oxcarbazepine has been researched along with 10-hydroxycarbamazepine in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (9.88) | 18.7374 |
| 1990's | 18 (22.22) | 18.2507 |
| 2000's | 30 (37.04) | 29.6817 |
| 2010's | 24 (29.63) | 24.3611 |
| 2020's | 1 (1.23) | 2.80 |
| Authors | Studies |
|---|---|
| Alves, PC; Benes, J; Cunha, RA; Figueiredo, AA; Freitas, AP; Garrett, J; Learmonth, DA; Parada, A; Soares-da-Silva, P | 1 |
| Czendlik, C; Flesch, G; Lloyd, P; Renard, D | 1 |
| Abdelrahman, A; Dosa, S; El-Tayeb, A; Hinz, S; Müller, CE; Tian, M; Weinhausen, S; Weyer, S | 1 |
| Boas, J; Dam, M; Flesch, G; Jensen, PK; Jórgensen, L; Mogensen, PH; Vesterager, A | 1 |
| Forsythe, WI; Green, M; Hartley, R; Lucock, MD; Ryan, S | 1 |
| Elyas, AA; Patsalos, PN; Zakrzewska, JM | 1 |
| Elyas, AA; Goldberg, VD; Patsalos, PN | 1 |
| Dickinson, RG; Dunstan, PR; Eadie, MJ; Hooper, WD | 1 |
| Bittencourt, PR; Silvado, CE | 1 |
| Paar, WD; von Unruh, GE | 2 |
| Bülau, P; Paar, WD; von Unruh, GE | 1 |
| Kumps, A; Mardens, Y | 1 |
| Farago, F | 1 |
| Jönsson, B; Klitgaard, NA; Kristensen, O; Sindrup, S | 1 |
| Bernardi, G; Calabresi, P; De Murtas, M; Mercuri, NB; Pisani, A; Sancesario, G; Stefani, A | 1 |
| Calabresi, P; De Murtas, M; Marciani, MG; Mercuri, NB; Pisani, A; Stefani, A | 1 |
| Feldmann, KF; McLean, MJ; Portet, C; Schmutz, M; Wamil, AW | 1 |
| Artesi, C; Di Perri, R; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Xiao, B | 1 |
| Meinardi, H; Van Parys, JA | 1 |
| De koster, V; Ebinger, G; Michotte, Y; Sarre, S; Van Belle, K | 1 |
| Brugger, F; Gentsch, C; McLean, MJ; Olpe, HR; Schmutz, M | 1 |
| Schwabe, S | 1 |
| al-Hassan, MI; Matar, KM; Nicholls, PJ; Tekle, A | 1 |
| Ebinger, G; Michotte, Y; Van Belle, K; Verfaillie, I | 1 |
| Frey, HH; Schicht, S; Wigger, D | 1 |
| Bialer, M; Perucca, E; Sintov, A; Volosov, A; Xiaodong, S; Yagen, B | 1 |
| Abou-Khalil, B; Bettis, D; D'Souza, J; Frank, LM; Geoffroy, G; Glauser, TA; Grinspan, A; Guarino, T; Jacobs, T; Kerrigan, J; Kramer, L; Mandelbaum, D; Mesenbrink, P; Nigro, M; Pasteris, LA; Sachdeo, R; Weinstein, S | 1 |
| Bialer, M; Volosov, A; Yagen, B | 1 |
| Ichikawa, K; Kiguchi, S; Kojima, M | 1 |
| Balslev, T; Christensen, J; Dam, M; Heinsvig, EM; Poulsen, JH; Villadsen, J | 1 |
| Christensen, J; Dam, M; Højskov, CS; Poulsen, JH | 1 |
| Jouppila, P; Myllynen, P; Pienimäki, P; Vähäkangas, K | 1 |
| Kraemer, T; Kratzsch, C; Maurer, HH; Peters, FT; Weber, AA | 1 |
| Bossu, H; Gagnieu, MC; Lardet, G; Moulsma, M; Parant, F | 1 |
| D'Souza, J; Flesch, G; Hossain, M; Souppart, C; Tudor, D | 1 |
| Bonner, J; Camisasca, R; Denouel, J; Flesch, G; Tudor, D | 1 |
| Bartoli, A; Galimberti, CA; Gatti, G; Limido, G; Manni, R; Morini, R; Perucca, E; Strada, G; Tartara, A | 1 |
| Baumann, RJ; DeGrauw, TJ; Fakhoury, TA; Grim, SA; Miles, MV; Ryan, MA; Strawsburg, RH; Tang, PH | 1 |
| Almeida, L; Soares-da-Silva, P | 1 |
| Fowler, DR; Green-Johnson, D; Levine, B; Moore, KA | 1 |
| Adín, J; Armijo, JA; Herranz, JL; Shushtarian, M; Vega-Gil, N | 1 |
| Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I | 1 |
| Albani, F; Balboni, M; Baruzzi, A; Callegati, E; Candela, C; Contin, M; Riva, R | 1 |
| Baumgartner, C; Caccia, S; Czech, T; Guiso, G; Janigro, D; Marchi, N; Novak, K; Pirker, S; Rizzi, M; Vezzani, A | 1 |
