oxazolidin-2-one has been researched along with linezolid in 2173 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 38 (1.75) | 18.2507 |
| 2000's | 1174 (54.03) | 29.6817 |
| 2010's | 898 (41.33) | 24.3611 |
| 2020's | 63 (2.90) | 2.80 |
| Authors | Studies |
|---|---|
| Barbachyn, MR; Brickner, SJ; Ford, CW; Garmon, SA; Grega, KC; Hendges, SK; Hutchinson, DK; Manninen, PR; Toops, DS; Ulanowicz, DA; Zurenko, GE | 1 |
| Barbachyn, MR; Brickner, SJ; Ford, CW; Hamel, JC; Hutchinson, DK; Moerman, JK; Stapert, D; Wilson, DM; Yancey, RJ | 1 |
| Eliopoulos, GM; Gold, HS; Moellering, RC; Wennersten, CB | 1 |
| Appelbaum, PC; Jacobs, MR; Spangler, SK | 1 |
| Kaplan, SL; Lamberth, LB; Mason, EO | 1 |
| Allison, JW; Barbachyn, MR; Brickner, SJ; Glickman, SE; Hutchinson, DK; Kilburn, JO; Schaadt, RD; Yagi, BH; Zurenko, GE | 1 |
| Erwin, ME; Johnson, DM; Jones, RN | 1 |
| Kaatz, GW; Seo, SM | 1 |
| Drenning, SD; Mulazimoglu, L; Yu, VL | 1 |
| Jorgensen, JH; McElmeel, ML; Trippy, CW | 1 |
| Erwin, ME; Jones, RN; Worth, S | 1 |
| Batts, DH; Daley-Yates, PT; Pawsey, SD; Schaadt, RD; Stalker, DJ; Zurenko, GE | 1 |
| Buysse, JM; Demyan, WF; Dunyak, DS; Lin, AH; Marotti, KR; Melchior, EP; Murray, RW; Shinabarger, DL; Swaney, SM | 1 |
| Biedenbach, DJ; Jones, RN | 3 |
| Aeschlimann, JR; Cappelletty, DM; Kaatz, GW; Moldovan, T; Rybak, MJ | 1 |
| Adamski, JL; Allwine, DA; Barbachyn, MR; Brickner, SJ; Burton, PS; Conradi, RA; Ford, CW; Grega, KC; Hutchinson, DK; Jensen, RM; Klock, JL; Tucker, JA; Zurenko, GE | 1 |
| Aoki, H; Ganoza, MC; Shinabarger, DL; Swaney, SM | 1 |
| Andrews, JM; Ashby, JP; Boswell, FJ; Wise, R | 1 |
| Moellering, RC | 2 |
| Kruzynski, J; Noskin, GA; Peterson, LR; Siddiqui, F; Stosor, V | 1 |
| Chase, S; Cynamon, MH; Klemens, SP; Sharpe, CA | 1 |
| Peters, G; von Eiff, C | 1 |
| Patel, R; Piper, KE; Rouse, MS; Steckelberg, JM | 3 |
| Hamilton-Miller, JM; Shah, S | 1 |
| Barbadora, K; Green, M; Kearney, JA; Mason, EO; Wald, ER | 1 |
| Fresnadillo, MJ; García-Rodríguez, JA; García-Sánchez, E; García-Sánchez, JE; Montes Martínez, I; Trujillano-Martín, I | 1 |
| Hacek, D; Noskin, GA; Peterson, LR; Siddiqui, F; Stosor, V | 1 |
| Hoppe, JE | 1 |
| Sköld, O | 1 |
| Antony, SJ; Bitter, KM; Diaz-Luna, H; Moreland, T; Raudales, F | 1 |
| Kloss, P; Mankin, AS; Shinabarger, DL; Xiong, L | 1 |
| Eliopoulos, GM; Moellering, RC; Schülin, T; Thauvin-Eliopoulos, C | 1 |
| Hopkins, NK; Jungbluth, GL; Sisson, TL | 2 |
| Abdel-Rahman, SM; Kearns, GL | 1 |
| Chien, JW; Kucia, ML; Salata, RA | 1 |
| Johnson, AP; Livermore, DM; Warner, M | 2 |
| Chandrasekar, PH; Clark, NM; Kauffman, CA; McNeil, SA | 1 |
| Albut, R; Figueira, M; Pelton, SI; Stalker, D | 1 |
| Aoyama, H; Aoyama, M; Chiba, K; Igarashi, M; Murata, S; Ozawa, N; Peng, GW; Stryd, RP; Zenki, T | 1 |
| Diekema, DI; Jones, RN | 1 |
| Grucz, RG; Hershberger, E; Moldovan, T; Rybak, MJ | 1 |
| Bowersock, TL; Ford, CW; Portis, ES; Prescott, JF; Robison, DA; Salmon, SA; Watts, JL | 1 |
| MacConnachie, AM | 1 |
| Clemett, D; Markham, A | 1 |
| Lundstrom, TS; Sobel, JD | 1 |
| Fines, M; Leclercq, R | 1 |
| Betriu, C; Boloix, A; Culebras, E; Gómez, M; Palau, ML; Picazo, JJ; Redondo, M; Sánchez, A | 1 |
| Apfalter, P; Hirschl, AM; Makristathis, A; Rotter, ML; Wimmer, M | 1 |
| Goldsmith, D; Gransden, W; Melzer, M | 1 |
| Hauer, MJ; Wienkers, LC; Wynalda, MA | 1 |
| Livermore, DM | 2 |
| Trissel, LA; Williams, KY; Xu, QA; Zhang, Y | 1 |
| Andersen, NM; Douthwaite, S; Kloss, P; Mankin, AS; Shinabarger, DL; Swaney, S; Xiong, L | 1 |
| Batts, DH | 1 |
| Plouffe, JF | 1 |
| Flanagan, PG; Penrose-Stevens, A; Pitman, I; Simpson, BA; Tan, TY | 1 |
| Ballow, CH; Bhavnani, SM | 1 |
| Chen, YC; Ho, SW; Hsueh, PR; Lu, JJ; Luh, KT; Pan, HJ; Teng, LJ; Wu, JJ | 1 |
| Bruss, JB; Duvall, SE; Hafkin, B; McConnell-Martin, MA; Smith, LG; Stevens, DL; Todd, WM | 1 |
| Gardiner, A; Henwood, CJ; James, D; Johnson, AP; Livermore, DM; Warner, M | 1 |
| Acosta, F; Cottagnoud, M; Cottagnoud, P; Gerber, CM; Neftel, K; Täuber, MG | 1 |
| Kupecz, D | 1 |
| Cinelli, R; Corti, G; Paradisi, F | 1 |
| Abdel-Rahman, SM; Blumer, JL; Bradley, JA; Jacobs, RF; James, LP; Jungbluth, GL; Kearns, GL; Reed, MD; Stalker, DJ; Welshman, IR | 1 |
| Bouza, E; Cercenado, E; García-Garrote, F | 1 |
| Chin, KG; Mactal-Haaf, C; McPherson, CE | 1 |
| Muller-Serieys, C | 1 |
| Kite, P; Mills, K; Sugden, S; Wilcox, MH | 1 |
| Cuny, C; Witte, W | 1 |
| Cammarata, S; Oliphant, T; Rubinstein, E; Wunderink, R | 1 |
| Brown-Elliott, BA; Crist, CJ; Mann, LB; Wallace, RJ; Ward, SC; Wilson, RW | 2 |
| Gilbert, NH | 1 |
| Nash, JM | 1 |
| Batts, DH; Buchanan, LV; Dailey, CF; Dileto-Fang, CL; Ford, CW; Gibson, JK; Oramas-Shirey, MP | 2 |
| Barrett, JF | 1 |
| Green, SL; Huttenbach, ED; Maddox, JC | 1 |
| González-Lahoz, JM; Laguna, F; Moreno, V; Valencia, ME | 1 |
| Crouch, CW; Glick, HA; Hafkin, B; Li, Z; Pinto, LA; Pleil, AM; Rittenhouse, BE; Rybak, MJ; Willke, RJ | 1 |
| Gleckman, R | 1 |
| Babcock, HM; Christiansen, E; Little, R; Ritchie, DJ; Stanley, S; Starlin, R | 1 |
| Hidai, H | 1 |
| Fung, HB; Kirschenbaum, HL; Ojofeitimi, BO | 1 |
| DenBesten, K; Gonzales, RD; Graham, MB; Kelkar, S; Quinn, JP; Schreckenberger, PC | 1 |
| Jarvis, B; Perry, CM | 1 |
| Fernández-Roblas, R; Liñares, J; Martín, R; Soriano, F; Tubau, F | 1 |
| Curry, JT; Humphrey, SJ; Stryd, RP; Turman, CN | 1 |
| Norrby, R | 1 |
| Stephenson, J | 1 |
| Bain, KT; Wittbrodt, ET | 1 |
| Andrews, J; Ashby, J; Ellis, R; Gee, T; Marshall, G; Wise, R | 1 |
| Antal, EJ; Batts, DH; Donaldson, KM; Hendershot, PE; Hopkins, NK; Sheu, WP | 1 |
| Antal, EJ; Batts, DH; Hendershot, PE; Hopkins, NK; Welshman, IR | 1 |
| Anderson, DC; Azimi, PH; Blumer, JL; Bradley, JS; Edwards, KM; Kaplan, SL; Lobeck, FG; Patterson, L; Tan, TQ | 1 |
| Alarcón, T; de Las Cuevas, MC; Jiménez, S; López-Brea, S; Pérez, L | 1 |
| Giles, C; Munckhof, WJ; Turnidge, JD | 1 |
| Daschner, FD; Ehrlich, M; Kümmerer, K; Trittler, R | 1 |
| Abdel-Hamid, ME; al-Hassawi, NA; Phillips, OA | 1 |
| Longworth, DL | 1 |
| Furness, K; Klein, JD; Moore, LS; Zaoutis, T | 1 |
| Chosay, J; Millichap, J; Noskin, GA; Peterson, LR; Prystowsky, J; Shinabarger, DL; Siddiqui, F | 1 |
| Ericsson, CD; Peloquin, CA; Shaikh, ZH | 1 |
| Callapina, M; Dietz, A; Hof, H; Kretschmar, M; Mosbach, C; Nichterlein, T | 1 |
| Bruss, JB; Fagerness, PE; Feenstra, KL; Hauer, MJ; Johnson, MG; Peng, GW; Sams, JP; Sanders, PE; Shobe, EM; Slatter, JG; Stalker, DJ; Stryd, RP; Welshman, IR | 1 |
| Noskin, GA | 1 |
| Della-Latta, P; Hammer, SM; Kubin, CJ; Zeana, C | 1 |
| Gemmell, CG | 1 |
| Afif, C; Gokaslan, Z; Hachem, R; Raad, I | 1 |
| Eliopoulos, GM; Ferraro, MJ; Gold, HS; Moellering, RC; Sakoulas, G; Tsiodras, S; Venkataraman, L; Wennersten, C | 1 |
| Cartwright, FD; Kenny, GE | 1 |
| Livermore, DM; Mushtaq, S; Warner, M | 1 |
| Blinkhorn, R; Brown-Elliott, BA; Crist, CJ; Mann, LB; Wallace, RJ | 1 |
| Georgopoulos, A; Graninger, W; Grisold, A; Mueller-Uri, P; Presterl, E | 1 |
| Batts, DH; Eliopoulos, GM; Lavin, BS | 1 |
| Bailey, EM; Faber, MD; Nafziger, DA | 1 |
| Ho, PL; Ng, TK; Que, TL; Tse, CW; Yip, EK; Yuen, KY; Yung, RW | 1 |
| Gikas, A; Psaroulaki, A; Scoulica, E; Spyridaki, I; Tselentis, Y | 1 |
| Borner, E; Borner, K; Lode, H | 1 |
| Lehn, N; Naber, KG; Onda, H; Wagenlehner, FM | 1 |
| Chang, SC; Chen, YC; Fang, CT; Hsieh, SM; Hsieh, WC | 1 |
| Bassetti, D; Bassetti, M; Cenderello, G; Cruciani, M; Del Bono, V; Di Biagio, A; Palermo, A | 1 |
| Jansz, AR; Mouton, JW | 1 |
| MacGowan, AP; Sunderland, J; Tobin, CM; White, LO | 1 |
| Marchese, A; Schito, GC | 1 |
| Bouza, E; Muñoz, P | 1 |
| Antony, SJ; Diaz-Vasquez, E; Stratton, C | 1 |
| Escalante-Fuentes, WG; Gómez-Flores, A; Vera-Cabrera, L; Welsh, O | 1 |
| Gales, AC; Jones, RN; Sader, HS | 1 |
| Kuter, DJ; Tillotson, GS | 1 |
| Betriu, C; Boloix, A; Culebras, E; Gómez, M; Picazo, JJ; Redondo, M | 1 |
| Rao, GG; Steger, A; Tobin, CM | 1 |
| Betlejewska, K; Hryniewicz, K; Nowak, K; Szczypa, K | 1 |
| Hopkins, NK; Jungbluth, GL; Sisson, TA; Stalker, DJ; Welshman, IR | 1 |
| Diekema, DJ; Jones, RN | 1 |
| Wilson, P | 1 |
| Cordeiro, JC; Machado, AM; Reis, AO; Sader, HS | 1 |
| Skiest, DJ; Waldrep, TW | 1 |
| De Vecchi, E; Drago, L; Gismondo, MR; Nicola, L; Valli, M | 1 |
| Andrefsky, JC; De Georgia, MA; Isada, C; Steinmetz, MP; Vogelbaum, MA | 1 |
| Alam, R; Attassi, K; Hershberger, E; Zervos, MJ | 1 |
| Finch, R; Gander, S; Hayward, K | 1 |
| Linden, PK | 2 |
| Blumberg, EA; Ferrin, M; Meagher, A; Zuckerman, JB | 1 |
| Glick, HA; Li, JZ; Rittenhouse, BE; Willke, RJ | 2 |
| Bergomi, R; Cadeo, B; Carosi, G; Cristini, F; Marubbi, F; Pagani, L; Regazzi, MB; Viale, P; Villani, P | 1 |
| Biedenbach, DJ; Della-Latta, P; Jones, RN; Lee, LV | 1 |
| Duff, P | 1 |
| Barry, AL; Brown, SD; Fuchs, PC | 1 |
| Bowker, KE; Holt, HA; MacGowan, AP; Wootton, M | 1 |
| Borner, K; Lode, H; Nord, CE; Von der Höh, N; Ziege, S | 1 |
| Ament, PW; Horne, JP; Jamshed, N | 1 |
| Herrero, IA; Issa, NC; Patel, R | 1 |
| Aoki, H; Gadwood, RC; Ganoza, MC; Ke, L; Poel, TJ; Poppe, SM; Shinabarger, DL; Thomas, RC; Weaver, EA | 1 |
| Bråbäck, M; Forsgren, A; Riesbeck, K | 1 |
| Atkins, JL; Dziewulski, P; Hidvegi, N; Teare, L | 1 |
| Gottlieb, T; Leroi, MJ; Siarakas, S | 1 |
| Balan, D; Li, Z; Nathwani, D; Rittenhouse, B; Vinken, A; Wilike, R | 1 |
| Rybak, MJ | 1 |
| Johnson, AP; Livermore, DM; Tillotson, GS | 1 |
| Nathwani, D | 2 |
| Champney, WS; Miller, M | 1 |
| Huiyuan, G; Yu, D | 1 |
| Gentry-Nielsen, MJ; Olsen, KM; Preheim, LC | 1 |
| Conte, JE; Golden, JA; Kipps, J; Zurlinden, E | 1 |
| Alcalá, L; Alonso, R; Bouza, E; Cuevas, O; Peláez, T; Pérez, C | 1 |
| Krueger, WA; Unertl, KE | 1 |
| Pertel, PE; Till, M; Wixson, RL | 1 |
| Hedström, SA | 1 |
| Durrant, C | 1 |
| Isenberg, J; Prokop, A; Rehm, KE; Seifert, H; Wenchel, HM | 1 |
| Swenson, JM; Tenover, FC | 1 |
| Batts, DH; Hafkin, B; Herr, D; Hunt, JL; Lampiris, H; Stevens, DL | 1 |
| Critchley, IA; Jones, ME; Karlowsky, JA; Kelly, LJ; Sahm, DF; Thornsberry, C | 1 |
| Rehm, SJ | 1 |
| Goetz, MB; Wigen, CL | 1 |
| Biedenbach, DJ; Jones, RN; Mutnick, AH; Turnidge, JD | 1 |
| Ballow, CH; Biedenbach, DJ; Jones, RN | 1 |
| Chuchalin, AG; Fesenko, OV; Fomina, IG; Grudinina, SA; Krotova, LA; Kurdiukova, IuP; Kutsenko, MA; Marinin, VF; Sidorenko, SV; Sinpal'nikov, AI; Solomatin, AS; Sterkhova, GV; Zubkov, MM | 1 |
| Fantin, B | 1 |
| Debbra, E; Marchére, A; Mezzatesta, ML; Nicoletti, G; Schito, AM; Stefani, S; Tempera, G | 1 |
| Blatun, LA | 2 |
| Hoen, B | 1 |
| Bassetti, D; Bassetti, M; Cenderello, G; Di Biagio, A; Melica, G; Rosso, R | 1 |
| Bannister, GC; Brown, JH; Lankester, BJ; Lovering, AM; MacGowan, AP; Narendra, G; Zhang, J | 1 |
| Binstock, P; Keating, M; Kontoyiannis, DP; Nannini, EC; Samonis, G | 1 |
| Grigoris, P; Pareja-Cebrian, L | 1 |
| Halpern, M | 1 |
| Janelle, J; Johns, T; Orrick, JJ; Ramphal, R | 1 |
| Monson, T; Schichman, SA; Zent, CS | 1 |
| Anderegg, TR; Biedenbach, DJ; Jones, RN | 1 |
| Arellano, FM; Bruss, JB; Gerson, SL; Hafkin, B; Kaplan, SL; Kuter, DJ; Le, V | 1 |
| Balli, D; Djuric, SW; Flamm, R; Jolly, R; Marsh, K; Nilius, AM; Pliushchev, M; Sciotti, RJ; Stolarik, D; Ulrich, R; Wiedeman, PE | 1 |
| García-Rodríguez, JA; Gutiérrez Zufiaurre, MN; Muñoz Bellido, JL; Sánchez Hernández, FJ; Segovia Hernández, M; Yagüe Guirao, G | 1 |
| Johnson, AP | 1 |
| Ballow, CH; Biedenbach, DJ; Jones, RN; Rossi, F | 1 |
| Abb, J | 3 |
| Bergomi, R; Carosi, G; Colombini, P; Cristini, F; Pagani, L; Stefini, R; Viale, P | 1 |
| Hau, T | 1 |
| Baum, SE; Crawford, SA; Jorgensen, JH; McElmeel, ML; Whitney, CG | 1 |
| Charavaryamath, C; Das, J; Iqbal, J; Khera, MK; Kumar, MS; Mamidi, RN; Raheem, MA; Rajagopalan, R; Rao, BS; Sarnaik, H; Selvakumar, N; Srinivas, D | 1 |
| Buchanan, LV; Dailey, CF; Gibson, JK; Kuo, MS; LeMay, RJ; Zielinski, RJ | 1 |
| Dahlberg, AE; Mills, JA; O'Connor, M; Thompson, J | 1 |
| Gill, CJ; Hamer, DH; Murphy, MA | 1 |
| Corallo, CE; Paull, AE | 1 |
| Rao, N; White, GJ | 1 |
| Ampofo, K; Graham, PL; Saiman, L | 1 |
| Eliopoulos, GM; Moellering, RC; Wennersten, CB | 1 |
| Hirakata, Y; Kadota, J; Kaneko, Y; Kohno, S; Miyazaki, Y; Murata, I; Sawai, T; Tashiro, T; Tomono, K; Tsukamoto, K; Yanagihara, K | 1 |
| Donskey, CJ; Hutton-Thomas, R; Marshall, SH; Rice, LB; Salata, RA | 1 |
| Maseda, E; Royo, C; Uña, R; Ureta, P | 1 |
| Pagani, L; Viale, P | 1 |
| Kaplan, SL | 2 |
| Guerrero, IC; Ruiz, ME; Tuazon, CU | 1 |
| Dubey, PK; Krishna Reddy, KV; Mahender Rao, S; Moses Babu, J; Om Reddy, G; Suresh, T; Vyas, K | 1 |
| Andes, D; Craig, WA; Peng, J; van Ogtrop, ML | 1 |
| Bercion, R; Carricajo, A; Celard, M; Chomarat, M; Croizé, J; Delubac, F; Fèvre, D; Frédénucci, I; Fuhrmann, C; Helfre, M; Lelièvre, H; Letouzey, MN; Mandjee, A; Marthelet, P; Meley, R; Perrier-Gros-Claude, JD; Ros, A; Roure, C; Smati, S; Thierry, J; Tous, J | 1 |
| Cornell, S | 1 |
| Ford, CW; Gemmell, CG | 1 |
| Borner, K; Burkhardt, O; Köppe, P; Lode, H; Nord, CE; Pletz, MW; von der Höh, N | 1 |
| Auckland, C; Ayles, H; Bamford, K; Cooke, F; Johnson, AP; Jones, G; Kaufmann, ME; Teare, L; Warner, M | 1 |
| Butcher, I; Grigoris, P; Murnaghan, C; Rana, B; Seaton, RA; Tobin, CM | 1 |
| Furuta, I; Kitahashi, T | 2 |
| D'Agata, EM | 1 |
| Gonzales, RD; Pai, MP; Petrolatti, JM; Quinn, JP; Rodvold, KA; Schreckenberger, PC | 1 |
| Allerberger, FJ; Asboth, F; Johnson, AP; Kaufmann, ME; Livermore, DM; Stockdale, MV; Tysall, L; Warner, M; Woodford, N | 1 |
| Adams, LA; Bush, EC; Chiba, K; Daley-Yates, PT; Feenstra, KL; Koike, S; Ozawa, N; Peng, GW; Sams, JP; Schuette, MR; Slatter, JG; Yamazaki, S | 1 |
| Hashimoto, M; Irinoda, K; Nomura, S | 1 |
| Batard, E; Boutoille, D; Bugnon, D; Caillon, J; Hamel, A; Jacqueline, C; Kergueris, MF; Perez, L; Potel, G | 1 |
| Ballesta, S; García, I; Pascual, A; Perea, EJ | 2 |
| Eliopoulos, GM; Ferraro, MJ; Gold, HS; Moellering, RC; Pillai, SK; Sakoulas, G; Wennersten, C | 1 |
| Belova, L; Böttger, EC; Kidan, YG; Mankin, AS; Pfister, P; Sander, P | 1 |
| Barbachyn, MR; Ford, CW; Zurenko, GE | 1 |
| López, M; Rodríguez, JC; Royo, G; Ruiz, M | 1 |
| Hussain, Z; John, MA; Pletch, C | 1 |
| Fujikawa, T; Kobayashi, I; Matsumoto, T; Miyazaki, S; Tateda, K; Yamaguchi, K | 1 |
| Birmingham, MC; Forrest, A; Moise, PA; Schentag, JJ | 1 |
| Cadeo, B; Colombini, P; Cristini, F; Pagani, L; Scolari, C; Viale, P | 1 |
| Al-Hassawi, N; Ali, AA; Phillips, OA; Udo, EE | 1 |
| Cammarata, SK; Oliphant, TH; San Pedro, GS; Todisco, T | 1 |
| Siegel, RE | 1 |
| Andrews, JA; Charlesworth, R; Farrell, DJ; Robbins, M; Singer, M; Walesby, R; Wilson, P | 1 |
| Goff, DA; Mangino, JE; Potoski, BA | 1 |
| Citron, DM; Fernandez, HT; Goldstein, EJ; Merriam, CV; Tyrrell, KL; Warren, YA | 1 |
| Gunderson, BW; Hovde, LB; Ibrahim, KH; Peloquin, CA; Rotschafer, JC | 1 |
| Alcalá, L; Bouza, E; Díaz-Infantes, M; García De Viedma, D; Marín-Arriaza, M; Pérez-Fernández Turégano, C; Ruiz-Serrano, MJ | 1 |
| Grohs, P; Gutmann, L; Kitzis, MD | 1 |
| Paladino, JA | 1 |
| Apodaca, AA; Rakita, RM | 1 |
| Budanov, SV; Smirnova, LB | 1 |
| Ballow, CH; Biedenbach, DJ; Bolmstrom, A; Jones, RN; Qwarnstrom, A | 1 |
| Batts, DH; Birmingham, MC; Flavin, SM; Meagher, AK; Rayner, CR; Schentag, JJ | 1 |
| Johnson, JR | 2 |
| Apodaca, A; Birmingham, MC; Brown-Elliott, BA; Buescher, ES; Gimbel, JF; Moylett, EH; Pacheco, SE; Perry, TR; Rakita, RM; Schentag, JJ; Schwartz, MA; Wallace, RJ | 1 |
| Birmingham, MC; Forrest, A; Meagher, AK; Rayner, CR; Schentag, JJ | 2 |
| Al-Sweih, N; Chugh, TD; Phillips, OA; Udo, EE | 1 |
| Carmona, PM; García, J; Gobernado, M; Monte, E; Romá, E | 1 |
| Ballow, CH; Bell, JM; Jones, RN; Turnidge, JD | 1 |
| Ajdukiewicz, K; Barlow, GD; Clift, B; Davey, P; France, AJ; Gray, K; Morrison, J; Nathwani, D | 1 |
| Larive, LL; Nguyen, CM; Rhoney, DH | 1 |
| Eliopoulos, GM | 2 |
| Pigrau, C | 1 |
| Gross, PA; Levine, JF; Sperber, SJ | 1 |
| Wilson, SE | 1 |
| Ackermann, G; Adler, D; Rodloff, AC | 1 |
| Johnson, AP; Livermore, DM; Malnick, H; Warner, M | 1 |
| Arya, SC | 1 |
| Csapó, Z; Flautner, L; Konkoly, TM; Pulay, I; Tihanyi, T; Zsirka, KA | 1 |
| Ebden, P; Harrison, GA; Lewis, KE; Rees, J; Wooster, SL | 1 |
| Biermacher, JJ; Humphrey, WR; Jensen, JL; Kuo, MS; Richards, IM; Schaadt, RD; Shattuck, MH; Smith, DP; Zielinski, RJ; Zurenko, GE | 1 |
| Lovering, AM; MacGowan, AP; Sunderland, J; Tobin, CM | 1 |
| Bugnon, D; Caillon, J; Donnio, PY; Jacqueline, C; Le Mabecque, V; Miegeville, AF; Potel, G | 1 |
| Bruss, JB; Cammarata, SK; Le, V; Solomkin, JS; Wilson, SE | 1 |
| Mallesham, B; Rajesh, BM; Reddy, PR; Srinivas, D; Trehan, S | 1 |
| Barile, AJ; Bernstein, WB; Rector, JT; Tjaden, JA; Trotta, RF | 1 |
| Boo, TW; Hone, R; Sheehan, G; Walsh, M | 1 |
| Batts, DH; Hopkins, NK; Jungbluth, GL; Stalker, DJ | 1 |
| Nilius, AM | 1 |
| López, M; Rodriguez Díaz, JC; Royo, G; Ruiz, M | 2 |
| Bruss, J; Fleishaker, D; Hilty, M; Naberhuis-Stehouwer, S; Tregnaghi, M; Wible, K | 1 |
| Coque, TM; Novais, C; Peixe, LV; Sousa, JC | 1 |
| Birmingham, MC; Forrest, A; Meagher, AK; Noskin, GA; Rayner, CR; Schentag, JJ; Smith, PF | 1 |
| Knudsen, JD; Skov, RL | 1 |
| Brown-Elliott, BA; Crist, CJ; Mann, LB; Wallace, RJ; Wilson, RW | 1 |
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| Atkinson, GC; Crowe-McAuliffe, C; Hauryliuk, V; Hegstad, K; Huch, S; Kasari, M; Murina, V; Nersisyan, L; Pelechano, V; Sundsfjord, A; Takada, H; Turnbull, KJ; Wilson, DN | 1 |
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| Cai, X; Cao, H; Chen, C; Chen, M; Chen, Z; Dai, H; Dai, Y; Fang, L; Fang, Q; Federico, P; He, L; Hu, Y; Ji, Y; Jiang, S; Li, L; Li, X; Lin, B; Lin, G; Lin, Q; Lu, X; Lv, S; Miao, J; Shi, C; Wang, C; Xu, P; Xu, Q; Xu, T; Xu, Y; Ying, Y; Yu, X; Zhan, H; Zhang, C; Zhang, Y; Zhou, M; Zhu, J; Zhu, Y; Zhu, Z | 1 |
| Bhando, T; Borrillo, L; Brown, ED; Coombes, BK; Farha, MA; Fragis, M; Jardine, E; Johnson, JW; Klobucar, K; MacKinnon, MR; Magolan, J; Nkonge, B; Tsai, CN | 1 |
| Archer, NK; Dikeman, DA; Fotouhi, N; Gordon, O; Gough, E; Kaushik, A; Miller, LS; Mumtaz, M; Nuermberger, EL; Orlando, N; Ortines, RV; Patel, AM; Upton, AM; Wang, Y; Youn, C; Zhang, J | 1 |
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| Bei, C; Chen, X; Chen, Y; Gao, Q; Liu, Q; Meng, J; Pi, R; Wang, C | 1 |
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| Cai, J; Fan, R; Feßler, AT; Fu, J; Gao, Y; Ma, T; Schwarz, S; Sun, C; Wang, Y; Wang, Z; Wu, C; Xie, N; Zhai, W; Zhang, R | 1 |
| Albini, E; Brenciani, A; Cinthi, M; Coccitto, SN; Giovanetti, E; Gobbi, M; Magistrali, CF; Massacci, FR; Pavone, S | 1 |
| Bai, YR; Liu, HM; Shen, DD; Sun, C; Wang, SQ; Yuan, S; Zhang, M; Zhou, L; Zhou, T | 1 |
| Aragaw, WW; Cangialosi, J; Dartois, V; Dick, T; Negatu, DA | 1 |
| Betoudji, F; Converse, PJ; Fotouhi, N; Lee, J; Li, SY; Mdluli, K; Nuermberger, EL; Upton, A | 1 |
| Du, XD; Hao, W; Huang, Y; Ni, J; Schwarz, S; Shan, X; Tang, B; Xu, C; Yan, XM; Yang, H; Zou, C | 1 |
| Pargi, P; Purohit, B; Upadhyay, M | 1 |
| Asiago-Reddy, EA; Blaine, BE; Kufel, WD; Parsels, KA; Seabury, RW; Steele, JM | 1 |
| Han, Z; Li, J; Liu, S; Qiao, W; Tian, T; Yang, M; Yang, X; Zhang, Y | 1 |
| Aarnoutse, R; Boeree, M; Cho, YL; Dierig, A; Geiter, L; Gong, X; Heinrich, N; Hoelscher, M; Hoffmann, L; Jarchow-MacDonald, A; Liyoyo, A; Mbeya, B; McHugh, TD; Mhimbira, FA; Minja, LT; Mpagama, S; Ntinginya, N; Phillips, P; Rassool, M; Schultz, S; Sebe, M; Svensson, EM; Te Brake, L; Wallis, RS; Wildner, LM | 1 |
| Li, H; Li, Z; Lyu, C; Shen, J; Wang, X; Zhang, L | 1 |
| Aires-de-Sousa, M; Bouvier, M; Freire, S; Grilo, T; Poirel, L; Rodrigues, B; Sordo, M | 1 |
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| Jiang, Y; Jiao, L; Liu, P; Luo, Y; Wang, X; Yang, T | 1 |
302 review(s) available for oxazolidin-2-one and linezolid
| Article | Year |
|---|---|
An update on the oxazolidinone antibiotics.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Microbial; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 1999 |
Oxazolidinones: a review.
Topics: Acetamides; Animals; Anti-Infective Agents; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 2000 |
New antibiotics for gram positive infections: linezolid and combination quinapristin/dalfopristin.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Prescriptions; Drug Resistance, Microbial; Drug Therapy, Combination; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazoles; Oxazolidinones; Safety; Virginiamycin | 1999 |
Linezolid.
Topics: Acetamides; Animals; Bacteria; Bacterial Infections; Humans; Linezolid; Oxazoles; Oxazolidinones | 2000 |
Antibiotics for gram-positive bacterial infections. Vancomycin, teicoplanin, quinupristin/dalfopristin, and linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazoles; Oxazolidinones; Teicoplanin; Vancomycin; Virginiamycin | 2000 |
Quinupristin/dalfopristin and linezolid: where, when, which and whether to use?
Topics: Acetamides; Anti-Infective Agents; Clinical Trials as Topic; Drug Approval; Drug Therapy, Combination; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Virginiamycin | 2000 |
Linezolid--a new option for treating gram-positive infections.
Topics: Acetamides; Administration, Oral; Anti-Infective Agents; Cross Infection; Gram-Positive Bacterial Infections; Humans; Immunocompromised Host; Linezolid; Outpatients; Oxazolidinones; Staphylococcal Infections; Vancomycin Resistance | 2000 |
Emerging therapies for serious gram-positive bacterial infections: a focus on linezolid.
Topics: Acetamides; Anti-Infective Agents; Community-Acquired Infections; Cross Infection; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Pneumonia, Bacterial; Skin Diseases, Bacterial | 2000 |
New agents for Gram-positive bacteria.
Topics: Acetamides; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Approval; Fluoroquinolones; Glycopeptides; Gram-Positive Bacterial Infections; Humans; Linezolid; Lipoglycopeptides; Oxazolidinones; Virginiamycin | 2000 |
Use of anti-infective agents during lactation: Part 1--Beta-lactam antibiotics, vancomycin, quinupristin-dalfopristin, and linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; beta-Lactams; Drug Therapy, Combination; Female; Humans; Lactation; Linezolid; Milk, Human; Mothers; Oxazolidinones; Vancomycin; Virginiamycin | 2000 |
[Ketolides and oxazolidinones. Mechanisms of action and antibacterial spectrum].
Topics: Acetamides; Anti-Bacterial Agents; Erythromycin; Gram-Positive Bacterial Infections; Humans; Ketolides; Linezolid; Macrolides; Microbial Sensitivity Tests; Oxazolidinones; Respiratory Tract Infections; Streptococcus; Structure-Activity Relationship | 2000 |
Linezolid Pharmacia Corp.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Contraindications; Humans; Linezolid; Oxazolidinones; Structure-Activity Relationship | 2000 |
What do the new antimicrobials offer? Weighing the advantages and disadvantages compared with traditional agents.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Drug Approval; Drug Resistance, Microbial; Drug Therapy, Combination; Fluoroquinolones; Gatifloxacin; Humans; Linezolid; Moxifloxacin; Oxazolidinones; Patient Selection; Quinolines; Treatment Outcome; United States; United States Food and Drug Administration; Virginiamycin | 2001 |
[Antibiotics--TAZ/PIPC, synercid, linezolid, everninomicin].
Topics: Acetamides; Adult; Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Drug Combinations; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Linezolid; Oxazolidinones; Penicillanic Acid; Penicillins; Piperacillin; Protein Synthesis Inhibitors; Tazobactam; Virginiamycin | 2001 |
Linezolid: an oxazolidinone antimicrobial agent.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Cross Infection; Drug Interactions; Humans; Linezolid; Oxazolidinones; Pneumonia, Bacterial; Soft Tissue Infections; Vancomycin Resistance | 2001 |
Linezolid: a review of its use in the management of serious gram-positive infections.
Topics: Acetamides; Anti-Bacterial Agents; Clinical Trials as Topic; Gram-Positive Bacterial Infections; Humans; Intestinal Absorption; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2001 |
Linezolid--a review of the first oxazolidinone.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Biological Availability; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Community-Acquired Infections; Cross Infection; Gram-Negative Anaerobic Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Randomized Controlled Trials as Topic; Treatment Outcome | 2001 |
Linezolid for the treatment of resistant gram-positive cocci.
Topics: Acetamides; Anti-Bacterial Agents; Drug Interactions; Gram-Positive Bacteria; Half-Life; Humans; Intestinal Absorption; Linezolid; Metabolic Clearance Rate; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Streptococcal Infections | 2001 |
Microbial drug resistance and the roles of the new antibiotics.
Topics: Acetamides; Anti-Infective Agents; Atovaquone; Aza Compounds; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Enterococcus; Fluoroquinolones; Gatifloxacin; Humans; Linezolid; Methicillin Resistance; Moxifloxacin; Naphthoquinones; Oxazolidinones; Proguanil; Pseudomonas aeruginosa; Quinolines; Staphylococcus aureus; Streptococcus pneumoniae; Vancomycin; Vancomycin Resistance; Virginiamycin | 2001 |
Successful treatment of vancomycin-resistant Enterococcus faecium meningitis with linezolid: case report and literature review.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Meningitis, Bacterial; Middle Aged; Oxazolidinones; Treatment Outcome; Vancomycin Resistance | 2001 |
Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci: emerging problems and new prospects for management.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance; Virginiamycin | 2001 |
Vancomycin-resistant Enterococcus faecium meningitis successfully managed with linezolid: case report and review of the literature.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Cerebrospinal Fluid; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Meningitis, Bacterial; Oxazolidinones; Vancomycin Resistance | 2001 |
Linezolid for gram-positive infections.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Drug Resistance, Microbial; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin Resistance; Monoamine Oxidase Inhibitors; Oxazolidinones; Randomized Controlled Trials as Topic; Staphylococcal Infections | 2001 |
Quinupristin/dalfopristin and linezolid: spectrum of activity and potential roles in therapy--a status report.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Area Under Curve; Child; Cross Infection; Drug Combinations; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Tissue Distribution; Virginiamycin | 2001 |
The oxazolidinones as a new family of antimicrobial agent.
Topics: Acetamides; Adult; Animals; Anti-Bacterial Agents; Child; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Mice; Microbial Sensitivity Tests; Oxazolidinones; Rabbits; Rats | 2001 |
Linezolid: pharmacokinetic characteristics and clinical studies.
Topics: Acetamides; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Interactions; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2001 |
Hematologic effects of antimicrobials: focus on the oxazolidinone linezolid.
Topics: Acetamides; Aged; Aged, 80 and over; Anemia; Anti-Infective Agents; Clinical Trials as Topic; Female; Gram-Positive Bacterial Infections; Hematologic Diseases; Humans; Linezolid; Male; Middle Aged; Neutropenia; Oxazolidinones; Polypharmacy; Product Surveillance, Postmarketing; Risk Assessment; Thrombocytopenia; Time Factors | 2001 |
Oxazolidinone antibiotics.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Resistance, Microbial; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Protein Synthesis Inhibitors | 2001 |
Linezolid: a new antibiotic for gram-positive infections.
Topics: Acetamides; Anti-Infective Agents; Drug Costs; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Respiratory Tract Infections; Skin Diseases, Infectious; Soft Tissue Infections | 2001 |
Successful treatment of vancomycin-resistant enterococcus meningitis with linezolid: case report and review of the literature.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Infusions, Intravenous; Linezolid; Male; Meningitis, Bacterial; Oxazolidinones; Vancomycin Resistance; Ventriculostomy | 2001 |
Treatment options for vancomycin-resistant enterococcal infections.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; Enterococcus; Gram-Positive Bacterial Infections; Humans; In Vitro Techniques; Linezolid; Oxazolidinones; Risk Factors; Vancomycin Resistance; Virginiamycin | 2002 |
Antibiotic selection in obstetrics: making cost-effective choices.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Azithromycin; Carbapenems; Cephalosporins; Clindamycin; Cost-Benefit Analysis; Female; Fluoroquinolones; Humans; Linezolid; Metronidazole; Nitrofurantoin; Oxazolidinones; Penicillins; Pregnancy; Pregnancy Complications, Infectious; Trimethoprim, Sulfamethoxazole Drug Combination | 2002 |
Linezolid: its role in the treatment of gram-positive, drug-resistant bacterial infections.
Topics: Acetamides; Anti-Infective Agents; Drug Interactions; Drug Resistance, Microbial; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2002 |
Therapeutic options for Gram-positive infections.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Drugs, Investigational; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Vancomycin Resistance; Virginiamycin | 2001 |
Antimicrobial susceptibility of Gram-positive bacteria: what's current, what's anticipated?
Topics: Acetamides; Anti-Bacterial Agents; Chemistry, Pharmaceutical; Cross Infection; Drug Resistance, Bacterial; Drugs, Investigational; Europe; Gram-Positive Bacterial Infections; Humans; Infection Control; Linezolid; Oxazolidinones; Practice Patterns, Physicians'; United States; Virginiamycin | 2001 |
[New treatment option for gram-positive infections in critically ill patients - overview over linezolid].
Topics: Acetamides; Anti-Bacterial Agents; Critical Illness; Cross Infection; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2002 |
[Linezolide--an antibiotic with new action mechanism].
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Controlled Clinical Trials as Topic; Gram-Positive Bacterial Infections; Humans; Injections, Intravenous; Linezolid; Oxazolidinones; Pneumonia, Bacterial; Randomized Controlled Trials as Topic; Skin Diseases, Bacterial; Soft Tissue Infections | 2002 |
Two new treatment options for infections due to drug-resistant gram-positive cocci.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Drug Interactions; Drug Resistance, Microbial; Drug Therapy, Combination; Enterococcus; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Methicillin; Oxazolidinones; Virginiamycin | 2002 |
[Novel compounds active on staphylococci].
Topics: Acetamides; Anti-Bacterial Agents; Drug Therapy, Combination; Humans; Linezolid; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Virginiamycin | 2002 |
[Linezolid (Zyvox)--a novel antibacterial agent for treatments of multidrug-resistant infections].
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Clinical Trials as Topic; Drug Interactions; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Oxazolidinones; Tissue Distribution | 2002 |
Special issues in the management of infective endocarditis caused by gram-positive cocci.
Topics: Acetamides; Aminoglycosides; Animals; Anti-Bacterial Agents; Disease Management; Drug Resistance; Endocarditis, Bacterial; Enterococcus; Gram-Positive Cocci; Humans; Linezolid; Oxazolidinones; Staphylococcus aureus; Streptococcus; Streptococcus pneumoniae; Virginiamycin | 2002 |
Gram-positive bacterial resistance. A challenge for the next millennium.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Drug Therapy, Combination; Enterococcus; Gram-Positive Bacteria; Humans; Linezolid; Oxazolidinones; Staphylococcus aureus; Vancomycin; Virginiamycin | 2002 |
AZD-2563 AstraZeneca.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Structure-Activity Relationship | 2002 |
Efficacy and safety of linezolid in the treatment of skin and soft tissue infections.
Topics: Acetamides; Anti-Infective Agents; Community-Acquired Infections; Humans; Linezolid; Multicenter Studies as Topic; Oxazolidinones; Randomized Controlled Trials as Topic; Skin Diseases, Bacterial; Soft Tissue Infections | 2002 |
Use of linezolid in children.
Topics: Acetamides; Anti-Infective Agents; Child; Clinical Trials as Topic; Humans; Linezolid; Microbial Sensitivity Tests; Multicenter Studies as Topic; Oxazolidinones; Streptococcal Infections | 2002 |
Antimicrobial-resistant, Gram-positive bacteria among patients undergoing chronic hemodialysis.
Topics: Acetamides; Anti-Bacterial Agents; Chronic Disease; Forecasting; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Renal Dialysis; Staphylococcus aureus; Vancomycin Resistance | 2002 |
[Antimicrobial and clinical effect of linezolid (ZYVOX), new class of synthetic antibacterial drug].
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Drug Resistance, Bacterial; Humans; Linezolid; Mice; Oxazolidinones | 2002 |
The discovery of linezolid, the first oxazolidinone antibacterial agent.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Negative Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Structure-Activity Relationship | 2001 |
Linezolid: an oxazolidinone antimicrobial agent.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; Linezolid; Oxazolidinones | 2002 |
[Linezolid--new antibacterial agent of the oxazolidinone group: its importance in the control of spreading and treatment of the multidrug resistance gram-positive infections].
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Streptococcus | 2002 |
Linezolid: the first oxazolidinone antimicrobial.
Topics: Acetamides; Anti-Infective Agents; Biological Availability; Clinical Trials, Phase III as Topic; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Half-Life; Humans; Linezolid; Oxazolidinones | 2003 |
[Role of linezolid in antimicrobial therapy].
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Bacteria; Drug Interactions; Drug Resistance, Multiple, Bacterial; Enterococcus; Gram-Positive Bacterial Infections; Humans; Injections, Intravenous; Linezolid; Methicillin Resistance; Mycobacterium; Oxazolidinones; Staphylococcus; Streptococcus | 2003 |
Linezolid: implications for neurosurgical infections.
Topics: Acetamides; Animals; Anti-Infective Agents; Cross Infection; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Linezolid; Neurosurgical Procedures; Oxazolidinones | 2003 |
Quinupristin-dalfopristin and linezolid: evidence and opinion.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacteremia; Drug Therapy, Combination; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin Resistance; Virginiamycin | 2003 |
[Oxazolidinones and glycopeptides].
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Biotransformation; Cell Wall; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacterial Infections; Histamine Release; Humans; Linezolid; Molecular Structure; Oxazolidinones; Peptidoglycan; Pneumonia, Bacterial; Protein Synthesis Inhibitors; Staphylococcal Infections; Teicoplanin; Vancomycin | 2003 |
Clinical trial results with linezolid, an oxazolidinone, in the treatment of soft tissue and postoperative gram-positive infections.
Topics: Acetamides; Anti-Infective Agents; Clinical Trials as Topic; Cross Infection; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Soft Tissue Infections; Staphylococcal Infections; Surgical Wound Infection | 2001 |
[Modern potential of antimicrobial therapy in the treatment of wounded soft tissue infections and osteomyelitis].
Topics: Acetamides; Anti-Infective Agents; Bacterial Infections; Humans; Linezolid; Osteomyelitis; Oxazolidinones; Soft Tissue Infections; Wound Infection | 2002 |
Have the oxazolidinones lived up to their billing? Future perspectives for this antibacterial class.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Drug Resistance, Bacterial; Humans; Linezolid; Oxazolidinones | 2003 |
[Other antimicrobial agents (linezolid, quinupristin/dalfopristin, glycylcycline etc)].
Topics: Acetamides; Bacteria; Drug Design; Drug Resistance, Bacterial; Humans; Linezolid; Minocycline; Oxazolidinones; Tetracyclines; Tigecycline; Virginiamycin | 2003 |
[Other antimicrobials (linezolid, quinupristin/dalfopristin)].
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Depression, Chemical; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Virginiamycin | 2003 |
Linezolid in vitro: mechanism and antibacterial spectrum.
Topics: Acetamides; Anti-Bacterial Agents; Colony Count, Microbial; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2003 |
Pharmacokinetic and pharmacodynamic profile of linezolid in healthy volunteers and patients with Gram-positive infections.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2003 |
Efficacy of linezolid versus comparator therapies in Gram-positive infections.
Topics: Acetamides; Anti-Bacterial Agents; Double-Blind Method; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Oxazolidinones; Randomized Controlled Trials as Topic | 2003 |
Safety and tolerability of linezolid.
Topics: Acetamides; Adult; Animals; Anti-Infective Agents; Child; Clinical Trials as Topic; Drug Interactions; Humans; Linezolid; Oxazolidinones | 2003 |
Oxazolidinone structure-activity relationships leading to linezolid.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Linezolid; Molecular Structure; Oxazolidinones; Structure-Activity Relationship | 2003 |
Novelties in the field of antimicrobial compounds for the treatment of lower respiratory tract infections.
Topics: Acetamides; Amidohydrolases; Aminopeptidases; Anti-Bacterial Agents; Area Under Curve; Bacteria; Economics, Pharmaceutical; Half-Life; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Respiratory Tract Infections | 2003 |
New and emerging pediatric infections.
Topics: Acetamides; Child; Drug Resistance, Multiple; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Skin Diseases, Infectious; Staphylococcal Infections | 2003 |
Linezolid: in infants and children with severe Gram-positive infections.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Area Under Curve; Biological Availability; Child; Child, Preschool; Gram-Positive Bacterial Infections; Half-Life; Humans; Infant; Linezolid; Metabolic Clearance Rate; Oxazolidinones; Treatment Outcome | 2003 |
Resistance to linezolid. Are we surprised? How hard should we look?
Topics: Acetamides; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2003 |
Linezolid and quinupristin/dalfopristin: novel antibiotics for gram-positive infections of the skin.
Topics: Acetamides; Anti-Bacterial Agents; Biological Availability; Drug Therapy, Combination; Gram-Positive Bacterial Infections; Half-Life; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Randomized Controlled Trials as Topic; Skin Diseases, Bacterial; Virginiamycin | 2003 |
Treatment of gram-positive surgical sepsis: role of the oxazolidinones.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Biological Availability; Drug Resistance, Microbial; Gram-Positive Bacterial Infections; Humans; Infusions, Intravenous; Linezolid; Oxazolidinones; Postoperative Complications; Sepsis | 2003 |
Antimicrobial resistance among gram-positive organisms in the intensive care unit.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Community-Acquired Infections; Drug Resistance, Microbial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcus aureus; Treatment Outcome; United States; Vancomycin; Virginiamycin | 2003 |
Cutaneous infections in the elderly: diagnosis and management.
Topics: 2-Aminopurine; Acetamides; Acyclovir; Aged; Anti-Bacterial Agents; Antidepressive Agents, Tricyclic; Antiviral Agents; Famciclovir; Herpes Zoster; Humans; Itraconazole; Linezolid; Onychomycosis; Oxazolidinones; Skin Diseases, Infectious; Virginiamycin | 2003 |
Linezolid pharmacokinetics in pediatric patients: an overview.
Topics: Absorption; Acetamides; Adult; Age Factors; Anti-Infective Agents; Child; Child, Preschool; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Gram-Positive Bacterial Infections; Half-Life; Humans; Infant; Infant, Newborn; Infant, Premature; Linezolid; Mass Spectrometry; Oxazolidinones; Tissue Distribution | 2003 |
Linezolid for the treatment of methicillin-resistant Staphylococcus aureus infections in children.
Topics: Acetamides; Administration, Oral; Adolescent; Anti-Bacterial Agents; Cefadroxil; Child; Child, Preschool; Double-Blind Method; Female; Humans; Infusions, Intravenous; Linezolid; Male; Methicillin Resistance; Outpatients; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2003 |
Clinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterial.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Biological Availability; Clinical Trials as Topic; Drug Interactions; Half-Life; Humans; Injections, Intravenous; Kidney; Linezolid; Oxazolidinones | 2003 |
Vancomycin-resistant Enterococcus faecium endocarditis in a premature infant successfully treated with linezolid.
Topics: Acetamides; Anti-Infective Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Endocarditis, Bacterial; Enterococcus faecium; Follow-Up Studies; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Infant, Premature; Infusions, Intravenous; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Risk Assessment; Treatment Outcome; Vancomycin Resistance | 2003 |
Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolid.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Area Under Curve; Bacterial Infections; Glycopeptides; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2003 |
[How effective are linezolid and telithromycin? The resistance situation of pathogenic gram positive infections in Germany].
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Germany; Gram-Positive Bacterial Infections; Humans; Ketolides; Linezolid; Macrolides; Oxazolidinones | 2004 |
[Two new antibiotics with special qualities: the pharmacokinetics of linezolid and telithromycin].
Topics: Acetamides; Adult; Aging; Anti-Bacterial Agents; Child; Drug Interactions; Humans; Infant, Newborn; Ketolides; Linezolid; Liver Diseases; Macrolides; Oxazolidinones; Renal Insufficiency | 2004 |
[Action in nosocomial pneumonia and severe skin and soft tissue infections. Linezolid in treatment].
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Pneumonia, Bacterial; Skin Diseases, Infectious; Soft Tissue Infections | 2004 |
[Adverse effects of anti-infectives. Undesirable effects and interactions of ketolides and oxazolidonones].
Topics: Acetamides; Anti-Bacterial Agents; Drug Interactions; Humans; Ketolides; Linezolid; Macrolides; Oxazolidinones | 2004 |
Novel antibacterial agents for skin and skin structure infections.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Humans; Linezolid; Oxazolidinones; Quinolones; Skin Diseases, Bacterial; Soft Tissue Infections; Virginiamycin | 2004 |
Oxazolidinones: activity, mode of action, and mechanism of resistance.
Topics: Acetamides; Anti-Infective Agents; Base Sequence; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Molecular Sequence Data; Mutation; Oxazolidinones; Peptidyl Transferases; RNA, Ribosomal, 23S | 2004 |
[Linezolid (Zyvoxid)].
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Oxazolidinones | 2004 |
Coagulase-negative staphylococcal disease: emerging therapies for the neonatal and pediatric patient.
Topics: Acetamides; Anti-Infective Agents; Child; Child, Preschool; Coagulase; Drug Resistance, Bacterial; Humans; Infant; Infant, Newborn; Linezolid; Oxazolidinones; Staphylococcal Infections; Staphylococcal Vaccines; Staphylococcus; Treatment Outcome; Vancomycin | 2004 |
Linezolid, quinupristin/dalfopristin, and daptomycin in dermatology.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Half-Life; Humans; Linezolid; Metabolic Clearance Rate; Oxazolidinones; Skin Diseases, Bacterial; Virginiamycin | 2004 |
[Linezolid (Zivox), a new highly efficient antibiotic for therapy of Gram-positive infections].
Topics: Acetamides; Anti-Bacterial Agents; Clinical Trials as Topic; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2004 |
Peripheral neuropathy associated with prolonged use of linezolid.
Topics: Acetamides; Anti-Infective Agents; Female; Growth; Humans; Linezolid; Middle Aged; Oxazolidinones; Peripheral Nervous System Diseases; Staphylococcal Infections | 2004 |
[The role of linezolid in the therapy of infections caused by multiresistant gram-positive cocci].
Topics: Acetamides; Anti-Bacterial Agents; Drug Costs; Drug Resistance, Multiple, Bacterial; Glycopeptides; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Streptococcal Infections | 2004 |
The safety and efficacy of linezolid in orthopaedic practice for the treatment of infection due to antibiotic-resistant organisms.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Arthritis, Infectious; Bacterial Infections; Child; Clinical Trials as Topic; Comorbidity; Drug Costs; Drug Interactions; Drug Resistance, Multiple, Bacterial; Gastrointestinal Diseases; Hematologic Diseases; Humans; Kidney Diseases; Linezolid; Musculoskeletal Diseases; Nervous System Diseases; Optic Nerve Diseases; Osteomyelitis; Oxazolidinones; Prosthesis-Related Infections; Randomized Controlled Trials as Topic; Treatment Outcome | 2004 |
New drugs for Gram-positive uropathogens.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Urinary Tract Infections; Urine | 2004 |
[Linezolid, an agent from a new class of antibiotics].
Topics: Acetamides; Administration, Oral; Anti-Infective Agents; Bacteria, Anaerobic; Biological Availability; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2004 |
Enterococcus faecalis resistant to linezolid: case series and review of the literature.
Topics: Acetamides; Aged; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones | 2004 |
Antimicrobial resistance to linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Humans; Linezolid; Oxazolidinones; Staphylococcus; Streptococcus pneumoniae | 2004 |
Antibiotic resistance in Staphylococcus aureus: concerns, causes and cures.
Topics: Acetamides; Drug Design; Drug Resistance, Bacterial; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcus aureus; Vancomycin Resistance | 2003 |
A review of linezolid: the first oxazolidinone antibiotic.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacteria; Clinical Trials as Topic; Food-Drug Interactions; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia | 2004 |
Alternatives for MRSA treatment in the pediatric patient.
Topics: Acetamides; Adolescent; Adult; Anti-Infective Agents; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2004 |
Update on the use of linezolid: a pediatric perspective.
Topics: Acetamides; Anti-Bacterial Agents; Child; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Oxazolidinones | 2004 |
Recent advances in the treatment of infections due to resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Multiple, Bacterial; Glycopeptides; Humans; Linezolid; Lipoglycopeptides; Minocycline; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Tigecycline; Virginiamycin | 2004 |
Newer antistaphylococcal agents.
Topics: Acetamides; Anti-Bacterial Agents; Child; Drug Resistance, Bacterial; Glycopeptides; Humans; Linezolid; Oxazolidinones; Protein Synthesis Inhibitors; Staphylococcus aureus | 2005 |
Serotonin toxicity associated with concomitant use of linezolid.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Child, Preschool; Cyclohexanols; Drug Interactions; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Serotonin Agents; Serotonin Syndrome; Venlafaxine Hydrochloride | 2005 |
Role of linezolid in the treatment of orthopedic infections.
Topics: Acetamides; Anti-Bacterial Agents; Arthritis, Infectious; Bone Diseases, Infectious; Humans; Linezolid; Oxazolidinones; Prosthesis-Related Infections | 2005 |
Severe staphylococcal knee arthritis responding favourably to linezolid, after glycopeptide-rifampicin failure: a case report and literature review.
Topics: Acetamides; Anti-Bacterial Agents; Arthritis, Infectious; Drug Therapy, Combination; HIV Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Rifampin; Staphylococcal Infections; Teicoplanin; Vancomycin | 2005 |
Recent developments in the discovery of novel oxazolidinone antibacterials.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Linezolid; Oxazoles; Oxazolidinones | 2005 |
Clinical characteristics of linezolid-resistant Staphylococcus aureus infections.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Humans; Linezolid; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2005 |
Oxazolidinones--a new class of broad-spectrum chemotherapeutics.
Topics: Acetamides; Anti-Infective Agents; Clinical Trials as Topic; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Protein Synthesis Inhibitors | 2004 |
Linezolid: a pharmacoeconomic review of its use in serious Gram-positive infections.
Topics: Acetamides; Anti-Infective Agents; Clinical Trials as Topic; Cost-Benefit Analysis; Economics, Pharmaceutical; Gram-Positive Bacterial Infections; Humans; Linezolid; Models, Economic; Oxazolidinones | 2005 |
New antibiotics for the treatment of severe staphylococcal infection in the critically ill patient.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Cephalosporins; Clinical Trials as Topic; Critical Illness; Daptomycin; Drug Resistance, Multiple, Bacterial; Glycopeptides; Humans; Linezolid; Lipoglycopeptides; Methicillin Resistance; Minocycline; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Tigecycline; Virginiamycin | 2005 |
Linezolid treatment of ventriculoperitoneal shunt infection without implant removal.
Topics: Acetamides; Anti-Bacterial Agents; Device Removal; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Ventriculoperitoneal Shunt | 2005 |
Linezolid versus vancomycin for Staphylococcus aureus bacteraemia: pooled analysis of randomized studies.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacteremia; Female; Humans; Linezolid; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Oxazolidinones; Randomized Controlled Trials as Topic; Retrospective Studies; Staphylococcal Infections; Staphylococcus aureus; Survival Analysis; Treatment Outcome; Vancomycin | 2005 |
Antibiotic resistance in Staphylococcus aureus and its relevance in therapy.
Topics: Acetamides; Anti-Bacterial Agents; beta-Lactams; Clinical Trials as Topic; Drug Resistance, Bacterial; Glycopeptides; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Penicillins; Staphylococcal Infections; Staphylococcus aureus; Vaccination; Vaccines, DNA; Vancomycin; Vancomycin Resistance | 2005 |
Update on linezolid: the first oxazolidinone antibiotic.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Positive Cocci; Humans; Injections, Intravenous; Linezolid; Oxazolidinones; Pneumonia, Bacterial; Practice Guidelines as Topic; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Skin Diseases, Bacterial; Soft Tissue Infections; Teicoplanin; Vancomycin | 2005 |
Treatment approaches for community-acquired methicillin-resistant Staphylococcus aureus infections.
Topics: Acetamides; Anti-Bacterial Agents; Community-Acquired Infections; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2005 |
[Linezolid, the first oxazolidinone antibiotic].
Topics: Acetamides; Anti-Infective Agents; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Protein Synthesis Inhibitors; Staphylococcus | 2005 |
Spread of ampicillin/vancomycin-resistant Enterococcus faecium of the epidemic-virulent clonal complex-17 carrying the genes esp and hyl in German hospitals.
Topics: Acetamides; Ampicillin Resistance; Anti-Infective Agents; Bacterial Proteins; Cross Infection; DNA Restriction Enzymes; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Germany; Gram-Positive Bacterial Infections; Humans; Hyaluronoglucosaminidase; Linezolid; Membrane Proteins; Oxazolidinones; Phenotype; Phylogeny; Polymerase Chain Reaction; Vancomycin Resistance | 2005 |
Methicillin-Resistant S. aureus Ventilator-Associated Pneumonia: Strategies to Prevent and Treat.
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia, Bacterial; Risk Factors; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance; Ventilators, Mechanical | 2006 |
Infective endocarditis treated with linezolid: case report and literature review.
Topics: Acetamides; Anti-Infective Agents; Endocarditis, Bacterial; Female; Heart Valve Diseases; Humans; Linezolid; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Streptococcal Infections; Treatment Outcome; Viridans Streptococci | 2006 |
Anticipating potential linezolid-SSRI interactions in the general hospital setting: an MAOI in disguise.
Topics: Acetamides; Aged; Drug Interactions; Female; Humans; Linezolid; Male; Middle Aged; Monoamine Oxidase Inhibitors; Oxazolidinones; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Sertraline | 2006 |
Antibacterial drug discovery and structure-based design.
Topics: Acetamides; Amino Acyl-tRNA Synthetases; Animals; Anti-Bacterial Agents; Bacteria; Crystallography, X-Ray; DNA Topoisomerases, Type II; Drug Design; Drug Resistance, Bacterial; Humans; Linezolid; Models, Molecular; Molecular Structure; Monoamine Oxidase Inhibitors; Oxazolidinones; Protein Biosynthesis; Structure-Activity Relationship; Topoisomerase II Inhibitors; Transcription, Genetic | 2006 |
Serotonin toxicity associated with the use of linezolid: a review of postmarketing data.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Monoamine Oxidase Inhibitors; Oxazolidinones; Product Surveillance, Postmarketing; Serotonin Syndrome | 2006 |
Management of infections of osteoarticular prosthesis.
Topics: Acetamides; Anti-Infective Agents; Drug Therapy, Combination; Fluoroquinolones; Fusidic Acid; Humans; Joint Prosthesis; Linezolid; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Trimethoprim, Sulfamethoxazole Drug Combination | 2006 |
Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence.
Topics: Acetamides; Anti-Bacterial Agents; Endocarditis, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2006 |
Role of linezolid in the treatment of complicated skin and soft tissue infections.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Linezolid; Oxazolidinones; Skin Diseases, Infectious; Soft Tissue Infections | 2006 |
Bell's palsy associated with linezolid therapy: case report and review of neuropathic adverse events.
Topics: Acetamides; Anti-Infective Agents; Bell Palsy; Diabetes Mellitus, Type 1; Drug Monitoring; Humans; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones | 2006 |
Clinical experience with recently approved antibiotics.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Infections; Daptomycin; Humans; Linezolid; Minocycline; Oxazolidinones; Staphylococcal Infections; Streptococcal Infections; Tigecycline; Virginiamycin | 2006 |
In vitro activity of daptomycin against clinical isolates with reduced susceptibilities to linezolid and quinupristin/dalfopristin.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacteria; Humans; Linezolid; Oxazolidinones; Staphylococcus aureus; Virginiamycin | 2006 |
Dalbavancin: a review for dermatologists.
Topics: Acetamides; Adult; Animals; Catheterization; Clinical Trials, Phase III as Topic; Cross Infection; Double-Blind Method; Drug Resistance, Multiple, Bacterial; Enterococcus; Female; Fever; Gram-Positive Bacterial Infections; Headache; Humans; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Rabbits; Randomized Controlled Trials as Topic; Skin Diseases, Bacterial; Staphylococcal Skin Infections; Teicoplanin; Treatment Outcome; Vancomycin | 2006 |
Risk of serotonin syndrome with concomitant administration of linezolid and serotonin agonists.
Topics: Acetamides; Anti-Bacterial Agents; Antidepressive Agents, Second-Generation; Clinical Trials, Phase I as Topic; Drug Synergism; Humans; Linezolid; Monoamine Oxidase Inhibitors; Oxazolidinones; Risk; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome | 2006 |
Antimycobacterial activities of oxazolidinones: a review.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium; Oxazolidinones; Tuberculosis | 2006 |
Linezolid-induced optic neuropathy: a mitochondrial disorder?
Topics: Acetamides; Anti-Infective Agents; Child; Fluorescein Angiography; Humans; Linezolid; Male; Mandibular Diseases; Mitochondrial Diseases; Nerve Fibers; Optic Nerve Diseases; Osteomyelitis; Oxazolidinones; Retina; Vision Disorders; Visual Acuity | 2007 |
Use of linezolid in children: an overview of recent advances.
Topics: Acetamides; Anti-Bacterial Agents; Child; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2006 |
Vancomycin-resistant Enterococcus faecalis endocarditis: linezolid failure and strain characterization of virulence factors.
Topics: Acetamides; Adult; Anti-Infective Agents; Bacterial Proteins; Endocarditis, Bacterial; Enterococcus faecalis; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Treatment Failure; Vancomycin Resistance; Virulence; Virulence Factors | 2007 |
Linezolid for the treatment of adults with bone and joint infections.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Arthritis, Infectious; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Osteomyelitis; Oxazolidinones; Peripheral Nervous System Diseases | 2007 |
Linezolid: a new antibiotic for newborns and children?
Topics: Acetamides; Anti-Infective Agents; Bacterial Infections; Child; Child, Preschool; Cross Infection; Humans; Infant; Infant, Newborn; Linezolid; Oxazolidinones; Treatment Outcome | 2006 |
Linezolid for the treatment of patients with central nervous system infection.
Topics: Acetamides; Anti-Bacterial Agents; Central Nervous System Bacterial Infections; Clinical Trials as Topic; Humans; Linezolid; Oxazolidinones; Treatment Outcome | 2007 |
Pharmacologic treatment options for nosocomial pneumonia involving methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Humans; Linezolid; MEDLINE; Methicillin Resistance; Oxazolidinones; Pneumonia, Staphylococcal; Staphylococcus aureus; Vancomycin | 2007 |
[Linezolid--novel antibiotic for the treatment of gram-positive bacterial infections].
Topics: Acetamides; Anti-Infective Agents; Arthritis, Infectious; Bone Diseases, Infectious; Clinical Trials as Topic; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Pneumonia; Prosthesis-Related Infections | 2006 |
[Linezolid].
Topics: Acetamides; Animals; Anti-Infective Agents; Clinical Trials as Topic; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Pneumonia, Staphylococcal; Treatment Outcome; Vancomycin Resistance | 2007 |
[CA-MRSA].
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Chromosomes, Bacterial; Clindamycin; Community-Acquired Infections; Exotoxins; Humans; Leukocidins; Linezolid; Methicillin Resistance; Oxazolidinones; Penicillin-Binding Proteins; Staphylococcal Infections; Staphylococcus aureus | 2007 |
An infection with linezolid-resistant S. aureus in a patient with left ventricular assist system.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Germany; Heart-Assist Devices; Humans; Linezolid; Male; Methicillin; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus aureus | 2007 |
Antimicrobial symposium. Part VIII. Glycopeptides, oxazolidinones, and lipopeptides.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Daptomycin; Drug Resistance, Microbial; Glycopeptides; Humans; Linezolid; Molecular Structure; Oxazolidinones; Peptides, Cyclic; Vancomycin | 2007 |
[Therapeutic perspectives of linezolid in the management of infections due to multiresistant Gram-positive pathogens].
Topics: Acetamides; Administration, Oral; Anti-Infective Agents; Daptomycin; Drug Resistance, Multiple, Bacterial; Enterococcus; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Injections, Intravenous; Linezolid; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Practice Guidelines as Topic; Staphylococcus aureus; Streptococcus pneumoniae; Teicoplanin; Tigecycline; Time Factors; Vancomycin; Virginiamycin | 2007 |
[Vancomycin resistant enterococci infection].
Topics: Acetamides; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Vancomycin Resistance | 2007 |
Linezolid for the treatment of patients with [corrected] mycobacterial infections [corrected] a systematic review.
Topics: Acetamides; Adolescent; Adult; Anemia; Anti-Infective Agents; Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Humans; Linezolid; Male; Middle Aged; Mycobacterium avium-intracellulare Infection; Mycobacterium Infections, Nontuberculous; Optic Nerve Diseases; Oxazolidinones; Peripheral Nervous System Diseases; Treatment Outcome; Tuberculosis | 2007 |
Combating the growing problem of methicillin-resistant Staphylococcus aureus: do the newer antibiotics represent a better alternative to vancomycin?
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Linezolid; Methicillin Resistance; Minocycline; Oxazolidinones; Staphylococcus aureus; Tigecycline; Vancomycin; Virginiamycin | 2007 |
Lactic acidosis after treatment with linezolid.
Topics: Acetamides; Acidosis, Lactic; Aged, 80 and over; Anti-Infective Agents; Cardiac Surgical Procedures; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Vancomycin Resistance | 2007 |
Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome.
Topics: Acetamides; Acidosis, Lactic; Anti-Infective Agents; Drug Interactions; Female; Humans; Linezolid; Male; Optic Nerve Diseases; Oxazolidinones; Peripheral Nervous System Diseases; Risk Factors; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome | 2007 |
Novel agents in the management of Mycobacterium tuberculosis disease.
Topics: Acetamides; Antitubercular Agents; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Linezolid; Mycobacterium Infections; Mycobacterium tuberculosis; Oxazolidinones; Protease Inhibitors; Reverse Transcriptase Inhibitors; Rifampin; Vaccines | 2007 |
[Toxicity of recent and less recent drugs on the optic nerve. Does Viagra cause blindness?].
Topics: Acetamides; Amiodarone; Blindness; Ethambutol; Humans; Immunosuppressive Agents; Interferon-alpha; Linezolid; Optic Nerve; Optic Nerve Diseases; Oxazolidinones; Phosphodiesterase Inhibitors; Tamoxifen; Tumor Necrosis Factor-alpha | 2007 |
Linezolid for the treatment of Nocardia spp. infections.
Topics: Acetamides; Animals; Humans; Linezolid; Nocardia; Nocardia Infections; Oxazolidinones; Retrospective Studies | 2007 |
Methicillin-resistant Staphylococcus epidermidis (MRSE) endocarditis treated with linezolid.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Endocarditis, Bacterial; Humans; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus epidermidis | 2008 |
Linezolid: effectiveness and safety for approved and off-label indications.
Topics: Acetamides; Animals; Anti-Infective Agents; Humans; Linezolid; Oxazolidinones | 2007 |
Selecting anti-infective agents for the treatment of bone infections: new anti-infective agents and chronic suppressive therapy.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bone Diseases, Infectious; Daptomycin; Humans; Linezolid; Minocycline; Osteomyelitis; Oxazolidinones; Tigecycline | 2007 |
Treatment of infections caused by resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Humans; Linezolid; Methicillin Resistance; Minocycline; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Tigecycline; Vancomycin; Virginiamycin | 2007 |
Effect of linezolid on the occurrence of vancomycin-resistant enterococci.
Topics: Acetamides; Enterococcus; Humans; Linezolid; Oxazolidinones; Vancomycin Resistance | 2007 |
Optimizing therapy for MRSA pneumonia.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Daptomycin; Humans; Linezolid; Methicillin Resistance; Minocycline; Oxazolidinones; Pneumonia, Bacterial; Staphylococcus aureus; Tigecycline; Vancomycin | 2007 |
Optimizing therapy for methicillin-resistant Staphylococcus aureus bacteremia.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Daptomycin; Endocarditis; Equipment Contamination; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcus aureus; Vancomycin | 2007 |
Optimizing therapy for vancomycin-resistant enterococci (VRE).
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Cross Infection; Drug Resistance, Microbial; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Vancomycin | 2007 |
Linezolid versus glycopeptide or beta-lactam for treatment of Gram-positive bacterial infections: meta-analysis of randomised controlled trials.
Topics: Acetamides; Adolescent; Adult; beta-Lactams; Drug Resistance, Multiple, Bacterial; Glycopeptides; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Randomized Controlled Trials as Topic | 2008 |
Drug-induced optic neuropathies.
Topics: Acetamides; Adverse Drug Reaction Reporting Systems; Amiodarone; Anti-Arrhythmia Agents; Anti-Infective Agents; Antitubercular Agents; Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Ethambutol; Humans; Linezolid; Optic Nerve Diseases; Oxazolidinones; Phosphodiesterase Inhibitors | 2007 |
Linezolid in children: recent patents and advances.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Infections; Child; Drug Resistance, Bacterial; Humans; Linezolid; Oxazolidinones; Patents as Topic | 2007 |
Linezolid - the first oxazolidinone in the treatment of nosocomial MRSA pneumonia.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Cross Infection; Drug Interactions; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Patents as Topic; Staphylococcal Infections; Staphylococcus aureus | 2007 |
New antimicrobial agents for the treatment of Gram-positive bacterial infections.
Topics: Acetamides; Anti-Infective Agents; Cephalosporins; Daptomycin; Glycopeptides; Gram-Positive Bacterial Infections; Linezolid; Minocycline; Oxazolidinones; Tigecycline; Virginiamycin | 2008 |
Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones | 2008 |
Pharmacoeconomics of linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Clinical Trials as Topic; Costs and Cost Analysis; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Models, Econometric; Oxazolidinones; Quality of Life; Staphylococcus aureus; Teicoplanin; Vancomycin | 2008 |
[Pharmacological rationale for choice of antibiotics for intraabdominal infections].
Topics: Abdominal Abscess; Acetamides; Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; beta-Lactams; Digestive System Diseases; Drug Therapy, Combination; Fluoroquinolones; Humans; Linezolid; Metronidazole; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Peritonitis; Sepsis; Tigecycline; Treatment Outcome; Virginiamycin | 2008 |
[New anti-Gram+antibiotics: which role in infective endocarditis?].
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Endocarditis; Gram-Positive Bacterial Infections; Humans; Linezolid; Minocycline; Oxazolidinones; Tigecycline; Virginiamycin | 2008 |
Pneumonia caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Community-Acquired Infections; Cross Infection; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2008 |
Linezolid.
Topics: Acetamides; Animals; Antitubercular Agents; Humans; Linezolid; Oxazolidinones; Treatment Outcome; Tuberculosis | 2008 |
Methicillin-resistant Staphylococcus aureus: an update for the dermatologist, Part 3: Clinical management.
Topics: Acetamides; Algorithms; Anti-Bacterial Agents; Clindamycin; Community-Acquired Infections; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Skin Infections; Staphylococcus aureus; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin | 2008 |
Health care-associated pneumonia: identification and initial management in the ED.
Topics: Acetamides; Age Distribution; Aged; Aged, 80 and over; Anti-Infective Agents; beta-Lactams; Cephalosporins; Cross Infection; Emergency Treatment; Ertapenem; Female; Humans; Length of Stay; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Minocycline; Oxazolidinones; Patient Care Team; Pneumonia, Bacterial; Pneumonia, Ventilator-Associated; Practice Guidelines as Topic; Respiration, Artificial; Risk Factors; Severity of Illness Index; Tigecycline | 2008 |
[Skin and soft tissue infections: current therapeutic options].
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Daptomycin; Humans; Linezolid; Methicillin Resistance; Middle Aged; Minocycline; Oxazolidinones; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Skin Diseases, Infectious; Soft Tissue Infections; Staphylococcal Skin Infections; Staphylococcus aureus; Tigecycline; Time Factors; Treatment Outcome | 2008 |
[Adverse effect optic neuropathy].
Topics: Acetamides; Amiodarone; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antitubercular Agents; Drug-Related Side Effects and Adverse Reactions; Ethambutol; Humans; Linezolid; Optic Nerve Diseases; Oxazolidinones | 2008 |
Benefit-risk assessment of linezolid for serious gram-positive bacterial infections.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Randomized Controlled Trials as Topic | 2008 |
Antimicrobial agents in treatment of MRSA infections.
Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Clindamycin; Community-Acquired Infections; Daptomycin; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fluoroquinolones; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Minocycline; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Tetracyclines; Tigecycline; Trimethoprim, Sulfamethoxazole Drug Combination; United States; Vancomycin | 2008 |
Update on medication-induced peripheral neuropathy.
Topics: Acetamides; Anti-Infective Agents; Antibodies, Monoclonal; Antirheumatic Agents; Clinical Trials as Topic; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Linezolid; Oxazolidinones; Peripheral Nervous System Diseases; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2009 |
Therapeutic challenges in the era of antibiotic resistance.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Daptomycin; Drug Resistance, Microbial; Humans; Linezolid; Minocycline; Oxazolidinones; Tigecycline | 2008 |
Association of pharmacokinetic and pharmacodynamic aspects of linezolid with infection outcome.
Topics: Acetamides; Anti-Bacterial Agents; Biological Availability; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Randomized Controlled Trials as Topic; Tissue Distribution | 2009 |
Cost-effectiveness analysis of linezolid vs. vancomycin in treating methicillin-resistant Staphylococcus aureus complicated skin and soft tissue infections using a decision analytic model.
Topics: Acetamides; Cost-Benefit Analysis; Decision Support Techniques; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Risk Factors; Soft Tissue Infections; Staphylococcal Infections; Staphylococcal Skin Infections; Vancomycin | 2009 |
New antimicrobial molecules and new antibiotic strategies.
Topics: Acetamides; Anti-Infective Agents; beta-Lactams; Cephalosporins; Community-Acquired Infections; Drug Design; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Ertapenem; Fluoroquinolones; Humans; Ketolides; Linezolid; Lipopeptides; Oxazolidinones; Pneumonia, Bacterial; Practice Guidelines as Topic | 2009 |
Linezolid for patients with neutropenia: are bacteriostatic agents appropriate?
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topic; Female; Humans; Linezolid; Male; Neutropenia; Oxazolidinones; Prognosis | 2009 |
Update on the safety of linezolid.
Topics: Acetamides; Anti-Infective Agents; Bell Palsy; Child; Child, Preschool; Clinical Trials, Phase III as Topic; Drug Interactions; Female; Humans; Infant; Infections; Kidney Diseases; Linezolid; Oxazolidinones; Pregnancy | 2009 |
New treatments for methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Clinical Trials as Topic; Daptomycin; Evidence-Based Medicine; Glycopeptides; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Minocycline; Oxazolidinones; Pyrimidines; Streptococcal Infections; Tigecycline | 2009 |
Treatment options for nosocomial pneumonia due to MRSA.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Pneumonia, Ventilator-Associated; Vancomycin | 2009 |
Linezolid: a review of safety and tolerability.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Drug Interactions; Drug Tolerance; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Monoamine Oxidase Inhibitors; Oxazolidinones; Pneumonia, Bacterial; Selective Serotonin Reuptake Inhibitors | 2009 |
Linezolid versus vancomycin for MRSA skin and soft tissue infections (systematic review and meta-analysis).
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Randomized Controlled Trials as Topic; Soft Tissue Infections; Staphylococcal Infections; Staphylococcal Skin Infections; Vancomycin | 2009 |
Linezolid versus vancomycin for the treatment of gram-positive bacterial infections: meta-analysis of randomised controlled trials.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Drug-Related Side Effects and Adverse Reactions; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Pneumonia, Bacterial; Randomized Controlled Trials as Topic; Skin Diseases, Bacterial; Soft Tissue Infections; Treatment Outcome; Vancomycin | 2010 |
[Update on antimicrobial chemotherapy].
Topics: Acetamides; Aminoglycosides; Anti-Infective Agents; beta-Lactams; Carbapenems; Cephalosporins; Daptomycin; Doripenem; Drug Resistance, Bacterial; Ertapenem; Fluoroquinolones; France; Humans; Linezolid; Lipoglycopeptides; Minocycline; Oxazolidinones; Penicillins; Pyrimidines; Teicoplanin; Tigecycline | 2010 |
Efficacy and safety of linezolid in methicillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft tissue infection (cSSTI): a meta-analysis.
Topics: Acetamides; Aged; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Soft Tissue Infections; Staphylococcal Infections; Staphylococcal Skin Infections; Treatment Outcome; Vancomycin | 2010 |
The importance of tissue penetration in achieving successful antimicrobial treatment of nosocomial pneumonia and complicated skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus: vancomycin and linezolid.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Cross Infection; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia, Bacterial; Skin Diseases, Bacterial; Soft Tissue Infections; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2010 |
Topical non-barrier agents for postoperative adhesion prevention in animal models.
Topics: Acetamides; Antioxidants; Collagen Type I; Female; Fibrin; Glucans; Glucose; Honey; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Icodextrin; Inflammation; Linezolid; Melatonin; Oxazolidinones; Pain, Postoperative; Pelvic Pain; Pelvis; Peritoneal Diseases; Phosphatidylcholines; Postoperative Complications; Tissue Adhesions; Treatment Outcome | 2010 |
Management of methicillin-resistant Staphylococcus aureus pneumonia.
Topics: Acetamides; Anti-Bacterial Agents; Community-Acquired Infections; Cross Infection; Humans; Incidence; Infusions, Intravenous; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Vancomycin | 2010 |
Use of linezolid in pediatrics: a critical review.
Topics: Acetamides; Adolescent; Anti-Infective Agents; Child; Child, Preschool; Clinical Trials as Topic; Female; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Infant; Infant, Newborn; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Treatment Outcome | 2010 |
Clinical efficacy and tolerability of linezolid in pediatric patients: a systematic review.
Topics: Acetamides; Anti-Infective Agents; Child; Dose-Response Relationship, Drug; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Randomized Controlled Trials as Topic | 2010 |
Update in tuberculosis 2009.
Topics: Acetamides; Animals; Antitubercular Agents; Aza Compounds; Diarylquinolines; Fluoroquinolones; Humans; Linezolid; Mice; Moxifloxacin; Oxazolidinones; Quinolines; Rifampin; Tuberculosis; Tuberculosis Vaccines; Vitamin D; Vitamins | 2010 |
[Therapy of SSTI and role of tigecycline].
Topics: Acetamides; Anti-Bacterial Agents; Combined Modality Therapy; Comorbidity; Cross Infection; Daptomycin; Debridement; Drainage; Drug Therapy, Combination; Humans; Italy; Linezolid; Minocycline; Oxazolidinones; Practice Guidelines as Topic; Sepsis; Skin Diseases, Bacterial; Soft Tissue Infections; Tigecycline; Wound Infection | 2009 |
Pharmacological issues of linezolid: an updated critical review.
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Oxazolidinones; Pharmacokinetics; Protein Synthesis Inhibitors | 2010 |
Dietary tyramine restriction for hospitalized patients on linezolid: an update.
Topics: Acetamides; Diet; Drug Interactions; Guidelines as Topic; Hospitalization; Humans; Linezolid; Monoamine Oxidase Inhibitors; Oxazolidinones; Sympathomimetics; Tyramine | 2010 |
Resistance or decreased susceptibility to glycopeptides, daptomycin, and linezolid in methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Glycopeptides; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections | 2010 |
Linezolid treatment of nosocomial bacterial infection with multiresistant Gram-positive pathogens in preterm infants: a systematic review.
Topics: Acetamides; Administration, Oral; Anti-Infective Agents; Clinical Trials as Topic; Cross Infection; Drug Administration Schedule; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Injections, Intravenous; Linezolid; Oxazolidinones; United States | 2010 |
Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: a systematic review and meta-analysis.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Education, Medical, Continuing; Humans; Linezolid; Oxazolidinones; Pneumonia, Bacterial; Prospective Studies; Randomized Controlled Trials as Topic; Renal Insufficiency; Teicoplanin; Thrombocytopenia; Vancomycin | 2010 |
[Linezolid for pediatric infections].
Topics: Acetamides; Adolescent; Anti-Infective Agents; Bacterial Infections; Biological Availability; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Metabolic Clearance Rate; Microbial Sensitivity Tests; Oxazolidinones; Randomized Controlled Trials as Topic | 2010 |
[Lipopeptides and oxazolidinones--novel antibiotics in MRSA infection treatment].
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Vancomycin | 2010 |
Resistant pathogen-associated skin and skin-structure infections: antibiotic options.
Topics: Acetamides; Anti-Bacterial Agents; Carbapenems; Daptomycin; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Minocycline; Oxazolidinones; Skin Diseases, Bacterial; Tigecycline; Treatment Outcome | 2010 |
[Linezolide in paediatrics].
Topics: Acetamides; Administration, Oral; Adult; Anti-Infective Agents; Child; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Injections, Intravenous; Linezolid; Oxazolidinones | 2010 |
Methicillin-resistant Staphylococcus aureus: the superbug.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Cross Infection; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Minocycline; Oxazolidinones; Staphylococcal Infections; Tigecycline; Treatment Outcome | 2010 |
Linezolid vs glycopeptide antibiotics for the treatment of suspected methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a meta-analysis of randomized controlled trials.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Cross Infection; Glycopeptides; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Randomized Controlled Trials as Topic | 2011 |
Nosocomial methicillin-resistant Staphylococcus aureus (MRSA) pneumonia: linezolid or vancomycin? - Comparison of pharmacology and clinical efficacy.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Bacterial; Vancomycin | 2010 |
Treatment of complicated skin and soft-tissue infections caused by resistant bacteria: value of linezolid, tigecycline, daptomycin and vancomycin.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Microbial; Humans; Linezolid; Minocycline; Oxazolidinones; Skin Diseases; Soft Tissue Infections; Tigecycline; Vancomycin | 2010 |
Multiresistant bacteria and current therapy - the economical side of the story.
