acetylcholine-mediated blood depressor response in rats.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Cerebellar Cortex; Male; Microinjections; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Rats, Sprague-Dawley; Receptors, Muscarinic | 2015 |
Muscarinic modulation of TREK currents in mouse sympathetic superior cervical ganglion neurons.
Topics: Animals; Cells, Cultured; Cesium; Chlorides; Cholinergic Agents; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Male; Mice; Neurons; Oxotremorine; Patch-Clamp Techniques; Pertussis Toxin; Potassium Channel Blockers; Potassium Channels, Tandem Pore Domain; Receptors, Muscarinic; Riluzole; Sodium Channel Blockers; Superior Cervical Ganglion; Tetraethylammonium; Tetrodotoxin | 2015 |
Muscarinic receptor-mediated excitation of rat intracardiac ganglion neurons.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cells, Cultured; Ganglia, Parasympathetic; Membrane Potentials; Muscarinic Agonists; Neurons; Oxotremorine; Patch-Clamp Techniques; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Sodium; Type C Phospholipases | 2015 |
Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants.
Topics: Animals; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Cerebral Cortex; Depressive Disorder, Major; Disease Models, Animal; Female; Fluoxetine; Humans; Imipramine; Male; Middle Aged; Muscarinic Agonists; Oxotremorine; Pirenzepine; Radiopharmaceuticals; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Tritium | 2016 |
Electrophysiological evidence showing muscarinic agonist-antagonist activities of N-desmethylclozapine using hippocampal excitatory and inhibitory neurons.
Topics: Animals; Antipsychotic Agents; Clozapine; Hippocampus; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Oxotremorine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1 | 2016 |
A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockade by Oxotremorine-M.
Topics: Animals; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Oxotremorine; Potassium Channel Blockers; Pyridines; Receptor, Muscarinic M1; Thiadiazoles; Xenopus | 2016 |
Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release.
Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Corpus Striatum; Dopamine; Lipoprotein Lipase; Mice, Knockout; Muscarinic Agonists; Oxotremorine; Prepulse Inhibition; Pyridazines; Receptor, Cannabinoid, CB2; Receptor, Muscarinic M4; Thiophenes | 2016 |
Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures.
Topics: Animals; Fibroblast Growth Factor 2; Hippocampus; Male; Neuronal Outgrowth; Neuronal Plasticity; Neurons; Oxotremorine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Muscarinic M1; Receptors, Fibroblast Growth Factor; Receptors, G-Protein-Coupled; Receptors, Muscarinic; Signal Transduction | 2017 |
Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.
Topics: Acetylcholine; Animals; CSK Tyrosine-Protein Kinase; Female; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Interneurons; Male; Mice, Transgenic; Muscarinic Agonists; Nerve Tissue Proteins; Oxotremorine; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Potassium Channels, Tandem Pore Domain; Receptors, Muscarinic; Signal Transduction; src-Family Kinases; Thalamus; Up-Regulation | 2017 |
Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms.
Topics: Animals; Humans; Muscarinic Agonists; Oxotremorine; Phosphorylation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Xenopus | 2018 |
Heat shock protein (Hsp) regulation by muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus.
Topics: Animals; Heat Shock Transcription Factors; Heat-Shock Proteins; Hippocampus; Male; Neurodegenerative Diseases; Neuronal Outgrowth; Neuronal Plasticity; Neurons; Oxotremorine; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; Receptors, Muscarinic; Scopolamine; Signal Transduction | 2018 |
cPLA2α-/- sympathetic neurons exhibit increased membrane excitability and loss of N-Type Ca2+ current inhibition by M1 muscarinic receptor signaling.
Topics: Animals; Calcium; Calcium Channels, N-Type; Calcium Signaling; Group IV Phospholipases A2; Membrane Potentials; Neurons; Oxotremorine; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Muscarinic M1; Sympathetic Nervous System | 2018 |
Muscarinic modulation of M and h currents in gerbil spherical bushy cells.
Topics: Animals; Carbachol; Cholinergic Fibers; Cochlear Nucleus; Gerbillinae; Membrane Potentials; Muscarinic Agonists; Oxotremorine; Patch-Clamp Techniques; Receptors, Muscarinic | 2020 |
SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Glucose Intolerance; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteonectin; Oxotremorine; Phosphatidylinositol 3-Kinases; Receptor, Muscarinic M3; RGS Proteins | 2020 |
Identification of putative muscarinic acetylcholine receptor genes in Bactrocera dorsalis and functional analysis of Bdor-mAChR-B.
Topics: Acetylcholine; Animals; Base Sequence; Insect Proteins; Male; Muscarinic Agonists; Oxotremorine; Phylogeny; Receptors, Muscarinic; Sequence Alignment; Tephritidae | 2021 |