| Clinckers, R; Lanckmans, K; Michotte, Y; Sarre, S; Smolders, I; Van Eeckhaut, A | 1 |
| Bilo, L; Di Nocera, P; Fasiello, C; Italiano, D; Pisani, F; Ruosi, P; Striano, P; Striano, S | 1 |
| Franceschi, L; Furlanut, M; Pecorari, M; Poz, D; Silvestri, L | 1 |
| Ajjala, DR; Kandikere, VN; Mudigonda, K; Nirogi, RV; Shukla, M | 1 |
| Lanckmans, K; Michotte, Y; Sarre, S; Smolders, I; Van Eeckhaut, A | 1 |
| Christensen, J; Sabers, A; Sidenius, P | 1 |
| Fattore, C; Franco, V; Gatti, G; Marchiselli, R; Mazzucchelli, I; Perucca, E | 1 |
| Alves, G; Caramona, M; Castel-Branco, M; Falcão, A; Figueiredo, I; Loureiro, A | 1 |
| Di Girolamo, G; Gonzalez, CD; Moncalvo, JJ; Opezzo, JA; Schere, D | 1 |
| Giannoutsos, S; Greiner-Sosanko, E; Krasowski, MD; Lower, DR; Virji, MA | 1 |
| Hansen, SH; Linnet, K; Sabers, A; Simonsen, KW; Steentoft, A | 1 |
| Alves, G; Caramona, M; Castel-Branco, M; Falcão, A; Figueiredo, I; Soares-Da-Silva, P | 1 |
| Clinckers, R; Danhof, M; Della Pasqua, O; Ebinger, G; Michotte, Y; Smolders, I; Voskuyl, RA | 1 |
| Alves, G; Falcão, A; Fortuna, A; Soares-da-Silva, P; Sousa, J | 1 |
| Bhatt, M; Shah, S | 1 |
| de Haan, GJ; Edelbroek, P; Lindhout, D; Sander, JW; Wegner, I | 1 |
| Almeida, L; Elger, C; Falcão, A; Halász, P; Perucca, E; Soares-da-Silva, P | 1 |
| Almeida, A; Alves, G; Falcão, A; Fortuna, A; Lopes, B; Soares-da-Silva, P | 1 |
| Fernandes-Lopes, C; Loureiro, AI; Soares-da-Silva, P; Wright, LC | 1 |
| Fahie, K; Fowler, D; Levine, B; Naso, C; Phipps, RJ | 1 |
| Almeida, L; Falcão, A; Nunes, T; Rocha, JF; Soares-da-Silva, P | 1 |
| Alexandre, V; Coelho, EB; de Jesus Antunes, N; Della Pasqua, O; Lanchote, VL; Takayanagui, OM; Tozatto, E; Wichert-Ana, L | 1 |
| Bocato, MZ; Bortoleto, MA; de Oliveira, AR; Pupo, MT | 1 |
| Angier, MK; Johnson, RD; Lewis, RJ | 1 |
| Alves, G; Falcão, A; Ferreira, A; Fortuna, A; Francisco, J; Oliveira, P; Rodrigues, M; Rosado, L; Rosado, P | 1 |
| Cai, JP; Chen, M; Chen, X; Gu, E; Hu, G; Wang, L; Wang, S; Zheng, X; Zhou, H | 1 |
| Alexandre Junior, V; Antunes, Nde J; Coelho, EB; Della Pasqua, O; Lanchote, VL; Marques, MP; Takayanagui, OM; Tozatto, E; Wichert-Ana, L | 1 |
| Cai, LX; Chen, CY; Cui, YM; Li, RR; Ma, LY; Sheng, XY; Wu, Y; Yao, HX; Zhou, Y; Zhu, SN | 1 |
| Fawcett, JP; Gu, J; Sun, L; Wang, H; Xu, X; Yang, Y; Yang, Z; Zhao, X | 1 |
| Crommen, J; Fillet, M; Janicot, B; Servais, AC; Takam, A | 1 |
| Alexandre Junior, V; Antunes, NJ; Coelho, EB; Della Pasqua, O; Lanchote, VL; Takayanagui, OM; Tozatto, E; van Dijkman, SC; van Hasselt, JGC; Wichert-Ana, L | 1 |
| Alexandre Junior, V; Antunes, NJ; Coelho, EB; Della Pasqua, O; Lanchote, VL; Marques, MP; Takayanagui, OM; Wichert-Ana, L | 1 |
| Cui, J; Du, L; Niu, Y; Ou, Z; Tang, L; Xu, J | 1 |
| Chen, X; Fang, S; Gong, Z; Ma, H; Qian, L; Wei, J; Xu, Z; Yan, Y; Yang, X; Zeng, S | 1 |
| Hao, Z; Liu, C; Pan, L; Qu, L; Tian, Y; Wang, L | 1 |
| Bak, LK; Jakobsen, E; Krarup, S; Lindholm, SEH; Mertz, C; Pinborg, LH | 1 |
1 review(s) available for oxcarbazepine and 10-hydroxycarbamazepine
| Article | Year |
|---|---|
Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma.
Topics: Animals; Carbamazepine; Chromatography, Supercritical Fluid; Dibenzazepines; Dogs; Limit of Detection; Linear Models; Oxcarbazepine; Reproducibility of Results; Tandem Mass Spectrometry | 2016 |