Topics: Acetamides; Anti-Bacterial Agents; Carbapenems; Daptomycin; Doripenem; Drug Resistance, Microbial; Drug Resistance, Multiple; Economics, Pharmaceutical; Linezolid; Minocycline; Oxazolidinones; Tigecycline | 2010 |
[Linezolid versus vancomycin in the treatment of pneumonia caused by Gram-positive cocci: meta-analysis of randomised controlled trials].
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Gram-Positive Cocci; Humans; Linezolid; Oxazolidinones; Pneumonia, Pneumococcal; Randomized Controlled Trials as Topic; Vancomycin | 2010 |
Antibiotic dosing during sustained low-efficiency dialysis: special considerations in adult critically ill patients.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Carbapenems; Critical Care; Daptomycin; Echinocandins; Fluoroquinolones; Humans; Linezolid; Oxazolidinones; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis; Renal Insufficiency; Vancomycin | 2011 |
Management of serious meticillin-resistant Staphylococcus aureus infections: what are the limits?
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Daptomycin; Endocarditis, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Pneumonia, Bacterial; Staphylococcal Infections; Teicoplanin; Tigecycline; Treatment Outcome; Vancomycin | 2011 |
Combined retrospective analysis of seven phase II and III trials of the efficacy of linezolid in the treatment of pneumonia caused by multidrug-resistant Streptococcus pneumoniae.
Topics: Acetamides; Anti-Bacterial Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Oxazolidinones; Pneumococcal Infections; Pneumonia, Bacterial; Retrospective Studies; Treatment Outcome | 2010 |
Treatment of prosthetic osteoarticular infections.
Topics: Acetamides; Anti-Bacterial Agents; Biofilms; Consensus; Daptomycin; Drug Resistance, Multiple; Humans; Interdisciplinary Communication; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Prosthesis-Related Infections; Reoperation | 2011 |
Linezolid, the first oxazolidinone antibacterial agent.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Drug Discovery; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Models, Biological; Models, Molecular; Oxazolidinones | 2011 |
Enterococcus gallinarum meningitis: a case report and literature review.
Topics: Acetamides; Anti-Bacterial Agents; Cerebrospinal Fluid; Craniotomy; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Meningitis, Bacterial; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Surgical Wound Infection; Treatment Outcome | 2011 |
[Update of antimicrobial resistance in Gram-positive microorganisms].
Topics: Acetamides; Anti-Bacterial Agents; Community-Acquired Infections; Cross Infection; Daptomycin; Drug Resistance, Microbial; Drug Resistance, Multiple, Bacterial; Enterococcus; Europe; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; United States; Vancomycin | 2010 |
Clinical activity of anti-Gram-positive agents against methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2011 |
Linezolid: safety and efficacy in special populations.
Topics: Acetamides; Anti-Bacterial Agents; Endocarditis, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Osteoarthritis; Oxazolidinones; Pneumonia, Bacterial; Skin Diseases, Bacterial; Soft Tissue Infections; Treatment Outcome; United Kingdom | 2011 |
Linezolid pharmacokinetics and pharmacodynamics in clinical treatment.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2011 |
Drug fever and DRESS syndrome.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Hypersensitivity; Drug Therapy, Combination; Eosinophilia; Exanthema; Fever; Histamine Antagonists; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Prednisolone; Syndrome; Treatment Outcome | 2011 |
Eight-year (2002-2009) summary of the linezolid (Zyvox® Annual Appraisal of Potency and Spectrum; ZAAPS) program in European countries.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Europe; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Product Surveillance, Postmarketing | 2011 |
Management of antibiotic-resistant infection in the newborn.
Topics: Acetamides; Anti-Bacterial Agents; Carbapenems; Colistin; Daptomycin; Drug Resistance, Bacterial; Gram-Negative Bacterial Infections; Humans; Infant, Newborn; Linezolid; Oxazolidinones; Vancomycin | 2011 |
Nosocomial MRSA pneumonia: data from recent clinical trials.
Topics: Acetamides; Anti-Infective Agents; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cross Infection; DNA, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Pneumonia, Ventilator-Associated; Polymerase Chain Reaction; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Vancomycin | 2011 |
Management of gram-positive bacterial infections in patients with cancer.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Lipoglycopeptides; Minocycline; Neoplasms; Oxazolidinones; Tigecycline | 2012 |
[Staphylococcus aureus and antibiotic resistance].
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Minocycline; Oxazolidinones; Protein Synthesis Inhibitors; Staphylococcal Infections; Teicoplanin; Tigecycline; Vancomycin; Vancomycin Resistance; Virginiamycin | 2011 |
Simplifying the treatment of acute bacterial bone and joint infections in children.
Topics: Acetamides; Acute Disease; Anti-Bacterial Agents; Arthritis, Infectious; Bone and Bones; C-Reactive Protein; Child; Child, Preschool; Clindamycin; Drug Administration Schedule; Finland; Humans; Joints; Kingella kingae; Linezolid; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Neisseriaceae Infections; Osteomyelitis; Oxazolidinones; Prospective Studies; Randomized Controlled Trials as Topic; Staphylococcal Infections; Vancomycin | 2011 |
The perils of not digging deep enough--uncovering a rare cause of acquired anemia.
Topics: Acetamides; Aged; Anemia, Refractory; Anemia, Sideroblastic; Anti-Bacterial Agents; Arthroplasty; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Combined Modality Therapy; Comorbidity; Diabetes Mellitus, Type 2; Diagnosis, Differential; Erythrocyte Transfusion; Erythropoietin; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Obesity, Morbid; Oxazolidinones; Polypharmacy; Postoperative Complications; Prosthesis-Related Infections; Reoperation | 2012 |
[Antibiotic dose adjustment in the treatment of MRSA infections in patients with acute renal failure undergoing continuous renal replacement therapies].
Topics: Acetamides; Acute Kidney Injury; Anti-Bacterial Agents; Drug Dosage Calculations; Glycopeptides; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Practice Guidelines as Topic; Renal Replacement Therapy; Staphylococcal Infections | 2012 |
Resistance to linezolid caused by modifications at its binding site on the ribosome.
Topics: Acetamides; Anti-Bacterial Agents; Base Sequence; Binding Sites; Drug Resistance, Bacterial; Gram-Positive Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Oxazolidinones; Ribosomes; RNA, Ribosomal, 23S | 2012 |
The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Binding Sites; Drug Resistance, Multiple, Bacterial; Erythromycin; Humans; Linezolid; Methylation; Oxazolidinones; Peptidyl Transferases; Protein Biosynthesis; Ribosomes; RNA, Ribosomal, 23S; Tetrazoles | 2012 |
Linezolid for the treatment of complicated drug-resistant tuberculosis: a systematic review and meta-analysis.
Topics: Acetamides; Antitubercular Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Oxazolidinones; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2012 |
Delayed recurrent ischemic stroke after initial good recovery from pneumococcal meningitis.
Topics: Acetamides; Brain Damage, Chronic; Brain Ischemia; Ceftriaxone; Community-Acquired Infections; Constriction, Pathologic; Dexamethasone; Disease Progression; Drug Therapy, Combination; Humans; Linezolid; Male; Meningitis, Pneumococcal; Meropenem; Middle Aged; Oxazolidinones; Platelet Aggregation Inhibitors; Prednisolone; Recurrence; Thienamycins | 2012 |
Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis.
Topics: Acetamides; Adolescent; Adult; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Patient Safety; Sputum; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2012 |
Linezolid and vancomycin in treatment of lower-extremity complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus in patients with and without vascular disease.
Topics: Acetamides; Administration, Oral; Aged; Anti-Bacterial Agents; Female; Humans; Infusions, Intravenous; Linezolid; Lower Extremity; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Randomized Controlled Trials as Topic; Staphylococcal Skin Infections; Treatment Outcome; Vancomycin; Vascular Diseases | 2012 |
Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Asia; Bone Diseases, Infectious; Doxycycline; Drug Resistance, Bacterial; Fusidic Acid; Humans; Joint Diseases; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections | 2012 |
Adverse effects of antimicrobials via predictable or idiosyncratic inhibition of host mitochondrial components.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Chloramphenicol; DNA Topoisomerases, Type I; Fluoroquinolones; Humans; Linezolid; Mitochondria; Oxazolidinones; Protein Biosynthesis; Ribosomes | 2012 |
[The cutting-edge of medicine anti-MRSA agents; how to select and how to use].
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Cross Infection; Daptomycin; Dibekacin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Vancomycin | 2012 |
[Mechanisms and epidemiology of linezolid resistance in staphylococci].
Topics: Acetamides; Drug Resistance, Bacterial; Humans; Linezolid; Oxazolidinones; Staphylococcal Infections; Staphylococcus | 2012 |
Does resistance in severe infections caused by methicillin-resistant Staphylococcus aureus give you the 'creeps'?
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Multiple, Bacterial; Glycoproteins; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Severity of Illness Index; Staphylococcal Infections; Vancomycin Resistance | 2012 |
The emerging problem of linezolid-resistant Staphylococcus.
Topics: Acetamides; Animals; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Linezolid; Oxazolidinones; Staphylococcal Infections; Staphylococcus | 2013 |
Pharmacotherapy for methicillin-resistant Staphylococcus aureus nosocomial pneumonia.
Topics: Acetamides; Anti-Bacterial Agents; Cost-Benefit Analysis; Cross Infection; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Pneumonia, Staphylococcal; Vancomycin | 2012 |
Cost-effectiveness of linezolid in methicillin-resistant Staphylococcus aureus skin and skin structure infections.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Cost-Benefit Analysis; Economics, Pharmaceutical; Health Care Costs; Hospitalization; Humans; Length of Stay; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Soft Tissue Infections; Staphylococcal Skin Infections; Vancomycin | 2012 |
How important is methicillin-resistant Staphylococcus aureus as a cause of community-acquired pneumonia and what is best antimicrobial therapy?
Topics: Acetamides; Anti-Bacterial Agents; Community-Acquired Infections; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Bacterial; Staphylococcal Infections | 2013 |
Clinical relevance of linezolid-associated serotonin toxicity.
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Oxazolidinones; Serotonin Syndrome | 2013 |
The efficacy and safety of linezolid and glycopeptides in the treatment of Staphylococcus aureus infections.
Topics: Acetamides; Anti-Bacterial Agents; Glycopeptides; Humans; Linezolid; Odds Ratio; Oxazolidinones; PubMed; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Treatment Outcome; Vancomycin | 2013 |
Linezolid versus vancomycin for meticillin-resistant Staphylococcus aureus infection: a meta-analysis of randomised controlled trials.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Kidney; Kidney Function Tests; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Randomized Controlled Trials as Topic; Staphylococcal Infections; Treatment Outcome; Vancomycin; Young Adult | 2013 |
Serotonergic and adrenergic drug interactions associated with linezolid: a critical review and practical management approach.
Topics: Acetamides; Adrenergic Agents; Drug Interactions; Humans; Linezolid; Oxazolidinones; Prospective Studies; Retrospective Studies; Serotonin Agents; Serotonin Syndrome | 2013 |
Severe infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus in infants: report of three cases and review of literature.
Topics: Acetamides; Anti-Infective Agents; Bacterial Toxins; Exotoxins; Female; Humans; Infant; Leukocidins; Linezolid; Male; Oxazolidinones; Respiratory Insufficiency; Retropharyngeal Abscess; Staphylococcal Infections; Staphylococcus aureus; Tomography, X-Ray Computed | 2013 |
Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: meta-analysis of randomised controlled trials.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Cross Infection; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia; Randomized Controlled Trials as Topic; Staphylococcal Infections; Teicoplanin; Vancomycin | 2013 |
New antibiotic agents: problems and prospects.
Topics: Acetamides; Acinetobacter; Anti-Bacterial Agents; Cross Infection; Daptomycin; Drug Resistance, Multiple, Bacterial; Humans; Ketolides; Linezolid; Methicillin-Resistant Staphylococcus aureus; Minocycline; Oxazolidinones; Pseudomonas aeruginosa; Surgical Wound Infection; Tigecycline; Vancomycin Resistance | 2005 |
Clinical management of septic arthritis.
Topics: Acetamides; Anti-Bacterial Agents; Arthritis, Infectious; Bacterial Infections; Ceftaroline; Cephalosporins; Daptomycin; Drug Therapy, Combination; Humans; Immunologic Factors; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Risk Factors; Staphylococcal Infections; Treatment Outcome; Virginiamycin | 2013 |
Subtherapeutic linezolid concentrations in a patient with morbid obesity and methicillin-resistant Staphylococcus aureus pneumonia: case report and review of the literature.
Topics: Acetamides; Adult; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Obesity, Morbid; Oxazolidinones; Pneumonia, Staphylococcal | 2013 |
WHO group 5 drugs and difficult multidrug-resistant tuberculosis: a systematic review with cohort analysis and meta-analysis.
Topics: Acetamides; Adult; Antitubercular Agents; beta-Lactams; Clofazimine; Cohort Studies; Databases, Bibliographic; Female; Fluoroquinolones; Humans; Isoniazid; Linezolid; Macrolides; Male; Oxazolidinones; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2013 |
[Guidelines for antimicrobial treatment of the infection by Staphylococcus aureus].
Topics: Acetamides; Aminoglycosides; Animals; Anti-Bacterial Agents; beta-Lactams; Clindamycin; Daptomycin; Disease Models, Animal; Fluoroquinolones; Fosfomycin; Guidelines as Topic; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Tetracyclines; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin | 2013 |
Linezolid versus vancomycin for skin and soft tissue infections.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Drug Eruptions; Humans; Length of Stay; Linezolid; Oxazolidinones; Pruritus; Randomized Controlled Trials as Topic; Skin Diseases, Bacterial; Soft Tissue Infections; Thrombocytopenia; Vancomycin | 2013 |
Treatment considerations in vancomycin-resistant enterococcal bacteremia: daptomycin or linezolid? A review.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacteremia; Daptomycin; Enterococcus; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Vancomycin Resistance | 2013 |
Systematic review and meta-analysis of linezolid and daptomycin for treatment of vancomycin-resistant enterococcal bloodstream infections.
Topics: Acetamides; Bacteremia; Daptomycin; Enterococcus; Humans; Linezolid; Oxazolidinones; Vancomycin Resistance | 2013 |
Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in surgical wounds.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Humans; Injections, Intravenous; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Randomized Controlled Trials as Topic; Staphylococcal Infections; Surgical Wound Infection; Vancomycin | 2013 |
Linezolid-induced thrombocytopenia in impaired renal function: is it time for a dose adjustment? A case report and review of literature.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Oxazolidinones; Renal Insufficiency; Thrombocytopenia | 2014 |
Systematic review and meta-analysis of linezolid versus daptomycin for treatment of vancomycin-resistant enterococcal bacteremia.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacteremia; Daptomycin; Drug Combinations; Enterococcus; Humans; Linezolid; Middle Aged; Oxazolidinones; Retrospective Studies; Survival Analysis; Treatment Outcome; Vancomycin; Vancomycin Resistance | 2014 |
[The analysis of clinical data about the treatment of linezolid against tuberculosis].
Topics: Acetamides; Animals; Antibiotics, Antitubercular; Antitubercular Agents; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Retrospective Studies; Tuberculosis, Multidrug-Resistant | 2013 |
Tedizolid for the management of human infections: in vitro characteristics.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gene Transfer, Horizontal; Humans; Linezolid; Organophosphates; Oxazoles; Oxazolidinones; Point Mutation; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus; tRNA Methyltransferases | 2014 |
Linezolid for the treatment of drug-resistant tuberculosis in children: a review and recommendations.
Topics: Acetamides; Antitubercular Agents; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Humans; Linezolid; Oxazolidinones; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2014 |
Antibiotic resistance in Enterococcus faecium clinical isolates.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Cephalosporins; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Fluoroquinolones; Genome, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Macrolides; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Penicillins | 2014 |
European perspective and update on the management of complicated skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus after more than 10 years of experience with linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Europe; Humans; Length of Stay; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Practice Guidelines as Topic; Risk Factors; Soft Tissue Infections; Staphylococcal Skin Infections | 2014 |
European perspective and update on the management of nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus after more than 10 years of experience with linezolid.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Cross Infection; Disease Models, Animal; Europe; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Pneumonia, Ventilator-Associated; Practice Guidelines as Topic; Risk Factors; Vancomycin | 2014 |
Tuberculosis: clinical trials and new drug regimens.
Topics: Acetamides; Adamantane; Antitubercular Agents; Clinical Trials as Topic; Diarylquinolines; Drug Administration Schedule; Drug Design; Ethylenediamines; Female; Fluoroquinolones; Humans; Levofloxacin; Linezolid; Male; Moxifloxacin; Nitroimidazoles; Oxazoles; Oxazolidinones; Spiro Compounds; Thiazines; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2014 |
Tedizolid: a new oxazolidinone antimicrobial.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Drug Interactions; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Tetrazoles | 2014 |
New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bone Marrow Cells; Clinical Trials, Phase I as Topic; Drug Design; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Monoamine Oxidase Inhibitors; Oxazolidinones; Pyridones; Sepsis | 2014 |
Efficacy and safety of linezolid for the treatment of infections in children: a meta-analysis.
Topics: Acetamides; Anti-Infective Agents; Child; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Randomized Controlled Trials as Topic; Staphylococcal Infections; Staphylococcus aureus; Treatment Failure; Treatment Outcome | 2014 |
Pasteurella multocida infected total knee arthroplasty: a case report and review of the literature.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Arthroplasty, Replacement, Knee; Female; Humans; Knee Prosthesis; Linezolid; Osteoarthritis, Knee; Oxazolidinones; Pasteurella Infections; Pasteurella multocida; Prosthesis-Related Infections; Salvage Therapy | 2014 |
Linezolid update: stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanisms.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Drug Approval; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Tetrazoles | 2014 |
Clinical experience with linezolid for the treatment of orthopaedic implant infections.
Topics: Acetamides; Anemia; Anti-Bacterial Agents; Drug-Related Side Effects and Adverse Reactions; Gastroenteritis; Gram-Positive Bacterial Infections; Humans; Linezolid; Osteoarthritis; Oxazolidinones; Prosthesis-Related Infections; Treatment Outcome | 2014 |
[Therapeutic Drug Monitoring of antiinfectives in intensive care medicine].
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; beta-Lactams; Biological Availability; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Fluoroquinolones; Guideline Adherence; Humans; Intensive Care Units; Linezolid; Metabolic Clearance Rate; Microbial Sensitivity Tests; Oxazolidinones; Sepsis; Shock, Septic; Teicoplanin; Vancomycin | 2014 |
What's new in the treatment of serious MRSA infection?
Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Cost-Benefit Analysis; Drug Administration Routes; Drug Therapy, Combination; Glycopeptides; Humans; Linezolid; Lipoglycopeptides; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Severity of Illness Index; Skin Diseases, Bacterial; Staphylococcal Infections; Tetrazoles; Vancomycin | 2014 |
Clinical management of Staphylococcus aureus bacteremia: a review.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacteremia; Daptomycin; Drug Therapy, Combination; Echocardiography, Transesophageal; Endocarditis, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin | 2014 |
[Antibiotics for treatment of infections by methicillin-resistant Staphylococcus aureus (MRSA)].
Topics: Acetamides; Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Evidence-Based Medicine; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Treatment Outcome; Vancomycin | 2014 |
Optimizing therapy for vancomycin-resistant enterococcal bacteremia in children.
Topics: Acetamides; Adolescent; Child; Child, Preschool; Daptomycin; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Risk Factors; Treatment Outcome; Vancomycin; Vancomycin-Resistant Enterococci; Virginiamycin | 2014 |
Vancomycin-resistant enterococcal bacteremia pharmacotherapy.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Daptomycin; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Vancomycin; Vancomycin-Resistant Enterococci; Virginiamycin | 2015 |
Linezolid versus vancomycin for the treatment of suspected methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a systematic review employing meta-analysis.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia; Randomized Controlled Trials as Topic; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2015 |
Daptomycin versus linezolid for treatment of vancomycin-resistant enterococcal bacteremia: systematic review and meta-analysis.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Daptomycin; Humans; Linezolid; Oxazolidinones; Retrospective Studies; Treatment Outcome; Vancomycin; Vancomycin Resistance; Vancomycin-Resistant Enterococci | 2014 |
Panton-Valentine leukocidin positive Staphylococcal aureus infections of the head and neck: case series and brief review of literature.
Topics: Abscess; Acetamides; Adolescent; Adult; Anti-Bacterial Agents; Bacterial Toxins; Cellulitis; Dental Caries; Exotoxins; Face; Fatal Outcome; Female; Humans; Leukocidins; Linezolid; Lip Diseases; Lung Abscess; Male; Neck; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2015 |
[Treatment options for serious infections caused by vancomycin-resistant enterococci].
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Enterobacteriaceae; Evidence-Based Medicine; Gram-Positive Bacterial Infections; Humans; Linezolid; Minocycline; Oxazolidinones; Tigecycline; Treatment Outcome; Vancomycin-Resistant Enterococci | 2015 |
Antibiotic management of methicillin-resistant Staphylococcus aureus--associated acute pulmonary exacerbations in cystic fibrosis.
Topics: Acetamides; Anti-Bacterial Agents; Cystic Fibrosis; Humans; Linezolid; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Vancomycin | 2015 |
What is the best therapeutic approach to methicillin-resistant Staphylococcus aureus pneumonia?
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Treatment Outcome; Vancomycin | 2015 |
Drug-drug interactions and safety of linezolid, tedizolid, and other oxazolidinones.
Topics: Animals; Anti-Bacterial Agents; Drug Interactions; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Organophosphates; Oxazoles; Oxazolidinones; Structure-Activity Relationship | 2015 |
Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Linezolid; Oxazolidinones; Precision Medicine; Tetrazoles | 2016 |
Acute bacterial skin and skin structure infections in internal medicine wards: old and new drugs.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Carbapenems; Ceftaroline; Cephalosporins; Daptomycin; Female; Fluoroquinolones; Glycopeptides; Hospitalization; Humans; Iatrogenic Disease; Internal Medicine; Linezolid; Lipoglycopeptides; Male; Minocycline; Oxazolidinones; Skin Diseases, Infectious; Soft Tissue Infections; Teicoplanin; Tigecycline; Vancomycin | 2016 |
Group 5 drugs for multidrug-resistant tuberculosis: individual patient data meta-analysis.
Topics: Adult; Amoxicillin; Antitubercular Agents; Clofazimine; Cohort Studies; Drug Therapy, Combination; Female; Humans; Isoxazoles; Linezolid; Logistic Models; Macrolides; Male; Microbial Sensitivity Tests; Middle Aged; Multivariate Analysis; Oxazolidinones; Thioacetazone; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Young Adult | 2017 |
Systematic review and network meta-analysis of tedizolid for the treatment of acute bacterial skin and skin structure infections caused by MRSA.
Topics: Anti-Bacterial Agents; Bayes Theorem; Ceftaroline; Cephalosporins; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; Staphylococcal Infections; Tetrazoles; Vancomycin | 2017 |
An evaluation of tedizolid for the treatment of MRSA infections.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Randomized Controlled Trials as Topic; Soft Tissue Infections; Staphylococcal Infections; Tetrazoles | 2018 |
[Enterococci With Special Resistance Patterns - Epidemiology, Hygiene and Therapy].
Topics: Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Lipoglycopeptides; Oxazolidinones; Tetrazoles; Tigecycline; Vancomycin Resistance | 2019 |
[Linezolid-induced lactic acidosis - a brief overview with a case report].
Topics: Acidosis, Lactic; Aged; Anti-Bacterial Agents; Humans; Linezolid; Male; Osteomyelitis; Oxazolidinones; Sepsis; Staphylococcal Infections; Treatment Outcome | 2019 |
Tedizolid (torezolid) for the treatment of complicated skin and skin structure infections.
Topics: Animals; Anti-Bacterial Agents; Drug Interactions; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Skin Diseases, Bacterial; Staphylococcal Infections; Tetrazoles | 2020 |
Meta-analysis of vancomycin versus linezolid in pneumonia with proven methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia; Randomized Controlled Trials as Topic; Vancomycin | 2021 |
Oxazolidinones: mechanisms of resistance and mobile genetic elements involved.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; DNA, Ribosomal; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Interspersed Repetitive Sequences; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Peptidyl Transferases; Ribosomal Proteins | 2022 |
Biologically Active 2-Oxazolidinone Derivatives Beyond Antibacterial Activities.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Oxindoles | 2023 |
Oxazolidinone: A promising scaffold for the development of antibacterial drugs.
Topics: Anti-Bacterial Agents; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Structure-Activity Relationship | 2023 |
Strategies for the Discovery of Oxazolidinone Antibacterial Agents: Development and Future Perspectives.
Topics: Anti-Bacterial Agents; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Protein Synthesis Inhibitors | 2023 |
163 trial(s) available for oxazolidin-2-one and linezolid
| Article | Year |
|---|---|
Serum inhibitory titers and serum bactericidal titers for human subjects receiving multiple doses of the antibacterial oxazolidinones eperezolid and linezolid.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Injections, Intravenous; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Pneumococcal Infections; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae | 1997 |
A pharmacokinetic evaluation of concomitant administration of linezolid and aztreonam.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Aztreonam; Cross-Over Studies; Drug Interactions; Female; Humans; Linezolid; Male; Middle Aged; Monobactams; Oxazoles; Oxazolidinones | 1999 |
Use of linezolid, an oxazolidinone, in the treatment of multidrug-resistant gram-positive bacterial infections.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Microbial; Drug Resistance, Multiple; Enterococcus; Epidural Abscess; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Oxazoles; Oxazolidinones; Parotitis; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance | 2000 |
Randomized comparison of linezolid (PNU-100766) versus oxacillin-dicloxacillin for treatment of complicated skin and soft tissue infections.
Topics: Acetamides; Anti-Infective Agents; Dicloxacillin; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Linezolid; Male; Middle Aged; Oxacillin; Oxazolidinones; Penicillins; Skin Diseases, Bacterial; Soft Tissue Infections; Treatment Outcome | 2000 |
Single dose pharmacokinetics of linezolid in infants and children.
Topics: Acetamides; Adolescent; Anti-Infective Agents; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Linezolid; Mass Spectrometry; Oxazolidinones | 2000 |
Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aztreonam; Cross Infection; Double-Blind Method; Drug Resistance, Microbial; Drug Therapy, Combination; Gram-Positive Bacteria; Hospitalization; Humans; Linezolid; Male; Middle Aged; Monobactams; Oxazolidinones; Pneumonia; Safety; Time Factors; Treatment Outcome; Vancomycin | 2001 |
Comparison of length of hospital stay for patients with known or suspected methicillin-resistant Staphylococcus species infections treated with linezolid or vancomycin: a randomized, multicenter trial.
Topics: Acetamides; Administration, Oral; Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Female; Humans; Injections, Intravenous; Length of Stay; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2001 |
Linezolid, a novel oxazolidinone antibiotic: assessment of monoamine oxidase inhibition using pressor response to oral tyramine.
Topics: Acetamides; Administration, Oral; Adult; Analysis of Variance; Anti-Infective Agents; Area Under Curve; Blood Pressure; Catecholamines; Dose-Response Relationship, Drug; Heart Rate; Humans; Linezolid; Male; Metabolic Clearance Rate; Moclobemide; Monoamine Oxidase Inhibitors; Oxazolidinones; Tyramine | 2001 |
Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr.
Topics: Acetamides; Adult; Area Under Curve; Blood Pressure; Body Temperature; Dextromethorphan; Dizziness; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Ephedrine; Female; Headache; Heart Rate; Humans; Linezolid; Male; Mental Processes; Middle Aged; Monoamine Oxidase Inhibitors; Nonprescription Drugs; Oxazolidinones; Phenylpropanolamine; Regression Analysis; Sympathomimetics | 2001 |
Linezolid for the treatment of community-acquired pneumonia in hospitalized children. Linezolid Pediatric Pneumonia Study Group.
Topics: Acetamides; Adolescent; Anti-Infective Agents; Child; Child, Preschool; Community-Acquired Infections; Drug Resistance, Microbial; Female; Hospitalization; Humans; Infant; Linezolid; Male; Oxazolidinones; Pneumonia, Bacterial; Time Factors | 2001 |
Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [(14)C]linezolid to healthy human subjects.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Biotransformation; Chromatography, High Pressure Liquid; Feces; Female; Fluorine Radioisotopes; Half-Life; Humans; Isotope Labeling; Linezolid; Male; Mass Spectrometry; Middle Aged; Oxazolidinones; Spectrophotometry, Ultraviolet; Whole-Body Counting | 2001 |
Linezolid absolute bioavailability and the effect of food on oral bioavailability.
Topics: Acetamides; Administration, Oral; Adult; Analysis of Variance; Anti-Bacterial Agents; Biological Availability; Cross-Over Studies; Dietary Fats; Fasting; Female; Food-Drug Interactions; Humans; Injections, Intravenous; Linezolid; Male; Middle Aged; Oxazolidinones | 2001 |
Approaches to analysis of length of hospital stay related to antibiotic therapy in a randomized clinical trial: linezolid versus vancomycin for treatment of known or suspected methicillin-resistant Staphylococcus species infections.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Clinical Trials, Phase III as Topic; Costs and Cost Analysis; Female; Health Care Costs; Humans; Length of Stay; Linezolid; Male; Methicillin Resistance; Middle Aged; Models, Statistical; Multicenter Studies as Topic; Oxazolidinones; Randomized Controlled Trials as Topic; Retrospective Studies; Staphylococcal Infections; Time Factors; Vancomycin | 2002 |
Cerebrospinal fluid linezolid concentrations in postneurosurgical central nervous system infections.
Topics: Acetamides; Anti-Infective Agents; Antibiotic Prophylaxis; Central Nervous System Infections; Humans; Linezolid; Meningitis, Bacterial; Oxazolidinones; Postoperative Complications | 2002 |
Ecological effects of linezolid versus amoxicillin/clavulanic acid on the normal intestinal microflora.
Topics: Acetamides; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Aerobic; Cross-Over Studies; Drug Therapy, Combination; Feces; Female; Humans; Intestines; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones | 2001 |
Age and sex effects on the pharmacokinetics of linezolid.
Topics: Acetamides; Adult; Aging; Anti-Infective Agents; Area Under Curve; Body Mass Index; Chromatography, High Pressure Liquid; Creatinine; Female; Half-Life; Humans; Kidney Function Tests; Linezolid; Male; Oxazolidinones; Sex Characteristics | 2002 |
Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections.
Topics: Acetamides; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin | 2002 |
[Comparison of linezolid and vancomycin in nosocomial pneumonia: results of the multicenter double-blind study].
Topics: Acetamides; Adolescent; Adult; Anti-Bacterial Agents; Bacteria; Cross Infection; Double-Blind Method; Drug Resistance, Bacterial; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pneumonia, Bacterial | 2002 |
Effects of linezolid on hospital length of stay compared with vancomycin in treatment of methicillin-resistant Staphylococcus infections. An application of multivariate survival analysis.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Drug Administration Routes; Hospitalization; Humans; Length of Stay; Linezolid; Methicillin Resistance; Middle Aged; Multivariate Analysis; Oxazolidinones; Proportional Hazards Models; Staphylococcal Infections; Staphylococcus; Survival Analysis; Treatment Outcome; Vancomycin | 2002 |
Single- and multiple-dose pharmacokinetics of linezolid and co-amoxiclav in healthy human volunteers.
Topics: Acetamides; Adult; Amoxicillin-Potassium Clavulanate Combination; Area Under Curve; Cross-Over Studies; Drug Administration Schedule; Female; Humans; Linezolid; Male; Oxazolidinones; Sex Factors; Statistics, Nonparametric | 2002 |
Linezolid versus ceftriaxone/cefpodoxime in patients hospitalized for the treatment of Streptococcus pneumoniae pneumonia.
Topics: Acetamides; Administration, Oral; Adolescent; Adult; Aged; Cefpodoxime; Ceftizoxime; Ceftriaxone; Community-Acquired Infections; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Hospitalization; Humans; Infusions, Intravenous; Italy; Linezolid; Logistic Models; Male; Middle Aged; Oxazolidinones; Pneumonia, Pneumococcal; Probability; Streptococcus pneumoniae; Treatment Outcome | 2002 |
Linezolid for the treatment of multidrug-resistant, gram-positive infections: experience from a compassionate-use program.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Infective Agents; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Multiple; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Treatment Outcome | 2003 |
Clinical experience with linezolid for the treatment of nocardia infection.
Topics: Acetamides; Anti-Bacterial Agents; Child; Female; Humans; Linezolid; Male; Middle Aged; Nocardia; Nocardia Infections; Oxazolidinones; Treatment Outcome | 2003 |
Population pharmacokinetics of linezolid in patients treated in a compassionate-use program.
Topics: Acetamides; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Area Under Curve; Bacterial Infections; Biological Availability; Female; Half-Life; Humans; Injections, Intravenous; Linezolid; Male; Metabolic Clearance Rate; Middle Aged; Oxazolidinones | 2003 |
[The first clinical experiences in Hungary with a new effective antibiotic (linezolid) effective against Gram-positive infections].
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Gram-Positive Bacterial Infections; Humans; International Cooperation; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Treatment Outcome | 2003 |
Pharmacokinetics and tolerance of single- and multiple-dose oral or intravenous linezolid, an oxazolidinone antibiotic, in healthy volunteers.
Topics: Acetamides; Administration, Oral; Adolescent; Adult; Algorithms; Anti-Infective Agents; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Intravenous; Linezolid; Male; Middle Aged; Oxazolidinones | 2003 |
Linezolid versus cefadroxil in the treatment of skin and skin structure infections in children.
Topics: Acetamides; Administration, Oral; Adolescent; Cefadroxil; Child; Child, Preschool; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Oxazolidinones; Probability; Prospective Studies; Reference Values; Risk Assessment; Single-Blind Method; Skin Diseases, Infectious; Treatment Outcome | 2003 |
Effect of linezolid versus vancomycin on length of hospital stay in patients with complicated skin and soft tissue infections caused by known or suspected methicillin-resistant staphylococci: results from a randomized clinical trial.
Topics: Acetamides; Administration, Oral; Aged; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Length of Stay; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Probability; Prognosis; Severity of Illness Index; Skin Diseases, Bacterial; Staphylococcus aureus; Treatment Outcome; Vancomycin; Wound Infection | 2003 |
Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Aztreonam; Cross Infection; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pneumonia, Bacterial; Vancomycin | 2003 |
Hospital resource use and cost of treatment with linezolid versus teicoplanin for treatment of serious gram-positive bacterial infections among hospitalized patients from South America and Mexico: results from a multicenter trial.
Topics: Acetamides; Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Female; Gram-Positive Bacterial Infections; Hospital Costs; Humans; Injections, Intramuscular; Injections, Intravenous; Linezolid; Male; Mexico; Middle Aged; Oxazolidinones; South America; Teicoplanin | 2003 |
Linezolid versus vancomycin for treatment of resistant Gram-positive infections in children.
Topics: Acetamides; Bacteremia; Child; Child, Preschool; Confidence Intervals; Cross Infection; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Multiple; Female; Follow-Up Studies; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Latin America; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Probability; Severity of Illness Index; Treatment Outcome; United States; Vancomycin | 2003 |
Pharmacokinetics of linezolid in subjects with renal dysfunction.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Creatinine; Female; Humans; Kidney Diseases; Kidney Failure, Chronic; Kidney Function Tests; Linezolid; Male; Middle Aged; Oxazolidinones; Renal Dialysis | 2003 |
The pharmacokinetics of linezolid are not affected by concomitant intake of the antioxidant vitamins C and E.
Topics: Acetamides; Administration, Oral; Adult; Ascorbic Acid; Diet; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Humans; Linezolid; Male; Oxazolidinones; Reactive Oxygen Species; Vitamin E | 2003 |
Linezolid versus vancomycin in the treatment of known or suspected resistant gram-positive infections in neonates.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents; Female; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infusions, Intravenous; Linezolid; Male; Oxazolidinones; Treatment Outcome; Vancomycin | 2003 |
Linezolid for the treatment of children with bacteremia or nosocomial pneumonia caused by resistant gram-positive bacterial pathogens.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Child; Child, Preschool; Cross Infection; Drug Resistance, Microbial; Female; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Linezolid; Male; Oxazolidinones; Pneumonia, Bacterial; Treatment Outcome; Vancomycin | 2003 |
Linezolid for the treatment of complicated skin and skin structure infections in children.
Topics: Acetamides; Administration, Oral; Age Factors; Anti-Bacterial Agents; Anti-Infective Agents; Child; Child, Preschool; Female; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Linezolid; Male; Oxazolidinones; Skin Diseases, Bacterial; Treatment Outcome; Vancomycin | 2003 |
Linezolid for the treatment of methicillin-resistant Staphylococcus aureus infections in children.
Topics: Acetamides; Administration, Oral; Adolescent; Anti-Bacterial Agents; Cefadroxil; Child; Child, Preschool; Double-Blind Method; Female; Humans; Infusions, Intravenous; Linezolid; Male; Methicillin Resistance; Outpatients; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2003 |
Hematologic effects of linezolid in young children.
Topics: Acetamides; Administration, Oral; Age Factors; Anemia; Anti-Bacterial Agents; Anti-Infective Agents; Child; Child, Preschool; Female; Gram-Positive Bacterial Infections; Hemoglobins; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Linezolid; Male; Neutropenia; Oxazolidinones; Thrombocytopenia; Vancomycin | 2003 |
Safety and tolerability of linezolid in children.
Topics: Acetamides; Administration, Oral; Adolescent; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Cefadroxil; Child; Child, Preschool; Community-Acquired Infections; Cross Infection; Diarrhea; Female; Gram-Positive Bacterial Infections; Headache; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Linezolid; Male; Multicenter Studies as Topic; Otitis Media; Oxazolidinones; Pneumonia; Randomized Controlled Trials as Topic; Respiratory Tract Infections; Skin Diseases, Bacterial | 2003 |
Resistance of gram-positive pathogens to antibiotics is a therapeutic challenge after liver transplantation: clinical experience in one center with linezolid.
Topics: Acetamides; Adult; Anti-Infective Agents; Female; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Humans; Linezolid; Liver Transplantation; Male; Methicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Postoperative Complications; Staphylococcal Infections; Staphylococcus aureus | 2003 |
Cytokines in periradicular lesions: the effect of linezolid treatment.
Topics: Acetamides; Adult; Aged; Analysis of Variance; Anti-Infective Agents; Bacteria, Anaerobic; Cytokines; Dental Restoration Failure; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-6; Linezolid; Male; Middle Aged; Oxazolidinones; Periapical Periodontitis; Receptors, Interleukin-1; Root Canal Therapy; Sialoglycoproteins; Transforming Growth Factor beta | 2003 |
Impact of ontogeny on linezolid disposition in neonates and infants.
Topics: Acetamides; Aging; Anti-Infective Agents; Area Under Curve; Chromatography, High Pressure Liquid; Female; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Linezolid; Male; Oxazolidinones | 2003 |
Linezolid in the treatment of vancomycin-resistant Enterococcus faecium in solid organ transplant recipients: report of a multicenter compassionate-use trial.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Infective Agents; Child; Child, Preschool; Empathy; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Organ Transplantation; Oxazolidinones; Treatment Outcome; Vancomycin Resistance | 2003 |
Concentrations in plasma, urinary excretion, and bactericidal activity of linezolid (600 milligrams) versus those of ciprofloxacin (500 milligrams) in healthy volunteers receiving a single oral dose.
Topics: Acetamides; Adult; Anti-Infective Agents; Area Under Curve; Bacteria; Calibration; Cephalosporins; Ciprofloxacin; Cross-Over Studies; Double-Blind Method; Female; Half-Life; Humans; Hydrogen-Ion Concentration; Linezolid; Male; Oxazolidinones; Quality Control; Serum Bactericidal Test | 2003 |
Linezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Bone and Bones; Debridement; Female; Humans; Joints; Linezolid; Male; Methicillin Resistance; Middle Aged; Necrosis; Oxazolidinones; Staphylococcal Infections | 2003 |
Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampicillin-sulbactam/amoxicillin-clavulanate.
Topics: Acetamides; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Diabetes Complications; Drug Therapy, Combination; Foot Diseases; Humans; Linezolid; Oxazolidinones; Sulbactam; Treatment Outcome | 2004 |
Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: comparative analysis of linezolid and vancomycin use.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Cross Infection; Double-Blind Method; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pneumonia, Bacterial; Prospective Studies; Thrombocytopenia; Vancomycin | 2003 |
Linezolid pharmacokinetics in adult patients with cystic fibrosis.
Topics: Acetamides; Adult; Anti-Infective Agents; Area Under Curve; Chromatography, High Pressure Liquid; Cystic Fibrosis; Female; Humans; Linezolid; Male; Oxazolidinones; Spectrophotometry, Ultraviolet | 2004 |
Linezolid versus teicoplanin in the treatment of Gram-positive infections in the critically ill: a randomized, double-blind, multicentre study.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Arthritis, Infectious; Critical Care; Critical Illness; Cross Infection; Double-Blind Method; Drug Resistance, Bacterial; Female; Gram-Positive Bacterial Infections; Humans; Injections, Intravenous; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones; Pneumonia, Bacterial; Respiratory Tract Infections; Sepsis; Soft Tissue Infections; Teicoplanin; Treatment Outcome | 2004 |
[Linezolid for the treatment of nosocomial infections after cardiac surgery].
Topics: Acetamides; Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Cardiac Surgical Procedures; Child; Child, Preschool; Cross Infection; Drug Therapy, Combination; Endocarditis, Bacterial; Humans; Infant; Injections, Intravenous; Linezolid; Methicillin Resistance; Middle Aged; Oxazolidinones; Pneumonia; Postoperative Complications; Staphylococcus; Surgical Wound Infection; Treatment Outcome | 2003 |
Serum and sputum concentrations following the oral administration of linezolid in adult patients with cystic fibrosis.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Cystic Fibrosis; Female; Humans; Linezolid; Male; Oxazolidinones; Pancreatic Diseases; Prospective Studies; Sputum | 2004 |
Linezolid compared with teicoplanin for the treatment of suspected or proven Gram-positive infections.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Costs and Cost Analysis; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Teicoplanin | 2004 |
Penetration of linezolid into the anterior chamber (aqueous humor) of the human eye after intravenous administration.
Topics: Acetamides; Aged; Anti-Infective Agents; Aqueous Humor; Cataract Extraction; Female; Humans; Infusions, Intravenous; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Staphylococcus epidermidis | 2004 |
Short-course treatment regimen to identify potential antituberculous agents in a murine model of tuberculosis.
Topics: Acetamides; Animals; Antitubercular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Fluoroquinolones; Gatifloxacin; Isoniazid; Linezolid; Mice; Mice, Inbred C57BL; Oxazolidinones; Rifampin; Time Factors; Tuberculosis | 2004 |
Prospective, randomized study comparing quinupristin-dalfopristin with linezolid in the treatment of vancomycin-resistant Enterococcus faecium infections.
Topics: Acetamides; Adult; Aged; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Pilot Projects; Prospective Studies; Vancomycin Resistance; Virginiamycin | 2004 |
Linezolid in the treatment of osteomyelitis: results of compassionate use experience.
Topics: Acetamides; Administration, Oral; Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Bacterial; Female; Follow-Up Studies; Gram-Positive Bacterial Infections; Humans; Injections, Intravenous; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones; Prospective Studies; Risk Assessment; Severity of Illness Index; Single-Blind Method; Treatment Outcome | 2004 |
An economic evaluation of a European cohort from a multinational trial of linezolid versus teicoplanin in serious Gram-positive bacterial infections: the importance of treatment setting in evaluating treatment effects.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Infective Agents; Cohort Studies; Costs and Cost Analysis; Europe; Female; Gram-Positive Bacterial Infections; Hospitalization; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Teicoplanin | 2004 |
Aqueous and vitreous penetration of linezolid (Zyvox) after oral administration.
Topics: Acetamides; Administration, Oral; Anti-Infective Agents; Aqueous Humor; Biological Availability; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Prospective Studies; Protein Synthesis Inhibitors; Vitrectomy; Vitreous Body | 2004 |
Efficacy and tolerability of linezolid in treating severe skin and soft tissue infections caused by Gram-positive pathogens.
Topics: Acetamides; Cellulitis; Consumer Product Safety; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Protein Synthesis Inhibitors; Skin Diseases, Bacterial; Soft Tissue Infections | 2004 |
Effect of oral linezolid on the pressor response to intravenous tyramine.
Topics: Acetamides; Administration, Oral; Adult; Blood Pressure; Body Mass Index; Cross-Over Studies; Humans; Infusions, Intravenous; Linezolid; Male; Middle Aged; Moclobemide; Monoamine Oxidase Inhibitors; Oxazolidinones; Tyramine | 2004 |
Successful treatment of chronic bone and joint infections with oral linezolid.
Topics: Acetamides; Administration, Oral; Adult; Aged; Anti-Infective Agents; Chronic Disease; Female; Follow-Up Studies; Humans; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones; Prospective Studies; Prosthesis-Related Infections; Remission Induction | 2004 |
Linezolid eradicates MRSA better than vancomycin from surgical-site infections.
Topics: Acetamides; Adult; Aged; Analysis of Variance; Chi-Square Distribution; Female; Follow-Up Studies; Humans; International Cooperation; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Probability; Risk Assessment; Severity of Illness Index; Single-Blind Method; Staphylococcal Infections; Staphylococcus aureus; Surgical Wound Infection; Treatment Outcome; Vancomycin; Wound Healing | 2004 |
Pharmacokinetics and pharmacodynamics of linezolid in obese patients with cellulitis.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Area Under Curve; Cellulitis; Drug Resistance, Multiple, Bacterial; Female; Half-Life; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Obesity; Oxazolidinones; Serum Bactericidal Test; Skin Diseases, Bacterial; Soft Tissue Infections | 2005 |
Pharmacokinetic studies of linezolid and teicoplanin in the critically ill.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Area Under Curve; Critical Illness; Double-Blind Method; Female; Humans; Linezolid; Male; Middle Aged; Models, Biological; Oxazolidinones; Prospective Studies; Teicoplanin | 2005 |
Clinical and economic outcomes of oral linezolid versus intravenous vancomycin in the treatment of MRSA-complicated, lower-extremity skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Administration, Oral; Adult; Aged; Cost-Benefit Analysis; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Linezolid; Lower Extremity; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Probability; Reference Values; Severity of Illness Index; Single-Blind Method; Skin Diseases, Infectious; Soft Tissue Infections; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; United States; Vancomycin | 2005 |
Linezolid versus vancomycin in treatment of complicated skin and soft tissue infections.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Female; Humans; Internationality; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Skin Diseases, Bacterial; Soft Tissue Infections; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin | 2005 |
Absolute bioavailability and pharmacokinetics of linezolid in hospitalized patients given enteral feedings.
Topics: Acetamides; Aged; Anti-Infective Agents; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Enteral Nutrition; Female; Half-Life; Humans; Linezolid; Male; Middle Aged; Nonlinear Dynamics; Oxazolidinones; Prospective Studies | 2005 |
Randomized, double-blind comparison of once-weekly dalbavancin versus twice-daily linezolid therapy for the treatment of complicated skin and skin structure infections.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Double-Blind Method; Drug Administration Schedule; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Skin Diseases, Bacterial; Teicoplanin; Time Factors | 2005 |
Linezolid reduces length of stay and duration of intravenous treatment compared with vancomycin for complicated skin and soft tissue infections due to suspected or proven methicillin-resistant Staphylococcus aureus (MRSA).
Topics: Acetamides; Administration, Oral; Adolescent; Adult; Aged; Americas; Anti-Bacterial Agents; Anti-Infective Agents; Asia; Europe; Female; Humans; Injections, Intravenous; Length of Stay; Linezolid; Male; Methicillin; Methicillin Resistance; Middle Aged; New Zealand; Oxazolidinones; Soft Tissue Infections; Staphylococcal Infections; Staphylococcal Skin Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin | 2005 |
[Problems of prophylaxis and treatment of infectious complications in reconstructive surgery].
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Female; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Plastic Surgery Procedures; Surgical Wound Infection | 2005 |
Lack of pharmacokinetic interaction between linezolid and antacid in healthy volunteers.
Topics: Acetamides; Administration, Oral; Adult; Aluminum Hydroxide; Antacids; Area Under Curve; Cross-Over Studies; Drug Combinations; Drug Interactions; Female; Humans; Linezolid; Magnesium Hydroxide; Male; Middle Aged; Oxazolidinones; Sex Factors; Volunteers | 2006 |
Efficacy and safety of linezolid compared with vancomycin in a randomized, double-blind study of febrile neutropenic patients with cancer.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Double-Blind Method; Female; Fever; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Neoplasms; Neutropenia; Oxazolidinones; Vancomycin | 2006 |
Impact of linezolid on economic outcomes and determinants of cost in a clinical trial evaluating patients with MRSA complicated skin and soft-tissue infections.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Aztreonam; Clinical Trials as Topic; Cost-Benefit Analysis; Delivery of Health Care; Drug Costs; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Prospective Studies; Regression Analysis; Skin Diseases, Infectious; Streptococcal Infections; Treatment Outcome; Vancomycin | 2006 |
Efficacy and tolerability of daily-half dose linezolid in patients with intractable multidrug-resistant tuberculosis.
Topics: Acetamides; Adolescent; Adult; Antitubercular Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Humans; Linezolid; Male; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Treatment Outcome; Tuberculosis, Pulmonary | 2006 |
Serum and cerebrospinal fluid concentrations of linezolid in neurosurgical patients.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Area Under Curve; Bacterial Infections; Brain Diseases; Chromatography, High Pressure Liquid; Critical Illness; Female; Gram-Positive Bacteria; Half-Life; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Neurosurgical Procedures; Oxazolidinones; Prospective Studies | 2006 |
No effect of pyridoxine on the incidence of myelosuppression during prolonged linezolid treatment.
Topics: Acetamides; Anemia; Anti-Bacterial Agents; Female; Humans; Incidence; Linezolid; Male; Middle Aged; Oxazolidinones; Pyridoxine; Thrombocytopenia | 2006 |
Pharmacokinetics of intravenous linezolid in cerebrospinal fluid and plasma in neurointensive care patients with staphylococcal ventriculitis associated with external ventricular drains.
Topics: Acetamides; Adolescent; Adult; Aged; Area Under Curve; Cerebral Ventricles; Encephalitis; Female; Humans; Injections, Intravenous; Linezolid; Male; Metabolic Clearance Rate; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus | 2007 |
Cost-effectiveness of linezolid and vancomycin in the treatment of surgical site infections.
Topics: Acetamides; Anti-Infective Agents; Cost-Benefit Analysis; Decision Trees; Female; Hospitalization; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Retrospective Studies; Staphylococcal Infections; Surgical Wound Infection; Treatment Outcome; Vancomycin | 2007 |
Larval therapy: a novel treatment in eliminating methicillin-resistant Staphylococcus aureus from diabetic foot ulcers.
Topics: Acetamides; Aged; Animals; Diabetic Foot; Diabetic Neuropathies; Foot Ulcer; Humans; Larva; Linezolid; Methicillin Resistance; Middle Aged; Oxazolidinones; Patient Selection; Reproducibility of Results; Staphylococcus aureus; Vancomycin | 2007 |
Haematological safety of long-term therapy with linezolid.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Drug-Related Side Effects and Adverse Reactions; Female; Hematologic Diseases; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Prospective Studies; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Thrombocytopenia | 2007 |
Penetration of linezolid into sternal bone of patients undergoing cardiopulmonary bypass surgery.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Cardiopulmonary Bypass; Female; Humans; Infusions, Intravenous; Linezolid; Male; Osteomyelitis; Oxazolidinones; Sternum | 2007 |
Efficacy and tolerability of prolonged linezolid therapy in the treatment of orthopedic implant infections.
Topics: Acetamides; Administration, Oral; Aged; Anti-Infective Agents; Female; Humans; Joint Prosthesis; Linezolid; Male; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Treatment Outcome | 2007 |
Does linezolid inhibit its own metabolism? Population pharmacokinetics as a tool to explain the observed nonlinearity in both healthy volunteers and septic patients.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Models, Biological; Oxazolidinones; Protein Synthesis Inhibitors; Sepsis | 2007 |
Treatment of orthopedic infections caused by resistant staphylococci.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Female; Humans; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Osteomyelitis; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2007 |
Linezolid versus vancomycin for the treatment of infections caused by methicillin-resistant Staphylococcus aureus in Japan.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Humans; Japan; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2007 |
Effect of severity of sepsis on tissue concentrations of linezolid.
Topics: Acetamides; Adipose Tissue; Administration, Oral; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Linezolid; Microdialysis; Muscle, Skeletal; Oxazolidinones; Sepsis; Severity of Illness Index; Tissue Distribution | 2008 |
Linezolid pharmacokinetic/pharmacodynamic profile in critically ill septic patients: intermittent versus continuous infusion.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Critical Illness; Drug Administration Schedule; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Infusions, Intravenous; Injections, Intravenous; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Sepsis | 2008 |
Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicity.
Topics: Acetamides; Anti-Bacterial Agents; Cohort Studies; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Incidence; Kidney; Kidney Diseases; Linezolid; Male; Middle Aged; Oxazolidinones; Vancomycin | 2008 |
Linezolid for the treatment of infections caused by Gram-positive pathogens in China.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; China; Cross Infection; Double-Blind Method; Female; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pneumonia, Bacterial; Skin Diseases, Bacterial; Soft Tissue Infections; Treatment Outcome; Vancomycin | 2008 |
Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a Phase 3, multicentre, double-blind, randomized study.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Cross Infection; Double-Blind Method; Enterococcus; Female; Gram-Positive Bacterial Infections; Hospitalization; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Minocycline; Oxazolidinones; Staphylococcus aureus; Tigecycline; Treatment Outcome; Vancomycin; Vancomycin Resistance | 2008 |
Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Bronchoalveolar Lavage Fluid; Female; Follow-Up Studies; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Pneumonia, Ventilator-Associated; Prospective Studies; Staphylococcal Infections; Time Factors; Treatment Outcome; Vancomycin | 2008 |
Early and extended early bactericidal activity of linezolid in pulmonary tuberculosis.
Topics: Acetamides; Adult; Antibiotics, Antitubercular; Colony Count, Microbial; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Isoniazid; Linezolid; Male; Middle Aged; Oxazolidinones; Sputum; Tuberculosis, Pulmonary; Young Adult | 2008 |
Complicated skin and skin-structure infections and catheter-related bloodstream infections: noninferiority of linezolid in a phase 3 study.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Catheter-Related Infections; Cross Infection; Female; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Skin Diseases, Bacterial; Vancomycin | 2009 |
Efficacy and tolerance of rifampicin-linezolid compared with rifampicin-cotrimoxazole combinations in prolonged oral therapy for bone and joint infections.
Topics: Acetamides; Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Chronic Disease; Drug Therapy, Combination; Female; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Male; Middle Aged; Orthotic Devices; Osteomyelitis; Oxazolidinones; Prosthesis-Related Infections; Rifampin; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination; Young Adult | 2009 |
Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis.
Topics: Acetamides; Adolescent; Adult; Anti-Bacterial Agents; Drug Administration Schedule; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Tuberculosis, Pulmonary; Young Adult | 2009 |
Salvage treatment for persistent methicillin-resistant Staphylococcus aureus bacteremia: efficacy of linezolid with or without carbapenem.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Aminoglycosides; Anti-Bacterial Agents; Bacteremia; Carbapenems; Drug Therapy, Combination; Humans; Korea; Linezolid; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Salvage Therapy; Staphylococcal Infections; Treatment Outcome; Vancomycin; Young Adult | 2009 |
Hematologic safety profile of linezolid in the early periengraftment period after allogeneic stem cell transplantation.
Topics: Acetamides; Adult; Anti-Infective Agents; Drug-Related Side Effects and Adverse Reactions; Enterococcus; Female; Graft Survival; Gram-Positive Bacterial Infections; Hematopoietic Stem Cell Transplantation; Humans; Linezolid; Male; Middle Aged; Models, Biological; Oxazolidinones; Retrospective Studies; Time Factors; Transplantation, Homologous; Vancomycin Resistance | 2009 |
[Pharmacokinetic evaluation of linezolid in patients with major thermal injuries].
Topics: Acetamides; Adolescent; Adult; Anti-Infective Agents; Area Under Curve; Burns; Chromatography, High Pressure Liquid; Female; Humans; Infusions, Intravenous; Linezolid; Male; Metabolic Clearance Rate; Middle Aged; Oxazolidinones; Young Adult | 2010 |
Characterization of baseline methicillin-resistant Staphylococcus aureus isolates recovered from phase IV clinical trial for linezolid.
Topics: Acetamides; Americas; Anti-Bacterial Agents; Bacterial Typing Techniques; Cluster Analysis; DNA Fingerprinting; Drug Resistance, Bacterial; Europe; Genotype; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Epidemiology; Oxazolidinones; Soft Tissue Infections; South Africa; Staphylococcal Skin Infections; Vancomycin | 2010 |
Pharmacokinetics of linezolid in septic patients with and without extended dialysis.
Topics: Acetamides; Acute Kidney Injury; Aged; Anti-Infective Agents; Critical Care; Drug Monitoring; Female; Hepatectomy; Humans; Infusions, Intravenous; Linezolid; Liver Transplantation; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Oxazolidinones; Renal Dialysis; Sepsis; Treatment Outcome | 2010 |
Limited sampling strategies for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis.
Topics: Acetamides; Adult; Anti-Infective Agents; Area Under Curve; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Linezolid; Oxazolidinones; Prospective Studies; Tandem Mass Spectrometry; Tuberculosis, Multidrug-Resistant; Young Adult | 2010 |
Efficacy and safety of linezolid versus vancomycin for the treatment of complicated skin and soft-tissue infections proven to be caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Chi-Square Distribution; Female; Humans; Length of Stay; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Prospective Studies; Soft Tissue Infections; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2010 |
Linezolid more efficacious than vancomycin to eradicate infecting organism in critically ill patients with Gram-positive infections.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Critical Care; Critical Illness; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Length of Stay; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Prospective Studies; Treatment Outcome; Vancomycin | 2010 |
Assessment of linezolid efficacy and safety in MDR- and XDR-TB: an Indian perspective.
Topics: Acetamides; Anti-Infective Agents; Antitubercular Agents; Drug Resistance, Bacterial; Drug Resistance, Multiple; Female; Humans; India; Linezolid; Male; Oxazolidinones; Tuberculosis, Pulmonary | 2010 |
Unexpected effect of rifampin on the pharmacokinetics of linezolid: in silico and in vitro approaches to explain its mechanism.
Topics: Acetamides; Adult; Anti-Infective Agents; Antibiotics, Antitubercular; Area Under Curve; Cells, Cultured; Computer Simulation; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Half-Life; Hepatocytes; Humans; Ketoconazole; Linezolid; Male; Oxazolidinones; Rifampin; Testosterone; Tissue Distribution; Young Adult | 2011 |
Clinical outcomes by methicillin-resistant Staphylococcus aureus staphylococcal cassette chromosome mec type: isolates recovered from a phase IV clinical trial of linezolid and vancomycin for complicated skin and skin structure infections.
Topics: Acetamides; Anti-Bacterial Agents; Chromosomes, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Skin Diseases; Staphylococcal Infections; Vancomycin | 2010 |
Comparison of the pharmacokinetics of two dosage regimens of linezolid in multidrug-resistant and extensively drug-resistant tuberculosis patients.
Topics: Acetamides; Adult; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Female; Humans; Linezolid; Male; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2010 |
Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers.
Topics: Acetamides; Antitubercular Agents; Dose-Response Relationship, Drug; Humans; Linezolid; Mycobacterium tuberculosis; Oxazolidinones; Serum Bactericidal Test; Treatment Outcome | 2010 |
Aqueous and vitreous penetration of linezolid and levofloxacin after oral administration.
Topics: Acetamides; Administration, Oral; Adult; Aged; Anti-Bacterial Agents; Aqueous Humor; Drug Therapy, Combination; Endophthalmitis; Female; Humans; Levofloxacin; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Ofloxacin; Oxazolidinones; Time Factors; Tissue Distribution; Vitrectomy; Vitreous Body | 2010 |
Biomarker-assisted dose selection for safety and efficacy in early development of PNU-100480 for tuberculosis.
Topics: Acetamides; Adolescent; Adult; Animals; Antitubercular Agents; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Linezolid; Microbial Sensitivity Tests; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Pyrazinamide; Rats; Serum Bactericidal Test; Treatment Outcome; Tuberculosis; Young Adult | 2011 |
The impact of linezolid and vancomycin treatment on local signs and symptoms of inflammation among pediatric patients with complicated skin and skin structure infections.
Topics: Acetamides; Anti-Bacterial Agents; Child; Child, Preschool; Drug Therapy, Combination; Female; Gram-Positive Bacterial Infections; Hospitalization; Humans; Infant; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pediatrics; Skin Diseases, Bacterial; Treatment Outcome; Vancomycin | 2011 |
Efficacy and safety of linezolid in liver transplant patients.
Topics: Acetamides; Adult; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Incidence; Linezolid; Liver Transplantation; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Thrombocytopenia; Treatment Outcome; Vancomycin Resistance | 2011 |
Population pharmacokinetic and pharmacodynamic analysis of linezolid and a hematologic side effect, thrombocytopenia, in Japanese patients.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Asian People; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Thrombocytopenia | 2011 |
Pharmacokinetics of intravenous and oral linezolid in adults with cystic fibrosis.
Topics: Acetamides; Administration, Oral; Adult; Anti-Infective Agents; Cystic Fibrosis; Female; Humans; Injections, Intravenous; Linezolid; Male; Models, Biological; Monte Carlo Method; Oxazolidinones; Young Adult | 2011 |
A randomized, double-blind phase 2 study comparing the efficacy and safety of an oral fusidic acid loading-dose regimen to oral linezolid for the treatment of acute bacterial skin and skin structure infections.
Topics: Acetamides; Acute Disease; Administration, Oral; Adult; Anti-Bacterial Agents; Cellulitis; Double-Blind Method; Drug Administration Schedule; Female; Fusidic Acid; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Skin Diseases, Bacterial; Treatment Outcome; Young Adult | 2011 |
Determination of tissue penetration and pharmacokinetics of linezolid in patients with diabetic foot infections using in vivo microdialysis.
Topics: Acetamides; Aged; Diabetic Foot; Humans; L-Lactate Dehydrogenase; Linezolid; Male; Microdialysis; Middle Aged; Oxazolidinones; Thigh; Wound Infection | 2011 |
Lack of an effect of standard and supratherapeutic doses of linezolid on QTc interval prolongation.
Topics: Acetamides; Adult; Anti-Infective Agents; Arrhythmias, Cardiac; Aza Compounds; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Fluoroquinolones; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Moxifloxacin; Oxazolidinones; Quinolines; Young Adult | 2011 |
Randomized, double-blind, phase II, multicenter study evaluating the safety/tolerability and efficacy of JNJ-Q2, a novel fluoroquinolone, compared with linezolid for treatment of acute bacterial skin and skin structure infection.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Double-Blind Method; Female; Fluoroquinolones; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Skin Diseases, Bacterial; Soft Tissue Infections; Staphylococcus aureus; Treatment Outcome; United States; Young Adult | 2011 |
Linezolid: an effective, safe and cheap drug for patients failing multidrug-resistant tuberculosis treatment in India.
Topics: Acetamides; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antitubercular Agents; Drug Costs; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Female; Fluoroquinolones; Humans; India; Linezolid; Male; Middle Aged; Oxazolidinones; Prospective Studies; Treatment Outcome; Young Adult | 2012 |
Linezolid versus vancomycin antibiotic lock solution for the prevention of nontunneled catheter-related blood stream infections in hemodialysis patients: a prospective randomized study.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Bacteremia; Catheter-Related Infections; Catheters, Indwelling; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Linezolid; Male; Middle Aged; Oxazolidinones; Prospective Studies; Renal Dialysis; RNA, Ribosomal, 23S; Treatment Outcome; Vancomycin | 2012 |
A randomised, double-blind trial comparing ceftobiprole medocaril with ceftriaxone with or without linezolid for the treatment of patients with community-acquired pneumonia requiring hospitalisation.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Ceftriaxone; Cephalosporins; Community-Acquired Infections; Disease Eradication; Double-Blind Method; Drug Therapy, Combination; Female; Hospitalization; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pneumonia, Bacterial; Treatment Outcome; Young Adult | 2012 |
Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Cross Infection; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Treatment Outcome | 2012 |
Immediate hematological toxicity of linezolid in healthy volunteers with different body weight: a phase I clinical trial.
Topics: Acetamides; Adolescent; Adult; Anti-Infective Agents; Body Weight; Erythrocyte Count; Hemoglobins; Humans; Leukocyte Count; Linezolid; Male; Oxazolidinones; Platelet Count; Young Adult | 2012 |
Alveolar diffusion and pharmacokinetics of linezolid administered in continuous infusion to critically ill patients with ventilator-associated pneumonia.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Critical Illness; Female; Humans; Infusions, Intravenous; Linezolid; Male; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Pneumonia, Ventilator-Associated; Prospective Studies; Pulmonary Alveoli; Serum; Staphylococcus aureus | 2012 |
Rhabdomyolysis in a patient treated with linezolid for extensively drug-resistant tuberculosis.
Topics: Acetamides; Adult; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Male; Oxazolidinones; Rhabdomyolysis | 2012 |
In vitro activity and microbiological efficacy of tedizolid (TR-700) against Gram-positive clinical isolates from a phase 2 study of oral tedizolid phosphate (TR-701) in patients with complicated skin and skin structure infections.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Culture Media; Double-Blind Method; Drug Administration Schedule; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Organophosphates; Oxazoles; Oxazolidinones; Skin; Staphylococcal Skin Infections; Staphylococcus; Tetrazoles | 2012 |
Efficacy of linezolid-based salvage therapy compared with glycopeptide-based therapy in patients with persistent methicillin-resistant Staphylococcus aureus bacteremia.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacteremia; Female; Glycopeptides; Humans; Linezolid; Logistic Models; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Odds Ratio; Oxazolidinones; Risk Factors; Salvage Therapy; Staphylococcal Infections; Treatment Outcome | 2012 |
A randomized, evaluator-blind, phase 2 study comparing the safety and efficacy of omadacycline to those of linezolid for treatment of complicated skin and skin structure infections.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Aztreonam; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Minocycline; Oxazolidinones; Placebos; Skin; Skin Diseases, Bacterial; Staphylococcal Infections; Treatment Outcome | 2012 |
Characterization of methicillin-resistant Staphylococcus aureus strains recovered from a phase IV clinical trial for linezolid versus vancomycin for treatment of nosocomial pneumonia.
Topics: Acetamides; Anti-Bacterial Agents; Cluster Analysis; Cross Infection; DNA, Bacterial; Double-Blind Method; Electrophoresis, Gel, Pulsed-Field; Genotype; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Epidemiology; Multilocus Sequence Typing; Oxazolidinones; Pneumonia, Staphylococcal; Prospective Studies; Staphylococcal Protein A; United States; Vancomycin | 2012 |
Linezolid for treatment of chronic extensively drug-resistant tuberculosis.
Topics: Acetamides; Adult; Antitubercular Agents; Drug Resistance, Bacterial; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Female; Humans; Kaplan-Meier Estimate; Linezolid; Male; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Sputum; Young Adult | 2012 |
Lessons from a randomised clinical trial for multidrug-resistant tuberculosis.
Topics: Acetamides; Antitubercular Agents; Directly Observed Therapy; Double-Blind Method; Drug Monitoring; Female; Humans; Linezolid; Male; Mycobacterium tuberculosis; Oxazolidinones; Patient Dropouts; Pilot Projects; Research Design; South Africa; Sputum; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2012 |
Weight-adjusted versus fixed dose of linezolid for Chinese healthy volunteers of higher and lower body weight: a Phase I pharmacokinetic and pharmacodynamic study.
Topics: Acetamides; Administration, Intravenous; Adult; Anti-Infective Agents; Asian People; Body Weight; Dose-Response Relationship, Drug; Humans; Linezolid; Male; Monte Carlo Method; Oxazolidinones | 2013 |
Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients.
Topics: Acetamides; Adult; Aged; Antitubercular Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clarithromycin; Drug Interactions; Drug Monitoring; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Prospective Studies; Tuberculosis, Multidrug-Resistant; Young Adult | 2013 |
Linezolid in late-chronic prosthetic joint infection caused by gram-positive bacteria.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthritis; Female; Gram-Positive Bacteria; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Prospective Studies; Prosthesis-Related Infections; Treatment Outcome | 2013 |
In vitro, in vivo, and clinical studies of tedizolid to assess the potential for peripheral or central monoamine oxidase interactions.
Topics: Acetamides; Adolescent; Adult; Aged; Animals; Anti-Bacterial Agents; Blood Pressure; Female; Humans; Linezolid; Male; Mice; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organophosphates; Oxazoles; Oxazolidinones; Pseudoephedrine; Serotonin; Serotonin Agents; Tetrazoles; Tyramine; Young Adult | 2013 |
Clinical validation of the analysis of linezolid and clarithromycin in oral fluid of patients with multidrug-resistant tuberculosis.
Topics: Acetamides; Adult; Antitubercular Agents; Area Under Curve; Clarithromycin; Confidence Intervals; Drug Monitoring; Female; Humans; Linezolid; Male; Metabolic Clearance Rate; Oxazolidinones; Prospective Studies; Saliva; Tuberculosis, Multidrug-Resistant; Young Adult | 2013 |
Pharmacokinetics and relative bioavailability evaluation of linezolid suspension and tablet formulations.
Topics: Acetamides; Adult; Anti-Infective Agents; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Drug Stability; Humans; Linezolid; Male; Oxazolidinones; Suspensions; Tablets | 2013 |
Pre-emptive broad-spectrum treatment for ventilator-associated pneumonia in high-risk patients.
Topics: Acetamides; Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Cardiac Surgical Procedures; Female; Humans; Intensive Care Units; Linezolid; Male; Meropenem; Oxazolidinones; Pneumonia, Ventilator-Associated; Prospective Studies; Risk Factors; Thienamycins | 2013 |
The impact of linezolid versus vancomycin on surgical interventions for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Chi-Square Distribution; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Multivariate Analysis; Oxazolidinones; Prospective Studies; Staphylococcal Skin Infections; Vancomycin | 2013 |
Impact of weight on treatment efficacy and safety in complicated skin and skin structure infections and nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Body Weight; Cross Infection; Dose-Response Relationship, Drug; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Staphylococcal Skin Infections; Treatment Outcome; Vancomycin | 2013 |
The ZEPHyR study: a randomized comparison of linezolid and vancomycin for MRSA pneumonia.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Cross Infection; Double-Blind Method; Humans; Kidney Diseases; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Prospective Studies; Survival Analysis; Treatment Outcome; Vancomycin | 2013 |
A comparison of microbiology and demographics among patients with healthcare-associated, hospital-acquired, and ventilator-associated pneumonia: a retrospective analysis of 1184 patients from a large, international study.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteria; Cross Infection; Demography; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pneumonia, Ventilator-Associated; Retrospective Studies; Risk Factors; Vancomycin | 2013 |
Impact of patient characteristics and infection type on clinical outcomes of patients who received linezolid or vancomycin for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: a pooled data analysis.
Topics: Acetamides; Aged; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Prospective Studies; Skin; Staphylococcal Skin Infections; Treatment Outcome; Vancomycin | 2014 |
Comparison of digital planimetry and ruler technique to measure ABSSSI lesion sizes in the ESTABLISH-1 study.
Topics: Acetamides; Anti-Bacterial Agents; Erythema; Humans; Image Interpretation, Computer-Assisted; Linezolid; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; United States | 2014 |
The emergence of linezolid resistance among Enterococci in intestinal microbiota of treated patients is unrelated to individual pharmacokinetic characteristics.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Intestines; Linezolid; Male; Middle Aged; Oxazolidinones; Staphylococcus; Streptococcus | 2014 |
Target site pharmacokinetics of linezolid after single and multiple doses in diabetic patients with soft tissue infection.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Diabetes Mellitus, Type 2; Female; Foot Diseases; Humans; Linezolid; Male; Microdialysis; Middle Aged; Oxazolidinones; Soft Tissue Infections | 2014 |
A phase 3 randomized double-blind comparison of ceftobiprole medocaril versus ceftazidime plus linezolid for the treatment of hospital-acquired pneumonia.
Topics: Acetamides; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Ceftazidime; Cephalosporins; Cross Infection; Double-Blind Method; Drug Therapy; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pneumonia, Bacterial; Treatment Outcome; Young Adult | 2014 |
Once-weekly dalbavancin versus daily conventional therapy for skin infection.
Topics: Acetamides; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Double-Blind Method; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Linezolid; Male; Middle Aged; Oxazolidinones; Skin Diseases, Bacterial; Teicoplanin; Vancomycin; Young Adult | 2014 |
Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial.
Topics: Acetamides; Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Double-Blind Method; Female; Humans; Linezolid; Male; Middle Aged; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; Treatment Outcome; Young Adult | 2014 |
Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Critical Illness; Dose-Response Relationship, Drug; Female; Humans; Intensive Care Units; Linezolid; Male; Middle Aged; Oxazolidinones; Prospective Studies | 2014 |
Single-dose linezolid pharmacokinetics in critically ill patients with impaired renal function especially chronic hemodialysis patients.
Topics: Acetamides; Adult; Critical Illness; Female; Humans; Kidney Failure, Chronic; Linezolid; Male; Middle Aged; Oxazolidinones; Renal Dialysis; Young Adult | 2014 |
Modeling the economic impact of linezolid versus vancomycin in confirmed nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cost-Benefit Analysis; Cross Infection; Double-Blind Method; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Models, Economic; Oxazolidinones; Pneumonia, Staphylococcal; Prospective Studies; Vancomycin | 2014 |
Safety, tolerability, and efficacy of GSK1322322 in the treatment of acute bacterial skin and skin structure infections.
Topics: Acetamides; Adult; Amidohydrolases; Anti-Bacterial Agents; beta-Lactamases; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Resistance, Multiple, Bacterial; Female; Humans; Hydroxamic Acids; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Skin Infections; Treatment Outcome | 2014 |
Randomized non-inferiority trial to compare trimethoprim/sulfamethoxazole plus rifampicin versus linezolid for the treatment of MRSA infection.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Rifampin; Staphylococcal Infections; Survival Analysis; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination; Young Adult | 2015 |
Platelet profile in patients with acute bacterial skin and skin structure infections receiving tedizolid or linezolid: findings from the Phase 3 ESTABLISH clinical trials.
Topics: Acetamides; Anti-Bacterial Agents; Blood Platelets; Double-Blind Method; Drug Administration Schedule; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Platelet Count; Staphylococcal Skin Infections; Tetrazoles | 2014 |
Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Critical Illness; Drug Monitoring; Female; Humans; Infusions, Intravenous; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Obesity; Organ Dysfunction Scores; Oxazolidinones; Pneumonia, Ventilator-Associated; Prospective Studies; Risk Assessment; Rome | 2015 |
Analysis of the phase 3 ESTABLISH trials of tedizolid versus linezolid in acute bacterial skin and skin structure infections.
Topics: Acetamides; Anti-Bacterial Agents; Double-Blind Method; Female; Humans; Linezolid; Male; Oxazolidinones; Skin Diseases, Bacterial; Skin Diseases, Infectious; Staphylococcal Skin Infections; Tetrazoles | 2015 |
Pharmacokinetic/pharmacodynamic research on three different infusion time regimens of linezolid in healthy Chinese volunteers.
Topics: Acetamides; Adult; Anti-Infective Agents; Area Under Curve; Female; Humans; Infusions, Intravenous; Linezolid; Male; Microbial Sensitivity Tests; Monte Carlo Method; Oxazolidinones; Volunteers | 2015 |
Single- and Multiple-Dose Study To Determine the Safety, Tolerability, Pharmacokinetics, and Food Effect of Oral MRX-I versus Linezolid in Healthy Adult Subjects.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Area Under Curve; Biological Availability; Body Mass Index; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Drug Dosage Calculations; Fasting; Female; Food-Drug Interactions; Gram-Positive Bacterial Infections; Healthy Volunteers; Humans; Linezolid; Male; Models, Statistical; Oxazolidinones; Patient Safety; Pyridones | 2017 |
A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections.
Topics: Adult; Anti-Bacterial Agents; Double-Blind Method; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pyridones; Soft Tissue Infections; Treatment Outcome | 2022 |
Efficacy and safety of tedizolid for the treatment of ventilated gram-positive hospital-acquired or ventilator-associated bacterial pneumonia in Japanese patients: Results from a subgroup analysis of a phase 3, randomized, double-blind study comparing ted
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bacteria; Double-Blind Method; Hospitals; Humans; Japan; Linezolid; Organophosphates; Oxazolidinones; Pneumonia, Bacterial; Pneumonia, Ventilator-Associated; Skin Diseases, Bacterial; Tetrazoles; Ventilators, Mechanical | 2022 |
A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections-authors' response.
Topics: Adult; Anti-Bacterial Agents; Double-Blind Method; Humans; Linezolid; Oxazolidinones; Pyridones; Skin Diseases, Bacterial; Soft Tissue Infections; Treatment Outcome | 2022 |
A phase IIb, open-label, randomized controlled dose ranging multi-centre trial to evaluate the safety, tolerability, pharmacokinetics and exposure-response relationship of different doses of delpazolid in combination with bedaquiline delamanid moxifloxaci
Topics: Adult; Antitubercular Agents; Drug Therapy, Combination; Humans; Linezolid; Moxifloxacin; Oxazolidinones; Treatment Outcome; Tuberculosis, Pulmonary | 2023 |
1709 other study(ies) available for oxazolidin-2-one and linezolid
| Article | Year |
|---|---|
Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections.
Topics: Acetamides; Animals; Anti-Infective Agents; Dogs; Drug Resistance, Microbial; Drug Resistance, Multiple; Female; Linezolid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Rats | 1996 |
In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Bacterial Infections; Drug Therapy, Combination; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Injections, Intravenous; Injections, Subcutaneous; Linezolid; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcus aureus; Vancomycin | 1996 |
In vitro activities in new oxazolidinone antimicrobial agents against enterococci.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 1996 |
Activities of RPR 106972 (a new oral streptogramin), cefditoren (a new oral cephalosporin), two new oxazolidinones (U-100592 and U-100766), and other oral and parenteral agents against 203 penicillin-susceptible and -resistant pneumococci.
Topics: Acetamides; Amino Acid Sequence; Anti-Bacterial Agents; Cephalosporins; Linezolid; Microbial Sensitivity Tests; Molecular Sequence Data; Oxazoles; Oxazolidinones; Penicillin Resistance; Streptococcus pneumoniae; Virginiamycin | 1996 |
In vitro activities of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains of Streptococcus pneumoniae.
Topics: Acetamides; Anti-Bacterial Agents; beta-Lactam Resistance; Ceftriaxone; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Penicillins; Streptococcus pneumoniae | 1996 |
In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Drug Resistance, Microbial; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Vancomycin | 1996 |
In vitro antimicrobial activities and spectra of U-100592 and U-100766, two novel fluorinated oxazolidinones.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Bacteria, Anaerobic; Diffusion; Gram-Negative Bacteria; Gram-Positive Cocci; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 1996 |
In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Nafcillin; Oxazoles; Oxazolidinones; Penicillins; Staphylococcus aureus; Staphylococcus epidermidis; Time Factors; Vancomycin | 1996 |
In vitro activities of two novel oxazolidinones (U100592 and U100766), a new fluoroquinolone (trovafloxacin), and dalfopristin-quinupristin against Staphylococcus aureus and Staphylococcus epidermidis.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Drug Synergism; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Naphthyridines; Oxazoles; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Time Factors; Virginiamycin | 1996 |
In vitro activities of the oxazolidinone antibiotics U-100592 and U-100766 against Staphylococcus aureus and coagulase-negative Staphylococcus species.
Topics: Acetamides; Anti-Bacterial Agents; Coagulase; Colony Count, Microbial; Linezolid; Oxazoles; Oxazolidinones; Staphylococcus; Staphylococcus aureus | 1997 |
Quality control guidelines for amoxicillin, amoxicillin-clavulanate, azithromycin, piperacillin-tazobactam, roxithromycin, ticarcillin, ticarcillin-clavulanate, trovafloxacin (CP 99,219), U-100592, and U-100766 for various National Committee for Clinical
Topics: Acetamides; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Azithromycin; Clavulanic Acids; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Naphthyridines; Oxazoles; Oxazolidinones; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Quality Control; Roxithromycin; Ticarcillin | 1996 |
Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Proteins; Coliphages; Culture Media; Escherichia coli; Linezolid; Microbial Sensitivity Tests; N-Formylmethionine; Oxazoles; Oxazolidinones; Poly U; Polyribosomes; Protein Biosynthesis; Ribosomes; Transcription, Genetic | 1997 |
Disk diffusion test interpretive criteria and quality control recommendations for testing linezolid (U-100766) and eperezolid (U-100592) with commercially prepared reagents.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Drug Resistance, Multiple; Evaluation Studies as Topic; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Indicators and Reagents; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Quality Control | 1997 |
Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and Ente
Topics: Acetamides; Anti-Bacterial Agents; Coagulase; Enterococcus faecalis; Enterococcus faecium; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcus aureus; Vancomycin | 1998 |
Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring.
Topics: Acetamides; Anti-Bacterial Agents; Caco-2 Cells; Enterococcus faecalis; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Permeability; Piperazines; Pyridines; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Structure-Activity Relationship; Triazenes | 1998 |
The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Bacterial Proteins; Escherichia coli; Linezolid; Oxazoles; Oxazolidinones; Peptide Initiation Factors; Protein Synthesis Inhibitors; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer, Met; Staphylococcus aureus | 1998 |
The in-vitro activity of linezolid (U-100766) and tentative breakpoints.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacteroides fragilis; Bacteroides Infections; Colony Count, Microbial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Time Factors | 1998 |
A novel antimicrobial agent joins the battle against resistant bacteria.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Drug Resistance, Microbial; Humans; Linezolid; Oxazoles; Oxazolidinones | 1999 |
Successful treatment of persistent vancomycin-resistant Enterococcus faecium bacteremia with linezolid and gentamicin.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacteremia; Drug Resistance, Microbial; Drug Therapy, Combination; Enterococcus faecium; Female; Gentamicins; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Vancomycin | 1999 |
Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Antitubercular Agents; Female; Linezolid; Mice; Mycobacterium tuberculosis; Oxazoles; Oxazolidinones; Tuberculosis | 1999 |
Comparative in-vitro activities of moxifloxacin, trovafloxacin, quinupristin/dalfopristin and linezolid against staphylococci.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Fluoroquinolones; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Oxazoles; Oxazolidinones; Quinolines; Staphylococcal Infections; Staphylococcus; Virginiamycin | 1999 |
In vitro activity of linezolid against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Penicillin Resistance; Pneumococcal Infections; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Vancomycin | 1999 |
Susceptibility testing of linezolid by two standard methods.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus faecalis; Enterococcus faecium; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Sensitivity and Specificity; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes | 1999 |
In vitro activities of the oxazolidinone compounds linezolid (PNU-100766) and eperzolid (PNU-100592) against middle ear isolates of Streptococcus pneumoniae.
Topics: Acetamides; Acute Disease; Anti-Bacterial Agents; Child; Clindamycin; Drug Resistance, Microbial; Erythromycin; Humans; Linezolid; Microbial Sensitivity Tests; Otitis Media; Oxazoles; Oxazolidinones; Penicillins; Pneumococcal Infections; Streptococcus pneumoniae | 1999 |
In vitro activities of five new antimicrobial agents against Brucella melitensis.
Topics: Acetamides; Anti-Bacterial Agents; Brucella melitensis; Humans; Linezolid; Microbial Sensitivity Tests; Mupirocin; Oxazoles; Oxazolidinones; Rifabutin; Virginiamycin | 1999 |
In vitro activities of linezolid against important gram-positive bacterial pathogens including vancomycin-resistant enterococci.
Topics: Acetamides; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Enterococcus; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcus; Streptococcus; Teicoplanin; Vancomycin | 1999 |
In vitro susceptibilities of Bordetella pertussis and Bordetella parapertussis to the novel oxazolidinones eperezolid (PNU-100592) and linezolid (PNU-100766)
Topics: Acetamides; Anti-Bacterial Agents; Bordetella; Bordetella pertussis; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 1999 |
[A new antibacterial agent can stop resistance development. Expectations are connected to linezolid, an oxazolidinone with a new pharmacological action].
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Microbial; Humans; Linezolid; Oxazoles; Oxazolidinones | 1999 |
Methicillin-resistant Staphylococcus aureus infection in a renal allograft recipient treated successfully with a novel new antimicrobial agent (linezolid): new treatment options for infections due to resistant organisms.
