oxazolidine and thiazomycin

oxazolidine has been researched along with thiazomycin* in 1 studies

Other Studies

1 other study(ies) available for oxazolidine and thiazomycin

Article	Year
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa. Bioorganic & medicinal chemistry, 2008, Oct-01, Volume: 16, Issue:19 Thiazolyl peptides are a class of thiazole-rich macrocyclic potent antibacterial agents. Recently, we described thiazomycin, a new member of thiazolyl peptides, discovered by a thiazolyl peptide specific chemical screening. This method also allowed for the discovery of a new thiazolyl peptide, thiazomycin A, which carries modification in the oxazolidine ring of the amino sugar moiety. Thiazomycin A is a specific inhibitor of protein synthesis (IC(50) 0.7 microg/mL) and a potent Gram-positive antibacterial agent with minimum inhibitory concentration (MIC) ranging 0.002-0.25 microg/mL. The isolation and structure elucidation and biological activities of thiazomycin A are described. Topics: Actinomycetales; Anti-Bacterial Agents; Inhibitory Concentration 50; Microbial Sensitivity Tests; Oxazoles; Peptides, Cyclic; Staphylococcus aureus; Thiazoles	2008

Article

Year

Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.

Bioorganic & medicinal chemistry, 2008, Oct-01, Volume: 16, Issue:19

Thiazolyl peptides are a class of thiazole-rich macrocyclic potent antibacterial agents. Recently, we described thiazomycin, a new member of thiazolyl peptides, discovered by a thiazolyl peptide specific chemical screening. This method also allowed for the discovery of a new thiazolyl peptide, thiazomycin A, which carries modification in the oxazolidine ring of the amino sugar moiety. Thiazomycin A is a specific inhibitor of protein synthesis (IC(50) 0.7 microg/mL) and a potent Gram-positive antibacterial agent with minimum inhibitory concentration (MIC) ranging 0.002-0.25 microg/mL. The isolation and structure elucidation and biological activities of thiazomycin A are described.

Topics: Actinomycetales; Anti-Bacterial Agents; Inhibitory Concentration 50; Microbial Sensitivity Tests; Oxazoles; Peptides, Cyclic; Staphylococcus aureus; Thiazoles

2008