17 trial(s) available for oxcarbazepine and 10-hydroxycarbamazepine
| Article | Year |
|---|---|
Pharmacokinetics of the monohydroxy derivative of oxcarbazepine and its enantiomers after a single intravenous dose given as racemate compared with a single oral dose of oxcarbazepine.
Topics: Administration, Oral; Adult; Anticonvulsants; Biological Availability; Carbamazepine; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Molecular Structure; Reproducibility of Results; Stereoisomerism; Tissue Distribution | 2011 |
Oxcarbazepine, GP 47779, and spasticity.
Topics: Adult; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsy, Temporal Lobe; Humans; Muscle Spasticity; Oxcarbazepine | 1985 |
Gas chromatographic/mass spectrometric assays for oxcarbazepine and its main metabolites, 10-hydroxy-carbazepine and carbazepine-10,11-trans-diol.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Clinical Trials as Topic; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Oxcarbazepine | 1986 |
Trigeminal neuralgia: its treatment with two new carbamazepine analogues.
Topics: Adult; Aged; Aged, 80 and over; Carbamazepine; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Oxcarbazepine; Trigeminal Neuralgia | 1987 |
Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Cross-Over Studies; Depressive Disorder; Double-Blind Method; Epilepsies, Partial; Epilepsy; Epilepsy, Complex Partial; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Oxcarbazepine; Viloxazine | 1994 |
Adjunctive therapy with oxcarbazepine in children with partial seizures. The Oxcarbazepine Pediatric Study Group.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Double-Blind Method; Electroencephalography; Epilepsies, Partial; Female; Humans; Male; Oxcarbazepine; Regression Analysis; Treatment Outcome | 2000 |
Oxcarbazepine final market image tablet formulation bioequivalence study after single administration and at steady state in healthy subjects.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Carbamazepine; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Dibenzazepines; Fasting; Food-Drug Interactions; Half-Life; Humans; Male; Middle Aged; Oxcarbazepine; Tablets; Therapeutic Equivalency | 2002 |
Assessment of the bioequivalence of two oxcarbazepine oral suspensions versus a film-coated tablet in healthy subjects.
Topics: Adult; Anticonvulsants; Area Under Curve; Carbamazepine; Cross-Over Studies; Dibenzazepines; Half-Life; Humans; Male; Oxcarbazepine; Suspensions; Therapeutic Equivalency | 2003 |
The pharmacokinetics of oxcarbazepine and its active metabolite 10-hydroxy-carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Female; Half-Life; Humans; Male; Oxcarbazepine; Phenobarbital; Valproic Acid | 1993 |
Safety, tolerability, and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic, in a rising multiple-dose study in young healthy humans.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Carbamazepine; Dibenzazepines; Dose-Response Relationship, Drug; Double-Blind Method; Half-Life; Humans; Male; Middle Aged; Oxcarbazepine; Tablets | 2004 |
Quantification of oxcarbazeipine and its active metabolite 10-hydroxycarbazepine in human plasma by high-performance liquid chromatography.