Topics: Acetamides; Adult; Anti-Infective Agents; Drug Resistance, Microbial; Humans; Kidney Transplantation; Linezolid; Male; Methicillin Resistance; Oxazoles; Oxazolidinones; Staphylococcal Infections; Transplantation, Homologous | 1999 |
Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.
Topics: Acetamides; Binding Sites; Drug Resistance, Microbial; Halobacterium salinarum; Linezolid; Mutation; Nucleic Acid Conformation; Oxazoles; Oxazolidinones; Peptide Chain Initiation, Translational; Peptidyl Transferases; Protein Synthesis Inhibitors; Ribosomes; RNA, Ribosomal, 23S; RNA, Transfer, Met | 1999 |
Activities of the oxazolidinones linezolid and eperezolid in experimental intra-abdominal abscess due to Enterococcus faecalis or vancomycin-resistant Enterococcus faecium.
Topics: Abdominal Abscess; Acetamides; Animals; Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Linezolid; Male; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Rats; Rats, Sprague-Dawley; Treatment Outcome; Vancomycin | 1999 |
[Antibiosis. Therapeutic strategies in intensive care].
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Critical Care; Drug Therapy; Gram-Positive Bacterial Infections; Humans; Linezolid; Needs Assessment; Oxazoles; Oxazolidinones | 1999 |
Activity of linezolid against multi-resistant gram-positive bacteria from diverse hospitals in the United Kingdom.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Drug Resistance, Multiple; Enterococcus; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcus; Streptococcus; Streptococcus pneumoniae; United Kingdom | 2000 |
Successful treatment of vancomycin-resistant Enterococcus faecium bacteremia with linezolid after failure of treatment with synercid (quinupristin/dalfopristin).
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Bone Marrow Transplantation; Drug Administration Schedule; Drug Therapy, Combination; Enterococcus faecium; Follow-Up Studies; Gram-Positive Bacterial Infections; Humans; Leukemia, Myeloid, Acute; Linezolid; Male; Middle Aged; Oxazoles; Oxazolidinones; Postoperative Complications; Treatment Failure; Treatment Outcome; Vancomycin Resistance; Virginiamycin | 2000 |
Efficacy of linezolid in experimental otitis media.
Topics: Acetamides; Amoxicillin; Animals; Anti-Bacterial Agents; Chinchilla; Disease Models, Animal; Drug Resistance, Microbial; Drug Resistance, Multiple; Haemophilus Infections; Haemophilus influenzae; Humans; Linezolid; Otitis Media; Oxazoles; Oxazolidinones; Pneumococcal Infections; Streptococcus pneumoniae | 2000 |
Determination of linezolid in plasma by reversed-phase high-performance liquid chromatography.
Topics: Acetamides; Animals; Anti-Infective Agents; Calibration; Chromatography, High Pressure Liquid; Dogs; Indicators and Reagents; Linezolid; Mice; Oxazoles; Oxazolidinones; Quality Control; Rabbits; Rats; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1999 |
In vitro activities of daptomycin, vancomycin, linezolid, and quinupristin-dalfopristin against Staphylococci and Enterococci, including vancomycin- intermediate and -resistant strains.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Multiple; Enterococcus; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcus; Time Factors; Vancomycin; Virginiamycin | 2000 |
MICs of oxazolidinones for Rhodococcus equi strains isolated from humans and animals.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Horses; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Rhodococcus equi | 2000 |
Activity of linezolid against Gram-positive cocci possessing genes conferring resistance to protein synthesis inhibitors.
Topics: Acetamides; Drug Resistance, Microbial; Gram-Positive Cocci; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Protein Synthesis Inhibitors; Ribosomes | 2000 |
Comparative in vitro activities of linezolid, quinupristin-dalfopristin, moxifloxacin, and trovafloxacin against erythromycin-susceptible and -resistant streptococci.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Drug Resistance, Microbial; Drug Therapy, Combination; Erythromycin; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Oxazoles; Oxazolidinones; Quinolines; Streptococcus; Virginiamycin | 2000 |
In vitro activities of linezolid alone and in combination with amoxicillin, clarithromycin, and metronidazole against Helicobacter pylori.
Topics: Acetamides; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Synergism; Drug Therapy, Combination; Helicobacter pylori; Humans; Linezolid; Metronidazole; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Penicillins | 2000 |
Linezolid (Zyvox).
Topics: Acetamides; Administration, Oral; Anti-Infective Agents; Controlled Clinical Trials as Topic; Costs and Cost Analysis; Dose-Response Relationship, Drug; Drug Interactions; Humans; Infusions, Parenteral; Linezolid; Oxazoles; Oxazolidinones; Protein Synthesis Inhibitors | 2000 |
Linezolid approval brings new treatment option for resistant bacteria.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Infections; Drug Interactions; Drug Resistance, Microbial; Humans; Linezolid; Oxazoles; Oxazolidinones | 2000 |
Successful treatment of vertebral osteomyelitis with linezolid in a patient receiving hemodialysis and with persistent methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus bacteremias.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin Resistance; Osteomyelitis; Oxazolidinones; Renal Dialysis; Spinal Diseases; Spine; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2000 |
Oxidation of the novel oxazolidinone antibiotic linezolid in human liver microsomes.
Topics: Acetamides; Animals; Anti-Infective Agents; Carbon Radioisotopes; Cell Line; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Humans; Linezolid; Mass Spectrometry; Microsomes; Microsomes, Liver; Oxazoles; Oxazolidinones; Oxidation-Reduction | 2000 |
Linezolid, Alosetron, Levetiracetam.
Topics: Acetamides; Adult; Anti-Infective Agents; Anticonvulsants; Carbolines; Colonic Diseases, Functional; Contraindications; Drug Interactions; Female; Humans; Levetiracetam; Linezolid; Oxazolidinones; Piracetam; Serotonin Antagonists | 2000 |
Compatibility and stability of linezolid injection admixed with three quinolone antibiotics.
Topics: Acetamides; Anti-Infective Agents; Ciprofloxacin; Drug Stability; Levofloxacin; Linezolid; Ofloxacin; Oxazolidinones | 2000 |
Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.
Topics: Acetamides; Amino Acid Substitution; Anti-Bacterial Agents; Base Sequence; Binding Sites; Catalysis; Catalytic Domain; Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Genetic Engineering; Linezolid; Molecular Sequence Data; Molecular Structure; Mutagenesis; Nucleic Acid Conformation; Oxazolidinones; Peptidyl Transferases; Ribosomes; RNA, Bacterial; RNA, Ribosomal, 23S | 2000 |
Two new drugs join the war on superbugs.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Linezolid; Oxazolidinones; Pneumonia; Skin Diseases, Infectious; Vancomycin Resistance; Virginiamycin | 2000 |
Treatment of a vancomycin-resistant Enterococcus faecium ventricular drain infection with quinupristin/dalfopristin and review of the literature.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; Enterococcus faecium; Fatal Outcome; Female; Gram-Positive Bacterial Infections; Humans; Hydrocephalus; Injections, Intravenous; Injections, Intraventricular; Injections, Spinal; Linezolid; Middle Aged; Oxazoles; Oxazolidinones; Subarachnoid Hemorrhage; Tomography, X-Ray Computed; Vancomycin; Ventriculoperitoneal Shunt; Virginiamycin | 2000 |
Quinupristin-dalfopristin resistance among gram-positive bacteria in Taiwan.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Drug Resistance, Microbial; Drug Therapy, Combination; Fluoroquinolones; Gram-Positive Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Oxazolidinones; Quinolines; Taiwan; Virginiamycin | 2000 |
Linezolid therapy of Staphylococcus aureus experimental osteomyelitis.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Disease Models, Animal; Humans; Linezolid; Male; Osteomyelitis; Oxazolidinones; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus | 2000 |
Susceptibility of gram-positive cocci from 25 UK hospitals to antimicrobial agents including linezolid. The Linezolid Study Group.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Positive Cocci; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Penicillin Resistance | 2000 |
Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Linezolid; Meningitis, Pneumococcal; Oxazolidinones; Penicillin Resistance; Rabbits; Streptococcus pneumoniae | 2000 |
Linezolid: a new class of antibiotic.
Topics: Acetamides; Anti-Infective Agents; Drug Administration Schedule; Drug Costs; Drug Interactions; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Patient Selection; Practice Guidelines as Topic; Protein Synthesis Inhibitors | 2000 |
Clinical and microbiologic efficacy and safety profile of linezolid, a new oxazolidinone antibiotic.
Topics: Acetamides; Anti-Bacterial Agents; Clinical Trials as Topic; Community-Acquired Infections; Drug Resistance, Multiple; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Streptococcus; Treatment Outcome | 2000 |
In vitro activity of linezolid against multiply resistant Gram-positive clinical isolates.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple; Gram-Positive Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2001 |
In situ measurement of linezolid and vancomycin concentrations in intravascular catheter-associated biofilm.
Topics: Acetamides; Anti-Bacterial Agents; Biofilms; Catheterization; Gram-Positive Bacteria; Humans; Linezolid; Oxazolidinones; Staphylococcus aureus; Staphylococcus epidermidis; Vancomycin | 2001 |
Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Proteins; Carbon-Oxygen Ligases; Drug Resistance, Microbial; Endocarditis, Bacterial; Enterococcus faecium; Genotype; Linezolid; Male; Oxazolidinones; Rats; Rats, Wistar; Vancomycin Resistance | 2001 |
In vitro activity of linezolid against staphylococci.
Topics: Acetamides; Anti-Bacterial Agents; Coagulase; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Phenotype; Staphylococcus aureus | 2000 |
In vitro activity of linezolid (U-100766) against Haemophilus influenzae measured by three different susceptibility testing methods.
Topics: Acetamides; Anti-Bacterial Agents; beta-Lactamases; Haemophilus influenzae; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Sensitivity and Specificity | 2001 |
Activities of linezolid against rapidly growing mycobacteria.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium chelonae; Mycobacterium fortuitum; Oxazolidinones; Quality Control | 2001 |
Drug researchers take on 'superbugs'.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Drug Resistance, Microbial; Health Facility Administration; Infection Control; Linezolid; Mutation; Oxazolidinones; United States; United States Food and Drug Administration | 2000 |
The antibiotics crisis. We're in the midst of an escalating arms race with the microbe, and we may be losing.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Daptomycin; Drug Design; Drug Resistance, Microbial; Health Services Misuse; Humans; Linezolid; Oxazolidinones; Patient Compliance; Pharmacogenetics; United States | 2001 |
Efficacy of linezolid in a staphylococcal endocarditis rabbit model.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Endocarditis, Bacterial; Injections, Intravenous; Linezolid; Male; Oxazolidinones; Rabbits; Specific Pathogen-Free Organisms; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin | 2001 |
Linezolid and reversible myelosuppression.
Topics: Acetamides; Adult; Aged; Anemia; Anti-Infective Agents; Bone Marrow; Erythrocytes; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pancytopenia | 2001 |
[Multiresistant tuberculosis caused by Mycobacterium bovis and human immunodeficiency virus infection. Are there new therapeutic possibilities?].
Topics: Acetamides; Adult; AIDS-Related Opportunistic Infections; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antiretroviral Therapy, Highly Active; Antitubercular Agents; Clavulanic Acid; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; Humans; Isoniazid; Linezolid; Mycobacterium bovis; Oxazolidinones; Thioacetazone; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2001 |
In vitro activities of linezolid against multiple Nocardia species.
Topics: Acetamides; Anti-Bacterial Agents; Linezolid; Microbial Sensitivity Tests; Nocardia; Oxazolidinones; Species Specificity | 2001 |
Successful treatment of vancomycin-resistant Enterococcus endocarditis with oral linezolid.
Topics: Acetamides; Administration, Oral; Adult; Anti-Bacterial Agents; Endocarditis, Bacterial; Enterococcus faecium; Female; Follow-Up Studies; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Treatment Outcome; Vancomycin Resistance | 2001 |
Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Vancomycin | 2001 |
In vitro activity of linezolid and 11 other antimicrobials against 566 clinical isolates and comparison between NCCLS microdilution and Etest methods.
Topics: Acetamides; Anti-Bacterial Agents; Cell Culture Techniques; Enterococcus; Humans; Linezolid; Oxazolidinones; Staphylococcus; Streptococcus | 2001 |
Cardiovascular sympathomimetic amine interactions in rats treated with monoamine oxidase inhibitors and the novel oxazolidinone antibiotic linezolid.
Topics: Acetamides; Administration, Oral; Animals; Anti-Infective Agents; Blood Pressure; Dose-Response Relationship, Drug; Injections, Intravenous; Linezolid; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazolidinones; Rats; Rats, Sprague-Dawley; Sympathomimetics; Tyramine | 2001 |
Researchers describe latest strategies to combat antibiotic-resistant microbes.
Topics: Acetamides; Anti-Infective Agents; Cross Infection; Daptomycin; Drug Industry; Drug Resistance, Microbial; Drugs, Investigational; Europe; Humans; Linezolid; Oxazolidinones; Protein Synthesis Inhibitors | 2001 |
Pharmacokinetics and tissue penetration of linezolid following multiple oral doses.
Topics: Acetamides; Administration, Oral; Adult; Anti-Infective Agents; Area Under Curve; Half-Life; Humans; Linezolid; Male; Oxazolidinones; Tissue Distribution | 2001 |
Antibiotic available for compassionate use.
Topics: Acetamides; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Hotlines; Humans; Linezolid; Methicillin Resistance; Oxazoles; Oxazolidinones; Staphylococcal Infections | 1998 |
[In vitro activity of linezolid against clinical isolates of methicillin-resistant Staphylococcus aureus].
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcus aureus | 2001 |
Post-antibiotic growth suppression of linezolid against Gram-positive bacteria.
Topics: Acetamides; Anti-Bacterial Agents; Cell Division; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pneumoniae | 2001 |
A new and rapid method for monitoring the new oxazolidinone antibiotic linezolid in serum and urine by high performance liquid chromatography-integrated sample preparation.
Topics: Acetamides; Anti-Infective Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Linezolid; Molecular Structure; Oxazolidinones | 2001 |
Determination of linezolid in human plasma by LC-MS-MS.
Topics: Acetamides; Anti-Bacterial Agents; Chromatography, Liquid; Humans; Linezolid; Mass Spectrometry; Oxazolidinones | 2001 |
In vitro activities of linezolid, meropenem, and quinupristin-dalfopristin against group C and G streptococci, including vancomycin-tolerant isolates.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Meropenem; Microbial Sensitivity Tests; Oxazolidinones; Penicillin Resistance; Streptococcus; Thienamycins; Vancomycin Resistance; Virginiamycin | 2001 |
Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci.
Topics: Acetamides; Anti-Bacterial Agents; Base Sequence; Enterococcus; Linezolid; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Oxazolidinones; RNA, Bacterial; RNA, Ribosomal, 23S; Vancomycin Resistance | 2001 |
Linezolid breakpoints.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Drug Resistance, Microbial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2001 |
Systemic and intracerebral infections of mice with Listeria monocytogenes successfully treated with linezolid.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Brain Diseases; Disease Models, Animal; Female; Linezolid; Listeriosis; Mice; Microbial Sensitivity Tests; Oxazolidinones | 2001 |
Efficacy of linezolid in treatment of experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Aortic Valve; Colony Count, Microbial; Endocarditis, Bacterial; Heart Valve Diseases; Kidney; Linezolid; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2001 |
Susceptibility of a variety of clinical isolates to linezolid: a European inter-country comparison.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Positive Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2001 |
Successful treatment of vancomycin-resistant Enterococcus meningitis with linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Carcinoma, Renal Cell; Cerebellar Neoplasms; Cerebrospinal Fluid; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Kidney Neoplasms; Linezolid; Meningitis, Bacterial; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Treatment Outcome; Vancomycin Resistance; Ventriculostomy | 2001 |
Linezolid resistance in a clinical isolate of Staphylococcus aureus.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug Resistance, Microbial; Humans; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Peritonitis; Protein Synthesis Inhibitors; Staphylococcal Infections; Staphylococcus aureus | 2001 |
Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities
Topics: 4-Quinolones; Acetamides; Aminoglycosides; Anti-Bacterial Agents; Aza Compounds; Erythromycin; Fluoroquinolones; Gatifloxacin; Humans; Hydrogen-Ion Concentration; Ketolides; Linezolid; Macrolides; Microbial Sensitivity Tests; Minocycline; Moxifloxacin; Mycoplasma hominis; Mycoplasma pneumoniae; Oxazolidinones; Quinolines; Tetracyclines; Tigecycline; Ureaplasma urealyticum; Virginiamycin | 2001 |
Susceptibility testing with linezolid by different methods, in relation to published 'general breakpoints'.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Streptococcus pneumoniae | 2001 |
Successful treatment of disseminated Mycobacterium chelonae infection with linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Male; Middle Aged; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Oxazolidinones; Treatment Outcome | 2001 |
Ciprofloxacin- and methicillin-resistant staphylococcus aureus susceptible to moxifloxacin, levofloxacin, teicoplanin, vancomycin and linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Base Sequence; Ciprofloxacin; Drug Resistance, Multiple; Fluoroquinolones; Humans; Levofloxacin; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Sequence Data; Moxifloxacin; Ofloxacin; Oxazolidinones; Polymerase Chain Reaction; Quinolines; Sensitivity and Specificity; Staphylococcus aureus; Teicoplanin; Vancomycin | 2001 |
Linezolid for treatment of vancomycin-resistant enterococcal peritonitis.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Enterococcus faecalis; Female; Gram-Positive Bacterial Infections; Humans; Kidney Failure, Chronic; Linezolid; Oxazolidinones; Peritoneal Dialysis, Continuous Ambulatory; Peritonitis; Vancomycin Resistance | 2001 |
Activity of linezolid against levofloxacin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci in Hong Kong.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Gram-Positive Bacterial Infections; Hong Kong; Humans; Levofloxacin; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Ofloxacin; Oxazolidinones; Staphylococcus aureus; Streptococcus pneumoniae; Vancomycin Resistance | 2001 |
In vitro susceptibility of Coxiella burnetii to linezolid in comparison with its susceptibilities to quinolones, doxycycline, and clarithromycin.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Chlorocebus aethiops; Clarithromycin; Coxiella burnetii; Doxycycline; Fluoroquinolones; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Q Fever; Vero Cells | 2001 |
Determination of linezolid in human serum and urine by high-performance liquid chromatography.
Topics: Acetamides; Anti-Infective Agents; Chromatography, High Pressure Liquid; Humans; Linezolid; Molecular Structure; Oxazolidinones; Reproducibility of Results | 2001 |
In vitro activity of linezolid against Gram-positive uropathogens of hospitalized patients with complicated urinary tract infections.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus faecalis; Genotype; Germany; Gram-Positive Bacteria; Hospitalization; Humans; Linezolid; Methicillin; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Streptococcus; Urinary Tract Infections | 2001 |
In vitro activity of linezolid against clinical Gram-positive bacterial isolates from Taiwan: an area with a high prevalence of antibiotic resistance.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Taiwan | 2001 |
Linezolid treatment of prosthetic hip Infections due to methicillin-resistant Staphylococcus aureus (MRSA).
Topics: Acetamides; Aged; Anti-Bacterial Agents; Arthroplasty, Replacement, Hip; Female; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis | 2001 |
The DUEL study: a multi-center in vitro evaluation of linezolid compared with other antibiotics in the Netherlands.
Topics: Acetamides; Anti-Bacterial Agents; Glycopeptides; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Netherlands; Oxazolidinones | 2001 |
A simple, isocratic high-performance liquid chromatography assay for linezolid in human serum.
Topics: Acetamides; Anti-Infective Agents; Chromatography, High Pressure Liquid; Drug Stability; Humans; Linezolid; Oxazolidinones | 2001 |
Clinical experience with linezolid in the treatment of resistant gram-positive infections.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Prospective Studies | 2001 |
In vitro activity of PNU-100766 (linezolid), a new oxazolidinone antimicrobial, against Nocardia brasiliensis.
Topics: Acetamides; Amikacin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Dermatomycoses; Drug Therapy, Combination; Humans; Linezolid; Microbial Sensitivity Tests; Nocardia; Nocardia Infections; Oxazolidinones; Trimethoprim, Sulfamethoxazole Drug Combination | 2001 |
Antimicrobial activity of linezolid against Gram-positive cocci isolated in Brazil.
Topics: Acetamides; Anti-Bacterial Agents; Brazil; Cross Infection; Drug Resistance, Microbial; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin Resistance | 2001 |
Comparative activity of linezolid and other new agents against methicillin-resistant Staphylococcus aureus and teicoplanin-intermediate coagulase-negative staphylococci.
Topics: Acetamides; Anti-Bacterial Agents; Coagulase; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcus aureus; Teicoplanin | 2001 |
Linezolid levels in pancreatic secretions.
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Oxazolidinones; Pancreas; Pancreatitis, Acute Necrotizing | 2001 |
In vitro activity of linezolid against Gram-positive cocci isolated in Poland.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Oxazolidinones; Poland | 2001 |
In vitro antimicrobial activity of linezolid tested against vancomycin-resistant enterococci isolated in Brazilian hospitals.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Typing Techniques; Brazil; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecalis; Enterococcus faecium; Hospitals; Humans; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Protein Synthesis Inhibitors; Vancomycin Resistance | 2001 |
Linezolid-Induced anemia and thrombocytopenia.
Topics: Acetamides; Aged; Anemia; Anti-Infective Agents; Humans; Linezolid; Male; Osteomyelitis; Oxazolidinones; Staphylococcal Infections; Thrombocytopenia | 2002 |
Effect of linezolid in comparison with that of vancomycin on glycocalix production: in vitro study.
Topics: Acetamides; Anti-Bacterial Agents; Glycocalyx; Humans; Linezolid; Oxazolidinones; Protein Synthesis Inhibitors; Staphylococcus aureus; Vancomycin | 2002 |
Thrombocytopenia associated with linezolid therapy.
Topics: Acetamides; Anti-Infective Agents; Humans; Incidence; Linezolid; Oxazolidinones; Platelet Count; Thrombocytopenia | 2002 |
An investigation of the antimicrobial effects of linezolid on bacterial biofilms utilizing an in vitro pharmacokinetic model.
Topics: Acetamides; Anti-Bacterial Agents; Biofilms; Drug Evaluation, Preclinical; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus | 2002 |
Successful treatment of methicillin-resistant Staphylococcus aureus pulmonary infection with linezolid in a patient with cystic fibrosis.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Cystic Fibrosis; Female; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Sputum; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2002 |
Linezolid-resistant Enterococcus faecium isolated from a patient without prior exposure to an oxazolidinone: report from the SENTRY Antimicrobial Surveillance Program.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Population Surveillance | 2002 |
In vitro bactericidal activity of daptomycin against staphylococci.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Therapy, Combination; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus; Vancomycin; Virginiamycin | 2002 |
In vitro activity of linezolid against Gram-positive isolates causing infection in continuous ambulatory peritoneal dialysis patients.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Peritoneal Dialysis, Continuous Ambulatory | 2002 |
Nosocomial spread of linezolid-resistant, vancomycin-resistant Enterococcus faecium.
Topics: Acetamides; Anti-Bacterial Agents; Base Sequence; Cross Infection; Drug Resistance, Bacterial; Drug Resistance, Multiple; Enterococcus faecium; Gram-Positive Bacterial Infections; Hospital Design and Construction; Humans; Linezolid; Liver Transplantation; Molecular Sequence Data; Mutation; Oxazolidinones; Vancomycin Resistance | 2002 |
Oxazolidinone antibiotics target the P site on Escherichia coli ribosomes.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Translocation; Escherichia coli; Kinetics; Linezolid; Oxazoles; Oxazolidinones; Peptide Chain Initiation, Translational; Peptide Elongation Factor G; Peptide Elongation Factors; Peptidyl Transferases; Protein Biosynthesis; Ribosomes; RNA, Transfer, Met | 2002 |
Susceptibilities of Mycobacterium marinum to gatifloxacin, gemifloxacin, levofloxacin, linezolid, moxifloxacin, telithromycin, and quinupristin-dalfopristin (Synercid) compared to its susceptibilities to reference macrolides and quinolones.
Topics: Acetamides; Anti-Bacterial Agents; Fluoroquinolones; Humans; Ketolides; Linezolid; Macrolides; Microbial Sensitivity Tests; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Oxazolidinones; Virginiamycin | 2002 |
The use of linezolid in the treatment of vancomycin-resistant enterococcal septicaemia in two patients with burn injuries.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Burns; Drug Resistance, Microbial; Enterococcus; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Sepsis; Vancomycin | 2002 |
E test susceptibility testing of nosocomial Clostridium difficile isolates against metronidazole, vancomycin, fusidic acid and the novel agents moxifloxacin, gatifloxacin, and linezolid.
Topics: Acetamides; Anti-Infective Agents; Aza Compounds; Clostridioides difficile; Clostridium Infections; Cross Infection; Diarrhea; Fluoroquinolones; Fusidic Acid; Gatifloxacin; Humans; Linezolid; Metronidazole; Microbial Sensitivity Tests; Moxifloxacin; Oxazolidinones; Quinolines; Sensitivity and Specificity; Vancomycin | 2002 |
Economic evaluation of linezolid, flucloxacillin and vancomycin in the empirical treatment of cellulitis in UK hospitals: a decision analytical model.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Cellulitis; Cost-Benefit Analysis; Decision Support Techniques; Decision Trees; Drug Administration Schedule; Drug Resistance, Bacterial; Drug Utilization Review; Floxacillin; Gram-Positive Bacterial Infections; Hospital Costs; Hospitals, Public; Humans; Infection Control; Infusions, Intravenous; Linezolid; Oxazolidinones; Practice Patterns, Physicians'; United Kingdom; Vancomycin | 2001 |
Economic impact and formulary positioning of linezolid: a new anti-Gram-positive antimicrobial.
Topics: Acetamides; Anti-Bacterial Agents; Chemistry, Pharmaceutical; Cost-Benefit Analysis; Cross Infection; Drug Resistance, Bacterial; Formularies, Hospital as Topic; Gram-Positive Bacterial Infections; Humans; Infection Control; Linezolid; Methicillin Resistance; Oxazolidinones; Practice Guidelines as Topic; Staphylococcus aureus; United States | 2001 |
Linezolid is a specific inhibitor of 50S ribosomal subunit formation in Staphylococcus aureus cells.
Topics: Acetamides; Anti-Bacterial Agents; Inhibitory Concentration 50; Linezolid; Models, Chemical; Oxazolidinones; Protein Biosynthesis; Protein Subunits; Protein Synthesis Inhibitors; Ribosomal Proteins; Staphylococcus aureus | 2002 |
Synthesis and antibacterial activity of linezolid analogues.
Topics: Acetamides; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Streptococcus; Structure-Activity Relationship | 2002 |
Pharmacodynamic activity and efficacy of linezolid in a rat model of pneumococcal pneumonia.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Linezolid; Male; Oxazolidinones; Pneumonia, Pneumococcal; Rats; Rats, Sprague-Dawley; Streptococcus pneumoniae | 2002 |
Intrapulmonary pharmacokinetics of linezolid.
Topics: Acetamides; Administration, Oral; Adult; Anti-Infective Agents; Bronchoalveolar Lavage; Bronchoscopy; Epithelial Cells; Humans; Linezolid; Lung; Oxazolidinones; Prospective Studies; Pulmonary Alveoli | 2002 |
In vitro activity of linezolid against Clostridium difficile.
Topics: Acetamides; Anti-Bacterial Agents; Clostridioides difficile; Diarrhea; Drug Resistance, Bacterial; Enterocolitis, Pseudomembranous; Humans; Linezolid; Metronidazole; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin Resistance | 2002 |
Linezolid treatment for osteomyelitis due to vancomycin-resistant Enterococcus faecium.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Cross Infection; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Osteomyelitis; Oxazolidinones; Vancomycin Resistance | 2002 |
The responsibility of the pharmaceutical industry.
Topics: Acetamides; Anti-Bacterial Agents; Chemistry, Pharmaceutical; Drug Industry; Genome, Human; Humans; Linezolid; Oxazolidinones; Research | 2001 |
[Linezolid--a new antibiotic for treatment of methicillin resistant Staphylococcus aureus infections in trauma surgery? Report of 2 cases].
Topics: Acetamides; Adolescent; Aged; Anti-Infective Agents; Combined Modality Therapy; Female; Humans; Humeral Fractures; Linezolid; Methicillin Resistance; Multiple Trauma; Osteomyelitis; Oxazolidinones; Pneumonia, Staphylococcal; Postoperative Complications; Radiography; Reoperation; Staphylococcal Infections | 2002 |
In vitro activity of a new cephalosporin, RWJ-54428, against streptococci, enterococci and staphylococci, including glycopeptide-intermediate Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Enterococcus; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Staphylococcus aureus; Streptococcus; Virginiamycin | 2002 |
Determining Linezolid's baseline in vitro activity in Canada using gram-positive clinical isolates collected prior to its national release.
Topics: Acetamides; Anti-Bacterial Agents; Canada; Drug Approval; Drug Resistance; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2002 |
Serotonin syndrome and linezolid.
Topics: Acetamides; Anti-Infective Agents; Drug Interactions; Female; Humans; Linezolid; Middle Aged; Oxazolidinones; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome | 2002 |
Spectrum and potency evaluation of a new oxazolidinone, linezolid: report from the SENTRY Antimicrobial Surveillance Program, 1998-2000.
Topics: Acetamides; Americas; Anti-Bacterial Agents; Asia; Cell Division; Drug Resistance, Bacterial; Europe; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Substrate Specificity; Time Factors | 2002 |
A multicenter evaluation of linezolid antimicrobial activity in North America.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; North America; Oxazolidinones; Species Specificity; Substrate Specificity | 2002 |
Comparative activity of linezolid against staphylococci and enterococci isolated in Italy.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus faecalis; Enterococcus faecium; Humans; Italy; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus | 2002 |
Penetration of linezolid into bone, fat, muscle and haematoma of patients undergoing routine hip replacement.
Topics: Acetamides; Adipose Tissue; Anti-Infective Agents; Antibiotic Prophylaxis; Arthroplasty, Replacement, Hip; Bone and Bones; Cefamandole; Drug Therapy, Combination; Hematoma; Hip Joint; Humans; Linezolid; Muscles; Oxazolidinones; Tissue Distribution | 2002 |
In vitro activity of a novel oxazolidinone, AZD2563, against randomly selected and multiresistant Gram-positive cocci.
Topics: Acetamides; Anti-Bacterial Agents; Coagulase; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Streptococcus pneumoniae | 2002 |
Successful treatment of refractory disseminated Mycobacterium avium complex infection with the addition of linezolid and mefloquine.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Clarithromycin; Drug Therapy, Combination; Ethambutol; Fatal Outcome; Fluoroquinolones; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Linezolid; Male; Mefloquine; Middle Aged; Moxifloxacin; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Oxazolidinones; Quinolines | 2002 |
Letter in response to article in Journal of Infection: linezolid treatment of prosthetic hip infections due to methicillin resistant Staphylococcus aureus (M. Bassetti et al.) Journal of Infection 2001; 43: 148-157.
Topics: Acetamides; Anti-Bacterial Agents; Drug Therapy, Combination; Hip Prosthesis; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Prosthesis-Related Infections; Staphylococcus aureus | 2002 |
Linezolid-induced pancytopenia.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Humans; Linezolid; Male; Oxazolidinones; Pancytopenia | 2002 |
Thrombocytopenia secondary to linezolid administration: what is the risk?
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Oxazolidinones; Risk Factors; Thrombocytopenia | 2002 |
Linezolid-induced pure red blood cell aplasia.
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Red-Cell Aplasia, Pure | 2002 |
In vitro evaluation of AZD2563, a novel oxazolidinone, against 603 recent staphylococcal isolates.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2002 |
Hematologic effects of linezolid: summary of clinical experience.
Topics: Acetamides; Anemia; Anti-Infective Agents; Blood Cell Count; Clinical Trials as Topic; Hemoglobins; Humans; Linezolid; Neutropenia; Oxazolidinones; Retrospective Studies; Thrombocytopenia | 2002 |
The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Gram-Positive Bacteria; Linezolid; Molecular Structure; Oxazolidinones; Rats; Structure-Activity Relationship | 2002 |
In vitro activity of linezolid, synercid and telithromycin against genetically defined high level fluoroquinolone-resistant methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Drug Resistance, Multiple; In Vitro Techniques; Ketolides; Linezolid; Macrolides; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Vancomycin; Virginiamycin | 2002 |
Multicenter assessment of the linezolid spectrum and activity using the disk diffusion and Etest methods: report of the Zyvox(R) antimicrobial potency study in Latin America (LA-ZAPS).
Topics: Acetamides; Anti-Bacterial Agents; Diffusion; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Latin America; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Species Specificity; Vancomycin Resistance | 2002 |
In vitro activity of linezolid, quinupristin-dalfopristin, vancomycin, teicoplanin, moxifloxacin and mupirocin against methicillin-resistant Staphylococcus aureus: comparative evaluation by the E test and a broth microdilution method.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Moxifloxacin; Mupirocin; Oxazolidinones; Quinolines; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Vancomycin; Virginiamycin | 2002 |
Linezolid for the treatment of central nervous system infections in neurosurgical patients.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Central Nervous System Diseases; Fatal Outcome; Humans; Italy; Linezolid; Middle Aged; Oxazolidinones; Postoperative Complications | 2002 |
Comparative activities of the oxazolidinone AZD2563 and linezolid against selected recent North American isolates of Streptococcus pneumoniae.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Humans; Linezolid; Microbial Sensitivity Tests; North America; Oxazolidinones; Pneumococcal Infections; Streptococcus pneumoniae | 2002 |
Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Linezolid; Microbial Sensitivity Tests; Molecular Conformation; Molecular Mimicry; Oxazolidinones; Structure-Activity Relationship; Vancomycin Resistance | 2002 |
Time-dependent antibacterial effects of linezolid in experimental rabbit endocarditis.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Area Under Curve; Disease Models, Animal; Endocarditis, Bacterial; Half-Life; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Time Factors | 2002 |
The protein synthesis inhibitors, oxazolidinones and chloramphenicol, cause extensive translational inaccuracy in vivo.
Topics: Acetamides; Amino Acids; Aminoglycosides; Anti-Bacterial Agents; Chloramphenicol; Codon, Terminator; Drug Resistance, Bacterial; Escherichia coli; Frameshifting, Ribosomal; Genes, Reporter; Lac Operon; Linezolid; Mutation, Missense; Oxazolidinones; Protein Biosynthesis; Protein Synthesis Inhibitors | 2002 |
Treatment of Staphylococcus epidermidis ventriculo-peritoneal shunt infection with linezolid.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Device Removal; Female; Humans; Linezolid; Meningitis, Bacterial; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Ventriculoperitoneal Shunt | 2002 |
Linezolid-induced neuropathy.
Topics: Acetamides; Aged; Anti-Infective Agents; Humans; Linezolid; Male; Optic Nerve Diseases; Oxazolidinones; Peripheral Nervous System Diseases | 2002 |
Successful treatment of Enterococcus faecalis prosthetic valve endocarditis with linezolid.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Endocarditis, Bacterial; Enterococcus faecalis; Heart Valve Prosthesis; Humans; Linezolid; Male; Oxazolidinones; Treatment Outcome | 2002 |
Linezolid treatment of vancomycin-resistant Enterococcus faecium ventriculitis.
Topics: Acetamides; Anti-Bacterial Agents; Encephalitis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Hydrocephalus; Infant; Linezolid; Male; Oxazolidinones; Vancomycin Resistance; Ventriculoperitoneal Shunt | 2002 |
In vitro activity of the new oxazolidinone AZD2563 against Enterococci.
Topics: Acetamides; Drug Resistance, Bacterial; Enterococcus; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2002 |
Efficacy of linezolid against methicillin-resistant or vancomycin-insensitive Staphylococcus aureus in a model of hematogenous pulmonary infection.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Linezolid; Male; Methicillin Resistance; Mice; Oxazolidinones; Respiratory Tract Infections; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Vancomycin | 2002 |
Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis.
Topics: Acetamides; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gene Dosage; Genes, rRNA; Humans; Linezolid; Mutation; Oxazolidinones; Polymerase Chain Reaction; RNA, Ribosomal, 23S | 2002 |
[Enterococcus faecium cholangitis resistant to vancomycin and quinupristin-dalfopristin].
Topics: Acetamides; Aged; Anti-Bacterial Agents; Drug Resistance, Bacterial; Drug Therapy, Combination; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Spain; Treatment Failure; Vancomycin Resistance; Virginiamycin | 2002 |
[Linezolid in methicillin-resistant staphylococcus aureus infections].
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple; Humans; Linezolid; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2002 |
Endocarditis caused by methicillin-resistant Staphylococcus aureus: treatment failure with linezolid.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Endocarditis, Bacterial; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Treatment Failure | 2002 |
Isolation and characterization of process-related impurities in linezolid.
Topics: Acetamides; Chromatography, High Pressure Liquid; Drug Contamination; Linezolid; Oxazolidinones; Technology, Pharmaceutical | 2002 |
In vivo pharmacodynamics of a new oxazolidinone (linezolid).
Topics: Acetamides; Animals; Anti-Bacterial Agents; Area Under Curve; Drug Resistance, Bacterial; Female; Linezolid; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxazolidinones; Pneumococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Time Factors | 2002 |
Comparative in vitro activity of penicillin G, levofloxacin, moxifloxacin, telithromycin, pristinamycin, quinupristin-dalfopristin and linezolid against ofloxacin-intermediate and -resistant Streptococcus pneumoniae.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Drug Resistance, Bacterial; Fluoroquinolones; Ketolides; Lactams; Levofloxacin; Linezolid; Macrolides; Microbial Sensitivity Tests; Moxifloxacin; Ofloxacin; Oxazolidinones; Penicillin G; Pristinamycin; Quinolines; Streptococcus pneumoniae; Virginiamycin | 2002 |
A slow start to the new millennium. Zyvox, Concerta and Mifeprex headline the year.
Topics: Abortifacient Agents, Steroidal; Acetamides; Anti-Infective Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Drug Approval; Drug Interactions; Humans; Linezolid; Methylphenidate; Mifepristone; Oxazolidinones; Phytotherapy; United States; United States Food and Drug Administration | 2000 |
Virulence factor expression by Gram-positive cocci exposed to subinhibitory concentrations of linezolid.
Topics: Acetamides; Gram-Positive Cocci; Humans; Linezolid; Oxazolidinones; Phagocytes; Staphylococcus aureus; Streptococcus pyogenes; Virulence Factors | 2002 |
Linezolid-resistant enterococci: report of the first isolates in the United Kingdom.
Topics: Acetamides; Adult; Aged; Drug Resistance, Bacterial; Enterococcus; Female; Humans; Linezolid; Male; Oxazolidinones; United Kingdom | 2002 |
Linezolid penetration into osteo-articular tissues.
Topics: Acetamides; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Bone and Bones; Female; Humans; Linezolid; Male; Muscles; Osteoarthritis, Knee; Oxazolidinones; Synovial Fluid; Tissue Distribution | 2002 |
Method development for determining the antibacterial linezolid in human serum by micellar electrokinetic capillary chromatography.
Topics: Acetamides; Anti-Infective Agents; Chromatography, Micellar Electrokinetic Capillary; Humans; Linezolid; Oxazolidinones | 2002 |
Risk factors associated with the development of infection with linezolid- and vancomycin-resistant Enterococcus faecium.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Risk Factors; Vancomycin Resistance | 2002 |
Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Austria; Base Sequence; Cross Infection; DNA, Bacterial; Drug Resistance, Microbial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Sequence Data; Oxazolidinones; Polymerase Chain Reaction; Sensitivity and Specificity | 2002 |
Pharmacokinetics, toxicokinetics, distribution, metabolism and excretion of linezolid in mouse, rat and dog.
Topics: Acetamides; Animals; Anti-Infective Agents; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Linezolid; Male; Mass Spectrometry; Mice; Models, Chemical; Oxazolidinones; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Distribution | 2002 |
In vivo efficacy of continuous infusion versus intermittent dosing of linezolid compared to vancomycin in a methicillin-resistant Staphylococcus aureus rabbit endocarditis model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Area Under Curve; Dose-Response Relationship, Drug; Endocarditis, Bacterial; Female; Half-Life; Infusions, Intravenous; Linezolid; Methicillin Resistance; Oxazolidinones; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2002 |
Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells.
Topics: Acetamides; Dose-Response Relationship, Drug; Humans; Linezolid; Neutrophils; Oxazolidinones; Phagocytes; Staphylococcus epidermidis | 2002 |
Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype.
Topics: Acetamides; Anti-Bacterial Agents; DNA, Ribosomal; Drug Resistance, Bacterial; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcus aureus | 2002 |
Ribosomal and non-ribosomal resistance to oxazolidinones: species-specific idiosyncrasy of ribosomal alterations.
Topics: Acetamides; Anti-Bacterial Agents; Base Sequence; Drug Resistance, Bacterial; Drug Resistance, Microbial; Escherichia coli; Linezolid; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Mycobacterium smegmatis; Oxazolidinones; Ribosomes; RNA, Bacterial; RNA, Ribosomal, 23S; rRNA Operon; Species Specificity | 2002 |
In vitro activity of moxifloxacin, levofloxacin, gatifloxacin and linezolid against Mycobacterium tuberculosis.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Drug Resistance, Multiple, Bacterial; Female; Fluoroquinolones; Gatifloxacin; Humans; Levofloxacin; Linezolid; Male; Microbial Sensitivity Tests; Moxifloxacin; Mycobacterium tuberculosis; Ofloxacin; Oxazolidinones; Quinolines; Tuberculosis | 2002 |
In vitro activity of quinupristin/dalfopristin, linezolid, telithromycin and comparator antimicrobial agents against 13 species of coagulase-negative staphylococci.
Topics: Acetamides; Anti-Bacterial Agents; Coagulase; Drug Resistance, Multiple, Bacterial; Humans; Ketolides; Linezolid; Macrolides; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Virginiamycin | 2002 |
The in vitro and in vivo antibacterial characterization of vancomycin and linezolid against vancomycin-susceptible and -resistant enterococci.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Enterococcus faecalis; Humans; Linezolid; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin; Vancomycin Resistance | 2002 |
The efficacy and safety of linezolid as treatment for Staphylococcus aureus infections in compassionate use patients who are intolerant of, or who have failed to respond to, vancomycin.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Clinical Protocols; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Vancomycin Resistance | 2002 |
Sequential regimen for early post-surgical infective endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA), unresponsive to standard antibiotic therapy: a case report.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Cardiovascular Surgical Procedures; Drug Administration Schedule; Drug Therapy, Combination; Endocarditis, Bacterial; Female; Humans; Linezolid; Methicillin Resistance; Mitral Valve Insufficiency; Oxazolidinones; Staphylococcal Infections; Surgical Wound Infection; Virginiamycin | 2002 |
Synthesis and antibacterial activity of 5-substituted oxazolidinones.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Structure-Activity Relationship; Triazoles; Vancomycin | 2003 |
Linezolid to decrease length of stay in the hospital for patients with methicillin-resistant Staphylococcus aureus infection.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Injections, Intravenous; Length of Stay; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2003 |
Linezolid resistance in clinical isolates of Staphylococcus aureus.
Topics: Acetamides; Drug Resistance, Bacterial; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2003 |
Clinical failures of linezolid and implications for the clinical microbiology laboratory.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacteremia; Drug Resistance, Bacterial; Female; Humans; Klebsiella pneumoniae; Linezolid; Male; Middle Aged; Oxazolidinones; Staphylococcus aureus; Treatment Failure | 2002 |
In vitro activities of daptomycin, vancomycin, quinupristin- dalfopristin, linezolid, and five other antimicrobials against 307 gram-positive anaerobic and 31 Corynebacterium clinical isolates.
Topics: Acetamides; Anti-Bacterial Agents; Corynebacterium; Daptomycin; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin; Virginiamycin | 2003 |
Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
Topics: Acetamides; Anaerobic Threshold; Enterococcus faecium; Half-Life; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Vancomycin Resistance | 2003 |
In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first-line antituberculous drugs.
Topics: Acetamides; Antitubercular Agents; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2003 |
In vitro bactericidal activities of linezolid in combination with vancomycin, gentamicin, ciprofloxacin, fusidic acid, and rifampin against Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Ciprofloxacin; Drug Combinations; Fusidic Acid; Gentamicins; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Rifampin; Staphylococcus aureus; Vancomycin | 2003 |
Linezolid-induced lactic acidosis.
Topics: Acetamides; Acidosis, Lactic; Anti-Infective Agents; Female; Humans; Linezolid; Middle Aged; Nocardia Infections; Oxazolidinones | 2003 |
Multicentre assessment of linezolid antimicrobial activity and spectrum in Europe: report from the Zyvox antimicrobial potency study (ZAPS-Europe).
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Streptococcus; Vancomycin Resistance | 2002 |
Linezolid versus vancomycin for methicillin-resistant Staphylococcus aureus infections.
Topics: Acetamides; Anti-Bacterial Agents; Health Care Costs; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin | 2003 |
Summaries for patients. Linezolid.
Topics: Acetamides; Anti-Infective Agents; Biological Availability; Clinical Trials, Phase III as Topic; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Half-Life; Humans; Linezolid; Oxazolidinones | 2003 |
Species prevalence and antibacterial resistance of enterococci isolated in Kuwait hospitals.
Topics: Acetamides; Ampicillin Resistance; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Cross Infection; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Enterococcus; Enterococcus faecalis; Enterococcus faecium; Genotype; Gram-Positive Bacterial Infections; Hospitals; Humans; Kuwait; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Polymerase Chain Reaction; Prevalence; Vancomycin Resistance | 2003 |
Multicentre evaluation of the in vitro activity of linezolid in the Western Pacific.
Topics: Acetamides; Anti-Bacterial Agents; Asia, Eastern; Australia; Data Collection; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Streptococcus pneumoniae | 2003 |
Cost-minimization analysis and audit of antibiotic management of bone and joint infections with ambulatory teicoplanin, in-patient care or outpatient oral linezolid therapy.
Topics: Acetamides; Ambulatory Care; Anti-Bacterial Agents; Anti-Infective Agents; Bone Diseases, Infectious; Clinical Protocols; Cost Control; Costs and Cost Analysis; Humans; Joint Diseases; Linezolid; Oxazolidinones; Rifampin; Teicoplanin; United Kingdom | 2003 |
Persistent MRSA bacteremia in a patient with low linezolid levels.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2003 |
In vitro activity of linezolid against Clostridium difficile.
Topics: Acetamides; Clostridioides difficile; Drug Resistance, Multiple, Bacterial; Linezolid; Oxazolidinones | 2003 |
Activity of the oxazolidinones AZD2563 and linezolid against Corynebacterium jeikeium and other Corynebacterium spp.
Topics: Acetamides; Corynebacterium; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Oxazolidinones | 2003 |
Therapeutic efficacy of linezolid in extended clinical practice.
Topics: Acetamides; Anti-Infective Agents; Drug Labeling; Drug Storage; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Risk Assessment; Sensitivity and Specificity; Skin Diseases, Bacterial; Soft Tissue Infections; Temperature | 2003 |
Comparative activity of linezolid, quinupristin-dalfopristin and newer quinolones against Streptococcus pneumoniae.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Drug Therapy, Combination; Erythromycin; Humans; In Vitro Techniques; Linezolid; Oxazolidinones; Penicillin Resistance; Pneumococcal Infections; Streptococcus pneumoniae; Virginiamycin | 2003 |
Multi-system Infection with Nocardia farcinica-therapy with linezolid and minocycline.
Topics: Acetamides; Brain; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Magnetic Resonance Imaging; Male; Minocycline; Nocardia; Nocardia Infections; Oxazolidinones | 2003 |
Pharmacokinetics and efficacy of linezolid in a gerbil model of Streptococcus pneumoniae-induced acute otitis media.
Topics: Acetamides; Acute Disease; Administration, Oral; Animals; Anti-Bacterial Agents; Area Under Curve; Disease Models, Animal; Female; Gerbillinae; Linezolid; Microbial Sensitivity Tests; Otitis Media; Oxazolidinones; Penicillin Resistance; Pneumococcal Infections; Streptococcus pneumoniae | 2003 |
A high performance liquid chromatography (HPLC) assay for linezolid in continuous ambulatory peritoneal dialysis fluid (CAPDF).
Topics: Acetamides; Anti-Infective Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Linezolid; Oxazolidinones; Peritoneal Dialysis, Continuous Ambulatory; Reproducibility of Results | 2003 |
In vitro activity of linezolid alone and in combination with gentamicin, vancomycin or rifampicin against methicillin-resistant Staphylococcus aureus by time-kill curve methods.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular; Culture Media; Drug Combinations; Gentamicins; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Oxazolidinones; Rifampin; Staphylococcus aureus; Time Factors; Vancomycin | 2003 |
A severity score for complicated skin and soft tissue infections derived from phase III studies of linezolid.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Clinical Trials, Phase III as Topic; Cloxacillin; Female; Humans; Linezolid; Male; Middle Aged; Outcome Assessment, Health Care; Oxazolidinones; Penicillins; Prognosis; Risk; Severity of Illness Index; Skin Diseases, Bacterial; Soft Tissue Infections; Treatment Failure | 2003 |
Highly efficient CuI-catalyzed coupling of aryl bromides with oxazolidinones using Buchwald's protocol: a short route to linezolid and toloxatone.
Topics: Acetamides; Bromides; Catalysis; Copper; Iodides; Linezolid; Molecular Structure; Oxazolidinones; Spectroscopy, Fourier Transform Infrared | 2003 |
Mechanisms for linezolid-induced anemia and thrombocytopenia.
Topics: Acetamides; Aged; Anemia; Drug Hypersensitivity; Endocarditis, Bacterial; Female; Humans; Immunoglobulins, Intravenous; Linezolid; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Thrombocytopenia; Time Factors | 2003 |
Isolation of linezolid-resistant Enterococcus faecalis.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Prosthesis-Related Infections | 2003 |
Synergic activity of fluoroquinolones and linezolid against Mycobacterium tuberculosis.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis | 2003 |
First report of the activity of linezolid against Portuguese enterococci from human, animal and environmental sources.
Topics: Acetamides; Animals; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Enterococcus; Feces; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Portugal | 2003 |
Safety, efficacy and pharmacokinetics of linezolid for treatment of resistant Gram-positive infections in cancer patients with neutropenia.
Topics: Acetamides; Adult; Aged; Area Under Curve; Chi-Square Distribution; Drug Resistance, Bacterial; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Neoplasms; Neutropenia; Oxazolidinones; Prospective Studies; Statistics, Nonparametric | 2003 |
[Linezolid, a drug in a new class of antibiotics].
Topics: Acetamides; Anti-Infective Agents; Drug Interactions; Drug Resistance, Microbial; Humans; Linezolid; Oxazolidinones; Protein Synthesis Inhibitors | 2003 |
In vitro activity of linezolid against slowly growing nontuberculous Mycobacteria.
Topics: Acetamides; Anti-Bacterial Agents; Linezolid; Microbial Sensitivity Tests; Nontuberculous Mycobacteria; Oxazolidinones | 2003 |
Influences of linezolid, penicillin, and clindamycin, alone and in combination, on streptococcal pyrogenic exotoxin a release.
Topics: Acetamides; Bacterial Proteins; Clindamycin; Drug Therapy, Combination; Exotoxins; Humans; Linezolid; Membrane Proteins; Oxazolidinones; Penicillins; Streptococcal Infections; Streptococcus pyogenes | 2003 |
Serotonin syndrome after concomitant treatment with linezolid and citalopram.
Topics: Acetamides; Acidosis, Lactic; Citalopram; Drug Combinations; Humans; Linezolid; Oxazolidinones; Protein Synthesis Inhibitors; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Staphylococcus aureus; Thrombocytopenia | 2003 |
Introduction of erm(C) into a linezolid- and methicillin-resistant Staphylococcus aureus does not restore linezolid susceptibility.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Bacterial; Erythromycin; Linezolid; Methicillin Resistance; Methyltransferases; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus | 2003 |
Impact of methicillin-resistant Staphylococcus aureus infections on key health economic outcomes: does reducing the length of hospital stay matter?
Topics: Acetamides; Anti-Bacterial Agents; Cost of Illness; Health Care Costs; Hospital Costs; Humans; Length of Stay; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2003 |
Assessment of radioactive residues arising from radiolabel instability in a multiple dose tissue distribution study in rats.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Area Under Curve; Carbon Radioisotopes; Drug Stability; Half-Life; Linezolid; Male; Metabolic Clearance Rate; Oxazolidinones; Rats; Rats, Sprague-Dawley; Sodium Acetate; Time Factors; Tissue Distribution | 2003 |
Tooth discoloration after treatment with linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Cellulitis; Child; Female; HIV Infections; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Tooth Discoloration | 2003 |
Intrapulmonary penetration of linezolid.
Topics: Acetamides; Adult; Aged; Bronchoscopy; Female; Humans; Linezolid; Macrophages, Alveolar; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Respiratory Mucosa | 2003 |
[Contribution of linezolid to the treatment of nosocomial pneumonia].
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia; Staphylococcal Infections; Staphylococcus aureus | 2003 |
[Contribution of linezolid to the treatment of complicated infections of the skin and soft tissues].
Topics: Acetamides; Anti-Infective Agents; Controlled Clinical Trials as Topic; France; Humans; Linezolid; Oxacillin; Oxazolidinones; Penicillins; Skin Diseases, Bacterial; Soft Tissue Infections | 2003 |
Linezolid, a monoamine oxidase inhibiting antibiotic, and antidepressants.
Topics: Acetamides; Aged; Anti-Infective Agents; Comorbidity; Depressive Disorder; Drug Interactions; Humans; Linezolid; Male; Mianserin; Mirtazapine; Osteomyelitis; Oxazolidinones; Serotonin Syndrome | 2003 |
Worldwide assessment of linezolid's clinical safety and tolerability: comparator-controlled phase III studies.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Infective Agents; Clinical Trials, Phase III as Topic; Community-Acquired Infections; Cross Infection; Drug Interactions; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Multicenter Studies as Topic; Oxazolidinones; Protein Synthesis Inhibitors | 2003 |
In vitro activities of linezolid combined with other antimicrobial agents against Staphylococci, Enterococci, Pneumococci, and selected gram-negative organisms.
Topics: Acetamides; Anti-Bacterial Agents; Drug Antagonism; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; Enterococcus faecalis; Enterococcus faecium; Escherichia coli; Gram-Negative Bacteria; Humans; Klebsiella pneumoniae; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Streptococcus pneumoniae | 2003 |
Linezolid and vancomycin, alone and in combination with rifampin, compared with moxifloxacin against a multidrug-resistant and a vancomycin-tolerant Streptococcus pneumoniae strain in an in vitro pharmacodynamic model.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Drug Tolerance; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Pneumococcal Infections; Rifampin; Streptococcus pneumoniae; Vancomycin; Vancomycin Resistance | 2003 |
Linezolid-resistant, vancomycin-resistant Enterococcus faecium infection in patients without prior exposure to linezolid.
Topics: Acetamides; Aged; Cross Infection; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Vancomycin; Vancomycin Resistance | 2003 |
Occurrence of MRSA endocarditis during linezolid treatment.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Burns; Endocarditis, Bacterial; Follow-Up Studies; Humans; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Risk Assessment; Staphylococcal Infections; Staphylococcus aureus | 2003 |
Linezolid resistance since 2001: SENTRY Antimicrobial Surveillance Program.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Drug Resistance, Bacterial; Female; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Infant; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones | 2003 |
Distribution of tetracycline resistance genes tet(M), tet(O), tet(L) and tet(K) in blood isolates of viridans group streptococci harbouring erm(B) and mef(A) genes. Susceptibility to quinupristin/dalfopristin and linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Blood; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Linezolid; Membrane Proteins; Methyltransferases; Microbial Sensitivity Tests; Oxazolidinones; Polymerase Chain Reaction; Tetracycline Resistance; Virginiamycin; Viridans Streptococci | 2003 |
In vitro activity of new fluoroquinolones and linezolid against non-tuberculous mycobacteria.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Fluoroquinolones; Gatifloxacin; Humans; Levofloxacin; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Ofloxacin; Oxazolidinones; Quinolines; Spain | 2003 |
Emergence of linezolid-resistant Enterococcus faecium during treatment of enterococcal infections.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2003 |
High percentage of methicillin-resistant Staphylococcus aureus isolates with reduced susceptibility to glycopeptides in The Netherlands.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Glycopeptides; Humans; Linezolid; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Netherlands; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2003 |
Comparative in vitro activity of PH-027 versus linezolid and other anti-anaerobic antimicrobials against clinical isolates of Clostridium difficile and other anaerobic bacteria.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria, Anaerobic; Clostridioides difficile; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Triazoles | 2003 |
Challenges with linezolid therapy and reversible pancytopenia.
Topics: Acetamides; Anti-Infective Agents; Female; Humans; Linezolid; Middle Aged; Oxazolidinones; Pancytopenia | 2003 |
In vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, bacitracin, and four other antimicrobials against intestinal anaerobic bacteria.
Topics: Acetamides; Actinomyces; Anti-Bacterial Agents; Bacitracin; Bacteria, Anaerobic; Clostridioides difficile; Depsipeptides; Eubacterium; Feces; In Vitro Techniques; Intestines; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Peptides, Cyclic; Peptostreptococcus; Propionibacterium; Teicoplanin; Vancomycin | 2003 |
Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group.
Topics: Acetamides; Anti-Infective Agents; Bacteria; Chemical Phenomena; Chemistry, Physical; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Structure-Activity Relationship; Sulfonamides | 2003 |
Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients.
Topics: Acetamides; Adult; Anti-Infective Agents; Bone Marrow Transplantation; Drug Therapy, Combination; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome | 2003 |
Staphylococcal scalded skin syndrome.
Topics: Acetamides; Adult; Anti-Infective Agents; Female; Humans; Linezolid; Oxazolidinones; Staphylococcal Scalded Skin Syndrome; Treatment Outcome | 2003 |
Activity of linezolid against anaerobic bacteria.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Bacteroides fragilis; Drug Resistance, Bacterial; Gram-Negative Anaerobic Bacteria; Gram-Positive Bacteria; Humans; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2003 |
Linezolid treatment of total prosthetic knee infection due to methicillin-resistant Staphylococcus epidermidis.
Topics: Acetamides; Anti-Bacterial Agents; Female; Humans; Knee Prosthesis; Linezolid; Methicillin Resistance; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus epidermidis | 2003 |
A validated chiral HPLC method for the enantiomeric separation of Linezolid on amylose based stationary phase.
Topics: Acetamides; Amylose; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Linezolid; Oxazolidinones; Powders; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tablets | 2003 |
Successful use of oral linezolid as a single active agent in endocarditis unresponsive to conventional antibiotic therapy.
Topics: Acetamides; Administration, Oral; Aged; Anti-Bacterial Agents; Endocarditis, Bacterial; Fatal Outcome; Female; Humans; Linezolid; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Treatment Outcome | 2003 |
Failure of intravenous linezolid to treat Clostridium difficile associated diarrhea.
Topics: Acetamides; Anti-Bacterial Agents; Clostridioides difficile; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Microbial; Enterocolitis, Pseudomembranous; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Linezolid; Metronidazole; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Risk Assessment | 2003 |
In vitro and in vivo activities of novel 2-(thiazol-2-ylthio)-1beta-methylcarbapenems with potent activities against multiresistant gram-positive bacteria.
Topics: Abscess; Acetamides; Ampicillin Resistance; Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Carbapenems; Carrier Proteins; Dipeptidases; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Hexosyltransferases; Kidney; Linezolid; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Multienzyme Complexes; Muramoylpentapeptide Carboxypeptidase; Oxazolidinones; Penicillin-Binding Proteins; Peptidyl Transferases; Vancomycin; Vancomycin Resistance | 2003 |
Efficacy of linezolid plus rifampin in an experimental model of methicillin-susceptible Staphylococcus aureus endocarditis.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Colony Count, Microbial; Drug Synergism; Drug Therapy, Combination; Endocarditis, Bacterial; Heart Valves; Kidney; Linezolid; Male; Methicillin; Microbial Sensitivity Tests; Oxazolidinones; Penicillins; Rabbits; Rifampin; Staphylococcal Infections; Staphylococcus aureus | 2003 |
Failure of linezolid treatment for enterococcal endocarditis.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Endocarditis, Bacterial; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Oxazolidinones | 2003 |
Effect of linezolid on the phagocytic functions of human polymorphonuclear leukocytes.
Topics: Acetamides; Anti-Bacterial Agents; Blood Bactericidal Activity; Dose-Response Relationship, Drug; Enterococcus faecalis; Humans; Hydrogen Peroxide; In Vitro Techniques; Linezolid; Methicillin Resistance; Neutrophils; Oxazolidinones; Phagocytosis; Staphylococcus aureus; Superoxides; Vancomycin; Vancomycin Resistance | 2003 |
Pharmacodynamics of linezolid in a clinical isolate of Streptococcus pneumoniae genetically modified to express lux genes.
Topics: Acetamides; Anti-Bacterial Agents; Colony Count, Microbial; Culture Media; Genes, Bacterial; Genetic Markers; Linezolid; Luminescent Measurements; Microbial Sensitivity Tests; Operon; Oxazolidinones; Streptococcus pneumoniae | 2003 |
Linezolid clearance during continuous venovenous hemodiafiltration: a case report.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Anuria; Area Under Curve; Chromatography, High Pressure Liquid; Critical Illness; Drug Administration Schedule; Half-Life; Hemofiltration; Humans; Linezolid; Male; Oxazolidinones | 2003 |
Liver abscess caused by an infected ventriculoperitoneal shunt: doubtful etiology and time for an alternative to vancomycin.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Liver Abscess; Methicillin Resistance; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Vancomycin Resistance; Ventriculoperitoneal Shunt | 2003 |
Real-time monitoring of bacterial infection in vivo: development of bioluminescent staphylococcal foreign-body and deep-thigh-wound mouse infection models.
Topics: Abscess; Acetamides; Animals; Anti-Bacterial Agents; Catheterization; Colony Count, Microbial; Dose-Response Relationship, Drug; Female; Foreign Bodies; Linezolid; Luminescent Measurements; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Thigh; Time Factors; Wound Infection | 2003 |
Efficacy of linezolid alone or in combination with vancomycin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Aortic Valve; Colony Count, Microbial; Drug Synergism; Drug Therapy, Combination; Endocarditis, Bacterial; Female; Kidney; Linezolid; Macrolides; Methicillin Resistance; Oxazolidinones; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2003 |
Resumption of linezolid therapy after myelotoxicity.
Topics: Acetamides; Aged; Bacteremia; Bone Marrow Diseases; Humans; Linezolid; Male; Oxazolidinones | 2003 |
Prophylactic efficacy of linezolid alone or combined with levofloxacin and vancomycin in a rat subcutaneous pouch model of graft infection caused by Staphylococcus epidermidis with intermediate resistance to glycopeptides.
Topics: Acetamides; Animals; Antibiotic Prophylaxis; Drug Resistance, Bacterial; Drug Therapy, Combination; Glycopeptides; Graft Rejection; Levofloxacin; Linezolid; Male; Microbial Sensitivity Tests; Ofloxacin; Oxazolidinones; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus epidermidis; Vancomycin | 2003 |
Mutations in the DNA mismatch repair proteins MutS and MutL of oxazolidinone-resistant or -susceptible Enterococcus faecium.
Topics: Acetamides; Adenosine Triphosphatases; Amino Acid Substitution; Bacterial Proteins; Base Pair Mismatch; Base Sequence; DNA Repair; DNA-Binding Proteins; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecium; Escherichia coli Proteins; Gene Frequency; Genetic Variation; Linezolid; Mutation; MutL Proteins; MutS DNA Mismatch-Binding Protein; Oxazolidinones | 2003 |
Linezolid compared with eperezolid, vancomycin, and gentamicin in an in vitro model of antimicrobial lock therapy for Staphylococcus epidermidis central venous catheter-related biofilm infections.
Topics: Acetamides; Anti-Infective Agents; Biofilms; Catheterization, Central Venous; Catheters, Indwelling; Colony Count, Microbial; Gentamicins; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Sodium Chloride; Staphylococcal Infections; Staphylococcus epidermidis; Vancomycin | 2003 |
Recombination proficiency influences frequency and locus of mutational resistance to linezolid in Enterococcus faecalis.
Topics: Acetamides; Anti-Infective Agents; Blotting, Southern; Drug Resistance, Bacterial; Enterococcus faecalis; Genes, Bacterial; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Point Mutation; Recombination, Genetic; RNA, Ribosomal, 23S | 2003 |
[Successful treatment with linezolid in two cases of methicillin-resistant Staphylococcus aureus infections in the orthopedic field].
Topics: Acetamides; Adult; Anti-Infective Agents; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Orthopedic Procedures; Oxazolidinones; Staphylococcal Infections; Surgical Wound Infection | 2003 |
Use of linezolid in children. Introduction.
Topics: Acetamides; Age Factors; Anti-Infective Agents; Child; Child, Preschool; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Linezolid; Oxazolidinones | 2003 |
Activities of therapeutic agents against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis.
Topics: Acetamides; Adolescent; Amebiasis; Amebicides; Amphotericin B; Animals; Central Nervous System Protozoal Infections; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Ketoconazole; Linezolid; Liposomes; Male; Mice; Minocycline; Naegleria fowleri; Oxazolidinones; Trifluoperazine; Virginiamycin | 2003 |
Development of a liquid chromatography method for the determination of linezolid and its application to in vitro and human microdialysis samples.
Topics: Acetamides; Anti-Infective Agents; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Linezolid; Microdialysis; Oxazolidinones; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Linezolid and serotonin toxicity.
Topics: Acetamides; Humans; Linezolid; Oxazolidinones; Protein Synthesis Inhibitors; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Syndrome | 2003 |
Pharmacology of novel heteroaromatic polycycle antibacterials.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Area Under Curve; Bacterial Infections; Behavior, Animal; Calibration; Cation Transport Proteins; DNA; Dogs; Ether-A-Go-Go Potassium Channels; Female; Heterocyclic Compounds; Linezolid; Male; Mice; Mice, Inbred ICR; Muscle, Skeletal; Mutagens; Neutropenia; Oxazolidinones; Peritonitis; Pneumonia, Pneumococcal; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Binding; Rats; Rats, Sprague-Dawley; Tissue Distribution; Vancomycin | 2003 |
Rapid detection and estimation by pyrosequencing of 23S rRNA genes with a single nucleotide polymorphism conferring linezolid resistance in Enterococci.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus; Genes, Bacterial; Linezolid; Mutation; Oxazolidinones; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Ribosomal, 23S | 2003 |
Activity of AZD2563, a novel oxazolidinone, against Staphylococcus aureus strains with reduced susceptibility to vancomycin or linezolid.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance | 2003 |
Linezolid-associated toxic optic neuropathy: a report of 2 cases.
Topics: Acetamides; Aged; Anti-Infective Agents; Female; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Optic Nerve Diseases; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2003 |
Peritoneal dialysis fluid concentrations of linezolid in the treatment of vancomycin-resistant Enterococcus faecium peritonitis.
Topics: Acetamides; Anti-Bacterial Agents; Dialysis Solutions; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Kidney Failure, Chronic; Linezolid; Male; Middle Aged; Oxazolidinones; Peritoneal Dialysis; Peritonitis; Vancomycin Resistance | 2003 |
Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs.
Topics: Acetamides; Aged; Base Sequence; Cross Infection; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Enterococcus faecalis; Genes, Bacterial; Gram-Positive Bacterial Infections; Hospitalization; Humans; Linezolid; Male; Microbial Sensitivity Tests; Molecular Sequence Data; Oxazolidinones; Polymerase Chain Reaction; Stroke | 2003 |
In vitro activity of newer antibiotics against Corynebacterium jeikeium, Corynebacterium amycolatum and Corynebacterium urealyticum.
Topics: Acetamides; Anti-Bacterial Agents; Corynebacterium; Drug Resistance, Bacterial; In Vitro Techniques; Ketolides; Linezolid; Macrolides; Microbial Sensitivity Tests; Oxazolidinones | 2003 |
Comparative in vitro activity of linezolid and five other antimicrobials against nosocomial isolates of methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis and vancomycin-resistant Enterococcus faecium.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Cross Infection; In Vitro Techniques; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Vancomycin Resistance | 2003 |
Nosocomial pneumonia: therapy is just not good enough.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Cross Infection; Humans; Intensive Care Units; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia, Staphylococcal; Vancomycin | 2003 |
Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Cross Infection; Double-Blind Method; Female; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Randomized Controlled Trials as Topic; Regression Analysis; Vancomycin | 2003 |
Revision of linezolid disk diffusion quality control guidelines for testing Staphylococcus aureus ATCC 25923: an independent seven-laboratory trial.
Topics: Acetamides; Anti-Infective Agents; Humans; Immunodiffusion; Linezolid; Oxazolidinones; Quality Control; Staphylococcal Infections; Staphylococcus aureus | 2003 |
New TB antibiotic.
Topics: Acetamides; Adolescent; Adult; Antitubercular Agents; Child; Clinical Trials as Topic; Drug Resistance, Bacterial; Female; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Tuberculosis, Pulmonary | 2003 |
Influence of ethylene-oxy spacer group on the activity of linezolid: synthesis of potent antibacterials possessing a thiocarbonyl group.
Topics: Acetamides; Anti-Infective Agents; Bacteria; Ethylenes; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Structure-Activity Relationship; Thioacetamide | 2003 |
Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Structure-Activity Relationship | 2003 |
The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Phenols; Rats; Structure-Activity Relationship; Thiadiazoles; Thioacetamide | 2003 |
Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Benzazepines; Gram-Negative Bacteria; Gram-Positive Bacteria; Linezolid; Mice; Microbial Sensitivity Tests; Oxazolidinones; Structure-Activity Relationship | 2003 |
Novel oxazolidinone-quinolone hybrid antimicrobials.
Topics: Acetamides; Anti-Bacterial Agents; Ciprofloxacin; DNA Topoisomerase IV; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Quinolones; Structure-Activity Relationship | 2003 |
Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action.
Topics: Acetamides; Anti-Bacterial Agents; DNA Topoisomerase IV; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Quinolones; Structure-Activity Relationship | 2003 |
Linezolid: the first oxazolidinone antimicrobial.
Topics: Acetamides; Anti-Infective Agents; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Prescription Fees | 2003 |
Linezolid: the first oxazolidinone antimicrobial.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2003 |
Linezolid: the first oxazolidinone antimicrobial.
Topics: Acetamides; Anti-Infective Agents; Clinical Trials as Topic; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2003 |
Bactericidal activities of daptomycin, quinupristin-dalfopristin, and linezolid against vancomycin-resistant Staphylococcus aureus in an in vitro pharmacodynamic model with simulated endocardial vegetations.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Colony Count, Microbial; Culture Media; Daptomycin; Drug Therapy, Combination; Endocardium; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance; Virginiamycin | 2003 |
Clinical pharmacodynamics of linezolid in seriously ill patients treated in a compassionate use programme.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Area Under Curve; Comorbidity; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Liver; Logistic Models; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2003 |
Stability indicating HPTLC determination of linezolid as bulk drug and in pharmaceutical dosage form.
Topics: Acetamides; Anti-Infective Agents; Chemistry, Pharmaceutical; Chromatography, Thin Layer; Hydrolysis; Linezolid; Materials Testing; Oxazolidinones; Oxidation-Reduction; Photochemistry | 2003 |
Delayed discovery of linezolid-resistant, vancomycin-resistant Enterococcus faecium: lessons learned.
Topics: Acetamides; Aged; Aged, 80 and over; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Vancomycin; Vancomycin Resistance | 2004 |
In vitro activities of DA-7867, a novel oxazolidinone, against recent clinical isolates of aerobic and anaerobic bacteria.
Topics: Acetamides; Anti-Infective Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Bacteroides; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Negative Bacteria; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Vancomycin Resistance | 2004 |
Linezolid, levofloxacin, and vancomycin against vancomycin-tolerant and fluoroquinolone-resistant Streptococcus pneumoniae in an in vitro pharmacodynamic model.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Levofloxacin; Linezolid; Microbial Sensitivity Tests; Ofloxacin; Oxazolidinones; Streptococcus pneumoniae; Vancomycin | 2003 |
Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin.
Topics: Acetamides; Cohort Studies; Cost-Benefit Analysis; Drug Costs; Female; Hospital Costs; Humans; Intensive Care Units; Linezolid; Male; Oxazolidinones; Pneumonia, Aspiration; Pneumonia, Staphylococcal; Quality-Adjusted Life Years; Respiration, Artificial; Respiratory Distress Syndrome; United States; Vancomycin; Ventilators, Mechanical | 2004 |
Clinical cure and survival in Gram-positive ventilator-associated pneumonia: retrospective analysis of two double-blind studies comparing linezolid with vancomycin.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Cross Infection; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Logistic Models; Male; Middle Aged; Oxazolidinones; Pneumonia, Bacterial; Respiration, Artificial; Retrospective Studies; Survival Analysis; Survival Rate; Vancomycin | 2004 |
Subinhibitory concentrations of linezolid reduce Staphylococcus aureus virulence factor expression.
Topics: Acetamides; Animals; Anti-Infective Agents; Bacterial Proteins; Blotting, Western; Chromatography, Liquid; Databases, Genetic; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Exotoxins; Gene Expression Regulation, Bacterial; Linezolid; Mass Spectrometry; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Oxazolidinones; Peptides; Protein Hydrolysates; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spleen; Staphylococcus aureus; Trypsin; Tumor Necrosis Factor-alpha; Virulence Factors | 2004 |
Acute delirium associated with combined diphenhydramine and linezolid use.
Topics: Acetamides; Acute Disease; Delirium; Diphenhydramine; Drug Combinations; Drug Interactions; Duty to Warn; Hallucinations; Humans; Injections, Intravenous; Linezolid; Male; Middle Aged; Oxazolidinones; Pruritus; Risperidone; Time Factors; Vancomycin | 2004 |
Antibiotics as an adjunct to surgical management of lower extremity ulcerations.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Daptomycin; Debridement; Diabetic Foot; Drug Resistance, Microbial; Female; Foot Ulcer; Glycopeptides; Humans; Leg Ulcer; Linezolid; Lipoglycopeptides; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Wound Healing | 2004 |
[Sensitivity of methicillin resistant staphylococci to linezolid and some other antimicrobial agents].
Topics: Acetamides; Anti-Infective Agents; Ciprofloxacin; Clindamycin; Drug Resistance, Bacterial; Erythromycin; Gentamicins; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin | 2003 |
Cost analysis of switching from i.v. vancomycin to p.o. linezolid for the management of methicillin-resistant Staphylococcus species.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents; Costs and Cost Analysis; Female; Hospitals, Veterans; Humans; Injections, Intravenous; Linezolid; Los Angeles; Male; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Vancomycin | 2003 |
Treatment outcomes for serious infections caused by methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Humans; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin; Vancomycin Resistance | 2004 |
Treatment of meningitis due to methicillin-resistant Staphylococcus epidermidis with linezolid.
Topics: Accidents, Traffic; Acetamides; Adolescent; Anti-Infective Agents; Community-Acquired Infections; Female; Humans; Linezolid; Meningitis, Bacterial; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis | 2004 |
Linezolid in VAP by MRSA: a better choice?
Topics: Acetamides; Anti-Infective Agents; Cross Infection; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia, Staphylococcal; Respiration, Artificial; Vancomycin | 2004 |
Simple method for the assay of linezolid in Brain Heart Infusion broth by high-performance liquid chromatography.
Topics: Acetamides; Anti-Infective Agents; Chromatography, High Pressure Liquid; Culture Media; Linezolid; Oxazolidinones; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2004 |
Mutant prevention concentration: comparison of fluoroquinolones and linezolid with Mycobacterium tuberculosis.
Topics: Acetamides; Anti-Infective Agents; Area Under Curve; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis | 2004 |
An approach to enhance specificity against RNA targets using heteroconjugates of aminoglycosides and chloramphenicol (or linezolid).
Topics: Acetamides; Aminoglycosides; Chloramphenicol; Framycetin; Linezolid; Nucleic Acid Conformation; Oxazolidinones; RNA; Structure-Activity Relationship; Substrate Specificity | 2004 |
First report of a linezolid-resistant vancomycin-resistant Enterococcus faecium strain in Greece.
Topics: Acetamides; Adult; Enterococcus faecium; Greece; Humans; Linezolid; Male; Oxazolidinones; Vancomycin Resistance | 2004 |
Linezolid-induced neuropathy.
Topics: Acetamides; Adult; Anti-Infective Agents; Female; Humans; Linezolid; Oxazolidinones; Peripheral Nervous System Diseases | 2004 |
In vitro post-antibiotic effect of fluoroquinolones, macrolides, beta-lactams, tetracyclines, vancomycin, clindamycin, linezolid, chloramphenicol, quinupristin/dalfopristin and rifampicin on Bacillus anthracis.
Topics: Acetamides; Anti-Bacterial Agents; Bacillus anthracis; beta-Lactams; Chloramphenicol; Clindamycin; Fluoroquinolones; Linezolid; Macrolides; Microbial Sensitivity Tests; Oxazolidinones; Rifampin; Tetracyclines; Vancomycin; Virginiamycin | 2004 |
In vitro activities of Daptomycin, Linezolid, and Quinupristin-Dalfopristin against a challenge panel of Staphylococci and Enterococci, including vancomycin-intermediate staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Daptomycin; Drug Therapy, Combination; Enterococcus faecium; Genes, Bacterial; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Vancomycin Resistance; Virginiamycin | 2003 |
Activity of linezolid against Gram-positive cocci isolated in French hospitals as determined by three in-vitro susceptibility testing methods.
Topics: Acetamides; Anti-Infective Agents; Enterococcus; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Streptococcus | 2004 |
[Treatment of multiresistant Staphylococcus epidermidis meningitis with linezolid].
Topics: Acetamides; Adolescent; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Male; Meningitis, Bacterial; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis | 2004 |
[Linezolide and urinary tract infection].
Topics: Acetamides; Anti-Infective Agents; Gram-Positive Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Urinary Tract Infections | 2004 |
Efficacy of dalbavancin against methicillin-resistant Staphylococcus aureus in the rat granuloma pouch infection model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Female; Glycopeptides; Granuloma; Injections, Intramuscular; Injections, Intravenous; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Rats; Rats, Sprague-Dawley; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Vancomycin | 2004 |
Antimicrobials in the treatment of orthopaedic prosthetic infections.
Topics: Acetamides; Anti-Infective Agents; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Prosthesis-Related Infections | 2004 |
Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Female; Fetal Blood; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Stem Cell Transplantation | 2004 |
Current and new antimicrobial agents.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Glycopeptides; Gram-Positive Bacterial Infections; Humans; Linezolid; Lipoglycopeptides; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Virginiamycin | 2004 |
Comparative activity of telithromycin against macrolide-resistant isolates of Streptococcus pneumoniae: results of two years of the PROTEKT surveillance study.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Ketolides; Linezolid; Macrolides; Oxazolidinones; Pneumococcal Infections; Population Surveillance; Streptococcus pneumoniae; Vancomycin | 2004 |
Linezolid-induced bradycardia: a case report.
Topics: Acetamides; Anti-Infective Agents; Bradycardia; Escherichia coli Infections; Female; Fever; Humans; Jaundice; Linezolid; Middle Aged; Oxazolidinones | 2004 |
Clinical experience with linezolid in conjunction with wound coverage techniques for skin and soft-tissue infections and postoperative osteomyelitis.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Debridement; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Osteomyelitis; Oxazolidinones; Postoperative Complications; Skin Transplantation; Soft Tissue Infections; Staphylococcus aureus; Surgical Flaps; Surgical Procedures, Operative; Treatment Outcome; Vancomycin Resistance; Wounds and Injuries | 2004 |
Similar hematologic effects of long-term linezolid and vancomycin therapy in a prospective observational study of patients with orthopedic infections.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Infective Agents; Drug Combinations; Female; Gram-Positive Bacterial Infections; Hematologic Diseases; Humans; Linezolid; Male; Middle Aged; Orthopedics; Oxazolidinones; Postoperative Complications; Prospective Studies; Thrombocytopenia; Time; Vancomycin | 2004 |
Hematologic effects of linezolid versus vancomycin.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Hematologic Diseases; Humans; Linezolid; Oxazolidinones; Thrombocytopenia; Vancomycin | 2004 |
Successful treatment of Staphylococcus epidermidis hip prosthesis infection with oral linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Female; Hip Prosthesis; Humans; Linezolid; Methicillin Resistance; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis | 2004 |
Severe bilateral optic neuritis associated with prolonged linezolid therapy.
Topics: Acetamides; Aged; Anti-Infective Agents; Antibiotics, Antitubercular; Ciprofloxacin; Female; Functional Laterality; Humans; Linezolid; Optic Neuritis; Oxazolidinones; Prosthesis-Related Infections; Rifampin | 2004 |
Successful treatment of disseminated cerebritis complicating methicillin-resistant Staphylococcus aureus Endocarditis unresponsive to vancomycin therapy with linezolid.
Topics: Acetamides; Bacteremia; Community-Acquired Infections; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Endocarditis, Bacterial; Follow-Up Studies; Humans; Infusions, Intravenous; Linezolid; Male; Meningitis, Listeria; Methicillin Resistance; Middle Aged; Oxazolidinones; Risk Assessment; Severity of Illness Index; Staphylococcal Infections; Tomography, X-Ray Computed; Treatment Outcome; Vancomycin | 2004 |
Linezolid and quinupristin/dalfopristin resistance in vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus prior to clinical use in Turkey.
Topics: Acetamides; Anti-Bacterial Agents; Blood; Cerebrospinal Fluid; Drug Resistance, Bacterial; Enterococcus; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Rectum; Respiratory System; Staphylococcal Infections; Staphylococcus aureus; Turkey; Vancomycin Resistance; Virginiamycin; Wounds and Injuries | 2004 |
Further method development for measurement of linezolid in human serum by MEKC.
Topics: Acetamides; Chromatography, Micellar Electrokinetic Capillary; Humans; Linezolid; Oxazolidinones | 2004 |
Serotonin syndrome due to co-administration of linezolid and venlafaxine.
Topics: Acetamides; Aged; Anti-Infective Agents; Cyclohexanols; Drug Interactions; Drug Resistance, Bacterial; Hip Prosthesis; Humans; Linezolid; Male; Oxazolidinones; Prosthesis-Related Infections; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Venlafaxine Hydrochloride | 2004 |
Effects of linezolid on staphylococcal adherence versus time of treatment.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Adhesion; Cross Infection; Humans; In Vitro Techniques; Linezolid; Microscopy, Electron, Scanning; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Time Factors; Vancomycin | 2004 |
Linezolid-resistant Enterococcus faecium and Enterococcus faecalis isolated from a septic patient: report of first isolates in Germany.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Fatal Outcome; Female; Germany; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Pancreatitis, Acute Necrotizing; Peritonitis; Shock, Septic | 2004 |
Unresolved questions with the use of linezolid vs vancomycin for nosocomial pneumonia.
Topics: Acetamides; Cross Infection; Female; Follow-Up Studies; Humans; Linezolid; Male; Oxazolidinones; Pneumonia, Bacterial; Risk Assessment; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2004 |
Macrolide resistance phenotypes of commensal viridans group streptococci and Gemella spp. and PCR detection of resistance genes.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance; Erythromycin; Genes, Bacterial; Humans; Ketolides; Lincosamides; Linezolid; Macrolides; Membrane Proteins; Methyltransferases; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcaceae; Streptogramin B; Tetracycline Resistance; Virginiamycin; Viridans Streptococci | 2004 |
Susceptibility to quinupristin-dalfopristin and linezolid in 839 clinical isolates of Gram-positive cocci from Norway.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Norway; Oxazolidinones; Virginiamycin | 2004 |
[A case of invasive group A Streptococcus infection which was successfully treated with linezolid].
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Male; Middle Aged; Myositis; Oxazolidinones; Streptococcal Infections; Streptococcus pyogenes | 2004 |
Serotonin syndrome and linezolid.
Topics: Acetamides; Anti-Infective Agents; Burns; Child, Preschool; Depression; Drug Interactions; Female; Fluoxetine; Humans; Linezolid; Monoamine Oxidase Inhibitors; Oxazolidinones; Serotonin Syndrome | 2004 |
Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.
Topics: Acetamides; Anti-Infective Agents; Blood; Blotting, Southern; Chromosomes, Bacterial; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Gene Deletion; Gene Dosage; Genes, rRNA; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Point Mutation; RNA, Bacterial; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus aureus | 2004 |
Successful treatment of methicillin-resistant Staphylococcus aureus endocarditis with linezolid.
Topics: Acetamides; Anti-Infective Agents; Endocarditis, Bacterial; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2004 |
Linezolid-associated peripheral neuropathy.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Humans; Linezolid; Male; Oxazolidinones; Peripheral Nervous System Diseases; Surgical Wound Infection | 2004 |
Linezolid and vancomycin for methicillin-resistant Staphylococcus aureus nosocomial pneumonia: the subtleties of subgroup analyses.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Cross Infection; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia, Staphylococcal; Randomized Controlled Trials as Topic; Vancomycin | 2004 |
Pharmacodynamics of telavancin (TD-6424), a novel bactericidal agent, against gram-positive bacteria.
