oxepins and oxybutynin

oxepins has been researched along with oxybutynin* in 1 studies

Other Studies

1 other study(ies) available for oxepins and oxybutynin

Article	Year
1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists. Bioorganic & medicinal chemistry letters, 2007, Feb-15, Volume: 17, Issue:4 The structure-activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M(1)-M(3) receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M(3) receptor and potent effect on rhythmic increase in bladder pressure in unanesthetized rats following oral administration. These compounds displayed selectivity for the bladder over the salivary gland. Topics: Animals; Binding, Competitive; Cell Line; Humans; Indicators and Reagents; Insecta; Mandelic Acids; Muscarinic Antagonists; Oxepins; Rats; Receptor, Muscarinic M3; Salivary Glands; Scopolamine; Structure-Activity Relationship; Urinary Bladder, Neurogenic	2007

Article

Year

1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists.

Bioorganic & medicinal chemistry letters, 2007, Feb-15, Volume: 17, Issue:4

The structure-activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M(1)-M(3) receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M(3) receptor and potent effect on rhythmic increase in bladder pressure in unanesthetized rats following oral administration. These compounds displayed selectivity for the bladder over the salivary gland.

Topics: Animals; Binding, Competitive; Cell Line; Humans; Indicators and Reagents; Insecta; Mandelic Acids; Muscarinic Antagonists; Oxepins; Rats; Receptor, Muscarinic M3; Salivary Glands; Scopolamine; Structure-Activity Relationship; Urinary Bladder, Neurogenic

2007