Topics: Anticonvulsants; Calibration; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Oxcarbazepine; Reproducibility of Results; Spectrophotometry, Ultraviolet; Therapeutic Equivalency | 2006 |
Parent drug and/or metabolite? Which of them is most appropriate to establish bioequivalence of two oral oxcarbazepine formulations in healthy volunteers?
Topics: Administration, Oral; Adult; Anticonvulsants; Area Under Curve; Biotransformation; Calibration; Carbamazepine; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Half-Life; Humans; Linear Models; Male; Metabolic Clearance Rate; Models, Biological; Oxcarbazepine; Reference Values; Reproducibility of Results; Research Design; Therapeutic Equivalency | 2007 |
Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures.
Topics: Adult; Anticonvulsants; Carbamazepine; Dibenzazepines; Dose-Response Relationship, Drug; Female; Humans; International Cooperation; Male; Middle Aged; Oxcarbazepine; Seizures; Tandem Mass Spectrometry; Time Factors; Young Adult | 2011 |
Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Dibenzazepines; Female; Humans; Male; Middle Aged | 2013 |
Influence of verapamil on the pharmacokinetics of oxcarbazepine and of the enantiomers of its 10-hydroxy metabolite in healthy volunteers.
Topics: Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamazepine; Cross-Over Studies; Female; Healthy Volunteers; Humans; Male; Oxcarbazepine; Stereoisomerism; Verapamil; Young Adult | 2016 |
Saliva and Plasma Monohydroxycarbamazepine Concentrations in Pediatric Patients With Epilepsy.
Topics: Adolescent; Anticonvulsants; Asian People; Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Monitoring; Epilepsy; Female; Humans; Infant; Linear Models; Male; Oxcarbazepine; Prospective Studies; Saliva | 2016 |
Population pharmacokinetics of oxcarbazepine and its metabolite 10-hydroxycarbazepine in healthy subjects.
Topics: Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Carbamazepine; Cross-Over Studies; Female; Healthy Volunteers; Humans; Male; Oxcarbazepine; Seizures; Stereoisomerism; Verapamil; Young Adult | 2017 |
63 other study(ies) available for oxcarbazepine and 10-hydroxycarbamazepine
| Article | Year |
|---|---|
Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.
Topics: Amides; Animals; Anticonvulsants; Azepines; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Electroshock; In Vitro Techniques; Ion Channel Gating; Motor Activity; Prodrugs; Rats; Seizures; Sodium; Stereoisomerism; Structure-Activity Relationship; Synaptosomes | 1999 |
Carbamazepine derivatives with P2X4 receptor-blocking activity.
Topics: Adenosine Triphosphate; Animals; Calcium; Carbamazepine; Chemistry Techniques, Synthetic; Dibenzazepines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Mice; Purinergic P2X Receptor Antagonists; Rats; Receptors, Purinergic P2X4; Structure-Activity Relationship | 2014 |
Effects of dextropropoxyphene on the steady-state kinetics of oxcarbazepine and its metabolites.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Oxcarbazepine; Trigeminal Neuralgia | 1992 |
Solid phase extraction of oxcarbazepine and its metabolites from plasma for analysis by high performance liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Oxcarbazepine | 1991 |
Protein binding of oxcarbazepine and its primary active metabolite, 10-hydroxycarbazepine, in patients with trigeminal neuralgia.
Topics: Adult; Aged; Blood Proteins; Carbamazepine; Female; Humans; Male; Middle Aged; Oxcarbazepine; Protein Binding; Trigeminal Neuralgia | 1990 |
Simple and rapid micro-analytical high-performance liquid chromatographic technique for the assay of oxcarbazepine and its primary active metabolite 10-hydroxycarbazepine.
Topics: Autoanalysis; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Microchemistry; Oxcarbazepine | 1990 |
First dose and steady-state pharmacokinetics of oxcarbazepine and its 10-hydroxy metabolite.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Male; Oxcarbazepine | 1989 |
Pharmacokinetics of oxcarbazepine and 10-hydroxy-carbazepine in the newborn child of an oxcarbazepine-treated mother.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Fetal Blood; Half-Life; Humans; Infant, Newborn; Milk, Human; Oxcarbazepine | 1988 |
Cross-reactivity assessment of oxcarbazepine and its metabolites in the EMIT assay of carbamazepine plasma levels.
Topics: Biotransformation; Carbamazepine; Cross Reactions; Humans; Immunoenzyme Techniques; Oxcarbazepine | 1986 |
Gas chromatographic assay for oxcarbazepine and its main metabolites in plasma.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Drug Stability; Humans; Oxcarbazepine | 1985 |
Pharmacokinetics of 10-OH-carbazepine, the main metabolite of the antiepileptic oxcarbazepine, from serum and saliva concentrations.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Oxcarbazepine; Protein Binding; Saliva | 1983 |
Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission.
Topics: Adenosine; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Corpus Striatum; Evoked Potentials; Excitatory Amino Acids; Glutamic Acid; Male; Neural Pathways; Oxcarbazepine; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Presynaptic; Receptors, Purinergic P1; Synaptic Transmission | 1995 |
Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. II. Modulation of high-voltage-activated calcium currents.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Cell Separation; Cerebral Cortex; Corpus Striatum; Dihydropyridines; Glutamates; Male; Neural Pathways; Nifedipine; Oxcarbazepine; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Presynaptic; Synaptic Transmission | 1995 |
Effects of oxcarbazepine and 10-hydroxycarbamazepine on action potential firing and generalized seizures.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Cells, Cultured; Male; Mice; Oxcarbazepine; Rats; Seizures; Sodium; Spinal Cord | 1994 |
Survey of 260 epileptic patients treated with oxcarbazepine (Trileptal) on a named-patient basis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Male; Middle Aged; Netherlands; Oxcarbazepine; Product Surveillance, Postmarketing; Treatment Outcome | 1994 |
Narrow-bore liquid chromatographic assay for oxcarbazepine and its major metabolite in rat brain, liver and blood microdialysates.
Topics: Animals; Anticonvulsants; Brain Chemistry; Carbamazepine; Chromatography, Liquid; Dialysis; Liver; Male; Oxcarbazepine; Quality Control; Rats; Rats, Wistar; Sensitivity and Specificity | 1994 |
Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Evaluation, Preclinical; Electroshock; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Mice; Oxcarbazepine; Pentylenetetrazole; Potassium Channels; Rats; Receptors, Neurotransmitter; Seizures; Sodium Channels | 1994 |
Oxcarbazepine: clinical development program.
Topics: Aged; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Drug Administration Schedule; Drug Approval; Drugs, Investigational; Enzyme Induction; Epilepsy; Humans; Liver; Oxcarbazepine; United States; United States Food and Drug Administration | 1994 |
Rapid micromethod for simultaneous measurement of oxcarbazepine and its active metabolite in plasma by high-performance liquid chromatography.
Topics: Animals; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Stability; Humans; Male; Microchemistry; Oxcarbazepine; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 1995 |
Liquid chromatographic assay using a microcolumn coupled to a U-shaped optical cell for high-sensitivity ultraviolet absorbance detection of oxcarbazepine and its major metabolite in microdialysates.
Topics: Animals; Anticonvulsants; Carbamazepine; Chromatography, Liquid; Dialysis Solutions; Hippocampus; Male; Microdialysis; Oxcarbazepine; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1995 |
Pharmacokinetics of oxcarbazepine in the dog.
Topics: Administration, Oral; Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Dogs; Epilepsy; Female; Half-Life; Jejunum; Male; Oxcarbazepine; Protein Binding; Statistics as Topic | 1996 |
Enantioselective pharmacokinetics of 10-hydroxycarbazepine after oral administration of oxcarbazepine to healthy Chinese subjects.
Topics: Administration, Oral; Adult; Anticonvulsants; Asian People; Carbamazepine; China; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Oxcarbazepine; Reference Values; Stereoisomerism | 1999 |
Comparative stereoselective pharmacokinetic analysis of 10-hydroxycarbazepine after oral administration of its individual enantiomers and the racemic mixture to dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Carbamazepine; Cross-Over Studies; Dogs; Drug Design; Epilepsy; Glucuronides; Humans; Oxcarbazepine; Stereoisomerism | 2000 |
Suppressive effects of oxcarbazepine on tooth pulp-evoked potentials recorded at the trigeminal spinal tract nucleus in cats.
