oxosorbicillinol has been researched along with bisvertinolone* in 2 studies
2 other study(ies) available for oxosorbicillinol and bisvertinolone
| Article | Year |
|---|---|
The same but different: multiple functions of the fungal flavin dependent monooxygenase SorD from Penicillium chrysogenum.
Sorbicillinoids are a large family of fungal secondary metabolites with a diverse range of structures and numerous bioactivites, some of which have pharmaceutical potential. The flavin-dependent monooxygenase SorD from Penicillium chrysogenum (PcSorD) utilizes sorbicillinol to catalyze a broad scope of reactions: formation of oxosorbicillinol and epoxysorbicillinol; intermolecular Diels-Alder and Michael-addition dimerization reactions; and dimerization of a sorbicillinol derivative with oxosorbicillinol. PcSorD shares only 18.3% sequence identity with SorD from Trichoderma reesei (TrSorD) and yet unexpectedly catalyzes many of the same reactions, however, the formation of oxosorbicillinol and bisvertinolone by PcSorD extends the range of reactions catalyzed by a single enzyme. Phylogenetic analysis indicates that PcSorD and TrSorD bind the flavin cofactor covalently but via different residues and point mutations confirm these residues are essential for activity. Topics: Alkenes; Cyclohexanones; Fungal Proteins; Hypocreales; Mixed Function Oxygenases; Mutation; Penicillium chrysogenum | 2020 |
The biosynthesis of bisvertinolone: evidence for oxosorbicillinol as a direct precursor.
Biosynthetic incorporation of labeled sodium acetate into oxosorbicillinol in Trichoderma sp. USF-2690 suggests that oxosorbicillinol is derived from six acetate units, and subsequent bioconversion of the labeled oxosorbicillinol to bisvertinolone in the fermentation of the strain suggests that bisvertinolone is biosynthesized from oxosorbicillinol and sorbicillinol in a Michael-type reaction. Topics: Alkenes; Chromatography, High Pressure Liquid; Cyclohexanones; Magnetic Resonance Spectroscopy; Molecular Structure; Trichoderma | 2002 |