Topics: Acetamides; Aminoglycosides; Animals; Anti-Bacterial Agents; Area Under Curve; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Endpoint Determination; Female; Gram-Positive Bacterial Infections; Linezolid; Lipoglycopeptides; Methicillin Resistance; Mice; Muscle, Skeletal; Nafcillin; Neutropenia; Oxazolidinones; Protein Binding; Staphylococcal Infections; Subcutaneous Tissue; Vancomycin | 2004 |
Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides.
Topics: Acetamides; Animals; Anti-Infective Agents; Antimicrobial Cationic Peptides; Blood Vessel Prosthesis; Colony Count, Microbial; Drug Resistance, Bacterial; Drug Synergism; Glycopeptides; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Pharmaceutical Solutions; Polyethylene Terephthalates; Prosthesis-Related Infections; Proteins; Rats; Staphylococcal Infections; Staphylococcus epidermidis | 2004 |
In vitro activities of telithromycin, linezolid, and quinupristin-dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations.
Topics: Acetamides; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Humans; Ketolides; Linezolid; Macrolides; Mutation; Oxazolidinones; Pneumococcal Infections; Ribosomes; RNA, Ribosomal, 23S; Streptococcus pneumoniae; Virginiamycin | 2004 |
Prediction of clinical pharmacokinetic parameters of linezolid using animal data by allometric scaling: applicability for the development of novel oxazolidinones.
Topics: Acetamides; Animals; Body Size; Dogs; Drug Design; Half-Life; Humans; Linezolid; Male; Mice; Models, Animal; Oxazolidinones; Rats; Rats, Wistar | 2004 |
Elimination of linezolid by an in vitro extracorporeal circuit model.
Topics: Acetamides; Acrylic Resins; Anti-Infective Agents; Biocompatible Materials; Extracorporeal Circulation; Hemodiafiltration; Humans; In Vitro Techniques; Linezolid; Membranes, Artificial; Models, Biological; Nylons; Oxazolidinones; Polymers; Renal Insufficiency; Sulfones; Surface Properties | 2004 |
Causal relationship between neuropathy and prolonged linezolid use.
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Optic Nerve Diseases; Oxazolidinones; Peripheral Nervous System Diseases | 2004 |
Treatment of vancomycin-intermediate Staphylcoccus aureus endocarditis with linezolid.
Topics: Acetamides; Amikacin; Anti-Infective Agents; Aortic Valve; Drug Resistance, Bacterial; Drug Therapy, Combination; Endocarditis, Bacterial; Heart Valve Prosthesis; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin | 2004 |
Comment on: Serotonin syndrome due to co-administration of linezolid and venlafaxine.
Topics: Acetamides; Anti-Bacterial Agents; Cyclohexanols; Drug Synergism; Humans; Linezolid; Oxazolidinones; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Venlafaxine Hydrochloride | 2004 |
Reversal of linezolid-associated cytopenias, but not peripheral neuropathy, by administration of vitamin B6.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Blood Cell Count; Female; Humans; Linezolid; Male; Middle Aged; Mycobacterium Infections; Oxazolidinones; Pancytopenia; Peripheral Nervous System Diseases; Treatment Outcome; Vitamin B 6 | 2004 |
Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristin.
Topics: Acetamides; Anti-Bacterial Agents; Drug Utilization; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Point Mutation; RNA, Bacterial; RNA, Ribosomal, 23S; Vancomycin Resistance; Virginiamycin | 2004 |
Risk factors for anaemia in patients on prolonged linezolid therapy for chronic osteomyelitis: a case-control study.
Topics: Acetamides; Administration, Oral; Adult; Aged; Aged, 80 and over; Anemia; Anti-Bacterial Agents; Case-Control Studies; Chronic Disease; Drug Administration Schedule; Female; Gram-Positive Bacterial Infections; Humans; Injections, Intravenous; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones; Retrospective Studies; Risk Factors | 2004 |
In vitro activity of telithromycin, quinupristin/dalfopristin, linezolid and comparator antimicrobial agents against Staphylococcus aureus clinical isolates.
Topics: Acetamides; Drug Resistance, Multiple, Bacterial; Humans; Ketolides; Linezolid; Macrolides; Microbial Sensitivity Tests; Oxazolidinones; Sampling Studies; Sensitivity and Specificity; Spain; Staphylococcus aureus; Virginiamycin | 2004 |
Synthesis and antibacterial evaluation of oxazolidin-2-ones structurally related to linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Structure-Activity Relationship | 2004 |
Reversion to susceptibility in a linezolid-resistant clinical isolate of Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Genes, Bacterial; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Staphylococcus aureus | 2004 |
Linezolid therapy for orthopedic infections.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Bone Diseases, Infectious; Databases, Factual; Debridement; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Minnesota; Oxazolidinones; Retrospective Studies; Treatment Outcome | 2004 |
Novel tetrahydro-thieno pyridyl oxazolidinone: an antibacterial agent.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus faecalis; Linezolid; Methicillin; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Pyridines; Staphylococcus aureus; Structure-Activity Relationship; Vancomycin | 2004 |
Activity of daptomycin against multi-resistant Gram-positive bacteria including enterococci and Staphylococcus aureus resistant to linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Daptomycin; Drug Resistance, Bacterial; Drug Resistance, Multiple; Enterococcus; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Staphylococcus aureus | 2004 |
In vivo efficacy of linezolid in combination with gentamicin for the treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Infective Agents; Disease Models, Animal; Drug Resistance, Bacterial; Drug Therapy, Combination; Endocarditis, Bacterial; Gentamicins; Linezolid; Methicillin; Microbial Sensitivity Tests; Oxazolidinones; Rabbits; Staphylococcus aureus | 2004 |
Sideroblastic anemia due to linezolid in a patient with a left ventricular assist device.
Topics: Acetamides; Anemia, Sideroblastic; Anti-Infective Agents; Heart Transplantation; Heart-Assist Devices; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus epidermidis; Waiting Lists | 2004 |
Eradication of pulmonary methicillin-resistant staphylococcus aureus (MRSA) in cystic fibrosis with linezolid.
Topics: Acetamides; Administration, Oral; Adult; Cystic Fibrosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Humans; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2004 |
[Resistance to linezolid in Staphylococcus aureus before its release].
Topics: Acetamides; Aged; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus | 2004 |
Enterococcal bacteremia complicating pemphigus vulgaris: successful treatment with linezolid.
Topics: Acetamides; Adult; Bacteremia; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Follow-Up Studies; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Pemphigus; Severity of Illness Index; Treatment Outcome | 2004 |
Action of fluoroquinolones and Linezolid on logarithmic- and stationary-phase culture of Mycobacterium tuberculosis.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Culture Media; Drug Resistance, Bacterial; Fluoroquinolones; Gatifloxacin; Hydrogen-Ion Concentration; Levofloxacin; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Mycobacterium tuberculosis; Ofloxacin; Oxazolidinones; Quinolines; Rifampin; Structure-Activity Relationship; Time Factors | 2004 |
Molecular detection of linezolid resistance in Enterococcus faecium and Enterococcus faecalis by use of 5' nuclease real-time PCR compared to a modified classical approach.
Topics: Acetamides; Alleles; Anti-Infective Agents; DNA, Bacterial; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Humans; Linezolid; Oligonucleotide Array Sequence Analysis; Oxazolidinones; Polymerase Chain Reaction; RNA, Ribosomal, 23S; Taq Polymerase | 2004 |
Mycobacterium chelonae infection successfully treated with oral clarithromycin and linezolid.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Clarithromycin; Drug Therapy, Combination; Female; Forearm; Humans; Linezolid; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Opportunistic Infections; Oxazolidinones; Skin Diseases, Bacterial | 2004 |
Treatment with linezolid and rifampicin for 18 months for recurrent infection of a megaprosthesis in a patient with Ewing's sarcoma.
Topics: Acetamides; Adult; Bacterial Infections; Drug Resistance, Bacterial; Female; Humans; Linezolid; Oxazolidinones; Prosthesis-Related Infections; Rifampin; Sarcoma, Ewing | 2004 |
Determination of linezolid in plasma and bronchoalveolar lavage by high-performance liquid chromatography with ultraviolet detection using a fully automated extraction method.
Topics: Acetamides; Anti-Bacterial Agents; Automation; Bronchoalveolar Lavage Fluid; Calibration; Chromatography, High Pressure Liquid; Humans; Linezolid; Oxazolidinones; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2004 |
Linezolid disposition after standard dosages in critically ill patients undergoing continuous venovenous hemofiltration: a report of 2 cases.
Topics: Acetamides; Aged; Drug Administration Schedule; Gram-Positive Bacterial Infections; Hemofiltration; Humans; Infusions, Intravenous; Kidney Failure, Chronic; Linezolid; Male; Middle Aged; Oxazolidinones; Peritonitis; Surgical Wound Infection | 2004 |
Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model.
Topics: Acetamides; Anti-Bacterial Agents; Area Under Curve; Culture Media; Daptomycin; Drug Resistance, Bacterial; Drug Therapy, Combination; Endocarditis, Bacterial; Gentamicins; Half-Life; Kinetics; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Nafcillin; Oxazolidinones; Penicillins; Staphylococcus aureus; Vancomycin | 2004 |
Linezolid-bupropion interaction as possible etiology of severe intermittent intraoperative hypertension?
Topics: Acetamides; Anti-Infective Agents; Bupropion; Dopamine Uptake Inhibitors; Humans; Hypertension; Intraoperative Complications; Linezolid; Oxazolidinones | 2004 |
Successful treatment of vancomycin-resistant Enterococcus faecium endocarditis with linezolid in a renal transplant recipient with human immunodeficiency virus infection.
Topics: Acetamides; Anti-Infective Agents; Endocarditis, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; HIV Infections; Humans; Kidney Transplantation; Linezolid; Male; Middle Aged; Opportunistic Infections; Oxazolidinones; Vancomycin Resistance; Viral Load | 2004 |
In vitro activities of cefotaxime, vancomycin, quinupristin/dalfopristin, linezolid and other antibiotics alone and in combination against Propionibacterium acnes isolates from central nervous system infections.
Topics: Acetamides; Cefotaxime; Central Nervous System Infections; Drug Therapy, Combination; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Propionibacterium acnes; Vancomycin; Virginiamycin | 2005 |
Linezolid.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Child; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Protein Biosynthesis; Protein Synthesis Inhibitors | 2004 |
Removal of linezolid by conventional intermittent hemodialysis, sustained low-efficiency dialysis, or continuous venovenous hemofiltration in patients with acute renal failure.
Topics: Acetamides; Acute Kidney Injury; Aged; Aged, 80 and over; APACHE; Chromatography, High Pressure Liquid; Critical Care; Dialysis; Female; Follow-Up Studies; Hemofiltration; Humans; Injections, Intravenous; Intensive Care Units; Linezolid; Male; Middle Aged; Oxazolidinones; Prospective Studies; Renal Dialysis; Risk Assessment; Severity of Illness Index | 2004 |
Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones.
Topics: Acetamides; Anti-Infective Agents; Bacteria; Benzimidazoles; Benzoxazoles; Isomerism; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Structure-Activity Relationship; Thioacetamide; Triazoles | 2005 |
In vitro and in vivo synergistic activities of linezolid combined with subinhibitory concentrations of imipenem against methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Infective Agents; Colony Count, Microbial; Drug Synergism; Endocarditis, Bacterial; Female; Humans; Imipenem; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Rabbits; Staphylococcal Infections; Staphylococcus aureus | 2005 |
[Prolonged treatment with linezolid with good hematologic tolerability].
Topics: Acetamides; Aged; Anti-Infective Agents; Blood Platelets; Enterococcus faecalis; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Middle Aged; Oxazolidinones; Staphylococcal Infections; Time Factors | 2004 |
[Linezolid, an agent from a new class of antibiotics].
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Treatment Outcome; Tuberculosis | 2004 |
In vitro activity of vancomycin, quinupristin/dalfopristin, and linezolid against intact and disrupted biofilms of staphylococci.
Topics: Acetamides; Biofilms; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Staphylococcus aureus; Staphylococcus epidermidis; Vancomycin; Virginiamycin | 2005 |
Surveillance of linezolid resistance in Germany, 2001-2002.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Bacterial; Female; Germany; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Population Surveillance | 2005 |
[Expensive modern therapy options in intensive care medicine in Germany-- are they being used? Results of a questionnaire].
Topics: Acetamides; Anti-Infective Agents; Critical Care; Cross Infection; Drug Utilization; Factor VIIa; Germany; Hemorrhage; Humans; Intensive Care Units; Linezolid; Methicillin Resistance; Oxazolidinones; Protein C; Recombinant Proteins; Sepsis; Staphylococcal Infections; Staphylococcus aureus; Surveys and Questionnaires | 2005 |
In vitro activity of linezolid & quinupristin/dalfopristin against Gram-positive cocci.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Turkey; Virginiamycin | 2004 |
In-vitro activity of linezolid against clinical isolates of Gram-positive cocci in a tertiary care hospital.
Topics: Acetamides; Anti-Infective Agents; Bacterial Infections; Drug Resistance, Multiple, Bacterial; Gram-Positive Cocci; Hospitals; Humans; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2004 |
Syntheses and antibacterial activity of a series of 3-(pyridine-3-yl)-2-oxazolidinone.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Pyridines; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus | 2005 |
Emerging linezolid-resistant, vancomycin resistant Enterococcus faecium from a patient of a haematological unit in Poland.
Topics: Acetamides; Adult; Drug Resistance, Bacterial; Enterococcus faecium; Humans; Linezolid; Male; Mutation; Oxazolidinones; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Vancomycin Resistance | 2004 |
Linezolid in the treatment of Gram-positive prosthetic joint infections.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Gram-Positive Bacterial Infections; Hip Prosthesis; Humans; Joint Diseases; Knee Prosthesis; Linezolid; Male; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Retrospective Studies | 2005 |
First linezolid- and vancomycin-resistant Enterococcus faecium strain in Taiwan.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Middle Aged; Oxazolidinones; Taiwan; Vancomycin | 2005 |
Treatment of brain abscess caused by Listeria monocytogenes in a patient with allergy to penicillin and trimethoprim-sulfamethoxazole.
Topics: Acetamides; Ampicillin; Anti-Bacterial Agents; Brain Abscess; Drug Hypersensitivity; Drug Therapy, Combination; Humans; Linezolid; Listeriosis; Male; Middle Aged; Oxazolidinones; Rifampin; Trimethoprim, Sulfamethoxazole Drug Combination | 2005 |
Usefulness of various antibiotics against Mycobacterium avium-intracellulare, measured by their mutant prevention concentration.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Linezolid; Macrolides; Microbial Sensitivity Tests; Mutation; Mycobacterium avium Complex; Oxazolidinones; Selection, Genetic | 2005 |
No mercy for MRSA: treatment alternatives to vancomycin and linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Humans; Liability, Legal; Linezolid; Methicillin Resistance; Oxazolidinones; Rifampin; Staphylococcal Infections; Staphylococcus aureus; United States; Vancomycin | 2005 |
Successful treatment with linezolid of septic shock secondary to methicillin-resistant Staphylococcus aureus arthritis.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Arthritis, Infectious; Humans; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Shock, Septic; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2005 |
Linezolid pharmacokinetics in an obese patient.
Topics: Acetamides; Adult; Anti-Infective Agents; Cellulitis; Half-Life; Humans; Linezolid; Male; Metabolic Clearance Rate; Obesity; Oxazolidinones | 2005 |
[The first experience with linezolide in treatment of nosocomial septic condition in premature neonates].
Topics: Acetamides; Anti-Bacterial Agents; Coagulase; Cross Infection; Humans; Infant, Newborn; Infant, Premature, Diseases; Linezolid; Oxazolidinones; Sepsis; Staphylococcal Infections; Staphylococcus | 2004 |
Severe sensory neuropathy associated with long-term linezolid use.
Topics: Acetamides; Adult; Anti-Infective Agents; Drug Administration Schedule; Female; Ganglia, Spinal; Humans; Linezolid; Muscle Weakness; Neuralgia; Neurons, Afferent; Neurotoxins; Optic Nerve; Osteomyelitis; Oxazolidinones; Peripheral Nerves; Peripheral Nervous System Diseases; Sensation Disorders; Somatosensory Disorders; Staphylococcal Infections; Time Factors; Vision Disorders | 2005 |
Optic neuropathy associated with linezolid treatment.
Topics: Acetamides; Aged; Anti-Infective Agents; Evoked Potentials, Visual; Female; Fundus Oculi; Humans; Linezolid; Optic Nerve Diseases; Oxazolidinones; Visual Acuity; Visual Fields | 2005 |
Linezolid use associated with lactic acidosis.
Topics: Acetamides; Acidosis, Lactic; Aged; Anti-Infective Agents; Bacteremia; Diagnosis, Differential; Humans; Linezolid; Lymphoma, T-Cell, Cutaneous; Male; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections | 2005 |
Ventriculitis due to a hetero strain of vancomycin intermediate Staphylococcus aureus (hVISA): successful treatment with linezolid in combination with intraventricular vancomycin.
Topics: Acetamides; Aged; Cerebral Ventricles; Drug Resistance, Bacterial; Drug Therapy, Combination; Encephalitis; Humans; Linezolid; Male; Oxazolidinones; South Africa; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2005 |
Susceptibility of methicillin-resistant Staphylococcus aureus to vancomycin, teicoplanin, linezolid, pristinamycin and other antibiotics.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Pristinamycin; Staphylococcus aureus; Teicoplanin; Vancomycin | 2005 |
Efficacy of current agents used in the treatment of Gram-positive infections and the consequences of resistance.
Topics: Acetamides; Anti-Infective Agents; Cross Infection; Daptomycin; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2005 |
Antibacterial activity of linezolid and vancomycin in an in vitro pharmacodynamic model of gram-positive catheter-related bacteraemia.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Biofilms; Catheterization, Central Venous; Colony Count, Microbial; Enterococcus faecium; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Models, Biological; Oxazolidinones; Staphylococcus aureus; Staphylococcus epidermidis; Vancomycin | 2005 |
In vitro activity of linezolid, clarithromycin and moxifloxacin against clinical isolates of Mycobacterium kansasii.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Clarithromycin; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Mycobacterium kansasii; Oxazolidinones; Quinolines | 2005 |
Anaerobic sepsis due to multidrug-resistant Bacteroides fragilis: microbiological cure and clinical response with linezolid therapy.
Topics: Acetamides; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infections; Drug Resistance, Multiple, Bacterial; Female; Humans; Linezolid; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Sepsis | 2005 |
Coagulase-negative staphylococcal meningitis in adults: clinical characteristics and therapeutic outcomes.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Meningitis, Bacterial; Middle Aged; Oxacillin; Oxazolidinones; Penicillin Resistance; Retrospective Studies; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2005 |
Methicillin-resistant Staphylococcus aureus infection in liver transplantation: a matched controlled study.
Topics: Acetamides; Female; Humans; Incidence; Intensive Care Units; Length of Stay; Linezolid; Liver Transplantation; Male; Methicillin Resistance; Oxazolidinones; Postoperative Complications; Retrospective Studies; Staphylococcal Infections; Survival Analysis; Vancomycin | 2005 |
Successful treatment of Staphylococcus epidermidis prosthetic valve endocarditis with linezolid after failure of treatment with oxacillin, gentamicin, rifampicin, vancomycin, and fusidic acid regimens.
Topics: Acetamides; Anti-Infective Agents; Drug Therapy, Combination; Endocarditis, Bacterial; Heart Valve Prosthesis; Humans; Linezolid; Male; Middle Aged; Mitral Valve; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus epidermidis; Treatment Failure; Treatment Outcome | 2005 |
In vitro activity of daptomycin versus linezolid and vancomycin against gram-positive uropathogens and ampicillin against enterococci, causing complicated urinary tract infections.
Topics: Acetamides; Ampicillin; Anti-Bacterial Agents; Cross Infection; Daptomycin; Enterococcus; Genotype; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Urinary Tract Infections; Vancomycin | 2005 |
[Linezolid-related leukocytoclastic vasculitis].
Topics: Acetamides; Aged; Anti-Bacterial Agents; Humans; Linezolid; Male; Oxazolidinones; Vasculitis, Leukocytoclastic, Cutaneous | 2005 |
Trends in linezolid susceptibility patterns in 2002: report from the worldwide Zyvox Annual Appraisal of Potency and Spectrum Program.
Topics: Acetamides; Anti-Infective Agents; Asia; Drug Resistance, Bacterial; Europe; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Latin America; Linezolid; Microbial Sensitivity Tests; North America; Oxazolidinones; Population Surveillance; South America | 2005 |
Activity of RBx 7644 and RBx 8700, new investigational oxazolidinones, against Mycobacterium tuberculosis infected murine macrophages.
Topics: Acetamides; Animals; Antitubercular Agents; Cell Line; Drug Antagonism; Furans; Isoniazid; Linezolid; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxazoles; Oxazolidinones; Rifampin | 2005 |
In vitro activity of linezolid against Staphylococcus aureus: a population study.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Oxazolidinones; Staphylococcus aureus | 2005 |
Linezolid and rifampin: Drug interaction contrary to expectations?
Topics: Acetamides; Adult; Drug Interactions; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Linezolid; Male; Oxazolidinones; Rifampin; Time Factors | 2005 |
Multiple-dose pharmacokinetics of linezolid during continuous venovenous haemofiltration.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Hemofiltration; Humans; Linezolid; Male; Metabolic Clearance Rate; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Prospective Studies | 2005 |
Efficacy and safety of linezolid in multidrug resistant tuberculosis (MDR-TB)--a report of ten cases.
Topics: Acetamides; Adult; Anemia; Anti-Infective Agents; Bone Marrow Diseases; Drug Therapy, Combination; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Peripheral Nervous System Diseases; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2006 |
Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; In Vitro Techniques; Linezolid; Methicillin; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Structure-Activity Relationship; Vancomycin | 2005 |
Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?
Topics: Acetamides; Acidosis, Lactic; Aged; Anti-Bacterial Agents; Female; Genetic Predisposition to Disease; Humans; Linezolid; Middle Aged; Mitochondria; Oxazolidinones; Polymorphism, Genetic; Protein Biosynthesis | 2005 |
Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Gram-Positive Bacteria; Linezolid; Mice; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 2005 |
Linezolid for the treatment of multidrug-resistant tuberculosis.
Topics: Acetamides; Adult; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2005 |
Penetration of linezolid into soft tissues of healthy volunteers after single and multiple doses.
Topics: Acetamides; Adipose Tissue; Anti-Infective Agents; Area Under Curve; Extracellular Fluid; Humans; Linezolid; Microdialysis; Muscle, Skeletal; Oxazolidinones | 2005 |
In vitro and in vivo activities of DA-7867, a new oxazolidinone, against aerobic gram-positive bacteria.
Topics: Acetamides; Aerobiosis; Animals; Anti-Infective Agents; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxazolidinones | 2005 |
Cost-effectiveness analysis of the treatment of ventilator-associated pneumonia with linezolid or vancomycin in Spain.
Topics: Acetamides; Cost Savings; Cost-Benefit Analysis; Economics, Pharmaceutical; Female; Health Care Costs; Humans; Linezolid; Male; National Health Programs; Oxazolidinones; Pneumonia, Bacterial; Randomized Controlled Trials as Topic; Respiration, Artificial; Retrospective Studies; Spain; Survival Analysis; Treatment Outcome; Vancomycin | 2005 |
[Peripheral and optic neuropathy associated to linezolod in multidrug resistant Mycobacterium bovis infection].
Topics: Acetamides; Aged; Anti-Infective Agents; Humans; Linezolid; Male; Mycobacterium bovis; Optic Nerve Diseases; Oxazolidinones; Peripheral Nervous System Diseases; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2005 |
Comparative in vitro activities of daptomycin, linezolid, and quinupristin/dalfopristin against Gram-positive bacterial isolates from a large cancer center.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Immunocompromised Host; Linezolid; Microbial Sensitivity Tests; Neoplasms; Oxazolidinones; Virginiamycin | 2005 |
Possibly linezolid-induced peripheral and central neurotoxicity: report of four cases.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Brain Diseases; Drug Interactions; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Peripheral Nervous System Diseases; Retrospective Studies | 2005 |
Linezolid contributed to Clostridium difficile colitis with fatal outcome.
Topics: Acetamides; Anti-Infective Agents; Enterocolitis, Pseudomembranous; Fatal Outcome; Humans; Linezolid; Male; Middle Aged; Oxazolidinones | 2005 |
Clinical audit of linezolid use in a large teaching hospital.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacterial Infections; Drug Utilization Review; Hospitals, Teaching; Humans; Linezolid; Oxazolidinones; United Kingdom | 2005 |
Successful medical treatment of multiple brain abscesses due to Nocardia farcinica in a paediatric renal transplant recipient.
Topics: Acetamides; Anti-Infective Agents; Brain Abscess; Child; Humans; Kidney Transplantation; Linezolid; Male; Nocardia Infections; Oxazolidinones | 2005 |
In vitro activity of linezolid against multidrug-resistant Mycobacterium tuberculosis isolates.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones | 2005 |
Linezolid-induced optic neuropathy.
Topics: Acetamides; Adult; Anti-Infective Agents; Female; Humans; Linezolid; Optic Nerve Diseases; Oxazolidinones; Peripheral Nervous System Diseases | 2005 |
Linezolid: low pre-treatment platelet values could increase the risk of thrombocytopenia.
Topics: Acetamides; Anti-Bacterial Agents; Blood Platelets; Female; Humans; Intensive Care Units; Length of Stay; Linezolid; Male; Oxazolidinones; Platelet Count; Prospective Studies; Risk; Thrombocytopenia | 2005 |
Clinical experience with linezolid for the treatment of central nervous system infections.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Brain; Central Nervous System Bacterial Infections; Drug Resistance, Microbial; Female; Humans; Linezolid; Magnetic Resonance Imaging; Male; Middle Aged; Oxazolidinones; Treatment Outcome | 2005 |
[Antibiotic sensitivity of Corynebacterium amycolatum].
Topics: Acetamides; Anti-Bacterial Agents; beta-Lactams; Corynebacterium; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Humans; Lincosamides; Linezolid; Macrolides; Microbial Sensitivity Tests; Mupirocin; Oxazolidinones; Quinolones; Virginiamycin | 2004 |
Trends in linezolid susceptibility patterns: report from the 2002-2003 worldwide Zyvox Annual Appraisal of Potency and Spectrum (ZAAPS) Program.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Global Health; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Product Surveillance, Postmarketing | 2005 |
Pharmacokinetics and intrapulmonary concentrations of linezolid administered to critically ill patients with ventilator-associated pneumonia.
Topics: Acetamides; Anti-Bacterial Agents; Area Under Curve; Bronchoalveolar Lavage Fluid; Cross Infection; Female; Hospitals, University; Humans; Intensive Care Units; Linezolid; Lung; Male; Middle Aged; Oxazolidinones; Pneumonia, Bacterial; Prospective Studies; Respiration, Artificial; Respiratory Mucosa | 2005 |
Is the end-game penetration (of the airway)?
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Humans; Linezolid; Lung; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Pneumonia, Staphylococcal; Respiration, Artificial | 2005 |
Effects of daptomycin, linezolid, and vancomycin on establishment of intestinal colonization with vancomycin-resistant enterococci and extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae in mice.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; beta-Lactamases; Daptomycin; Enterococcus; Female; Humans; Intestines; Klebsiella pneumoniae; Linezolid; Mice; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin; Vancomycin Resistance | 2005 |
Treatment of prosthetic valve infective endocarditis due to multi-resistant Gram-positive bacteria with linezolid.
Topics: Acetamides; Aged; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Electrophoresis, Gel, Pulsed-Field; Endocarditis, Bacterial; Enterococcus faecalis; Female; Gentamicins; Gram-Positive Bacterial Infections; Heart Valve Prosthesis; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus epidermidis; Treatment Outcome; Vancomycin Resistance | 2006 |
Emergence of linezolid-resistant enterococci in a neutropenic patient.
Topics: Acetamides; Adult; Anti-Infective Agents; Bacteremia; Drug Resistance, Bacterial; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Neutropenia; Oxazolidinones | 2006 |
A case of rhombencephalitis caused by Listeria monocytogenes successfully treated with linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Encephalitis; Humans; Linezolid; Listeriosis; Male; Middle Aged; Oxazolidinones | 2006 |
Oxazolidinones inhibit cellular proliferation via inhibition of mitochondrial protein synthesis.
Topics: Acetamides; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Flow Cytometry; Humans; In Vitro Techniques; K562 Cells; Linezolid; Mitochondria, Heart; Oxazoles; Oxazolidinones; Protein Synthesis Inhibitors; Rats; Structure-Activity Relationship | 2005 |
[In vitro activity of linezolid, moxifloxacin, levofloxacin, clindamycin and rifampin, alone and in combination, against Staphylococcus aureus and Staphylococcus epidermidis].
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Clindamycin; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Fluoroquinolones; Levofloxacin; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Ofloxacin; Oxazolidinones; Quinolines; Rifampin; Staphylococcus aureus; Staphylococcus epidermidis | 2005 |
In vitro selection of mutants of Streptococcus pneumoniae resistant to macrolides and linezolid: relationship with susceptibility to penicillin G or macrolides.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Erythromycin; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Penicillin G; RNA, Ribosomal, 23S; Selection, Genetic; Spiramycin; Streptococcus pneumoniae | 2005 |
Varying linezolid susceptibility of vancomycin-resistant Enterococcus faecium isolates during therapy: a case report.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Liver Transplantation; Male; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Time Factors; Vancomycin Resistance; Virginiamycin | 2005 |
Minimal inhibitory concentrations of linezolid against clinical isolates of coryneform bacteria.
Topics: Acetamides; Actinomycetales; Actinomycetales Infections; Anti-Bacterial Agents; Humans; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2005 |
Comparative efficacies of quinupristin-dalfopristin, linezolid, vancomycin, and ciprofloxacin in treatment, using the antibiotic-lock technique, of experimental catheter-related infection due to Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Catheters, Indwelling; Ciprofloxacin; Disease Models, Animal; Drug Therapy, Combination; Linezolid; Male; Oxazolidinones; Plankton; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin; Virginiamycin | 2005 |
In vitro susceptibility of Mycobacterium tuberculosis clinical isolates to garenoxacin and DA-7867.
Topics: Acetamides; Antitubercular Agents; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Fluoroquinolones; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones | 2005 |
Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Cefuroxime; Cephalosporins; Fluoroquinolones; Genetic Variation; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Oxazolidinones; Phenotype; Quinolines; Staphylococcal Infections; Staphylococcus | 2005 |
Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.
Topics: Acetamides; Aged; Anemia, Hemolytic; Bone Marrow; Chloramphenicol; Erythropoiesis; Hemoglobins; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Protein Synthesis Inhibitors; Reticulocyte Count; Reticulocytes; Sepsis; Staphylococcal Infections | 2005 |
Streptococcus suis, Streptococcus mitis, what is the problem?
Topics: Acetamides; Animals; China; Disease Outbreaks; Endocarditis, Bacterial; Hong Kong; Humans; Linezolid; Oxazolidinones; Streptococcal Infections; Streptococcus mitis; Streptococcus suis | 2005 |
A case of Streptococcus mitis endocarditis successfully treated by linezolid.
Topics: Acetamides; Adult; Anti-Infective Agents; Endocarditis, Bacterial; Humans; Linezolid; Male; Oxazolidinones; Streptococcal Infections; Streptococcus mitis | 2005 |
Linezolid in the treatment of severe central nervous system infections resistant to recommended antimicrobial compounds.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Brain Abscess; Brain Neoplasms; Capnocytophaga; Combined Modality Therapy; Craniotomy; Cross Infection; Drainage; Drug Evaluation; Drug Resistance; Epilepsy, Tonic-Clonic; Frontal Lobe; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Mandibular Diseases; Meningitis, Bacterial; Middle Aged; Oligodendroglioma; Osteolysis; Oxazolidinones; Postoperative Complications; Sinusitis | 2005 |
Linezolid-associated serotonin syndrome: what we can learn from cases reported so far.
Topics: Acetamides; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Child, Preschool; Citalopram; Female; Half-Life; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome | 2005 |
Cost-effectiveness of linezolid versus vancomycin in mechanical ventilation-associated nosocomial pneumonia caused by methicillin-resistant staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cost-Benefit Analysis; Cross Infection; Drug Costs; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia, Staphylococcal; Respiration, Artificial; Staphylococcus aureus; Vancomycin | 2005 |
The pharmacokinetics of linezolid in the non-inflamed human eye.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Aqueous Humor; Cataract Extraction; Endophthalmitis; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones | 2005 |
Linezolid use in sepsis due to methicillin-susceptible Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Sepsis; Staphylococcal Infections; Staphylococcus aureus | 2006 |
Improved outcomes with linezolid for methicillin-resistant Staphylococcus aureus infections: better drug or reduced vancomycin susceptibility?
Topics: Acetamides; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Skin Diseases, Bacterial; Soft Tissue Infections; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2005 |
Successful treatment of right-sided prosthetic valve endocarditis due to methicillin-resistant teicoplanin-heteroresistant Staphylococcus aureus with linezolid.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Endocarditis, Bacterial; Heart Valve Prosthesis; Humans; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Prosthesis-Related Infections; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Treatment Outcome; Tricuspid Valve | 2005 |
Successful treatment of MRSA native valve endocarditis with oral linezolid therapy: a case report.
Topics: Acetamides; Administration, Oral; Adult; Anti-Infective Agents; Asthma; Echocardiography; Endocarditis, Bacterial; Female; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2005 |
High-performance liquid chromatographic method for simple and rapid determination of linezolid in human plasma.
Topics: Acetamides; Chromatography, High Pressure Liquid; Drug Stability; Humans; Linezolid; Oxazolidinones; Reproducibility of Results; Sensitivity and Specificity | 2006 |
Linezolid induced toxic optic neuropathy.
Topics: Acetamides; Anti-Bacterial Agents; Drug Administration Schedule; Humans; Linezolid; Male; Middle Aged; Optic Nerve Diseases; Oxazolidinones | 2005 |
In vitro activity of linezolid against key gram-positive organisms isolated in the united states: results of the LEADER 2004 surveillance program.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Product Surveillance, Postmarketing; United States | 2005 |
In vitro synergy of daptomycin plus rifampin against Enterococcus faecium resistant to both linezolid and vancomycin.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Synergism; Drug Therapy, Combination; Enterococcus faecium; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Rifampin; Vancomycin Resistance | 2005 |
Mitochondrial toxicity associated with linezolid.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Asthenia; Brain Abscess; Electron Transport Complex II; Electron Transport Complex IV; Gram-Positive Bacterial Infections; Humans; Lactic Acid; Linezolid; Male; Mitochondria; Mitochondrial Diseases; Oxazolidinones; Prosthesis-Related Infections | 2005 |
Treatment failure of methicillin-resistant Staphylococcus aureus endocarditis with linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Endocarditis, Bacterial; Fatal Outcome; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Mitral Valve; Oxazolidinones; Recurrence; Staphylococcal Infections; Staphylococcus aureus; Treatment Failure; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin | 2005 |
Linezolid diminishes inflammatory cytokine production from human peripheral blood mononuclear cells.
Topics: Acetamides; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythromycin; Humans; Inflammation; Linezolid; Lipopolysaccharides; Monocytes; Oxazolidinones; Protein Biosynthesis; Protein Synthesis Inhibitors | 2006 |
High frequency of linezolid-associated thrombocytopenia and anemia among patients with end-stage renal disease.
Topics: Acetamides; Aged; Aged, 80 and over; Anemia; Anti-Infective Agents; Case-Control Studies; Female; Gram-Positive Bacterial Infections; Humans; Kidney Failure, Chronic; Linezolid; Male; Middle Aged; Oxazolidinones; Renal Dialysis; Retrospective Studies; Thrombocytopenia | 2006 |
Linezolid-resistant E. faecium isolated from an open joint fracture: a report of the first isolate from Italy?
Topics: Accidents, Traffic; Acetamides; Adult; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus faecium; Female; Fractures, Open; Gram-Positive Bacterial Infections; Humans; Italy; Linezolid; Oxazolidinones; Patella | 2005 |
Oxazolidinone susceptibility patterns in 2004: report from the Zyvox Annual Appraisal of Potency and Spectrum (ZAAPS) Program assessing isolates from 16 nations.
Topics: Acetamides; Anti-Infective Agents; Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Population Surveillance | 2006 |
Pharmacoeconomic evaluation of linezolid versus teicoplanin in bacteremia by Gram-positive microorganisms.
Topics: Acetamides; Anti-Infective Agents; Clinical Trials as Topic; Cost-Benefit Analysis; Gram-Positive Bacterial Infections; Hospital Costs; Humans; Linezolid; Models, Economic; Oxazolidinones; Teicoplanin | 2005 |
Urea as an endogenous surrogate in human microdialysis to determine relative recovery of drugs: analytics and applications.
Topics: Acetamides; Adult; Aged; Biomarkers; Calibration; Chemistry, Pharmaceutical; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Linezolid; Male; Microdialysis; Middle Aged; Oxazolidinones; Sensitivity and Specificity; Technology, Pharmaceutical; Time Factors; Urea | 2006 |
An excellent pharmacokinetic profile can actually act as a double-edged sword.
Topics: Acetamides; Critical Care; Critical Illness; Humans; Intensive Care Units; Intestinal Mucosa; Linezolid; Lung; Oxazolidinones; Pneumonia, Bacterial; Prognosis; Respiration, Artificial; Risk Assessment; Severity of Illness Index; Survival Rate; Treatment Outcome | 2006 |
Antibiotic susceptibility of the bacteria causing odontogenic infections.
Topics: Acetamides; Adolescent; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Anaerobic; Clindamycin; Drug Resistance, Bacterial; Female; Focal Infection, Dental; Humans; Linezolid; Male; Metronidazole; Microbial Sensitivity Tests; Middle Aged; Molar, Third; Oxazolidinones; Periapical Periodontitis; Pericoronitis; Tetracycline | 2006 |
The effect of food on plasma and tissue concentrations of linezolid after multiple doses.
Topics: Acetamides; Adipose Tissue; Administration, Oral; Aged; Anti-Bacterial Agents; Extracellular Fluid; Female; Food; Humans; Intestinal Absorption; Linezolid; Male; Microdialysis; Middle Aged; Muscle, Skeletal; Oxazolidinones; Pilot Projects; Tissue Distribution | 2006 |
Hyperlactacidemia potentially due to linezolid overexposure in a liver transplant recipient.
Topics: Acetamides; Anti-Infective Agents; Area Under Curve; Humans; Lactates; Linezolid; Liver Transplantation; Middle Aged; Oxazolidinones | 2006 |
Linezolid and continuous venovenous hemofiltration.
Topics: Acetamides; Anti-Infective Agents; Hemofiltration; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Renal Insufficiency | 2006 |
Determination of the extent of protein binding of antibiotics by means of an automated continuous ultrafiltration method.
Topics: Acetamides; Anti-Bacterial Agents; Automation; Aza Compounds; Fluoroquinolones; Gatifloxacin; Linezolid; Moxifloxacin; Oxazolidinones; Protein Binding; Quinolines; Reproducibility of Results; Serum Albumin, Bovine; Technology, Pharmaceutical; Ultrafiltration | 2006 |
Comment on: linezolid use in sepsis due to methicillin-susceptible Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Sepsis; Staphylococcal Infections; Staphylococcus aureus | 2006 |
In vitro activity of linezolid and other antibiotics against Gram-positive bacteria from the major teaching hospitals in Kuwait.
Topics: Acetamides; Anti-Bacterial Agents; Colony Count, Microbial; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacteria; Hospitals, Teaching; Humans; Kuwait; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Prospective Studies | 2005 |
The effectiveness and safety of oral linezolid for the primary and secondary treatment of osteomyelitis.
Topics: Acetamides; Administration, Oral; Aged; Aged, 80 and over; Anti-Infective Agents; Hospitals, Veterans; Humans; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones; Retrospective Studies | 2005 |
Linezolid in prophylaxis against experimental aortic valve endocarditis due to Streptococcus oralis or Enterococcus faecalis.
Topics: Acetamides; Animals; Aortic Valve; Endocarditis, Bacterial; Enterococcus faecalis; Female; Gram-Positive Bacterial Infections; Heart Valve Diseases; Linezolid; Oxazolidinones; Rabbits; Streptococcal Infections | 2006 |
Successful treatment of staphylococcal toxic shock syndrome with linezolid: a case report and in vitro evaluation of the production of toxic shock syndrome toxin type 1 in the presence of antibiotics.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Toxins; Enterotoxins; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Shock, Septic; Staphylococcal Infections; Staphylococcus aureus; Superantigens | 2006 |
Measurement of ampicillin, vancomycin, linezolid and gentamicin activity against enterococcal biofilms.
Topics: Acetamides; Ampicillin; Anti-Bacterial Agents; Bacteremia; Biofilms; Catheterization, Central Venous; Enterococcus faecalis; Enterococcus faecium; Gentamicins; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin | 2006 |
Drug interactions between linezolid and selective serotonin reuptake inhibitors: case report involving sertraline and review of the literature.
Topics: Acetamides; Amputation Stumps; Anti-Bacterial Agents; Depressive Disorder; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Interactions; Fatal Outcome; Female; Gangrene; Humans; Linezolid; Middle Aged; Neurotoxicity Syndromes; Oxazolidinones; Selective Serotonin Reuptake Inhibitors; Sertraline; Surgical Wound Infection | 2006 |
Comparative study of antimicrobial release kinetics from polymethylmethacrylate.
Topics: Acetamides; Anti-Bacterial Agents; Area Under Curve; Cefazolin; Ciprofloxacin; Fluoroquinolones; Gatifloxacin; Humans; Levofloxacin; Linezolid; Ofloxacin; Oxazolidinones; Polymethyl Methacrylate; Rifampin | 2006 |
Successful treatment with linezolid and rifampicin of meningitis due to methicillin-resistant Staphylococcus epidermidis refractory to vancomycin treatment.
Topics: Acetamides; Anti-Bacterial Agents; Drug Therapy, Combination; Female; Humans; Linezolid; Meningitis, Bacterial; Methicillin Resistance; Middle Aged; Oxazolidinones; Rifampin; Staphylococcal Infections; Staphylococcus epidermidis; Treatment Outcome; Vancomycin | 2006 |
Linezolid treatment of glycopeptide-resistant Enterococcus faecium in very low birth weight premature neonates.
Topics: Acetamides; Drug Resistance, Bacterial; Enterococcus faecium; Female; Glycopeptides; Gram-Positive Bacterial Infections; Humans; Infant, Newborn; Infant, Very Low Birth Weight; Linezolid; Male; Oxazolidinones; Premature Birth; Safety | 2006 |
Exacerbation of chronic epidural abscess following a fludarabine-based preparative regimen.
Topics: Acetamides; Anemia, Aplastic; Anti-Infective Agents; Epidural Abscess; Graft vs Host Disease; Humans; Linezolid; Male; Middle Aged; Myeloablative Agonists; Oxazolidinones; Radiography; Staphylococcal Infections; Stem Cell Transplantation; Vidarabine | 2006 |
Catheter lock and systemic infusion of linezolid for treatment of persistent Broviac catheter-related staphylococcal bacteremia.
Topics: Acetamides; Anti-Infective Agents; Bacteremia; Catheterization, Central Venous; Child, Preschool; Female; Follow-Up Studies; Humans; Linezolid; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Time Factors; Treatment Outcome | 2006 |
Emergence of linezolid resistance in Enterococcus faecium not dependent on linezolid treatment.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus faecium; Fatal Outcome; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Vancomycin Resistance | 2006 |
Linezolid in the treatment of brain abscess due to Peptostreptococcus.
Topics: Acetamides; Adult; Anti-Infective Agents; Brain Abscess; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Oxazolidinones; Peptostreptococcus; Thalamus; Treatment Outcome | 2006 |
Does haemodialysis significantly affect serum linezolid concentrations in critically ill patients with renal failure? A pilot investigation.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; APACHE; Critical Care; Critical Illness; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Humans; Infusions, Intravenous; Kidney Failure, Chronic; Kidney Function Tests; Linezolid; Male; Oxazolidinones; Pilot Projects; Renal Dialysis; Risk Assessment; Sampling Studies; Sensitivity and Specificity; Survival Rate; Treatment Outcome | 2006 |
Linezolid-associated toxic optic neuropathy.
Topics: Acetamides; Adult; Anti-Infective Agents; Color Perception; Female; Humans; Linezolid; Methicillin Resistance; Optic Nerve Diseases; Oxazolidinones; Staphylococcal Infections | 2006 |
[Successful salvage of a patient with cardiac arrest caused by multiple pulmonary emboli and lung abscesses due to infective endocarditis of the tricuspid valve: a case report].
Topics: Acetamides; Adult; Anti-Infective Agents; Endocarditis, Bacterial; Extracorporeal Circulation; Female; Heart Arrest; Heart Valve Prosthesis; Humans; Linezolid; Lung Abscess; Methicillin Resistance; Oxazolidinones; Pulmonary Embolism; Salvage Therapy; Staphylococcal Infections; Tricuspid Valve | 2006 |
Comparison of testing methods for detection of decreased linezolid susceptibility due to G2576T mutation of the 23S rRNA gene in Enterococcus faecium and Enterococcus faecalis.
Topics: Acetamides; Anti-Bacterial Agents; Bacteriological Techniques; Base Sequence; DNA, Bacterial; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Genes, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Point Mutation; Polymerase Chain Reaction; RNA, Bacterial; RNA, Ribosomal, 23S | 2006 |
Emergence of linezolid resistance in the vancomycin-resistant Enterococcus faecium multilocus sequence typing C1 epidemic lineage.
Topics: Acetamides; Alleles; Base Sequence; Cross Infection; Disease Outbreaks; DNA, Bacterial; Drug Resistance, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Italy; Linezolid; Molecular Epidemiology; Oxazolidinones; RNA, Bacterial; RNA, Ribosomal, 23S; Vancomycin Resistance | 2006 |
Combined treatment with ceftriaxone and linezolid of pneumococcal meningitis: a case series including penicillin-resistant strains.
Topics: Acetamides; Adult; Aged; Ceftriaxone; Drug Therapy, Combination; Female; Humans; Linezolid; Male; Meningitis, Pneumococcal; Middle Aged; Oxazolidinones; Penicillin Resistance; Penicillins; Streptococcus pneumoniae; Treatment Outcome | 2006 |
Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis.
Topics: Acetamides; Anti-Bacterial Agents; Brazil; Child; Cystic Fibrosis; Drug Resistance, Bacterial; Female; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus | 2006 |
Linezolid audit: similarities and contrasts with published experience.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Infections; Drug Utilization Review; Hospital Bed Capacity, 500 and over; Hospitals, Teaching; Humans; Linezolid; Oxazolidinones; Scotland | 2006 |
Intravenous linezolid administered orally: a novel desensitization strategy.
Topics: Acetamides; Administration, Oral; Adult; Anti-Infective Agents; Desensitization, Immunologic; Drug Resistance, Microbial; Enterococcus; Enterococcus faecium; Female; Humans; Linezolid; Myasthenia Gravis; Oxazolidinones | 2006 |
Impact of Enterococcus faecalis on the bactericidal activities of arbekacin, daptomycin, linezolid, and tigecycline against methicillin-resistant Staphylococcus aureus in a mixed-pathogen pharmacodynamic model.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Daptomycin; Dibekacin; Enterococcus faecalis; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Staphylococcus aureus; Tigecycline | 2006 |
Bactericidal activities of R207910 and other newer antimicrobial agents against Mycobacterium leprae in mice.
Topics: Acetamides; Animals; Anti-Infective Agents; Aza Compounds; Diarylquinolines; Female; Fluoroquinolones; Leprosy; Linezolid; Mice; Moxifloxacin; Mycobacterium leprae; Nitroimidazoles; Oxazolidinones; Quinolines | 2006 |
Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Gram-Positive Bacterial Infections; Humans; Linezolid; Middle Aged; Oxazolidinones; Retrospective Studies | 2006 |
Linezolid-induced inhibition of mitochondrial protein synthesis.
Topics: Acetamides; Animals; Anti-Infective Agents; DNA, Mitochondrial; Drug Therapy, Combination; Female; Humans; Kidney; Linezolid; Male; Middle Aged; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Oxazolidinones; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Rifampin; Staphylococcal Infections | 2006 |
Linezolid and human polymorphonuclear leukocyte function.
Topics: Acetamides; Anti-Bacterial Agents; Chemotaxis, Leukocyte; Flow Cytometry; Humans; Linezolid; Neutrophils; Oxazolidinones; Phagocytosis; Respiratory Burst | 2006 |
Thrombocytopenia and anemia associated with linezolid in patients with kidney failure.
Topics: Acetamides; Anemia; Anti-Infective Agents; Humans; Kidney Failure, Chronic; Linezolid; Oxazolidinones; Platelet Count; Retrospective Studies; Thrombocytopenia | 2006 |
Early experience with linezolid for infections in orthopaedics.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Orthopedic Procedures; Oxazolidinones; Prosthesis-Related Infections; Recurrence; Reoperation; Surgical Wound Infection; Treatment Outcome | 2006 |
In vitro activities of DX-619 and four comparator agents against 376 anaerobic bacterial isolates.
Topics: Acetamides; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Aza Compounds; Bacteria, Anaerobic; Fluoroquinolones; Humans; In Vitro Techniques; Inhibitory Concentration 50; Linezolid; Meropenem; Microbial Sensitivity Tests; Molecular Structure; Moxifloxacin; Oxazolidinones; Pyrrolidines; Quinolines; Quinolones; Thienamycins | 2006 |
Is linezolid superior to vancomycin for complicated skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus?
Topics: Acetamides; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Soft Tissue Infections; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin | 2006 |
Multi-systemic methicillin resistant Staphylococcus aureus (MRSA) community-acquired infection.
Topics: Acetamides; Anti-Bacterial Agents; Clindamycin; Community-Acquired Infections; Humans; Linezolid; Low Back Pain; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Spinal Diseases; Staphylococcus aureus | 2006 |
[Is your patient MRSA (multi-resistent Staphylococcus aureus) free?].
Topics: Acetamides; Anti-Bacterial Agents; Carrier State; Cross Infection; Drug Resistance, Multiple; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Patient Admission; Preoperative Care; Staphylococcal Skin Infections; Staphylococcus aureus | 2006 |
State of the knowledge of bacterial resistance.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Bacterial; Glycopeptides; Humans; Ketolides; Linezolid; Methicillin; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2006 |
Central venous catheter colonization by linezolid-resistant, vancomycin-susceptible Enterococcus faecalis.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacteremia; Catheterization, Central Venous; Drug Resistance, Bacterial; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Oxazolidinones; Vancomycin | 2006 |
What can we learn from studies comparing linezolid with vancomycin in neutropenic patients when vancomycin dosages are not optimized?
Topics: Acetamides; Anti-Bacterial Agents; Fever; Humans; Linezolid; Neutropenia; Oxazolidinones; Vancomycin | 2006 |
Effectiveness of linezolid and imipenem association in the treatment of severe community-acquired pneumonia in children: two case reports.
Topics: Acetamides; Anti-Bacterial Agents; Child, Preschool; Community-Acquired Infections; Drug Synergism; Drug Therapy, Combination; Female; Humans; Imipenem; Linezolid; Male; Oxazolidinones; Pneumonia, Bacterial; Safety; Treatment Outcome | 2006 |
First report of a linezolid- and vancomycin-resistant Enterococcus faecium strain in Korea.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Base Sequence; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Korea; Linezolid; Male; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Polymorphism, Restriction Fragment Length; Treatment Outcome; Vancomycin Resistance | 2006 |
Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetamides; Adamantane; Aminobenzoates; Aminoglycosides; Anilides; Animals; Anti-Bacterial Agents; Apoproteins; Bacterial Proteins; Crystallography, X-Ray; Linezolid; Lipids; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Oxazolidinones; Streptomyces; Substrate Specificity | 2006 |
In vitro and in vivo activities of rifampin, streptomycin, amikacin, moxifloxacin, R207910, linezolid, and PA-824 against Mycobacterium ulcerans.
Topics: Acetamides; Amikacin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Colony Count, Microbial; Diarylquinolines; Dose-Response Relationship, Drug; Female; Fluoroquinolones; Foot; In Vitro Techniques; Linezolid; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Moxifloxacin; Mycobacterium Infections, Nontuberculous; Mycobacterium ulcerans; Nitroimidazoles; Oxazolidinones; Quinolines; Rifampin; Streptomycin; Survival Analysis; Time Factors | 2006 |
Clearance of linezolid via continuous venovenous hemodiafiltration.
Topics: Acetamides; Acute Kidney Injury; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Bacterial; Fasciitis, Necrotizing; Hemofiltration; Humans; Linezolid; Male; Metabolic Clearance Rate; Oxazolidinones; Time Factors; Urinary Tract Infections; Vancomycin | 2006 |
Linezolid-resistant Staphylococcus aureus in two pediatric patients receiving low-dose linezolid therapy.
Topics: Acetamides; Adolescent; Child; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Bacterial; Female; Follow-Up Studies; Humans; Immunocompromised Host; Job Syndrome; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Risk Assessment; Siblings; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2006 |
In vitro susceptibility of Gram-positive pathogens to linezolid and teicoplanin and effect on outcome in critically ill patients.
Topics: Acetamides; Anti-Bacterial Agents; Critical Illness; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Inpatients; Intensive Care Units; Length of Stay; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Teicoplanin; Treatment Outcome | 2006 |
In vitro activity of linezolid against Mycobacterium tuberculosis complex, including multidrug-resistant Mycobacterium bovis isolates.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Microbial; Linezolid; Microbial Sensitivity Tests; Mycobacterium bovis; Mycobacterium tuberculosis; Oxazolidinones | 2006 |
Epidemiological profile of linezolid-resistant coagulase-negative staphylococci.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Risk Factors; Staphylococcal Infections; Staphylococcus epidermidis | 2006 |
Linezolid and serotonergic drug interactions: a retrospective survey.
Topics: Acetamides; Adult; Aged, 80 and over; Anti-Infective Agents; Cyclohexanols; Drug Interactions; Female; Humans; Incidence; Linezolid; Monoamine Oxidase Inhibitors; Oxazolidinones; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Venlafaxine Hydrochloride | 2006 |
Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Chemistry, Pharmaceutical; Drug Design; Drug Resistance, Bacterial; Drug Resistance, Microbial; Fluorine; Linezolid; Microbial Sensitivity Tests; Models, Chemical; Molecular Conformation; Oxazoles; Oxazolidinones; Structure-Activity Relationship | 2006 |
Pharmacokinetics of unbound linezolid in plasma and tissue interstitium of critically ill patients after multiple dosing using microdialysis.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Critical Illness; Extracellular Space; Humans; Linezolid; Microdialysis; Muscle, Skeletal; Oxazolidinones; Sepsis; Shock, Septic; Subcutaneous Fat; Tissue Distribution | 2006 |
In vitro and in vivo assessment of linezolid combined with ertapenem: a highly synergistic combination against methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Infective Agents; beta-Lactams; Drug Synergism; Endocarditis, Bacterial; Ertapenem; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Rabbits; Staphylococcal Infections; Staphylococcus aureus | 2006 |
Persistent Staphylococcus capitis septicemia in a preterm infant.
Topics: Acetamides; Anti-Infective Agents; Gastrointestinal Tract; Humans; Infant, Newborn; Linezolid; Male; Oxazolidinones; Rifampin; Sepsis; Staphylococcal Infections; Staphylococcus | 2006 |
A holistic approach to MRSA eradication in critically ill patients with MRSA pneumonia.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Critical Illness; Cross Infection; Drug Utilization; Female; Humans; Infection Control; Intensive Care Units; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin | 2006 |
Short course of linezolid treatment for vancomycin-resistant Enterococcus faecium meningitis.
Topics: Acetamides; Aged; Anti-Infective Agents; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Meningitis, Bacterial; Oxazolidinones; Vancomycin Resistance | 2006 |
Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus; Linezolid; Molecular Structure; Oxazolidinones; Pyridines; Staphylococcus aureus; Structure-Activity Relationship | 2006 |
[Synthesis and antibacterial activity of (S) -5-acetylaminomethyl-3-[(4-substituted-aminomethyl) phenyl] -2-oxazolindinone derivatives].
Topics: Acetamides; Anti-Bacterial Agents; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Staphylococcus; Streptococcus | 2006 |
Linezolid resistance in coagulase-negative staphylococci.
Topics: Acetamides; Anti-Infective Agents; Coagulase; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Staphylococcus epidermidis | 2006 |
Novel bacterial acetyl coenzyme A carboxylase inhibitors with antibiotic efficacy in vivo.
Topics: Acetamides; Acetyl-CoA Carboxylase; Amides; Amino Acid Sequence; Amino Acid Substitution; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Colony Count, Microbial; Disease Models, Animal; Enzyme Inhibitors; Female; Gram-Positive Bacteria; Humans; In Vitro Techniques; Linezolid; Male; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Molecular Sequence Data; Oxazolidinones; Rats; Rats, Wistar; Sepsis; Solubility; Staphylococcus aureus; Structure-Activity Relationship; Survival Analysis; Water | 2006 |
Treatment of community-acquired methicillin-resistant Staphylococcus aureus infection.
Topics: Acetamides; Anti-Infective Agents; Community-Acquired Infections; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Soft Tissue Infections; Staphylococcal Infections; Staphylococcal Skin Infections; Staphylococcus aureus | 2006 |
Enhanced activity of rifalazil in combination with levofloxacin, linezolid, or mupirocin against Staphylococcus aureus in vitro.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Drug Therapy, Combination; Levofloxacin; Linezolid; Microbial Sensitivity Tests; Mupirocin; Ofloxacin; Oxazolidinones; Rifamycins; Staphylococcus aureus | 2006 |
Nosocomial spondylodiskitis with epidural abscess and CSF fistula cured with quinupristin/dalfopristin and linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Cerebrospinal Fluid; Combined Modality Therapy; Cross Infection; Curettage; Device Removal; Discitis; Epidural Abscess; Female; Fistula; Fluconazole; Fungi; Humans; Internal Fixators; Laminectomy; Linezolid; Lumbar Vertebrae; Meropenem; Methicillin Resistance; Middle Aged; Osteomyelitis; Oxazolidinones; Parkinson Disease; Prosthesis-Related Infections; Reoperation; Skin Diseases; Spinal Diseases; Spinal Stenosis; Staphylococcal Infections; Thienamycins; Virginiamycin | 2006 |
Ranbezolid, a novel oxazolidinone antibacterial: in vivo characterisation of monoamine oxidase inhibitory potential in conscious rats.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Blood Pressure; Clorgyline; Dose-Response Relationship, Drug; Furans; Linezolid; Male; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Rats; Rats, Wistar | 2006 |
In vitro activity of linezolid against clinical isolates of Fusobacterium spp.
Topics: Acetamides; Anaerobiosis; Anti-Infective Agents; Drug Resistance, Bacterial; Fusobacterium; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Species Specificity | 2006 |
Impact of selective antimicrobial agents on staphylococcal adherence to biomedical devices.
Topics: Acetamides; Anti-Bacterial Agents; Biofilms; Blood Vessel Prosthesis; Ceftriaxone; Daptomycin; Gentamicins; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Rifampin; Staphylococcus; Vancomycin | 2006 |
Resistance to macrolides, lincosamides, streptogramins, and linezolid among members of the Staphylococcus sciuri group.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Colony Count, Microbial; Drug Resistance, Multiple, Bacterial; Lincosamides; Linezolid; Macrolides; Microbial Sensitivity Tests; Oxazolidinones; Polymerase Chain Reaction; Staphylococcus; Streptogramins | 2006 |
Severe invasive beta haemolytic group A streptococcal cellulitis and eyelid necrosis treated with linezolid.
Topics: Acetamides; Aged; Aged, 80 and over; Cellulitis; Eye Infections, Bacterial; Eyelid Diseases; Eyelids; Humans; Linezolid; Male; Necrosis; Oxazolidinones; Streptococcal Infections; Streptococcus pyogenes | 2006 |
The clinical impact of linezolid susceptibility reporting in patients with vancomycin-resistant enterococci.
Topics: Academic Medical Centers; Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Cohort Studies; Cross Infection; Disease Susceptibility; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Length of Stay; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Retrospective Studies; Treatment Outcome; Vancomycin; Vancomycin Resistance | 2006 |
High frequency of linezolid-associated thrombocytopenia among patients with renal insufficiency.
Topics: Acetamides; Adult; Anemia; Anti-Infective Agents; Case-Control Studies; Female; Humans; Kidney Failure, Chronic; Linezolid; Male; Middle Aged; Oxazolidinones; Renal Dialysis; Retrospective Studies; Safety; Thrombocytopenia | 2006 |
Nosocomial spread of Enterococcus faecium resistant to vancomycin and linezolid in a tertiary care medical center.
Topics: Academic Medical Centers; Acetamides; Adult; Aged; Aged, 80 and over; Alabama; Anti-Infective Agents; Cross Infection; Disease Outbreaks; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Vancomycin; Vancomycin Resistance | 2006 |
Possible macular exanthema associated with linezolid therapy.
Topics: Acetamides; Anti-Infective Agents; Exanthema; Humans; Linezolid; Male; Middle Aged; Oxazolidinones | 2006 |
Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation.
Topics: Acetamides; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chromatography, High Pressure Liquid; Citrobacter freundii; Coloring Agents; Enterobacter aerogenes; Escherichia coli; Ethidium; Fluorometry; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Pyronine | 2007 |
Effectiveness and tolerability of prolonged linezolid treatment for chronic osteomyelitis: a retrospective study.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anemia; Anti-Infective Agents; Chronic Disease; Female; Humans; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones; Retrospective Studies | 2006 |
Cost-effectiveness analysis of linezolid compared with vancomycin for the treatment of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Cost-Benefit Analysis; Cross Infection; Female; Health Care Costs; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Randomized Controlled Trials as Topic; Staphylococcus aureus; Vancomycin | 2006 |
Rapid emergence of resistance to linezolid during linezolid therapy of an Enterococcus faecium infection.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Time Factors; Treatment Outcome | 2006 |
Complete blindness after optic neuropathy induced by short-term linezolid treatment in a patient suffering from muscle dystrophy.
Topics: Acetamides; Adult; Anti-Infective Agents; Blindness; Bronchopneumonia; Drug Administration Schedule; Female; Humans; Linezolid; Muscular Dystrophies; Optic Nerve Diseases; Oxazolidinones | 2007 |
First report of Listeria monocytogenes endocarditis treated with linezolid.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Diagnosis, Differential; Endocarditis, Bacterial; Humans; Linezolid; Listeria monocytogenes; Listeriosis; Male; Oxazolidinones; RNA, Ribosomal, 16S; Treatment Outcome | 2006 |
Urinary bactericidal activity of oral antibiotics against common urinary tract pathogens in an ex vivo model.
Topics: Acetamides; Administration, Oral; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; beta-Lactamases; Biomarkers; Cefadroxil; Ceftibuten; Cefuroxime; Cephalexin; Cephalosporins; Ciprofloxacin; Disk Diffusion Antimicrobial Tests; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Middle Aged; Norfloxacin; Oxazolidinones; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Tract Infections | 2006 |
Efficacy of high doses of levofloxacin in experimental foreign-body infection by methicillin-susceptible Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cloxacillin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Foreign-Body Reaction; Humans; Levofloxacin; Linezolid; Male; Methicillin; Microbial Sensitivity Tests; Ofloxacin; Oxazolidinones; Rats; Rats, Wistar; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2006 |
First isolation of Clostridium amygdalinum from a patient with chronic osteitis.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Chronic Disease; Clostridium; Clostridium Infections; Humans; Linezolid; Male; Molecular Sequence Data; Osteitis; Oxazolidinones; Phylogeny | 2006 |
Disseminated nontuberculous mycobacterial infections in sickle cell anemia patients.
Topics: Acetamides; Adolescent; Amikacin; Anemia, Sickle Cell; Anti-Bacterial Agents; Cefoxitin; Ciprofloxacin; Clarithromycin; Doxycycline; Drug Therapy, Combination; Female; Humans; Hydroxyurea; Linezolid; Microbial Sensitivity Tests; Mycobacterium fortuitum; Mycobacterium Infections; Oxazolidinones; Treatment Outcome | 2006 |
Treatment of post-traumatic hand Staphylococcus aureus osteomyelitis with oral linezolid.
Topics: Acetamides; Administration, Oral; Aged; Anti-Infective Agents; Biological Availability; Chronic Disease; Diabetes Complications; Finger Injuries; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Osteomyelitis; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2006 |
Linezolid as rescue drug: a clinical case of soft tissue infection caused by a Staphylococcus aureus strain resistant in vivo to teicoplanin.
Topics: Acetamides; Aged; Airway Obstruction; Anti-Infective Agents; Cellulitis; Diagnosis, Differential; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Male; Oxazolidinones; Salvage Therapy; Soft Tissue Infections; Staphylococcal Infections; Teicoplanin | 2006 |
Linezolid-resistant Enterococcus faecalis: first report in Spain.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Middle Aged; Oxazolidinones; Spain | 2006 |
Linezolid therapy of bloodborne teicoplanin-resistant Staphylococcus haemolyticus.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Drug Resistance, Bacterial; Female; Humans; Linezolid; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus haemolyticus; Teicoplanin | 2006 |
Activity of DX-619 compared to other agents against viridans group streptococci, Streptococcus bovis, and Cardiobacterium hominis.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; beta-Lactams; Cardiobacterium; Drug Resistance, Bacterial; Glycolipids; Ketolides; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Pyrrolidines; Quinolones; Streptococcus bovis; Viridans Streptococci | 2006 |
Efficacy of linezolid versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus discitis: a controlled animal model.
Topics: Acetamides; Animals; Discitis; Disease Models, Animal; Linezolid; Methicillin Resistance; Oxazolidinones; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2006 |
Linezolid and serotonergic drug interactions.
Topics: Acetamides; Anti-Infective Agents; Drug Interactions; Humans; Linezolid; Oxazolidinones; Serotonin; Serotonin Syndrome | 2006 |
Successful salvage therapy with tigecycline after linezolid failure in a liver transplant recipient with MRSA pneumonia.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Humans; Linezolid; Liver Transplantation; Male; Methicillin Resistance; Middle Aged; Minocycline; Oxazolidinones; Pneumonia, Staphylococcal; Salvage Therapy; Staphylococcus aureus; Tigecycline; Treatment Failure; Treatment Outcome | 2006 |
Tongue discoloration in an elderly kidney transplant recipient: Treatment-related adverse event?
Topics: Acetamides; Aged; Anti-Infective Agents; Humans; Immunocompromised Host; Kidney Transplantation; Linezolid; Male; Oxazolidinones; Tongue Diseases; Urinary Tract Infections | 2006 |
Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF).
Topics: Acetamides; Alleles; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B; DNA, Bacterial; DNA, Complementary; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Proteins; Levofloxacin; Linezolid; Membrane Transport Proteins; Microbial Sensitivity Tests; Models, Molecular; Ofloxacin; Oxazolidinones; Phenotype; Phenylalanine; Point Mutation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Bacterial | 2007 |
High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
Topics: Acetamides; Aminoglycosides; Biofilms; Catheters, Indwelling; Chloramphenicol; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; Female; Fluoroquinolones; Humans; Linezolid; Macrolides; Microbial Sensitivity Tests; Micrococcus; Middle Aged; Morganella morganii; Oxazolidinones; Penicillins; Pseudomonas aeruginosa; Rifampin; Staphylococcus aureus; Tetracyclines; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Catheterization; Vancomycin; Vancomycin Resistance | 2007 |
Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Antimycin A; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Chloramphenicol; Clindamycin; Dose-Response Relationship, Drug; Fluoroquinolones; Glycolysis; HeLa Cells; Humans; Lactic Acid; Linezolid; Macrolides; Mitochondria; Osteoblasts; Oxazolidinones; Rotenone; Tetracyclines; Time Factors | 2007 |
Interscience conference on antimicrobial agents and chemotherapy--46th annual meeting. New oxazolidinone antibiotics by Wockhardt and Kyorin. 27-30 September 2006, San Francisco, CA, USA.
Topics: Acetamides; Animals; Anti-Infective Agents; Drug Design; Drugs, Investigational; Humans; Linezolid; Oxazolidinones; Societies, Scientific; United States | 2006 |
In vitro activity of linezolid in combination with doxycycline, fosfomycin, levofloxacin, rifampicin and vancomycin against methicillin-susceptible Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Doxycycline; Drug Therapy, Combination; Enzyme Inhibitors; Fosfomycin; Humans; In Vitro Techniques; Levofloxacin; Linezolid; Microbial Sensitivity Tests; Ofloxacin; Oxazolidinones; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2006 |
In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Staphylococcus; Streptococcus | 2007 |
Comment: impact of linezolid on economic outcomes and determinants of cost in a clinical trial evaluating patients with MRSA complicated skin and soft-tissue infections.
Topics: Acetamides; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Soft Tissue Infections; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2006 |
Serotonin syndrome precipitated by linezolid in a medically ill patient on duloxetine.
Topics: Acetamides; Anti-Infective Agents; Antidepressive Agents; Depression; Drug Interactions; Duloxetine Hydrochloride; Female; Humans; Linezolid; Middle Aged; Monoamine Oxidase Inhibitors; Oxazolidinones; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Surgical Wound Dehiscence; Thiophenes | 2006 |
What is the place of teicoplanin and linezolid in the treatment of prosthetic joint infections?
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Joint Diseases; Joint Prosthesis; Linezolid; Oxazolidinones; Prosthesis-Related Infections; Teicoplanin | 2006 |
EUCAST Technical Note on linezolid.
Topics: Acetamides; Administration, Oral; Anti-Infective Agents; Enterococcus; Europe; Gram-Positive Bacterial Infections; Humans; Infusion Pumps; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus | 2006 |
A puzzling microbiological and clinical discrepancy in the management of acute, severe skin-soft tissue and joint staphylococcal infection. In vitro antimicrobial susceptibility to glycopeptides, versus in vivo clinical efficacy of linezolid alone.
Topics: Acetamides; Acute Disease; Anti-Infective Agents; Glycopeptides; Humans; Joint Diseases; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Severity of Illness Index; Soft Tissue Infections; Staphylococcal Infections | 2006 |
Visual side effects after prolonged MRSA treatment.
Topics: Acetamides; Aged; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Evoked Potentials, Visual; Humans; Linezolid; Male; Oxazolidinones; Staphylococcal Infections; Vision Disorders; Vision Tests; Visual Acuity | 2007 |
Listeria monocytogenes meningitis and multiple brain abscesses in an immunocompetent host. Favorable response to combination linezolid-meropenem treatment.
Topics: Acetamides; Anemia; Anti-Bacterial Agents; Brain Abscess; Drug Therapy, Combination; Humans; Immunocompetence; Linezolid; Male; Meningitis, Listeria; Meropenem; Middle Aged; Oxazolidinones; Thienamycins | 2006 |
[Linezolid in the treatment of antibiotic-resistant gram-positive infections of the musculoskeletal system].
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthroplasty; Drug Resistance, Bacterial; Female; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Muscular Diseases; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis | 2006 |
A case of Enterococcus faecalis prosthetic joint infection: a rare and difficult infection to treat.
Topics: Acetamides; Anti-Infective Agents; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Knee Prosthesis; Linezolid; Male; Middle Aged; Oxazolidinones; Prosthesis-Related Infections | 2006 |
In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Biofilms; DNA, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Nafcillin; Oxazolidinones; Penicillin-Binding Proteins; Penicillins; Reverse Transcriptase Polymerase Chain Reaction; Staphylococcal Infections; Staphylococcus; Tetracycline | 2007 |
Staphylococcus aureus biofilm as a target for single or repeated doses of oxacillin, vancomycin, linezolid and/or lysostaphin.
Topics: Acetamides; Anti-Bacterial Agents; Biofilms; Drug Therapy, Combination; Humans; Linezolid; Lysostaphin; Microbial Sensitivity Tests; Microscopy, Confocal; Oxacillin; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2006 |
Reactivation of dormant lumbar methicillin-resistant Staphylococcus aureus osteomyelitis after 12 years.
Topics: Abscess; Acetamides; Adult; Anti-Bacterial Agents; Bacteremia; Debridement; Drug Therapy, Combination; Humans; Intervertebral Disc Displacement; Laminectomy; Linezolid; Lumbar Vertebrae; Male; Methicillin Resistance; Osteomyelitis; Oxazolidinones; Recurrence; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Time Factors; Treatment Outcome; Vancomycin | 2007 |
Mild serotonin syndrome associated with concurrent linezolid and fluoxetine.
Topics: Acetamides; Adult; Anti-Infective Agents; Drug Interactions; Drug Therapy, Combination; Humans; Leukemia, Myeloid, Acute; Linezolid; Male; Oxazolidinones; Pyrimidines; Serotonin Syndrome; United States | 2007 |
Impact of antibiotics on expression of virulence-associated exotoxin genes in methicillin-sensitive and methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Toxins; Clindamycin; Enterotoxins; Exotoxins; Hemolysin Proteins; Leukocidins; Linezolid; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Nafcillin; Oxazolidinones; Protein Synthesis Inhibitors; Rabbits; Staphylococcus aureus; Superantigens; Vancomycin; Virulence | 2007 |
Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; DNA; Electron Transport; Electron Transport Complex IV; Female; Humans; Lactates; Linezolid; Longitudinal Studies; Male; Membrane Potentials; Mitochondria; Oxazolidinones; Oxidation-Reduction; Protein Synthesis Inhibitors; RNA | 2007 |
In vitro efficacy of Linezolid on clinical strains of Mycobacterium tuberculosis and other mycobacteria.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Italy; Linezolid; Microbial Sensitivity Tests; Mycobacterium; Mycobacterium tuberculosis; Oxazolidinones | 2006 |
Bactericidal activity of daptomycin, vancomycin, teicoplanin and linezolid against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium using human peak free serum drug concentrations.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Teicoplanin; Vancomycin | 2007 |
Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Population Surveillance | 2007 |
In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Polymorphism, Restriction Fragment Length; Reverse Transcriptase Polymerase Chain Reaction; Staphylococcus aureus | 2007 |
Pacemaker infections due to rapidly growing mycobacteria: further experience.
Topics: Acetamides; Aged; Anti-Infective Agents; Clarithromycin; Drug Therapy, Combination; Female; Humans; Linezolid; Mycobacterium Infections; Ofloxacin; Oxazolidinones; Pacemaker, Artificial; Prosthesis-Related Infections; Surgical Wound Infection | 2007 |
In vitro activities of tigecycline, daptomycin, linezolid and quinupristin/dalfopristin against glycopeptide-resistant Enterococcus faecium.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Daptomycin; Drug Resistance, Bacterial; Enterococcus faecium; Glycopeptides; Gram-Positive Bacterial Infections; Humans; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Tigecycline; Virginiamycin | 2007 |
Linezolid-based therapy in Staphylococcus epidermidis endocarditis.
Topics: Acetamides; Aged; Anti-Infective Agents; Cross Infection; Endocarditis, Bacterial; Humans; Linezolid; Male; Oxazolidinones; Staphylococcus epidermidis | 2007 |
Oxazolidinone susceptibility patterns for 2005: International Report from the Zyvox Annual Appraisal of Potency and Spectrum Study.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterococcus; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Streptococcus; Streptococcus pneumoniae | 2007 |
First linezolid-resistant clinical isolates of Mycobacterium tuberculosis.
Topics: Acetamides; Antitubercular Agents; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2007 |
Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model.
Topics: Acetamides; Area Under Curve; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Models, Biological; Oxazolidinones | 2007 |
[Use of linezolid for the treatment of lung infections in adults with cystic fibrosis].
Topics: Acetamides; Adult; Anti-Infective Agents; Cystic Fibrosis; Female; Humans; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Pneumonia, Staphylococcal; Practice Guidelines as Topic; Protein Synthesis Inhibitors; Retrospective Studies; Staphylococcus aureus; Treatment Outcome | 2006 |
Hospital-acquired vancomycin-resistant enterococci: now appearing in Kuala Lumpur Hospital.
Topics: Acetamides; Adult; Anti-Infective Agents; Cross Infection; Enterococcus faecalis; Female; Gram-Positive Bacterial Infections; Hospitals; Hospitals, Public; Humans; Kidney Failure, Chronic; Linezolid; Malaysia; Oxazolidinones; Phenotype; Population Surveillance; Time Factors; Vancomycin Resistance | 2006 |
Antistaphylococcal activity of DX-619 alone and in combination with vancomycin, teicoplanin, and linezolid assessed by time-kill synergy testing.
Topics: Acetamides; Anti-Bacterial Agents; Drug Synergism; Drug Therapy, Combination; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Pyrrolidines; Quinolones; Staphylococcus aureus; Teicoplanin; Time Factors; Vancomycin | 2007 |
Serotonin syndrome precipitated by the monoamine oxidase inhibitor linezolid.
Topics: Acetamides; Adult; Anti-Infective Agents; Cyclohexanols; Depressive Disorder, Major; Drug Interactions; Female; Humans; Linezolid; Monoamine Oxidase Inhibitors; Oxazolidinones; Serotonin Syndrome; Venlafaxine Hydrochloride | 2007 |
Simultaneous determination and validation of antimicrobials in plasma and tissue of actinomycetoma by high-performance liquid chromatography with diode array and fluorescence detection.
Topics: Acetamides; Acetonitriles; Amoxicillin; Animals; Anti-Bacterial Agents; Buffers; Chemical Precipitation; Chromatography, High Pressure Liquid; Drug Stability; Fluoroquinolones; Freezing; Hydrogen-Ion Concentration; Linezolid; Mice; Mycetoma; Oxazolidinones; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Sulfamethoxazole; Time Factors; Trimethoprim; Water | 2007 |
Enterococcus faecium as a cause of pulmonary abscesses in kidney transplant recipient.
Topics: Acetamides; Adult; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Kidney Transplantation; Linezolid; Lung Abscess; Male; Oxazolidinones | 2007 |
Linezolid alone and in combination with rifampicin prevents experimental vascular graft infection due to methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Blood Vessel Prosthesis; Drug Synergism; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Prosthesis-Related Infections; Rats; Rats, Wistar; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Teicoplanin | 2007 |
Activity of linezolid against Gram-positive cocci: a multicentre study in Greek hospitals.
Topics: Acetamides; Anti-Infective Agents; Deoxyribonucleases, Type II Site-Specific; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Gram-Positive Cocci; Greece; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2007 |
Economic evaluation of linezolid versus vancomycin in mechanical ventilation-associated nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Infective Agents; Cost-Benefit Analysis; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia, Staphylococcal; Pneumonia, Ventilator-Associated; Staphylococcus aureus; Vancomycin | 2006 |
Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Daptomycin; Female; Linezolid; Luminescent Measurements; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Neutropenia; Oxazolidinones; Peritonitis; Staphylococcus aureus | 2007 |
Linezolid cerebrospinal fluid concentration in central nervous system infection.
Topics: Acetamides; Adult; Aged; Brain Abscess; Cerebral Ventricles; Drug Monitoring; Encephalitis; Female; Humans; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis | 2007 |
The economic effect of oral linezolid versus intravenous vancomycin in the outpatient setting: the payer perspective.
Topics: Acetamides; Adult; Ambulatory Care; Anti-Bacterial Agents; Anti-Infective Agents; Female; Humans; Injections, Intravenous; Insurance Claim Review; Linezolid; Male; Managed Care Programs; Middle Aged; Oxazolidinones; Vancomycin | 2007 |
Oxazolidinones and human immunodeficiency virus.
Topics: Acetamides; Anti-HIV Agents; Drug Interactions; HIV Infections; Humans; Linezolid; Mitochondrial Diseases; Oxazolidinones; Protein Synthesis Inhibitors; Reverse Transcriptase Inhibitors | 2007 |
Decreased serum linezolid levels in a critically ill patient receiving concomitant linezolid and rifampin.
Topics: Acetamides; Adult; Anti-Infective Agents; Critical Care; Drug Interactions; Female; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Rifampin; Staphylococcal Infections; Staphylococcus aureus | 2007 |
Antimicrobial resistance trends among sinus isolates of Streptococcus pneumoniae in the United States (2001-2005).
Topics: Acetamides; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; beta-Lactam Resistance; Cefuroxime; Cephalosporin Resistance; Clindamycin; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Erythromycin; Humans; Levofloxacin; Linezolid; Ofloxacin; Oxazolidinones; Paranasal Sinuses; Penicillin Resistance; Population Surveillance; Streptococcus pneumoniae; Trimethoprim Resistance; Trimethoprim, Sulfamethoxazole Drug Combination; United States | 2007 |
Linezolid therapy for infective endocarditis.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Endocarditis, Bacterial; Female; Follow-Up Studies; Gram-Positive Bacterial Infections; Humans; Infant; Linezolid; Male; Middle Aged; Oxazolidinones; Time Factors; Treatment Outcome | 2007 |
Linezolid resistance in three isolates of coagulase-negative staphylococci.
Topics: Acetamides; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Drug Resistance, Bacterial; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Oxazolidinones; Staphylococcal Infections; Staphylococcus | 2007 |
Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Biofilms; Catheterization, Central Venous; Daptomycin; Humans; Linezolid; Methicillin Resistance; Minocycline; Oxazolidinones; Staphylococcus aureus; Tigecycline | 2007 |
Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis.
Topics: Acetamides; Administration, Oral; Amoxicillin; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Endocarditis, Bacterial; Enterococcus faecalis; Female; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Rats; Rats, Wistar; Vancomycin Resistance | 2007 |
In vitro activity of antimicrobial agents against oxacillin resistant staphylococci with special reference to Staphylococcus haemolyticus.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; India; Linezolid; Microbial Sensitivity Tests; Oxacillin; Oxazolidinones; Staphylococcus; Staphylococcus haemolyticus; Teicoplanin; Vancomycin; Virginiamycin | 2007 |
In vitro efficacy and pharmacodynamic indices for antibiotics against coagulase-negative staphylococcus endophthalmitis isolates.
Topics: Acetamides; Administration, Oral; Administration, Topical; Anti-Bacterial Agents; Aqueous Humor; Aza Compounds; Biological Availability; Coagulase; Endophthalmitis; Eye Infections, Bacterial; Fluoroquinolones; Gatifloxacin; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Microbiological Techniques; Moxifloxacin; Oxazolidinones; Quinolines; Staphylococcal Infections; Staphylococcus; Vancomycin; Virginiamycin | 2007 |
[Linezolid as alternative treatment for vascular prosthesis infections].
Topics: Acetamides; Anti-Bacterial Agents; Aorta, Abdominal; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Ceftazidime; Combined Modality Therapy; Drug Therapy, Combination; Femoral Artery; Humans; Linezolid; Male; Methicillin Resistance; Metronidazole; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus aureus; Suction; Surgical Wound Infection | 2007 |
Use of pyrosequencing to identify point mutations in domain V of 23S rRNA genes of linezolid-resistant Staphylococcus aureus and Staphylococcus epidermidis.
Topics: Acetamides; Anti-Infective Agents; Base Sequence; DNA Primers; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Sequence Data; Oxazolidinones; Point Mutation; Polymorphism, Single Nucleotide; RNA, Ribosomal, 23S; Staphylococcus aureus; Staphylococcus epidermidis | 2007 |
Treatment of vancomycin-resistant Enterococcus faecium ventriculitis in a neonate.
Topics: Acetamides; Anti-Infective Agents; Enterococcus faecium; Female; Humans; Infant, Newborn; Linezolid; Meningitis, Bacterial; Microbial Sensitivity Tests; Oxazolidinones; Premature Birth; Treatment Outcome; Vancomycin Resistance; Ventriculoperitoneal Shunt | 2007 |
Effect of linezolid and teicoplanin on skin staphylococci.
Topics: Acetamides; Anti-Bacterial Agents; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Skin; Staphylococcus aureus; Teicoplanin | 2007 |
In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
Topics: Acetamides; Anti-Infective Agents; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Humans; In Vitro Techniques; Korea; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Pyridines; Staphylococcus; Staphylococcus aureus; Thienopyridines; Thiophenes | 2007 |
Linezolid as rescue therapy for pneumococcal meningitis.
Topics: Acetamides; Aged; Anti-Infective Agents; Female; Humans; Linezolid; Meningitis, Pneumococcal; Middle Aged; Oxazolidinones; Salvage Therapy | 2007 |
Dose dependence of emergence of resistance to linezolid in Enterococcus faecalis in vivo.
Topics: Acetamides; Animals; Anti-Infective Agents; Chromatography, High Pressure Liquid; Disease Models, Animal; DNA Primers; Drug Resistance, Bacterial; Enterococcus faecalis; Gram-Positive Bacterial Infections; Linezolid; Mice; Oxazolidinones; RNA, Bacterial; RNA, Ribosomal; RNA, Ribosomal, 16S; RNA, Ribosomal, 5S | 2007 |
[Appropriate use of anti-MRSA drugs (discussion)].
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Community-Acquired Infections; Cross Infection; Dibekacin; Humans; Immunocompromised Host; Linezolid; Methicillin Resistance; Oxazolidinones; Practice Guidelines as Topic; Staphylococcus aureus; Teicoplanin; Vancomycin | 2007 |
The post-antibiotic effects of linezolid against Gram-positive pathogens.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Humans; Linezolid; Oxazolidinones; Staphylococcus aureus; Staphylococcus epidermidis; Time Factors; Turkey | 2007 |
Severe lactic acidosis associated with linezolid use in a patient with the mitochondrial DNA A2706G polymorphism.
Topics: Acetamides; Acidosis, Lactic; Adult; Anti-Infective Agents; DNA, Mitochondrial; Female; Genetic Predisposition to Disease; Humans; Linezolid; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Oxazolidinones; Polymorphism, Genetic | 2007 |
Methicillin-resistant Staphylococcus aureus pneumonia after thoracic surgery: successful treatment with linezolid after failed vancomycin therapy.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Cross Infection; Female; Humans; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Pneumonia, Staphylococcal; Staphylococcus aureus; Thoracic Surgical Procedures; Treatment Failure; Treatment Outcome; Vancomycin | 2007 |
Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid.
Topics: Acetamides; Aged; Aged, 80 and over; Anemia; Anti-Infective Agents; Blood Glucose; Cohort Studies; Creatinine; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Platelet Count; Pyridoxine; Retrospective Studies; Rifampin; Thrombocytopenia | 2007 |
Cost-effectiveness analysis of linezolid compared with vancomycin for the treatment of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cost-Benefit Analysis; Cross Infection; Decision Support Techniques; Dose-Response Relationship, Drug; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia, Staphylococcal; Randomized Controlled Trials as Topic; Research Design; Retrospective Studies; Staphylococcus aureus; Survival Rate; Vancomycin | 2007 |
Cost-effectiveness analysis of linezolid compared with vancomycin for the treatment of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cost-Benefit Analysis; Cross Infection; Disclosure; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Peer Review, Research; Pneumonia, Staphylococcal; Research Design; Staphylococcus aureus; Vancomycin | 2007 |
In vitro activity of linezolid and 12 other antimicrobials against coryneform bacteria.
Topics: Acetamides; Anti-Bacterial Agents; beta-Lactams; Corynebacterium; Drug Resistance, Bacterial; Fluoroquinolones; Glycopeptides; In Vitro Techniques; Linezolid; Macrolides; Microbial Sensitivity Tests; Oxazolidinones | 2007 |
Detection of mutations conferring resistance to linezolid in Enterococcus spp. by fluorescence in situ hybridization.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus; In Situ Hybridization, Fluorescence; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Sensitivity and Specificity | 2007 |
Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study.
Topics: Acetamides; Algorithms; Animals; Anti-Infective Agents; Antidepressive Agents; Benzodiazepines; Chromans; Diltiazem; Drug Evaluation, Preclinical; Hypoglycemic Agents; Linezolid; Liver; Mice; Models, Biological; Oxazolidinones; Pharmacokinetics; Principal Component Analysis; Rats; Rodentia; Thiazolidinediones; Tissue Distribution; Troglitazone; Zidovudine | 2007 |
Determination of linezolid in growth media by high-performance liquid chromatography with on-line extraction.
Topics: Acetamides; Anti-Infective Agents; Calibration; Chromatography, High Pressure Liquid; Culture Media; Linezolid; Oxazolidinones; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2007 |
The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria.
Topics: Acetamides; Anti-Infective Agents; Binding Sites; Cross-Linking Reagents; Cytoplasm; Drug Resistance; Escherichia coli; Humans; Linezolid; Mitochondria; Models, Molecular; Molecular Structure; Mutation; Oxazolidinones; Peptidyl Transferases; Protein Synthesis Inhibitors; RNA, Bacterial; RNA, Ribosomal; RNA, Ribosomal, 23S; RNA, Transfer, Amino Acyl; Software; Staining and Labeling; Staphylococcus aureus | 2007 |
Linezolid-induced posterior reversible leukoencephalopathy syndrome.
Topics: Acetamides; Aged; Anti-Infective Agents; Blood-Brain Barrier; Brain Diseases; Female; Humans; Hypertensive Encephalopathy; Infections; Linezolid; Magnetic Resonance Imaging; Oxazolidinones | 2007 |
Linezolid in the treatment of implant-related chronic osteomyelitis.
Topics: Acetamides; Aged; Anti-Infective Agents; Chronic Disease; Comorbidity; Debridement; Device Removal; Female; Humans; Internal Fixators; Joint Prosthesis; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones; Prosthesis-Related Infections; Retrospective Studies | 2007 |
[Vancomycin resistant enterococci in etiology of neutropenic enterocolitis: prophylaxis, clinical signs and treatment].
Topics: Acetamides; Adolescent; Adult; Anti-Infective Agents; Antineoplastic Agents; Drug Resistance, Bacterial; Enterococcus; Enterocolitis; Feces; Gram-Positive Bacterial Infections; Hematologic Neoplasms; Hemorrhage; Humans; Linezolid; Middle Aged; Neutropenia; Oxazolidinones; Vancomycin | 2006 |
Secular trends in severe renal failure associated with the use of new antimicrobial agents in critically ill surgical patients.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Caspofungin; Cohort Studies; Critical Illness; Echinocandins; Female; Humans; Intensive Care Units; Linezolid; Lipopeptides; Male; Middle Aged; Oxazolidinones; Peptides, Cyclic; Postoperative Complications; Pyrimidines; Renal Insufficiency; Renal Replacement Therapy; Retrospective Studies; Triazoles; Voriconazole | 2007 |
Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; DNA Transposable Elements; Drug Resistance, Bacterial; Humans; Linezolid; Methicillin Resistance; Methyltransferases; Microbial Sensitivity Tests; Molecular Sequence Data; Operon; Oxazolidinones; Plasmids; Protein Synthesis Inhibitors; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcus aureus | 2007 |
Detection of vancomycin heteroresistant Staphylococcus haemolyticus and vancomycin intermediate resistant Staphylococcus epidermidis by means of vancomycin screening agar.
Topics: Acetamides; Acute Disease; Adult; Agar; Anti-Bacterial Agents; Bone Marrow Transplantation; Drug Resistance; Humans; Immunocompromised Host; Leukemia, Myeloid; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Staphylococcus haemolyticus; Vancomycin | 2007 |
[Anemia and peripheral neuropathy associated with linezolid].
Topics: Acetamides; Anemia; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Peripheral Nervous System Diseases | 2007 |
Efficacy and safety of linezolid for Gram-positive orthopedic infections: a prospective case series.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Chronic Disease; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Orthopedics; Osteomyelitis; Oxazolidinones; Prospective Studies; Prosthesis-Related Infections; Treatment Outcome | 2007 |
A comparison of costs and hospital length of stay associated with intravenous/oral linezolid or intravenous vancomycin treatment of complicated skin and soft-tissue infections caused by suspected or confirmed methicillin-resistant Staphylococcus aureus in
Topics: Acetamides; Administration, Oral; Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Health Care Costs; Hospitalization; Humans; Injections, Intravenous; Length of Stay; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Soft Tissue Infections; Staphylococcal Skin Infections; Staphylococcus aureus; United States; Vancomycin | 2007 |
Colonization by a linezolid-resistant Enterococcus faecalis caused a urinary tract infection.
Topics: Acetamides; Drug Resistance, Bacterial; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Urinary Tract Infections | 2007 |
Early switch from vancomycin to oral linezolid for treatment of gram-positive heart valve endocarditis.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Drug Resistance, Bacterial; Endocarditis, Bacterial; Female; Gram-Positive Bacterial Infections; Health Care Costs; Heart Valve Diseases; Heart Valve Prosthesis; Humans; Length of Stay; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Vancomycin | 2007 |
In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Area Under Curve; Ceftaroline; Cephalosporins; Chromatography, High Pressure Liquid; Colony Count, Microbial; Endocarditis, Bacterial; Immunoenzyme Techniques; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin; Vancomycin Resistance | 2007 |
AM-7359--a novel oxazolidinone with low resistance potential and potent activity against drug resistant pathogens.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus | 2007 |
Successful treatment with linezolid of meningitis complicated with subdural empyema in a 6-month-old boy.
Topics: Acetamides; Anti-Infective Agents; Empyema, Subdural; Humans; Infant; Linezolid; Male; Meningitis, Bacterial; Oxazolidinones | 2007 |
First report in Spain of linezolid non-susceptibility in a clinical isolate of Staphylococcus haemolyticus.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Drug Resistance, Bacterial; Humans; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Spain; Staphylococcal Infections; Staphylococcus haemolyticus; Wound Infection; Wounds, Gunshot | 2007 |
In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Dose-Response Relationship, Drug; Injections, Intravenous; Linezolid; Methicillin Resistance; Mice; Mice, Inbred C3H; Oxazolidinones; Staphylococcal Infections | 2007 |
Synthesis and in vitro antibacterial activities of novel oxazolidinones.
Topics: Acetamides; Anti-Bacterial Agents; Drug Design; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Staphylococcus aureus; Structure-Activity Relationship | 2008 |
Cost-effectiveness analysis of linezolid compared with vancomycin for the treatment of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cost-Benefit Analysis; Cross Infection; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Pneumonia, Staphylococcal; Staphylococcus aureus; Vancomycin | 2007 |
Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position.
Topics: Acetamides; Anti-Bacterial Agents; Chemistry, Pharmaceutical; Drug Design; Drug Resistance, Bacterial; Gram-Negative Bacteria; Linezolid; Mass Spectrometry; Methicillin; Microbial Sensitivity Tests; Models, Chemical; Oxazolidinones; Piperazine; Piperazines; Sulfur; Temperature; Thiocarbamates | 2007 |
Vancomycin MIC creep in non-vancomycin-intermediate Staphylococcus aureus (VISA), vancomycin-susceptible clinical methicillin-resistant S. aureus (MRSA) blood isolates from 2001-05.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxacillin; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Time Factors; Vancomycin | 2007 |
Persistence of rRNA operon mutated copies and rapid re-emergence of linezolid resistance in Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Novobiocin; Operon; Oxazolidinones; RNA, Bacterial; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus | 2007 |
Successful treatment of vancomycin-resistant enterococcus ventriculitis in a child.
Topics: Acetamides; Anti-Infective Agents; Cerebral Ventricles; Encephalitis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Hydrocephalus; Infant; Linezolid; Male; Oxazolidinones; Treatment Outcome; Vancomycin Resistance; Ventriculoperitoneal Shunt | 2007 |
Accuracy of six antimicrobial susceptibility methods for testing linezolid against staphylococci and enterococci.
Topics: Acetamides; Anti-Bacterial Agents; Diagnostic Errors; Drug Resistance, Bacterial; Enterococcus; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Reproducibility of Results; Staphylococcus | 2007 |
Dissemination of a localized cutaneous infection with Mycobacterium chelonae under immunosuppressive treatment.
Topics: Acetamides; Anti-Infective Agents; Clarithromycin; Diagnosis, Differential; Female; Humans; Immunocompromised Host; Linezolid; Middle Aged; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Oxazolidinones; Skin Ulcer | 2007 |
Evaluation of the in vitro activity of tigecycline against multiresistant Gram-positive cocci containing tetracycline resistance determinants.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterococcus; Genes, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Staphylococcus; Streptococcus; Tetracycline Resistance; Tigecycline; Virginiamycin | 2008 |
Linezolid versus vancomycin for prosthetic joint infections: a cost analysis.
Topics: Acetamides; Administration, Oral; Algorithms; Anti-Bacterial Agents; Costs and Cost Analysis; Gram-Positive Bacterial Infections; Health Care Costs; Home Care Services; Humans; Infusions, Intravenous; Joint Prosthesis; Linezolid; Methicillin Resistance; Oxazolidinones; Prosthesis-Related Infections; Vancomycin | 2007 |
Treatment of meningitis caused by methicillin-resistant Staphylococcus aureus with linezolid.
Topics: Acetamides; Anesthesia, Epidural; Anti-Bacterial Agents; Cross Infection; Drug Resistance, Multiple, Bacterial; Female; Humans; Infusions, Intravenous; Linezolid; Meningitis, Bacterial; Methicillin Resistance; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2007 |
Linezolid-related pancytopenia in organ-transplant patients: report of two cases.
Topics: Acetamides; Adult; Anti-Infective Agents; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pancytopenia; Peritonitis; Pressure Ulcer; Transplants | 2007 |
Sequential linezolid-resistant Staphylococcus epidermidis isolates with G2576T mutation.
Topics: Acetamides; Aged; Anti-Infective Agents; Bacteremia; Drug Resistance, Bacterial; Humans; Linezolid; Male; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Staphylococcus epidermidis | 2007 |
Linezolid tissue penetration and serum activity against strains of methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility in diabetic patients with foot infections.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Diabetes Complications; Drug Resistance, Multiple, Bacterial; Female; Foot Diseases; Humans; Linezolid; Male; Methicillin Resistance; Microbial Viability; Middle Aged; Oxazolidinones; Peripheral Vascular Diseases; Serum; Serum Bactericidal Test; Skin; Staphylococcal Skin Infections; Staphylococcus aureus; Time Factors; Vancomycin Resistance | 2007 |
[Use of a new antibiotic in Norway].
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Drug Hypersensitivity; Drug Monitoring; Drug Resistance, Multiple, Bacterial; Drug Utilization; Female; Humans; Linezolid; Male; Norway; Oxazolidinones; Staphylococcal Infections; Streptococcal Infections | 2007 |
Activities of clindamycin, synercid, telithromycin, linezolid, and mupirocin against Gram-positive coccal strains resistant to erythromycin in Korea.
Topics: Acetamides; Anti-Bacterial Agents; Clindamycin; Drug Resistance, Bacterial; Erythromycin; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Ketolides; Korea; Linezolid; Microbial Sensitivity Tests; Mupirocin; Oxazolidinones; Virginiamycin | 2007 |
LEADER surveillance program results for 2006: an activity and spectrum analysis of linezolid using clinical isolates from the United States (50 medical centers).
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Sentinel Surveillance; Staphylococcus aureus; Streptococcus; United States | 2007 |
Novel substituted (pyridin-3-yl)phenyloxazolidinones: antibacterial agents with reduced activity against monoamine oxidase A and increased solubility.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Dogs; Drug Resistance, Bacterial; Gram-Positive Bacteria; Humans; Linezolid; Mice; Microbial Sensitivity Tests; Microsomes, Liver; Models, Molecular; Monoamine Oxidase; Oxazolidinones; Pneumonia, Pneumococcal; Pyridines; Rats; Rats, Wistar; Solubility; Streptococcus pneumoniae; Structure-Activity Relationship | 2007 |
Gut overgrowth of vancomycin-resistant enterococci (VRE) results in linezolid-resistant mutation in a child with severe congenital neutropenia: a case report.
Topics: Acetamides; Anti-Bacterial Agents; Child; Drug Resistance, Multiple, Bacterial; Enterococcus; Humans; Intestines; Linezolid; Mutation; Neutropenia; Oxazolidinones; Protein Synthesis Inhibitors; Stem Cell Transplantation; Streptococcal Infections; Vancomycin; Vancomycin Resistance | 2007 |
Painful neuropathy with skin denervation after prolonged use of linezolid.
Topics: Acetamides; Anti-Infective Agents; Biopsy; Epidermis; Female; Humans; Linezolid; Middle Aged; Neural Conduction; Oxazolidinones; Pain; Sensory Receptor Cells; Skin; Streptococcal Infections; Time Factors | 2008 |
Cerebrospinal fluid penetration and bacteriostatic activity of linezolid against Enterococcus faecalis in a child with a ventriculoperitoneal shunt infection.
Topics: Acetamides; Child; Enterococcus faecalis; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Ventriculoperitoneal Shunt | 2007 |
Disposition of linezolid in the isolated rat lung after systemic and pulmonary drug delivery.
Topics: Acetamides; Administration, Inhalation; Animals; Anti-Infective Agents; Bronchoalveolar Lavage Fluid; Linezolid; Lung; Male; Oxazolidinones; Rats; Rats, Wistar; Tissue Distribution | 2007 |
Postoperative vancomycin-resistant Enterococcus faecium endophthalmitis.
Topics: Acetamides; Aged; Anti-Infective Agents; Aqueous Humor; Cornea; Endophthalmitis; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Keratoplasty, Penetrating; Linezolid; Oxazolidinones; Postoperative Complications; Tissue Donors; Vancomycin Resistance; Vitreous Body | 2007 |
Susceptibility to daptomycin, quinupristin-dalfopristin and linezolid and some other antibiotics in clinical isolates of methicillin resistant and methicillin sensitive S.aureus from the Oslo area.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Humans; Linezolid; Methicillin Resistance; Norway; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Virginiamycin | 2007 |
Economic evaluation of linezolid versus teicoplanin for the treatment of infections caused by gram-positive microorganisms in Spain.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Cost-Benefit Analysis; Female; Gram-Positive Bacterial Infections; Health Care Costs; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Spain; Teicoplanin | 2007 |
A simple isocratic HPLC assay to determine linezolid concentrations in different biomatrices for in vivo and in vitro studies.
Topics: Acetamides; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Humans; Linezolid; Oxazolidinones; Reproducibility of Results | 2007 |
Elucidation of the RNA target of linezolid by using a linezolid-neomycin B heteroconjugate and genomic SELEX.
Topics: Acetamides; Base Sequence; Binding Sites; Biotin; Drug Delivery Systems; Escherichia coli; Framycetin; Linezolid; Molecular Sequence Data; Molecular Structure; Oxazolidinones; Protein Synthesis Inhibitors; RNA Probes; SELEX Aptamer Technique | 2007 |
Vancomycin-resistant VanA phenotype Enterococcus faecalis: first case in Minas Gerais state and epidemiological considerations.
Topics: Acetamides; Adult; Anti-Infective Agents; Brazil; Cross Infection; Enterococcus faecalis; Female; Genotype; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Phenotype; Vancomycin Resistance | 2007 |
Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Multiple, Bacterial; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Pyridines; Staphylococcus aureus; Thienopyridines; Thiophenes; Virginiamycin | 2007 |
Successful treatment of methicillin-resistant Staphylococcus aureus meningitis using linezolid without removal of intrathecal infusion pump. Case report.
Topics: Acetamides; Aged; Anti-Infective Agents; Baclofen; Female; Humans; Infusion Pumps, Implantable; Linezolid; Meningitis, Bacterial; Methicillin Resistance; Muscle Relaxants, Central; Oxazolidinones; Staphylococcus aureus | 2007 |
Successful recovery after disseminated infection due to mycobacterium abscessus in a lung transplant patient: subcutaneous nodule as first manifestation--a case report.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Cystic Fibrosis; Humans; Linezolid; Lung Transplantation; Male; Mycobacterium; Mycobacterium Infections; Oxazolidinones; Postoperative Complications; Sputum | 2007 |
Emergence of increasing linezolid-resistance in enterococci in a post-outbreak situation with vancomycin-resistant Enterococcus faecium.
Topics: Acetamides; Anti-Bacterial Agents; Disease Outbreaks; Drug Resistance, Bacterial; Enterococcus faecium; Germany; Hospitals, University; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Protein Synthesis Inhibitors; Vancomycin Resistance | 2008 |
[Proper use of antibiotics: a prospective study on the use of linezolid in a French university hospital].
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Clinical Trials as Topic; Cohort Studies; Endocarditis; France; Hospitals, University; Humans; Linezolid; Oxazolidinones; Pneumonia | 2007 |
Zyvox Annual Appraisal of Potency and Spectrum Program Results for 2006: an activity and spectrum analysis of linezolid using clinical isolates from 16 countries.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Global Health; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Population Surveillance | 2007 |
Effects of tigecycline, linezolid and vancomycin on biofilms of viridans streptococci isolates from patients with endocarditis.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Biofilms; Dose-Response Relationship, Drug; Endocarditis, Bacterial; Female; Heart Valve Prosthesis; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Minocycline; Oxazolidinones; Prosthesis-Related Infections; Streptococcal Infections; Tigecycline; Treatment Outcome; Vancomycin; Viridans Streptococci | 2007 |
Importance of the efflux pump systems in the resistance of Mycobacterium tuberculosis to fluoroquinolones and linezolid.
Topics: Acetamides; Anti-Bacterial Agents; DNA Gyrase; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Humans; Ion Pumps; Linezolid; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis | 2007 |
Linezolid- and vancomycin-resistant Enterococcus faecium endocarditis: successful treatment with tigecycline and daptomycin.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Drug Therapy, Combination; Endocarditis, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Minocycline; Oxazolidinones; Tigecycline; Treatment Outcome; Vancomycin | 2007 |
Phylogenetic analysis of vancomycin-resistant Enterococcus faecium genotypes associated with outbreaks or sporadic infections in Italy.
Topics: Acetamides; Animals; Anti-Infective Agents; Disease Outbreaks; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecium; Genotype; Gram-Positive Bacterial Infections; Humans; Italy; Linezolid; Oxazolidinones; Phylogeny; Sequence Analysis, DNA; Vancomycin Resistance; Virulence Factors | 2007 |
Relapsing Rhodococcus equi infection in a heart transplant recipient successfully treated with long-term linezolid.
Topics: Acetamides; Actinomycetales Infections; Anti-Bacterial Agents; Cryptococcosis; Cryptococcus neoformans; Drug Resistance, Bacterial; Fluconazole; Heart Diseases; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Recurrence; Rhodococcus equi; Transplantation; Treatment Outcome | 2008 |
Antibiotics for the eradication of Propionibacterium acnes biofilms in surgical infection.
Topics: Acetamides; Anti-Bacterial Agents; Biofilms; Cerebrospinal Fluid Shunts; Colony Count, Microbial; Gram-Positive Bacterial Infections; Humans; Hydrocephalus; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Penicillin G; Propionibacterium acnes; Rifampin; Surgical Wound Infection; Titanium | 2007 |
Polymorphism of linezolid: a combined single-crystal, powder diffraction and NMR study.
Topics: Acetamides; Anti-Infective Agents; Calorimetry, Differential Scanning; Crystallization; Linezolid; Magnetic Resonance Spectroscopy; Oxazolidinones; Phase Transition; Powder Diffraction; Thermodynamics; X-Ray Diffraction | 2008 |
Experience with linezolid therapy in children with osteoarticular infections.
Topics: Acetamides; Adolescent; Anti-Infective Agents; Arthritis, Infectious; Child; Child, Preschool; Community-Acquired Infections; Drug Resistance, Bacterial; Female; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Infant; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Osteomyelitis; Oxazolidinones; Staphylococcus aureus; Treatment Outcome | 2007 |
Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Biological Availability; Cyclic S-Oxides; Dogs; Drug Resistance, Bacterial; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Injections, Intravenous; Linezolid; Male; Mice; Microbial Sensitivity Tests; Monoamine Oxidase Inhibitors; Oxazolidinones; Rats; Rats, Sprague-Dawley; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes; Structure-Activity Relationship | 2007 |
Determination of risk factors associated with isolation of linezolid-resistant strains of vancomycin-resistant Enterococcus.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Case-Control Studies; Cross Infection; Disease Transmission, Infectious; Drug Resistance, Multiple, Bacterial; Enterococcus; Female; Gram-Positive Bacterial Infections; Hospitals, University; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Parenteral Nutrition, Total; Peripheral Vascular Diseases; Retrospective Studies; Risk Factors; Transplants; Vancomycin Resistance | 2007 |
Preseptal cellulitis caused by community acquired methicillin resistant Staphylococcus aureus (CAMRSA).
Topics: Acetamides; Administration, Oral; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Community-Acquired Infections; Drug Therapy, Combination; Football; Humans; Linezolid; Male; Methicillin Resistance; Ophthalmic Solutions; Orbital Cellulitis; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2007 |
Update on prevalence and treatment of methicillin-resistant Staphylococcus aureus infections.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Cephalosporins; Clindamycin; Daptomycin; Doxycycline; Folic Acid Antagonists; Global Health; Glycopeptides; Humans; Linezolid; Lipoglycopeptides; Methicillin; Methicillin Resistance; Minocycline; Oxazolidinones; Prevalence; Staphylococcal Infections; Staphylococcus aureus; Sulfamethoxazole; Teicoplanin; Tigecycline; Trimethoprim; Vancomycin | 2007 |
Linezolid-induced interstitial nephritis in a kidney-transplant patient.
Topics: Acetamides; Anti-Infective Agents; Cell Count; Creatinine; Humans; Kidney Transplantation; Kidney Tubules; Linezolid; Male; Middle Aged; Nephritis, Interstitial; Oxazolidinones | 2007 |
Antimicrobial activity of mupirocin, daptomycin, linezolid, quinupristin/dalfopristin and tigecycline against vancomycin-resistant enterococci (VRE) from clinical isolates in Korea (1998 and 2005).
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Korea; Linezolid; Microbial Sensitivity Tests; Minocycline; Mupirocin; Oxazolidinones; Tigecycline; Vancomycin Resistance; Virginiamycin | 2007 |
In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants.
Topics: Acetamides; Anti-Infective Agents; Base Sequence; Drug Resistance, Bacterial; Genotype; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Mycobacterium tuberculosis; Nucleic Acid Conformation; Oxazolidinones; RNA, Ribosomal, 23S; Selection, Genetic; Sequence Analysis, DNA | 2008 |
Comparative bactericidal activities of daptomycin, glycopeptides, linezolid and tigecycline against blood isolates of Gram-positive bacteria in Taiwan.
Topics: Acetamides; Anti-Infective Agents; Daptomycin; Drug Resistance, Bacterial; Drug Therapy, Combination; Glycopeptides; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Staphylococcus aureus; Streptococcaceae; Taiwan; Teicoplanin; Tigecycline; Time Factors; Vancomycin | 2008 |
Pharmacodynamic comparison of linezolid, teicoplanin and vancomycin against clinical isolates of Staphylococcus aureus and coagulase-negative staphylococci collected from hospitals in Brazil.
Topics: Acetamides; Anti-Infective Agents; Area Under Curve; Brazil; Coagulase; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Models, Biological; Monte Carlo Method; Oxazolidinones; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Teicoplanin; Vancomycin | 2008 |
Health care-associated endocarditis caused by Staphylococcus aureus with reduced susceptibility to vancomycin.
Topics: Acetamides; Anti-Bacterial Agents; Child, Preschool; Cross Infection; Endocarditis, Bacterial; Female; Fusidic Acid; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance | 2008 |
Activities of Linezolid against nontuberculous mycobacteria.
Topics: Acetamides; Anti-Infective Agents; Endpoint Determination; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Oxazolidinones; Species Specificity; Turkey | 2007 |
Tc-99m HMPAO labeled white blood cell imaging in a child with eosinophilic lung disease.
Topics: Acetamides; Anti-Infective Agents; Child, Preschool; Humans; Leukemia, Myeloid, Acute; Leukocytes; Linezolid; Magnetic Resonance Imaging; Male; Oxazolidinones; Pulmonary Eosinophilia; Radionuclide Imaging; Radiopharmaceuticals; Staphylococcal Infections; Technetium Tc 99m Exametazime | 2008 |
Pharmacokinetics of linezolid in bone tissue investigated by in vivo microdialysis.
Topics: Acetamides; Animals; Anti-Infective Agents; Bone and Bones; Feasibility Studies; Female; Infusions, Intravenous; Linezolid; Microdialysis; Oxazolidinones; Sus scrofa; Tissue Distribution | 2008 |
Efficacy of linezolid in the treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus: an experimental study.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Linezolid; Male; Mediastinitis; Methicillin Resistance; Oxazolidinones; Rats; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Surgical Wound Infection | 2008 |
Determination of enantiomeric impurity of linezolid by capillary electrophoresis using heptakis-(2,3-diacetyl-6-sulfato)-beta-cyclodextrin.
Topics: Acetamides; beta-Cyclodextrins; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Linezolid; Oxazolidinones; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2008 |
Emergence of linezolid resistance in a methicillin resistant Staphylococcus aureus strain.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Humans; Leukemia, Myeloid, Acute; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2008 |
Linezolid in postneurosurgical infections.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Central Nervous System Bacterial Infections; Female; Humans; Linezolid; Male; Middle Aged; Neurosurgical Procedures; Oxazolidinones; Postoperative Complications; Staphylococcal Infections | 2008 |
Impact of the more-potent antibiotics quinupristin-dalfopristin and linezolid on outcome measure of patients with vancomycin-resistant Enterococcus bacteremia.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacteremia; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Oxazolidinones; Retrospective Studies; Treatment Outcome; Vancomycin Resistance; Virginiamycin | 2008 |
Serotonin syndrome after concomitant treatment with linezolid and meperidine.
Topics: Acetamides; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Interactions; Drug Therapy, Combination; Humans; Leukemia, Myeloid, Acute; Linezolid; Male; Meperidine; Oxazolidinones; Serotonin Syndrome | 2008 |
[Our experience with linesolid usage in newborn children].
Topics: Acetamides; Anti-Bacterial Agents; Drug Administration Schedule; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Infant, Newborn; Linezolid; Oxazolidinones; Treatment Outcome; Vancomycin Resistance | 2007 |
The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer.
Topics: Acetamides; Adult; Aged; Female; Hematologic Diseases; Humans; Linezolid; Male; Middle Aged; Neoplasms; Oxazolidinones; Vitamin B 6 | 2008 |
Clinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferase.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Chloramphenicol; Colombia; Contact Tracing; Cross Infection; Drug Resistance, Bacterial; Family Characteristics; Fatal Outcome; Female; Humans; Linezolid; Methicillin Resistance; Methyltransferases; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus; Thiamphenicol | 2008 |
In vitro activity of fosfomycin tromethamine and linezolid against vancomycin-resistant Enterococcus faecium isolates.
Topics: Acetamides; Cross Infection; Enterococcus faecium; Fosfomycin; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin Resistance | 2008 |
Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Diterpenes; Drug Resistance, Multiple, Bacterial; Linezolid; Models, Molecular; Oxazolidinones; Peptidyl Transferases; Point Mutation; Polymerase Chain Reaction; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Analysis, DNA; Staphylococcus aureus | 2008 |
Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gene Dosage; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus | 2008 |
Response to emerging infection leading to outbreak of linezolid-resistant enterococci.
Topics: Acetamides; Anti-Infective Agents; Case-Control Studies; Colony Count, Microbial; Communicable Diseases, Emerging; Cross Infection; Disease Outbreaks; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Hospital Mortality; Humans; Length of Stay; Linezolid; Microbial Sensitivity Tests; Multivariate Analysis; Oxazolidinones; Vancomycin Resistance | 2007 |
Selection of linezolid-resistant Enterococcus faecium in an in vitro dynamic model: protective effect of doxycycline.
Topics: Acetamides; Doxycycline; Drug Resistance, Bacterial; Enterococcus faecium; Humans; Linezolid; Microbial Sensitivity Tests; Models, Biological; Oxazolidinones | 2008 |
Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by Nocardia brasiliensis.
Topics: Acetamides; Actinomycosis; Animals; Disease Models, Animal; Linezolid; Mice; Mice, Inbred BALB C; Mycetoma; Nocardia; Nocardia Infections; Organophosphates; Oxazoles; Oxazolidinones; Prodrugs; Tetrazoles; Treatment Outcome | 2008 |
Effect of antibiotics, alone and in combination, on Panton-Valentine leukocidin production by a Staphylococcus aureus reference strain.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Toxins; Clindamycin; Drug Synergism; Drug Therapy, Combination; Exotoxins; Fusidic Acid; Gene Expression Regulation, Bacterial; Humans; Leukocidins; Linezolid; Microbial Sensitivity Tests; Oxacillin; Oxazolidinones; Reference Standards; Rifampin; Staphylococcus aureus | 2008 |
Linezolid for treatment of subdural empyema due to Streptococcus: case reports.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Brain Neoplasms; Drainage; Empyema, Subdural; Facial Injuries; Female; Humans; Linezolid; Magnetic Resonance Imaging; Male; Middle Aged; Mydriasis; Neurosurgical Procedures; Oxazolidinones; Paresis; Seizures; Streptococcal Infections; Subdural Space; Vancomycin | 2009 |
Post-antibiotic effects of linezolid and other agents against Mycobacterium tuberculosis.
Topics: Acetamides; Antitubercular Agents; Drug Combinations; Drug Resistance, Multiple, Bacterial; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Rifampin | 2008 |
An outbreak of colonization with linezolid-resistant Staphylococcus epidermidis in an intensive therapy unit.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cross Infection; Disease Outbreaks; DNA Fingerprinting; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Environmental Microbiology; Female; Genotype; Humans; Infection Control; Intensive Care Units; Linezolid; Male; Middle Aged; Oxazolidinones; Point Mutation; Polymerase Chain Reaction; Staphylococcal Infections; Staphylococcus epidermidis | 2008 |
The use of linezolid in the treatment of infected total joint arthroplasty.
Topics: Acetamides; Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Female; Follow-Up Studies; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Reoperation; Retrospective Studies; Surgical Wound Infection; Treatment Outcome | 2008 |
Linezolid in the treatment of 'difficult' multidrug-resistant tuberculosis.
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Oxazolidinones; Sputum; Tuberculosis, Multidrug-Resistant; Tuberculosis, Spinal | 2008 |
In vivo therapeutic effect of gatifloxacin on BALB/c mice infected with Nocardia brasiliensis.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Female; Fluoroquinolones; Gatifloxacin; Humans; Linezolid; Mice; Mice, Inbred BALB C; Nocardia; Nocardia Infections; Oxazolidinones; Treatment Outcome | 2008 |
Determination of linezolid and its achiral impurities using sweeping preconcentration by micellar capillary electrophoresis.
Topics: Acetamides; Drug Contamination; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Linezolid; Oxazolidinones; Sensitivity and Specificity | 2008 |
[Marked hyponatremia with consciousness disturbance probably caused by linezolid in a patient with acute myeloid leukemia].
Topics: Acetamides; Aged; Anti-Infective Agents; Consciousness Disorders; Humans; Hyponatremia; Leukemia, Myeloid, Acute; Linezolid; Male; Oxazolidinones; Sepsis | 2008 |
Ciprofloxacin-induced Q-T interval prolongation.
Topics: Abscess; Acetamides; Adolescent; Anti-Infective Agents; Aztreonam; Bradycardia; Ciprofloxacin; Crohn Disease; Humans; Infusions, Intravenous; Linezolid; Long QT Syndrome; Male; Metronidazole; Oxazolidinones; Randomized Controlled Trials as Topic | 2008 |
Linezolid for tympanostomy tube otorrhea caused by methicillin-resistant Staphylococcus aureus and multiple drug-resistant Streptococcus pneumoniae.
Topics: Acetamides; Administration, Oral; Adolescent; Anti-Infective Agents; Child; Child, Preschool; Drug Resistance, Multiple, Bacterial; Female; Humans; Infant; Linezolid; Male; Methicillin Resistance; Middle Ear Ventilation; Otitis Media with Effusion; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae | 2008 |
Relationship of linezolid minimum inhibitory concentration and time to bacterial eradication in treatment for methicillin-resistant Staphylococcus aureus infection.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Retrospective Studies; Staphylococcal Infections; Staphylococcus aureus; Time Factors | 2008 |
Linezolid lock prophylaxis of central venous catheter infection.
Topics: Acetamides; Adult; Anti-Infective Agents; Antibiotic Prophylaxis; Bacteremia; Catheterization, Central Venous; Catheters, Indwelling; Coagulase; Humans; Linezolid; Male; Oxazolidinones; Short Bowel Syndrome; Staphylococcal Infections; Staphylococcus; Treatment Outcome | 2008 |
[Linezolid and tuberculosis, a new and useful treatment].
Topics: Acetamides; Anti-Infective Agents; Female; Humans; Infant; Linezolid; Oxazolidinones; Tuberculosis | 2008 |
Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Culture Media; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Fusidic Acid; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Recombination, Genetic; Rifampin; RNA, Ribosomal, 23S; Staphylococcus aureus; Time Factors | 2008 |
Increasing incidence of linezolid-intermediate or -resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Incidence; Linezolid; Molecular Epidemiology; Mutation; Oxazolidinones; Vancomycin Resistance | 2008 |
In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis complex isolated in Taiwan over 10 years.
Topics: Acetamides; Antitubercular Agents; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Taiwan; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2008 |
First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Proteins; Drug Resistance, Bacterial; Humans; Linezolid; Methyltransferases; Microbial Sensitivity Tests; Molecular Sequence Data; Oxazolidinones; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis | 2008 |
Antimicrobial properties and elution kinetics of linezolid-loaded hip spacers in vitro.
Topics: Acetamides; Anti-Infective Agents; Arthroplasty, Replacement, Hip; Bone Cements; Gentamicins; Hip Prosthesis; Kinetics; Linezolid; Materials Testing; Oxazolidinones; Staphylococcus aureus | 2008 |
A comparative in-vitro evaluation of resistance selection after exposure to teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin in Staphylococcus aureus and Enterococcus spp.
Topics: Acetamides; Anti-Bacterial Agents; Colony Count, Microbial; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Selection, Genetic; Staphylococcus aureus; Teicoplanin; Vancomycin; Virginiamycin | 2008 |
Activities of clindamycin, daptomycin, doxycycline, linezolid, trimethoprim-sulfamethoxazole, and vancomycin against community-associated methicillin-resistant Staphylococcus aureus with inducible clindamycin resistance in murine thigh infection and in vi
Topics: Acetamides; Animals; Anti-Bacterial Agents; Clindamycin; Colony Count, Microbial; Community-Acquired Infections; Culture Media; Daptomycin; Disease Models, Animal; Doxycycline; Drug Resistance, Bacterial; Humans; Linezolid; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Thigh; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin | 2008 |
Molecular characterisation of linezolid resistance in two vancomycin-resistant (VanB) Enterococcus faecium isolates using Pyrosequencing.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecium; Female; Genes, Bacterial; Genes, rRNA; Gram-Positive Bacterial Infections; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Linezolid; Microbial Sensitivity Tests; Mucositis; Oxazolidinones; Pancreatitis, Acute Necrotizing; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Vancomycin; Vancomycin Resistance | 2008 |
In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A.
Topics: Acetamides; Anti-Bacterial Agents; Cinnamates; Dioxoles; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Hygromycin B; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones | 2008 |
A singular case of granulomatous lesions of unknown significance.
Topics: Acetamides; Anti-Infective Agents; Female; Granuloma; Humans; Linezolid; Liver Diseases; Middle Aged; Oxazolidinones; Skin Ulcer; Splenic Diseases; Staphylococcal Infections | 2008 |
Regioselective and stereospecific synthesis of enantiopure 1,3-oxazolidin-2-ones by intramolecular ring opening of 2-(Boc-aminomethyl)aziridines. Preparation of the antibiotic linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Aziridines; Linezolid; Molecular Conformation; Oxazolidinones; Stereoisomerism | 2008 |
Cost-effectiveness of linezolid versus vancomycin for hospitalised patients with complicated skin and soft-tissue infections in Germany.
Topics: Acetamides; Anti-Bacterial Agents; Cost-Benefit Analysis; Decision Support Techniques; Delphi Technique; Germany; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Soft Tissue Infections; Staphylococcal Skin Infections; Vancomycin | 2009 |
NMR and molecular modeling study, as complementary techniques to capillary electrophoresis method to elucidate the separation mechanism of linezolid enantiomers.
Topics: Acetamides; Anti-Infective Agents; Indicators and Reagents; Linezolid; Magnetic Resonance Spectroscopy; Models, Molecular; Oxazolidinones; Stereoisomerism | 2008 |
Efficacy and pharmacodynamics of linezolid, alone and in combination with rifampicin, in an experimental model of methicillin-resistant Staphylococcus aureus endocarditis.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Drug Therapy, Combination; Endocarditis, Bacterial; Heart Valves; Kidney; Linezolid; Liver; Lung; Male; Methicillin Resistance; Microbial Sensitivity Tests; Microbial Viability; Models, Animal; Oxazolidinones; Plasma; Rabbits; Rifampin; Spleen; Staphylococcal Infections; Staphylococcus aureus; Survival Analysis; Vancomycin | 2008 |
Antibiotic-induced serotonin syndrome.
Topics: Acetamides; Adult; Anti-Infective Agents; Empyema; Female; Humans; Linezolid; Methicillin Resistance; Oxazolidinones; Serotonin Syndrome; Staphylococcal Infections | 2011 |
Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis.
Topics: Acetamides; Anthrax; Anti-Bacterial Agents; Bacillus anthracis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Bacterial; Humans; In Vitro Techniques; Linezolid; Models, Biological; Monte Carlo Method; Mutation; Oxazolidinones | 2008 |
[Some new antitubercular agents].
Topics: Acetamides; Antitubercular Agents; Diarylquinolines; Humans; Linezolid; Nitroimidazoles; Oxazoles; Oxazolidinones; Quinolines | 2008 |
Effect of sub-MIC concentrations of metronidazole, vancomycin, clindamycin and linezolid on toxin gene transcription and production in Clostridium difficile.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Clindamycin; Clostridioides difficile; Enterotoxins; Gene Expression Regulation, Bacterial; Humans; Linezolid; Metronidazole; Microbial Sensitivity Tests; Oxazolidinones; Polymerase Chain Reaction; Time Factors; Transcription, Genetic; Vancomycin | 2008 |
Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit.
Topics: Acetamides; Anti-Bacterial Agents; Crystallization; Haloarcula marismortui; Linezolid; Models, Molecular; Molecular Structure; Oxazolidinones; Protein Binding; Protein Conformation; Ribosome Subunits, Large, Archaeal | 2008 |
In vitro activities of linezolid and tigecycline against methicillin-resistant Staphylococcus aureus strains.
Topics: Acetamides; Anti-Infective Agents; Cross Infection; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Tigecycline; Turkey | 2008 |
Linezolid-induced lingua villosa nigra.
Topics: Acetamides; Aged; Anti-Infective Agents; Color; Humans; Linezolid; Male; Oxazolidinones; Tongue Diseases | 2008 |
Methicillin-resistant Staphylococcus aureus endocarditis in an extremely low-birth-weight infant treated with linezolid.
Topics: Acetamides; Anti-Infective Agents; Endocarditis, Bacterial; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Infant, Premature, Diseases; Linezolid; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2008 |
Activities of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated and hospital-associated methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Community-Acquired Infections; Cross Infection; Daptomycin; Drug Synergism; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2008 |
Noncardiogenic pulmonary edema in a patient receiving vancomycin and oxycodone-acetaminophen.
Topics: Acetamides; Acetaminophen; Analgesics; Anti-Infective Agents; Cellulitis; Diphenhydramine; Drug Combinations; Famotidine; Furosemide; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Oxycodone; Pulmonary Edema; Staphylococcal Skin Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin | 2008 |
Safety of linezolid in patients with baseline thrombocytopenia.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Thrombocytopenia | 2008 |
Empiric antibiotic therapy for acute osteoarticular infections with suspected methicillin-resistant Staphylococcus aureus or Kingella.
Topics: Acetamides; Acute Disease; Anti-Bacterial Agents; Arthritis, Infectious; Child, Preschool; Decision Trees; Humans; Infant; Kingella; Linezolid; Methicillin Resistance; Neisseriaceae Infections; Osteomyelitis; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2008 |
Linezolid-associated small-fiber neuropathy.
Topics: Acetamides; Anti-Infective Agents; Female; Humans; Linezolid; Middle Aged; Nerve Fibers; Oxazolidinones; Peripheral Nervous System Diseases | 2008 |
Safety and efficacy of long-term treatment with linezolid in cystic fibrosis: case report.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Cystic Fibrosis; Humans; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2008 |
Short-term success, but long-term treatment failure with linezolid for enterococcal endocarditis.
Topics: Acetamides; Aged; Anti-Infective Agents; Endocarditis, Bacterial; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Oxazolidinones; Treatment Failure | 2008 |
[Linezolid therapy for the treatment of nocardial infection: report of a case and review of the literature].
Topics: Acetamides; Adolescent; Adult; Anti-Infective Agents; Child; Female; Humans; Linezolid; Male; Middle Aged; Nocardia Infections; Oxazolidinones; Time Factors; Treatment Outcome | 2008 |
Effect of linezolid against postneurosurgical meningitis caused by methicillin-resistant Staphylococcus epidermidis: case report.
Topics: Acetamides; Aged; Anti-Infective Agents; Humans; Linezolid; Male; Meningeal Neoplasms; Meningioma; Meningitis, Bacterial; Methicillin Resistance; Neurosurgical Procedures; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Treatment Outcome | 2008 |
Pharmacokinetics of repeated dosing of linezolid in a hemodialysis patient with chronic renal failure.
Topics: Acetamides; Anti-Infective Agents; Humans; Kidney Failure, Chronic; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Renal Dialysis; Staphylococcal Infections; Staphylococcus aureus | 2008 |
Case series report of a linezolid-containing regimen for extensively drug-resistant tuberculosis.
Topics: Acetamides; Adult; Anti-Infective Agents; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2008 |
Successful long-term treatment with linezolid for disseminated infection with multiresistant Nocardia farcinica.
Topics: Acetamides; Adult; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Humans; Immunocompromised Host; Linezolid; Male; Microbial Sensitivity Tests; Nocardia; Nocardia Infections; Oxazolidinones; Pleural Effusion; Time Factors; Treatment Outcome | 2008 |
Early linezolid-associated lactic acidosis in a patient treated for tuberculous spondylodiscitis.
Topics: Acetamides; Acidosis, Lactic; Aged, 80 and over; Anti-Infective Agents; Discitis; Female; Humans; Linezolid; Lumbar Vertebrae; Mycobacterium tuberculosis; Oxazolidinones; Treatment Outcome; Tuberculosis | 2008 |
Assessment by time-kill methodology of the synergistic effects of oritavancin in combination with other antimicrobial agents against Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Drug Synergism; Fluoroquinolones; Gentamicins; Glycopeptides; Humans; Linezolid; Lipoglycopeptides; Methicillin Resistance; Microbial Sensitivity Tests; Moxifloxacin; Oxazolidinones; Polysorbates; Quinolines; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Surface-Active Agents; Vancomycin Resistance | 2008 |
Development of an integrated semi-automated system for in vitro pharmacodynamic modelling.
Topics: Acetamides; Anti-Bacterial Agents; Automation; Colony Count, Microbial; Humans; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Microbial Viability; Oxazolidinones; Staphylococcus aureus; Time Factors | 2008 |
Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intravenous linezolid in an allogeneic cord blood stem cell transplant recipient.
Topics: Acetamides; Anti-Bacterial Agents; Cord Blood Stem Cell Transplantation; Female; Humans; Injections, Intravenous; Linezolid; Meningoencephalitis; Methicillin Resistance; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2008 |
In vitro activity of ceftobiprole, linezolid, tigecycline, and 23 other antimicrobial agents against Staphylococcus aureus isolates in China.
Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; China; Humans; Linezolid; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Prevalence; Staphylococcal Infections; Staphylococcus aureus; Tigecycline | 2008 |
Pharmacokinetics and penetration of linezolid into inflamed soft tissue in diabetic foot infections.
Topics: Acetamides; Aged; Anti-Infective Agents; Diabetic Foot; Female; Humans; Inflammation; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Permeability; Soft Tissue Infections; Staphylococcal Skin Infections | 2008 |
R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance.
Topics: Acetamides; Anti-Bacterial Agents; Binding Sites; Binding, Competitive; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Protein Biosynthesis; Ribosomes; RNA, Bacterial; RNA, Ribosomal, 23S; Staphylococcus aureus | 2008 |
Effect of oxazolidinone, RBx 7644 (ranbezolid), on inhibition of staphylococcal adherence to plastic surfaces.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Dose-Response Relationship, Drug; Furans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Plastics; Staphylococcus aureus; Staphylococcus epidermidis; Time Factors; Vancomycin; Virginiamycin | 2008 |
Linezolid activity against disseminated Listeria monocytogenes meningitis and central nervous system abscesses: focus on early drug myelotoxicity.
Topics: Acetamides; Anemia; Anti-Infective Agents; Brain Abscess; Brain Stem; Cerebellar Diseases; Humans; Immunocompetence; Linezolid; Magnetic Resonance Imaging; Male; Meningitis, Listeria; Meropenem; Middle Aged; Oxazolidinones; Thienamycins; Tomography, X-Ray Computed | 2007 |
Glycopeptide insensitive Staphylococcus aureus subdural empyema treated with linezolid and rifampicin.
Topics: Acetamides; Anti-Infective Agents; Child, Preschool; Drainage; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Empyema, Subdural; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Rifampin; Staphylococcal Infections; Teicoplanin | 2008 |
Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Community-Acquired Infections; Cross Infection; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance | 2008 |
Efficacy of linezolid alone and in combination with rifampin in staphylococcal experimental foreign-body infection.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Drug Resistance, Bacterial; Drug Therapy, Combination; Foreign Bodies; Linezolid; Male; Microbial Sensitivity Tests; Microbial Viability; Oxazolidinones; Rats; Rifampin; Soft Tissue Infections; Staphylococcal Infections; Treatment Outcome | 2008 |
Linezolid for treatment of catheter-related cerebrospinal fluid infections in preterm infants.
Topics: Acetamides; Anti-Infective Agents; Bacterial Infections; Cerebrospinal Fluid; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Linezolid; Oxazolidinones; Ventriculostomy | 2008 |
Reduction in rates of methicillin-resistant Staphylococcus aureus infection after introduction of quarterly linezolid-vancomycin cycling in a surgical intensive care unit.
Topics: Acetamides; Anti-Bacterial Agents; Drug Administration Schedule; Enterococcus; General Surgery; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Linezolid; Methicillin Resistance; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin | 2008 |
Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Enterococcus faecalis; Gram-Negative Bacteria; Gram-Positive Bacteria; Haemophilus influenzae; Indoles; Linezolid; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Staphylococcus aureus; Structure-Activity Relationship; Vancomycin Resistance | 2008 |
Lack of increase in time to blood culture positivity in a patient with persistent methicillin-resistant Staphylococcus aureus bacteremia predicts failure of antimicrobial therapy.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacteremia; Blood; Catheters, Indwelling; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Time Factors; Treatment Failure; Vancomycin | 2008 |
Daily half-dose linezolid for the treatment of intractable multidrug-resistant tuberculosis.
Topics: Acetamides; Adult; Anti-Infective Agents; Culture Media; Drug Administration Schedule; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuberculosis; Female; Humans; Korea; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Sputum; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Young Adult | 2009 |
Renal function as a predictor of linezolid-induced thrombocytopenia.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Blood Urea Nitrogen; Creatinine; Female; Humans; Kidney Function Tests; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Predictive Value of Tests; Staphylococcal Infections; Thrombocytopenia; Treatment Outcome | 2009 |
Successful treatment of vancomycin-resistant enterococcal ventriculitis in a pediatric patient with linezolid.
Topics: Acetamides; Aged; Anti-Infective Agents; Bacterial Infections; Brain Diseases; Cerebral Ventricles; Enterococcus; Female; Humans; Infant; Linezolid; Male; Middle Aged; Oxazolidinones; Vancomycin Resistance | 2008 |
A case of Erysipelothrix rhusiopathiae causing bilateral endogenous endophthalmitis.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Drug Therapy, Combination; Endophthalmitis; Erysipelothrix Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Penicillin G; Sus scrofa; Zoonoses | 2008 |
In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.
Topics: Acetamides; Anti-Bacterial Agents; Binding Sites; Drug Resistance, Bacterial; Enterococcus; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Models, Molecular; Oxazolidinones; Prodrugs; Staphylococcus aureus | 2008 |
Bacteriostatic or bactericidal effect of linezolid against multiresistant Streptococcus pneumoniae.
Topics: Acetamides; Anti-Bacterial Agents; Child, Preschool; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Penicillin Resistance; Phylogeny; Polymerase Chain Reaction; Streptococcus pneumoniae; Vancomycin | 2008 |
Toxicity of extended courses of linezolid: results of an Infectious Diseases Society of America Emerging Infections Network survey.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Infections; Communicable Diseases, Emerging; Data Collection; Drug Administration Schedule; Humans; Linezolid; Oxazolidinones; Practice Patterns, Physicians'; Societies, Medical; United States | 2008 |
In vitro activity of linezolid against multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR)-TB isolates.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis, Multidrug-Resistant; Young Adult | 2009 |
Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Crystallography, X-Ray; Drug Design; Gram-Negative Bacteria; Gram-Positive Bacteria; Haemophilus influenzae; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Moraxella catarrhalis; Oxazolidinones; Sparsomycin; Structure-Activity Relationship | 2008 |
Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Crystallography, X-Ray; Drug Design; Escherichia coli; Haemophilus influenzae; Linezolid; Microbial Sensitivity Tests; Molecular Conformation; Molecular Structure; Moraxella catarrhalis; Oxazolidinones; Protein Biosynthesis; Sparsomycin; Structure-Activity Relationship | 2008 |
Comparison of the therapeutic efficacy of linezolid and vancomycin and correlation of serum and tissue malondialdehyde and myeloperoxidase in an experimental mediastinitis model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Linezolid; Male; Malondialdehyde; Mediastinitis; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Peroxidase; Rats; Rats, Wistar; Vancomycin | 2009 |
Biliary penetration and pharmacodynamic exposure of linezolid in liver transplant patients.
Topics: Acetamides; Anti-Bacterial Agents; Bile Ducts; Cholangitis; Chromatography, High Pressure Liquid; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Liver Transplantation; Male; Middle Aged; Oxazolidinones; Plasma; Vancomycin Resistance | 2009 |
Multidrug- and extensively drug-resistant tuberculosis, Germany.
Topics: Acetamides; Adult; Antitubercular Agents; Cohort Studies; Drug Resistance, Multiple, Bacterial; Emigrants and Immigrants; Extensively Drug-Resistant Tuberculosis; Female; Germany; Humans; Linezolid; Male; Mycobacterium tuberculosis; Oxazolidinones; Retrospective Studies; Risk Factors; Sentinel Surveillance; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2008 |
Pyrazoline-based mycobactin analogues as MAO-inhibitors.
Topics: Acetamides; Animals; Binding Sites; Catalytic Domain; Drug Design; Humans; Inhibitory Concentration 50; Linezolid; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Pyrazoles; Rats; Siderophores | 2008 |
Arrest of endogenous ocular nocardiosis under linezolid therapy.
Topics: Acetamides; Anti-Infective Agents; Coloring Agents; Eye Infections, Bacterial; Female; Fluorescein Angiography; Humans; Indocyanine Green; Kidney Transplantation; Linezolid; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging; Meningitis, Bacterial; Middle Aged; Nocardia; Nocardia Infections; Oxazolidinones; Reoperation; Retinal Diseases; Tomography, Optical Coherence; Visual Acuity | 2010 |
Endemic linezolid-resistant Staphylococcus epidermidis in a critical care unit.
Topics: Acetamides; Anti-Bacterial Agents; Cluster Analysis; Critical Illness; Cross Infection; DNA Fingerprinting; DNA, Bacterial; Drug Resistance, Bacterial; Drug Utilization; Female; Genotype; Humans; Intensive Care Units; Linezolid; Male; Microbial Sensitivity Tests; Molecular Epidemiology; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus epidermidis | 2009 |
An organocatalytic approach to the construction of chiral oxazolidinone rings and application in the synthesis of antibiotic linezolid and its analogues.
Topics: Acetamides; Anti-Bacterial Agents; Catalysis; Linezolid; Oxazolidinones; Stereoisomerism | 2008 |
Enantiomeric separation of Linezolid by chiral reversed-phase liquid chromatography.
Topics: Acetamides; Chromatography, Liquid; Linezolid; Oxazolidinones; Stereoisomerism | 2008 |
Colonisation with vancomycin- and linezolid-resistant Enterococcus faecium in a university hospital: molecular epidemiology and risk factor analysis.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Bacterial Agents; Carrier State; DNA Fingerprinting; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecium; Environmental Microbiology; Feces; Female; Genotype; Gram-Positive Bacterial Infections; Greece; Hospitals, University; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Epidemiology; Oxazolidinones; Point Mutation; Polymorphism, Restriction Fragment Length; Risk Factors; RNA, Bacterial; RNA, Ribosomal, 23S; Vancomycin Resistance | 2009 |
[Different manifestations of the cerebral nocardiosis].
Topics: Acetamides; Aged; Aphasia; Bacteremia; Brain Abscess; Drainage; Headache; Humans; Linezolid; Magnetic Resonance Imaging; Male; Microbial Sensitivity Tests; Middle Aged; Neuropsychological Tests; Nocardia Infections; Opportunistic Infections; Oxazolidinones; Tomography, X-Ray Computed | 2008 |
United States resistance surveillance results for linezolid (LEADER Program for 2007).
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Drug Resistance, Bacterial; Humans; Linezolid; Oxazolidinones; Product Surveillance, Postmarketing; United States | 2008 |
[A hope for multidrug-resistant tuberculosis?].
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2008 |
[Sideroblastic anemia after prolonged linezolid therapy].
Topics: Abscess; Acetamides; Aged; Anemia, Sideroblastic; Anti-Infective Agents; Humans; Laryngeal Neoplasms; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections | 2008 |
Linezolid for the treatment of drug-resistant infections.
Topics: Acetamides; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Resistance, Multiple, Bacterial; Economics, Pharmaceutical; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2008 |
Efficacy of telavancin in the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis: studies with a rabbit model.
Topics: Acetamides; Aminoglycosides; Animals; Anti-Bacterial Agents; Bone Marrow; Colony Count, Microbial; Linezolid; Lipoglycopeptides; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Osteomyelitis; Oxazolidinones; Rabbits; Random Allocation; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2009 |
Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
Topics: Acetamides; Anti-Bacterial Agents; Cell Membrane Permeability; Furans; Linezolid; Oxazoles; Oxazolidinones; Protein Biosynthesis; Protein Synthesis Inhibitors; Ribosomes; Staphylococcus aureus; Staphylococcus epidermidis; Transcription, Genetic | 2009 |
Promising antituberculosis activity of the oxazolidinone PNU-100480 relative to that of linezolid in a murine model.
Topics: Acetamides; Animals; Antitubercular Agents; Colony Count, Microbial; Disease Models, Animal; Drug Therapy, Combination; Female; Linezolid; Lung; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis | 2009 |
Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Dose-Response Relationship, Drug; Drug Therapy, Combination; Foreign-Body Reaction; Guinea Pigs; Injections, Intraperitoneal; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Models, Animal; Oxazolidinones; Plankton; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Time Factors | 2009 |
Simultaneous quantification of linezolid, rifampicin, levofloxacin, and moxifloxacin in human plasma using high-performance liquid chromatography with UV.
Topics: Acetamides; Anti-Bacterial Agents; Antibiotics, Antitubercular; Aza Compounds; Calibration; Chromatography, High Pressure Liquid; Fluoroquinolones; Humans; Levofloxacin; Linezolid; Moxifloxacin; Ofloxacin; Oxazolidinones; Quality Control; Quinolines; Reference Standards; Reproducibility of Results; Rifampin; Solutions; Solvents; Spectrophotometry, Ultraviolet | 2009 |
Linezolid pharmacodynamics with Staphylococcus aureus in an in vitro dynamic model.
Topics: Acetamides; Anti-Infective Agents; Area Under Curve; Colony Count, Microbial; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Microbial Viability; Models, Theoretical; Oxazolidinones; Staphylococcus aureus; Time Factors; Vancomycin Resistance | 2009 |
Pharmacokinetics and tolerance of linezolid for meticillin-resistant Staphylococcus aureus mediastinitis in paediatric patients.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Child, Preschool; Cross Infection; Female; Humans; Infant; Injections, Intravenous; Linezolid; Male; Mediastinitis; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Plasma; Staphylococcal Infections; Surgical Wound Infection | 2009 |
[Successful treatment of infectious endocarditis with linezolid: a case report (no abstract)].
Topics: Acetamides; Aged; Anti-Infective Agents; Endocarditis, Subacute Bacterial; Humans; Linezolid; Male; Oxazolidinones; Treatment Outcome | 2008 |
Pharmacokinetics of linezolid in human non-inflamed vitreous after systemic administration.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Humans; Infusions, Intravenous; Linezolid; Male; Middle Aged; Oxazolidinones; Serum; Time Factors; Vitreous Body | 2009 |
Linezolid-resistant Staphylococcus cohnii, Greece.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Drug Resistance, Bacterial; Female; Greece; Humans; Intensive Care Units; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus | 2009 |
Peripheral neuropathy in an adolescent treated with linezolid.
Topics: Acetamides; Amines; Analgesics; Anti-Bacterial Agents; Child; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Linezolid; Osteomyelitis; Oxazolidinones; Peripheral Nervous System Diseases | 2009 |
Treatment of extensively drug-resistant tuberculosis.
Topics: Acetamides; Anti-Infective Agents; Antitubercular Agents; Aza Compounds; Dose-Response Relationship, Drug; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Fluoroquinolones; Humans; Linezolid; Moxifloxacin; Oxazolidinones; Quinolines | 2009 |
Failure of linezolid therapy for post-neurosurgical meningitis due to Enterococcus faecium.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecium; Female; Humans; Linezolid; Meningitis, Bacterial; Microbial Sensitivity Tests; Oxazolidinones; Treatment Failure | 2009 |
Early development of lactic acidosis with short term linezolid treatment in a renal recipient.
Topics: Acetamides; Acidosis, Lactic; Anti-Infective Agents; Citrobacter freundii; Enterobacteriaceae Infections; Female; Humans; Immunocompromised Host; Kidney Transplantation; Linezolid; Meropenem; Middle Aged; Oxazolidinones; Thienamycins; Urinary Tract Infections | 2008 |
Auditory nerve neuropathy in a neonate after linezolid treatment.
Topics: Acetamides; Anti-Bacterial Agents; Cochlear Nerve; Hearing Loss, Bilateral; Humans; Infant, Newborn; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections | 2009 |
Pharmacokinetics and pharmacodynamics of linezolid in children with cystic fibrosis.
Topics: Acetamides; Adolescent; Anti-Infective Agents; Child; Child, Preschool; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Retrospective Studies | 2009 |
Effect of linezolid compared with glycopeptides in methicillin-resistant Staphylococcus aureus severe pneumonia in piglets.
Topics: Acetamides; Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Glycopeptides; Immunohistochemistry; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Probability; Random Allocation; Respiration, Artificial; Sensitivity and Specificity; Severity of Illness Index; Survival Rate; Swine; Treatment Outcome | 2009 |
[A case of vancomycin resistant Leuconostoc meningitis].
Topics: Acetamides; Anti-Infective Agents; Female; Gram-Positive Bacterial Infections; Humans; Leuconostoc; Linezolid; Meningitis, Bacterial; Middle Aged; Oxazolidinones; Spinal Puncture; Subarachnoid Hemorrhage; Vancomycin Resistance | 2008 |
In vitro activities of daptomycin, tigecycline, linezolid and eight other antibiotics, alone and in combination, against 41 Staphylococcus spp. clinical isolates from bone and joint infections.
Topics: Acetamides; Anti-Bacterial Agents; Arthritis, Infectious; Bone and Bones; Daptomycin; Drug Synergism; Humans; Joints; Linezolid; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Staphylococcal Infections; Staphylococcus; Tigecycline | 2009 |
Pharmacokinetic evaluation of linezolid in patients with major thermal injuries.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Area Under Curve; Burns; Chromatography, High Pressure Liquid; Female; Humans; Infusions, Intravenous; Linezolid; Male; Metabolic Clearance Rate; Middle Aged; Oxazolidinones; Plasma; Time Factors; Urine; Young Adult | 2009 |
Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Point Mutation; RNA, Bacterial; RNA, Ribosomal, 23S; Staphylococcus | 2009 |
Linezolid inducing complex partial status epilepticus in a patient with epilepsy.
Topics: Acetamides; Anti-Bacterial Agents; Epilepsy; Female; Humans; Linezolid; Middle Aged; Oxazolidinones; Status Epilepticus; Wound Healing | 2009 |
Hyperbaric oxygen as adjunctive therapy in experimental mediastinitis.
Topics: Acetamides; Animals; Anti-Infective Agents; Combined Modality Therapy; Hyperbaric Oxygenation; Linezolid; Male; Mediastinitis; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Rats; Rats, Wistar; Staphylococcal Infections; Teicoplanin; Vancomycin | 2009 |
[Conservative treatment of a hip prosthesis infection due to methicillin-resistant Staphylococcus aureus using prolonged antibiotic therapy based on linezolid followed by daptomycin].
Topics: Acetamides; Aged, 80 and over; Anesthesia; Anti-Bacterial Agents; Bacteremia; Bone Marrow Diseases; Comorbidity; Contraindications; Daptomycin; Drug Administration Schedule; Drug Therapy, Combination; Gentamicins; Hip Prosthesis; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Prosthesis-Related Infections; Rifampin; Staphylococcal Infections; Systemic Inflammatory Response Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination | 2008 |
How should we treat "difficult" multidrug-resistant tuberculosis?
Topics: Acetamides; Adult; Anti-Infective Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Linezolid; Male; Maximum Tolerated Dose; Oxazolidinones; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2009 |
[Serotonin syndrome associated with linezolid].
Topics: Acetamides; Aged; Anti-Infective Agents; Female; Humans; Linezolid; Oxazolidinones; Serotonin Syndrome | 2009 |
Serotonin toxicity as a consequence of linezolid use in revision hip arthroplasty.
Topics: Acetamides; Administration, Oral; Analgesics; Anti-Infective Agents; Arthroplasty, Replacement, Hip; Contraindications; Cyclohexanols; Drug Interactions; Female; Humans; Linezolid; Middle Aged; Oxazolidinones; Postoperative Complications; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Syndrome; Venlafaxine Hydrochloride | 2008 |
A case of optic neuropathy after short-term linezolid use in a patient with acute lymphocytic leukemia.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Female; Humans; Linezolid; Optic Nerve Diseases; Oxazolidinones; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sepsis; Young Adult | 2009 |
Nosocomial spread of linezolid-resistant Staphylococcus haemolyticus infections in an intensive care unit.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Bacteremia; Catheterization; Cluster Analysis; Cross Infection; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Female; Humans; Intensive Care Units; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus haemolyticus; Teicoplanin | 2009 |
Characterisation of a Staphylococcus aureus strain with progressive loss of susceptibility to vancomycin and daptomycin during therapy.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Daptomycin; Drug Resistance, Bacterial; Endocarditis, Bacterial; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin; Virginiamycin | 2009 |
Teeth and tongue discoloration during linezolid therapy.
Topics: Acetamides; Anti-Infective Agents; Arthritis; Bacteremia; Child; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Tongue; Tooth Discoloration | 2009 |
In vitro analysis of resistance selection by linezolid in vancomycin-susceptible and -resistant Enterococcus faecalis and Enterococcus faecium.
Topics: Acetamides; Anti-Bacterial Agents; Colony Count, Microbial; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Humans; Linezolid; Microbial Sensitivity Tests; Models, Theoretical; Oxazolidinones; Selection, Genetic; Vancomycin Resistance | 2009 |
In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Oxazolidinones; Pneumococcal Infections; Staphylococcal Infections; Staphylococcal Skin Infections; Staphylococcus aureus; Streptococcus pneumoniae; Treatment Outcome; Vancomycin | 2009 |
Cost-effectiveness of linezolid vs vancomycin in suspected methicillin-resistant Staphylococcus aureus nosocomial pneumonia in Germany.
Topics: Acetamides; Anti-Bacterial Agents; Cost-Benefit Analysis; Cross Infection; Decision Support Techniques; Drug Costs; Female; Germany; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Models, Economic; Oxazolidinones; Pneumonia, Staphylococcal; Retrospective Studies; Vancomycin | 2009 |
A retrospective TBNET assessment of linezolid safety, tolerability and efficacy in multidrug-resistant tuberculosis.
Topics: Acetamides; Anti-Infective Agents; Antitubercular Agents; Cohort Studies; Drug Resistance, Bacterial; Europe; Female; Humans; Linezolid; Male; Odds Ratio; Oxazolidinones; Regression Analysis; Retrospective Studies; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2009 |
Clinical evaluation after a notification policy of linezolid use: a case series of 22 patients.
Topics: Acetamides; Aged; Anti-Infective Agents; Cross Infection; Drug and Narcotic Control; Female; Humans; Infection Control; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Staphylococcal Infections | 2009 |
[Successful treatment of life-threatening Panton-Valentine leucocidin positive Staphylococcus aureus pneumonia with antibiotics and immunoglobulins targeting the toxin production].
Topics: Acetamides; Adult; Anti-Infective Agents; Bacterial Toxins; Clindamycin; Exotoxins; Humans; Immunoglobulins, Intravenous; Leukocidins; Linezolid; Male; Multiple Organ Failure; Oxazolidinones; Pneumonia, Bacterial; Respiratory Distress Syndrome; Staphylococcal Infections | 2009 |
Cost-effectiveness of linezolid versus vancomycin for hospitalized patients with complicated skin and soft-tissue infections in France.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Decision Trees; Drug Monitoring; France; Gram-Positive Bacterial Infections; Humans; Inpatients; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Skin Diseases, Infectious; Soft Tissue Infections; Staphylococcal Infections; Staphylococcal Skin Infections | 2009 |
[In vitro activity of linezolid/ertapenem combination in resistant gram-positive bacteria].
Topics: Acetamides; Anti-Infective Agents; beta-Lactams; Drug Combinations; Drug Synergism; Enterococcus faecium; Ertapenem; Gram-Positive Cocci; Humans; Linezolid; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus epidermidis; Vancomycin Resistance | 2009 |
[A case of meningitis emerged as a complication of hidradenitis suppurativa].
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Buttocks; Ceftriaxone; Cerebrospinal Fluid; Gram-Positive Cocci; Hidradenitis Suppurativa; Humans; Linezolid; Male; Meningitis, Bacterial; Middle Aged; Oxazolidinones | 2009 |
Anti-MRSA activity of aldehyde Schiff base N-aryl thiosemicarbazones.
Topics: Acetamides; Aldehydes; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Schiff Bases; Staphylococcal Infections; Thiosemicarbazones; Vancomycin | 2009 |
Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance.
Topics: Acetamides; Anti-Infective Agents; Bacterial Proteins; Base Sequence; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Genome, Bacterial; Linezolid; Molecular Sequence Data; Mutation; Oxazolidinones; Phylogeny; RNA, Ribosomal, 23S; Sequence Homology, Nucleic Acid; Streptococcus pneumoniae; tRNA Methyltransferases | 2009 |
[Linezolid as treatment of Nocardia asteroides infection].
Topics: Acetamides; Aged; Anti-Infective Agents; Humans; Linezolid; Lung Diseases; Male; Nocardia asteroides; Nocardia Infections; Oxazolidinones | 2010 |
[Case report: severe thrombocytopenia].
Topics: Acetamides; Aged; Anti-Infective Agents; Humans; Linezolid; Male; Oxazolidinones; Pneumonia, Staphylococcal; Thrombocytopenia | 2009 |
Disseminated Nocardia infection with subretinal abscess.
Topics: Abscess; Acetamides; Adult; Anti-Infective Agents; Ciprofloxacin; Diagnosis, Differential; Female; Humans; Immunocompromised Host; Linezolid; Nocardia; Nocardia Infections; Oxazolidinones; Retinal Diseases; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination | 2010 |
Linezolid resistance in Staphylococcus epidermidis associated with a G2603T mutation in the 23S rRNA gene.
Topics: Acetamides; Amino Acid Substitution; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Linezolid; Oxazolidinones; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus epidermidis | 2009 |
Linezolid-induced complex partial seizures in a patient with epilepsy.
Topics: Acetamides; Aged; Anti-Infective Agents; Epilepsy; Epilepsy, Complex Partial; Humans; Levetiracetam; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Piracetam; Staphylococcal Infections; Ulcer | 2009 |
Impact of prolonged treatment with linezolid on the human gut flora.
Topics: Acetamides; Aged; Candida; Gram-Negative Bacteria; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Intestinal Mucosa; Knee Prosthesis; Linezolid; Male; Osteomyelitis; Oxazolidinones; Prosthesis-Related Infections; Treatment Outcome | 2009 |
Drugs for MRSA with reduced susceptibility to vancomycin.
Topics: Acetamides; Anti-Infective Agents; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Vancomycin Resistance | 2009 |
Trends in antibacterial use in hospitalized pediatric patients in United States academic health centers.
Topics: Academic Medical Centers; Acetamides; Adolescent; Aminoglycosides; Anti-Bacterial Agents; Child; Child, Preschool; Drug Utilization; Hospitalization; Humans; Infant; Infant, Newborn; Linezolid; Macrolides; Oxazolidinones; Pediatrics; United States | 2009 |
Efficacy and tolerability of linezolid in chronic osteomyelitis and prosthetic joint infections: a case-control study.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Case-Control Studies; Chronic Disease; Enterococcus; Female; Humans; Joint Prosthesis; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Osteomyelitis; Oxazolidinones; Prosthesis-Related Infections; Retrospective Studies; Staphylococcal Infections | 2009 |
Vancomycin-resistant enterococcal bacteraemia: is daptomycin as effective as linezolid?
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Daptomycin; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Treatment Outcome; Vancomycin Resistance; Young Adult | 2009 |
A T2504A mutation in the 23S rRNA gene responsible for high-level resistance to linezolid of Staphylococcus epidermidis.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Humans; Linezolid; Oxazolidinones; Point Mutation; RNA, Bacterial; RNA, Ribosomal, 23S; Staphylococcus epidermidis | 2009 |
Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Vancomycin | 2009 |
Drug use density in critically ill children and newborns: analysis of various methodologies.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Critical Illness; Drug Administration Schedule; Drug Utilization Review; Humans; Infant; Intensive Care Units, Pediatric; Intensive Care, Neonatal; Linezolid; Oxazolidinones; Retrospective Studies; Vancomycin | 2009 |
Bacteremia caused by an Enterococcus faecalis isolate with high-level linezolid resistance in a teenager with Crohn's disease.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Bacteremia; Crohn Disease; Drug Resistance, Bacterial; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Treatment Outcome; Vancomycin | 2009 |
A novel antibiotic, linezolid, reduces intraperitoneal adhesion formation in the rat uterine horn model.
Topics: Acetamides; Administration, Oral; Animals; Anti-Infective Agents; Dose-Response Relationship, Drug; Female; Linezolid; Oxazolidinones; Prospective Studies; Random Allocation; Rats; Rats, Wistar; Statistics, Nonparametric; Tissue Adhesions; Uterus | 2009 |
Appearance of ring sideroblasts in bone marrow during linezolid therapy.
Topics: Acetamides; Anti-Infective Agents; Biopsy, Needle; Blood Platelets; Bone Marrow; Erythroblasts; Erythropoiesis; Female; Humans; Linezolid; Middle Aged; Oxazolidinones; Platelet Count | 2009 |
[Role of linezolid in the treatment of endocarditis].
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Endocarditis, Bacterial; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies | 2009 |
Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis.
Topics: Acetamides; Adult; Antitubercular Agents; Female; Humans; Linezolid; Male; Oxazolidinones; Sputum; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2009 |
New treatment options and protocols for peritoneal dialysis-related peritonitis.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Humans; Linezolid; Oxazolidinones; Peritoneal Dialysis; Peritonitis; Staphylococcal Infections; Staphylococcus aureus; Virginiamycin | 2009 |
Successful salvage therapy with daptomycin after linezolid and vancomycin failure in a liver transplant recipient with methicillin-resistant Staphylococcus aureus endocarditis.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Cross Infection; Daptomycin; Endocarditis, Bacterial; Humans; Linezolid; Liver Transplantation; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Salvage Therapy; Staphylococcal Infections; Treatment Failure; Treatment Outcome; Vancomycin | 2009 |
Elevated creatine phosphokinase levels associated with linezolid therapy.
Topics: Acetamides; Aged; Anti-Infective Agents; Creatine Kinase; Humans; Hypolipidemic Agents; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal | 2009 |
Recurrent cellulitis in a case of Aagenaes syndrome.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cellulitis; Cholestasis, Intrahepatic; Humans; Ketorolac; Linezolid; Lower Extremity; Lymphedema; Male; Oxazolidinones; Recurrence; Syndrome; Vancomycin | 2009 |
ZAAPS International Surveillance Program (2007) for linezolid resistance: results from 5591 Gram-positive clinical isolates in 23 countries.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Asia; Australia; Canada; Drug Resistance, Bacterial; Europe; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Latin America; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2009 |
Linezolid-induced purpuric medication reaction.
Topics: Acetamides; Anti-Infective Agents; Biopsy; Drug Eruptions; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Purpura; Skin | 2009 |
Addition of PNU-100480 to first-line drugs shortens the time needed to cure murine tuberculosis.
Topics: Acetamides; Animals; Antitubercular Agents; Colony-Forming Units Assay; Disease Models, Animal; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female; Linezolid; Lung; Mice; Mice, Inbred BALB C; Oxazolidinones; Time Factors; Treatment Outcome; Tuberculosis, Pulmonary | 2009 |
Colonization of the tip of a thoracic catheter by Enterococcus faecalis resistant to vancomycin and linezolid.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Catheterization; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Vancomycin | 2009 |
Noninferiority of linezolid for skin and bloodstream infections.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Biomedical Research; Catheterization; Humans; Linezolid; Oxazolidinones; Research Design; Skin Diseases, Bacterial | 2009 |
Concerns about "Complicated skin and skin-structure infections and catheter-related bloodstream infections: noninferiority of linezolid in a phase 3 study".
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Catheterization; Humans; Linezolid; Oxazolidinones; Skin Diseases, Bacterial | 2009 |
Synthesis and antibacterial activities of eperezolid analogs with glycinyl substitutions.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus faecalis; Gram-Positive Bacteria; Linezolid; Mass Spectrometry; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxazolidinones; Spectrophotometry, Infrared; Staphylococcus epidermidis; Static Electricity | 2009 |
Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones | 2009 |
Population pharmacokinetic analysis of linezolid in patients with infectious disease: application to lower body weight and elderly patients.
Topics: Acetamides; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Asian People; Body Weight; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Communicable Diseases; Female; Humans; Japan; Linezolid; Male; Middle Aged; Models, Biological; Nonlinear Dynamics; Oxazolidinones; Sex Factors; White People; Young Adult | 2009 |
Use of linezolid in critically ill patients admitted to intensive care units.
Topics: Acetamides; Anti-Bacterial Agents; Catheter-Related Infections; Community-Acquired Infections; Critical Care; Critical Illness; Cross Infection; Disease Susceptibility; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Bacterial; Postoperative Complications; Prospective Studies; Staphylococcal Infections; Thrombocytopenia; Treatment Outcome | 2009 |
Linezolid treatment for gram-positive infections: a retrospective comparison with teicoplanin.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Female; Gram-Positive Bacterial Infections; Humans; Length of Stay; Linezolid; Male; Middle Aged; Oxazolidinones; Pneumonia, Bacterial; Pneumonia, Ventilator-Associated; Retrospective Studies; Teicoplanin | 2009 |
In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models.
Topics: Acetamides; Amidohydrolases; Animals; Anti-Infective Agents; Female; Linezolid; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Peptides; Pneumonia; Staphylococcus aureus; Streptococcus pneumoniae; Thigh | 2009 |
Bone tissue and plasma concentrations of linezolid and vancomycin in rabbits with prosthesis-related infection due to MRSA.
Topics: Acetamides; Animals; Anti-Infective Agents; Bone and Bones; Chromatography, High Pressure Liquid; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Prosthesis-Related Infections; Rabbits; Spectrophotometry, Ultraviolet; Vancomycin | 2009 |
Optic neuropathy following linezolid use in a patient with acute lymphocytic leukemia.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Infections; Humans; Linezolid; Optic Nerve Diseases; Oxazolidinones; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Evaluating aztreonam and ceftazidime pharmacodynamics with Escherichia coli in combination with daptomycin, linezolid, or vancomycin in an in vitro pharmacodynamic model.
Topics: Acetamides; Anti-Bacterial Agents; Aztreonam; Ceftazidime; Daptomycin; Drug Synergism; Drug Therapy, Combination; Escherichia coli; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin | 2009 |
[Effect of linezolid in combination with isoniazid and rifampicin against multidrug resistant Mycobacterium tuberculosis clinical isolates].
Topics: Acetamides; Anti-Infective Agents; Antibiotics, Antitubercular; Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Drug Synergism; Humans; Isoniazid; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Rifampin; Tuberculosis, Multidrug-Resistant | 2009 |
Long-term linezolid treatment in a young child with extensively drug-resistant tuberculosis.
Topics: Acetamides; Antitubercular Agents; Drug Administration Schedule; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuberculosis; Female; Humans; Infant; Linezolid; Oxazolidinones; Tuberculosis, Pulmonary | 2009 |
In vitro 24-hour time-kill studies of vancomycin and linezolid in combination versus methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Drug Antagonism; Drug Synergism; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin | 2009 |
Comment on: Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis.
Topics: Acetamides; Anti-Bacterial Agents; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2009 |
Use of a sensitive chemiluminescence-based assay to evaluate the metabolic suppression activity of linezolid on methicillin-resistant Staphylococcus aureus showing reduced susceptibility to vancomycin.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Luminescent Measurements; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microbial Viability; Oxazolidinones; Protein Synthesis Inhibitors; Staphylococcal Infections; Vancomycin; Vancomycin Resistance | 2009 |
Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacteremia; Bacterial Toxins; Colony Count, Microbial; Cytokines; Exotoxins; Histocytochemistry; Leukocidins; Linezolid; Lung; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Oxazolidinones; Pneumonia, Staphylococcal; Survival Analysis; Treatment Outcome; Virulence Factors | 2009 |
Comment on: Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis.
Topics: Acetamides; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2009 |
Outcomes of invasive infection due to vancomycin-resistant Enterococcus faecium during a recent outbreak.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Comorbidity; Disease Outbreaks; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Hospitals; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Treatment Outcome; United States; Vancomycin Resistance; Virginiamycin | 2009 |
Linezolid vancomycin resistant Enterococcus isolated from clinical samples in Tehran hospitals.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Enterococcus; Gram-Positive Bacterial Infections; Hospitals, Teaching; Humans; Iran; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Prevalence; Serum Bactericidal Test; Teicoplanin; Vancomycin Resistance | 2009 |
Community-acquired methicillin-resistant Staphylococcus aureus and Lemierre syndrome.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Community-Acquired Infections; Daptomycin; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Sepsis; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2009 |
Synthesis and antibacterial activity of a series of alpha-substituted acetylpiperazinyl oxazolidinones.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazolidinones | 2009 |
Pure red cell precursor toxicity by linezolid in a pediatric case.
Topics: Acetamides; Anti-Bacterial Agents; Child, Preschool; Drug Resistance, Multiple, Bacterial; Endocarditis, Bacterial; Erythrocyte Transfusion; Erythroid Precursor Cells; Ferrochelatase; Humans; Linezolid; Male; Mitochondria; Oxazolidinones; Protoporphyrins; Red-Cell Aplasia, Pure; Ribosomes; Streptococcal Infections; Streptococcus mitis | 2009 |
Nosocomial outbreak of linezolid-resistant Enterococcus faecalis infection in a tertiary care hospital.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Typing Techniques; Cluster Analysis; Cross Infection; Disease Outbreaks; DNA Fingerprinting; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecalis; Female; Genotype; Gram-Positive Bacterial Infections; Hospitals; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Sequence Analysis, DNA; Spain; Young Adult | 2009 |
Decreased linezolid uptake in an in vitro-selected linezolid-resistant Staphylococcus epidermidis mutant.
Topics: Acetamides; Anti-Bacterial Agents; Biological Transport; DNA Mutational Analysis; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Selection, Genetic; Sequence Analysis, DNA; Serial Passage; Staphylococcus epidermidis | 2009 |
Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.
Topics: Acetamides; Acute Disease; Aged, 80 and over; Anti-Infective Agents; Eosinophilia; Exanthema; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Nephritis, Interstitial; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Syndrome; Vancomycin | 2009 |
Reduced biofilm production associated with increasing linezolid MICs among linezolid-resistant staphylococci.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Biofilms; Drug Resistance, Bacterial; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus; Young Adult | 2009 |
Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis--authors' response.
Topics: Acetamides; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2009 |
In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and van
Topics: Acetamides; Animals; Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Endocarditis, Bacterial; Enterococcus faecalis; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Rabbits; Vancomycin; Vancomycin Resistance | 2009 |
Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).
Topics: Acetamides; Anti-Bacterial Agents; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Mutation; Oxazolidinones; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Staphylococcus aureus; Tetrazoles | 2009 |
Repeated embolic stroke from an infected aortic arch graft with transesophageal echocardiography-documented mobile vegetation.
Topics: Acetamides; Anti-Bacterial Agents; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Brain; Diffusion Magnetic Resonance Imaging; Echocardiography; Humans; Intracranial Embolism; Linezolid; Male; Middle Aged; Oxazolidinones; Positron-Emission Tomography; Recurrence; Staphylococcal Infections; Staphylococcus aureus; Stroke; Surgical Wound Infection; Transplants; Treatment Outcome | 2009 |
Acute interstitial nephritis associated with linezolid.
Topics: Acetamides; Acute Disease; Anti-Infective Agents; Eosinophilia; Humans; Linezolid; Male; Nephritis, Interstitial; Osteomyelitis; Oxazolidinones; Young Adult | 2009 |
Primary retroperitoneal abscesses due to Rhodococcus equi in a patient with severe nephrotic syndrome: successful antibiotic treatment with linezolid and tigecycline.
Topics: Abdominal Abscess; Acetamides; Actinomycetales Infections; Adult; Anti-Bacterial Agents; Drug Therapy, Combination; Humans; Immunocompromised Host; Injections, Intravenous; Linezolid; Male; Microbial Sensitivity Tests; Minocycline; Nephrotic Syndrome; Oxazolidinones; Retroperitoneal Space; Rhodococcus equi; Tigecycline; Treatment Outcome | 2010 |
Inpatient treatment patterns, outcomes, and costs of skin and skin structure infections because of Staphylococcus aureus.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Daptomycin; Drug Utilization; Drug Utilization Review; Female; Humans; Inpatients; Length of Stay; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Staphylococcal Skin Infections; Treatment Outcome; Vancomycin; Young Adult | 2010 |
In vitro activity of linezolid against Mycobacterium tuberculosis strains isoalted from Western Turkey.
Topics: Acetamides; Antitubercular Agents; Hospitals; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis; Turkey | 2009 |
Linezolid-associated optic neuropathy in a patient with ocular sarcoidosis.
Topics: Acetamides; Aged; Anti-Infective Agents; Eye Diseases; Female; Fluorescein Angiography; Humans; Linezolid; Magnetic Resonance Imaging; Methicillin Resistance; Optic Neuritis; Osteomyelitis; Oxazolidinones; Sarcoidosis; Staphylococcal Infections; Visual Acuity; Visual Field Tests | 2009 |
Fatal lactic acidosis after prolonged linezolid exposure for treatment of multidrug-resistant tuberculosis.
Topics: Acetamides; Acidosis, Lactic; Anti-Infective Agents; Fatal Outcome; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Time Factors; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2009 |
Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.
Topics: Acetamides; Binding Sites; Drug Resistance, Bacterial; Linezolid; Mutation; Oxazolidinones; Protein Structure, Secondary; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Tetrazoles | 2009 |
Correlation between vancomycin MIC values and those of other agents against gram-positive bacteria among patients with bloodstream infections caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cohort Studies; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Retrospective Studies; Staphylococcal Infections; Vancomycin | 2009 |
[Linezolid-induced lactic acidosis].
Topics: Acetamides; Acidosis, Lactic; Aged; Anti-Bacterial Agents; Comorbidity; Dyspnea; Endocarditis, Bacterial; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Oxazolidinones | 2009 |
Linezolid is not suitable as internal standard.
Topics: Acetamides; Humans; Linezolid; Oxazolidinones; Reference Standards | 2010 |
[Serotonin syndrome due to interaction between linezolid, tryptophan, and metoclopramide].
Topics: Acetamides; Drug Interactions; Female; Humans; Linezolid; Metoclopramide; Middle Aged; Oxazolidinones; Serotonin Syndrome; Tryptophan | 2009 |
Daptomycin activity tested against linezolid-nonsusceptible gram-positive clinical isolates.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Enterococcus; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; RNA, Bacterial; RNA, Ribosomal, 23S; Staphylococcus | 2009 |
Linezolid an oral treatment option for staphylococcal liver abscess in chronic granulomatous disease.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Biopsy, Needle; Granulomatous Disease, Chronic; Humans; Linezolid; Liver Abscess; Male; Oxazolidinones; Staphylococcal Infections | 2009 |
Detection of new mutations conferring resistance to linezolid in glycopeptide-intermediate susceptibility Staphylococcus hominis subspecies hominis circulating in an intensive care unit.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Bacterial Typing Techniques; Blood; Cross Infection; DNA Mutational Analysis; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Genotype; Glycopeptides; Humans; Intensive Care Units; Linezolid; Microbial Sensitivity Tests; Mutation, Missense; Oxazolidinones; RNA, Bacterial; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus hominis | 2010 |
Early onset probable linezolid-induced encephalopathy.
Topics: Acetamides; Adult; Alcohol-Induced Disorders, Nervous System; Alcoholism; Anti-Infective Agents; Brain; Causality; Heart Failure; Humans; Linezolid; Liver Cirrhosis; Male; Neurotoxicity Syndromes; Oxazolidinones; Patient Selection; Pneumonia, Staphylococcal; Risk Factors | 2010 |
A refractory case of community-acquired pneumonia.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Asthma; Community-Acquired Infections; Critical Illness; Drug Resistance, Bacterial; Drug Therapy, Combination; Emergency Service, Hospital; Female; Follow-Up Studies; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Oxygen Inhalation Therapy; Pneumonia, Staphylococcal; Radiography, Thoracic; Recurrence; Risk Assessment; Sputum; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2009 |
Linezolid surveillance program results for 2008 (LEADER Program for 2008).
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Prevalence; United States | 2009 |
Zyvox Annual Appraisal of Potency and Spectrum program: linezolid surveillance program results for 2008.
Topics: Acetamides; Anti-Bacterial Agents; Asia; Canada; Drug Resistance, Bacterial; Europe; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Latin America; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Point Mutation; Prevalence; RNA, Bacterial; RNA, Ribosomal, 23S | 2009 |
Linezolid therapy for pediatric thoracic spondylodiscitis due to Staphylococcus aureus sepsis.
Topics: Acetamides; Anti-Bacterial Agents; Diagnosis, Differential; Discitis; Humans; Infant; Linezolid; Magnetic Resonance Imaging; Male; Oxazolidinones; Sepsis; Staphylococcal Infections; Staphylococcus aureus; Thoracic Vertebrae | 2010 |
Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Cephalosporins; Chromatography, High Pressure Liquid; Daptomycin; Disease Models, Animal; Endocarditis, Bacterial; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Rabbits; Random Allocation; Vancomycin | 2010 |
Retrospective cohort chart review study of factors associated with the development of thrombocytopenia in adult Japanese patients who received intravenous linezolid therapy.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Anti-Bacterial Agents; Cohort Studies; Creatine; Female; Humans; Injections, Intravenous; Japan; Linezolid; Male; Middle Aged; Oxazolidinones; Platelet Count; Retrospective Studies; Risk Factors; Thrombocytopenia | 2009 |
Observational studies of salvage treatment for persistent bacteremia: beware of survivor treatment selection bias.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Drug Therapy, Combination; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Salvage Therapy; Staphylococcal Infections; Vancomycin | 2009 |
Polyphyletic emergence of linezolid-resistant staphylococci in the United States.
Topics: Acetamides; Amino Acid Sequence; Anti-Infective Agents; Bacterial Proteins; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Sequence Data; Oxazolidinones; Phylogeny; Ribosomal Proteins; RNA, Ribosomal, 23S; Sequence Homology, Amino Acid; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Staphylococcus epidermidis; United States | 2010 |
Linezolid treatment of a prosthetic joint infection with Staphylococcus lugdunensis in a patient with multiple myeloma.
Topics: Acetamides; Anti-Bacterial Agents; Arthritis; Humans; Linezolid; Male; Middle Aged; Multiple Myeloma; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Treatment Outcome | 2010 |
Linezolid-induced severe hyperbilirubinemia in a patient with decompensated cirrhosis.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacterial Infections; Fibrosis; Humans; Hyperbilirubinemia; Linezolid; Male; Oxazolidinones | 2010 |
Linezolid in the treatment of multidrug-resistant tuberculosis.
Topics: Acetamides; Adolescent; Adult; Aged; Antitubercular Agents; Female; Humans; Linezolid; Male; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Retrospective Studies; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2010 |
What is the optimal dosage of linezolid in treatment of complicated multidrug-resistant tuberculosis?
Topics: Acetamides; Adult; Diabetes Complications; Drug Administration Schedule; Fluoroquinolones; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Smoking; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2009 |
Treatment of vancomycin-intermediate Staphylococcus aureus (VISA) endocarditis with linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Echocardiography; Endocarditis, Bacterial; Fusidic Acid; Humans; Injections, Intravenous; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Mitral Valve; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance | 2010 |
Evaluation of risk factors for coinfection or cocolonization with vancomycin-resistant enterococcus and methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacterial Proteins; Carbon-Oxygen Ligases; Carrier State; Clindamycin; Comorbidity; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Plasmids; Prevalence; Retrospective Studies; Risk Factors; Vancomycin Resistance | 2010 |
Linezolid-resistant methicillin-resistant Staphylococcus aureus isolated after long-term, repeated use of linezolid.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Fatal Outcome; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Staphylococcal Infections | 2009 |
[Serotonin syndrome associated with linezolid use: a case report].
Topics: Acetamides; Adult; Female; Humans; Linezolid; Monoamine Oxidase Inhibitors; Oxazolidinones; Protein Synthesis Inhibitors; Risk Factors; Serotonin Syndrome | 2009 |
Vancomycin-resistant Enterococcus spp.: validation of susceptibility testing and in vitro activity of vancomycin, linezolid, tigecycline and daptomycin.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Proteins; Carbon-Oxygen Ligases; Daptomycin; DNA, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Polymerase Chain Reaction; Reproducibility of Results; Tigecycline; Vancomycin; Vancomycin Resistance | 2010 |
The safety of intraocular linezolid in rabbits.
Topics: Acetamides; Animals; Anti-Infective Agents; Electroretinography; Injections; Intraocular Pressure; Linezolid; Microscopy, Electron; Oxazolidinones; Rabbits; Retina; Vitreous Body | 2010 |
Antibiotic regimen including linezolid for treating prosthetic valve endocarditis with cerebral embolism due to methicillin-susceptible Staphylococcus aureus after failure with oxacillin and teicoplanin.
Topics: Acetamides; Anti-Infective Agents; Aortic Valve; Endocarditis, Bacterial; Heart Valve Prosthesis; Humans; Intracranial Embolism; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxacillin; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Treatment Outcome | 2009 |
[A case of community-acquired MRSA (CA-MRSA) sepsis complicated by meningoencephalitis and cerebral abscess, successfully treated with linezolid].
Topics: Acetamides; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Brain Abscess; Community-Acquired Infections; Female; Follow-Up Studies; Humans; Linezolid; Meningoencephalitis; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Sepsis; Staphylococcal Infections; Time Factors; Treatment Outcome | 2009 |
Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Clostridium perfringens; Drug Resistance, Bacterial; Erythromycin; Humans; Linezolid; Manure; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Ribosomal Proteins; Swine; Thiamphenicol | 2010 |
Incidence of vancomycin-resistant enterococci (VRE) infection in high-risk febrile neutropenic patients colonized with VRE.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Case-Control Studies; Ciprofloxacin; Daptomycin; Enterococcus; Female; Fever; Humans; Incidence; Linezolid; Male; Middle Aged; Neutropenia; Oxazolidinones; Retrospective Studies; Vancomycin; Vancomycin Resistance | 2010 |
[In vitro susceptibility to linezolid in methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus strains].
Topics: Acetamides; Anti-Infective Agents; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Vancomycin Resistance | 2009 |
Linezolid-resistant ST36 methicillin-resistant Staphylococcus aureus associated with prolonged linezolid treatment in two paediatric cystic fibrosis patients.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Bacterial Typing Techniques; Bacteriophage Typing; Child; Cystic Fibrosis; DNA Fingerprinting; Drug Resistance, Bacterial; Genes, rRNA; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Polymorphism, Restriction Fragment Length; Pseudomonas aeruginosa; RNA, Bacterial; RNA, Ribosomal, 23S; Sputum; Staphylococcal Infections; United Kingdom | 2010 |
Effect of linezolid on cytokine production capacity and plasma endotoxin levels in response to lipopolysaccharide stimulation of whole blood.
Topics: Acetamides; Analysis of Variance; Anti-Infective Agents; Blood; Cytokines; Endotoxins; Humans; Interferon-gamma; Interleukin-10; Linezolid; Lipopolysaccharides; Oxazolidinones; Protein Synthesis Inhibitors; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype.
Topics: Acetamides; Anti-Bacterial Agents; Base Sequence; DNA Primers; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Enterococcus faecalis; Humans; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Models, Biological; Oxazolidinones; Phenotype; Point Mutation; RNA, Bacterial; RNA, Ribosomal, 23S; Species Specificity; Staphylococcus aureus | 2010 |
Development and validation of a high performance liquid chromatography method to determine linezolid concentrations in pig pulmonary tissue.
Topics: Acetamides; Animals; Anti-Infective Agents; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Limit of Detection; Linezolid; Lung; Oxazolidinones; Reproducibility of Results; Swine | 2010 |
[Chemotherapy with linezolid for chronic synthetic graft infection].
Topics: Acetamides; Aged; Anti-Infective Agents; Aorta; Blood Vessel Prosthesis; Chronic Disease; Humans; Linezolid; Male; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections | 2010 |
Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Typing Techniques; Disease Outbreaks; DNA Fingerprinting; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Genotype; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Polymerase Chain Reaction; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcal Infections | 2010 |
Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Cephalosporins; Daptomycin; Drug Resistance, Bacterial; Drug Synergism; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Sisomicin; Time Factors | 2010 |
Twenty-month-old patient with distal humerus fracture and concomitant septic arthritis.
Topics: Acetamides; Anti-Bacterial Agents; Arthritis, Infectious; Catheterization, Central Venous; Debridement; Drug Resistance, Multiple, Bacterial; Emergencies; Fracture Fixation, Internal; Fractures, Closed; Humans; Humeral Fractures; Infant; Infusions, Intravenous; Linezolid; Male; Oxazolidinones; Pneumococcal Infections; Pneumococcal Vaccines; Reoperation; Streptococcus pneumoniae; Suppuration; Therapeutic Irrigation | 2010 |
Efficacy and safety of linezolid in immunocompromised children with cancer.
Topics: Acetamides; Age Factors; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Child; Child, Preschool; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Gram-Positive Bacterial Infections; Greece; Hematologic Neoplasms; Humans; Immunocompromised Host; Infant; Infusions, Intravenous; Linezolid; Male; Oxazolidinones; Prospective Studies; Risk Assessment; Severity of Illness Index; Survival Analysis; Treatment Outcome | 2010 |
Linezolid use for treatment of multidrug-resistant and extensively drug-resistant tuberculosis, New York City, 2000-06.
Topics: Acetamides; Adult; Aged; Antitubercular Agents; Bone Marrow Diseases; Child; Female; Gastrointestinal Diseases; Humans; Incidence; Linezolid; Male; Middle Aged; Nervous System Diseases; New York City; Oxazolidinones; Retrospective Studies; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Young Adult | 2010 |
Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis.
Topics: Acetamides; Animals; Antitubercular Agents; Aza Compounds; Disease Models, Animal; Drug Discovery; Ethambutol; Fluoroquinolones; Immunocompetence; Inhalation Exposure; Isoniazid; Linezolid; Mice; Mice, Inbred C57BL; Moxifloxacin; Oxazolidinones; Pyrazinamide; Quinolines; Reproducibility of Results; Rifampin; Tuberculosis, Pulmonary | 2010 |
[Efficacy and tolerability of linezolid therapy in the treatment of orthopedic implant infections caused by gram-positive multiresistant cocci].
Topics: Acetamides; Aged; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Female; Fracture Fixation, Internal; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Osteomyelitis; Oxazolidinones; Prosthesis-Related Infections; Retrospective Studies | 2010 |
Expanded clinical presentation of community-acquired methicillin-resistant Staphylococcus aureus pneumonia.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Clindamycin; Community-Acquired Infections; Female; Follow-Up Studies; Humans; Illinois; Incidence; Linezolid; Male; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Prognosis; Retrospective Studies; RNA, Ribosomal, 23S; Survival Rate; Time Factors; Young Adult | 2010 |
Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; In Vitro Techniques; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Sepsis; Spain; Staphylococcal Infections; Tetrazoles; Vancomycin | 2010 |
Analysis of methods commonly used for glycopeptide and oxazolidinone susceptibility testing in Enterococcus faecium isolates.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Carbon-Oxygen Ligases; DNA, Bacterial; Enterococcus faecium; Glycopeptides; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; RNA, Ribosomal, 23S; Teicoplanin; Vancomycin | 2010 |
Critical pneumonia complicating early-stage pregnancy.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Toxins; Drug Therapy, Combination; Exotoxins; Female; Humans; Leukocidins; Linezolid; Lung; Methicillin-Resistant Staphylococcus aureus; Necrosis; Oxazolidinones; Pneumonia, Staphylococcal; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, First; Radiography; Rifampin; Treatment Outcome; Young Adult | 2010 |
Ocular penetration of topically applied linezolid in a rabbit model.
Topics: Acetamides; Administration, Topical; Animals; Anti-Infective Agents; Aqueous Humor; Biological Availability; Chromatography, High Pressure Liquid; Conjunctiva; Cornea; Gram-Positive Bacteria; Linezolid; Models, Animal; Oxazolidinones; Rabbits | 2010 |
Panton-Valentine leukocidin-producing Staphylococcus aureus necrotising pneumonia: measuring toxin levels in microbiological samples to attest of linezolid clinical efficacy.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacterial Toxins; Drug Monitoring; Exotoxins; Humans; Leukocidins; Linezolid; Necrosis; Oxazolidinones; Pneumonia, Staphylococcal; Sputum; Staphylococcus aureus; Virulence Factors | 2010 |
Dissemination of two international linezolid-resistant Staphylococcus epidermidis clones in Greek hospitals.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Typing Techniques; Cluster Analysis; Cross Infection; DNA Fingerprinting; Drug Resistance, Bacterial; Genotype; Greece; Hospitals; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Mutation, Missense; Oxazolidinones; Point Mutation; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus epidermidis; Young Adult | 2010 |
Intra- and extracellular activity of linezolid against Staphylococcus aureus in vivo and in vitro.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Female; Humans; Linezolid; Mice; Oxazolidinones; Peritonitis; Staphylococcus aureus | 2010 |
Prophylactic oral antibiotics reduce reinfection rates following two-stage revision total knee arthroplasty.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Antibiotic Prophylaxis; Arthroplasty, Replacement, Knee; Ciprofloxacin; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; Knee Prosthesis; Linezolid; Oxazolidinones; Prevalence; Prospective Studies; Prosthesis-Related Infections; Reoperation; Retrospective Studies; Staphylococcal Infections; Staphylococcus; Trimethoprim, Sulfamethoxazole Drug Combination | 2011 |
A rapid high-performance liquid chromatography method to measure linezolid and daptomycin concentrations in human plasma.
Topics: Acetamides; Adult; Aged; Chromatography, High Pressure Liquid; Daptomycin; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Technology, Pharmaceutical | 2010 |
In vitro antimicrobial synergy testing of coagulase-negative staphylococci isolated from prosthetic joint infections using Etest and with a focus on rifampicin and linezolid.
Topics: Acetamides; Anti-Infective Agents; Coagulase; Drug Synergism; Humans; Joint Prosthesis; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Prosthesis-Related Infections; Reproducibility of Results; Rifampin; Staphylococcal Infections; Staphylococcus epidermidis | 2010 |
Linezolid dosing for staphylococcal pneumonia in children.
Topics: Acetamides; Anti-Bacterial Agents; Child; Child, Preschool; Drug Administration Schedule; Humans; Infant; Infant, Newborn; Linezolid; Oxazolidinones; Pneumonia, Staphylococcal | 2009 |
Linezolid penetration into cerebrospinal fluid and brain tissue.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Brain; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones | 2010 |
Increasing pathomorphism of pulmonary tuberculosis: an observational study of slow clinical, microbiological and imaging response of lung tuberculosis to specific treatment. Which role for linezolid?
Topics: Acetamides; Adult; Antitubercular Agents; Drug Administration Schedule; Female; Humans; Linezolid; Male; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2009 |
[Linezolid in the treatment of gram positive coccal infections in critical patients].
Topics: Acetamides; Anti-Bacterial Agents; Cost-Benefit Analysis; Critical Care; Critical Illness; Cross Infection; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Oxazolidinones | 2010 |
Determination of linezolid in human plasma by high-performance liquid chromatography with ultraviolet detection.
Topics: Acetamides; Anti-Infective Agents; Biotransformation; Blood Proteins; Calibration; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Indicators and Reagents; Linezolid; Oxazolidinones; Reproducibility of Results; Spectrophotometry, Ultraviolet | 2010 |
MRSA--too many hurdles to overcome: a study from Central India.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Cefoxitin; Drug Resistance, Multiple, Bacterial; Humans; Incidence; India; Inhibitory Concentration 50; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Prevalence; Staphylococcal Infections; Vancomycin | 2010 |
In vitro evaluation of ceftaroline alone and in combination with tobramycin against hospital-acquired meticillin-resistant Staphylococcus aureus (HA-MRSA) isolates.
Topics: Acetamides; Ceftaroline; Cephalosporins; Cross Infection; Daptomycin; Drug Synergism; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Tobramycin; Vancomycin | 2010 |
A case of lactic acidosis induced by linezolid.
Topics: Acetamides; Acidosis, Lactic; Adult; Anti-Infective Agents; Humans; Linezolid; Male; Oxazolidinones | 2010 |
A case of community-onset meningitis caused by hospital methicillin-resistant Staphylococcus aureus successfully treated with linezolid and rifampicin.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Community-Acquired Infections; Humans; Linezolid; Male; Meningitis, Bacterial; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Rifampin | 2010 |
Severe drug-induced liver injury associated with prolonged use of linezolid.
Topics: Acetamides; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Linezolid; Middle Aged; Oxazolidinones | 2010 |
In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Humans; In Vitro Techniques; Linezolid; Lipoglycopeptides; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Virginiamycin | 2010 |
Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Humans; Legionella pneumophila; Linezolid; Listeria monocytogenes; Microbial Sensitivity Tests; Oxazolidinones; Phagocytes; Rats; Staphylococcus aureus; Staphylococcus epidermidis | 2010 |
Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction.
Topics: Acetamides; Administration, Oral; Aged; Anti-Infective Agents; Blood Urea Nitrogen; Creatinine; Female; Humans; Injections, Intravenous; Japan; Linezolid; Male; Oxazolidinones; Renal Insufficiency; Risk Factors; Thrombocytopenia | 2010 |
Combined meropenem and linezolid as a systemic treatment for postoperative endophthalmitis.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Drug Combinations; Endophthalmitis; Female; Humans; Linezolid; Male; Meropenem; Ophthalmologic Surgical Procedures; Oxazolidinones; Retrospective Studies; Thienamycins; Treatment Outcome | 2010 |
[Linezolid therapy for infectious endocarditis].
Topics: Acetamides; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Endocarditis, Bacterial; Enterococcus faecalis; Female; Humans; Linezolid; Oxazolidinones; Treatment Outcome | 2010 |
Linezolid treatment of shunt-related cerebrospinal fluid infections in children.
Topics: Acetamides; Anti-Infective Agents; Cerebral Ventricles; Cerebrospinal Fluid; Cerebrospinal Fluid Shunts; Child, Preschool; Device Removal; Drug Resistance, Multiple, Bacterial; Female; Humans; Infant; Linezolid; Male; Oxazolidinones; Pneumococcal Infections; Prosthesis-Related Infections; Retrospective Studies; Vancomycin Resistance; Ventriculoperitoneal Shunt | 2010 |
[Necrotizing pneumonia by community-acquired, methicillin-resistant Staphylococcus aureus in Colombia].
Topics: Acetamides; Adult; Anti-Bacterial Agents; Colombia; Combined Modality Therapy; Community-Acquired Infections; Drainage; Endocarditis, Bacterial; Female; Humans; Immunocompromised Host; Kidney Transplantation; Linezolid; Lupus Nephritis; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Necrosis; Oxazolidinones; Pneumonia, Staphylococcal; Postoperative Complications; Respiration, Artificial; Shock, Septic; Thoracostomy; Tomography, X-Ray Computed | 2009 |
Polypyrrole solid phase microextraction: A new approach to rapid sample preparation for the monitoring of antibiotic drugs.
Topics: Acetamides; Anti-Bacterial Agents; Anticoagulants; Aza Compounds; Chromatography, High Pressure Liquid; Daptomycin; Fluoroquinolones; Humans; Hydrogen-Ion Concentration; Linezolid; Moxifloxacin; Oxazolidinones; Polymers; Pyrroles; Quinolines; Salts; Solid Phase Microextraction | 2010 |
Pharmacokinetics and distribution of linezolid in cerebrospinal fluid in children and adolescents.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Cerebral Ventricles; Cerebrospinal Fluid; Child; Child, Preschool; Female; Humans; Hydrocephalus; Infant; Injections, Intravenous; Linezolid; Male; Oxazolidinones; Plasma; Young Adult | 2010 |
Linezolid concentrations in infected soft tissue and bone following repetitive doses in diabetic patients with bacterial foot infections.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacterial Infections; Bone and Bones; Diabetes Mellitus, Type 2; Diabetic Foot; Humans; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones; Plasma; Skin; Soft Tissue Infections | 2010 |
Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study.
Topics: Acetamides; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bone Transplantation; Cefazolin; Clindamycin; Dose-Response Relationship, Drug; Drug Compounding; Drug Stability; Drug Storage; Humans; Linezolid; Microbial Sensitivity Tests; Oxacillin; Oxazolidinones; Prosthesis-Related Infections; Staphylococcus epidermidis; Surgical Wound Infection; Temperature; Transplantation, Homologous; Vancomycin | 2010 |
Hospital policies and practices on prevention and treatment of infections caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Clinical Protocols; Daptomycin; Formularies, Hospital as Topic; Guidelines as Topic; Health Care Surveys; Hospitals; Humans; Infection Control; Linezolid; Methicillin-Resistant Staphylococcus aureus; Minocycline; Organizational Policy; Oxazolidinones; Patient Isolation; Pharmacy Service, Hospital; Staphylococcal Infections; Surveys and Questionnaires; Tigecycline; Vancomycin | 2010 |
First report of Staphylococcal clinical isolates in Mexico with linezolid resistance caused by cfr: evidence of in vivo cfr mobilization.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Female; Humans; Linezolid; Male; Mexico; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; RNA, Bacterial; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus | 2010 |
A community-acquired methicillin-resistant Staphylococcus aureus liver abscess.
Topics: Acetamides; Adult; Anti-Infective Agents; Community-Acquired Infections; Drainage; Humans; Linezolid; Liver Abscess; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Tomography, X-Ray Computed | 2010 |
Quinupristin-dalfopristin versus linezolid for the treatment of vancomycin-resistant Enterococcus faecium bacteraemia: efficacy and development of resistance.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Bacteremia; Chi-Square Distribution; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Logistic Models; Male; Middle Aged; Oxazolidinones; Prognosis; Risk Factors; Treatment Outcome; Vancomycin Resistance; Virginiamycin | 2010 |
Efficacy of the new cephalosporin ceftaroline in the treatment of experimental methicillin-resistant Staphylococcus aureus acute osteomyelitis.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bone and Bones; Bone Marrow; Ceftaroline; Cephalosporins; Disease Models, Animal; Female; Linezolid; Methicillin-Resistant Staphylococcus aureus; Osteomyelitis; Oxazolidinones; Rabbits; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2010 |
Clinical outbreak of linezolid-resistant Staphylococcus aureus in an intensive care unit.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Bacterial Proteins; Disease Outbreaks; Drug Resistance, Bacterial; Female; Genotype; Hospitals, Teaching; Humans; Intensive Care Units; Linezolid; Male; Middle Aged; Oxazolidinones; Spain; Staphylococcal Infections; Staphylococcus aureus | 2010 |
Preserving the effectiveness of antibiotics.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Microbial; Humans; Infection Control; Linezolid; Oxazolidinones; Practice Patterns, Physicians'; Staphylococcal Infections | 2010 |
Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection.
Topics: Acetamides; Aged; Amino Acid Sequence; Anti-Bacterial Agents; Biomarkers; Blotting, Western; Drug Resistance, Bacterial; Gene Expression Profiling; Humans; Ligases; Linezolid; Male; Methyltransferases; Microbial Sensitivity Tests; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Oxazolidinones; Point Mutation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Ribosomal, 23S; Sequence Homology, Amino Acid; Staphylococcal Infections; Staphylococcus aureus; Virulence | 2010 |
Ecthyma gangrenosum mimicking acute invasive fungal sinusitis in an immunocompromised patient.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Diagnosis, Differential; Ecthyma; Humans; Immunocompromised Host; Linezolid; Male; Mycoses; Nasal Mucosa; Ofloxacin; Oxazolidinones; Protein Synthesis Inhibitors; Pseudomonas aeruginosa; Pseudomonas Infections; Pyoderma Gangrenosum; Risk Factors; Sinusitis; Vancomycin | 2010 |
Early immunomodulatory effects of linezolid in a human whole blood endotoxin model.
Topics: Acetamides; Cytokines; Endotoxemia; Enzyme-Linked Immunosorbent Assay; Humans; Immunosuppressive Agents; Linezolid; Lipopolysaccharides; Male; Oxazolidinones; Polymerase Chain Reaction; RNA, Messenger | 2010 |
[Comparative study of the susceptibility to daptomycin and other antimicrobials against Staphylococcus spp. resistant to methicillin and Enterococcus spp. using Wider, E-test, and microdilution methods].
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Enterococcus; Humans; Linezolid; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Vancomycin | 2010 |
Emergence of linezolid-resistant coagulase-negative Staphylococcus in a cancer centre linked to increased linezolid utilization.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Typing Techniques; Cluster Analysis; Coagulase; Disease Outbreaks; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Drug Utilization; Genotype; Humans; Linezolid; Oncology Service, Hospital; Oxazolidinones; Retrospective Studies; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus epidermidis; United States | 2010 |
Catheter-related bacteremia caused by methicillin-resistant coagulase negative staphylococci with elevated minimal inhibitory concentration for vancomycin.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Catheter-Related Infections; Catheterization, Central Venous; Catheters, Indwelling; Chi-Square Distribution; Child; Coagulase; Daptomycin; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Prospective Studies; Staphylococcus; Vancomycin | 2010 |
Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction.
Topics: Acetamides; Aged; Anemia; Anti-Infective Agents; Area Under Curve; Bayes Theorem; Dose-Response Relationship, Drug; Female; Hemoglobins; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Regression Analysis; Renal Insufficiency; Staphylococcal Infections; Thrombocytopenia | 2011 |
Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Oxacillin; Oxazolidinones; Teicoplanin; Vancomycin Resistance | 2010 |
In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates.
Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Daptomycin; Glycopeptides; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Staphylococcus aureus; Vancomycin; Vancomycin Resistance; Virginiamycin | 2010 |
Linezolid treatment for intracranial abscesses caused by methicillin-resistant Staphylococcus aureus--two case reports.
Topics: Acetamides; Adult; Brain Abscess; Decompressive Craniectomy; Epidural Abscess; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Protein Synthesis Inhibitors; Staphylococcal Infections | 2010 |
Linezolid-resistant Staphylococcus aureus isolated from 2006 through 2008 at six hospitals in Japan.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Hospitals; Humans; Japan; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Polymerase Chain Reaction; RNA, Ribosomal, 23S; Staphylococcal Infections | 2011 |
In vitro activity of daptomycin and comparator agents against Staphylococcus aureus isolates from intravenous drug users with right endocarditis.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Cell Membrane; Colony Count, Microbial; Daptomycin; Drug Evaluation, Preclinical; Drug Resistance, Multiple, Bacterial; Endocarditis, Bacterial; Humans; In Vitro Techniques; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Reagent Strips; Staphylococcus aureus; Substance Abuse, Intravenous; Vancomycin Resistance | 2010 |
Successful treatment of vancomycin-resistant Enterococcus faecium ventriculitis with combined intravenous and intraventricular chloramphenicol in a newborn.
Topics: Acetamides; Anti-Bacterial Agents; Cerebral Ventricles; Cerebrospinal Fluid; Chloramphenicol; Encephalitis; Enterococcus faecium; Female; Gentamicins; Gram-Positive Bacterial Infections; Head; Humans; Infant, Newborn; Infusions, Intravenous; Injections, Intraventricular; Linezolid; Lumbosacral Region; Magnetic Resonance Imaging; Oxazolidinones; Pelvis; Radiography; Treatment Outcome; Vancomycin Resistance | 2010 |
Comparative effectiveness of linezolid and vancomycin among a national cohort of patients infected with methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Aged; Anti-Infective Agents; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2010 |
New coated SPME fibers for extraction and fast HPLC determination of selected drugs in human blood.
Topics: Acetamides; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Daptomycin; Humans; Linezolid; Oxazolidinones; Polymers; Pyrroles; Solid Phase Microextraction; Thiophenes | 2010 |
Tolerability of prolonged linezolid therapy in bone and joint infection: protective effect of rifampicin on the occurrence of anaemia?
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anemia; Anti-Bacterial Agents; Arthritis, Infectious; Drug Therapy, Combination; Female; Humans; Incidence; Linezolid; Male; Middle Aged; Nervous System Diseases; Osteoarthritis; Oxazolidinones; Rifampin; Thrombocytopenia; Time Factors; Treatment Outcome | 2010 |
Development and validation of a stability-indicative agar diffusion assay to determine the potency of linezolid in tablets in the presence of photodegradation products.
Topics: Acetamides; Agar; Anti-Infective Agents; Bacillus subtilis; Drug Contamination; Drug Stability; Linezolid; Methods; Microbial Sensitivity Tests; Oxazolidinones; Photolysis; Quality Control; Tablets | 2010 |
In vitro and in vivo activities of linezolid alone and combined with vancomycin and imipenem against Staphylococcus aureus with reduced susceptibility to glycopeptides.
Topics: Acetamides; Animals; Ascitic Fluid; Bacteremia; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; Glycopeptides; Imipenem; Linezolid; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Oxazolidinones; Peritonitis; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2010 |
Penetration of linezolid into rabbit intervertebral discs and surrounding tissues.
Topics: Acetamides; Animals; Anti-Infective Agents; Chromatography, High Pressure Liquid; Fluorescence Polarization Immunoassay; Intervertebral Disc; Linezolid; Male; Oxazolidinones; Rabbits; Staphylococcus aureus; Vancomycin | 2010 |
Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Binding Sites; Drug Resistance, Bacterial; Linezolid; Microbial Sensitivity Tests; Mutation; Mycobacterium smegmatis; Oxazolidinones; Peptidyl Transferases; Protein Binding; RNA, Ribosomal, 23S | 2010 |
The use of linezolid in the treatment of paediatric patients with infections caused by enterococci including strains resistant to vancomycin.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Linezolid; Male; Oxazolidinones; Treatment Outcome; Vancomycin Resistance | 2010 |
Computer assisted knee arthrodesis in a primary case of septic arthritis: a case report.
Topics: Acetamides; Aged; Anti-Infective Agents; Arthritis, Infectious; Arthrodesis; Bone Malalignment; Drug Resistance, Bacterial; Humans; Injections, Intravenous; Knee Joint; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Postoperative Complications; Radiography; Staphylococcal Infections; Surgery, Computer-Assisted; Treatment Outcome | 2011 |
Multicity outbreak of linezolid-resistant Staphylococcus epidermidis associated with clonal spread of a cfr-containing strain.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Typing Techniques; Disease Outbreaks; DNA Fingerprinting; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Genotype; Hospitals; Humans; Linezolid; Ohio; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis | 2010 |
Molecular and epidemiologic characteristics of linezolid-resistant coagulase-negative staphylococci at a tertiary care hospital.
Topics: Acetamides; Anti-Infective Agents; Cross Infection; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Epidemiology; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus; Staphylococcus epidermidis | 2010 |
Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Body Weight; Drug Monitoring; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies | 2010 |
The outcomes of methicillin-resistant Staphylococcus aureus infection after living donor liver transplantation in a Japanese center.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Child, Preschool; Female; Follow-Up Studies; Hospitals, University; Humans; Infant; Linezolid; Liver Transplantation; Living Donors; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Retrospective Studies; Risk Factors; Staphylococcal Infections; Treatment Outcome; Young Adult | 2010 |
An adaptable HPLC method for the analysis of frequently used antibiotics in ocular samples.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Aza Compounds; Cefuroxime; Chromatography, High Pressure Liquid; Contact Lenses, Hydrophilic; Eye; Fluoroquinolones; Gatifloxacin; Linear Models; Linezolid; Moxifloxacin; Oxazolidinones; Quinolines; Rabbits; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Vitreous Body | 2010 |
Analysis of linezolid-associated hematologic toxicities in a large veterans affairs medical center.
Topics: Acetamides; Aged; Anemia; Anti-Infective Agents; Blood Platelets; Female; Hematologic Diseases; Hospitals, Veterans; Humans; Inpatients; Linezolid; Male; Middle Aged; Outpatients; Oxazolidinones; Platelet Count; Retrospective Studies; Thrombocytopenia | 2010 |
Pulmonary nocardiosis masquerading as severe community-acquired pneumonia.
Topics: Acetamides; Adult; Anti-Infective Agents; Community-Acquired Infections; Fever; Humans; Hypoxia; Linezolid; Male; Nocardia Infections; Oxazolidinones; Pneumonia | 2010 |
Molecular analysis of linezolid resistance in clinical Enterococcus faecium isolates by polymerase chain reaction and pyrosequencing.
Topics: Acetamides; Anti-Bacterial Agents; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Enterococcus faecium; Humans; Linezolid; Oxazolidinones; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; RNA, Ribosomal, 23S; Sequence Analysis, DNA | 2011 |
[Vancomycin, what else?].
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Child; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2010 |
Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Linezolid; Methyltransferases; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Ribosomes; Staphylococcus aureus; Structure-Activity Relationship | 2010 |
Clarithromycin significantly increases linezolid serum concentrations.
Topics: Acetamides; Adult; Chromatography, Liquid; Clarithromycin; Clofazimine; Cycloserine; Drug Interactions; Humans; Linezolid; Male; Oxazolidinones; Tandem Mass Spectrometry; Tuberculosis, Pulmonary | 2010 |
Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.
Topics: Acetamides; Anti-Infective Agents; Bacterial Proteins; Drug Resistance, Bacterial; Linezolid; Methyltransferases; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Ribosomal Protein L3; Ribosomal Proteins; Staphylococcus aureus | 2010 |
Comparative in vitro activities of torezolid (DA-7157) against clinical isolates of aerobic and anaerobic bacteria in South Korea.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Linezolid; Molecular Structure; Oxazolidinones; Republic of Korea; Tetrazoles | 2010 |
Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Bacterial Proteins; Drug Resistance, Bacterial; Hospitals; Humans; Lincosamides; Linezolid; Macrolides; Microbial Sensitivity Tests; Mutation, Missense; Oxazolidinones; Point Mutation; Ribosomal Proteins; RNA, Bacterial; RNA, Ribosomal, 23S; Rome; Staphylococcal Infections; Staphylococcus epidermidis; Streptogramin B | 2010 |
Comparison of antimicrobial agents as therapy for experimental endocarditis: caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Infective Agents; Aortic Valve; Colony Count, Microbial; Disease Models, Animal; Endocarditis, Bacterial; Infusions, Intravenous; Injections, Intravenous; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Rats; Rats, Wistar; Teicoplanin; Time Factors; Vancomycin; Virginiamycin | 2010 |
Efficacy of fosfomycin and its combination with linezolid, vancomycin and imipenem in an experimental peritonitis model caused by a Staphylococcus aureus strain with reduced susceptibility to vancomycin.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Ascitic Fluid; Bacteremia; Bacterial Load; Disease Models, Animal; Drug Therapy, Combination; Female; Fosfomycin; Humans; Imipenem; Linezolid; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Oxazolidinones; Peritonitis; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2011 |
What is MRSA?
Topics: Acetamides; Anti-Bacterial Agents; Community-Acquired Infections; Cross Infection; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Vancomycin | 2010 |
Community-acquired methicillin-resistant Staphylococcus aureus meningitis complicated by cerebral infarction. Role of antibiotic combination of linezolid plus levofloxacin.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Cerebral Infarction; Community-Acquired Infections; Drug Therapy, Combination; Humans; Levofloxacin; Linezolid; Male; Meningitis, Bacterial; Methicillin-Resistant Staphylococcus aureus; Ofloxacin; Oxazolidinones; Staphylococcal Infections | 2010 |
Bitter pills for drug companies.
Topics: Acetamides; Drug Approval; Drug Industry; Fraud; gamma-Aminobutyric Acid; Isoxazoles; Linezolid; Motivation; Off-Label Use; Oxazolidinones; Piperazines; Pregabalin; Sulfonamides; Thiazoles; United States | 2010 |
DNA methylase modifications and other linezolid resistance mutations in coagulase-negative staphylococci in Italy.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Typing Techniques; Deoxyribonucleases, Type II Site-Specific; DNA Fingerprinting; DNA Methylation; DNA Modification Methylases; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Hospitals; Humans; Italy; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus hominis | 2010 |
In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Infections; Gram-Positive Bacteria; Linezolid; Male; Mice; Mice, Inbred ICR; Oxazolidinones; Staphylococcus aureus; Vancomycin | 2010 |
Pharmacogenomic strategies against microbial resistance: from bright to bleak to innovative.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Infections; Computational Biology; Daptomycin; Drug Delivery Systems; Drug Resistance, Microbial; Drug Resistance, Multiple, Bacterial; Forecasting; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Minocycline; Oxazolidinones; Pharmacogenetics; Systems Biology; Tigecycline; Virginiamycin | 2010 |
Severe ventilator-associated pneumonia caused by methicillin-resistant Staphylococcus aureus and other pathogens: report of a case successfully managed by serial surveillance cultures of endotracheal aspirates.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bronchoalveolar Lavage; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Pneumonia, Ventilator-Associated; Respiratory Distress Syndrome; Staphylococcal Infections; Vancomycin | 2011 |
In vitro characterization of calcium phosphate biomaterial loaded with linezolid for osseous bone defect implantation.
Topics: Acetamides; Anti-Infective Agents; Apatites; Biocompatible Materials; Calcium Phosphates; Drug Carriers; Humans; Linezolid; Osteomyelitis; Oxazolidinones | 2012 |
Diminished in vitro antibacterial activity of oxacillin against clinical isolates of borderline oxacillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Daptomycin; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxacillin; Oxazolidinones; Penicillin Resistance; Penicillin-Binding Proteins; Plasmids; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2010 |
Serotonin syndrome in an orthopaedic patient secondary to linezolid therapy for MRSA infection.
Topics: Abscess; Acetamides; Aged; Anti-Infective Agents; Hip Joint; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Prosthesis-Related Infections; Recurrence; Serotonin Syndrome; Staphylococcal Infections | 2011 |
Novel daptomycin combinations against daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus in an in vitro model of simulated endocardial vegetations.
Topics: Acetamides; Anti-Infective Agents; Cefepime; Cephalosporins; Daptomycin; Drug Combinations; Endocarditis, Bacterial; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Nafcillin; Oxazolidinones; Trimethoprim, Sulfamethoxazole Drug Combination | 2010 |
Efficacy of usual and high doses of daptomycin in combination with rifampin versus alternative therapies in experimental foreign-body infection by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Daptomycin; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Rats; Rats, Wistar; Rifampin; Staphylococcal Infections; Vancomycin | 2010 |
Comparative activity of telavancin and other antimicrobial agents against methicillin-resistant Staphylococcus aureus isolates collected from 1991 to 2006.
Topics: Acetamides; Aminoglycosides; Anti-Infective Agents; Daptomycin; Linezolid; Lipoglycopeptides; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Tigecycline; Vancomycin | 2010 |
Two pediatric cases of multidrug-resistant tuberculosis treated with linezolid and moxifloxacin.
Topics: Acetamides; Antitubercular Agents; Aza Compounds; Child, Preschool; Emigrants and Immigrants; Female; Fluoroquinolones; Follow-Up Studies; Humans; Infant; Italy; Linezolid; Male; Microbial Sensitivity Tests; Moldova; Moxifloxacin; Oxazolidinones; Quinolines; Romania; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2010 |
Linezolid therapy of brain abscess.
Topics: Acetamides; Anti-Infective Agents; Brain Abscess; Child; Female; Humans; Linezolid; Male; Oxazolidinones | 2010 |
[A case of cerebral abscess due to methicillin-resistant Staphylococcus aureus which is treated with linezolid + rifampin combination].
Topics: Acetamides; Anti-Infective Agents; Brain Abscess; Drug Therapy, Combination; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Postoperative Complications; Rifampin; Staphylococcal Infections; Tomography, X-Ray Computed; Treatment Failure | 2010 |
[Comparison of teicoplanin and linezolid therapies in patients with methicillin-resistant Staphylococcus aureus pneumonia acquired from respiratory intensive care unit].
Topics: Acetamides; Aged; Anti-Bacterial Agents; Anti-Infective Agents; APACHE; Cross Infection; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Respiratory Care Units; Retrospective Studies; Teicoplanin | 2010 |
Observational study of the epidemiology and outcomes of vancomycin-resistant Enterococcus bacteraemia treated with newer antimicrobial agents.
Topics: Acetamides; Aged; Anti-Infective Agents; Bacteremia; Daptomycin; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Vancomycin Resistance | 2011 |
Linezolid-related immune-mediated severe thrombocytopenia.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Humans; Injections, Intravenous; Linezolid; Male; Oxazolidinones; Platelet Count; Thrombocytopenia | 2011 |
Compassionate use of linezolid for adult Taiwanese patients with bone and joint infections.
Topics: Acetamides; Adult; Anti-Infective Agents; Arthritis, Infectious; Compassionate Use Trials; Female; Humans; Linezolid; Male; Osteomyelitis; Oxazolidinones; Retrospective Studies; Staphylococcal Infections; Treatment Outcome | 2010 |
Stability of linezolid activity in an era of mobile oxazolidinone resistance determinants: results from the 2009 Zyvox® Annual Appraisal of Potency and Spectrum program.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Global Health; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Population Surveillance; Species Specificity | 2010 |
Linezolid levels in a patient with biliary tract sepsis, severe hepatic failure and acute kidney injury on sustained low-efficiency dialysis (SLED).
Topics: Acetamides; Acute Kidney Injury; Aged; Anti-Bacterial Agents; APACHE; Biliary Tract Diseases; Cholecystectomy; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Liver Failure; Male; Oxazolidinones; Renal Dialysis; Sepsis; Vancomycin Resistance | 2010 |
Differences in clinical outcomes in patients with vancomycin-resistant enterococci according to linezolid susceptibility.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterococcus; Female; Humans; Linezolid; Male; Middle Aged; Mutation; Oxazolidinones; Retrospective Studies; Risk Factors; Treatment Outcome; Vancomycin Resistance | 2010 |
Treatment of meningitis caused by vancomycin-resistant Enterococcus faecium: high-dose and combination daptomycin therapy.
Topics: Acetamides; Aged; Daptomycin; Drug Therapy, Combination; Enterococcus faecium; Gentamicins; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Meningitis, Bacterial; Middle Aged; Oxazolidinones; Vancomycin; Vancomycin Resistance | 2010 |
[Clinical analysis of 102 blood disease patients with gram positive cocci infection treated with Linezolid].
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Hematologic Diseases; Humans; Linezolid; Oxazolidinones; Staphylococcus aureus | 2010 |
Risk factors associated with the development of thrombocytopenia in patients who received linezolid therapy.
Topics: Acetamides; Aged; Aged, 80 and over; Female; Humans; Linezolid; Male; Middle Aged; Multivariate Analysis; Oxazolidinones; Platelet Count; Retrospective Studies; Risk Factors; Thrombocytopenia | 2011 |
The role of diabetes mellitus in the treatment of skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: results from three randomized controlled trials.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Diabetes Complications; Diabetic Foot; Female; Humans; Length of Stay; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Prospective Studies; Randomized Controlled Trials as Topic; Staphylococcal Skin Infections; Treatment Outcome; Vancomycin | 2011 |
[Two cases of pulmonary gangrene in HIV-infected patients: favorable outcome without surgery].
Topics: Acetamides; Adult; Alcoholism; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Gangrene; Gentamicins; HIV Infections; Humans; Imipenem; Linezolid; Lung; Male; Metronidazole; Necrosis; Ofloxacin; Oxazolidinones; Pneumonia, Bacterial; Pneumonia, Pneumococcal; Smoking; Tomography, X-Ray Computed | 2011 |
Chronic liver disease increases the risk of linezolid-related thrombocytopenia in methicillin-resistant Staphylococcus aureus-infected patients after digestive surgery.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Female; Humans; Linezolid; Liver Diseases; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Multivariate Analysis; Oxazolidinones; Platelet Count; Risk Factors; Staphylococcal Infections; Thrombocytopenia | 2011 |
Comparison of the pharmacokinetic properties of vancomycin, linezolid, tigecyclin, and daptomycin.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Humans; Linezolid; Minocycline; Oxazolidinones; Tigecycline; Vancomycin | 2010 |
Activity of moxifloxacin against intracellular community-acquired methicillin-resistant Staphylococcus aureus: comparison with clindamycin, linezolid and co-trimoxazole and attempt at defining an intracellular susceptibility breakpoint.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Cell Line; Clindamycin; Community-Acquired Infections; Fluoroquinolones; Humans; Linezolid; Macrophages; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microbial Viability; Moxifloxacin; Oxazolidinones; Phagocytosis; Quinolines; Staphylococcal Infections; Trimethoprim, Sulfamethoxazole Drug Combination | 2011 |
Treatment with linezolid or vancomycin in combination with rifampin is effective in an animal model of methicillin-resistant Staphylococcus aureus foreign body osteomyelitis.
Topics: Acetamides; Animals; Foreign Bodies; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Osteomyelitis; Oxazolidinones; Rats; Rats, Wistar; Rifampin; Vancomycin | 2011 |
Comparison of outcomes from daptomycin or linezolid treatment for vancomycin-resistant enterococcal bloodstream infection: A retrospective, multicenter, cohort study.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Cohort Studies; Daptomycin; Data Interpretation, Statistical; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Multivariate Analysis; Oxazolidinones; Prognosis; Retrospective Studies; Treatment Outcome; Vancomycin Resistance | 2010 |
Susceptibility of clinical Mycobacterium tuberculosis isolates to a potentially less toxic derivate of linezolid, PNU-100480.
Topics: Acetamides; Antitubercular Agents; Ethambutol; Isoniazid; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Rifampin; Streptomycin; Tuberculosis, Multidrug-Resistant | 2011 |
Impact of administration of vancomycin or linezolid to critically ill patients with impaired renal function.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Creatinine; Critical Illness; Female; Gram-Positive Bacterial Infections; Humans; Kidney; Linezolid; Male; Metabolic Clearance Rate; Middle Aged; Oxazolidinones; Renal Insufficiency; Retrospective Studies; Vancomycin | 2011 |
Nosocomial outbreak of methicillin- and linezolid-resistant Staphylococcus epidermidis associated with catheter-related infections in intensive care unit patients.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Typing Techniques; Catheter-Related Infections; Cross Infection; Disease Outbreaks; DNA Transposable Elements; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Female; Genotype; Humans; Intensive Care Units; Linezolid; Male; Methicillin; Molecular Typing; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Spain; Staphylococcal Infections; Staphylococcus epidermidis | 2011 |
Cellulitis caused by a methicillin-sensitive Staphylococcus aureus isolate harboring Panton-Valentine toxin in an American soldier returning from Iraq.
Topics: Abscess; Acetamides; Acute Disease; Adult; Anti-Bacterial Agents; Bacterial Toxins; Cellulitis; Drainage; Drug Therapy, Combination; Exotoxins; Fever; Humans; Iraq; Leg; Leukocidins; Linezolid; Magnetic Resonance Imaging; Male; Meropenem; Military Personnel; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Thienamycins; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination | 2011 |
Co-emergence of linezolid-resistant Staphylococcus aureus and Enterococcus faecium in a patient with methicillin-resistant S. aureus pneumonic sepsis.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus faecium; Fatal Outcome; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; RNA, Ribosomal, 23S; Shock, Septic; Staphylococcus aureus; Time Factors | 2011 |
Emergence of linezolid-resistant Staphylococcus aureus after prolonged treatment of cystic fibrosis patients in Cleveland, Ohio.
Topics: Acetamides; Adolescent; Adult; Anti-Infective Agents; Child; Child, Preschool; Cystic Fibrosis; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Female; Humans; Linezolid; Male; Oxazolidinones; Polymerase Chain Reaction; Ribosomal Protein L3; Spectrometry, Mass, Electrospray Ionization; Staphylococcus aureus; Young Adult | 2011 |
Lactic acidosis and linezolid-induced pancytopaenia.
Topics: Acetamides; Acidosis, Lactic; Aged; Anti-Bacterial Agents; Arthritis, Infectious; Drug Therapy, Combination; Humans; Knee Prosthesis; Linezolid; Male; Ofloxacin; Oxazolidinones; Pancytopenia; Prosthesis-Related Infections | 2011 |
Severe acute hypokalaemia secondary to voriconazole. Uncommon pharmacological causes of hypokalaemia.
Topics: Acetamides; Amikacin; Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Invasive; Drug Therapy, Combination; Humans; Hypokalemia; Linezolid; Lung Diseases, Fungal; Male; Middle Aged; Oxazolidinones; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Potassium Chloride; Pyrimidines; Triazoles; Voriconazole | 2011 |
Intra- and extracellular activities of dicloxacillin and linezolid against a clinical Staphylococcus aureus strain with a small-colony-variant phenotype in an in vitro model of THP-1 macrophages and an in vivo mouse peritonitis model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Dicloxacillin; Doublecortin Protein; Electrophoresis, Gel, Pulsed-Field; Female; Humans; Linezolid; Macrophages; Mice; Oxazolidinones; Peritonitis; Phenotype; Staphylococcal Infections; Staphylococcus aureus | 2011 |
Susceptibility patterns of coagulase-negative staphylococci to several newer antimicrobial agents in comparison with vancomycin and oxacillin.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Daptomycin; DNA, Ribosomal; Linezolid; Lipoglycopeptides; Microbial Sensitivity Tests; Micrococcal Nuclease; Minocycline; Oxacillin; Oxazolidinones; Penicillin-Binding Proteins; Polymerase Chain Reaction; Staphylococcus; Tigecycline; Vancomycin | 2011 |
In vitro electrophysiological investigations of the acute effects of linezolid and novel oxazolidinones on central nervous system neurons.
Topics: Acetamides; Animals; Anti-Infective Agents; Hippocampus; Linezolid; Neurons; Nucleus Accumbens; Oxazolidinones; Patch-Clamp Techniques; Rats; Synaptic Transmission; Triazoles | 2011 |
Nonadherence to oral linezolid after hospitalization: a retrospective claims analysis of the incidence and consequence of claim reversals.
Topics: Acetamides; Administration, Oral; Ambulatory Care; Anti-Bacterial Agents; Drug Costs; Health Expenditures; Hospitalization; Humans; Insurance Claim Review; Linezolid; Medicare; Multivariate Analysis; Oxazolidinones; Patient Compliance; Retrospective Studies; United States | 2010 |
Hollow porous implants filled with mesoporous silica particles as a two-stage antibiotic-eluting device.
Topics: Acetamides; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Implants; Linezolid; Microspheres; Oxazolidinones; Particle Size; Porosity; Silicon Dioxide; Staphylococcal Infections; Staphylococcus aureus | 2011 |
Nickel-catalyzed amination of aryl sulfamates.
Topics: Acetamides; Amination; Amines; Anti-Bacterial Agents; Catalysis; Linezolid; Morpholines; Nickel; Oxazolidinones; Sulfonic Acids | 2011 |
Experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus treated with a polylactide carrier releasing linezolid.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Osteomyelitis; Oxazolidinones; Polyesters; Rabbits; Staphylococcal Infections; Treatment Outcome | 2011 |
Comparison of community-associated and health care-associated methicillin-resistant Staphylococcus aureus in Canada: results of the CANWARD 2007-2009 study.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Toxins; Canada; Child; Child, Preschool; Community-Acquired Infections; Cross Infection; Daptomycin; DNA, Bacterial; Drug Resistance, Bacterial; Exotoxins; Female; Hospitals; Humans; Infant; Leukocidins; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Minocycline; Oxazolidinones; Staphylococcal Infections; Tigecycline; Vancomycin Resistance | 2011 |
Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Genes, rRNA; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mutation; Oxazolidinones | 2011 |
Meropenem/clavulanate and linezolid treatment for extensively drug-resistant tuberculosis.
Topics: Acetamides; Adolescent; Antitubercular Agents; Clavulanic Acid; Extensively Drug-Resistant Tuberculosis; Female; Humans; Linezolid; Meropenem; Oxazolidinones; Thienamycins; Treatment Outcome | 2011 |
Linezolid in the treatment of multidrug-resistant/extensively drug-resistant tuberculosis in paediatric patients: experience of a paediatric infectious diseases unit.
Topics: Acetamides; Adolescent; Antitubercular Agents; Child; Child, Preschool; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Female; Humans; Linezolid; Male; Oxazolidinones; Treatment Outcome | 2011 |
Linezolid for endocarditis: a case series of 14 patients.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Endocarditis, Bacterial; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Serum Bactericidal Test; Treatment Outcome | 2011 |
Linezolid combined with trimethoprim-sulfamethoxazole therapy for the treatment of disseminated nocardiosis.
Topics: Abscess; Acetamides; Anti-Bacterial Agents; Drug Therapy, Combination; Humans; Immunocompromised Host; Linezolid; Male; Middle Aged; Nocardia Infections; Opportunistic Infections; Oxazolidinones; Pericardial Effusion; Trimethoprim, Sulfamethoxazole Drug Combination | 2011 |
Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model.
Topics: Acetamides; Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Azithromycin; Capnocytophaga; Coculture Techniques; Coinfection; Drug Resistance, Bacterial; Fluoroquinolones; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Humans; Linezolid; Metronidazole; Microbial Interactions; Minocycline; Moxifloxacin; Oxazolidinones; Penicillin G; Peptostreptococcus; Peri-Implantitis; Periodontitis; Quinolines; Sulbactam | 2011 |
Clinical experience with linezolid for the treatment of neurosurgical infections.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Cohort Studies; Craniotomy; Female; Humans; Linezolid; Male; Middle Aged; Neurosurgical Procedures; Oxazolidinones; Prosthesis-Related Infections; Retrospective Studies; Spain; Surgical Wound Infection; Young Adult | 2011 |
Linezolid interaction with serotonin reuptake inhibitors: report of two cases and incidence assessment.
Topics: Acetamides; Anti-Infective Agents; Citalopram; Drug Interactions; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Pain; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Sertraline; Staphylococcal Infections; Tremor | 2010 |
[Nosocomial spread of linezolid-resistant Staphylococcus hominis in two hospitals in Majorca].
Topics: Acetamides; Anti-Infective Agents; Cross Infection; Drug Resistance, Bacterial; Female; Humans; Linezolid; Male; Oxazolidinones; Spain; Staphylococcal Infections; Staphylococcus hominis | 2011 |
Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Linezolid; Methyltransferases; Mutation; Oxazolidinones; Staphylococcus aureus | 2011 |
Linezolid-associated hypoglycemia in a 64-year-old man with type 2 diabetes.
Topics: Acetamides; Cellulitis; Diabetes Mellitus, Type 2; Humans; Hypoglycemia; Hypoglycemic Agents; Linezolid; Male; Middle Aged; Oxazolidinones | 2011 |
Comparison of in vitro efficacy of linezolid and vancomycin by determining their minimum inhibitory concentrations against methicillin resistant Staphylococcus aureus (MRSA).
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Hospitals, Military; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Vancomycin | 2011 |
Linezolid and clindamycin improve the outcome of severe, necrotizing pneumonia due to community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA).
Topics: Acetamides; Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Clindamycin; Combined Modality Therapy; Community-Acquired Infections; Drug Therapy, Combination; Echinocandins; Female; Hemofiltration; Humans; Hydrocortisone; Linezolid; Lipopeptides; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Necrosis; Oxazolidinones; Oxygen Inhalation Therapy; Pneumonia, Bacterial; Pulmonary Aspergillosis; Respiration, Artificial; Shock, Septic; Staphylococcal Infections | 2011 |
Linezolid-resistant enterococci in Greece: epidemiological characteristics.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Greece; Hospitals; Humans; Intensive Care Units; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Phenotype; RNA, Ribosomal, 23S; Sequence Analysis, RNA | 2011 |
[Role of daptomycin in the treatment of infections in patients with hematological malignancies].
Topics: Acetamides; Anti-Bacterial Agents; Antineoplastic Agents; Daptomycin; Databases, Factual; Europe; Glycopeptides; Gram-Positive Bacterial Infections; Hematologic Neoplasms; Humans; Immunocompromised Host; Kidney Diseases; Linezolid; Microbial Sensitivity Tests; Minocycline; Multicenter Studies as Topic; Neutropenia; Oxazolidinones; Registries; Retrospective Studies; Risk Factors; Tigecycline; Treatment Outcome | 2010 |
Early life-threatening lactic acidosis following a single infusion of linezolid.
Topics: Acetamides; Acidosis, Lactic; Aged, 80 and over; Critical Care; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Infusions, Intravenous; Linezolid; Male; Oxazolidinones | 2011 |
Interaction between linezolid and Mycobacterium tuberculosis in an experimental in vitro model.
Topics: Acetamides; Antitubercular Agents; Drug Resistance, Bacterial; Genes, Bacterial; Humans; In Vitro Techniques; Linezolid; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2011 |
Comparative activity of linezolid against respiratory tract infection isolates of Staphylococcus aureus: an 11-year report from the SENTRY Antimicrobial Surveillance Program.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Respiratory Tract Infections; Staphylococcal Infections; Staphylococcus aureus | 2011 |
Global in vitro activity of tigecycline and linezolid against Gram-positive organisms collected between 2004 and 2009.
Topics: Acetamides; Anti-Bacterial Agents; Czech Republic; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Staphylococcus aureus; Streptococcus pneumoniae; Tigecycline | 2011 |
Comparative in vitro activity of telavancin, vancomycin and linezolid against heterogeneously vancomycin-intermediate Staphylococcus aureus (hVISA).
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Humans; Linezolid; Lipoglycopeptides; Microbial Sensitivity Tests; Microbial Viability; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Time Factors; Vancomycin; Vancomycin Resistance | 2011 |
In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Female; Humans; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Oxazolidinones; Serum; Staphylococcal Infections; Staphylococcus aureus; Tetrazoles; Thigh | 2011 |
Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model.
Topics: Acetamides; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Feces; Gastrointestinal Tract; Humans; In Vitro Techniques; Linezolid; Metronidazole; Microbial Sensitivity Tests; Oxazolidinones | 2011 |
Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Pyrimidines; Structure-Activity Relationship; Thiocarbamates | 2011 |
Clinical experience of linezolid in bone marrow transplantation patients.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Bone Marrow Transplantation; Female; Humans; Leukopenia; Linezolid; Male; Middle Aged; Neutropenia; Oxazolidinones; Platelet Count; Platelet Transfusion; Retrospective Studies; Thrombocytopenia; Transplantation, Homologous; Young Adult | 2010 |
Ocular penetration of linezolid after oral administration in rabbits.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Endophthalmitis; Female; Half-Life; Linezolid; Oxazolidinones; Rabbits; Reproducibility of Results; Tissue Distribution; Vitreous Body | 2011 |
Clinical experience with linezolid in infants and children.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Linezolid; Oxazolidinones; Treatment Outcome | 2011 |
In vitro activity of linezolid, tigecycline, and daptomycin on methicillin-resistant Staphylococcus aureus blood isolates from adult patients, 2006-2008: stratified analysis by vancomycin MIC.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacteremia; Blood; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Staphylococcal Infections; Taiwan; Tigecycline; Vancomycin | 2011 |
Does linezolid modulate lung innate immunity in a murine model of methicillin-resistant Staphylococcus aureus pneumonia?
Topics: Acetamides; Analysis of Variance; Animals; Anti-Infective Agents; Apoptosis; Confidence Intervals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunity, Innate; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Neutrophils; Oxazolidinones; Peroxidase; Pneumonia, Staphylococcal; Random Allocation; Survival Rate; Treatment Outcome; Vancomycin | 2011 |
Activity of fusidic acid against extracellular and intracellular Staphylococcus aureus: influence of pH and comparison with linezolid and clindamycin.
Topics: Acetamides; Anti-Bacterial Agents; Cell Line; Clindamycin; Colony Count, Microbial; Culture Media; Fusidic Acid; Humans; Hydrogen-Ion Concentration; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Monocytes; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2011 |
Reversion of sulfenamide prodrugs in the presence of free thiol-containing proteins.
Topics: Acetamides; Cell Cycle Proteins; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Stability; Humans; Hydrogen-Ion Concentration; Kinetics; Linezolid; Membrane Proteins; Mutation; Oxazolidinones; Plasma; Prodrugs; Protein Tyrosine Phosphatases; Serum Albumin; Sulfamerazine; Sulfhydryl Compounds; Technology, Pharmaceutical | 2011 |
In vitro efficacy of antimicrobial agents against high-inoculum or biofilm-embedded meticillin-resistant Staphylococcus aureus with vancomycin minimal inhibitory concentrations equal to 2 μg/mL (VA2-MRSA).
Topics: Acetamides; Anti-Infective Agents; Biofilms; Drug Synergism; Drug Therapy, Combination; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Stem Cells; Tigecycline; Vancomycin | 2011 |
Preface. The evidence for the clinical role of linezolid beyond its licence.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2011 |
Linezolid-associated peripheral and optic neuropathy in children.
Topics: Acetamides; Adolescent; Anti-Infective Agents; Argentina; Child; Child, Preschool; Female; Humans; Incidence; Infant; Infant, Newborn; Infections; Linezolid; Male; Optic Nerve Diseases; Oxazolidinones; Peripheral Nervous System Diseases; Risk Factors | 2011 |
A regioselective synthesis of some new pyrazol-1'-ylpyrazolo[1,5-a]pyrimidines in aqueous medium and their evaluation as antimicrobial agents.
Topics: Acetamides; Alternaria; Anti-Bacterial Agents; Antifungal Agents; Aspergillus; Bacillus cereus; Escherichia coli; Fusarium; Gentamicins; Helminthosporium; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Pseudomonas aeruginosa; Pyrazoles; Pyrimidines; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship | 2011 |
Linezolid in the central nervous system: comparison between cerebrospinal fluid and plasma pharmacokinetics.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Cerebrospinal Fluid; Cerebrospinal Fluid Shunts; Chromatography, High Pressure Liquid; Female; Humans; Infusions, Intravenous; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Plasma; Time Factors | 2011 |
[Linezolid use in an intensive care unit].
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cross Infection; Drug Utilization; Female; France; Gram-Positive Bacterial Infections; Guideline Adherence; Hospitals, University; Humans; Intensive Care Units; Linezolid; Male; Middle Aged; Oxazolidinones; Practice Guidelines as Topic; Retrospective Studies | 2011 |
Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression.
Topics: 5-Hydroxytryptophan; Acetamides; Animals; Antidepressive Agents; Behavior; Depression; Disease Models, Animal; Drug Evaluation, Preclinical; Hypothermia; Linezolid; Male; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Oxazolidinones; Rats; Rats, Wistar; Reserpine | 2011 |
Staphylococcus aureus with decreased susceptibility to glycopeptides in cystic fibrosis patients.
Topics: Acetamides; Adolescent; Adult; Anti-Infective Agents; Child; Cystic Fibrosis; Drug Resistance, Bacterial; Female; Glycopeptides; Humans; Linezolid; Male; Oxazolidinones; Pneumonia, Bacterial; Staphylococcal Infections; Staphylococcus aureus; Young Adult | 2011 |
An uncommon side-effect of linezolid.
Topics: Acetamides; Aged; Anti-Infective Agents; Female; Humans; Linezolid; Oxazolidinones; Tongue Diseases; Urinary Tract Infections | 2012 |
Extensively drug-resistant tuberculosis: New Zealand's first case and the challenges of management in a low-prevalence country.
Topics: Acetamides; Adult; Aminosalicylic Acid; Antitubercular Agents; Aza Compounds; Cycloserine; Emigrants and Immigrants; Extensively Drug-Resistant Tuberculosis; Fluoroquinolones; Humans; Imipenem; Linezolid; Lymph Nodes; Male; Moxifloxacin; Myanmar; New Zealand; Oxazolidinones; Quinolines; Radiography | 2011 |
Low fitness cost of the multidrug resistance gene cfr.
Topics: Acetamides; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Methyltransferases; Microbial Sensitivity Tests; Oxazolidinones; RNA, Ribosomal; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus | 2011 |
Successful treatment of methicillin-resistant Staphylococcus aureus mitral valve endocarditis with sequential linezolid and telavancin monotherapy following daptomycin failure.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Daptomycin; Echocardiography, Transesophageal; Endocarditis, Bacterial; Humans; Linezolid; Lipoglycopeptides; Magnetic Resonance Imaging; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mitral Valve; Oxazolidinones; Paraparesis; Staphylococcal Infections; Treatment Failure | 2011 |
Diagnosis and management of community-acquired pneumonia in adults.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Anti-Infective Agents; beta-Lactams; Community-Acquired Infections; Diagnosis, Differential; Doxycycline; Drug Therapy, Combination; Fluoroquinolones; Humans; Influenza Vaccines; Linezolid; Macrolides; Oxazolidinones; Pneumococcal Vaccines; Pneumonia, Bacterial; Practice Guidelines as Topic; Risk Factors; Treatment Outcome; United States; Vancomycin | 2011 |
Activity of vancomycin, ciprofloxacin, daptomycin, and linezolid against coagulase-negative staphylococci bacteremia.
Topics: Acetamides; Bacteremia; Catheter-Related Infections; Ciprofloxacin; Cross Infection; Daptomycin; Drug Resistance, Multiple, Bacterial; Hospital Departments; Hospitals, University; Humans; Length of Stay; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Spain; Staphylococcal Infections; Staphylococcus epidermidis; Staphylococcus haemolyticus; Staphylococcus hominis; Vancomycin | 2011 |
LEADER Program results for 2009: an activity and spectrum analysis of linezolid using 6,414 clinical isolates from 56 medical centers in the United States.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterococcus; Humans; Interspersed Repetitive Sequences; Linezolid; Longitudinal Studies; Microbial Sensitivity Tests; Oxazolidinones; Polymorphism, Single Nucleotide; RNA, Ribosomal, 23S; Staphylococcus; Staphylococcus aureus; Streptococcus; Streptococcus agalactiae; Streptococcus pneumoniae; United States; Viridans Streptococci | 2011 |
Linezolid in the treatment of methicillin-resistant staphylococcal post-neurosurgical meningitis: a series of 17 cases.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Cross Infection; Female; Humans; Linezolid; Male; Meningitis, Bacterial; Methicillin-Resistant Staphylococcus aureus; Neurosurgical Procedures; Oxazolidinones; Postoperative Complications; Prosthesis-Related Infections; Retrospective Studies; Staphylococcal Infections | 2011 |
Influence of linezolid clearance on the induction of thrombocytopenia and reduction of hemoglobin.
Topics: Acetamides; Aged; Aged, 80 and over; Anemia; Anti-Infective Agents; Bayes Theorem; Chromatography, High Pressure Liquid; Creatinine; Female; Hemoglobins; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Models, Biological; Oxazolidinones; Platelet Count; Pneumonia; Renal Insufficiency; Staphylococcal Infections; Thrombocytopenia | 2011 |
[Microbial spectrum of nosocomial pneumonia in traumatological patients].
Topics: Acetamides; Aged; Anti-Bacterial Agents; Arthroplasty, Replacement, Hip; Bacteria; Carbapenems; Cross Infection; Drug Resistance, Microbial; Escherichia coli; Female; Hospitals; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Pneumonia, Bacterial; Pseudomonas aeruginosa; Staphylococcus aureus; Streptococcus pneumoniae; Vancomycin; Wounds and Injuries | 2011 |
Linezolid plus rifampin as a salvage therapy in prosthetic joint infections treated without removing the implant.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Follow-Up Studies; Hip Prosthesis; Humans; Knee Prosthesis; Linezolid; Male; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Rifampin; Salvage Therapy | 2011 |
Is linezolid a risk factor for Gram-negative bacillus infections in intensive care unit patients? A comparative study with vancomycin.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Comorbidity; Cross Infection; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Intensive Care Units; Length of Stay; Linezolid; Male; Middle Aged; Oxazolidinones; Renal Insufficiency; Retrospective Studies; Risk Factors; Vancomycin | 2011 |
Activity of ceftaroline and epidemiologic trends in Staphylococcus aureus isolates collected from 43 medical centers in the United States in 2009.
Topics: Acetamides; Bacterial Toxins; Ceftaroline; Cephalosporins; Clindamycin; Daptomycin; Electrophoresis, Gel, Pulsed-Field; Erythromycin; Exotoxins; Leukocidins; Levofloxacin; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mupirocin; Ofloxacin; Oxacillin; Oxazolidinones; Polymerase Chain Reaction; Staphylococcus aureus; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; United States; Vancomycin | 2011 |
Periscapular abscess: unusual cause of shoulder pain in children.
Topics: Abscess; Acetamides; Anti-Infective Agents; Arthritis, Infectious; Child; Diabetes Complications; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Scapula; Shoulder Joint; Shoulder Pain; Staphylococcal Infections; Treatment Outcome | 2012 |
Poly(3-alkylthiophenes): new sorption materials for solid phase microextraction of drugs isolated from human plasma.
Topics: Acetamides; Adsorption; Chromatography, Liquid; Humans; Linezolid; Materials Testing; Microscopy, Electron, Scanning; Molecular Structure; Oxazolidinones; Oxazolone; Polymers; Solid Phase Microextraction; Stainless Steel; Thiophenes | 2011 |
Successful treatment of pediatric endocarditis and pericarditis due to MRSA with linezolid.
Topics: Acetamides; Anti-Infective Agents; Endocarditis, Bacterial; Humans; Infant; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pericarditis; Staphylococcal Infections; Treatment Outcome | 2011 |
Metacarpal coccidioidal osteomyelitis.
Topics: Abscess; Acetamides; Anti-Bacterial Agents; Antifungal Agents; Coccidioides; Coccidioidomycosis; Fluconazole; Granuloma; Humans; Linezolid; Magnetic Resonance Imaging; Male; Metacarpal Bones; Middle Aged; Osteomyelitis; Oxazolidinones; Radiography; Treatment Outcome | 2011 |
Clinical pharmacokinetic/pharmacodynamic profile of linezolid in severely ill intensive care unit patients.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Area Under Curve; Critical Illness; Drug Resistance, Multiple, Bacterial; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Treatment Outcome | 2011 |
The antistaphylococcal pharmacodynamics of linezolid alone and in combination with doxycycline in an in vitro dynamic model.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Area Under Curve; Doxycycline; Drug Interactions; Drug Therapy, Combination; Linezolid; Microbial Sensitivity Tests; Models, Biological; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2011 |
In vitro activity of daptomycin, linezolid and rifampicin on Staphylococcus epidermidis biofilms.
Topics: Acetamides; Biofilms; Colony Count, Microbial; Daptomycin; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Rifampin; Staphylococcal Infections; Staphylococcus epidermidis | 2011 |
In vitro pharmacokinetic/pharmacodynamic activity of NXL103 versus clindamycin and linezolid against clinical Staphylococcus aureus and Streptococcus pyogenes isolates.
Topics: Acetamides; Anti-Bacterial Agents; Clindamycin; Drug Combinations; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Stem Cells; Streptococcal Infections; Streptococcus pyogenes; Streptogramin A; Streptogramin B | 2011 |
Use of linezolid in infants and children: a retrospective multicentre study of the Italian Society for Paediatric Infectious Diseases.
Topics: Acetamides; Adolescent; Child; Child, Preschool; Drug Resistance, Bacterial; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Italy; Linezolid; Male; Mycobacterium; Mycobacterium Infections; Oxazolidinones; Retrospective Studies; Treatment Outcome | 2011 |
Linezolid does not show advantages over vancomycin in modulating the pulmonary immune response: how should we conciliate these new findings with the Zephyr trial results?
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Clinical Trials as Topic; Disease Models, Animal; Humans; Immunity, Innate; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Oxazolidinones; Pneumonia, Staphylococcal; Risk Assessment; Treatment Outcome; Vancomycin | 2011 |
Outbreak of linezolid-resistant Staphylococcus haemolyticus in an Italian intensive care unit.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Disease Outbreaks; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Genotype; Humans; Intensive Care Units; Italy; Linezolid; Male; Microbial Sensitivity Tests; Molecular Typing; Oxazolidinones; Point Mutation; Staphylococcal Infections; Staphylococcus haemolyticus | 2012 |
Detection of the staphylococcal multiresistance gene cfr in Proteus vulgaris of food animal origin.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; DNA Transposable Elements; DNA, Ribosomal; Drug Resistance, Multiple, Bacterial; Fimbriae Proteins; Food Microbiology; Food Safety; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Proteus vulgaris; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Staphylococcus; Sus scrofa; Thiamphenicol | 2011 |
Hardware preservation after sternal wound infection in a lung transplant recipient.
Topics: Acetamides; Anti-Bacterial Agents; Bone Plates; Bone Screws; Daptomycin; Debridement; Humans; Idiopathic Pulmonary Fibrosis; Infusions, Intravenous; Linezolid; Lung Transplantation; Male; Middle Aged; Negative-Pressure Wound Therapy; Oxazolidinones; Postoperative Care; Staphylococcal Infections; Sternotomy; Surgical Wound Infection; Wound Closure Techniques | 2011 |
Implant stability in the treatment of MRSA bone implant infections with linezolid versus vancomycin in a rabbit model.
Topics: Acetamides; Animals; Anti-Infective Agents; Biomechanical Phenomena; Female; Femur; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Prostheses and Implants; Prosthesis-Related Infections; Rabbits; Staphylococcal Infections; Titanium; Vancomycin | 2012 |
A new way of solid-phase microextraction fibers preparation for selected antibiotic drug determination by HPLC-MS.
Topics: Acetamides; Anti-Infective Agents; Chromatography, High Pressure Liquid; Humans; Linear Models; Linezolid; Mass Spectrometry; Models, Chemical; Oxazolidinones; Ozone; Polymers; Pyrroles; Reproducibility of Results; Solid Phase Microextraction; Thiophenes | 2011 |
The MUT056399 inhibitor of FabI is a new antistaphylococcal compound.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Benzamides; Drug Resistance, Multiple, Bacterial; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Escherichia coli; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Female; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Phenyl Ethers; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2011 |
Telavancin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Daptomycin; Humans; Linezolid; Lipoglycopeptides; Methicillin-Resistant Staphylococcus aureus; Minocycline; Osteomyelitis; Oxazolidinones; Staphylococcal Infections; Tigecycline; Vancomycin | 2011 |
Successful therapy of treatment-emergent, non-clonal daptomycin-non-susceptible Enterococcus faecium infections.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Vancomycin | 2011 |
Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis.
Topics: Acetamides; Anti-Bacterial Agents; Cerebrospinal Fluid; Humans; Linezolid; Male; Meningitis, Bacterial; Middle Aged; Oxazolidinones; Postoperative Complications; Protein Binding; Proteins; Serum | 2011 |
Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children.
Topics: Acetamides; Acidosis, Lactic; Adolescent; Anti-Bacterial Agents; Fatal Outcome; Female; Humans; Infant; Lactic Acid; Linezolid; Male; Mitochondria; Oxazolidinones | 2011 |
Combination therapy with daptomycin, linezolid, and rifampin as treatment option for MRSA meningitis and bacteremia.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Daptomycin; Drug Therapy, Combination; Humans; Linezolid; Male; Meningitis, Bacterial; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Rifampin; Staphylococcal Infections; Treatment Outcome | 2011 |
[Shifts in minimum inhibitory concentration of linezolid to Stapylococcus aureus strains isolated from 2007 to 2009].
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2011 |
Proteomic and transcriptomic analysis of linezolid resistance in Streptococcus pneumoniae.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Bacterial; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Bacterial; Genome, Bacterial; Linezolid; Mutation; Oligonucleotide Array Sequence Analysis; Oxazolidinones; Proteome; Proteomics; RNA; Streptococcus pneumoniae; Transcription, Genetic; Transcriptome | 2011 |
Linezolid safety, tolerability and efficacy to treat multidrug- and extensively drug-resistant tuberculosis.
Topics: Acetamides; Adult; Amikacin; Antitubercular Agents; Capreomycin; Drug-Related Side Effects and Adverse Reactions; Extensively Drug-Resistant Tuberculosis; Female; Fluoroquinolones; Humans; Infectious Disease Medicine; Isoniazid; Kanamycin; Linezolid; Male; Middle Aged; Oxazolidinones; Rifampin | 2011 |
Correlation between serum linezolid concentration and the development of thrombocytopenia.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Dose-Response Relationship, Drug; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Platelet Count; Pneumonia; Prospective Studies; Thrombocytopenia | 2012 |
Rapid-onset, linezolid-induced lactic acidosis in MELAS.
Topics: Acetamides; Acidosis, Lactic; Anti-Bacterial Agents; Humans; Linezolid; Male; MELAS Syndrome; Oxazolidinones; Young Adult | 2011 |
Mycobacterium chelonae infection involving the auricle.
Topics: Acetamides; Adult; Anti-Infective Agents; Clarithromycin; Ear Auricle; Humans; Linezolid; Lymph Nodes; Lymphadenitis; Male; Microbial Sensitivity Tests; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Neck; Oxazolidinones; Skin Diseases, Bacterial; Treatment Outcome | 2012 |
[Actual aspects of sepsis].
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Carbapenems; Cefepime; Cephalosporins; Drug Resistance, Microbial; Enterobacteriaceae; Female; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Hospitals; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Retrospective Studies; Russia; Sepsis; Vancomycin | 2011 |
Potential for linezolid-related blindness: a review of spontaneous adverse event reports.
Topics: Acetamides; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anti-Infective Agents; Bayes Theorem; Blindness; Cohort Studies; Databases, Factual; Female; Glaucoma; Humans; Linezolid; Male; Middle Aged; Optic Nerve Diseases; Oxazolidinones; Retrospective Studies; United States; United States Food and Drug Administration | 2011 |
Efficacy of linezolid compared to vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated pigs.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Interleukin-6; Interleukin-8; Linezolid; Lung; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Pneumonia, Ventilator-Associated; Respiration, Artificial; Swine; Tumor Necrosis Factor-alpha; Vancomycin | 2012 |
[In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates to vancomycin, teicoplanin, linezolide and daptomycin].
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Vancomycin | 2011 |
Resistance patterns and occurrence of virulence determinants among GRE strains in southwestern Poland.
Topics: Acetamides; Agar; Anti-Bacterial Agents; Biofilms; Daptomycin; Deoxyribonucleases; Drug Resistance; Drug Resistance, Bacterial; Enterococcus; Gelatinases; Glycopeptides; Hemolysin Proteins; Hospitalization; Humans; Linezolid; Lipase; Minocycline; Norfloxacin; Oxazolidinones; Phenotype; Poland; Tigecycline; Virulence | 2011 |
In vitro activity of retapamulin against linezolid and methicillin-resistant Staphylococcus aureus isolates.
Topics: Acetamides; Anti-Bacterial Agents; Bacitracin; Bacterial Proteins; Bridged Bicyclo Compounds, Heterocyclic; Diterpenes; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mupirocin; Oxazolidinones; Polymerase Chain Reaction; Staphylococcus aureus | 2011 |
Usefulness of monitoring linezolid trough serum concentration in prolonged treatments.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Drug Monitoring; Female; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Male; Middle Aged; Musculoskeletal Diseases; Orthopedic Procedures; Oxazolidinones; Prosthesis-Related Infections; Treatment Outcome | 2011 |
[Pharmacoeconomic assessment of daptomycin as first-line therapy for bacteraemia and complicated skin and skin structure infections caused by gram-positive pathogens in Spain].
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Cost-Benefit Analysis; Daptomycin; Data Interpretation, Statistical; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Hospitals; Humans; Linezolid; Microbial Sensitivity Tests; Middle Aged; Monte Carlo Method; Oxazolidinones; Salvage Therapy; Skin Diseases, Infectious; Spain; Treatment Failure; Vancomycin; Young Adult | 2011 |
In vitro activity of tedizolid (TR-700) against linezolid-resistant staphylococci.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus; Tetrazoles | 2012 |
Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Benzoxazines; Biological Availability; Crystallography, X-Ray; Drug Design; Drug Resistance, Bacterial; Female; Gram-Positive Bacteria; Linezolid; Male; Mice; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Rats; Rats, Sprague-Dawley; Staphylococcal Infections; Stereoisomerism; Structure-Activity Relationship | 2011 |
Linezolid pharmacokinetics in patients with acute renal failure undergoing continuous venovenous hemodiafiltration.
Topics: Acetamides; Acute Kidney Injury; Aged; Anti-Infective Agents; Critical Illness; Female; Hemodiafiltration; Humans; Linezolid; Listeria monocytogenes; Listeriosis; Male; Meningitis, Pneumococcal; Middle Aged; Oxazolidinones; Shock, Septic | 2012 |
Identification of international circulating lineages of meticillin-resistant Staphylococcus aureus in the north of Spain and their glycopeptide and linezolid susceptibility.
Topics: Acetamides; Cluster Analysis; Glycopeptides; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Epidemiology; Molecular Typing; Oxazolidinones; Spain; Staphylococcal Infections | 2012 |
Time-kill study and synergistic activity of cell-wall inhibitor antibiotics in combination with gentamicin against Enterococcus faecalis and Enterococcus faecium.
Topics: Acetamides; Ampicillin; Anti-Bacterial Agents; Bacterial Proteins; Carbon-Oxygen Ligases; Drug Synergism; Enterococcus faecalis; Enterococcus faecium; Gentamicins; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Teicoplanin; Vancomycin | 2011 |
A severe case of paediatric group A streptococcal osteomyelitis in varicella.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Chickenpox; Female; Humans; Infant; Linezolid; Osteomyelitis; Oxazolidinones; Radiography; Streptococcal Infections; Streptococcus; Ulna; Ultrasonography | 2012 |
Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case report and literature review.
Topics: Acetamides; Anti-Bacterial Agents; Drug Hypersensitivity; Female; Humans; Linezolid; Middle Aged; Myasthenia Gravis; Nocardia; Nocardia Infections; Oxazolidinones | 2012 |
Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations.
Topics: Acetamides; Anti-Bacterial Agents; DNA, Bacterial; Drug Resistance, Bacterial; Genome, Bacterial; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Streptococcus pneumoniae; Transformation, Bacterial | 2011 |
Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Chromosomes, Bacterial; Genetic Loci; Genomic Instability; Humans; Linezolid; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Sequence Data; Mutagenesis, Insertional; Operon; Oxazolidinones; Peptidyl Transferases; Plasmids; Recombination, Genetic; RNA, Ribosomal, 23S; Sequence Deletion; Staphylococcal Infections | 2012 |
Antibiotic modulation of the plasminogen binding ability of viridans group streptococci.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Endocarditis, Bacterial; Fibrinolysin; Gene Expression Regulation, Bacterial; Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Penicillins; Phosphopyruvate Hydratase; Plasminogen; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Streptococcal Infections; Streptococcus mitis; Streptococcus oralis; Streptococcus sanguis; Vancomycin | 2012 |
Sparsomycin-linezolid conjugates can promote ribosomal translocation.
Topics: Acetamides; Anti-Bacterial Agents; Biological Transport; Linezolid; Models, Molecular; Oxazolidinones; Ribosomes; Sparsomycin | 2011 |
Usefulness of linezolid in the treatment of hospital-acquired pneumonia caused by MRSA: a prospective observational study.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Cross Infection; Female; Humans; Japan; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Prospective Studies; Treatment Outcome; Young Adult | 2012 |
Use of linezolid in neonatal and pediatric inpatient facilities--results of a retrospective multicenter survey.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Austria; Bacterial Infections; Child; Child, Preschool; Female; Germany; Hospitals, Pediatric; Humans; Infant; Infant, Newborn; Linezolid; Male; Off-Label Use; Oxazolidinones; Retrospective Studies; Treatment Outcome; Young Adult | 2012 |
Good practice in antibiotic use: what about linezolid in a French university hospital?
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Child; Child, Preschool; Cohort Studies; Data Collection; Drug Resistance, Multiple, Bacterial; Female; France; Hospitals, University; Humans; Infant; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Practice Patterns, Physicians'; Retrospective Studies; Staphylococcal Infections; Treatment Outcome; Young Adult | 2011 |
Simulated antibiotic exposures in an in vitro hollow-fiber infection model influence toxin gene expression and production in community-associated methicillin-resistant Staphylococcus aureus strain MW2.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Cell Culture Techniques; Clindamycin; Community-Acquired Infections; Enzyme-Linked Immunosorbent Assay; Exotoxins; Gene Expression Regulation, Bacterial; Humans; Leukocidins; Leukocytes, Mononuclear; Linezolid; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Models, Biological; Oxazolidinones; Real-Time Polymerase Chain Reaction; Staphylococcal Infections; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin; Virulence Factors | 2012 |
Differential effects of linezolid and ciprofloxacin on toxin production by Bacillus anthracis in an in vitro pharmacodynamic system.
Topics: Acetamides; Anthrax; Anti-Bacterial Agents; Bacillus anthracis; Bacterial Load; Bacterial Toxins; Ciprofloxacin; Diffusion Chambers, Culture; Infusion Pumps; Linezolid; Microbial Sensitivity Tests; Models, Biological; Oxazolidinones; Spores, Bacterial | 2012 |
[Influence of inoculum size on MICs for methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus].
Topics: Acetamides; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacteriological Techniques; Cefazolin; Ciprofloxacin; Dibekacin; Drug Resistance, Bacterial; Linezolid; Meropenem; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Teicoplanin; Thienamycins; Vancomycin | 2011 |
[Case of meningitis caused by group B Streptococcus treated with high dose of meropenem].
Topics: Acetamides; Aged; Anti-Bacterial Agents; Drug Therapy, Combination; Humans; Linezolid; Male; Meningitis, Bacterial; Meropenem; Oxazolidinones; Pulse Therapy, Drug; Serotyping; Streptococcal Infections; Streptococcus agalactiae; Thienamycins; Treatment Outcome; Vancomycin | 2011 |
Vancomycin-resistant Enterococcus bacteremia: an evaluation of treatment with linezolid or daptomycin.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Daptomycin; Enterococcus faecalis; Female; Humans; Immunocompromised Host; Linezolid; Male; Middle Aged; Outcome Assessment, Health Care; Oxazolidinones; Retrospective Studies; United States; Vancomycin; Vancomycin Resistance | 2012 |
Susceptibility to tigecycline and linezolid among gram-positive isolates collected in the United States as part of the tigecycline evaluation and surveillance trial (TEST) between 2004 and 2009.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Streptococcus pneumoniae; Tigecycline; Treatment Outcome; United States; Vancomycin Resistance | 2011 |
Serotonin syndrome-muscle rigidity and confusion in the older adult.
Topics: Acetamides; Age Factors; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Confusion; Drug Interactions; Drug Therapy, Combination; Emergency Service, Hospital; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Linezolid; Muscle Rigidity; Oxazolidinones; Risk Assessment; Serotonin Syndrome; Severity of Illness Index | 2012 |
Nocardia infection in a renal transplant recipient.
Topics: Acetamides; Anti-Infective Agents; Antifungal Agents; Cyclosporine; Drug Therapy, Combination; Epidural Abscess; Female; Glucocorticoids; Humans; Kidney Failure, Chronic; Kidney Transplantation; Laminectomy; Linezolid; Middle Aged; Nocardia Infections; Opportunistic Infections; Oxazolidinones; Prednisone; Trimethoprim, Sulfamethoxazole Drug Combination | 2011 |
[Evaluation of vancomycin, teicoplanin, linezolide and tigecycline susceptibilities of nosocomial methicillin-resistant Staphylococcus strains by E-test].
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Tigecycline; Turkey; Vancomycin | 2011 |
Meningococcemia presenting as acute painful mononeuritis multiplex.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Ceftriaxone; Electrodiagnosis; Electromyography; Female; Fever; Humans; Linezolid; Meningococcal Infections; Mononeuropathies; Neisseria meningitidis; Neural Conduction; Neurologic Examination; Oxazolidinones; Pain; Sepsis; Sural Nerve | 2012 |
Activity of tigecycline and comparators against skin and skin structure pathogens: global results of the Tigecycline evaluation and surveillance trial, 2004-2009.
Topics: Acetamides; Acinetobacter baumannii; Carbapenems; Drug Evaluation; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Humans; Klebsiella pneumoniae; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Skin; Skin Diseases, Bacterial; Tigecycline; Vancomycin | 2012 |
Effectiveness of ciprofloxacin or linezolid in combination with rifampicin against Enterococcus faecalis in biofilms.
Topics: Acetamides; Anti-Bacterial Agents; Biofilms; Ciprofloxacin; Colony Count, Microbial; Enterococcus faecalis; Humans; Linezolid; Microbial Sensitivity Tests; Microbial Viability; Oxazolidinones; Rifampin | 2012 |
Efficacy and safety of linezolid in the treatment of extensively drug-resistant tuberculosis.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Drug Monitoring; Extensively Drug-Resistant Tuberculosis; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Radiography, Thoracic; Sputum; Tomography, X-Ray Computed; Treatment Outcome | 2011 |
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina with a combination of linezolid, moxifloxacin and thioridazine.
Topics: Acetamides; Adult; Antitubercular Agents; Argentina; Aza Compounds; Compassionate Use Trials; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuberculosis; Female; Fluoroquinolones; Humans; Linezolid; Male; Middle Aged; Moxifloxacin; Mycobacterium tuberculosis; Oxazolidinones; Quinolines; Retrospective Studies; Thioridazine; Treatment Outcome; Tuberculosis, Pulmonary | 2012 |
Comparison of serotonin toxicity with concomitant use of either linezolid or comparators and serotonergic agents: an analysis of Phase III and IV randomized clinical trial data.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Child, Preschool; Clinical Trials, Phase III as Topic; Clinical Trials, Phase IV as Topic; Databases, Factual; Drug Interactions; Drug Therapy, Combination; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Serotonin; Serotonin Agents | 2012 |
[Antibiotic susceptibility of isolates from blood of patients in intensive care units of emergency medical service].
Topics: Acetamides; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Candida; Cross Infection; Drug Resistance, Microbial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Imipenem; Infection Control; Intensive Care Units; Linezolid; Meropenem; Moscow; Oxazolidinones; Sepsis; Thienamycins; Vancomycin | 2011 |
[Antibiotic resistance dynamics and isolation rate of staphylococci and enterococci from patients of reconstructive surgery units].
Topics: Acetamides; Amoxicillin; Anti-Bacterial Agents; Cefoxitin; Cross Infection; Drug Resistance, Microbial; Enterococcus; Fluoroquinolones; Fusidic Acid; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Moscow; Oxacillin; Oxazolidinones; Rifampin; Surgery, Plastic; Vancomycin | 2011 |
an in vitro study comparing the intracanal effectiveness of calcium hydroxide- and linezolid-based medicaments against Enterococcus faecalis.
Topics: Acetamides; Anti-Infective Agents; Bacterial Load; Bicuspid; Calcium Hydroxide; Dental Pulp Cavity; Dentin; Drug Combinations; Enterococcus faecalis; Humans; Linezolid; Materials Testing; Microscopy, Electron, Scanning; Oxazolidinones; Root Canal Filling Materials; Root Canal Irrigants; Root Canal Preparation; Silicones; Time Factors | 2012 |
Impact of spores on the comparative efficacies of five antibiotics for treatment of Bacillus anthracis in an in vitro hollow fiber pharmacodynamic model.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Bacillus anthracis; Ciprofloxacin; Doxycycline; Fluoroquinolones; Linezolid; Meropenem; Microbial Sensitivity Tests; Microbial Viability; Models, Biological; Moxifloxacin; Oxazolidinones; Predictive Value of Tests; Quinolines; Spores, Bacterial; Thienamycins; Viral Load | 2012 |
Pneumonia and bacteremia due to Kytococcus schroeteri.
Topics: Acetamides; Actinomycetales; Actinomycetales Infections; Adult; Anti-Bacterial Agents; Bacteremia; Female; Humans; Immunocompromised Host; Linezolid; Oxazolidinones; Pneumonia, Bacterial; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination | 2012 |
[Evaluation of the mycobacterium efficacy of linezolid in vitro].
Topics: Acetamides; Antitubercular Agents; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones | 2011 |
A comparative evaluation of adverse platelet outcomes among Veterans' Affairs patients receiving linezolid or vancomycin.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Blood Platelets; Cohort Studies; Humans; Incidence; Linezolid; Male; Middle Aged; New York; Oxazolidinones; Thrombocytopenia; Treatment Outcome; Vancomycin | 2012 |
Vancomycin for methicillin-resistant Staphylococcus aureus pneumonia: the good, the bad, and the ugly.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Pneumonia, Ventilator-Associated; Vancomycin | 2012 |
Dissemination of the linezolid-resistant Staphylococcus epidermidis clone ST2 exhibiting the G2576T mutation in the 23S rRNA gene in a tertiary-care hospital, Brazil.
Topics: Acetamides; Anti-Bacterial Agents; Brazil; Cross Infection; Disease Outbreaks; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Hospitals; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Epidemiology; Molecular Typing; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus epidermidis | 2012 |
Enhanced activity of linezolid against Staphylococcus aureus in cerebrospinal fluid.
Topics: Acetamides; Anti-Bacterial Agents; Cerebrospinal Fluid; Humans; Linezolid; Microbial Sensitivity Tests; Microbial Viability; Oxazolidinones; Staphylococcus aureus; Staphylococcus epidermidis | 2012 |
Transferable multidrug resistance plasmid carrying cfr associated with tet(L), ant(4')-Ia, and dfrK genes from a clinical methicillin-resistant Staphylococcus aureus ST125 strain.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Conjugation, Genetic; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Linezolid; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Sequence Data; Nucleotidyltransferases; Oxazolidinones; Plasmids; Polymerase Chain Reaction; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Infections; Spain | 2012 |
Painful polyneuropathy secondary to prolonged treatment with linezolid: presentation of a case.
Topics: Acetamides; Anti-Infective Agents; Ethambutol; Female; Humans; Linezolid; Oxazolidinones; Polyneuropathies; Smoking; Tuberculosis, Pulmonary; Young Adult | 2012 |
Antibiotic treatment against methicillin-resistant Staphylococcus aureus hospital- and ventilator-acquired pneumonia: a step forward but the battle continues.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal | 2012 |
Evaluation of the pharmacokinetics of linezolid in an obese Japanese patient.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Humans; Japan; Linezolid; Lung Diseases; Male; Methicillin-Resistant Staphylococcus aureus; Obesity; Oxazolidinones; Staphylococcal Infections | 2012 |
Virulence-suppressing effects of linezolid on methicillin-resistant Staphylococcus aureus: possible contribution to early defervescence.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-6; Linezolid; Lung; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Oxazolidinones; Pyrogens; Sepsis; Staphylococcal Infections; Tumor Necrosis Factor-alpha; Virulence; Virulence Factors | 2012 |
Clonal dissemination of linezolid-resistant Staphylococcus haemolyticus exhibiting the G2576T mutation in the 23S rRNA gene in a tertiary care hospital in Brazil.
Topics: Acetamides; Anti-Bacterial Agents; Brazil; Catheter-Related Infections; Catheters; Cross Infection; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus haemolyticus | 2012 |
Osteomyelitits due to linezolid-resistant Staphylococcus epidermidis.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Osteomyelitis; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis | 2012 |
Comparative in vivo efficacies of epithelial lining fluid exposures of tedizolid, linezolid, and vancomycin for methicillin-resistant Staphylococcus aureus in a mouse pneumonia model.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Disease Models, Animal; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Oxazolidinones; Pneumonia, Staphylococcal; Survival Rate; Tetrazoles; Vancomycin | 2012 |
Risk factors associated with linezolid-nonsusceptible enterococcal infections.
Topics: Acetamides; Anti-Bacterial Agents; Case-Control Studies; Drug Resistance, Bacterial; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Risk Factors | 2012 |
Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Ceftriaxone; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Structure-Activity Relationship | 2012 |
Pharmacokinetic-pharmacodynamic evaluation of daptomycin, tigecycline, and linezolid versus vancomycin for the treatment of MRSA infections in four western European countries.
Topics: Acetamides; Anti-Bacterial Agents; Belgium; Daptomycin; Ireland; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Spain; Staphylococcal Infections; Tigecycline; United Kingdom; Vancomycin | 2012 |
rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strains.
Topics: Acetamides; Antitubercular Agents; DNA, Bacterial; Drug Resistance, Bacterial; High-Throughput Nucleotide Sequencing; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Oxazolidinones; Ribosomal Protein L3; Ribosomal Proteins | 2012 |
Successful long-term treatment of cerebral nocardiosis with unexpectedly low doses of linezolid in an immunocompromised patient receiving complex polytherapy.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Brain Abscess; Female; Humans; Immunocompromised Host; Linezolid; Nocardia Infections; Oxazolidinones | 2012 |
Determination of the permeability characteristics of two sulfenamide prodrugs of linezolid across Caco-2 cells.
Topics: Acetamides; Caco-2 Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Kinetics; Linezolid; Models, Biological; Oxazolidinones; Permeability; Prodrugs; Sulfamerazine | 2012 |
The safety and efficacy of linezolid and daptomycin as an additive in Optisol-GS against methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Chondroitin Sulfates; Colony Count, Microbial; Complex Mixtures; Cornea; Culture Media, Serum-Free; Daptomycin; Dextrans; Drug Stability; Drug Therapy, Combination; Gentamicins; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Organ Preservation; Organ Preservation Solutions; Oxazolidinones; Pilot Projects; Staphylococcal Infections; Treatment Outcome | 2012 |
On linezolid efficacy and tolerability.
Topics: Acetamides; Adult; Antitubercular Agents; Cohort Studies; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Treatment Outcome | 2012 |
Decreased serum linezolid concentrations in two patients receiving linezolid and rifampicin due to bone infections.
Topics: Acetamides; Adult; Aged, 80 and over; Anti-Bacterial Agents; Drug Interactions; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Osteomyelitis; Oxazolidinones; Prosthesis-Related Infections; Rifampin; Serum; Staphylococcal Infections | 2012 |
Genome-wide expression profiling of the response to linezolid in Mycobacterium tuberculosis.
Topics: Acetamides; Antitubercular Agents; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Humans; Linezolid; Microarray Analysis; Mycobacterium tuberculosis; Oxazolidinones; Real-Time Polymerase Chain Reaction | 2012 |
[Clinical analysis of linezolid in treatment of infection with methicillin--resistant Staphylococcus in 14 neurosurgical patients].
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Central Nervous System Infections; Female; Humans; Linezolid; Male; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Neurosurgical Procedures; Oxazolidinones; Postoperative Period; Retrospective Studies; Staphylococcal Infections; Young Adult | 2012 |
Daily 300 mg dose of linezolid for multidrug-resistant and extensively drug-resistant tuberculosis: updated analysis of 51 patients.
Topics: Acetamides; Adult; Antitubercular Agents; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2012 |
Development of novel molecularly imprinted solid-phase microextraction fibers and their application for the determination of antibiotic drugs in biological samples by SPME-LC/MS(n).
Topics: Acetamides; Amoxicillin; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Daptomycin; Humans; Linezolid; Mass Spectrometry; Molecular Imprinting; Oxazolidinones; Polymers; Pyrroles; Sensitivity and Specificity; Solid Phase Microextraction; Thiophenes | 2012 |
The impact of an infectious diseases specialist-directed computerized physician order entry antimicrobial stewardship program targeting linezolid use.
Topics: Acetamides; Anti-Infective Agents; Drug Utilization Review; Humans; Linezolid; Medical Order Entry Systems; Oxazolidinones; Program Evaluation | 2012 |
Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitro.
Topics: Acetamides; Biofilms; Cerebrospinal Fluid Shunts; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Staphylococcus epidermidis; Vancomycin | 2012 |
Pharmacokinetics and pulmonary disposition of tedizolid and linezolid in a murine pneumonia model under variable conditions.
Topics: Acetamides; Animals; Anti-Infective Agents; Female; Linezolid; Mice; Mice, Inbred BALB C; Oxazolidinones; Pneumonia; Tetrazoles | 2012 |
Linezolid as rescue treatment for left-sided infective endocarditis: an observational, retrospective, multicenter study.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Denmark; Drug Tolerance; Endocarditis, Bacterial; Enterococcus; Female; Follow-Up Studies; Hospital Mortality; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Retrospective Studies; Streptococcus; Survival Analysis; Tertiary Care Centers; Treatment Outcome | 2012 |
Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism.
Topics: Absorption; Acetamides; Circular Dichroism; Crystallization; Ketones; Linezolid; Oxazolidinones; Quantum Theory | 2012 |
Direct analysis of bacterial viability in endotracheal tube biofilm from a pig model of methicillin-resistant Staphylococcus aureus pneumonia following antimicrobial therapy.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Biofilms; Disease Models, Animal; Equipment and Supplies; Intubation, Intratracheal; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Viability; Microscopy, Confocal; Oxazolidinones; Placebos; Pneumonia, Staphylococcal; Spain; Staining and Labeling; Swine; Vancomycin | 2012 |
Potential protective role of linezolid against Clostridium difficile infection.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Cohort Studies; Cross Infection; Diarrhea; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pneumonia, Ventilator-Associated; Retrospective Studies; Spain; Treatment Outcome | 2012 |
Scaling adult doses of antifungal and antibacterial agents to children.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Child; Drug Administration Schedule; Echinocandins; Female; Humans; Infant; Linezolid; Lipopeptides; Male; Models, Theoretical; Oxazolidinones; Young Adult | 2012 |
Probable drug-drug interaction leading to serotonin syndrome in a patient treated with concomitant buspirone and linezolid in the setting of therapeutic hypothermia.
Topics: Acetamides; Adult; Buspirone; Drug Interactions; Drug Therapy, Combination; Humans; Hypothermia; Linezolid; Male; Oxazolidinones; Serotonin Syndrome | 2012 |
Safety and efficacy of linezolid in 16 infants and children in Japan.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Drug Resistance, Multiple, Bacterial; Female; Humans; Infant; Infant, Newborn; Japan; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Surgical Wound Infection | 2012 |
Evaluation of standard- and high-dose daptomycin versus linezolid against vancomycin-resistant Enterococcus isolates in an in vitro pharmacokinetic/pharmacodynamic model with simulated endocardial vegetations.
Topics: Acetamides; Daptomycin; Endocarditis, Bacterial; Enterococcus; Enterococcus faecalis; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Vancomycin | 2012 |
Linezolid-induced pure red cell aplasia in a patient with Staphylococcus epidermidis infection after allogeneic stem cell transplantation.
Topics: Acetamides; Anti-Infective Agents; Bacteremia; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Red-Cell Aplasia, Pure; Staphylococcal Infections; Staphylococcus epidermidis; Stem Cell Transplantation; Transplantation, Homologous | 2012 |
[Activity of vancomycin, teicoplanin and linezolid in methicillin resistant coagulase-negative Staphylococci isolates from paediatric blood cultures].
Topics: Acetamides; Anti-Bacterial Agents; Child; Child, Preschool; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Female; Humans; Infant; Infant, Newborn; Linezolid; Male; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Polymerase Chain Reaction; Staphylococcal Infections; Staphylococcus; Staphylococcus epidermidis; Staphylococcus hominis; Teicoplanin; Vancomycin | 2012 |
[Analysis of treatments used in infections caused by gram-positive multiresistant cocci in critically ill patients admitted to the ICU].
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Cohort Studies; Critical Care; Critical Illness; Daptomycin; Drug Prescriptions; Drug Resistance, Multiple, Bacterial; Drug Utilization; Female; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Intensive Care Units; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Teicoplanin; Vancomycin | 2012 |
Trends in susceptibility of vancomycin-resistant Enterococcus faecium to tigecycline, daptomycin, and linezolid and molecular epidemiology of the isolates: results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) study, 2006 to 2010.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecium; Linezolid; Microbial Sensitivity Tests; Minocycline; Molecular Epidemiology; Oxazolidinones; Taiwan; Tigecycline; Vancomycin Resistance | 2012 |
Transferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalis.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Humans; Linezolid; Molecular Sequence Data; Oxazolidinones; Plasmids | 2012 |
Limited detectability of linezolid-resistant Staphylococcus aureus by the Etest method and its improvement using enriched media.
Topics: Acetamides; Anti-Bacterial Agents; Culture Media; Drug Resistance, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Sensitivity and Specificity | 2012 |
[Linezolid-associated optic neuropathy?].
Topics: Acetamides; Adult; Anti-Arrhythmia Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Blindness; Female; Humans; Linezolid; Optic Nerve Diseases; Oxazolidinones | 2012 |
Front-loaded linezolid regimens result in increased killing and suppression of the accessory gene regulator system of Staphylococcus aureus.
Topics: Acetamides; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Monte Carlo Method; Oxazolidinones; Real-Time Polymerase Chain Reaction; Staphylococcus aureus | 2012 |
Intensive care unit dissemination of multiple clones of linezolid-resistant Enterococcus faecalis and Enterococcus faecium.
Topics: Acetamides; Anti-Bacterial Agents; Cluster Analysis; Cross Infection; Disease Outbreaks; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecalis; Enterococcus faecium; Genotype; Gram-Positive Bacterial Infections; Greece; Hospitals, University; Humans; Intensive Care Units; Linezolid; Molecular Epidemiology; Molecular Typing; Oxazolidinones; Polymerase Chain Reaction; RNA, Ribosomal, 23S; Sequence Analysis, DNA | 2012 |
Efficacy of linezolid versus a pharmacodynamically optimized vancomycin therapy in an experimental pneumonia model caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Load; Disease Models, Animal; Female; Linezolid; Lung; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred C57BL; Oxazolidinones; Pneumonia, Staphylococcal; Treatment Outcome; Vancomycin | 2012 |
Probable linezolid-induced thrombocytopenia in a patient with vancomycin-resistant enterococci.
Topics: Acetamides; Aged; Anti-Infective Agents; Blood Platelets; Enterococcus; Humans; Linezolid; Male; Oxazolidinones; Platelet Count; Risk Factors; Thrombocytopenia; Vancomycin; Vancomycin Resistance; White People | 2012 |
Antimicrobial susceptibility among E. faecalis and E. faecium from France, Germany, Italy, Spain and the UK (T.E.S.T. Surveillance Study, 2004-2009).
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; France; Germany; Humans; Italy; Linezolid; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Spain; Tigecycline | 2012 |
Bactericidal activity of ACH-702 against nondividing and biofilm Staphylococci.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Biofilms; Fluoroquinolones; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Moxifloxacin; Oxazolidinones; Quinolines; Quinolones; Rifampin; Staphylococcus; Thiazoles; Vancomycin | 2012 |
Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacterial Infections; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Plasma; Retrospective Studies; Rifampin; Treatment Outcome | 2012 |
High-resolution melting analysis for rapid detection of linezolid resistance (mediated by G2576T mutation) in Staphylococcus epidermidis.
Topics: Acetamides; Anti-Bacterial Agents; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Point Mutation; RNA, Bacterial; RNA, Ribosomal, 23S; Sensitivity and Specificity; Staphylococcus epidermidis; Transition Temperature | 2012 |
Elimination of teicoplanin by adsorption to the filter membrane during haemodiafiltration: screening experiments for linezolid, teicoplanin and vancomycin followed by in vitro haemodiafiltration models for teicoplanin.
Topics: Acetamides; Adsorption; Albumins; Algorithms; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Filtration; Hemodiafiltration; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Models, Biological; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Vancomycin | 2012 |
Emergence of vancomycin-resistant Enterococcus bloodstream infections in southern Taiwan.
Topics: Acetamides; Aged; Aged, 80 and over; Analysis of Variance; Anti-Bacterial Agents; Bacteremia; Daptomycin; Enterococcus; Female; Gram-Positive Bacterial Infections; Hospitals, University; Humans; Incidence; Linezolid; Male; Middle Aged; Oxazolidinones; Proportional Hazards Models; Retrospective Studies; Risk Factors; Taiwan; Vancomycin; Vancomycin Resistance | 2012 |
Resistance to linezolid in a methicillin-susceptible Staphylococcus aureus clinical isolate without previous exposure to oxazolidinones.
Topics: Acetamides; Aged, 80 and over; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Humans; Linezolid; Methicillin; Microbial Sensitivity Tests; Outpatients; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus; Surgical Wound Infection | 2012 |
In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Multiple, Bacterial; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oligopeptides; Oxazolidinones; Vancomycin; Vancomycin Resistance | 2012 |
Synthesis, spectral and antibacterial sudies of copper(II) tetraaza macrocyclic complexes.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Cefaclor; Copper; Gram-Negative Bacteria; Gram-Positive Bacteria; Linezolid; Macrocyclic Compounds; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazolidinones; Spectrophotometry, Infrared | 2012 |
Linezolid limits burden of methicillin-resistant Staphylococcus aureus in biofilm of tracheal tubes.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Biofilms; Intubation, Intratracheal; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microscopy, Electron, Scanning; Oxazolidinones; Pneumonia, Staphylococcal; Pneumonia, Ventilator-Associated; Swine; Vancomycin | 2012 |
In vitro activity of linezolid against clinical isolates of Mycobacterium tuberculosis, including multidrug-resistant and extensively drug-resistant strains from Beijing, China.
Topics: Acetamides; Antitubercular Agents; China; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2012 |
Linezolid in the treatment of MDR-TB: a retrospective clinical study.
Topics: Acetamides; Adult; Aged; Antitubercular Agents; China; Dose-Response Relationship, Drug; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Retrospective Studies; Sputum; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Young Adult | 2012 |
[Linezolid, coagulase-negative Staphylococcus and the problem of resistances].
Topics: Acetamides; Aged; Coagulase; Cross Infection; Drug Resistance, Multiple, Bacterial; Female; Hospital Departments; Hospital Mortality; Humans; Length of Stay; Linezolid; Male; Middle Aged; Oxazolidinones; Spain; Staphylococcal Infections; Staphylococcus | 2012 |
Efficacy of intravitreal administrations of linezolid in an experimental model of S. aureus-related endophthalmitis.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Disease Models, Animal; Electroretinography; Endophthalmitis; Female; Intravitreal Injections; Linezolid; Oxazolidinones; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin; Vitreous Body | 2012 |
Impetigo presenting as an acute necrotizing swelling of the lower lip in an adult patient.
Topics: Acetamides; Acute Disease; Adult; Anti-Infective Agents; Diagnosis, Differential; Drug Combinations; Humans; Impetigo; Injections, Intravenous; Linezolid; Lip Diseases; Male; Metronidazole; Necrosis; Oxazolidinones | 2012 |
Pharmacodynamics of early, high-dose linezolid against vancomycin-resistant enterococci with elevated MICs and pre-existing genetic mutations.
Topics: Acetamides; Anti-Bacterial Agents; Colony Count, Microbial; Enterococcus faecalis; Humans; Linezolid; Microbial Sensitivity Tests; Microbial Viability; Models, Theoretical; Mutation; Oxazolidinones; Time Factors; Vancomycin; Vancomycin Resistance | 2012 |
Comparative efficacies of human simulated exposures of tedizolid and linezolid against Staphylococcus aureus in the murine thigh infection model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Load; Female; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Skin Infections; Tetrazoles; Thigh | 2012 |
Molecular epidemiology of Staphylococcus epidermidis clinical isolates from U.S. hospitals.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Typing Techniques; Child, Preschool; Drug Resistance, Multiple, Bacterial; Female; Hospitals; Humans; Infant; Linezolid; Male; Middle Aged; Multigene Family; Multilocus Sequence Typing; Mutation; Oxazolidinones; Phylogeny; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus epidermidis; United States | 2012 |
Treatment of methicillin-resistant Staphylococcus aureus ventilator-associated pneumonia with high-dose vancomycin or linezolid.
Topics: Acetamides; Adult; Aged; Cohort Studies; Critical Illness; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injury Severity Score; Intensive Care Units; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Pneumonia, Ventilator-Associated; Respiration, Artificial; Retrospective Studies; Risk Assessment; Severity of Illness Index; Staphylococcal Infections; Survival Rate; Trauma Centers; Treatment Outcome; Vancomycin; Wounds and Injuries | 2012 |
LEADER surveillance program results for 2010: an activity and spectrum analysis of linezolid using 6801 clinical isolates from the United States (61 medical centers).
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus; Streptococcal Infections; Streptococcus; United States | 2012 |
Effect of linezolid on the 50% lethal dose and 50% protective dose in treatment of infections by Gram-negative pathogens in naive and immunosuppressed mice and on the efficacy of ciprofloxacin in an acute murine model of septicemia.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Ciprofloxacin; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Female; Immunocompromised Host; Klebsiella Infections; Klebsiella pneumoniae; Lethal Dose 50; Linezolid; Mice; Models, Animal; Oxazolidinones; Pseudomonas aeruginosa; Pseudomonas Infections; Sepsis; Survival Rate; Treatment Outcome | 2012 |
Activity of tedizolid phosphate (TR-701) in murine models of infection with penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Culture Media; Drug Administration Schedule; Female; Linezolid; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Microbial Sensitivity Tests; Models, Animal; Organophosphates; Oxazoles; Oxazolidinones; Penicillin Resistance; Penicillins; Pneumonia, Pneumococcal; Streptococcus pneumoniae; Survival Rate | 2012 |
[Enterococcus faecalis meningitis after spinal anesthesia successfully managed with linezolid].
Topics: Acetamides; Anesthesia, Spinal; Anti-Infective Agents; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Oxazolidinones; Remission Induction; Young Adult | 2012 |
Mitochondrial loss indicates early axonal damage in small fiber neuropathies.
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Axons; Biopsy; Early Diagnosis; Electron Transport Complex IV; Female; Humans; Linezolid; Male; Microscopy, Confocal; Middle Aged; Mitochondria; Nerve Fibers; Oxazolidinones; Peripheral Nervous System Diseases; Skin | 2012 |
Linezolid for multidrug-resistant tuberculosis.
Topics: Acetamides; Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Oxazolidinones; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2012 |
Risk factors and outcomes associated with vancomycin-resistant Enterococcus infections with reduced susceptibilities to linezolid.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Case-Control Studies; Drug Resistance, Bacterial; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Retrospective Studies; Risk Factors; Treatment Outcome; Vancomycin; Young Adult | 2012 |
Negative impact of linezolid on human neutrophil functions in vitro.
Topics: Acetamides; Anti-Infective Agents; Catheter-Related Infections; Chemotaxis; Escherichia coli; Flow Cytometry; Gram-Negative Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Neutrophils; Oxazolidinones; Phagocytosis; Pseudomonas aeruginosa; Staphylococcus aureus | 2012 |
Clinical efficacy of oral linezolid compared with intravenous vancomycin for the treatment of methicillin-resistant Staphylococcus aureus-complicated skin and soft tissue infections: a retrospective, propensity score-matched, case-control analysis.
Topics: Acetamides; Administration, Oral; Adult; Aged; Anti-Bacterial Agents; Clinical Trials, Phase IV as Topic; Female; Humans; Infusions, Intravenous; Linezolid; Logistic Models; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Multicenter Studies as Topic; Odds Ratio; Oxazolidinones; Propensity Score; Randomized Controlled Trials as Topic; Retrospective Studies; Soft Tissue Infections; Staphylococcal Skin Infections; Treatment Outcome; Vancomycin | 2012 |
Usefulness of SBA-15 mesoporous ceramics as a delivery system for vancomycin, rifampicin and linezolid: a preliminary report.
Topics: Acetamides; Anti-Bacterial Agents; Bacillus subtilis; Biological Assay; Ceramics; Chromatography, High Pressure Liquid; Drug Carriers; Drug Delivery Systems; Linezolid; Micrococcaceae; Oxazolidinones; Rifampin; Silicon Dioxide; Vancomycin | 2012 |
Activity of linezolid and high-dose daptomycin, alone or in combination, in an in vitro model of Staphylococcus aureus biofilm.
Topics: Acetamides; Anti-Bacterial Agents; Biofilms; Daptomycin; Drug Interactions; Humans; In Vitro Techniques; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections | 2012 |
Co-infection by two linezolid-resistant coagulase-negative staphylococci with two different resistance determinants.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Coagulase; Coinfection; Drug Resistance, Bacterial; Humans; Italy; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus | 2012 |
Surgical site infection prophylaxis strategies for cardiothoracic surgery: a decision-analytic model.
Topics: Acetamides; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacterial Infections; Cefuroxime; Humans; Incidence; Linezolid; Oxazolidinones; Preoperative Care; Surgical Wound Infection; Survival Analysis; Thoracic Surgical Procedures; United States; Vancomycin | 2012 |
Linezolid is superior to vancomycin in experimental pneumonia caused by Superantigen-Producing staphylococcus aureus in HLA class II transgenic mice.
Topics: Acetamides; Animals; Linezolid; Mice; Mice, Inbred BALB C; Mice, Transgenic; Oxazolidinones; Pneumonia, Bacterial; Staphylococcal Infections; Staphylococcus aureus; Superantigens; Vancomycin | 2012 |
Linezolid use in ventilator-associated pneumonia: look at the body weight of your patient!
Topics: Acetamides; Anti-Infective Agents; Area Under Curve; Body Weight; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Obesity; Oxazolidinones; Pneumonia, Ventilator-Associated; Staphylococcal Infections | 2012 |
A mixed infection of Leuconostoc lactis and vancomycin-resistant Enterococcus in a liver transplant recipient.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus; Gram-Positive Bacterial Infections; Humans; Leuconostoc; Linezolid; Liver Transplantation; Male; Middle Aged; Oxazolidinones; Sepsis; Vancomycin Resistance | 2012 |
A dual outbreak of bloodstream infections with linezolid-resistant Staphylococcus epidermidis and Staphylococcus pettenkoferi in a liver Intensive Care Unit.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Cross Infection; Disease Outbreaks; DNA, Bacterial; Drug Resistance, Bacterial; Female; Humans; Intensive Care Units; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Sequence Data; Oxazolidinones; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus | 2012 |
Linezolid-resistant clinical isolates of meticillin-resistant coagulase-negative staphylococci and Enterococcus faecium from China.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; China; Coagulase; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus | 2012 |
Cost avoidance using linezolid for methicillin-resistant Staphylococcus aureus infections in a specialist diabetes foot clinic.
Topics: Acetamides; Diabetic Foot; Drug Utilization; Health Care Costs; Humans; Length of Stay; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Skin Infections; Staphylococcus aureus; United Kingdom | 2012 |
Empiric antibiotics pending bronchoalveolar lavage data in patients without pneumonia significantly alters the flora, but not the resistance profile, if a subsequent pneumonia develops.
Topics: Acetamides; Anti-Bacterial Agents; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cefepime; Cephalosporins; Drug Resistance, Bacterial; Drug Therapy, Combination; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Penicillanic Acid; Piperacillin; Pneumonia, Ventilator-Associated; Retrospective Studies; Tazobactam; Treatment Outcome; Vancomycin; Wounds and Injuries | 2013 |
Linezolid-associated thrombocytopenia.
Topics: Acetamides; Aged; Anti-Infective Agents; Drug Monitoring; Humans; Kidney Failure, Chronic; Linezolid; Male; Oxazolidinones; Platelet Count; Risk Factors; Thrombocytopenia | 2012 |
A delivery system of linezolid to enhance the MRSA osteomyelitis prognosis: in vivo experimental assessment.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Apatites; Bone and Bones; Bone Marrow; Colony Count, Microbial; Disease Models, Animal; Drug Delivery Systems; Female; Linezolid; Methicillin-Resistant Staphylococcus aureus; Osteomyelitis; Oxazolidinones; Rabbits; Staphylococcal Infections; Treatment Outcome | 2013 |
Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis.
Topics: Acetamides; Amino Acid Sequence; Animals; Antitubercular Agents; Clofazimine; Diarylquinolines; Disease Models, Animal; Drug Discovery; Drugs, Investigational; Female; Genetic Engineering; Latent Tuberculosis; Linezolid; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Sequence Data; Mycobacterium tuberculosis; Oxazines; Oxazolidinones; Quinolines; Rifampin; Streptomycin; Structure-Activity Relationship; Xanthenes | 2012 |
Dried blood spot analysis for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis.
Topics: Acetamides; Adult; Antitubercular Agents; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Drug Monitoring; Female; Humans; Linezolid; Male; Mycobacterium tuberculosis; Oxazolidinones; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tuberculosis, Multidrug-Resistant | 2012 |
Vancomycin versus linezolid in the treatment of methicillin-resistant Staphylococcus aureus nosocomial pneumonia: implications of the ZEPHyR trial.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Vancomycin | 2012 |
[Evaluation of antibiotic susceptibilities and VISA-VRSA rates among MRSA strains isolated from hospitalized patients in intensive care units of hospitals in seven provinces of Turkey].
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Humans; Intensive Care Units; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Tigecycline; Turkey; Vancomycin; Vancomycin Resistance; Virginiamycin | 2012 |
[In vitro activity of linezolid and dalbavancin against vancomycin-resistant enterococci].
Topics: Acetamides; Anti-Bacterial Agents; Enterococcaceae; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Rectum; Teicoplanin; Turkey; Vancomycin Resistance | 2012 |
[Linezolid-resistant Enterococcus faecium: the first G2576T mutation in Turkey].
Topics: Acetamides; Aged; Anti-Infective Agents; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Mutation; Oxazolidinones; Pressure Ulcer; Turkey; Vancomycin Resistance | 2012 |
Comparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Area Under Curve; Blood Proteins; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Linezolid; Lung; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Neutropenia; Organophosphates; Oxazoles; Oxazolidinones; Pneumonia, Staphylococcal; Prodrugs; Protein Binding; Staphylococcus aureus | 2012 |
Bioresolution of (R)-glycidyl azide by Aspergillus niger ZJUTZQ208: a new and concise synthon for chiral vicinal amino alcohols.
Topics: Acetamides; Amino Alcohols; Anti-Bacterial Agents; Aspergillus niger; Biotransformation; Cluster Analysis; DNA, Fungal; DNA, Ribosomal; Epoxide Hydrolases; Genes, rRNA; Hydrogen-Ion Concentration; Linezolid; Models, Molecular; Molecular Dynamics Simulation; Molecular Sequence Data; Oxazolidinones; Phylogeny; Polymers; RNA, Fungal; RNA, Ribosomal, 18S; Sequence Analysis, DNA; Time Factors | 2013 |
A reduced linezolid dosage maintains favorable efficacy with minimal hematologic toxicity in a methicillin-resistant Staphylococcus aureus-infected patient with renal insufficiency.
Topics: Acetamides; Aged, 80 and over; Anti-Infective Agents; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Platelet Count; Renal Insufficiency; Staphylococcal Infections | 2013 |
Vancomycin-resistant Enterococcus faecium meningitis in adults: case series and review of the literature.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Daptomycin; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Meningitis, Bacterial; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Retrospective Studies; Vancomycin Resistance; Virginiamycin | 2013 |
[Microbiological monitoring in therapy of patients with iatrogenic esophageotracheal fistula].
Topics: Acetamides; Anti-Bacterial Agents; Candida; Cefepime; Cephalosporins; Ciprofloxacin; Drug Resistance, Microbial; Enterobacteriaceae; Follow-Up Studies; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Iatrogenic Disease; Imipenem; Intubation, Intratracheal; Linezolid; Microbial Sensitivity Tests; Monitoring, Physiologic; Oxazolidinones; Polymyxin B; Pseudomonas aeruginosa; Respiratory Tract Infections; Staphylococcus aureus; Staphylococcus epidermidis; Tracheoesophageal Fistula; Vancomycin | 2012 |
Efficacy and safety of meropenem-clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB.
Topics: Acetamides; Adult; Antitubercular Agents; Case-Control Studies; Clavulanic Acid; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Female; Humans; Linezolid; Male; Meropenem; Middle Aged; Oxazolidinones; Thienamycins; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2013 |
Adsorption of various antimicrobial agents to endotoxin removal polymyxin-B immobilized fiber (Toraymyxin®). Part 2: Adsorption of two drugs to Toraymyxin PMX-20R cartridges.
Topics: Acetamides; Adsorption; Anti-Bacterial Agents; Anti-Infective Agents; Chromatography, High Pressure Liquid; Ciprofloxacin; Endotoxins; Humans; Kinetics; Linezolid; Oxazolidinones; Polymyxin B; Renal Dialysis; Serum | 2013 |
Corynebacterium minutissimum infecting pseudomeningocele: a rare case.
Topics: Acetamides; Anti-Bacterial Agents; Cerebrospinal Fluid; Corynebacterium; Corynebacterium Infections; Female; Humans; Linezolid; Meningioma; Middle Aged; Oxazolidinones; Surgical Wound Infection; Treatment Outcome | 2014 |
Anxiolytic-like effect of linezolid in experimental mouse models of anxiety.
Topics: Acetamides; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Emotions; Linezolid; Male; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Oxazolidinones | 2013 |
Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children.
Topics: Acetamides; Adolescent; Age Factors; Anti-HIV Agents; Antitubercular Agents; Child; Child, Preschool; Coinfection; Cost Savings; Drug Costs; Drug Interactions; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Female; HIV Infections; Humans; Infant; Linezolid; Male; Mycobacterium tuberculosis; Oxazolidinones; Retrospective Studies; South Africa; Sputum; Time Factors; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2012 |
Long-term treatment with linezolid in a patient with osteomyelitis undergoing hemodialysis.
Topics: Acetamides; Amputation Stumps; Anti-Bacterial Agents; Drug Monitoring; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Kidney Failure, Chronic; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones; Renal Dialysis; Time Factors; Treatment Outcome | 2012 |
Linezolid resistant Staphylococcus haemolyticus: first case report from India.
Topics: Acetamides; Anti-Bacterial Agents; Clindamycin; Drug Resistance, Multiple, Bacterial; Hip Fractures; Humans; India; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Rifampin; Staphylococcal Infections; Staphylococcus haemolyticus; Surgical Wound Infection; Treatment Outcome | 2012 |
[Characterization of methicillin- and linezolid-resistant Staphylococcus epidermidis and S. haemolyticus strains in a Spanish hospital].
Topics: Acetamides; Adult; Aged; Anti-Infective Agents; Drug Resistance, Bacterial; Female; Genotype; Hospitals; Humans; Linezolid; Male; Methicillin Resistance; Middle Aged; Oxazolidinones; Spain; Staphylococcus epidermidis; Staphylococcus haemolyticus | 2013 |
Potential serious adverse interactions between linezolid and atomoxetine.
Topics: Acetamides; Anti-Bacterial Agents; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Bacterial Infections; Child; Cystic Fibrosis; Drug Interactions; Female; Humans; Linezolid; Monoamine Oxidase Inhibitors; Oxazolidinones; Propylamines; Sputum | 2012 |
Vancomycin versus linezolid in the treatment of methicillin-resistant Staphylococcus aureus meningitis in an experimental rabbit model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Disease Models, Animal; Linezolid; Meningitis, Bacterial; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Rabbits; Staphylococcal Infections; Vancomycin | 2012 |
[Vancomycin-resistant enterococci (VRE). Recent results and trends in development of antibiotic resistance].
Topics: Acetamides; Bacterial Proteins; Carbon-Oxygen Ligases; Cross Infection; Cross-Sectional Studies; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Population Surveillance; Serotyping; Teicoplanin; Vancomycin Resistance | 2012 |
Periprosthetic atypical mycobacterial infection in breast implants: a new kid on the block!
Topics: Acetamides; Adult; Amikacin; Anti-Bacterial Agents; Antitubercular Agents; Breast Implants; Clarithromycin; Female; Fluoroquinolones; Gatifloxacin; Humans; Linezolid; Mammaplasty; Mycobacterium chelonae; Mycobacterium fortuitum; Mycobacterium Infections, Nontuberculous; Oxazolidinones; Reoperation | 2013 |
Challenging trials.
Topics: Acetamides; Antitubercular Agents; Female; Humans; Linezolid; Male; Oxazolidinones; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2012 |
Empiric therapy directed against MRSA in patients admitted to the intensive care unit does not improve outcomes in community-acquired pneumonia.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Community-Acquired Infections; Comorbidity; Empirical Research; Female; Hospital Mortality; Humans; Intensive Care Units; Length of Stay; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Pneumonia, Bacterial; Prevalence; Proportional Hazards Models; Retrospective Studies; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2013 |
Topical linezolid for refractory bilateral Mycobacterium chelonae post-laser-assisted in situ keratomileusis keratitis.
Topics: Acetamides; Adult; Anti-Infective Agents; Cornea; Drug Resistance, Bacterial; Eye Infections, Bacterial; Follow-Up Studies; Humans; Keratitis; Keratomileusis, Laser In Situ; Linezolid; Male; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Myopia; Oxazolidinones; RNA, Ribosomal, 23S; Surgical Wound Infection | 2012 |
Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja.
Topics: 4-Butyrolactone; Acetamides; Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Positive Bacteria; Linezolid; Marine Biology; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxazolidinones; Republic of Korea; Urochordata; Vancomycin | 2012 |
[Antibiotics].
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; beta-Lactams; Chloramphenicol; Fosfomycin; Glycopeptides; Humans; Ketolides; Linezolid; Macrolides; Oxazolidinones; Peptides; Streptogramins; Tetracyclines; Trimethoprim, Sulfamethoxazole Drug Combination | 2012 |
Oral bioavailability of linezolid before and after Roux-en-Y gastric bypass surgery: is dose modification necessary in obese subjects?
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Biological Availability; Chromatography, High Pressure Liquid; Female; Gastric Bypass; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Serum; Spectrophotometry, Ultraviolet | 2013 |
Inhibition of biofilm maturation by linezolid in meticillin-resistant Staphylococcus epidermidis clinical isolates: comparison with other drugs.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Bacterial Proteins; Bacteriological Techniques; Biofilms; Dose-Response Relationship, Drug; Gene Expression Regulation, Bacterial; Linezolid; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus epidermidis | 2013 |
Vancomycin-resistant enterococcal meningitis in an autologous stem cell transplant recipient cured with linezolid.
Topics: Acetamides; Anti-Infective Agents; Enterococcus; Female; Gram-Positive Bacterial Infections; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Linezolid; Meningitis, Bacterial; Middle Aged; Oxazolidinones; Transplantation, Autologous; Treatment Outcome; Vancomycin Resistance | 2013 |
ZAAPS Program results for 2010: an activity and spectrum analysis of linezolid using clinical isolates from 75 medical centres in 24 countries.
Topics: Acetamides; Anti-Bacterial Agents; Asia; Australia; Canada; Drug Resistance, Bacterial; Enterococcus; Europe; Humans; Latin America; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Public Health Surveillance; Staphylococcal Infections; Staphylococcus | 2012 |
[Evaluation of vancomycin-resistant Enterococcus cases at a tertiary level hospital in Izmir, Turkey].
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cross Infection; Culture Media; Daptomycin; Enterococcus; Environmental Microbiology; Female; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Turkey; Vancomycin Resistance; Young Adult | 2012 |
Activity of ceftaroline against extracellular (broth) and intracellular (THP-1 monocytes) forms of methicillin-resistant Staphylococcus aureus: comparison with vancomycin, linezolid and daptomycin.
Topics: Acetamides; Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Monocytes; Oxazolidinones; Vancomycin | 2013 |
[Emergence of linezolid-resistant Enterococcus faecalis strains from two inpatients in a pediatric ward].
Topics: Acetamides; Anti-Infective Agents; Child; Child, Preschool; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecalis; Female; Humans; Linezolid; Male; Oxazolidinones; Polymerase Chain Reaction | 2012 |
Predictors and outcomes of linezolid-resistant vancomycin-resistant Enterococcus: a case-case-control study.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Case-Control Studies; Drug Resistance, Bacterial; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Risk Factors; Treatment Outcome; Vancomycin | 2012 |
Disseminated Nocardiosis caused by Nocardia concava with acute respiratory failure and central nervous system involvement treated with linezolid.
Topics: Acetamides; Acute Disease; Aged; Anti-Bacterial Agents; Central Nervous System Diseases; Humans; Immunocompromised Host; Linezolid; Male; Microbial Sensitivity Tests; Minocycline; Nocardia; Nocardia Infections; Oxazolidinones; Respiratory Insufficiency; Trimethoprim, Sulfamethoxazole Drug Combination | 2012 |
In vivo bioluminescence imaging to evaluate systemic and topical antibiotics against community-acquired methicillin-resistant Staphylococcus aureus-infected skin wounds in mice.
Topics: Acetamides; Administration, Oral; Administration, Topical; Animals; Anti-Bacterial Agents; Bacterial Load; Bridged Bicyclo Compounds, Heterocyclic; Clindamycin; Community-Acquired Infections; Daptomycin; Diabetes Mellitus, Type 2; Disease Models, Animal; Diterpenes; Doxycycline; Linezolid; Luminescent Measurements; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred C57BL; Mupirocin; Oxazolidinones; Skin; Soft Tissue Infections; Staphylococcal Infections; Staphylococcal Skin Infections; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin; Wound Healing | 2013 |
Treatment of methicillin-resistant Staphylococcus aureus infections with a minimal inhibitory concentration of 2 μg/mL to vancomycin: old (trimethoprim/sulfamethoxazole) versus new (daptomycin or linezolid) agents.
Topics: Acetamides; Adult; Age Factors; Aged; Anti-Bacterial Agents; Cohort Studies; Cost Savings; Daptomycin; Drug Costs; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Multivariate Analysis; Oxazolidinones; Retrospective Studies; Severity of Illness Index; Staphylococcal Infections; Time Factors; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin | 2012 |
Screening, isolation, taxonomy and fermentation of an antibiotic producer Streptomyces xinghaiensis from soil capable of acting against linezolid resistant strains.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Artemia; Chromatography, High Pressure Liquid; Drug Resistance, Bacterial; Fermentation; Humans; Larva; Linezolid; Magnetic Resonance Spectroscopy; Molecular Structure; Mycobacterium tuberculosis; Neoplasms; Oxazolidinones; Phylogeny; Protein Synthesis Inhibitors; Soil; Soil Microbiology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Streptomyces; Toxicity Tests; Tuberculosis; Tumor Cells, Cultured | 2012 |
Intraventricular daptomycin and intravenous linezolid for the treatment of external ventricular-drain-associated ventriculitis due to vancomycin-resistant Enterococcus faecium.
Topics: Acetamides; Administration, Intravenous; Anti-Bacterial Agents; Cerebral Ventriculitis; Daptomycin; Dose-Response Relationship, Drug; Drainage; Drug Therapy, Combination; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Injections, Intraventricular; Linezolid; Male; Middle Aged; Oxazolidinones; Treatment Outcome; Vancomycin Resistance | 2012 |
Drosophila melanogaster as a model to explore the effects of methicillin-resistant Staphylococcus aureus strain type on virulence and response to linezolid treatment.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drosophila melanogaster; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Virulence | 2013 |
Pharmacokinetics of intravenous linezolid in moderately to morbidly obese adults.
Topics: Acetamides; Adult; Area Under Curve; Body Mass Index; Body Weight; Drug Dosage Calculations; Female; Humans; Injections, Intravenous; Linezolid; Male; Middle Aged; Obesity, Morbid; Oxazolidinones; Prospective Studies; Protein Synthesis Inhibitors; Severity of Illness Index | 2013 |
Linezolid surveillance results for the United States: LEADER surveillance program 2011.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Gram-Positive Bacteria; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Product Surveillance, Postmarketing; Staphylococcus aureus; Streptococcus pneumoniae; United States; Young Adult | 2013 |
The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L.
Topics: Acetamides; Aged; Alleles; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Female; Gene Expression Regulation, Bacterial; Humans; Linezolid; Methyltransferases; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Plasmids; Promoter Regions, Genetic; Ribosomal Proteins; RNA, Messenger; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus epidermidis; Transcription, Genetic | 2013 |
Linezolid dependence in Staphylococcus epidermidis bloodstream isolates.
Topics: Acetamides; Adult; Aged; Amino Acid Substitution; Anti-Bacterial Agents; DNA, Bacterial; Drug Resistance, Bacterial; Female; Greece; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Point Mutation; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Serotyping; Staphylococcal Infections; Staphylococcus epidermidis | 2013 |
A new approach for antibiotic drugs determination in human plasma by liquid chromatography-mass spectrometry.
Topics: Acetamides; Aged; Amoxicillin; Anti-Bacterial Agents; Chromatography, Liquid; Fluoroquinolones; Gemifloxacin; Humans; Linezolid; Mass Spectrometry; Middle Aged; Naphthyridines; Oxazolidinones; Reproducibility of Results; Solid Phase Microextraction | 2013 |
Fosfomycin synergy in vitro with amoxicillin, daptomycin, and linezolid against vancomycin-resistant Enterococcus faecium from renal transplant patients with infected urinary stents.
Topics: Acetamides; Amoxicillin; Anti-Bacterial Agents; Daptomycin; Drug Synergism; Enterococcus faecium; Fosfomycin; Gram-Positive Bacterial Infections; Humans; Kidney Transplantation; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Stents; Urinary Tract; Urinary Tract Infections; Vancomycin; Vancomycin Resistance | 2013 |
A facile synthesis, antibacterial activity of pulvinone and its derivatives.
Topics: 4-Butyrolactone; Acetamides; Anti-Bacterial Agents; Benzylidene Compounds; Gram-Negative Bacteria; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Structure-Activity Relationship | 2013 |
[A case of refractory deep incisional surgical site infection due to methicillin-resistant Staphylococcus aureus (MRSA) and successfully treated with oral linezolid].
Topics: Acetamides; Administration, Oral; Aged; Anti-Infective Agents; Gastrectomy; Humans; Linezolid; Male; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections; Stomach Neoplasms; Surgical Wound Infection | 2012 |
Mechanisms of linezolid resistance among Staphylococci in a tertiary hospital.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Bacterial; Humans; Intensive Care Units; Linezolid; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus haemolyticus; Tertiary Care Centers | 2013 |
Improving linezolid use decreases the incidence of resistance among Gram-positive microorganisms.
Topics: Acetamides; Anti-Bacterial Agents; Drug Prescriptions; Drug Resistance, Bacterial; Drug Utilization; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Guideline Adherence; Humans; Incidence; Linezolid; Organizational Policy; Oxazolidinones; Prospective Studies; Tertiary Care Centers | 2013 |
Inoculum effects of ceftobiprole, daptomycin, linezolid, and vancomycin with Staphylococcus aureus and Streptococcus pneumoniae at inocula of 10(5) and 10(7) CFU injected into opposite thighs of neutropenic mice.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Cephalosporins; Colony Count, Microbial; Daptomycin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Injections, Subcutaneous; Linezolid; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Neutropenia; Oxazolidinones; Pneumococcal Infections; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Thigh; Vancomycin | 2013 |
Reduced drug uptake in phenotypically resistant nutrient-starved nonreplicating Mycobacterium tuberculosis.
Topics: Acetamides; Antitubercular Agents; Fluoroquinolones; Gene Expression Regulation, Bacterial; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Rifamycins | 2013 |
Worrisome trend of new multiple mechanisms of linezolid resistance in staphylococcal clones diffused in Italy.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Genes, Bacterial; Humans; Italy; Linezolid; Mutation; Oxazolidinones; Prevalence; Prospective Studies; Staphylococcal Infections; Staphylococcus | 2013 |
Methicillin-resistant Staphylococcus aureus-induced thrombo-inflammatory response is reduced with timely antibiotic administration.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Blood Coagulation; Cell-Derived Microparticles; Cytokines; Drug Administration Schedule; Humans; Inflammation; Inflammation Mediators; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred C57BL; Monocytes; Oxazolidinones; Sepsis; Staphylococcal Infections; Thrombin; Thrombosis; Time Factors; Vancomycin | 2013 |
Pharmacokinetics and elimination efficiency of linezolid during dialysis.
Topics: Acetamides; Aged; Amputation, Surgical; Anti-Infective Agents; Bacteremia; Female; Humans; Kidney Failure, Chronic; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Renal Dialysis; Staphylococcal Infections; Surgical Wound Infection | 2013 |
[A case of pacemaker-lead infection by linezolid-resistant methicillin-resistant Staphylococcus aureus in a hemodialysis patient].
Topics: Acetamides; Aged; Anti-Infective Agents; Female; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pacemaker, Artificial; Prosthesis-Related Infections; Renal Dialysis; Sepsis; Staphylococcal Infections | 2012 |
Recurrent infection in a late presentation of catecholaminergic polymorphic VT.
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Recurrence; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Tachycardia, Ventricular; Time Factors; Treatment Outcome | 2013 |
Improved outcome of ventilator-associated pneumonia caused by methicillin-resistant Staphylococcus aureus in a trauma population.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Bronchoalveolar Lavage; Female; Humans; Intensive Care Units; Length of Stay; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Pneumonia, Staphylococcal; Pneumonia, Ventilator-Associated; Retrospective Studies; Treatment Outcome; Vancomycin; Wounds, Nonpenetrating | 2013 |
Risk factors for a low linezolid trough plasma concentration in acute infections.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Risk Factors; Staphylococcal Infections; Staphylococcus aureus | 2013 |
Anti-inflammatory, anti-coagulant, anti-biotic?
Topics: Acetamides; Animals; Anti-Bacterial Agents; Humans; Inflammation; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Sepsis; Staphylococcal Infections; Thrombosis; Vancomycin | 2013 |
Severe sepsis caused by a linezolid-resistant Enterococcus faecium in a 10-year-old girl after multiple trauma.
Topics: Acetamides; Anti-Bacterial Agents; Child; Drug Resistance, Bacterial; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Multiple Trauma; Oxazolidinones; Sepsis | 2013 |
[Resistance to linezolid: a laboratory curiosity or an important clinical problem?].
Topics: Acetamides; Anti-Infective Agents; Female; Humans; Linezolid; Male; Methicillin Resistance; Oxazolidinones; Staphylococcus epidermidis; Staphylococcus haemolyticus | 2013 |
Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacteriophages; Diabetes Mellitus, Experimental; Diabetic Foot; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Oxazolidinones; Staphylococcal Skin Infections; Treatment Outcome | 2013 |
Otogenic cerebellar abscess by Enterococcus avium, a very rare infectious agent.
Topics: Acetamides; Anti-Bacterial Agents; Brain Abscess; Cerebellar Diseases; Ciprofloxacin; Enterococcus; Female; Gram-Negative Bacterial Infections; Humans; Injections, Intravenous; Linezolid; Magnetic Resonance Imaging; Metronidazole; Middle Aged; Nervous System Diseases; Oxazolidinones; Tomography, X-Ray Computed | 2013 |
Pharmacokinetics, pharmacodynamics and efficacy of novel FabI inhibitor AFN-1252 against MSSA and MRSA in the murine thigh infection model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Benzofurans; Community-Acquired Infections; Female; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxazolidinones; Pyrones; Staphylococcal Infections; Staphylococcus aureus; Thigh | 2013 |
Cfr-mediated linezolid-resistance among methicillin-resistant coagulase-negative staphylococci from infections of humans.
Topics: Acetamides; Bacterial Proteins; Coagulase; Drug Resistance, Multiple, Bacterial; Gene Order; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Typing; Mutation; Oxazolidinones; Plasmids; Ribosomal Protein L3; Staphylococcal Infections; Staphylococcus; Staphylococcus haemolyticus | 2013 |
Treatment with linezolid in a neonate with meningitis caused by methicillin-resistant Staphylococcus epidermidis.
Topics: Acetamides; Anti-Infective Agents; Female; Humans; Infant, Newborn; Linezolid; Meningitis, Bacterial; Methicillin Resistance; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Treatment Outcome | 2013 |
Emergence of cfr-harbouring coagulase-negative staphylococci among patients receiving linezolid therapy in two hospitals in China.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Proteins; China; Coagulase; Cross Infection; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Sequence Data; Oxazolidinones; Plasmids; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus; Staphylococcus epidermidis; Staphylococcus hominis | 2013 |
Daptomycin plus trimethoprim/sulfamethoxazole combination therapy in post-neurosurgical meningitis caused by linezolid-resistant Staphylococcus epidermidis.
Topics: Acetamides; Anti-Bacterial Agents; Blood-Brain Barrier; Daptomycin; Female; Glycopeptides; Humans; Linezolid; Meningitis; Methicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Staphylococcus epidermidis; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination | 2013 |
Topical linezolid 0.2% for the treatment of vancomycin-resistant or vancomycin-intolerant gram-positive bacterial keratitis.
Topics: Acetamides; Administration, Topical; Anti-Infective Agents; Corneal Ulcer; Enterococcus faecalis; Eye Infections, Bacterial; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Ophthalmic Solutions; Oxazolidinones; Retrospective Studies; Staphylococcus; Streptococcus mitis; Vancomycin Resistance | 2013 |
Pharmacokinetics of linezolid during extracorporeal membrane oxygenation.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Area Under Curve; Extracorporeal Membrane Oxygenation; Female; Half-Life; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Plasma | 2013 |
Detection of linezolid-resistant Staphylococcus aureus with 23S rRNA and novel L4 riboprotein mutations in a cystic fibrosis patient in Spain.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Cystic Fibrosis; Drug Resistance, Bacterial; Female; Humans; Linezolid; Mutation; Oxazolidinones; Ribosomal Proteins; RNA, Ribosomal, 23S; Spain; Staphylococcal Infections; Staphylococcus aureus | 2013 |
Linezolid-induced lactic acidosis followed by severe hypophosphatemia after discontinuation of linezolid.
Topics: Acetamides; Acidosis, Lactic; Aged; Anti-Infective Agents; Humans; Hypophosphatemia; Linezolid; Male; Oxazolidinones; Phosphates; Potassium Compounds; Sepsis; Substance Withdrawal Syndrome | 2013 |
[Nocardia pseudobrasiliensis pneumonia in a heart transplant recipient].
Topics: Acetamides; Adult; Ciprofloxacin; Drug Resistance, Multiple, Bacterial; Heart Transplantation; Humans; Imipenem; Immunocompromised Host; Linezolid; Male; Nocardia; Nocardia Infections; Oxazolidinones; Pneumonia, Bacterial; Postoperative Complications; Tomography, X-Ray Computed; Trimethoprim, Sulfamethoxazole Drug Combination | 2013 |
An international activity and spectrum analysis of linezolid: ZAAPS Program results for 2011.
Topics: Acetamides; Anti-Bacterial Agents; Brazil; Child; Child, Preschool; Drug Resistance, Multiple, Bacterial; Enterococcus; Female; France; Germany; Greece; Hong Kong; Humans; Infant; Ireland; Italy; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Reproducibility of Results; RNA, Bacterial; Spain; Spectrum Analysis; Staphylococcus; Staphylococcus aureus; Streptococcus; Treatment Outcome; Viridans Streptococci | 2013 |
Effect of linezolid on clinical severity and pulmonary cytokines in a murine model of influenza A and Staphylococcus aureus coinfection.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Load; Coinfection; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Immunologic Factors; Influenza A virus; Influenza, Human; Interleukins; Linezolid; Lung; Mice; Mice, Inbred C57BL; Oxazolidinones; Severity of Illness Index; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Viral Load; Weight Loss | 2013 |
Quantifying subpopulation synergy for antibiotic combinations via mechanism-based modeling and a sequential dosing design.
Topics: Acetamides; Amikacin; Colony Count, Microbial; Drug Dosage Calculations; Drug Synergism; Drug Therapy, Combination; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Models, Statistical; Nisin; Oxazolidinones | 2013 |
In vitro activity of daptomycin & linezolid against methicillin resistant Staphylococcus aureus & vancomycin resistant enterococci isolated from hospitalized cases in Central India.
Topics: Acetamides; Daptomycin; Enterococcus; Humans; In Vitro Techniques; India; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Teicoplanin; Vancomycin Resistance | 2013 |
Spectrum of gram-positive bacteraemia and in vitro activities of daptomycin, linezolid and vancomycin against organisms isolated from cancer patients.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Child; Child, Preschool; Daptomycin; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Neoplasms; Oxazolidinones; Prevalence; Vancomycin; Young Adult | 2013 |
Antidepressant activity of linezolid.
Topics: Acetamides; Aged, 80 and over; Antidepressive Agents; Depression; Female; Humans; Hypertension; Linezolid; Lung Diseases, Obstructive; Osteoporosis; Oxazolidinones | 2013 |
Susceptibility testing of extensively drug-resistant and pre-extensively drug-resistant Mycobacterium tuberculosis against levofloxacin, linezolid, and amoxicillin-clavulanate.
Topics: Acetamides; Amoxicillin-Potassium Clavulanate Combination; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Humans; Levofloxacin; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Ofloxacin; Oxazolidinones; Pakistan; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2013 |
Linezolid-induced serotonin syndrome.
Topics: Acetamides; Adult; Anti-Infective Agents; Humans; Linezolid; Male; Oxazolidinones; Serotonin Syndrome | 2013 |
Sccmec type II gene is common among clinical isolates of methicillin-resistant Staphylococcus aureus in Jakarta, Indonesia.
Topics: Acetamides; Amikacin; Clindamycin; Community-Acquired Infections; Cross Infection; DNA Primers; Drug Resistance, Multiple, Bacterial; Genes, Bacterial; Humans; Indonesia; Linezolid; Methicillin-Resistant Staphylococcus aureus; Minocycline; Oxazolidinones; Plasmids; Polymerase Chain Reaction; Species Specificity; Teicoplanin; Tigecycline; Time Factors; Vancomycin | 2013 |
Effects of linezolid on suppressing in vivo production of staphylococcal toxins and improving survival outcomes in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumonia.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Load; Bacterial Toxins; Chemokine CCL2; Disease Models, Animal; Exotoxins; Hemolysin Proteins; Interleukin-8; Leukocidins; Linezolid; Lung; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Rabbits; Vancomycin | 2013 |
Dissecting the mechanisms of linezolid resistance in a Drosophila melanogaster infection model of Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Resistance, Bacterial; Female; Linezolid; Mice; Mice, Inbred ICR; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2013 |
Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Hospitals; Humans; Linezolid; Male; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Spain; Staphylococcal Infections | 2013 |
[Bacteriophage therapy and diabetic foot ulcer].
Topics: Acetamides; Animals; Anti-Infective Agents; Bacteriophages; Combined Modality Therapy; Diabetes Mellitus, Experimental; Diabetic Foot; Humans; Linezolid; Mice; Mice, Inbred BALB C; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Superinfection | 2013 |
Linezolid plasma concentrations and occurrence of drug-related haematological toxicity in patients with gram-positive infections.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Blood Cells; Drug Monitoring; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Plasma; Prospective Studies; Risk Assessment | 2013 |
Host gene expression profiling and in vivo cytokine studies to characterize the role of linezolid and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA) murine sepsis model.
Topics: Acetamides; Animals; Gene Expression Profiling; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Oxazolidinones; Sepsis; Vancomycin | 2013 |
[Actinomycetoma of the knee due to Nocardia otitidiscaviarum described in the Comoro Islands].
Topics: Accidents, Traffic; Acetamides; Adult; Anti-Infective Agents; Comoros; Humans; Knee; Knee Injuries; Linezolid; Male; Mycetoma; Nocardia; Oxazolidinones; Skin; Trimethoprim, Sulfamethoxazole Drug Combination; Tropical Climate | 2013 |
Dissemination of a pSCFS3-like cfr-carrying plasmid in Staphylococcus aureus and Staphylococcus epidermidis clinical isolates recovered from hospitals in Ohio.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Cattle; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Sequence Data; Multilocus Sequence Typing; Ohio; Oxazolidinones; Plasmids; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis | 2013 |
Efficacy of tigecycline alone and in combination with gentamicin in the treatment of experimental endocarditis due to linezolid-resistant Enterococcus faecium.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Endocarditis, Bacterial; Enterococcus faecium; Gentamicins; Gram-Positive Bacterial Infections; Linezolid; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Rabbits; Tigecycline | 2013 |
Investigation of in vitro antileishmanial activity of moxifloxacin, linezolid and caspofungin on Leishmania tropica promastigotes.
Topics: Acetamides; Aza Compounds; Caspofungin; Echinocandins; Fluoroquinolones; Leishmania tropica; Linezolid; Lipopeptides; Moxifloxacin; Oxazolidinones; Quinolines; Trypanocidal Agents | 2013 |
Antimicrobial/anti-biofilm activity of expired blood platelets and their released products.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; beta-Thromboglobulin; Biofilms; Blood Platelets; Endocarditis, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxacillin; Oxazolidinones; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Vancomycin | 2013 |
High plasma linezolid concentration and impaired renal function affect development of linezolid-induced thrombocytopenia.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Female; Humans; Kidney Diseases; Kidney Function Tests; Linezolid; Male; Middle Aged; Oxazolidinones; Plasma; Prospective Studies; Thrombocytopenia | 2013 |
Antimicrobial activity of ceftaroline tested against staphylococci with reduced susceptibility to linezolid, daptomycin, or vancomycin from U.S. hospitals, 2008 to 2011.
Topics: Acetamides; Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Daptomycin; Hospitals; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2013 |
First report of Nocardia asiatica olecranon bursitis in an immunocompetent traveler returning to Austria.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Austria; Bursitis; DNA, Bacterial; Humans; Linezolid; Male; Molecular Sequence Data; Nocardia; Nocardia Infections; Olecranon Process; Oxazolidinones; Sequence Analysis, DNA; Thailand; Travel; Treatment Outcome | 2013 |
Combined effect of linezolid and N-acetylcysteine against Staphylococcus epidermidis biofilms.
Topics: Acetamides; Acetylcysteine; Anti-Infective Agents; Biofilms; Drug Therapy, Combination; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus epidermidis | 2013 |
Can intermittent dosing optimize prolonged linezolid treatment of difficult multidrug-resistant tuberculosis?
Topics: Acetamides; Adult; Antitubercular Agents; Drug Administration Schedule; Female; Humans; Linezolid; Male; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Sputum; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Young Adult | 2013 |
Emergence of mutation-based linezolid-resistant invasive Enterococcus faecalis in a haemodialysis patient in Norway.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Genes, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Mutation; Norway; Oxazolidinones; Renal Dialysis | 2014 |
Disseminated staphylococcal disease in healthy children-experience from two tertiary care hospitals of West Bengal.
Topics: Acetamides; Adolescent; Anti-Infective Agents; Arthritis, Infectious; Child; Child, Preschool; Female; Humans; Immunocompetence; Linezolid; Magnetic Resonance Imaging; Male; Oxazolidinones; Risk Factors; Staphylococcal Skin Infections; Tomography, X-Ray Computed | 2014 |
Unwanted baggage.
Topics: Acetamides; Aged, 80 and over; Anti-Bacterial Agents; Corynebacterium; Corynebacterium Infections; Female; Humans; Leg Injuries; Leg Ulcer; Linezolid; Oxazolidinones; Skin; Systemic Inflammatory Response Syndrome | 2013 |
Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus keratitis in rabbits.
Topics: Acetamides; Administration, Topical; Animals; Anti-Bacterial Agents; Bacterial Load; Colony Count, Microbial; Colony-Forming Units Assay; Corneal Ulcer; Disease Models, Animal; Eye Infections, Bacterial; Linezolid; Methicillin-Resistant Staphylococcus aureus; Ophthalmic Solutions; Oxazolidinones; Rabbits; Staphylococcal Infections; Vancomycin | 2013 |
Vancomycin versus linezolid in the treatment of methicillin-resistant Staphylococcus aureus meningitis.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Cohort Studies; Female; Humans; Linezolid; Male; Meningitis, Bacterial; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Retrospective Studies; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2013 |
Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution.
Topics: Acetamides; Bacterial Outer Membrane Proteins; Bacterial Proteins; Cell Membrane; Crystallography, X-Ray; Drug Resistance, Multiple, Bacterial; Escherichia coli Proteins; Linezolid; Models, Molecular; Oxazolidinones; Periplasm | 2013 |
Influence of the MBC/MIC ratio on the antibacterial activity of vancomycin versus linezolid against methicillin-resistant Staphylococcus aureus isolates in a pharmacodynamic model simulating serum and soft tissue interstitial fluid concentrations reported
Topics: Acetamides; Anti-Bacterial Agents; Diabetes Mellitus; Extracellular Fluid; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microbial Viability; Models, Theoretical; Oxazolidinones; Serum; Vancomycin | 2013 |
In vitro activities of PNU-100480 and linezolid against drug-susceptible and drug-resistant Mycobacterium tuberculosis isolates.
Topics: Acetamides; Antitubercular Agents; Hong Kong; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis | 2013 |
Pharmacokinetics of linezolid in the mediastinum and pleural space.
Topics: Acetamides; Anti-Infective Agents; Extracellular Fluid; Humans; Linezolid; Male; Mediastinitis; Mediastinum; Oxazolidinones; Permeability; Pleural Cavity; Pleural Effusion | 2013 |
Linezolid resistance in Brazilian Staphylococcus hominis strains is associated with L3 and 23S rRNA ribosomal mutations.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Brazil; Drug Resistance, Multiple, Bacterial; Genes, Bacterial; Humans; Intensive Care Units; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Ribosomal Proteins; Ribosomes; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus hominis; Tertiary Care Centers | 2013 |
Streptococcus sanguinis isolate displaying a phenotype with cross-resistance to several rRNA-targeting agents.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Coinfection; Drug Resistance, Bacterial; Endocarditis, Bacterial; Humans; Linezolid; Male; Mutation, Missense; Oxazolidinones; Phenotype; Point Mutation; Ribosomal Proteins; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus epidermidis; Streptococcal Infections; Streptococcus | 2013 |
Evaluating the impact of a pharmacist's absence from an antimicrobial stewardship team.
Topics: Acetamides; Anti-Infective Agents; Antifungal Agents; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Resistance, Microbial; Echinocandins; Guideline Adherence; Humans; Imipenem; Length of Stay; Linezolid; Lipopeptides; Medication Errors; Medication Therapy Management; Micafungin; Ohio; Oxazolidinones; Patient Care Team; Pharmacy Service, Hospital; Retrospective Studies; Workforce | 2013 |
Spectrofluorimetric determination of terbinafine hydrochloride and linezolid in their dosage forms and human plasma.
Topics: Acetamides; Humans; Linezolid; Molecular Structure; Naphthalenes; Oxazolidinones; Spectrometry, Fluorescence; Terbinafine | 2013 |
Characterization and monitoring of linezolid-resistant clinical isolates of Staphylococcus epidermidis in an intensive care unit 4 years after an outbreak of infection by cfr-mediated linezolid-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Cross Infection; Disease Outbreaks; DNA Mutational Analysis; Drug Resistance, Bacterial; Humans; Intensive Care Units; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Point Mutation; Ribosomal Protein L3; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis | 2013 |
Virulence of vancomycin-resistant Enterococcus faecium according to linezolid resistance and clinical outbreak status.
Topics: Acetamides; Animals; Chicago; Disease Models, Animal; Disease Outbreaks; Disk Diffusion Antimicrobial Tests; Enterococcus faecium; Gram-Positive Bacterial Infections; Hospital Bed Capacity, 500 and over; Humans; Kaplan-Meier Estimate; Linezolid; Moths; Oxazolidinones; Time Factors; Vancomycin; Vancomycin Resistance | 2013 |
Analysis of the small RNA transcriptional response in multidrug-resistant Staphylococcus aureus after antimicrobial exposure.
Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Protein Biosynthesis; RNA, Bacterial; RNA, Messenger; RNA, Small Untranslated; Sequence Analysis, RNA; Tigecycline; Transcription, Genetic; Vancomycin | 2013 |
Antimicrobial susceptibility and molecular typing of MRSA in cystic fibrosis.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Bronchoscopy; Child; Child, Preschool; Cohort Studies; Cystic Fibrosis; DNA, Bacterial; Exotoxins; Female; Fosfomycin; Fusidic Acid; Humans; Leukocidins; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Molecular Typing; Mupirocin; Oxazolidinones; Penicillin-Binding Proteins; Pharynx; Pneumonia, Staphylococcal; Sequence Analysis, DNA; Sputum; Staphylococcal Infections; Staphylococcal Protein A; Tetracycline; Tigecycline; Trimethoprim, Sulfamethoxazole Drug Combination; United States | 2014 |
Successful port-a-cath salvage using linezolid in children with acute leukemia.
Topics: Acetamides; Anti-Infective Agents; Central Venous Catheters; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Myeloid, Acute; Linezolid; Male; Oxazolidinones; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Salvage Therapy; Staphylococcal Infections; Staphylococcus | 2013 |
New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens.
Topics: Acetamides; Anti-Bacterial Agents; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Hep G2 Cells; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Oxadiazoles; Oxazolidinones; Software; Structure-Activity Relationship | 2013 |
Antibiotic prescription for respiratory tract infections in ventilated patients: where are we heading?
Topics: Acetamides; Anti-Infective Agents; Antibiotic Prophylaxis; Female; Humans; Linezolid; Male; Meropenem; Oxazolidinones; Pneumonia, Ventilator-Associated; Thienamycins | 2013 |
Validation of a new HPLC-UV method for determination of the antibiotic linezolid in human plasma and in bronchoalveolar lavage.
Topics: Acetamides; Anti-Infective Agents; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Limit of Detection; Linezolid; Oxazolidinones; Solid Phase Extraction; Spectrophotometry, Ultraviolet; Time Factors | 2013 |
Tigecycline induction of phenol-soluble modulins by invasive methicillin-resistant Staphylococcus aureus strains.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Toxins; Clindamycin; Culture Media; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Protein Isoforms; Staphylococcal Infections; Tigecycline | 2013 |
Filgrastim therapy in a child with neutropenia induced by linezolid.
Topics: Acetamides; Antitubercular Agents; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Infant; Leukocyte Count; Linezolid; Male; Neutropenia; Off-Label Use; Oxazolidinones; Recombinant Proteins; Severity of Illness Index; Time Factors; Tuberculosis, Multidrug-Resistant | 2013 |
Linezolid decreases susceptibility to secondary bacterial pneumonia postinfluenza infection in mice through its effects on IFN-γ.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Load; Bronchoalveolar Lavage Fluid; CD4 Lymphocyte Count; Coinfection; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Influenza A virus; Interferon-gamma; Linezolid; Lung; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Oxazolidinones; Pneumonia, Pneumococcal; Recombinant Proteins; Tumor Necrosis Factor-alpha; Viral Load; Virus Replication | 2013 |
Efficacy of topical and systemic antibiotic treatment of meticillin-resistant Staphylococcus aureus in a murine superficial skin wound infection model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacterial Load; Bridged Bicyclo Compounds, Heterocyclic; Diterpenes; Female; Fusidic Acid; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mupirocin; Oxazolidinones; Staphylococcal Skin Infections; Vancomycin; Wound Infection | 2013 |
Further isolation of Mycobacterium abscessus subsp. abscessus and subsp. bolletii in different regions of Japan and susceptibility of these isolates to antimicrobial agents.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Chaperonin 60; Clarithromycin; DNA-Directed RNA Polymerases; DNA, Intergenic; Drug Resistance, Bacterial; Female; Genotype; Humans; Japan; Linezolid; Male; Methyltransferases; Microbial Sensitivity Tests; Middle Aged; Mycobacterium; Mycobacterium Infections; Oxazolidinones; RNA, Ribosomal, 23S; Sequence Analysis, DNA | 2013 |
Tissue penetration and antimicrobial activity of standard- and high-dose trimethoprim/sulfamethoxazole and linezolid in patients with diabetic foot infection.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Chromatography, Liquid; Diabetic Foot; Female; Humans; Linezolid; Male; Middle Aged; Outpatients; Oxazolidinones; Serum; Skin; Staphylococcus aureus; Streptococcus; Tandem Mass Spectrometry; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination | 2013 |
Antimicrobial activity of linezolid combined with minocycline against vancomycin-resistant Enterococci.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Therapy, Combination; Enterococcus; Linezolid; Microbial Sensitivity Tests; Minocycline; Mutation; Oxazolidinones; Vancomycin Resistance | 2013 |
Effect of pulmonary surfactant on antimicrobial activity in vitro.
Topics: Acetamides; Animals; Anti-Infective Agents; Aza Compounds; Carbapenems; Colistin; Daptomycin; Doripenem; Fluoroquinolones; Linezolid; Microbial Sensitivity Tests; Minocycline; Moxifloxacin; Oxazolidinones; Pulmonary Surfactants; Quinolines; Staphylococcus aureus; Swine; Tigecycline | 2013 |
Linezolid-resistant clinical isolates of enterococci and Staphylococcus cohnii from a multicentre study in China: molecular epidemiology and resistance mechanisms.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Child, Preschool; China; Cluster Analysis; DNA, Bacterial; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Hospitals; Humans; Infant; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Epidemiology; Molecular Sequence Data; Multilocus Sequence Typing; Oxazolidinones; Plasmids; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Staphylococcus; Young Adult | 2013 |
[Management of late-onset sepsis due to coagulase-negative staphylococci in neonatal intensive care units].
Topics: Acetamides; Anti-Infective Agents; Daptomycin; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Linezolid; Oxazolidinones; Sepsis; Staphylococcal Infections; Vancomycin Resistance | 2013 |
Rapid emergence of resistance to linezolid and mutator phenotypes in Staphylococcus aureus isolates from an adult cystic fibrosis patient.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Cystic Fibrosis; Humans; Linezolid; Oxazolidinones; RNA, Ribosomal, 23S; Staphylococcus aureus | 2013 |
Population pharmacokinetic analysis of linezolid in low body weight patients with renal dysfunction.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Anti-Bacterial Agents; Body Weight; Creatinine; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Models, Biological; Oxazolidinones; Renal Insufficiency; Staphylococcal Infections | 2013 |
[The incidence and risk factors for heterogeneous vancomycin intermediate Staphylococcus aureus].
Topics: Acetamides; Aged; Anti-Bacterial Agents; Area Under Curve; Case-Control Studies; Humans; Incidence; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Prevalence; Pulmonary Disease, Chronic Obstructive; Retrospective Studies; Risk Factors; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Treatment Outcome; Vancomycin; Vancomycin Resistance | 2013 |
Clinical experience of using clofazimine to treat multidrug-resistant tuberculosis [Correspondence].
Topics: Acetamides; Adult; Aged; Antitubercular Agents; Clofazimine; Drug Therapy, Combination; Female; Humans; Linezolid; Logistic Models; Male; Middle Aged; Odds Ratio; Oxazolidinones; Risk Factors; Time Factors; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Young Adult | 2013 |
Teeth and tongue discoloration after linezolid treatment in children.
Topics: Acetamides; Adolescent; Anti-Infective Agents; Bacterial Infections; Child; Child, Preschool; Female; Hospitalization; Humans; Linezolid; Male; Oxazolidinones; Tongue; Tooth Discoloration | 2013 |
Linezolid-induced hyperlactatemia in a burn patient.
Topics: Acetamides; Aged, 80 and over; Anti-Infective Agents; Burns; Female; Humans; Lactic Acid; Linezolid; Oxazolidinones; Skin Transplantation; Staphylococcal Infections | 2013 |
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.
Topics: Acetamides; Animals; Cardiolipins; Carrier Proteins; Cell Line; Cyclosporine; Enzyme Activation; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Interleukin-6; Linezolid; Macrophages; Mice; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Oxazolidinones; Potassium; Reactive Oxygen Species; Signal Transduction; Tumor Necrosis Factor-alpha | 2013 |
Cfr-mediated linezolid resistance in methicillin-resistant Staphylococcus aureus and Staphylococcus haemolyticus associated with clinical infections in humans: two case reports.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacterial Proteins; DNA Transposable Elements; DNA, Bacterial; Drug Resistance, Bacterial; Gene Order; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Plasmids; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus haemolyticus | 2014 |
Virulence and antibiotic resistance of Enterococcus faecalis clinical isolates recovered from three states of Mexico. Detection of linezolid resistance.
Topics: Acetamides; Anti-Infective Agents; Bacterial Proteins; Biofilms; Carrier Proteins; Drug Resistance, Microbial; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Linezolid; Membrane Proteins; Mexico; Oligopeptides; Oxazolidinones; Virulence; Virulence Factors | 2013 |
Development and validation of a new UPLC-PDA method to quantify linezolid in plasma and in dried plasma spots.
Topics: Acetamides; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Drug Monitoring; Drug Stability; Humans; Limit of Detection; Linear Models; Linezolid; Oxazolidinones; Reproducibility of Results | 2013 |
Emergence and long-lasting persistence of linezolid-resistant Enterococcus faecium-ST117 in an oncohematologic patient after a nine-day course of linezolid.
Topics: Acetamides; Acute Disease; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Leukemia; Linezolid; Male; Neutropenia; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S | 2014 |
Plasma exposure of free linezolid and its ratio to minimum inhibitory concentration varies in critically ill patients.
Topics: Acetamides; Administration, Intravenous; Aged; Anti-Bacterial Agents; Area Under Curve; Critical Illness; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Plasma; Staphylococcal Infections | 2013 |
Determinants of the species selectivity of oxazolidinone antibiotics targeting the large ribosomal subunit.
Topics: Acetamides; Anti-Infective Agents; Binding Sites; Deinococcus; Drug Delivery Systems; Haloarcula marismortui; Linezolid; Molecular Dynamics Simulation; Oxazolidinones; Ribosome Subunits, Large, Bacterial; Species Specificity | 2013 |
Molecular characterization and antibiotic resistance of clinical isolates of methicillin-resistant Staphylococcus aureus obtained from Southeast of Iran (Kerman).
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Child; Child, Preschool; Ciprofloxacin; Clindamycin; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Erythromycin; Exotoxins; Gentamicins; Humans; Infant; Iran; Leukocidins; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Micrococcal Nuclease; Middle Aged; Oxazolidinones; Penicillin-Binding Proteins; Phenotype; Prevalence; Staphylococcal Infections; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin; Young Adult | 2014 |
Comparative evaluation of serotonin toxicity among veterans affairs patients receiving linezolid and vancomycin.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents; Antiemetics; Bacterial Infections; Cohort Studies; Drug Interactions; Female; Histamine Antagonists; Humans; Linezolid; Male; Middle Aged; New York; Oxazolidinones; Serotonin; Vancomycin; Veterans; Veterans Health | 2013 |
Simultaneous quantification of linezolid, tinidazole, norfloxacin, moxifloxacin, levofloxacin, and gatifloxacin in human plasma for therapeutic drug monitoring and pharmacokinetic studies in human volunteers.
Topics: Acetamides; Adult; Anti-Infective Agents; Aza Compounds; Chromatography, High Pressure Liquid; Drug Monitoring; Fluoroquinolones; Gatifloxacin; Humans; Levofloxacin; Limit of Detection; Linezolid; Male; Moxifloxacin; Norfloxacin; Oxazolidinones; Quinolines; Reproducibility of Results; Sensitivity and Specificity; Tinidazole; Young Adult | 2013 |
Activity of linezolid and daptomycin against methicillin-resistant coagulase-negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients.
Topics: Acetamides; Anti-Bacterial Agents; Child; Coagulase; Daptomycin; Dose-Response Relationship, Drug; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Structure-Activity Relationship; Vancomycin | 2014 |
Pancytopenia and lactic acidosis associated with linezolid use in a patient with empyema.
Topics: Acetamides; Acidosis, Lactic; Adult; Anti-Infective Agents; Empyema, Pleural; Humans; Linezolid; Male; Oxazolidinones; Pancytopenia | 2013 |
Antibiotic-induced autoactivation of IS256 in Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Chloramphenicol; DNA Transposable Elements; Gene Expression Regulation, Bacterial; Linezolid; Mutation; Oxazolidinones; Spectinomycin; Staphylococcus aureus; Temperature | 2013 |
Linezolid-induced optic neuropathy.
Topics: Acetamides; Anti-Infective Agents; Diagnosis, Differential; Humans; Linezolid; Male; Middle Aged; Optic Nerve; Optic Nerve Diseases; Oxazolidinones; RNA, Ribosomal, 23S; Tomography, Optical Coherence; Visual Acuity | 2014 |
Biliary pharmacodynamic exposure to linezolid in two liver transplant patients.
Topics: Acetamides; Bile; Biomarkers; Humans; Linezolid; Liver Transplantation; Oxazolidinones | 2014 |
Linezolid resistance in Enterococcus faecium isolated in Ontario, Canada.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecium; Female; Genes, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Methyltransferases; Microbial Sensitivity Tests; Middle Aged; Multilocus Sequence Typing; Mutation; Ontario; Oxazolidinones | 2013 |
Novel promising linezolid analogues: rational design, synthesis and biological evaluation.
Topics: Acetamides; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Design; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Staphylococcus aureus; Structure-Activity Relationship | 2013 |
Glans necrosis produced by trauma during masturbation.
Topics: Acetamides; Anti-Infective Agents; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Masturbation; Middle Aged; Necrosis; Oxazolidinones; Penis; Tomography, X-Ray Computed; Treatment Outcome | 2013 |
Activities of fosfomycin and rifampin on planktonic and adherent Enterococcus faecalis strains in an experimental foreign-body infection model.
Topics: Acetamides; Ampicillin; Animals; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Calorimetry; Daptomycin; Disease Models, Animal; Drug Therapy, Combination; Enterococcus faecalis; Foreign Bodies; Fosfomycin; Gentamicins; Gram-Positive Bacterial Infections; Guinea Pigs; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Rifampin; Vancomycin | 2014 |
[Retrospective analysis of the Gram-positive bacteria-infected cases in the Department of Hematology].
Topics: Acetamides; Adult; Aged; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Teicoplanin; Vancomycin | 2013 |
Quantification of linezolid in serum by LC-MS/MS using semi-automated sample preparation and isotope dilution internal standardization.
Topics: Acetamides; Analytic Sample Preparation Methods; Automation; Blood Chemical Analysis; Chromatography, Liquid; Humans; Linezolid; Oxazolidinones; Radioisotope Dilution Technique; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry | 2014 |
Secretory ranalexin produced in recombinant Pichia pastoris exhibits additive or synergistic bactericidal activity when used in combination with polymyxin B or linezolid against multi-drug resistant bacteria.
Topics: Acetamides; Amphibian Proteins; Anti-Bacterial Agents; Bioengineering; Drug Synergism; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Peptides, Cyclic; Pichia; Polymyxin B; Recombinant Proteins | 2014 |
Linezolid induces ring sideroblasts.
Topics: Acetamides; Adult; Aged; Anemia, Sideroblastic; Anti-Infective Agents; Bone Marrow Cells; Cohort Studies; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies | 2013 |
Antimicrobial properties and elution kinetics of linezolid from polymethylmethacrylate.
Topics: Acetamides; Aminoglycosides; Anti-Infective Agents; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Polymethacrylic Acids | 2013 |
Ineffectiveness of daptomycin in the treatment of septic pulmonary emboli and persistent bacteremia caused by methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacteremia; Daptomycin; Fatal Outcome; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pulmonary Embolism; Staphylococcal Infections; Treatment Failure; Vancomycin | 2013 |
Susceptibility profiles of Nocardia isolates based on current taxonomy.
Topics: Acetamides; Amikacin; Anti-Bacterial Agents; Ceftriaxone; Drug Resistance, Bacterial; Humans; Imipenem; Linezolid; Microbial Sensitivity Tests; Nocardia; Nocardia Infections; Oxazolidinones; Phylogeny; Species Specificity; Trimethoprim, Sulfamethoxazole Drug Combination | 2014 |
[Drug sensitivity analysis of Mycobacterium chelonae and Mycobacterium abscessus and evaluation of Etest for susceptibility testing].
Topics: Acetamides; Amikacin; Anti-Bacterial Agents; Cefoxitin; Clarithromycin; Culture Media; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Oxazolidinones; Sensitivity and Specificity; Tobramycin | 2013 |
In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Clostridioides difficile; Clostridium Infections; Cricetinae; Enterocolitis, Pseudomembranous; Enterotoxins; Female; Fluoroquinolones; Humans; Linezolid; Male; Metronidazole; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Oxazolidinones; Spores, Bacterial; Survival Analysis; Vancomycin | 2014 |
Investigations of the mode of action and resistance development of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Clostridioides difficile; DNA Gyrase; Drug Resistance, Bacterial; Fidaxomicin; Fluoroquinolones; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Protein Biosynthesis; Recombinant Proteins; RNA; Subcellular Fractions; Transcription, Genetic; Vancomycin | 2014 |
A practical guide to community-acquired MRSA.
Topics: Acetamides; Administration, Topical; Anti-Bacterial Agents; Clindamycin; Community-Acquired Infections; Continuity of Patient Care; Cross Infection; Ethnicity; Humans; Linezolid; Medical History Taking; Methicillin-Resistant Staphylococcus aureus; Mupirocin; Oxazolidinones; Patient Education as Topic; Physical Examination; Practice Guidelines as Topic; Rifampin; Risk Factors; Secondary Prevention; Skin; Staphylococcal Infections; Trimethoprim, Sulfamethoxazole Drug Combination | 2013 |
Activity of linezolid-containing regimens against multidrug-resistant tuberculosis in mice.
Topics: Acetamides; Animals; Antitubercular Agents; Bacterial Load; Colony Count, Microbial; Disease Models, Animal; Drug Therapy, Combination; Humans; Interferon-gamma; Interleukin-10; Linezolid; Lung; Male; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Oxazolidinones; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2014 |
Therapeutic drug management: is it the future of multidrug-resistant tuberculosis treatment?
Topics: Acetamides; Antitubercular Agents; Clarithromycin; Female; Humans; Linezolid; Male; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2013 |
Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Bacterial Toxins; Bronchoalveolar Lavage Fluid; Chemokines; Drug Synergism; Drug Therapy, Combination; Female; Hemolysin Proteins; Immunization, Passive; Kidney; Linezolid; Lung; Mice; Mice, Inbred C57BL; Oxazolidinones; Pneumonia, Staphylococcal; Staphylococcus aureus; Survival Analysis; Vancomycin | 2014 |
Enhanced cellular uptake by "pharmaceutically oriented devices" of new simplified analogs of Linezolid with antimicrobial activity.
Topics: Acetamides; Anti-Infective Agents; Drug Delivery Systems; Emulsions; Escherichia coli; Linezolid; Microbial Sensitivity Tests; Nanoparticles; Oxazolidinones; Polymers; Saccharomyces cerevisiae | 2014 |
Study on interaction between palladium(ІІ)-Linezolid chelate with eosin by resonance Rayleigh scattering, second order of scattering and frequency doubling scattering methods using Taguchi orthogonal array design.
Topics: Acetamides; Analysis of Variance; Chelating Agents; Eosine Yellowish-(YS); Humans; Light; Linezolid; Models, Molecular; Oxazolidinones; Palladium; Reference Standards; Reproducibility of Results; Scattering, Radiation; Signal-To-Noise Ratio; Spectrum Analysis; Tablets | 2014 |
Out-of-pocket costs and prescription reversals with oral linezolid.
Topics: Acetamides; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Databases, Factual; Drug Substitution; Financing, Personal; Health Maintenance Organizations; Humans; Linear Models; Linezolid; Medicare Part D; Middle Aged; Oxazolidinones; Patient Readmission; Pneumonia, Bacterial; Retrospective Studies; Soft Tissue Infections; United States; Young Adult | 2013 |
Summary of linezolid activity and resistance mechanisms detected during the 2012 LEADER surveillance program for the United States.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Epidemiological Monitoring; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Streptococcus; United States | 2014 |
Monte Carlo simulation analysis of ceftobiprole, dalbavancin, daptomycin, tigecycline, linezolid and vancomycin pharmacodynamics against intensive care unit-isolated methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Computer Simulation; Cross Infection; Daptomycin; Dose-Response Relationship, Drug; Humans; Intensive Care Units; Linezolid; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Minocycline; Models, Biological; Monte Carlo Method; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Tigecycline; Vancomycin | 2014 |
Outcomes of MDR/XDR-TB patients treated with linezolid: experience in Thailand.
Topics: Acetamides; Adult; Anti-Infective Agents; Antitubercular Agents; Capreomycin; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Female; Humans; Linezolid; Male; Middle Aged; Off-Label Use; Oxazolidinones; Retrospective Studies; Thailand; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2013 |
Linezolid use in hospitalized children.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Drug Prescriptions; Female; Hospitalization; Humans; Infant; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Staphylococcal Infections | 2014 |
Rapid identification of linezolid resistance in Enterococcus spp. based on high-resolution melting analysis.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Linezolid; Oxazolidinones; Polymorphism, Genetic; RNA, Bacterial; RNA, Ribosomal, 23S | 2014 |
Upregulation of icaA, atlE and aap genes by linezolid but not vancomycin in Staphylococcus epidermidis RP62A biofilms.
Topics: Acetamides; Anti-Bacterial Agents; Biofilms; Gene Expression Profiling; Genes, Bacterial; Linezolid; Oxazolidinones; Real-Time Polymerase Chain Reaction; Staphylococcus epidermidis; Transcriptional Activation; Up-Regulation; Vancomycin | 2014 |
Comparative cost-effectiveness of alternative empiric antimicrobial treatment options for suspected enterococcal bacteremia.
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Cost-Benefit Analysis; Daptomycin; Decision Support Techniques; Drug Resistance, Bacterial; Enterococcus; Humans; Linezolid; Models, Economic; Monte Carlo Method; Oxazolidinones; Quality-Adjusted Life Years; Vancomycin | 2014 |
Activity of ceftobiprole against methicillin-resistant Staphylococcus aureus strains with reduced susceptibility to daptomycin, linezolid or vancomycin, and strains with defined SCCmec types.
Topics: Acetamides; Anti-Bacterial Agents; Cephalosporins; Daptomycin; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Vancomycin | 2014 |
Pharmacological properties of NAI-603, a well-tolerated semisynthetic derivative of ramoplanin.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Depsipeptides; Enterococcus; Female; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Vancomycin | 2014 |
Comparative effectiveness of linezolid and vancomycin among a national veterans affairs cohort with methicillin-resistant Staphylococcus aureus pneumonia.
Topics: Acetamides; Administration, Oral; Aged; Anti-Bacterial Agents; Databases, Factual; Electronic Health Records; Female; Humans; Injections, Intravenous; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Bacterial; Propensity Score; Proportional Hazards Models; Retrospective Studies; Treatment Outcome; Vancomycin; Veterans | 2014 |
Optic neuropathy secondary to Linezolid for multidrug-resistant mycobacterial spinal tuberculosis.
Topics: Acetamides; Anti-Infective Agents; Humans; Linezolid; Male; Optic Nerve Diseases; Oxazolidinones; Tuberculosis, Multidrug-Resistant; Tuberculosis, Spinal; Young Adult | 2015 |
Beijing genotype of Mycobacterium tuberculosis is significantly associated with linezolid resistance in multidrug-resistant and extensively drug-resistant tuberculosis in China.
Topics: Acetamides; Antitubercular Agents; China; Drug Resistance, Multiple, Bacterial; Genotype; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Epidemiology; Molecular Typing; Mutation; Mycobacterium tuberculosis; Oxazolidinones; Prevalence; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Tuberculosis, Multidrug-Resistant | 2014 |
Genotypically different clones of Staphylococcus aureus are diverse in the antimicrobial susceptibility patterns and biofilm formations.
Topics: Acetamides; Anti-Infective Agents; Biofilms; Daptomycin; Genetic Variation; Genotype; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Viability; Minocycline; Oxazolidinones; Staphylococcal Infections; Tigecycline; Vancomycin | 2013 |
Zyvox® Annual Appraisal of Potency and Spectrum (ZAAPS) program: report of linezolid activity over 9 years (2004-12).
Topics: Acetamides; Anti-Infective Agents; Global Health; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Population Surveillance | 2014 |
Impact of vancomycin or linezolid therapy on development of renal dysfunction and thrombocytopenia in Japanese patients.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Asian People; Drug Monitoring; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Platelet Count; Renal Insufficiency; Retrospective Studies; Thrombocytopenia; Time Factors; Vancomycin; Young Adult | 2013 |
Mutations within the rplD Gene of Linezolid-Nonsusceptible Streptococcus pneumoniae Strains Isolated in the United States.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Linezolid; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Streptococcus pneumoniae; United States | 2014 |
Clinical population pharmacokinetics and toxicodynamics of linezolid.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Prospective Studies; Young Adult | 2014 |
Therapeutic drug monitoring and receiver operating characteristic curve prediction may reduce the development of linezolid-associated thrombocytopenia in critically ill patients.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Critical Illness; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Risk Factors; ROC Curve; Thrombocytopenia; Young Adult | 2014 |
In vitro activity of fosfomycin in combination with linezolid against clinical isolates of methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Drug Combinations; Drug Synergism; Fosfomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections | 2014 |
A man in his seventies with a long-term infection and severe acid-base imbalance.
Topics: Acetamides; Acidosis, Lactic; Aged; Anti-Infective Agents; Critical Illness; Hemodiafiltration; Humans; Linezolid; Liver Failure; Male; Oxazolidinones; Renal Insufficiency; Sepsis; Toes | 2014 |
Antimicrobial synergism against different lineages of methicillin-resistant Staphylococcus aureus carrying SCCmec IV.
Topics: Acetamides; Anti-Bacterial Agents; Biofilms; Biomass; Drug Synergism; Gentamicins; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microbial Viability; Oxazolidinones; Rifampin; Vancomycin | 2014 |
Which antibiotic for hospital acquired pneumonia caused by MRSA?
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Cross Infection; Daptomycin; Humans; Linezolid; Lipoglycopeptides; Methicillin-Resistant Staphylococcus aureus; Minocycline; Oxazolidinones; Pneumonia, Staphylococcal; Tigecycline; Vancomycin; Virginiamycin | 2014 |
Staphylococcus aureus toxic shock syndrome toxin-1 endocarditis with muscular metastatic abscesses.
Topics: Abscess; Acetamides; Adult; Anti-Bacterial Agents; Bacterial Toxins; Daptomycin; Endocarditis, Bacterial; Enterotoxins; Female; Humans; Linezolid; Muscular Diseases; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Superantigens | 2014 |
Reduction of linezolid-associated thrombocytopenia by the dose adjustment based on the risk factors such as basal platelet count and body weight.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Body Weight; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Platelet Count; Regression Analysis; Risk Factors; Thrombocytopenia | 2014 |
[Vancomycin resistant Staphylococcus epidermidis caused prosthesis infection. Linezolid and rifampicin healed the complicated infection].
Topics: Acetamides; Anti-Bacterial Agents; Humans; Knee Prosthesis; Linezolid; Male; Middle Aged; Oxazolidinones; Prosthesis-Related Infections; Rifampin; Staphylococcal Infections; Staphylococcus epidermidis; Treatment Outcome; Vancomycin; Vancomycin Resistance | 2014 |
What is the place of linezolid in the treatment of methicillin-resistant Staphylococcus aureus nosocomial pneumonia and complicated skin and soft tissue infections in Europe?
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Europe; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Soft Tissue Infections; Staphylococcal Skin Infections | 2014 |
Bacteriophage mediated killing of Staphylococcus aureus in vitro on orthopaedic K wires in presence of linezolid prevents implant colonization.
Topics: Acetamides; Analysis of Variance; Arthroplasty; Bacteriophages; Bone Wires; Combined Modality Therapy; Fluorescence; Humans; Hypromellose Derivatives; Linezolid; Methicillin-Resistant Staphylococcus aureus; Methylcellulose; Microscopy, Electron, Scanning; Oxazolidinones; Staphylococcal Infections | 2014 |
Developments in the pharmacokinetic/pharmacodynamic index of linezolid: a step toward dose optimization using Monte Carlo simulation in critically ill patients.
Topics: Acetamides; Anti-Bacterial Agents; Area Under Curve; Computer Simulation; Critical Illness; Drug Dosage Calculations; Drug Resistance, Multiple, Bacterial; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Models, Statistical; Monte Carlo Method; Oxazolidinones; Streptococcus pneumoniae | 2014 |
Linezolid resistance in vancomycin-resistant Enterococcus faecalis and Enterococcus faecium isolates in a Brazilian hospital.
Topics: Acetamides; Brazil; Enterococcus faecalis; Enterococcus faecium; Hospitals; Linezolid; Oxazolidinones; Vancomycin; Vancomycin-Resistant Enterococci | 2014 |
Linezolid dampens neutrophil-mediated inflammation in methicillin-resistant Staphylococcus aureus-induced pneumonia and protects the lung of associated damages.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Antigens, Ly; Bacterial Load; Cytokines; Disease Models, Animal; Endothelial Cells; Immunologic Factors; Injections, Subcutaneous; Linezolid; Lung; Methicillin-Resistant Staphylococcus aureus; Mice; Neutrophils; Oxazolidinones; Peroxidase; Pneumonia, Staphylococcal; Vancomycin | 2014 |
Molecular epidemiology of methicillin-resistant S. aureus in the ICU setting.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Genotyping Techniques; Humans; Intensive Care Units; Italy; Linezolid; Methicillin-Resistant Staphylococcus aureus; Molecular Epidemiology; Oxazolidinones; Staphylococcal Infections; Vancomycin | 2014 |
An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria.
Topics: Acetamides; Acinetobacter baumannii; Anthracyclines; Anti-Bacterial Agents; DNA-Directed RNA Polymerases; Drug Synergism; Escherichia coli; Linezolid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxazolidinones; Rifampin; Streptomyces; Structure-Activity Relationship | 2014 |
Treatment of multidrug-resistant and extensively drug-resistant tuberculosis in adolescent patients.
Topics: Acetamides; Adolescent; Antitubercular Agents; Child; Extensively Drug-Resistant Tuberculosis; Female; Humans; Linezolid; Male; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2014 |
Linezolid underexposure in a hypothyroid patient on levothyroxine replacement therapy: a case report.
Topics: Acetamides; Adult; Anti-Infective Agents; Drug Interactions; Female; Humans; Hypothyroidism; Linezolid; Oxazolidinones; Soft Tissue Infections; Thyroxine | 2014 |
In vitro and in vivo activities of three oxazolidinones against nonreplicating Mycobacterium tuberculosis.
Topics: Acetamides; Animals; Antitubercular Agents; Cells, Cultured; Colony Count, Microbial; Female; Hypoxia; Latent Tuberculosis; Linezolid; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones | 2014 |
Spectrofluorimetric determination of gemifloxacin mesylate and linezolid in pharmaceutical formulations: Application of quinone-based fluorophores and enhanced native fluorescence.
Topics: Acetamides; Chemistry, Pharmaceutical; Fluoroquinolones; Gemifloxacin; Linezolid; Naphthyridines; Oxazolidinones; Quinones; Spectrometry, Fluorescence | 2014 |
Two and three way spectrophotometric-assisted multivariate determination of linezolid in the presence of its alkaline and oxidative degradation products and application to pharmaceutical formulation.
Topics: Acetamides; Linezolid; Oxazolidinones; Spectrophotometry | 2014 |
Effect of linezolid on hematological and oxidative parameters in rats.
Topics: Acetamides; Animals; Antioxidants; Blood Cell Count; Blood Cells; Free Radicals; Linezolid; Lipid Peroxidation; Male; Nitric Oxide; Oxazolidinones; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vitamin E | 2014 |
Linezolid minimum inhibitory concentration (MIC) creep in methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates at a single Japanese center.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Japan; Linear Models; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Time Factors | 2014 |
Comparison of commercial antimicrobial susceptibility test methods for testing of Staphylococcus aureus and Enterococci against vancomycin, daptomycin, and linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Enterococcus; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Vancomycin | 2014 |
Comparison of M.I.C.E. and Etest with CLSI agar dilution for antimicrobial susceptibility testing against oxacillin-resistant Staphylococcus spp.
Topics: Acetamides; Agar; Anti-Infective Agents; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxacillin; Oxazolidinones; Regression Analysis; Reproducibility of Results; Staphylococcus; Teicoplanin; Vancomycin | 2014 |
Linezolid-Resistant Staphylococcus epidermidis, Portugal, 2012.
Topics: Acetamides; Anti-Infective Agents; Cross Infection; Drug Resistance, Bacterial; Hospitals; Humans; Linezolid; Microbial Sensitivity Tests; Multilocus Sequence Typing; Mutation; Oxazolidinones; Portugal; Staphylococcal Infections; Staphylococcus epidermidis | 2014 |
[Pattern dynamics of bacteriemia and sepsis pathogens in ICU patients of emergency service].
Topics: Acetamides; Acinetobacter; Anti-Bacterial Agents; Bacteremia; beta-Lactamases; Candida; Candidiasis; Carbapenems; Cefoperazone; Drug Resistance, Multiple, Bacterial; Enterococcus; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Klebsiella pneumoniae; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Sepsis; Sulbactam; Vancomycin | 2013 |
Methicillin-resistant Staphylococcus aureus-related septic pulmonary embolism and sacroiliitis treated with long-term linezolid in a patient with adult-onset Still's disease.
Topics: Acetamides; Anti-Infective Agents; Female; Follow-Up Studies; Humans; Linezolid; Magnetic Resonance Imaging; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pulmonary Embolism; RNA, Ribosomal, 23S; Sacroiliitis; Staphylococcal Infections; Still's Disease, Adult-Onset; Time Factors; Tomography, X-Ray Computed; Young Adult | 2014 |
In vitro synergy between linezolid and clarithromycin against Mycobacterium tuberculosis.
Topics: Acetamides; Anti-Bacterial Agents; Biological Specimen Banks; Clarithromycin; Drug Resistance, Bacterial; Drug Synergism; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2014 |
Oxazolidinone derivatives: cytoxazone-linezolid hybrids induces apoptosis and senescence in DU145 prostate cancer cells.
Topics: Acetamides; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cellular Senescence; Humans; Linezolid; Male; Membrane Potential, Mitochondrial; Oxazoles; Oxazolidinones; Prostatic Neoplasms | 2014 |
Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism.
Topics: Acetamides; Acidosis, Lactic; Adult; Aged; DNA, Mitochondrial; Female; Genetic Predisposition to Disease; Humans; Linezolid; Liver Transplantation; Male; Mitochondria; Nocardia asteroides; Nocardia Infections; Oxazolidinones; Polymorphism, Single Nucleotide; RNA, Ribosomal, 16S; Tuberculosis, Pulmonary | 2014 |
Complete genome sequencing and comparative analysis of the linezolid-resistant Enterococcus faecalis strain DENG1.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Genome, Bacterial; Linezolid; Oxazolidinones; Phylogeny; Species Specificity; Virulence Factors | 2014 |
Local delivery of linezolid from poly-D,L-lactide (PDLLA)-linezolid-coated orthopaedic implants to prevent MRSA mediated post-arthroplasty infections.
Topics: Acetamides; Anti-Bacterial Agents; Arthroplasty; Bacterial Adhesion; Coated Materials, Biocompatible; Drug Carriers; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Polyesters; Prostheses and Implants; Prosthesis-Related Infections; Staphylococcal Infections | 2014 |
Preventing intraperitoneal adhesions with linezolid and hyaluronic acid/carboxymethylcellulose: a comparative study in cecal abrasion model.
Topics: Acetamides; Animals; Anti-Infective Agents; Biocompatible Materials; Carboxymethylcellulose Sodium; Cecum; Female; Hyaluronic Acid; Injections, Intraperitoneal; Linezolid; Oxazolidinones; Peritoneal Diseases; Postoperative Complications; Random Allocation; Rats; Rats, Wistar; Tissue Adhesions; Treatment Outcome | 2014 |
Immunomodulatory effect of linezolid on methicillin-resistant Staphylococcus aureus supernatant-induced MUC5AC overexpression in human airway epithelial cells.
Topics: Acetamides; Anti-Bacterial Agents; Cell Line; Cytokines; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mucin 5AC; Mucin-5B; Oxazolidinones; Phosphorylation; Respiratory Mucosa; RNA, Messenger | 2014 |
A cfr-positive clinical staphylococcal isolate from India with multiple mechanisms of linezolid-resistance.
Topics: Acetamides; Bacterial Proteins; Base Sequence; Computational Biology; DNA Primers; Drug Resistance, Bacterial; Linezolid; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Oxazolidinones; RNA, Ribosomal, 16S; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcus haemolyticus | 2014 |
In vitro activity of telavancin compared with vancomycin and linezolid against Gram-positive organisms isolated from cancer patients.
Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Lipoglycopeptides; Microbial Sensitivity Tests; Neoplasms; Oxazolidinones; Vancomycin | 2014 |
Prevalence and detection of mixed-population enterococcal bacteremia.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacteremia; Coinfection; Daptomycin; Enterococcus faecalis; Enterococcus faecium; Gentamicins; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Multilocus Sequence Typing; Oxazolidinones; Prevalence; Treatment Outcome; Vancomycin Resistance | 2014 |
Antibiotic regimens with rifampicin for treatment of Enterococcus faecium in biofilms.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Bone Cements; Daptomycin; Drug Combinations; Drug Resistance, Bacterial; Enterococcus faecium; Linezolid; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Rifampin; Tigecycline | 2014 |
Berberine enhances the antibacterial activity of selected antibiotics against coagulase-negative Staphylococcus strains in vitro.
Topics: Acetamides; Anti-Bacterial Agents; Berberine; Coagulase; Drug Synergism; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Staphylococcus epidermidis | 2014 |
Activity of daptomycin or linezolid in combination with rifampin or gentamicin against biofilm-forming Enterococcus faecalis or E. faecium in an in vitro pharmacodynamic model using simulated endocardial vegetations and an in vivo survival assay using Gal
Topics: Acetamides; Animals; Anti-Bacterial Agents; Biofilms; Colony Count, Microbial; Daptomycin; Drug Interactions; Drug Therapy, Combination; Enterococcus faecalis; Enterococcus faecium; Gentamicins; Humans; Larva; Linezolid; Microbial Sensitivity Tests; Models, Biological; Models, Statistical; Moths; Oxazolidinones; Rifampin | 2014 |
[Isolated tricuspid valve infective endocarditis in a patient with a urological history].
Topics: Acetamides; Endocarditis, Bacterial; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Papilloma; Streptococcal Infections; Tricuspid Valve; Ultrasonography; Urinary Bladder Neoplasms; Urologic Surgical Procedures | 2014 |
Linezolid-dependent function and structure adaptation of ribosomes in a Staphylococcus epidermidis strain exhibiting linezolid dependence.
Topics: Acetamides; Adaptation, Physiological; Anti-Bacterial Agents; Centrifugation, Density Gradient; Drug Resistance, Bacterial; Kinetics; Linezolid; Oxazolidinones; Peptidyl Transferases; Protein Biosynthesis; Ribosomal Proteins; Ribosomes; Staphylococcus epidermidis | 2014 |
Linezolid in the treatment of extensively drug-resistant tuberculosis.
Topics: Acetamides; Adolescent; Adult; Aged; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones; Retrospective Studies; Treatment Outcome; Young Adult | 2014 |
Linezolid in the treatment of drug-resistant tuberculosis: the way forward?
Topics: Acetamides; Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Mycobacterium tuberculosis; Oxazolidinones; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2014 |
In vitro activities of oritavancin and comparators against meticillin-resistant Staphylococcus aureus (MRSA) isolates harbouring the novel mecC gene.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Daptomycin; Gene Expression; Glycopeptides; Linezolid; Lipoglycopeptides; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microbial Viability; Oxazolidinones; Vancomycin | 2014 |
New antibiotics for skin and skin-structure infections.
Topics: Acetamides; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial | 2014 |
Retrospective analysis of the risk factors for linezolid-induced thrombocytopenia in adult Japanese patients.
Topics: Acetamides; Age Factors; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Hospitals, District; Humans; Incidence; Infections; Japan; Linezolid; Male; Middle Aged; Oxazolidinones; Platelet Count; Platelet Transfusion; Renal Insufficiency; Retrospective Studies; Risk Factors; Tertiary Care Centers; Thrombocytopenia | 2014 |
Rational development and validation of a new microbiological assay for linezolid and its measurement uncertainty.
Topics: Acetamides; Anti-Bacterial Agents; Biological Assay; Culture Media; Linezolid; Oxazolidinones; Reproducibility of Results; Staphylococcus aureus; Uncertainty | 2014 |
Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing.
Topics: Acetamides; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Proteins; Blood; Coagulase; Drug Resistance, Bacterial; Female; Genome, Bacterial; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus; Staphylococcus epidermidis; Young Adult | 2014 |
Higher clinical success in patients with ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus treated with linezolid compared with vancomycin: results from the IMPACT-HAP study.
Topics: Acetamides; Adult; Anemia; Anti-Bacterial Agents; APACHE; Female; Humans; Kidney Diseases; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Ventilator-Associated; Retrospective Studies; Thrombocytopenia; Treatment Outcome; Vancomycin | 2014 |
Antibiotic treatment patterns across Europe in patients with complicated skin and soft-tissue infections due to meticillin-resistant Staphylococcus aureus: a plea for implementation of early switch and early discharge criteria.
Topics: Acetamides; Administration, Oral; Adult; Aged; Anti-Bacterial Agents; Drug Administration Schedule; Europe; Female; Hospitalization; Humans; Injections, Intravenous; Length of Stay; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Patient Discharge; Practice Guidelines as Topic; Retrospective Studies; Soft Tissue Infections; Staphylococcal Skin Infections; Vancomycin | 2014 |
Linezolid-induced lactic acidosis corrected with sustained low-efficiency dialysis: a case report.
Topics: Acetamides; Acidosis, Lactic; Anti-Infective Agents; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Renal Dialysis | 2014 |
Hypoglycemia in patients treated with linezolid.
Topics: Acetamides; Aged; Aged, 80 and over; Anti-Bacterial Agents; Child; Female; Humans; Hypoglycemia; Linezolid; Male; Middle Aged; Oxazolidinones; United States | 2014 |
[In vitro antimicrobial susceptibility in Enterococcus faecalis and Enterococcus faecium isolated from hospitalized patients].
Topics: Acetamides; Bacterial Typing Techniques; Cross Infection; Cuba; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Hospitals, Urban; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Tertiary Care Centers; Vancomycin Resistance | 2014 |
[Macrolide and linezolid susceptibility testing for Mycobacterium intracellulare isolates].
Topics: Acetamides; Humans; Linezolid; Macrolides; Microbial Sensitivity Tests; Mycobacterium avium Complex; Oxazolidinones | 2014 |
Experimental study of the efficacy of linezolid alone and in combinations against experimental meningitis due to Staphylococcus aureus strains with decreased susceptibility to beta-lactams and glycopeptides.
Topics: Acetamides; Animals; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactams; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Glycopeptides; Linezolid; Meningitis, Bacterial; Microbial Sensitivity Tests; Oxazolidinones; Rabbits; Random Allocation; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Vancomycin | 2014 |
Linezolid optic neuropathy: be careful and quick.
Topics: Acetamides; Adult; Anti-Infective Agents; Female; Humans; Linezolid; Male; Middle Aged; Optic Nerve Diseases; Oxazolidinones; Young Adult | 2013 |
Efficacy of the novel oxazolidinone compound FYL-67 for preventing biofilm formation by Staphylococcus aureus.
Topics: Acetamides; Animals; Anti-Infective Agents; Biofilms; Linezolid; Male; Mice; Mice, Inbred C57BL; Oxazolidinones; Staphylococcus aureus; Treatment Outcome | 2014 |
The effect of inoculum size on selection of in vitro resistance to vancomycin, daptomycin, and linezolid in methicillin-resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Multiple, Bacterial; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Vancomycin | 2014 |
Modeling economic implications of alternative treatment strategies for acute bacterial skin and skin structure infections.
Topics: Acetamides; Acute Disease; Administration, Intravenous; Anti-Bacterial Agents; Daptomycin; Health Expenditures; Humans; Linezolid; Oxazolidinones; Patient Discharge; Skin Diseases, Bacterial; Soft Tissue Infections; United States; Vancomycin | 2014 |
Factors influencing linezolid-nonsusceptible coagulase-negative staphylococci dissemination among patients in the intensive care unit: a retrospective cohort study.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Coagulase; Cohort Studies; Female; Humans; Intensive Care Units; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Oxazolidinones; Phenotype; Retrospective Studies; Risk Factors; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus | 2013 |
Binding properties of antimicrobial agents to lipid membranes using surface plasmon resonance.
Topics: Acetamides; Anti-Infective Agents; Cell Membrane; Erythromycin; Linezolid; Membrane Lipids; Oxazolidinones; Surface Plasmon Resonance; Teicoplanin; Vancomycin | 2014 |
Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis.
Topics: Acetamides; Adult; Antitubercular Agents; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Treatment Outcome; Tuberculosis, Meningeal | 2014 |
In vitro antimicrobial activity of the novel oxazolidinone tedizolid and comparator agents against Staphylococcus aureus and linezolid-resistant Gram-positive pathogens: a multicentre study in China.
Topics: Acetamides; China; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Oxazolidinones; Staphylococcus aureus | 2014 |
Analysis of thrombocytopenic effects and population pharmacokinetics of linezolid: a dosage strategy according to the trough concentration target and renal function in adult patients.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Area Under Curve; Female; Humans; Linezolid; Male; Metabolic Clearance Rate; Microbial Sensitivity Tests; Middle Aged; Models, Statistical; Oxazolidinones; Plasma; Thrombocytopenia | 2014 |
Risk factors for linezolid-associated thrombocytopenia in adult patients.
Topics: Acetamides; Aged; Aged, 80 and over; Analysis of Variance; Body Weight; Female; Humans; Japan; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Thrombocytopenia | 2014 |
Cluster of linezolid-resistant Enterococcus faecium ST117 in Norwegian hospitals.
Topics: Acetamides; Adult; Aged, 80 and over; Anti-Bacterial Agents; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Hospitals; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Typing; Norway; Oxazolidinones; Point Mutation; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Virulence Factors | 2014 |
Antimicrobial stewardship and linezolid.
Topics: Acetamides; Anti-Infective Agents; Drug Utilization Review; Humans; Inappropriate Prescribing; Linezolid; Off-Label Use; Oxazolidinones; Retrospective Studies | 2014 |
Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Clindamycin; Diterpenes; Drug Resistance, Multiple, Bacterial; Gene Transfer Techniques; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Sequence Data; New York; Organophosphates; Oxazoles; Oxazolidinones; Plasmids; Staphylococcal Infections; Thiamphenicol | 2014 |
Optimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol.
Topics: Acetamides; Aerosols; Anti-Bacterial Agents; Daptomycin; Equipment Design; Linezolid; Nebulizers and Vaporizers; Oxazolidinones; Particle Size; Vancomycin | 2014 |
Linezolid-resistant Staphylococcus aureus strain 1128105, the first known clinical isolate possessing the cfr multidrug resistance gene.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Ceftazidime; Cystic Fibrosis; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Female; Genes, MDR; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Sequence Data; Multilocus Sequence Typing; Oxazolidinones; Plasmids; Pseudomonas aeruginosa; Pseudomonas Infections; Retrospective Studies; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcal Infections; Tobramycin | 2014 |
Experience with linezolid for the treatment of nocardiosis in organ transplant recipients.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Humans; Linezolid; Lung Transplantation; Male; Microbial Sensitivity Tests; Middle Aged; Nocardia; Nocardia Infections; Organ Transplantation; Oxazolidinones; Pennsylvania; Retrospective Studies; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination | 2015 |
Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation.
Topics: Acetamides; Anti-Bacterial Agents; Area Under Curve; Child; Child, Preschool; Drug Monitoring; Female; Gram-Positive Bacterial Infections; Hospitalization; Humans; Infant; Inpatients; Linezolid; Male; Monte Carlo Method; Oxazolidinones; Plasma; Retrospective Studies; Tertiary Care Centers | 2015 |
Random mutagenesis of the multidrug transporter AcrB from Escherichia coli for identification of putative target residues of efflux pump inhibitors.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Proteins; Linezolid; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Mutation; Oxazolidinones; Promoter Regions, Genetic; Protein Structure, Tertiary | 2014 |
Early lactic acidosis associated with linezolid therapy in paediatric patients.
Topics: Acetamides; Acidosis, Lactic; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Female; Gram-Positive Bacterial Infections; Humans; Infant; Linezolid; Male; Oxazolidinones; Time Factors; Treatment Outcome | 2014 |
Second-line drug susceptibilities of multidrug-resistant tuberculosis strains isolated in Thailand: an update.
Topics: Acetamides; Aminoglycosides; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Thailand; Tuberculosis, Multidrug-Resistant | 2014 |
A propensity score analysis shows that empirical treatment with linezolid does not increase the thirty-day mortality rate in patients with Gram-negative bacteremia.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Bacteremia; Empirical Research; Female; Glycopeptides; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Linezolid; Logistic Models; Male; Microbial Sensitivity Tests; Middle Aged; Odds Ratio; Oxazolidinones; Propensity Score; Survival Analysis | 2014 |
Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Central Nervous System Infections; Cerebrospinal Fluid; Critical Illness; Female; Humans; Linezolid; Male; Middle Aged; Neurosurgery; Oxazolidinones; Plasma; Prospective Studies | 2014 |
New insights into the in vitro susceptibility of Pythium insidiosum.
Topics: Acetamides; Anti-Bacterial Agents; Antifungal Agents; Azithromycin; Clarithromycin; Doxycycline; Linezolid; Microbial Sensitivity Tests; Minocycline; Mupirocin; Oxazolidinones; Pythium; Tigecycline | 2014 |
Colistin and anti-Gram-positive bacterial agents against Acinetobacter baumannii.
Topics: Acetamides; Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Colistin; Linezolid; Microbial Sensitivity Tests; Microscopy, Electron, Transmission; Oxazolidinones; Time Factors; Vancomycin | 2014 |
Evaluation of the treatment of methicillin-resistant Staphylococcus aureus bacteremia.
Topics: Acetamides; Adult; Aged; Anti-Bacterial Agents; Bacteremia; Daptomycin; Female; Health Care Costs; Hospitalization; Humans; Intensive Care Units; Length of Stay; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazolidinones; Retrospective Studies; Staphylococcal Infections; Tennessee; Treatment Outcome; Vancomycin | 2015 |
Use of linezolid susceptibility test results as a surrogate for the susceptibility of Gram-positive pathogens to tedizolid, a novel oxazolidinone.
Topics: Acetamides; Anti-Bacterial Agents; Biomarkers; Diagnostic Errors; Gram-Positive Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Oxazolidinones | 2014 |
[Elution properties of linezolid bone cement].
Topics: Acetamides; Anti-Bacterial Agents; Bone Cements; Humans; Linezolid; Male; Oxazolidinones | 2014 |
Linezolid-resistant Staphylococcus haemolyticus and Staphylococcus hominis: single and double mutations at the domain V of 23S rRNA among isolates from a Rio de Janeiro hospital.
Topics: Acetamides; Anti-Bacterial Agents; Brazil; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Hospitals; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus haemolyticus; Staphylococcus hominis | 2014 |
A 5-year survey of antimicrobial susceptibility profiles of methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients with bloodstream infections in Northeast Italy.
Topics: Acetamides; Anti-Bacterial Agents; Blood; Daptomycin; Health Surveys; Humans; Italy; Linezolid; Longitudinal Studies; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Oxazolidinones; Staphylococcal Infections; Teicoplanin; Tigecycline; Vancomycin | 2015 |
Linezolid dosage in pediatric patients based on pharmacokinetics and pharmacodynamics.
Topics: Acetamides; Child; Child, Preschool; Female; Glomerular Filtration Rate; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections | 2015 |
Fatal lactic acidosis associated with linezolid therapy.
Topics: Acetamides; Acidosis, Lactic; Aged; Anti-Infective Agents; Fatal Outcome; Humans; Linezolid; Male; Oxazolidinones; Surgical Wound Infection | 2015 |
Nonclinical and pharmacokinetic assessments to evaluate the potential of tedizolid and linezolid to affect mitochondrial function.
Topics: Animals; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Female; Humans; In Vitro Techniques; Linezolid; Male; Mice; Mitochondria; Mitochondrial Proteins; Monte Carlo Method; Neurotoxicity Syndromes; Oxazolidinones; Rats, Inbred LEC; Tetrazoles; Toxicity Tests, Chronic | 2015 |
Molecular characterization of linezolid-resistant CoNS isolates in Japan.
Topics: Acetamides; Alleles; Anti-Bacterial Agents; Bacterial Proteins; Coagulase; DNA, Bacterial; DNA, Ribosomal; Genotype; Humans; Japan; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcus | 2015 |
Linezolid in the treatment of disseminated nontuberculous mycobacterial infection in anti-interferon-gamma autoantibody-positive patients.
Topics: Acetamides; Adolescent; Adult; Anti-Bacterial Agents; Autoantibodies; Drug Administration Schedule; Female; Hospitals, University; Humans; Interferon-gamma; Linezolid; Male; Middle Aged; Mycobacterium Infections, Nontuberculous; Oxazolidinones; Retrospective Studies; Thailand | 2014 |
Mechanisms of linezolid resistance in staphylococci and enterococci isolated from two teaching hospitals in Shanghai, China.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Cell Wall; China; Drug Resistance, Bacterial; Enterococcus; Gene Transfer, Horizontal; Gram-Positive Bacterial Infections; Hospitals, Teaching; Humans; Linezolid; Microbial Sensitivity Tests; Microscopy, Electron, Transmission; Oxazolidinones; Point Mutation; Ribosomal Proteins; RNA, Ribosomal, 23S; Staphylococcus | 2014 |
Continuous administration of linezolid in pneumonia: what is the level of proof?
Topics: Acetamides; Anti-Infective Agents; Comorbidity; Critical Illness; Humans; Infusions, Intravenous; Intensive Care Units; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Pneumonia | 2015 |
Mode of encapsulation of linezolid by β-cyclodextrin and its role in bovine serum albumin binding.
Topics: Acetamides; Anti-Infective Agents; beta-Cyclodextrins; Linezolid; Molecular Docking Simulation; Oxazolidinones; Protein Synthesis Inhibitors; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2015 |
In vitro resistance studies with bacteria that exhibit low mutation frequencies: prediction of "antimutant" linezolid concentrations using a mixed inoculum containing both susceptible and resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mutation Rate; Oxazolidinones; Staphylococcus aureus | 2015 |
Concentration-response studies and modelling of the pharmacodynamics of linezolid: Staphylococcus aureus versus Enterococcus faecium.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus faecium; Linezolid; Microbial Viability; Models, Theoretical; Oxazolidinones; Staphylococcus aureus; Time Factors | 2015 |
New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles.
Topics: Acetamides; Anti-Bacterial Agents; Binding Sites; Cell Survival; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacteria; Hep G2 Cells; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Conformation; Molecular Docking Simulation; Nucleic Acid Conformation; Oxadiazoles; Oxazolidinones; RNA, Ribosomal, 23S; Staphylococcus aureus; Stereoisomerism | 2014 |
PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis.
Topics: Acetamides; Algorithms; Animals; Anti-Bacterial Agents; Extensively Drug-Resistant Tuberculosis; Fluorodeoxyglucose F18; Humans; Linezolid; Lymph Nodes; Macaca; Multimodal Imaging; Oxazolidinones; Positron-Emission Tomography; Stem Cells; Tomography, X-Ray Computed; Treatment Outcome | 2014 |
In vitro susceptibility to methicillin, vancomycin and linezolid of staphylococci isolated from bloodstream infections in eastern Turkey.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Humans; Linezolid; Methicillin; Microbial Sensitivity Tests; Oxazolidinones; Sepsis; Staphylococcal Infections; Staphylococcus aureus; Turkey; Vancomycin | 2014 |
Results of the surveillance of Tedizolid activity and resistance program: in vitro susceptibility of gram-positive pathogens collected in 2011 and 2012 from the United States and Europe.
Topics: Acetamides; Anti-Bacterial Agents; Epidemiological Monitoring; Europe; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Organophosphates; Oxazoles; Oxazolidinones; Ribosomal Proteins; RNA, Ribosomal, 23S; United States | 2015 |
Management of a young female patient with Fournier's gangrene and Lemierre's syndrome.
Topics: Acetamides; Anti-Bacterial Agents; Antifungal Agents; Candida albicans; Candidiasis; Caspofungin; Debridement; Drug Therapy, Combination; Echinocandins; Female; Fournier Gangrene; Humans; Klebsiella Infections; Klebsiella pneumoniae; Lemierre Syndrome; Linezolid; Lipopeptides; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Young Adult | 2014 |
Linezolid bladder irrigation as adjunctive treatment for a vancomycin-resistant Enterococcus faecium catheter-associated urinary tract infection.
Topics: Acetamides; Aged, 80 and over; Anti-Bacterial Agents; Cross Infection; Enterococcus faecium; Fatal Outcome; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Therapeutic Irrigation; Urinary Bladder; Urinary Tract Infections; Vancomycin Resistance | 2015 |
Severe linezolid-induced lactic acidosis in a cirrhosis patient.
Topics: Acetamides; Acidosis, Lactic; Adult; Anti-Infective Agents; Female; Humans; Linezolid; Liver Cirrhosis; Oxazolidinones; Severity of Illness Index | 2015 |
Investigation of linezolid resistance in Staphylococcus epidermidis: first reported linezolid resistant coagulase negative staphylococcus in Turkey.
Topics: Acetamides; Anti-Infective Agents; Coagulase; Disk Diffusion Antimicrobial Tests; Drug Resistance, Microbial; Female; Gene Amplification; Humans; Linezolid; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Turkey | 2014 |
Biofilm inhibition of linezolid-like Schiff bases: synthesis, biological activity, molecular docking and in silico ADME prediction.
Topics: Acetamides; Anti-Infective Agents; Biofilms; Computer Simulation; Linezolid; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Molecular Docking Simulation; Oxazolidinones; Schiff Bases | 2015 |
Linezolid-resistant staphylococcal bacteraemia: A multicentre case-case-control study in Italy.
Topics: Acetamides; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Case-Control Studies; Catheter-Related Infections; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Female; Humans; Italy; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Typing; Oxazolidinones; Point Mutation; Retrospective Studies; Risk Factors; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcus; Survival Analysis; Young Adult | 2015 |
Linezolid is a novel and effective treatment for septic pulmonary embolism.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Bacteremia; Female; Humans; Linezolid; Oxazolidinones; Pulmonary Embolism; Staphylococcal Infections | 2015 |
Linezolid has unique immunomodulatory effects in post-influenza community acquired MRSA pneumonia.
Topics: Acetamides; Animals; Humans; Immunomodulation; Influenza A Virus, H1N1 Subtype; Influenza, Human; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Oxazolidinones; Pneumonia, Bacterial; Staphylococcal Infections | 2015 |
In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis from Shenyang, north of China.
Topics: Acetamides; Anti-Bacterial Agents; China; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2015 |
[Evaluation of second-line antituberculosis drug susceptibilities of multidrug-resistant Mycobacterium tuberculosis complex isolates by E-test method].
Topics: Acetamides; Antitubercular Agents; Culture Media; Drug Resistance, Multiple, Bacterial; Ethionamide; Humans; Kanamycin; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Ofloxacin; Oxazolidinones; Reagent Strips; Sensitivity and Specificity; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2015 |
Visual hallucinations: a treatment-emergent adverse effect of linezolid.
Topics: Acetamides; Hallucinations; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Protein Synthesis Inhibitors | 2015 |
Linezolid, vancomycin and daptomycin modulate cytokine production, Toll-like receptors and phagocytosis in a human in vitro model of sepsis.
Topics: Acetamides; Anti-Bacterial Agents; Cell Line; Cytokines; Daptomycin; Escherichia coli; Gene Expression Profiling; Gram-Positive Bacteria; Humans; Immunologic Factors; Linezolid; Models, Theoretical; Monocytes; Oxazolidinones; Phagocytosis; Sepsis; Toll-Like Receptors; Vancomycin | 2015 |
Minimal inhibitory concentration drift of glycopeptides and linezolid against S. Aureus at a Chinese children's center, 2009-2013.
Topics: Acetamides; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; China; Drug Resistance, Bacterial; Female; Hospitals, Pediatric; Humans; Infant; Infant, Newborn; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Vancomycin | 2015 |
Treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose.
Topics: Acetamides; Aged; Cardiac Surgical Procedures; Humans; Linezolid; Male; Mediastinitis; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Postoperative Complications; Renal Insufficiency; Staphylococcal Infections; Thrombocytopenia | 2015 |
Thinking outside the "bug": a unique assay to measure intracellular drug penetration in gram-negative bacteria.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Chromatography, High Pressure Liquid; Escherichia coli; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Linezolid; Mass Spectrometry; Oxazolidinones; Permeability; Pseudomonas aeruginosa | 2015 |
Potential drug interaction between warfarin and linezolid.
Topics: Acetamides; Aged; Anti-Infective Agents; Anticoagulants; Drug Synergism; Female; Humans; International Normalized Ratio; Linezolid; Male; Middle Aged; Oxazolidinones; Prothrombin Time; Retrospective Studies; Time Factors; Warfarin | 2015 |
Comparative Efficacy of Ceftaroline with Linezolid against Staphylococcus aureus and Methicillin Resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2015 |
[Efficiency and safety of linezol in the treatment of neonatal sepsis].
Topics: Acetamides; Anti-Infective Agents; Female; Humans; Infant, Newborn; Linezolid; Male; Oxazolidinones; Sepsis | 2015 |
Successful treatment of multifoci nocardial brain abscesses: a case report and literature review.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Brain Abscess; Cefoperazone; Drug Therapy, Combination; Humans; Immunocompromised Host; Linezolid; Male; Nocardia Infections; Opportunistic Infections; Oxazolidinones; Sulbactam; Trimethoprim, Sulfamethoxazole Drug Combination | 2015 |
Report-Isolation identification and control of vancomycin resistant Staphylococcus aureus.
Topics: Acetamides; Anti-Bacterial Agents; Cinnamomum zeylanicum; Clindamycin; Curcuma; Fluoroquinolones; Garlic; Humans; Linezolid; Mentha; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Moxifloxacin; Nigella sativa; Oxazolidinones; Pakistan; Plant Extracts; Staphylococcal Infections; Staphylococcus aureus; Surgical Wound Infection; Syzygium; Vancomycin Resistance; Wound Infection | 2015 |
Linezolid for XDR-TB--Final Study Outcomes.
Topics: Acetamides; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Mycobacterium tuberculosis; Oxazolidinones; Protein Synthesis Inhibitors; Sputum; Treatment Outcome | 2015 |
Complex long-distance effects of mutations that confer linezolid resistance in the large ribosomal subunit.
Topics: Anti-Bacterial Agents; Binding Sites; Drug Resistance, Bacterial; Linezolid; Molecular Dynamics Simulation; Mutation; Nucleotides; Oxazolidinones; Protein Synthesis Inhibitors; Ribosome Subunits, Large, Archaeal | 2015 |
Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies.
Topics: Acetamides; Animals; Anti-Infective Agents; Bacteria; Biological Availability; Drug Design; Ether-A-Go-Go Potassium Channels; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Models, Molecular; Oxazoles; Oxazolidinones; Potassium Channel Blockers; Staphylococcal Infections; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles | 2015 |
TB: the tap's down a notch – but the water's polluted.
Topics: Acetamides; Compassionate Use Trials; Congresses as Topic; Diarylquinolines; Drug Resistance, Multiple; Guidelines as Topic; Humans; Linezolid; Mycobacterium tuberculosis; Oxazolidinones; South Africa; Tuberculosis; Tuberculosis Vaccines; Tuberculosis, Multidrug-Resistant; Ventilation | 2014 |
Optimum initial loading dose of vancomycin for pneumonia caused by methicillin-resistant Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Methicillin; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Staphylococcus aureus; Vancomycin | 2016 |
Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis.
Topics: Animals; Antitubercular Agents; Bacterial Load; Diarylquinolines; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Synergism; Female; Linezolid; Lung; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Nitroimidazoles; Organophosphates; Oxazoles; Oxazolidinones; Pyrazinamide; Time Factors; Treatment Outcome; Tuberculosis, Pulmonary | 2016 |
Asymptomatic group B streptococcal bacteriuria among pregnant women in Saudi Arabia.
Topics: Acetamides; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Asymptomatic Diseases; Bacteriuria; Cystitis; Female; Humans; Linezolid; Microbial Sensitivity Tests; Middle Aged; Oxazolidinones; Pregnancy; Pregnancy Complications, Infectious; Prevalence; Pyelonephritis; Pyuria; Saudi Arabia; Streptococcal Infections; Streptococcus agalactiae | 2015 |
Simultaneous determination of tedizolid and linezolid in rat plasma by ultra performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.
Topics: Animals; Chromatography, High Pressure Liquid; Limit of Detection; Linear Models; Linezolid; Male; Oxazolidinones; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Tetrazoles | 2016 |
Linezolid for multidrug-resistant tuberculosis: How should we approach it?
Topics: Acetamides; Antitubercular Agents; Humans; Linezolid; Mycobacterium tuberculosis; Oxazolidinones; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2016 |
Linezolid for Treating Tuberculosis: A Delicate Balancing Act.
Topics: Acetamides; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Mycobacterium tuberculosis; Oxazolidinones; Treatment Outcome; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2015 |
Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Linezolid; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Oxazolidinones; Ribosomal Protein L3; Ribosomal Proteins | 2016 |
Efficacy, safety and tolerability of linezolid for the treatment of XDR-TB: a study in China.
Topics: Antitubercular Agents; China; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Oxazolidinones; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2016 |
Activity of linezolid and tedizolid against clinical isolates of methicillin-resistant and methicillin and linezolid resistant Staphylococcus aureus: an in vitro comparison.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Bacterial; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Tetrazoles | 2016 |
Tedizolid and Linezolid for Treatment of Acute Bacterial Skin and Skin Structure Infections of the Lower Extremity versus Non-Lower-Extremity Infections
Topics: Adult; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Randomized Controlled Trials as Topic; Skin Diseases, Bacterial; Tetrazoles; Treatment Outcome | 2017 |
[Clinical efficacy and safety of vancomycin compared with linezolid for the treatment of neonatal gram-positive bacterial sepsis].
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Chi-Square Distribution; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Incidence; Infant, Newborn; Linezolid; Male; Middle Aged; Neonatal Sepsis; Oxazolidinones; Platelet Count; Retrospective Studies; Thrombocytopenia; Treatment Outcome; Vancomycin | 2016 |
Comparative activity of tedizolid against clinical isolates of linezolid-resistant coagulase-negative staphylococci and methicillin-resistant Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Coagulase; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Tetrazoles | 2017 |
A validated UPLC-MS/MS method for the analysis of linezolid and a novel oxazolidinone derivative (PH027) in plasma and its application to tissue distribution study in rabbits.
Topics: Animals; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Limit of Detection; Linezolid; Oxazolidinones; Rabbits; Tandem Mass Spectrometry; Tissue Distribution; Triazoles | 2017 |
Topics: Aminoglycosides; Anti-Bacterial Agents; Clostridioides difficile; Drug Resistance, Multiple, Bacterial; Enterocolitis, Pseudomembranous; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Oxazolidinones; Polymerase Chain Reaction; Pyrrolidines; Quinolones; Ribotyping | 2017 |
Prolonged use of tedizolid in a pulmonary non-tuberculous mycobacterial infection after linezolid-induced toxicity.
Topics: Aged; Anti-Bacterial Agents; Drug Tolerance; Humans; Linezolid; Lung; Male; Mycobacterium avium-intracellulare Infection; Mycobacterium Infections, Nontuberculous; Mycobacterium kansasii; Nontuberculous Mycobacteria; Oxazolidinones; Tetrazoles; Time Factors | 2017 |
Exploring the pharmacodynamic interactions between tedizolid and other orally bioavailable antimicrobials against Staphylococcus aureus and Staphylococcus epidermidis.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Drug Interactions; Fluoroquinolones; Humans; Kinetics; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Oxazolidinones; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Tetrazoles; Trimethoprim, Sulfamethoxazole Drug Combination | 2017 |
Detection of novel oxazolidinone and phenicol resistance gene optrA in enterococcal isolates from food animals and animal carcasses.
Topics: Animals; Anti-Bacterial Agents; Bacterial Typing Techniques; Cattle; Chickens; Chloramphenicol; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus; Enterococcus faecalis; Feces; Food Microbiology; Gram-Positive Bacterial Infections; Linezolid; Multilocus Sequence Typing; Mutation; Oxazolidinones; Republic of Korea; Swine; Thiamphenicol | 2017 |
Linezolid for Children With Tuberculous Meningitis: More Evidence Required.
Topics: Child; Humans; Linezolid; Oxazolidinones; Tuberculosis, Meningeal | 2017 |
Re: "Linezolid for Children With Tuberculous Meningitis: More Evidence Required".
Topics: Child; Humans; Linezolid; Oxazolidinones; Tuberculosis, Meningeal | 2017 |
Examination of bedaquiline- and linezolid-resistant Mycobacterium tuberculosis isolates from the Moscow region.
Topics: Acetamides; Antitubercular Agents; Diarylquinolines; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Moscow; Mutation; Mycobacterium tuberculosis; Oxazolidinones; Prospective Studies; Ribosomal Protein L3; Tuberculosis, Multidrug-Resistant | 2017 |
Linezolid versus vancomycin in Methicillin Resistant Staphylococcus aureus nosocomial pneumonia in the elderly.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Cross Infection; Humans; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pneumonia, Staphylococcal; Vancomycin | 2017 |
Activity of LCB01-0371, a Novel Oxazolidinone, against Mycobacterium abscessus.
Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Linezolid; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Oxazolidinones | 2017 |
Linezolid activity against clinical Gram-positive cocci with advanced antimicrobial drug resistance in Iran.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Positive Cocci; Humans; Iran; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Streptococcus pneumoniae; Vancomycin-Resistant Enterococci | 2017 |
Topics: Antitubercular Agents; Base Sequence; Binding Sites; Chloramphenicol; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Protein Synthesis Inhibitors; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Sequence Analysis, DNA; Tuberculosis, Pulmonary | 2017 |
An Update on the Structure of Oxazolidinone Analogs and a Comparison with Linezolid in Terms of In Vitro and Intracellular Efficacy against Clinically Relevant Bacterial Species.
Topics: Anti-Bacterial Agents; Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Structure-Activity Relationship | 2017 |
Thrombocytopenia with Tedizolid and Linezolid.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Oxazolidinones; Tetrazoles; Thrombocytopenia | 2018 |
In vitro activity of tedizolid against the Mycobacterium abscessus complex.
Topics: Amikacin; Anti-Bacterial Agents; Ciprofloxacin; Clarithromycin; Drug Combinations; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Minocycline; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Oxazolidinones; Tetrazoles; Tigecycline | 2018 |
Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes.
Topics: Electron Transport Chain Complex Proteins; HL-60 Cells; Humans; Linezolid; Microbial Sensitivity Tests; Mitochondria; Mitochondrial Proteins; Oxazolidinones; Staphylococcus aureus; Tetrazoles; THP-1 Cells | 2018 |
Determination of Tedizolid susceptibility interpretive criteria for gram-positive pathogens according to clinical and laboratory standards institute guidelines.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Linezolid; Mice; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Streptococcus agalactiae; Streptococcus pyogenes; Tetrazoles | 2018 |
Topics: Animals; Anti-Bacterial Agents; Azithromycin; Bridged Bicyclo Compounds, Heterocyclic; Clarithromycin; Diterpenes; Humans; Josamycin; Linezolid; Macrolides; Oomycetes; Oxazolidinones; Phosphorylcholine; Pleuromutilins; Polycyclic Compounds; Pythiosis; Pythium | 2018 |
Whole transcriptome analysis reveals potential novel mechanisms of low-level linezolid resistance in Enterococcus faecalis.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Gene Expression Profiling; Linezolid; Oxazolidinones; Transcriptome; Up-Regulation | 2018 |
Dissemination of Staphylococcus epidermidis ST22 With Stable, High-Level Resistance to Linezolid and Tedizolid in the Greek-Turkish Region (2008-2016).
Topics: Aged; Anti-Bacterial Agents; Cross Infection; Drug Resistance, Bacterial; Fatal Outcome; Genes, Bacterial; Humans; Linezolid; Male; Multiple Organ Failure; Mutation; Oxazolidinones; Staphylococcal Infections; Staphylococcus epidermidis; Tetrazoles; Turkey | 2018 |
An in vitro evaluation of the efficacy of tedizolid: implications for the treatment of skin and soft tissue infections.
Topics: Anti-Bacterial Agents; Biofilms; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Soft Tissue Infections; Staphylococcal Skin Infections; Staphylococcus; Tetrazoles | 2018 |
In vitro activity of tedizolid and comparator agents against clinical Gram-positive isolates recovered from patients with cancer.
Topics: Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Microbial Viability; Oxazolidinones; Tetrazoles; Vancomycin | 2018 |
Pharmacokinetics, Pharmacodynamics, and Tolerability of Single-Dose Oral LCB01-0371, a Novel Oxazolidinone with Broad-Spectrum Activity, in Healthy Volunteers.
Topics: Adult; Anti-Bacterial Agents; Gram-Positive Bacteria; Healthy Volunteers; Humans; Linezolid; Male; Microbial Sensitivity Tests; Oxazolidinones; Young Adult | 2018 |
Daptomycin and vancomycin heteroresistance revealed among CC5-SCCmecII MRSA clone and in vitro evaluation of treatment alternatives.
Topics: Bacterial Proteins; Bacteriolysis; Brazil; Cell Wall; Daptomycin; Drug Resistance, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Multilocus Sequence Typing; Oxazolidinones; Polymorphism, Single Nucleotide; Staphylococcal Infections; Tetrazoles; Vancomycin | 2018 |
The Sterilizing Effect of Intermittent Tedizolid for Pulmonary Tuberculosis.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Microbial Sensitivity Tests; Monte Carlo Method; Mycobacterium tuberculosis; Oxazolidinones; Tetrazoles; Tuberculosis, Pulmonary | 2018 |
Evaluation of the ability of linezolid and tedizolid to eradicate intraosteoblastic and biofilm-embedded Staphylococcus aureus in the bone and joint infection setting.
Topics: Anti-Bacterial Agents; Biofilms; Granulocyte Precursor Cells; Humans; Linezolid; Microbial Sensitivity Tests; Models, Theoretical; Osteoarthritis; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Tetrazoles | 2019 |
Subinhibitory concentrations of tedizolid potently inhibit extracellular toxin production by methicillin-sensitive and methicillin-resistant Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Bacterial Toxins; Dose-Response Relationship, Drug; Enterotoxins; Erythrocytes; Exotoxins; Hemolysin Proteins; Humans; Leukocidins; Linezolid; Methicillin; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Nafcillin; Oxazolidinones; Rabbits; Sheep; Staphylococcus aureus; Superantigens; Tetrazoles | 2019 |
Oxazolidinones Can Replace Clarithromycin in Combination with Rifampin in a Mouse Model of Buruli Ulcer.
Topics: Animals; Anti-Bacterial Agents; Buruli Ulcer; Clarithromycin; Disease Models, Animal; Female; Linezolid; Mice; Mice, Inbred BALB C; Mycobacterium ulcerans; Oxazolidinones; Rifampin; Tetrazoles | 2019 |
Comparative efficacy of human-simulated epithelial lining fluid exposures of tedizolid, linezolid and vancomycin in neutropenic and immunocompetent murine models of staphylococcal pneumonia.
Topics: Animals; Anti-Bacterial Agents; Colony Count, Microbial; Disease Models, Animal; Female; Linezolid; Lung; Mice, Inbred BALB C; Neutropenia; Oxazolidinones; Pneumonia, Staphylococcal; Protein Synthesis Inhibitors; Tetrazoles; Treatment Outcome; Vancomycin | 2019 |
Myelosuppression with Oxazolidinones: Are There Differences?
Topics: Humans; Linezolid; Oxazolidinones; Thrombocytopenia | 2019 |
Reply to Hardalo et al., "Myelosuppression with Oxazolidinones: Are There Differences?"
Topics: Humans; Linezolid; Oxazolidinones; Thrombocytopenia | 2019 |
Detection of oxazolidinone and phenicol resistant enterococcal isolates from duck feces and carcasses.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Proteins; Chloramphenicol; Ciprofloxacin; Drug Resistance, Multiple, Bacterial; Ducks; Enterococcus faecalis; Enterococcus faecium; Erythromycin; Feces; Genes, Bacterial; Linezolid; Microbial Sensitivity Tests; Multilocus Sequence Typing; Oxazolidinones; Republic of Korea; Ribosomal Protein L3; RNA, Ribosomal, 23S; Tetracycline; Thiamphenicol | 2019 |
Efficacy of Tedizolid against Enterococci and Staphylococci, Including
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Daptomycin; Disease Models, Animal; Enterococcus faecalis; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxazolidinones; Peritonitis; Staphylococcus; Tetrazoles | 2019 |
tedizolid (SIVEXTRO*) in skin and soft-tissue infections.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Soft Tissue Infections; Staphylococcal Infections; Tetrazoles | 2017 |
Enantioselective recognition of sutezolid by cyclodextrin modified non-aqueous capillary electrophoresis and explanation of complex formation by means of infrared spectroscopy, NMR and molecular modelling.
Topics: beta-Cyclodextrins; Cyclodextrins; Electrophoresis, Capillary; Linezolid; Magnetic Resonance Spectroscopy; Models, Molecular; Oxazolidinones; Spectrophotometry, Infrared; Stereoisomerism; Tetrazoles | 2019 |
Comparison of the microbiological efficacy of tedizolid and linezolid in acute bacterial skin and skin structure infections: pooled data from phase 3 clinical trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Child; Clinical Trials, Phase III as Topic; Double-Blind Method; Female; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Randomized Controlled Trials as Topic; Skin Diseases, Bacterial; Soft Tissue Infections; Tetrazoles; Treatment Outcome; Young Adult | 2019 |
Comparative
Topics: Anti-Bacterial Agents; Asian People; Gram-Positive Bacterial Infections; Humans; In Vitro Techniques; Inpatients; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Tetrazoles | 2019 |
Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines.
Topics: Cell Line; Electron Transport Complex IV; Humans; Linezolid; Megakaryocyte Progenitor Cells; Mitochondria; Oxazolidinones; Oxygen Consumption; Protein Synthesis Inhibitors; Tetrazoles; Thrombocytopenia | 2019 |
Solar-mediated degradation of linezolid and tedizolid under simulated environmental conditions: Kinetics, transformation and toxicity.
Topics: Aliivibrio fischeri; Anti-Bacterial Agents; Bacillus subtilis; Environmental Restoration and Remediation; Kinetics; Linezolid; Molecular Structure; Oxazolidinones; Photolysis; Sunlight; Tetrazoles; Water Pollutants, Chemical | 2020 |
In vitro evaluation of the antibacterial activities of radezolid and linezolid for Streptococcus agalactiae.
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Typing; Oxazolidinones; RNA, Ribosomal, 23S; Streptococcal Infections; Streptococcus agalactiae | 2020 |
Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria.
Topics: Antitubercular Agents; Bacteria, Anaerobic; Drug Resistance, Multiple, Bacterial; Drug Synergism; Humans; Linezolid; Mycobacterium tuberculosis; Nitroimidazoles; Oxazolidinones; Tuberculosis, Multidrug-Resistant | 2020 |
The first case of teeth discoloration induced by linezolid in children in China Mainland.
Topics: Acetamides; Anti-Bacterial Agents; Child; China; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones | 2020 |
Mycobacterium abscessus Associated Peritonitis with CAPD Successfully Treated Using a Linezolid and Tedizolid Containing Regimen Suggested Immunomodulatory Effects.
Topics: Adult; Anti-Bacterial Agents; Chronic Disease; Female; Glomerulonephritis; Humans; Immunocompromised Host; Linezolid; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Oxazolidinones; Peritoneal Dialysis, Continuous Ambulatory; Peritonitis; Tetrazoles | 2020 |
Detection of the enterococcal oxazolidinone/phenicol resistance gene optrA in Campylobacter coli.
Topics: Animals; Anti-Bacterial Agents; Campylobacter coli; Chickens; China; Chloramphenicol; Drug Resistance, Multiple, Bacterial; Ducks; Enterococcus; Genes, Bacterial; Genomic Islands; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Plasmids; Thiamphenicol | 2020 |
The epidemiology and molecular characteristics of linezolid-resistant
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Biofilms; China; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Female; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Oxazolidinones; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus capitis; Whole Genome Sequencing; Young Adult | 2020 |
Successful Treatment of Diabetic Foot Osteomyelitis with Dalbavancin.
Topics: Anti-Bacterial Agents; Burns; Daptomycin; Diabetes Mellitus, Type 2; Diabetic Foot; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Middle Aged; Osteomyelitis; Oxazolidinones; Teicoplanin; Tetrazoles; Tigecycline | 2020 |
Tedizolid: a service evaluation in a large UK teaching hospital.
Topics: Anti-Bacterial Agents; Bone Diseases, Infectious; Female; Hospitals, Teaching; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Retrospective Studies; Tetrazoles; Treatment Outcome; United Kingdom | 2021 |
High-throughput and wide-range simultaneous determination of linezolid, daptomycin and tedizolid in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Daptomycin; Humans; Linezolid; Oxazolidinones; Reproducibility of Results; Tandem Mass Spectrometry; Tetrazoles | 2021 |
Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit using UHPLC-MS/MS method.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Azoles; Carbapenems; Chromatography, High Pressure Liquid; Ciprofloxacin; Daptomycin; Doripenem; Drug Monitoring; Female; Fluconazole; Fluoroquinolones; Humans; Intensive Care Units; Levofloxacin; Linezolid; Male; Meropenem; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Oxazines; Oxazolidinones; Quinolones; Tandem Mass Spectrometry; Tetrazoles; Voriconazole | 2021 |
Antimicrobial susceptibility of bacteremic vancomycin-resistant Enterococcus faecium to eravacycline, omadacycline, lipoglycopeptides, and other comparator antibiotics: Results from the 2019-2020 Nationwide Surveillance of Multicenter Antimicrobial Resist
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteremia; Daptomycin; Drug Resistance, Bacterial; Enterococcus faecium; Epidemiological Monitoring; Gram-Positive Bacterial Infections; Humans; Linezolid; Lipoglycopeptides; Microbial Sensitivity Tests; Oxazolidinones; Taiwan; Tetracyclines; Tetrazoles; Tigecycline; Vancomycin; Vancomycin-Resistant Enterococci; Virginiamycin | 2021 |
Efficacy and safety of tedizolid in a patient with linezolid-induced neutropenia: A case report.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Microbial Sensitivity Tests; Neutropenia; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; Tetrazoles | 2021 |
Hematological side effect analysis of linezolid in MDR-TB patients with individual therapy.
Topics: Acetamides; Anemia; Antitubercular Agents; Drug-Related Side Effects and Adverse Reactions; Humans; Linezolid; Oxazolidinones; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2021 |
Comparison of the in vitro activity of linezolid, tedizolid, sutezolid, and delpazolid against rapidly growing mycobacteria isolated in Beijing, China.
Topics: Anti-Bacterial Agents; Beijing; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium abscessus; Oxazolidinones; Tetrazoles | 2021 |
Serious adverse events with tedizolid and linezolid: pharmacovigilance insights through the FDA adverse event reporting system.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Female; Humans; Linezolid; Male; Middle Aged; Oxazolidinones; Pharmacovigilance; Product Surveillance, Postmarketing; Tetrazoles; United States; United States Food and Drug Administration | 2021 |
Different intra-cerebrospinal distribution of linezolid in patients with inflammatory meningitis.
Topics: Acetamides; Anti-Bacterial Agents; Cerebrospinal Fluid; Humans; Linezolid; Meningitis, Bacterial; Oxazolidinones | 2021 |
Topics: Animals; Antitubercular Agents; Linezolid; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones | 2021 |
Exploratory Cost-Effectiveness Analysis for Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infections: Is Linezolid or Daptomycin Favored Over Vancomycin?
Topics: Acetamides; Anti-Bacterial Agents; Cost-Benefit Analysis; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Sepsis; Staphylococcal Infections; Vancomycin | 2021 |
Therapeutic drug monitoring of linezolid: HPLC-based assays for routine quantification of linezolid in human serum and cerebrospinal fluid.
Topics: Acetamides; Acetonitriles; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Linezolid; Oxazolidinones; Water | 2023 |
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.
Topics: Alanine; Anti-Bacterial Agents; Binding Sites; Cryoelectron Microscopy; Linezolid; Models, Molecular; Oxazolidinones; Peptidyl Transferases; Protein Biosynthesis; Ribosomes; RNA, Ribosomal; RNA, Transfer | 2022 |
Putting the antibiotics chloramphenicol and linezolid into context.
Topics: Anti-Bacterial Agents; Bacteria; Chloramphenicol; Drug Development; Drug Resistance, Bacterial; Humans; Linezolid; Models, Molecular; Oxazolidinones; Protein Biosynthesis; Protein Synthesis Inhibitors; Ribosomes; Structure-Activity Relationship | 2022 |
Development of a Method of Liquid Chromatography Coupled with Tandem Mass Spectrometry for Simultaneous Determination of Linezolid and Tedizolid in Human Plasma.
Topics: Chromatography, Liquid; Humans; Linezolid; Oxazolidinones; Reproducibility of Results; Tandem Mass Spectrometry; Tetrazoles | 2022 |
Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Topics: Anti-Bacterial Agents; Cryoelectron Microscopy; Drug Resistance, Bacterial; Enterococcus faecalis; Linezolid; Oxazolidinones; RNA, Transfer | 2022 |
Prospects of contezolid (MRX-I) against multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis.
Topics: Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Pyridones; Tuberculosis, Multidrug-Resistant | 2022 |
Long-term use of tedizolid for pulmonary nocardiosis.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Nocardia; Nocardia Infections; Oxazolidinones; Tetrazoles | 2022 |
Enantioseparation of linezolid and tedizolid using validated high-performance liquid chromatographic method.
Topics: Chromatography, High Pressure Liquid; Linezolid; Oxazolidinones; Stereoisomerism; Tetrazoles | 2022 |
In vitro activity of tedizolid and linezolid against multidrug-resistant Mycobacterium tuberculosis: a comparative study using microdilution broth assay and genomics.
Topics: Anti-Bacterial Agents; Genomics; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Tetrazoles; Tuberculosis, Multidrug-Resistant | 2022 |
Novel linezolid-based oxazolidinones as potent anticandidiasis and antitubercular agents.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antitubercular Agents; Humans; Linezolid; Microbial Sensitivity Tests; Molecular Docking Simulation; Mycobacterium tuberculosis; Oxazolidinones | 2022 |
WCK 4034: A promising oxazolidinone for treating gram positive infections.
Topics: Animals; Anti-Bacterial Agents; Dogs; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Streptococcus pneumoniae | 2022 |
Activity of Tedizolid and Comparator Agents Against Gram-positive Isolates Causing Skin and Skin Structure Infections in Pediatric Patients in United States Hospitals (2015-2019).
Topics: Adolescent; Adult; Anti-Bacterial Agents; Child; Child, Preschool; Daptomycin; Hospitals; Humans; Infant; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus aureus; Tetrazoles; United States; Vancomycin | 2022 |
Comment on: A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections.
Topics: Adult; Double-Blind Method; Humans; Linezolid; Oxazolidinones; Soft Tissue Infections | 2022 |
Comparing the pharmacokinetics and organ/tissue distribution of anti-methicillin-resistant
Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Daptomycin; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Rats; Sepsis; Tissue Distribution; Vancomycin | 2022 |
Contezolid in complicated skin and soft tissue infection.
Topics: Anti-Bacterial Agents; China; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Pyridones; Soft Tissue Infections; United States | 2022 |
Faecal carriage of enterococci harbouring oxazolidinone resistance genes among healthy humans in the community in Switzerland.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazolidinones; Switzerland | 2022 |
Expert consensus statement on therapeutic drug monitoring and individualization of linezolid.
Topics: Anti-Bacterial Agents; Drug Monitoring; Humans; Linezolid; Oxazolidinones | 2022 |
Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.
Topics: Anti-Bacterial Agents; Erythromycin; Gram-Negative Bacteria; Linezolid; Lipid A; Novobiocin; Oxazolidinones; Rifampin; Vancomycin | 2022 |
The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacteremia; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2022 |
Detection of linezolid resistance cfr gene among MRSA isolates.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2022 |
Drug Degradation Caused by
Topics: Anti-Bacterial Agents; Antitubercular Agents; Flavins; Linezolid; Microbial Sensitivity Tests; Mixed Function Oxygenases; Mutation; Mycobacterium tuberculosis; Oxazolidinones | 2022 |
A Mycobacterium tuberculosis-Infected Patient Who Could Not Tolerate Oral Intake Successfully Treated Using an Intravenous Tedizolid-Containing Regimen.
Topics: Aged; Anti-Bacterial Agents; Antitubercular Agents; Cutaneous Fistula; Ethambutol; Humans; Isoniazid; Levofloxacin; Linezolid; Male; Meropenem; Micafungin; Mycobacterium tuberculosis; Oxazolidinones; Pyrazinamide; Rifampin; Streptomycin; Teicoplanin; Tetrazoles; Tuberculosis | 2022 |
Co-existence of cfr and fosB genes in an MDR Staphylococcus hominis blood isolate from an Italian hospital.
Topics: Hospitals; Italy; Linezolid; Oxazolidinones; Staphylococcus hominis | 2022 |
Spreading of
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Plasmids; Staphylococcal Infections; Swine | 2022 |
optrA-mediated linezolid resistance in an Enterococcus faecalis isolate recovered from a wild raptor (Falco peregrinus peregrinus), central Italy.
Topics: Animals; Anti-Bacterial Agents; Enterococcus faecalis; Linezolid; Oxazolidinones; Raptors | 2023 |
Side-by-Side Profiling of Oxazolidinones to Estimate the Therapeutic Window against Mycobacterial Infections.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Oxazolidinones; Tuberculosis | 2023 |
Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model.
Topics: Animals; Antitubercular Agents; Diarylquinolines; Linezolid; Mice; Nitroimidazoles; Oxazolidinones; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2023 |
Linezolid-Resistant Enterococcus faecalis of Chicken Origin Harbored Chromosome-Borne
Topics: Animals; Anti-Bacterial Agents; Chickens; Chromosomes; Drug Resistance, Bacterial; Enterococcus faecalis; Genes, Bacterial; Gram-Positive Bacterial Infections; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Plasmids | 2023 |
Oral Linezolid Induced Early Onset Hepatic Encephalopathy- A Case Report of 65-year Old Diabetic Female.
Topics: Acetamides; Aged; Anti-Bacterial Agents; Diabetes Mellitus; Female; Hepatic Encephalopathy; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Neurotoxicity Syndromes; Oxazolidinones | 2024 |
Real-world evaluation of linezolid-associated serotonin toxicity with and without concurrent serotonergic agents.
Topics: Acetamides; Adolescent; Adult; Humans; Linezolid; Middle Aged; Oxazolidinones; Retrospective Studies; Serotonin; Serotonin Agents; Serotonin Syndrome | 2023 |
Hyper-thermophilic anaerobic pretreatment enhances the removal of transferable oxazolidinone and phenicol cross-resistance gene optrA in enterococci.
Topics: Anaerobiosis; Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Enterococcus faecalis; Genes, Bacterial; Linezolid; Oxazolidinones | 2023 |
Clinical efficacy of psychiatric nursing-based vancomycin in the treatment of Staphylococcus aureus infectious skin diseases.
Topics: Acetamides; Anti-Bacterial Agents; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Oxazolidinones; Psychiatric Nursing; Retrospective Studies; Skin Diseases, Infectious; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin | 2023 |
Rapid culture-based LNZ test for detection of linezolid susceptibility/resistance in staphylococci and enterococci.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcus; Staphylococcus aureus | 2023 |
Prolonged use of linezolid in bone and joint infections: a retrospective analysis of adverse effects.
Topics: Acetamides; Arthritis, Infectious; Drug-Related Side Effects and Adverse Reactions; Humans; Linezolid; Oxazolidinones; Retrospective Studies | 2023 |