Topics: Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Carbamazepine; Cats; Dental Pulp; Dibenzazepines; Electric Stimulation; Evoked Potentials; Female; Male; Mexiletine; Microinjections; Morphine; Oxcarbazepine; Polyethylene Glycols; Synaptic Transmission; Trigeminal Nucleus, Spinal | 2001 |
Removal of 10-hydroxycarbazepine by plasmapheresis.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Electroencephalography; Encephalitis; Humans; Male; Oxcarbazepine; Plasmapheresis; Treatment Outcome | 2001 |
Plasma concentration of topiramate correlates with cerebrospinal fluid concentration.
Topics: Adolescent; Adult; Anticonvulsants; Blood-Brain Barrier; Brain; Carbamazepine; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Lamotrigine; Male; Middle Aged; Oxcarbazepine; Prospective Studies; Topiramate; Triazines | 2001 |
Transplacental passage of oxcarbazepine and its metabolites in vivo.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Blood; Humans; Maternal-Fetal Exchange; Oxcarbazepine; Placenta; Pregnancy; Pregnancy Complications | 2001 |
Validated assay for quantification of oxcarbazepine and its active dihydro metabolite 10-hydroxycarbazepine in plasma by atmospheric pressure chemical ionization liquid chromatography/mass spectrometry.
Topics: Anticonvulsants; Calibration; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Mass Spectrometry; Oxcarbazepine; Reference Standards; Reproducibility of Results | 2002 |
Cross-reactivity assessment of carbamazepine-10,11-epoxide, oxcarbazepine, and 10-hydroxy-carbazepine in two automated carbamazepine immunoassays: PETINIA and EMIT 2000.
Topics: Adult; Carbamazepine; Chromatography, High Pressure Liquid; Cross Reactions; Enzyme Multiplied Immunoassay Technique; Female; Fluorescence Polarization Immunoassay; Humans; Immunoassay; Linear Models; Male; Middle Aged; Nephelometry and Turbidimetry; Oxcarbazepine | 2003 |
Feasibility and limitations of oxcarbazepine monitoring using salivary monohydroxycarbamazepine (MHD).
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Monitoring; Epilepsy; Feasibility Studies; Female; Humans; Male; Middle Aged; Oxcarbazepine; Saliva | 2004 |
Hydroxycarbazepine distribution in three postmortem cases.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Humans; Kidney; Liver; Myocardium; Oxcarbazepine; Suicide; Tissue Distribution | 2004 |
10-Hydroxycarbazepine serum concentration-to-oxcarbazepine dose ratio: influence of age and concomitant antiepileptic drugs.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Chromatography, Liquid; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Enzyme Induction; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Multivariate Analysis; Outpatients; Retrospective Studies; Time Factors | 2005 |
Hippocampal dopamine and serotonin elevations as pharmacodynamic markers for the anticonvulsant efficacy of oxcarbazepine and 10,11-dihydro-10-hydroxycarbamazepine.
Topics: Animals; Anticonvulsants; Biomarkers; Carbamazepine; Dopamine; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; Kinetics; Male; Metabolic Clearance Rate; Microdialysis; Pharmacokinetics; Rats; Rats, Wistar; Serotonin; Treatment Outcome | 2005 |
Simultaneous liquid chromatographic determination of lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Dibenzazepines; Drug Monitoring; Epilepsy; Felbamate; Humans; Lamotrigine; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Spectrophotometry, Ultraviolet; Triazines | 2005 |
A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine.
Topics: Adult; Aged; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbamazepine; Child; Drug Resistance; Drug Resistance, Multiple; Epilepsy; Female; Humans; In Vitro Techniques; Male; Oxcarbazepine; Pilot Projects; RNA, Messenger | 2005 |
Use of microbore LC-MS/MS for the quantification of oxcarbazepine and its active metabolite in rat brain microdialysis samples.
Topics: Animals; Brain Chemistry; Carbamazepine; Chromatography, Liquid; Hippocampus; Male; Mass Spectrometry; Microdialysis; Oxcarbazepine; Rats; Rats, Wistar; Reproducibility of Results | 2006 |
Relationship between serum mono-hydroxy-carbazepine concentrations and adverse effects in patients with epilepsy on high-dose oxcarbazepine therapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle Aged; Oxcarbazepine | 2006 |
Acute oxcarbazepine, benazepril, and hydrochlorothiazide overdose with alcohol.
Topics: Anticonvulsants; Antihypertensive Agents; Benzazepines; Carbamazepine; Critical Care; Diuretics; Drug Overdose; Humans; Hydrochlorothiazide; Male; Middle Aged; Oxcarbazepine; Recovery of Function; Renal Dialysis; Tablets; Time Factors; Wine | 2006 |
Capillary and nano-liquid chromatography-tandem mass spectrometry for the quantification of small molecules in microdialysis samples: comparison with microbore dimensions.
Topics: Calibration; Carbamazepine; Chromatography, Liquid; Dialysis Solutions; Microdialysis; Nanotechnology; Oxcarbazepine; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2006 |
Oxcarbazepine concentrations during pregnancy: a retrospective study in patients with epilepsy.
Topics: Analysis of Variance; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Osmolar Concentration; Oxcarbazepine; Postpartum Period; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Retrospective Studies | 2006 |
A novel enantioselective microassay for the high-performance liquid chromatography determination of oxcarbazepine and its active metabolite monohydroxycarbazepine in human plasma.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Dibenzazepines; Drug Monitoring; Humans; Oxcarbazepine | 2007 |
Simultaneous and enantioselective liquid chromatographic determination of eslicarbazepine acetate, S-licarbazepine, R-licarbazepine and oxcarbazepine in mouse tissue samples using ultraviolet detection.
Topics: Animals; Calibration; Carbamazepine; Chromatography, Liquid; Dibenzazepines; Mice; Mice, Inbred Strains; Oxcarbazepine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism; Tissue Distribution | 2007 |
Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetam.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nitrogen; Oxcarbazepine; Phosphorus; Piracetam; Reproducibility of Results; Triazines; Ultraviolet Rays; Zonisamide | 2007 |
An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Forensic Toxicology; Gastrointestinal Contents; Humans; Liver; Male; Middle Aged; Muscle, Skeletal; Oxcarbazepine; Vitreous Body | 2008 |
Stereoselective disposition of S- and R-licarbazepine in mice.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Carbamazepine; Chromatography, High Pressure Liquid; Dibenzazepines; Kidney; Liver; Male; Mice; Models, Biological; Oxcarbazepine; Stereoisomerism; Tissue Distribution | 2008 |
Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain.
Topics: Animals; Anticonvulsants; Biological Transport; Carbamazepine; Chromatography, Liquid; Dose-Response Relationship, Drug; Hippocampus; Male; Microdialysis; Models, Biological; Nonlinear Dynamics; Rats; Rats, Wistar; Seizures; Tissue Distribution | 2008 |
Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Dibenzazepines; Humans; Molecular Structure; Oxcarbazepine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 2010 |
Rapid ultraperformance liquid chromatography-tandem mass spectrometry method for quantification of oxcarbazepine and its metabolite in human plasma.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Drug Stability; Humans; Least-Squares Analysis; Oxcarbazepine; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Time Factors | 2011 |
Drug monitoring of lamotrigine and oxcarbazepine combination during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Lamotrigine; Metabolic Clearance Rate; Oxcarbazepine; Postpartum Period; Pregnancy; Pregnancy Complications; Triazines | 2010 |
A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain.
Topics: Animals; Anticonvulsants; Brain; Calibration; Carbamazepine; Chromatography, Liquid; Dibenzazepines; Mice; Oxcarbazepine; Quality Control; Reference Standards; Spectrophotometry, Ultraviolet; Stereoisomerism | 2012 |
Development and validation of an enantioselective liquid-chromatography/tandem mass spectrometry method for the separation and quantification of eslicarbazepine acetate, eslicarbazepine, R-licarbazepine and oxcarbazepine in human plasma.
Topics: Carbamazepine; Chromatography, Liquid; Dibenzazepines; Drug Stability; Humans; Male; Oxcarbazepine; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry | 2011 |
Tissue distribution of newer anticonvulsant drugs in postmortem cases.
Topics: Adult; Anticonvulsants; Autopsy; Carbamazepine; Chromatography, Gas; Fatal Outcome; Female; Fructose; Humans; Kidney; Levetiracetam; Liver; Male; Middle Aged; Oxcarbazepine; Piracetam; Tissue Distribution; Topiramate; Young Adult | 2010 |
Analysis of oxcarbazepine and the 10-hydroxycarbazepine enantiomers in plasma by LC-MS/MS: application in a pharmacokinetic study.
Topics: Administration, Oral; Blood Chemical Analysis; Carbamazepine; Chromatography, Liquid; Humans; Limit of Detection; Oxcarbazepine; Stereoisomerism; Tandem Mass Spectrometry | 2013 |
A new enantioselective CE method for determination of oxcarbazepine and licarbazepine after fungal biotransformation.
Topics: Biotransformation; Carbamazepine; Dibenzazepines; Electrophoresis, Capillary; Linear Models; Oxcarbazepine; Phyllachorales; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2014 |
False carbamazepine positives due to 10,11-dihydro-10-hydroxycarbamazepine breakdown in the GC-MS injector port.
Topics: Accidents, Aviation; Anticonvulsants; Autopsy; Calibration; Carbamazepine; False Positive Reactions; Forensic Pathology; Gas Chromatography-Mass Spectrometry; Humans; Oxcarbazepine; Specimen Handling | 2014 |
Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine.
Topics: Anticonvulsants; Carbamazepine; Chemical Fractionation; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dibenzazepines; Drug Monitoring; Epoxy Compounds; Humans; Lamotrigine; Oxcarbazepine; Phenobarbital; Phenytoin; Quality Control; Reproducibility of Results; Triazines | 2014 |
Evaluation of the Effects of Ketoconazole and Voriconazole on the Pharmacokinetics of Oxcarbazepine and Its Main Metabolite MHD in Rats by UPLC-MS-MS.
Topics: Animals; Anticonvulsants; Antifungal Agents; Biotransformation; Carbamazepine; Chromatography, High Pressure Liquid; Diazepam; Drug Combinations; Drug Interactions; Ketoconazole; Limit of Detection; Male; Oxcarbazepine; Prodrugs; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Voriconazole | 2016 |
Liquid chromatography separation of the chiral prodrug eslicarbazepine acetate and its main metabolites in polar organic mode. Application to their analysis after in vitro metabolism.
Topics: Acetic Acid; Acetonitriles; Carbamazepine; Cellulose; Chromatography, Liquid; Dibenzazepines; Diethylamines; Humans; Microsomes, Liver; Oxcarbazepine; Phenylcarbamates; Prodrugs; Solid Phase Extraction; Solvents; Stereoisomerism | 2016 |
Analysis of unbound plasma concentration of oxcarbazepine and the 10-hydroxycarbazepine enantiomers by liquid chromatography with tandem mass spectrometry in healthy volunteers.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Healthy Volunteers; Humans; Oxcarbazepine; Prodrugs; Reproducibility of Results; Stereoisomerism; Tandem Mass Spectrometry; Young Adult | 2018 |
Preparation of Interface-Assembled Carbonyl Reductase and Its Application in the Synthesis of S-Licarbazepine in Toluene/Tris-HCl Buffer Biphasic System.
Topics: Alcohol Oxidoreductases; Carbamazepine; Dibenzazepines; Ethanol; Hydrogen-Ion Concentration; Hydroxyapatites; NAD; Oxcarbazepine; Polystyrenes; Substrate Specificity; Temperature; Toluene; Tromethamine | 2018 |
Comparison of oxcarbazepine efficacy and MHD concentrations relative to age and BMI: Associations among ABCB1, ABCC2, UGT2B7, and SCN2A polymorphisms.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Asian People; ATP Binding Cassette Transporter, Subfamily B; Body Mass Index; Carbamazepine; Child; Child, Preschool; China; Epilepsy; Female; Genotype; Glucuronosyltransferase; Humans; Infant; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; NAV1.2 Voltage-Gated Sodium Channel; Oxcarbazepine; Polymorphism, Single Nucleotide; Young Adult | 2019 |
Development of an online solid-phase extraction-liquid chromatography-mass spectrometric analysis of oxcarbazepine and its active metabolite licarbazepine from plasma with a direct injection step.
Topics: Chromatography, High Pressure Liquid; Dibenzazepines; Humans; Oxcarbazepine; Solid Phase Extraction; Tandem Mass Spectrometry | 2019 |
Distinct effects on cAMP signaling of carbamazepine and its structural derivatives do not correlate with their clinical efficacy in epilepsy.
Topics: Adenylyl Cyclases; Anticonvulsants; Calcium Signaling; Carbamazepine; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dibenzazepines; Epilepsy; HEK293 Cells; Humans; Oxcarbazepine; Seizures; Signal Transduction; Treatment Outcome | 2020 |