oxazoles has been researched along with tyrosine in 173 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (7.51) | 18.7374 |
| 1990's | 12 (6.94) | 18.2507 |
| 2000's | 59 (34.10) | 29.6817 |
| 2010's | 80 (46.24) | 24.3611 |
| 2020's | 9 (5.20) | 2.80 |
| Authors | Studies |
|---|---|
| Berger, R; Schierbeek, H | 1 |
| Langer, P | 1 |
| Faiman, C; Greslin, JG; Mayberry, WE; Ryan, RJ | 1 |
| Husek, P | 2 |
| Neurath, H; Uren, JR | 1 |
| Pétra, PH | 1 |
| Ellenbogen, L; Stubbs, CS; Taylor, RJ | 2 |
| Cohen, E; Cummings, JR; Gadekar, SM; Johnson, BD; Nibi, S | 1 |
| Lippmann, W; Wishnick, M | 1 |
| Ellenbogen, L; Taylor, RJ | 1 |
| Homandberg, GA; Minor, ST; Peanasky, RJ | 1 |
| Hase, T; Kambayashi, J; Mori, T; Murata, K; Okuyama, M; Sakon, M | 1 |
| Brumell, JH; Grinstein, S | 1 |
| Piña, IC; Rodríguez, AD | 1 |
| Cossins, AR; Weaver, YR | 1 |
| Bajpai, A; Brahmi, Z | 1 |
| Elhanany, E; Hemi, R; Kanety, H; Karasik, A; LeRoith, D; Paz, K; Zick, Y | 1 |
| Lazo, JS; Rice, RL; Settineri, CE; Vogt, A; Wipf, P; Yokokawa, F; Yokokawa, S | 1 |
| Blanchard, SG; Brackeen, MF; Brown, KK; Cobb, JE; Collins, JL; Harrington, WW; Hashim, MA; Henke, BR; Hull-Ryde, EA; Kaldor, I; Kliewer, SA; Lake, DH; Leesnitzer, LM; Lehmann, JM; Lenhard, JM; Miller, JF; Mook, RA; Noble, SA; Oliver, W; Orband-Miller, LA; Parks, DJ; Plunket, KD; Szewczyk, JR; Willson, TM | 1 |
| Blanchard, SG; Boswell, GE; Charifson, PS; Cobb, JE; Collins, JL; Gray-Nunez, Y; Henke, BR; Hull-Ryde, EA; Kazmierski, WM; Lake, DH; Leesnitzer, LM; Lehmann, J; Lenhard, JM; Orband-Miller, LA; Parks, DJ; Plunkett, KD; Tong, WQ | 1 |
| Blanchard, SG; Boswell, EG; Brown, KK; Charifson, PS; Cobb, JE; Collins, JL; Cooper, JP; Dezube, M; Henke, BR; Hull-Ryde, EA; Lake, DH; Lenhard, JM; Oliver, W; Oplinger, J; Parks, DJ; Pentti, M; Plunket, KD; Tong, WQ | 1 |
| Gilmer, T; Risingsong, R; Sporn, MB; Suh, N; Wang, Y; Williams, CR; Willson, TM | 1 |
| Lazo, JS; Rice, RL; Tamura, K; Wipf, P | 1 |
| Gilbert, C; Naccache, PH; Rollet-Labelle, E | 1 |
| Dawson, JF; Holmes, CF; Islam, BF; Luu, HA; McCready, TL; Schmitz, FJ | 1 |
| Vedejs, E; Wang, J | 1 |
| Ryan, CA; Scheer, J; Stratmann, J | 1 |
| Brown, KK; Glass, CK; Li, AC; Palinski, W; Silvestre, MJ; Willson, TM | 1 |
| Chatterjee, VK; Nugent, C; O'Rahilly, S; Prins, JB; Savage, D; Wentworth, JM; Whitehead, JP | 1 |
| Collins, JL; Gampe, RT; Kliewer, SA; Lambert, MH; McKee, DD; Montana, VG; Moore, JT; Moore, LB; Oplinger, JA; Plunket, KD; Willson, TM; Xu, HE | 1 |
| Cobb, JE; Galardi, CM; Kliewer, SA; Lambert, MH; McKee, DD; Montana, VG; Moore, JT; Nolte, RT; Parks, DJ; Plunket, KD; Shearer, BG; Stanley, TB; Stimmel, JB; Willson, TM; Xu, HE | 1 |
| Brosnan, CF; Dumitrescu-Ozimek, L; Feinstein, DL; Galea, E; Gavrilyuk, V; Heneka, MT; Landreth, GE; Pershadsingh, HA; Weinberg, G; Whitacre, CC | 1 |
| Corton, JC; Dohm, GL; Houmard, JA; Kraus, WE; Lang, DB; Li, S; MacLean, PS; Muoio, DM; Way, JM; Winegar, DA | 1 |
| Clemetson, KJ; Navdaev, A | 1 |
| Jensen, BA; Mann, KK; Ryu, HY; Schlezinger, JJ; Sherr, DH | 1 |
| Chen, YE; Fu, M; Lin, Y; Mao, Z; Zhang, J; Zhu, X | 1 |
| Baker, SF; Brown, J; Davis, B; Hong, G; Khatoon, N | 1 |
| Blanchard, SG; Galardi, CM; Holt, JA; Lambert, MH; Leesnitzer, LM; Montana, VG; Moore, LB; Stanley, TB; Stimmel, JB; Xu, HE | 1 |
| Baer, PG; Brown, KK; Chen, L; Clifton, LG; McNulty, JA; Yang, B | 1 |
| DeGrazia, MJ; Heuvel, JP; Peterson, BR; Thompson, J | 1 |
| Baugh, MD; Edwards, DR; Gavrilovic, J; Hogan, A; Hughes, DA; Sampson, MJ; Worley, JR | 1 |
| Chen, YE; Fu, M; Lin, Y; McLntee, FL; Xiao, H; Zhang, J; Zhu, X | 1 |
| Agostini, M; Chatterjee, VK; Garnes, KT; Gurnell, M; Levinson, SH; O'Rahilly, S; Rajanayagam, O; Savage, DB; Schwabe, JW; Smith, AG; Willson, TM; Wood, EM; Xu, HE | 1 |
| Baer, PG; Bennett, T; Brown, KK; Gardiner, SM; Nunez, DJ | 1 |
| Bewley, CA; Fetterolf, B | 1 |
| Bonev, AD; Eckman, DM; Gomez, MF; Heppner, TJ; Nelson, MT; Petkov, GV | 1 |
| Balon, TW; Binz, JG; Brown, KK; Chen, L; Chen, Z; Clifton, LG; Grimes, AM; Harrington, WW; McNulty, JA; Stimpson, SA; Strum, JC; Yang, B | 1 |
| Brown, KK; Carrick, KM; Chen, L; Clifton, LG; McNulty, JA; Pahel, GL; Stimpson, SA; Strum, JC; Winegar, DA; Yang, B | 1 |
| Chen, J; Chen, Q; Jiang, H; Shen, J; Shen, X; Sun, T | 1 |
| Grommes, C; Heneka, MT; Landreth, GE; Schlegel, U | 1 |
| Kaya, T; Sheu, SH; Vajda, S; Waxman, DJ | 1 |
| Adrogue, JV; Brown, KK; Burgmaier, M; Golfman, LS; Guthrie, PH; Sharma, S; Taegtmeyer, H; Van Arsdall, M; Wilson, CR; Young, ME | 1 |
| Bai, R; Dettin, LE; Glazer, RI; Kopelovich, L; Kopleovich, L; Kozikowski, AP; Russell, RG; Wei, ZL; Yin, Y | 1 |
| Abbot, EL; Buchan, KW; Hassall, DG; McCormack, JG; Reynet, C; Yeaman, SJ | 1 |
| Carrick, KM; Clifton, LG; Lin, P; McNulty, JA; Pahel, GL; Stimpson, SA; Strum, JC; Winegar, DA; Yang, B | 1 |
| Haddon, CO; Iravani, MM; Jenner, P; Leung, CC; Rose, S; Sadeghian, M | 1 |
| Dannals, RF; Foss, CA; Henke, BR; Mathews, WB; Pomper, MG; Ravert, HT; Stoermer, D | 1 |
| Bagley, MC; Lach, F; Moody, CJ; Palmer, FN; Pepper, AG; Poriel, C; Slawin, AM | 1 |
| Brown, KK; Carrick, K; Chen, L; Clifton, LG; Geske, R; Han, B; McNulty, JA; Pahel, G; Qian, Y; Stimpson, SA; Strum, J; Triantafillou, JA; Yang, B | 1 |
| Arora, A; Fibuch, EE; Kingston, S; Mao, L; Wang, JQ; Yang, L | 1 |
| Emberley, JK; Schlezinger, JJ; Sherr, DH | 1 |
| Huang, XH; Sun, K; Wang, Q | 2 |
| Cao, YL; Li, S; Liu, HY; Ruan, CM; Wang, LL; Xu, C; Zhou, XB | 1 |
| Chen, L; Chen, W; Diehl, AM; Stimpson, SA; Yang, L; Zhao, C | 1 |
| Bissonnette, SL; Emberley, JK; Schlezinger, JJ; Sherr, DH | 1 |
| Ding, L; Liang, XG; Lou, YJ | 1 |
| Billin, AN; Buckholz, RG; Cobb, JE; Hoekstra, WJ; Iannone, MA; Lambert, MH; Leesnitzer, LM; Nolte, RT; Pearce, KH; Shearer, BG; Trump, RP; Willson, TM; Zhao, SM | 1 |
| Bouancheau, D; Denis, MG; Jarry, A; Laboisse, CL; Masson, D; Mosnier, JF; Mottier, S; Toquet, C | 1 |
| Cheung, CM; Goldberg, FW; Lynch, V; Magnus, P; Russell, CJ; Turnbull, R | 1 |
| Cao, FY; Fang, J; Hong, XP; Liu, R; Pan, XP; Tian, Q; Wang, JZ; Wang, SH | 1 |
| Hong, G; Hughes, A; Lin, X; McCarthy, A; McCarthy, L; Mosteller, M; Sathe, G; Smart, D; Spraggs, C; Traini, C; Van Horn, S; Warren, L | 1 |
| Azukizawa, S; Kanda, M; Kasai, M; Kunishiro, K; Miike, T; Mukai, C; Shirahase, H; Takahashi, K | 1 |
| Aoyama, T; Hayakawa, M; Ito, Y; Iwabuchi, S; Kozakai, S; Kurita, N; Nakagawa, T; Nakajima, T; Yamaguchi, Y | 1 |
| Cwinn, MA; Jones, SP; Kennedy, SW | 1 |
| Cancedda, FD; Cancedda, R; Ulivi, V | 1 |
| Gerstenberger, BS; Konopelski, JP; Lin, J; Stessman, NY | 1 |
| Chapman, V; Kendall, DA; Sagar, DR | 1 |
| de Koning, LJ; Ihling, C; Mechtler, K; Müller, MQ; Rau, O; Schmidt, A; Schubert-Zsilavecz, M; Sinz, A; Syha, Y | 1 |
| Ashton, TT; Baines, D; Bisi, J; Blazer-Yost, BL; Brown, KK; Harrington, W; Kalsi, K; Maurio, FP; Murray, D; Nofziger, C; Smith, CD; West, TA | 1 |
| Chen, XL; Cheng, T; Chu, TG; Gao, WY; Jiang, LF; Li, XY; Li, ZJ; Pan, H; Yang, JQ; Yi, CG; Yu, Q; Zhang, GY; Zheng, MH; Zhou, FY | 1 |
| Castiglia, S; Collino, M; Fantozzi, R; Kapoor, A; Thiemermann, C | 1 |
| Brigandi, R; Chuang, WL; Gardner, S; Goodman, Z; Husa, P; Jonas, M; Levine, R; Makhlouf, H; McHutchison, J; Patel, K; Rockey, D; Rodriguez-Torres, M; Schultz, M; Shiffman, M; Stancil, B; Theodore, D; Watson, H; Webster, A | 1 |
| Arcelay, E; Krapf, D; Pilder, SH; Salicioni, AM; Sanjay, A; Visconti, PE; Wertheimer, EV | 1 |
| Choi, SP; Park, KM; Park, KW; Tontonoz, P; Waki, H | 1 |
| Chen, MS; Hou, N; Liu, SM; Luo, JD; Luo, MS; Sun, P; Xiao, Q; Zhang, GS; Zhang, HN | 1 |
| Bissonnette, SL; Haas, A; Mann, KK; Schlezinger, JJ | 1 |
| Blomeyer, C; Kehl, F; Lange, M; Lazariotto, M; Lotz, C; Pociej, J; Redel, A; Roewer, N; Schmidt, J; Smul, TM; Stumpner, J; Tischer-Zeitz, T | 1 |
| Billheimer, J; Fuki, I; Macphee, C; Millar, JS; Naik, SU; Rader, DJ; Toh, SA; Walker, M | 1 |
| Chartoumpekis, DV; Habeos, IG; Kyriazopoulou, VE; Papavassiliou, AG; Psyrogiannis, AI; Ziros, PG | 1 |
| Aburatani, H; Doi, T; Hamakubo, T; Ishimoto, K; Kawabe, N; Kodama, T; Nakamura, H; Sakai, J; Tachibana, K; Tanaka, T; Yamasaki, D | 1 |
| Berry, EA; Huang, LS | 1 |
| DuBois, RN; Guo, L; Ning, W; Wang, D; Xie, D | 1 |
| Inagaki, K; Makino, H; Matsumoto, Y; Miyoshi, T; Nakamura, E; Otsuka, F; Sada, KE; Takano, M; Takeda, M; Tsukamoto, N | 1 |
| Glazer, RI; Kopelovich, L; Upadhyay, G; Yin, Y; Yuan, H | 1 |
| Müller, MQ; Sinz, A | 1 |
| Biemann, R; Eder, K; Kämmerer, I; Ringseis, R; Wen, G | 1 |
| Alen, F; Gómez, R; Orio, L; Pavón, FJ; Reyes-Cabello, C; Rivera, P; Rodríguez de Fonseca, F; Serrano, A | 1 |
| Fu, Y; Jiang, Z; Li, X; Mo, Z; Tang, C; Xiao, J; Yin, K; Yu, X; Zha, X; Zhao, G | 1 |
| Fernandez-Espejo, E; Flores, JA; Ruiz-Medina, J; Tasset, I; Tunez, I; Valverde, O | 1 |
| Asavapanumas, N; Chatsudthipong, V; Kittayaruksakul, S; Meetam, P; Muanprasat, C; Soodvilai, S | 1 |
| Gochfeld, DJ; Kamel, HN; Olson, JB; Thacker, RW | 1 |
| Kumar, A; Kumar, P; Qiao, Z; Song, ZH | 1 |
| Amu, S; Clifford, E; Downer, EJ; Fallon, PG; Moynagh, PN | 1 |
| Chou, KC; Ma, Y; Wang, RL; Wang, SQ; Xu, WR | 1 |
| Cano, C; Decara, JM; Fresno, N; Macias-González, M; Pavón, FJ; Pérez-Fernández, R; Rivera, P; Rodríguez de Fonseca, F; Romero-Cuevas, M; Serrano, A; Suárez, J; Vida, M | 1 |
| Barreto-Torres, G; Javadov, S; Parodi-Rullán, R | 1 |
| Cai, J; Lin, B; Qu, J; Snider, BJ; Sun, L; Wu, M; Wu, S | 1 |
| Harayama, H; Ishikawa, S; Noda, T; Shidara, O | 1 |
| Alimirah, F; Hawthorne, M; Kalra, A; Kopelovich, L; Mehta, RG; Mehta, RR; Peng, X; Roy, S | 1 |
| Avagliano, C; Calignano, A; Citraro, R; Cosco, D; D'Agostino, G; De Sarro, G; Di Marzo, V; Gatta, L; Guida, F; Maione, S; Petrosino, S; Russo, E; Russo, R; Scicchitano, F; van Luijtelaar, G; van Rijn, CM | 1 |
| Fechner, G; Hooper, JN; Pham, NB; Quinn, RJ; Tran, TD | 1 |
| Ji, M; Li, Y; Lin, Q; Lin, R; Ren, F; Wang, W; Zhang, J | 1 |
| Ihling, CH; Kölbel, K; Müller, MQ; Schwarz, R; Sinz, A; Tänzler, D | 1 |
| Chen, TH; Chiou, YL; Huang, YC; Li, TT; Liu, KC; Liu, LL; Yang, CH | 1 |
| Abu Aboud, O; Weiss, RH; Wettersten, HI | 1 |
| Bai, L; Ji, M; Lin, R; Lu, Y; Qiao, H; Ren, F; Wang, W; Yang, L; Zhang, J | 1 |
| Han, L; Li, MG; Ye, P | 1 |
| Jitonnom, J; Limb, MA; Mulholland, AJ | 1 |
| Baccei, CS; Bravo, Y; Broadhead, A; Bundey, R; Chen, A; Clark, R; Correa, L; Jacintho, JD; Lorrain, DS; Messmer, D; Prasit, P; Stebbins, K; Stock, N | 1 |
| Byun, JH; Hah, YS; Hwang, SC; Joo, HH; Kang, YH; Kim, JW; Park, BW; Rho, GJ; Sung, IY; Woo, DK | 1 |
| Kuwabara, H; Mantoku, D; Marunaka, Y; Matsumura, H; Nakahari, T; Nakano, T; Sawabe, Y; Shimamoto, C; Sugiyama, N; Takahashi, Y; Tanaka, S | 1 |
| Aghaei, HN; Dehpour, AR; Ebrahimi, A; Gholizadeh, R; Gooshe, M; Mousavizadeh, K; Payandemehr, B; Rahimian, R; Varastehmoradi, B | 1 |
| Chen, S; Huang, J; Huang, Q; Liu, B; Liu, P; Luo, J; Pan, X; Zang, L; Zeng, Z; Zhou, S | 1 |
| Capoccia, E; Cipriano, M; De Filippis, D; Esposito, G; Iuvone, T; Negro, L; Sarnelli, G; Scuderi, C; Steardo, L | 1 |
| Abu Aboud, O; Bultman, S; Donohoe, D; Fitch, M; Hellerstein, M; Riiff, T; Weiss, RH | 1 |
| Audano, M; Azcoitia, I; Carozzi, V; Caruso, D; Cavaletti, G; Cermenati, G; Crestani, M; D'Antonio, M; De Fabiani, E; Ferri, C; Garcia-Segura, LM; Giatti, S; Melcangi, RC; Mitro, N; Pettinato, E; Porretta-Serapiglia, C; Saez, E; Scurati, S | 1 |
| Ann, SJ; Chung, JH; Jang, J; Kang, SM; Kim, SH; Lee, SH; Park, BH; Park, S | 1 |
| Kim, J; Lee, H; Park, SD; Roh, JS; Shin, SS; Woo, S; Yoon, M | 1 |
| Baram, SM; Dehpour, AR; Rahimian, R; Rahmatollahi, M; Saeedi Saravi, SS | 1 |
| Denizot, N; Guillot, R; Kouklovsky, C; Vincent, G | 1 |
| Chen, XQ; Lü, J; Wang, MJ; Wu, SH | 1 |
| Jiang, Q; Li, X; Yang, T; Yang, Y; Zhang, H | 1 |
| Dong, JM; Dong, ZX; Hang, PZ; Hou, TT; Li, WM; Li, Y; Liu, GZ; Liu, Y; Liu, YW; Shi, H; Sun, L; Wang, XB; Yuan, Y; Zhan, CC; Zhao, GQ; Zhao, J; Zhao, JJ; Zhou, JH | 1 |
| Agostinucci, K; Colton, HM; Dunn, ME; Engle, SK; Gallacher, M; Gropp, KE; King, NM; Manfredi, TG; More, V; Powe, J; Rodriguez, LA; Serra, D; Shimpi, P; Vetter, FJ | 1 |
| Campos, CR; Cannon, RE; Chan, GN; Evans, RA; Miller, DS; More, VR; Oliver, KD | 1 |
| Hosogi, S; Inui, T; Marunaka, Y; Matsumura, H; Nakahari, T; Sawabe, Y; Shimamoto, C; Tanaka, S | 1 |
| Chang, SH; Jang, BH; Kim, S; Li, DY; Park, KM; Park, KW; Song, NJ; Tontonoz, P; Waki, H; Yun, UJ | 1 |
| Agarwal, AK; Garg, A; Sankella, S | 1 |
| Byrjalsen, I; Christiansen, C; Gardner, S; Goodman, Z; Henriksen, K; Karsdal, MA; Krag, A; Leeming, DJ; Nielsen, MJ; Patel, K; Schuppan, D | 1 |
| Cao, R; Dan, HC; Jiang, W; Ju, L; Qian, G; Wang, G; Wang, X; Wang, Y; Wu, M; Xiao, Y | 1 |
| Kim, J; Lee, H; Lim, J; Shin, SS; Yang, H; Yoon, M; Yoon, S | 1 |
| Campbell, JM; Facchine, KL; Johnson, BS; Joshi, BK; Kraft, ES; Long, S; O'Connell, TM; Paulus, IV; Reynolds, DW; Sides, SL; Wolters, AM | 1 |
| Bagdas, D; Carroll, FI; Damaj, MI; Greenwald, M; Jackson, A; Lichtman, AH; Miles, MF; Muldoon, PP | 1 |
| Ammazzalorso, A; Basile, M; Cama, A; Cataldi, A; Cimini, A; Cristiano, L; De Lellis, L; di Giacomo, V; Di Marcantonio, MC; Florio, R; Mariani-Costantini, R; Mincione, G; Prasad, SC; Sanna, M; Verginelli, F; Verzilli, D | 1 |
| AlSharari, S; Bagdas, D; Donvito, G; Imad Damaj, M; Ivy Carroll, F; Jackson, A; Kulkarni, AR; Lichtman, AH; Meade, JA; Papke, RL; Rahimpour, E; Thakur, GA; Toma, W | 1 |
| Chen, Y; Fillmore, N; Gao, S; Harrington, J; Liu, P; Murphy, E; Springer, D; Stoehr, A; Wang, X; Yang, Y; Zhang, X; Zhu, J | 1 |
| Gu, QY; Jiang, B; Ni, YF; Wang, FY; Wang, H; Wang, JL; Wang, YJ | 1 |
| D'Aniello, E; Damaj, MI; Di Marzo, V; Donvito, G; Giordano, C; Guida, F; Ignatowska-Jankowska, BM; Jackson, A; Lichtman, AH; Maione, S; Mechoulam, R; Muldoon, P; Mustafa, MA; Parker, L; Petrie, GN; Piscitelli, F; Sim-Selley, L; Smoum, R; Vitale, RM | 1 |
| Cordaro, M; Crupi, R; Cuzzocrea, S; D'Amico, R; Di Paola, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Siracusa, R | 1 |
| Babaei, J; Gavzan, H; Hashemi, F; Sayyah, M | 1 |
| Anraku, M; Erickson, L; Eto, N; Kawahara, S; Matsushita, Y; Motoba, I; Nakanishi, T; Sugamoto, K; Suzuki, R; Yamaguchi, Y | 1 |
| Dong, T; Fukunaga, K; Ibata, T; Imachi, H; Iwama, H; Kobayashi, T; Lyu, J; Murao, K; Sato, S; Yonezaki, K; Yoshimoto, T; Zhang, G | 1 |
| Amoroso, R; Arduini, A; Cama, A; Cataldi, A; De Lellis, L; di Giacomo, V; Florio, R; Gallorini, M; Mariani-Costantini, R; Natale, A; Perconti, S; Sanna, M; Verginelli, F; Veschi, S | 1 |
| Jiao, S; Li, Q; Pan, M; Qu, J; Reinach, PS; Srinivasalu, N; Yan, J; Yang, Y; Zhou, X | 1 |
| Ikari, A; Manabe, A; Tabuchi, Y; Takashina, Y | 1 |
| Abbas, MA; Aldaoud, N; Aldossary, SA; Alsalem, M; Altarifi, A; El-Salem, K; Haddad, M; Jaffal, SM; Kalbouneh, H | 1 |
| Du, M; Mao, X; Wang, H | 1 |
| Al Sharif, M; Alov, P; Diukendjieva, A; Pajeva, I; Tsakovska, I; Vitcheva, V | 1 |
| Laghezza, A; Loiodice, F; Piemontese, L; Tortorella, P | 1 |
| Cong, H; Fan, B; Gu, J; Wang, T; Zhong, W | 1 |
| Finn, DP; Gaspar, JC; Llorente-Berzal, A; Okine, BN; Roche, M | 1 |
| Chen, W; Fang, H; Hong, Z; Jin, W; Li, L; Yang, L; Yi, Z; Zhang, G; Zhang, Y | 1 |
| Burdge, GC; Calder, PC; Cooper, C; Lillycrop, KA; Pérez-Mojica, JE | 1 |
| Cao, M; Chen, D; Han, X; Ji, F; Liufu, N; Yao, W; Zeng, Q | 1 |
| Beretta, C; Candura, SM; Cervio, M; Colucci, M; De Angelis, S; Dellabianca, A; Faniglione, M; Tonini, S | 1 |
| Cai, D; Guo, F; Holm, L; Li, Y; Liu, HY; Zhang, K; Zhou, B | 1 |
| Astakhova, AA; Chistyakov, DV; Goriainov, SV; Sergeeva, MG | 1 |
| Du, ZW; Hou, H; Li, JY; Wang, Q; Wei, XC; Wu, XA; Yang, JY; Zhang, W | 1 |
| Cheng, LH; Cui, S; Ge, CL; Guo, YT; Hao, HP; He, QX; Pan, XJ; Wang, GJ; Wang, H; Yan, TT; Zhang, PF; Zhou, JY | 1 |
1 review(s) available for oxazoles and tyrosine
| Article | Year |
|---|---|
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands.
Topics: Acetates; Animals; Benzene Derivatives; Binding Sites; Crystallography, X-Ray; Humans; Indoles; Ligands; Molecular Docking Simulation; Oxazoles; Peroxisome Proliferator-Activated Receptors; Phenylpropionates; Protein Binding; Stereoisomerism; Structure-Activity Relationship; Tyrosine | 2019 |
3 trial(s) available for oxazoles and tyrosine
| Article | Year |
|---|---|
Genetic variants in the epithelial sodium channel associate with oedema in type 2 diabetic patients receiving the peroxisome proliferator-activated receptor gamma agonist farglitazar.
Topics: Adult; Aged; Base Sequence; Diabetes Mellitus, Type 2; DNA Primers; Edema; Epithelial Sodium Channels; Female; Genes, Reporter; Genetic Variation; Humans; Male; Middle Aged; Oxazoles; Pharmacogenetics; Phenotype; PPAR gamma; Promoter Regions, Genetic; Risk Factors; Time Factors; Tyrosine | 2007 |
Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection.
Topics: Adult; Aged; Biopsy; Double-Blind Method; Female; Hepatitis C, Chronic; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Oxazoles; PPAR gamma; Tyrosine | 2010 |
Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy.
Topics: Biomarkers; Collagen Type III; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Oxazoles; Patient Selection; Quinazolines; Thiazolidinediones; Tyrosine | 2016 |
169 other study(ies) available for oxazoles and tyrosine
| Article | Year |
|---|---|
Determination of succinylacetone and succinylacetoacetate in physiological samples as the common product 5(3)-methyl-3(5)-isoxazole propionic acid using an isotope dilution method and mass spectrometry.
Topics: Acetoacetates; Gas Chromatography-Mass Spectrometry; Heptanoates; Heptanoic Acids; Humans; Isotopes; Isoxazoles; Mass Spectrometry; Nitrogen Isotopes; Oxazoles; Tyrosine | 1989 |
Antithyroid action in rats of small doses of some naturally occurring compounds.
Topics: Animals; Antithyroid Agents; Chromatography, Paper; Diiodotyrosine; Iodides; Organ Size; Oxazoles; Rats; Thiocyanates; Thyroid Gland; Thyroxine; Triiodothyronine; Tyrosine; Vegetables | 1966 |
Effect of iodide on recovery of function of rat thyroid gland after administration of antithyroid agents.
Topics: Animals; Antithyroid Agents; Blood Proteins; Chromatography, Paper; Diiodotyrosine; Female; Iodides; Iodine; Monoiodotyrosine; Organ Size; Oxazoles; Potassium Iodide; Propylthiouracil; Protein Binding; Rats; Thyroid Gland; Thyroxine; Triiodothyronine; Tyrosine | 1968 |
Derivatization of amino acids with 1,3-dichlorotetrafluoroacetone and its use in gas chromatography.
Topics: Acetone; Amino Acids; Amino Acids, Dicarboxylic; Chemical Phenomena; Chemistry; Chromatography, Gas; Diiodotyrosine; Hydrocarbons, Halogenated; Hydroxylation; Ketones; Oxazoles; Polarography; Temperature; Tyrosine | 1974 |
Gas chromatographic behaviour of amino acid oxazolidinones. Response to flame ionization and electron capture detectors.
Topics: Acetone; Chromatography, Gas; Diiodotyrosine; Electrons; Esters; Hot Temperature; Methylation; Monoiodotyrosine; Oxazoles; Tyrosine | 1974 |
Intrinsic enzymatic activity of bovine procarboxypeptidase A S5.
Topics: Acetates; Amino Acid Sequence; Animals; Benzene Derivatives; Carbon Radioisotopes; Carboxypeptidases; Catalysis; Cattle; Chromatography, DEAE-Cellulose; Enzyme Activation; Enzyme Precursors; Glutamates; Hydrogen-Ion Concentration; Kinetics; Methane; Nitro Compounds; Oxazoles; Phenanthrolines; Phenylalanine; Protein Conformation; Sulfonic Acids; Thermolysin; Tyrosine | 1974 |
Modification of carboxyl groups in bovine carboxypeptidase A. I. Inactivation of the enzyme by N-ethyl-5-phenylisoxazolium-3'-sulfonate (Woodward's reagent K).
Topics: Animals; Binding Sites; Carbon Isotopes; Carboxypeptidases; Cattle; Chemical Phenomena; Chemistry; Chromatography, Gel; Cinnamates; Dipeptides; Ethylamines; Glycine; Hydrogen-Ion Concentration; Indoleacetic Acids; Kinetics; Lactates; Mathematics; Methoxamine; Models, Structural; Oxazoles; Phenylacetates; Phenylbutyrates; Propionates; Spectrophotometry; Sulfonic Acids; Tyrosine; Ultraviolet Rays | 1971 |
Tyrosine hydroxylase inhibition in vitro and in vivo by deoxyfrenolicin.
Topics: Acetamides; Adrenal Glands; Adrenal Medulla; Animals; Anti-Bacterial Agents; Cattle; Chemical Precipitation; Iron; Kinetics; Male; Methyltyrosines; Mixed Function Oxygenases; Monoiodotyrosine; Naphthoquinones; Oxazoles; Pteridines; Pyridines; Pyrroles; Quaternary Ammonium Compounds; Rats; Sulfates; Tritium; Tyrosine; Ultracentrifugation | 1970 |
Syntheses and hypotensive activities of 3-amino-4H-pyrrolo[3,4-c]isoxazoles and derivatives.
Topics: Animals; Antihypertensive Agents; Brain Chemistry; Catecholamines; Dogs; Male; Mixed Function Oxygenases; Myocardium; Oxazoles; Rats; Serotonin; Spectrum Analysis; Tyrosine; Ultraviolet Rays | 1968 |
Aspects of the biogenic amine-depleting activity of ethyl 3-acetamido-4H-pyrrolo-[3,4-c]isoxazole-5(6H)-carboxylate in the rat.
Topics: Aminocaproates; Animals; Brain; Brain Chemistry; Catecholamines; Female; Heart; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Oxazoles; Pargyline; Pyrroles; Rats; Serotonin; Tritium; Tyrosine | 1968 |
Inhibition of tyrosine hydroxylase in vitro and in vivo by 3-amino-pyrrolo[3,4c]isoxazole and derivatives.
Topics: Adrenal Medulla; Animals; Carbon Isotopes; Copper; Hydrogen-Ion Concentration; Iron; Kinetics; Male; Metals; Mixed Function Oxygenases; Oxazoles; Rats; Spectrophotometry; Tritium; Tyrosine | 1968 |
Inhibition of tyrosine hydroxylase by pyrroloisoxazoles.
Topics: Adrenal Medulla; Animals; Cattle; Chemical Phenomena; Chemistry; Enzymes; In Vitro Techniques; Iron; Mixed Function Oxygenases; Oxazoles; Pteridines; Pyrroles; Tyrosine | 1967 |
Modification of the carboxypeptidase A active site residue Glu-270 prevents interaction with a protein protease inhibitor from Ascaris.
Topics: Animals; Ascaris; Benzenesulfonates; Binding Sites; Carboxypeptidases; Carboxypeptidases A; Glutamates; Hydrogen-Ion Concentration; Isoxazoles; Oxazoles; Protease Inhibitors; Protein Binding; Structure-Activity Relationship; Tetranitromethane; Tyrosine | 1980 |
Platelet talin is phosphorylated by calyculin A.
Topics: Alkalies; Antibodies, Monoclonal; Blood Platelets; Electrophoresis, Polyacrylamide Gel; Humans; Isotope Labeling; Marine Toxins; Oxazoles; Peptides; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Precipitin Tests; Serine; Talin; Threonine; Tyrosine | 1995 |
Serine/threonine kinase activation in human neutrophils: relationship to tyrosine phosphorylation.
Topics: Enzyme Activation; Humans; Marine Toxins; Molecular Weight; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tyrosine | 1994 |
The structures of aplysinamisines I, II, and III; new bromotyrosine-derived alkaloids from the Caribbean sponge Aplysina cauliformis.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Porifera; Spiro Compounds; Tumor Cells, Cultured; Tyrosine | 1993 |
Protein tyrosine phosphorylation and the regulation of KCl cotransport in trout erythrocytes.
Topics: Animals; Carrier Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Genistein; Isoflavones; Isoproterenol; K Cl- Cotransporters; Marine Toxins; Oncorhynchus mykiss; Oxazoles; Phosphorylation; Potassium Chloride; Protein-Tyrosine Kinases; Staurosporine; Symporters; Tyrosine; Vanadates | 1996 |
Regulation of natural killer cell-mediated cytotoxicity by serine/threonine phosphatases: identification of a calyculin A-sensitive serine/threonine kinase.
Topics: CD28 Antigens; Cell Line; Cytotoxicity, Immunologic; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Enzyme Stability; Ionophores; Killer Cells, Natural; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
Topics: Animals; Binding Sites; Enzyme Inhibitors; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Rats; Receptor, Insulin; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha; Tyrosine | 1997 |
Disruption of insulin-like growth factor-1 signaling and down-regulation of cdc2 by SC-alphaalphadelta9, a novel small molecule antisignaling agent identified in a targeted array library.
Topics: Animals; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line; Cell Transformation, Viral; Down-Regulation; Enzyme Inhibitors; Female; Insulin-Like Growth Factor I; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pregnancy; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptor, IGF Type 1; Signal Transduction; Structure-Activity Relationship; Tyrosine; Vanadates | 1998 |
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
Topics: Administration, Oral; Aminopyridines; Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Ligands; Lipids; Male; Mice; Oxazoles; Propionates; Radioligand Assay; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Stereoisomerism; Structure-Activity Relationship; Transcription Factors; Transfection; Tyrosine | 1998 |
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.
Topics: Adipocytes; Animals; Cell Differentiation; Cell Line; DNA-Binding Proteins; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Ligands; Lipids; Mice; Oxazoles; Propionates; Radioligand Assay; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Solubility; Structure-Activity Relationship; Thiazoles; Transcription Factors; Transfection; Tyrosine | 1998 |
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent.
Topics: Administration, Oral; Animals; Benzoates; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Ligands; Lipids; Male; Mice; ortho-Aminobenzoates; Oxazoles; Radioligand Assay; Rats; Receptors, Cytoplasmic and Nuclear; Solubility; Structure-Activity Relationship; Transcription Factors; Tyrosine | 1998 |
A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Drug Screening Assays, Antitumor; Female; Ligands; Mammary Neoplasms, Experimental; Methylnitrosourea; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Tamoxifen; Transcription Factors; Tyrosine | 1999 |
Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor.
Topics: cdc25 Phosphatases; Cell Cycle; Cell Line; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Inhibitors; Oxazoles; Phosphorylation; Proto-Oncogene Proteins p21(ras); Tumor Suppressor Protein p53; Tyrosine | 1999 |
Modulation of human neutrophil responses to CD32 cross-linking by serine/threonine phosphatase inhibitors: cross-talk between serine/threonine and tyrosine phosphorylation.
Topics: Adult; Calcium; Calcium Signaling; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Neutrophil Activation; Neutrophils; Oncogene Protein v-cbl; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Receptors, IgG; Retroviridae Proteins, Oncogenic; Serine; Superoxides; Threonine; Tyrosine | 2000 |
Inhibition of protein phosphatase-1 by clavosines A and B. Novel members of the calyculin family of toxins.
Topics: Animals; Cattle; Enzyme Inhibitors; Escherichia coli; Humans; Hydrogen Bonding; Marine Toxins; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Myocardium; Organophosphates; Oxazoles; Phosphoprotein Phosphatases; Protein Binding; Protein Phosphatase 1; Recombinant Proteins; Tyrosine | 2000 |
A tyrosine-derived benzofuranone related to diazonamide A.
Topics: Animals; Benzofurans; Chromatography, High Pressure Liquid; Cricetinae; Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Oxazoles; Tyrosine | 2000 |
Suramin inhibits initiation of defense signaling by systemin, chitosan, and a beta-glucan elicitor in suspension-cultured Lycopersicon peruvianum cells.
Topics: Chitin; Chitosan; Erythrosine; Glucans; Marine Toxins; Oxazoles; Peptides; Phosphorylation; Plant Cells; Plants; Protease Inhibitors; Protein Binding; Signal Transduction; Suramin; Tyrosine | 2000 |
Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice.
Topics: Animals; Arteriosclerosis; Base Sequence; CD36 Antigens; DNA Primers; Female; Gene Expression; Humans; Insulin Resistance; Ligands; Male; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxazoles; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Receptors, LDL; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Rosiglitazone; Scavenger Receptors, Class B; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Non-thiazolidinedione insulin sensitiser shows promise.
Topics: Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Drug Industry; Humans; Hypoglycemic Agents; Multicenter Studies as Topic; Oxazoles; Thiazoles; Tyrosine | 2000 |
Potentiation of glucose uptake in 3T3-L1 adipocytes by PPAR gamma agonists is maintained in cells expressing a PPAR gamma dominant-negative mutant: evidence for selectivity in the downstream responses to PPAR gamma activation.
Topics: 3T3 Cells; Adenoviridae; Adipocytes; Animals; Benzophenones; Cell Membrane; Drug Synergism; Gene Expression; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Green Fluorescent Proteins; Hypoglycemic Agents; Insulin; Luminescent Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Mutation; Oxazoles; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Tyrosine | 2001 |
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Oxazoles; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Tyrosine | 2001 |
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; DNA-Binding Proteins; Humans; Inhibitory Concentration 50; Ligands; Models, Molecular; Molecular Sequence Data; Nuclear Receptor Co-Repressor 2; Oxazoles; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Sequence Alignment; Structure-Activity Relationship; Transcription Factors; Tyrosine | 2002 |
Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis.
Topics: Animals; Cerebellum; Cerebral Cortex; DNA-Binding Proteins; Encephalomyelitis, Autoimmune, Experimental; Female; Glycoproteins; Humans; Hypoglycemic Agents; I-kappa B Proteins; Ligands; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxazoles; Peptide Fragments; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Remission Induction; Spinal Cord; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine | 2002 |
Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.
Topics: Animals; Blood Glucose; Carrier Proteins; Energy Metabolism; Fatty Acids; Fatty Acids, Nonesterified; Homeostasis; Humans; Ion Channels; Isoenzymes; Ketones; Lactic Acid; Liver Glycogen; Mice; Mice, Knockout; Mitochondrial Proteins; Muscle, Skeletal; Oxazoles; Oxidation-Reduction; Physical Conditioning, Animal; Protein Kinases; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription Factors; Transcription, Genetic; Tyrosine; Uncoupling Protein 3 | 2002 |
Glycoprotein Ib cross-linking/ligation on echicetin-coated surfaces or echicetin-IgMkappa in stirred suspension activates platelets by cytoskeleton modulated calcium release.
Topics: Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channels; Carrier Proteins; Cell Adhesion; Cytochalasin D; Cytoskeleton; Humans; Immunoglobulin M; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Nitric Oxide; Oxazoles; Phosphorylation; Platelet Activation; Platelet Glycoprotein GPIb-IX Complex; Proteins; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidines; Tyrosine; Viper Venoms; von Willebrand Factor | 2002 |
Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Bone Marrow Cells; Cell Line; Cell Line, Transformed; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oxazoles; Peroxisome Proliferators; Peroxisomes; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Signal Transduction; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine | 2002 |
Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells.
Topics: Anilides; Aorta; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Humans; Hypoglycemic Agents; Inhibitor of Differentiation Protein 2; Muscle, Smooth, Vascular; Oxazoles; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; RNA, Messenger; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tyrosine | 2003 |
PPAR gamma-dependent anti-inflammatory action of rosiglitazone in human monocytes: suppression of TNF alpha secretion is not mediated by PTEN regulation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromones; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Monocytes; Morpholines; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins; Tyrosine | 2003 |
Subtype specific effects of peroxisome proliferator-activated receptor ligands on corepressor affinity.
Topics: Amino Acid Motifs; Binding Sites; Cells, Cultured; Crystallography, X-Ray; DNA-Binding Proteins; Fluorescence; Humans; Ligands; Models, Molecular; Molecular Structure; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Co-Repressor 2; Oxazoles; Peptide Fragments; Protein Isoforms; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Transcription Factors; Transfection; Two-Hybrid System Techniques; Tyrosine | 2003 |
Effects of a PPARgamma agonist, GI262570, on renal filtration fraction and nitric oxide level in conscious rats.
Topics: Animals; Glomerular Filtration Rate; Hypoglycemic Agents; Male; Nitrates; Nitric Oxide; Nitrites; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Renal Plasma Flow, Effective; Transcription Factors; Tyrosine | 2003 |
Synthesis of a high-affinity fluorescent PPARgamma ligand for high-throughput fluorescence polarization assays.
Topics: Animals; Binding, Competitive; Crystallography, X-Ray; Drug Evaluation, Preclinical; Fluorescence Polarization; Fluorescent Dyes; Ligands; Mice; Molecular Structure; Oxazoles; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Transcription Factors; Tyrosine | 2003 |
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.
Topics: ADAM Proteins; ADAMTS4 Protein; Alitretinoin; Cell Line; Humans; Macrophages; Matrix Metalloproteinase 9; Metalloendopeptidases; Metalloproteases; Oxazoles; Procollagen N-Endopeptidase; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Tretinoin; Tyrosine | 2003 |
Interferon regulatory factor-1 mediates PPARgamma-induced apoptosis in vascular smooth muscle cells.
Topics: Adenoviridae; Animals; Aorta; Apoptosis; Cells, Cultured; Chlorocebus aethiops; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Interferon Regulatory Factor-1; Ligands; Muscle, Smooth, Vascular; Oxazoles; Phosphoproteins; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA Stability; RNA, Messenger; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tyrosine; Up-Regulation | 2004 |
Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.
Topics: Amino Acid Sequence; Cell Line; Gene Expression; Genes, Dominant; Humans; Leucine; Ligands; Methionine; Models, Structural; Molecular Sequence Data; Monocytes; Mutation; Oxazoles; Pioglitazone; Proline; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazolidinediones; Transcription Factors; Transfection; Tyrosine; Valine | 2004 |
Regional hemodynamic effects of the N-(2-benzoylphenyl)-L-tyrosine peroxisome proliferator-activated receptor-gamma ligand, GI 262570 [(S)-2-(2-benzoylphenylamino)-3-[4-[2-(5-methyl-2-phenyl-2-oxazol-4-yl)ethoxy]phenyl]propionic acid], in conscious rats.
Topics: Acetylcholine; Animals; Hemodynamics; Indans; Male; Methoxamine; Naphthyridines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxazoles; Phentolamine; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Tyrosine | 2004 |
Synthesis of a bromotyrosine-derived natural product inhibitor of mycothiol-S-conjugate amidase.
Topics: Alkylation; Amidohydrolases; Anti-Infective Agents; Bacterial Proteins; Hydrocarbons, Fluorinated; Hydrolysis; Inhibitory Concentration 50; Kinetics; Mycobacterium tuberculosis; Oxazoles; Oximes; Structure-Activity Relationship; Tyrosine | 2004 |
Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries.
Topics: Algorithms; Animals; Barium; Benzophenones; Blood Pressure; Calcium Channels; Electrophysiology; Female; Hypoglycemic Agents; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle Cells; Muscle Tonus; Muscle, Smooth, Vascular; Oxazoles; Patch-Clamp Techniques; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Tyrosine; Vasodilation | 2005 |
GI262570, a peroxisome proliferator-activated receptor {gamma} agonist, changes electrolytes and water reabsorption from the distal nephron in rats.
Topics: Actins; Aldosterone; Amiloride; Animals; Blood Volume; Diuretics; Electrolytes; Epithelial Cells; Epithelial Sodium Channels; Gene Expression; Kidney Medulla; Kidney Tubules, Distal; Male; Nephrons; Oxazoles; PPAR gamma; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sodium; Sodium Channels; Tyrosine; Water | 2005 |
Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats.
Topics: Adiponectin; Animals; Biomarkers; Carrier Proteins; Diabetes Mellitus; Fatty Acid-Binding Proteins; Insulin; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Lipids; Male; Obesity; Oxazoles; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Rats, Zucker; Thiazolidinediones; Tyrosine | 2004 |
A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist.
Topics: alpha-Galactosidase; Anilides; Cells, Cultured; Chromans; CREB-Binding Protein; Drug Evaluation, Preclinical; Genes, Reporter; Indomethacin; Ligands; Nuclear Proteins; Oxazoles; Pioglitazone; PPAR gamma; Prostaglandin D2; Protein Binding; Rosiglitazone; Thiazolidinediones; Trans-Activators; Troglitazone; Two-Hybrid System Techniques; Tyrosine; Yeasts | 2004 |
The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Migration Inhibition; Cell Movement; Cell Survival; Glioma; Humans; Ligands; Oxazoles; PPAR gamma; Rats; Thiazolidinediones; Tyrosine | 2005 |
Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping.
Topics: Alkanesulfonates; Binding Sites; Cinnamates; Computational Biology; Humans; Ligands; Oxazines; Oxazoles; Phenylpropionates; PPAR gamma; Protein Binding; Protein Conformation; Protein Interaction Mapping; Protein Structure, Tertiary; Rosiglitazone; Solvents; Thiazoles; Thiazolidinediones; Thiazolidines; Tyrosine | 2005 |
Activation of PPARgamma enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats.
Topics: Adaptation, Physiological; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Metabolism; Gene Expression Regulation; Glucose; In Vitro Techniques; Insulin Resistance; Male; Myocardial Contraction; Myocardium; Oxazoles; PPAR gamma; Rats; Rats, Inbred Strains; Rats, Zucker; Signal Transduction; Transcriptional Activation; Triglycerides; Tyrosine | 2005 |
Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Adenosquamous; Carcinoma, Ductal; Carcinoma, Squamous Cell; Cell Differentiation; Disease Progression; Female; Gene Expression Profiling; Mammary Neoplasms, Experimental; Mice; Oxazoles; PPAR delta; PPAR gamma; Thiazoles; Tyrosine | 2005 |
Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells.
Topics: Butyrates; Cells, Cultured; Fatty Acids; Gene Expression Regulation, Enzymologic; Glucose; Humans; Insulin; Isoenzymes; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts, Skeletal; Oxazoles; Phenylurea Compounds; PPAR alpha; PPAR delta; PPAR gamma; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; RNA, Messenger; Thiazoles; Tyrosine | 2005 |
PPARgamma agonists diminish serum VEGF elevation in diet-induced insulin resistant SD rats and ZDF rats.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Diabetes Mellitus, Experimental; Diet; Dose-Response Relationship, Drug; Insulin; Insulin Resistance; Male; Mice; Oxazoles; PPAR gamma; Rats; Rats, Sprague-Dawley; Rats, Zucker; Tyrosine; Vascular Endothelial Growth Factor A | 2005 |
The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation.
Topics: Amphetamine; Animals; Behavior, Animal; CD11b Antigen; Cell Count; Diagnostic Imaging; Dopamine; Dopamine Uptake Inhibitors; Drug Interactions; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lipopolysaccharides; Motor Activity; Neuroglia; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxazoles; Rats; S100 Proteins; Stereotyped Behavior; Substantia Nigra; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Synthesis and biodistribution of (11)C-GW7845, a positron-emitting agonist for peroxisome proliferator-activated receptor-{gamma}.
Topics: Animals; Breast Neoplasms; Carbon Radioisotopes; Female; Isotope Labeling; Male; Metabolic Clearance Rate; Mice; Mice, SCID; Organ Specificity; Oxazoles; Positron-Emission Tomography; PPAR gamma; Radiopharmaceuticals; Tissue Distribution; Tyrosine | 2005 |
The diazo route to diazonamide A: studies on the tyrosine-derived fragment.
Topics: Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Models, Molecular; Molecular Structure; Oxazoles; Stereoisomerism; Tyrosine | 2005 |
Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats.
Topics: Adiponectin; Animals; Dietary Fats; Dietary Sucrose; Dose-Response Relationship, Drug; Insulin Resistance; Male; Muscle, Skeletal; Oxazoles; PPAR gamma; Rats; Rats, Sprague-Dawley; Tyrosine | 2006 |
Propofol inhibits phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in neurons.
Topics: Animals; Calcium; Marine Toxins; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Propofol; Protein Phosphatase 2; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Tyrosine | 2006 |
Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis.
Topics: Animals; Apoptosis; B-Lymphocytes; Caspases; Cell Line; Cytochromes c; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Oxazoles; Phosphorylation; PPAR gamma; Protein Kinase Inhibitors; Tyrosine | 2006 |
PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression.
Topics: Anilides; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Connective Tissue Growth Factor; Dose-Response Relationship, Drug; Gene Expression; Hepatocytes; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Ligands; Oxazoles; PPAR gamma; Prostaglandin D2; Rats; RNA, Messenger; Transforming Growth Factor beta1; Tyrosine | 2006 |
A novel dual peroxisome proliferator-activated receptors alpha and gamma agonist with beneficial effects on insulin resistance and lipid metabolism.
Topics: Adipocytes; Adipogenesis; Animals; Cell Differentiation; Diabetes Complications; Humans; Insulin Resistance; Lipid Metabolism; Male; Mice; Models, Animal; Oxazoles; PPAR alpha; PPAR gamma; Tyrosine; Up-Regulation | 2006 |
PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.
Topics: Activin Receptors, Type I; Adipocytes; Benzamides; Cell Line; Culture Media; Dioxoles; Extracellular Matrix Proteins; Gene Expression; Humans; Liver; Oxazoles; Phosphorylation; PPAR gamma; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1; Tyrosine | 2006 |
An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells.
Topics: Animals; Apoptosis; Bone Marrow Cells; Caspase Inhibitors; Caspases; Cytochromes c; Immunoblotting; Membrane Potentials; Mice; Mice, Inbred C57BL; Mitochondrial Membranes; Oxazoles; PPAR gamma; Signal Transduction; Tyrosine | 2007 |
Time-dependence of cardiomyocyte differentiation disturbed by peroxisome proliferator-activated receptor alpha inhibitor GW6471 in murine embryonic stem cells in vitro.
Topics: Animals; Cell Differentiation; Cells, Cultured; Embryonic Stem Cells; Mice; Myocytes, Cardiac; Oxazoles; p38 Mitogen-Activated Protein Kinases; PPAR alpha; Time Factors; Tyrosine | 2007 |
Co-crystal structure guided array synthesis of PPARgamma inverse agonists.
Topics: Crystallization; Ligands; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oxazoles; PPAR gamma; Tyrosine | 2007 |
Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor gamma, in colorectal adenocarcinoma.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Alternative Splicing; Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Male; Middle Aged; Oxazoles; PPAR gamma; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2007 |
An expedient formal total synthesis of (-)-diazonamide A via a powerful, stereoselective O-aryl to C-aryl migration to form the C10 quaternary center.
Topics: Animals; Heterocyclic Compounds, 4 or More Rings; Oxazoles; Stereoisomerism; Tyrosine; Urochordata | 2007 |
Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices.
Topics: Alkaloids; Animals; In Vitro Techniques; Male; Marine Toxins; Oxazoles; Phosphorylation; Prosencephalon; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; tau Proteins; Tyrosine | 2007 |
Synthesis and biological evaluation of (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: a novel series of PPAR gamma agonists.
Topics: 3T3 Cells; Adipocytes; Animals; Blood Glucose; Cell Differentiation; Chemical Phenomena; Chemistry, Physical; Chromatography, Thin Layer; Cyclization; Hypoglycemic Agents; Hypolipidemic Agents; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Inbred ICR; Oxazoles; PPAR gamma; Rats; Rats, Sprague-Dawley; Rats, Zucker; Spectrophotometry, Infrared; Structure-Activity Relationship; Tetrahydroisoquinolines; Triglycerides; Tyrosine | 2008 |
Molecular mechanics and molecular orbital simulations on specific interactions between peroxisome proliferator-activated receptor PPARalpha and plasticizer.
Topics: Amino Acid Sequence; Animals; Computer Simulation; Crystallography, X-Ray; Electrons; Esters; Humans; Isomerism; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Oxazoles; Plasticizers; PPAR alpha; Protein Structure, Tertiary; Thermodynamics; Tyrosine | 2008 |
Exposure to perfluorooctane sulfonate or fenofibrate causes PPAR-alpha dependent transcriptional responses in chicken embryo hepatocytes.
Topics: Alkanesulfonic Acids; Animals; Cell Survival; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Environmental Pollutants; Fenofibrate; Fluorocarbons; Gene Expression Regulation, Enzymologic; Hepatocytes; Lipid Metabolism; Liver; Oxazoles; PPAR alpha; RNA, Messenger; Time Factors; Transcription, Genetic; Tyrosine | 2008 |
15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation.
Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Cartilage; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Diclofenac; Dinoprostone; Down-Regulation; Enzyme Induction; Enzyme Repression; Imidazoles; Inflammation; Intramolecular Oxidoreductases; Lipocalin-2; Lipocalins; Lipopolysaccharides; Mice; NF-kappa B; Oncogene Proteins; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; PPAR alpha; PPAR gamma; Prostaglandin D2; Prostaglandin-E Synthases; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Time Factors; Tyrosine | 2008 |
Diazonamide support studies: stereoselective formation of the C10 chiral center in both the CDEFG and AEFG fragments.
Topics: Benzofurans; Heterocyclic Compounds, 4 or More Rings; Indoles; Oxazoles; Oxindoles; Stereoisomerism; Substrate Specificity; Tyrosine | 2008 |
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; Inflammation; Oxazoles; Pain; Piperidines; PPAR gamma; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Tyrosine | 2008 |
An innovative method to study target protein-drug interactions by mass spectrometry.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Drug Discovery; Hydrolysis; Ligands; Mass Spectrometry; Models, Molecular; Oxazoles; Pharmaceutical Preparations; PPAR alpha; Protein Binding; Protein Conformation; Reproducibility of Results; Tyrosine | 2009 |
PPARgamma agonists inhibit vasopressin-mediated anion transport in the MDCK-C7 cell line.
Topics: Animals; Biological Transport; Cell Line; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Dogs; Dose-Response Relationship, Drug; Epithelial Sodium Channels; Kidney; Ligands; Models, Animal; Oxazoles; Pioglitazone; PPAR gamma; RNA, Messenger; Signal Transduction; Thiazolidinediones; Tyrosine; Vasopressins | 2009 |
Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro.
Topics: Cell Growth Processes; Cells, Cultured; Cicatrix, Hypertrophic; Connective Tissue; Connective Tissue Growth Factor; Dose-Response Relationship, Immunologic; Extracellular Matrix; Fibroblasts; Humans; Oxazoles; PPAR gamma; Prostaglandin D2; Transcriptional Activation; Transforming Growth Factor beta; Tyrosine | 2009 |
[Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta1-induced connective tissue growth factor expression in rat hepatic stellate cells].
Topics: Animals; Cells, Cultured; Connective Tissue Growth Factor; Hepatic Stellate Cells; Oxazoles; PPAR gamma; Rats; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta1; Tyrosine | 2009 |
Activation of peroxisome proliferator-activated receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat.
Topics: Animals; Cyclooxygenase 2; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hemodynamics; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type II; Oxazoles; Phosphorylation; PPAR alpha; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Thiazoles; Tyrosine | 2010 |
Inhibition of Ser/Thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors.
Topics: Aniline Compounds; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Indoles; Male; Marine Toxins; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Nitriles; Okadaic Acid; Oxazoles; Phosphorylation; Protein Serine-Threonine Kinases; Quinolines; Signal Transduction; Sperm Capacitation; Sperm-Ovum Interactions; Spermatozoa; src-Family Kinases; Sulfonamides; Tyrosine | 2010 |
The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression.
Topics: 3T3 Cells; Adipocytes; Amiloride; Animals; CCAAT-Enhancer-Binding Protein-delta; Cell Differentiation; DNA-Binding Proteins; Gene Expression Regulation; Harmine; Mice; Molecular Structure; Monoamine Oxidase Inhibitors; Oxazoles; PPAR gamma; Proto-Oncogene Proteins c-ets; Signal Transduction; Sodium Channel Blockers; Transcription Factors; Tyrosine | 2010 |
Leptin induces hypertrophy through activating the peroxisome proliferator-activated receptor α pathway in cultured neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cell Culture Techniques; Cell Enlargement; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Leptin; Myocytes, Cardiac; Obesity; Oxazoles; PPAR alpha; Protein Binding; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine | 2010 |
The role of CaMKII in calcium-activated death pathways in bone marrow B cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Bone Marrow Cells; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Chelating Agents; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; Ligands; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Mice; Oxazoles; Trialkyltin Compounds; Tyrosine | 2010 |
Activation of peroxisome-proliferator-activated receptors α and γ mediates remote ischemic preconditioning against myocardial infarction in vivo.
Topics: Anilides; Animals; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxazoles; PPAR alpha; PPAR gamma; Prostaglandin D2; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2011 |
PPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI.
Topics: Adipose Tissue; Animals; Cell Line; Cholesterol; Feces; Female; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxazoles; PPAR gamma; Scavenger Receptors, Class B; Tyrosine | 2011 |
Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21.
Topics: Adipocytes; Adipose Tissue, Brown; Adrenergic beta-Agonists; Animals; Cell Line, Transformed; Cold Temperature; Dioxoles; Fibroblast Growth Factors; Male; Mice; Mice, Inbred C57BL; Oxazoles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Receptors, Adrenergic, beta-3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thermogenesis; Trans-Activators; Transcription Factors; Transcriptional Activation; Tyrosine | 2011 |
Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin-Dependent Kinase Inhibitor p27; DNA-Directed DNA Polymerase; E2F1 Transcription Factor; Fenofibrate; Flow Cytometry; Humans; Immunoblotting; Liver Neoplasms; Oxazoles; Phosphorylation; PPAR alpha; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Tumor Suppressor Proteins; Tyrosine | 2011 |
Conformationally linked interaction in the cytochrome bc(1) complex between inhibitors of the Q(o) site and the Rieske iron-sulfur protein.
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Cytochromes; Cytochromes c; Databases, Protein; Electron Spin Resonance Spectroscopy; Electron Transport Complex III; Enzyme Inhibitors; Hydrogen Bonding; Methacrylates; Models, Molecular; Molecular Structure; Mutation; Oxazoles; Polyenes; Principal Component Analysis; Protein Binding; Protein Conformation; Protein Structure, Secondary; Strobilurins; Tyrosine; Ubiquinone | 2011 |
Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Fragmentation; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Inhibitor of Apoptosis Proteins; Oxazoles; PPAR delta; PPAR gamma; Survivin; Thiazoles; Tyrosine | 2012 |
Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-α.
Topics: Alkaline Phosphatase; Animals; Antigens, Differentiation; Bone Morphogenetic Proteins; Cell Differentiation; Cell Line, Tumor; Collagen Type I; Core Binding Factor Alpha 1 Subunit; Gene Expression; Intracellular Signaling Peptides and Proteins; Mice; Osteoblasts; Osteocalcin; Oxazoles; PPAR alpha; PPAR gamma; Receptors, Tumor Necrosis Factor; Signal Transduction; Smad Proteins; Tumor Necrosis Factor-alpha; Tyrosine | 2012 |
Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation.
Topics: Animals; Anticarcinogenic Agents; Antigens, Ly; Antineoplastic Agents; Cell Line, Tumor; Genetic Predisposition to Disease; Heterozygote; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Oxazoles; Phenotype; PPAR gamma; RNA Interference; Signal Transduction; Thiazoles; Tyrosine | 2012 |
Chemical cross-linking and high-resolution mass spectrometry to study protein-drug interactions.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Esters; Hydrolysis; Ligands; Molecular Sequence Data; Nanotechnology; Oxazoles; Peptides; Pharmaceutical Preparations; PPAR alpha; Proteins; Spectrometry, Mass, Electrospray Ionization; Statistics as Topic; Succinimides; Tyrosine | 2012 |
13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages.
Topics: Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Biomarkers; Cell Line; Cholesterol; Gene Expression; Linoleic Acids; Lipoproteins; Liver X Receptors; Macrophages; Mice; Orphan Nuclear Receptors; Oxazoles; Peroxisome Proliferator-Activated Receptors; Scavenger Receptors, Class B; Transcriptional Activation; Tyrosine | 2011 |
Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration.
Topics: Animals; Arachidonic Acids; Eating; Endocannabinoids; Energy Intake; Feeding Behavior; Food Deprivation; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Knockout; Nutritional Status; Oxazoles; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Satiation; Tyrosine | 2012 |
OxLDL up-regulates Niemann-Pick type C1 expression through ERK1/2/COX-2/PPARα-signaling pathway in macrophages.
Topics: Atherosclerosis; Base Sequence; Carrier Proteins; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Lipoproteins, LDL; Macrophages; MAP Kinase Signaling System; Membrane Glycoproteins; Models, Biological; Niemann-Pick C1 Protein; Oxazoles; PPAR alpha; RNA, Messenger; RNA, Small Interfering; Tyrosine; Up-Regulation | 2012 |
Alteration of neuropathic and visceral pain in female C57BL/6J mice lacking the PPAR-α gene.
Topics: Animals; Female; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Oxazoles; PPAR alpha; Sciatic Nerve; Tyrosine; Visceral Pain | 2012 |
Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPARα-independent pathways.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cycloheximide; Down-Regulation; Epithelial Cells; Fenofibrate; Hypolipidemic Agents; Kidney Cortex; Male; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxazoles; PPAR alpha; Pyrimidines; Rabbits; Swine; Tyrosine | 2012 |
Trade-offs in defensive metabolite production but not ecological function in healthy and diseased sponges.
Topics: Animal Diseases; Animals; Anti-Bacterial Agents; Bacteria; Caribbean Region; Chromatography, High Pressure Liquid; Feeding Behavior; Isoxazoles; Oxazoles; Porifera; Spiro Compounds; Tetraodontiformes; Tyrosine | 2012 |
Effects of palmitoylethanolamide on aqueous humor outflow.
Topics: Amides; Animals; Aqueous Humor; Blotting, Western; Camphanes; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Activation; Ethanolamines; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organ Culture Techniques; Oxazoles; Palmitic Acids; Phosphorylation; Piperidines; PPAR alpha; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Swine; Trabecular Meshwork; Tyrosine | 2012 |
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; HEK293 Cells; Humans; Interferon Inducers; Interferon Regulatory Factor-3; Interferon-beta; Mice; Morpholines; Naphthalenes; Oxazoles; Poly I-C; PPAR alpha; Tyrosine | 2012 |
Design novel dual agonists for treating type-2 diabetes by targeting peroxisome proliferator-activated receptors with core hopping approach.
Topics: Binding Sites; Diabetes Mellitus, Type 2; Drug Design; Humans; Hypoglycemic Agents; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Molecular Structure; Oxazoles; PPAR alpha; PPAR gamma; Protein Structure, Tertiary; Tyrosine | 2012 |
Elaidyl-sulfamide, an oleoylethanolamide-modelled PPARα agonist, reduces body weight gain and plasma cholesterol in rats.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Amides; Animals; