oxazolidine has been researched along with mesoxalic-acid* in 1 studies
1 other study(ies) available for oxazolidine and mesoxalic-acid
| Article | Year |
|---|---|
Construction of 1,3-Oxazolidines through a Three-Component [3+2] Cycloaddition of Tetrahydroisoquinolines, Aldehydes, and Ethyl Ketomalonate.
A chemoselective and diastereoselective synthesis of fused oxazolidines was achieved by a three-component cascade reaction of tetrahydroisoquinolines (THIQs), α,β-unsaturated aldehydes, and diethyl 2-oxomalonate. Probably due to the reactivity difference between the aldehyde and the ketone, the reaction proceeded through the condensation of THIQs with α,β-unsaturated aldehydes and 1,3-dipolar cycloaddition of the generated azomethine ylide intermediate with 2-oxomalonate. The key features are easily available starting materials, mild reaction conditions, broad substrate scope, and high chemo- and diastereoselectivity. Topics: Aldehydes; Amines; Cyclization; Cycloaddition Reaction; Malonates; Oxazoles; Stereoisomerism; Tetrahydroisoquinolines | 2020 |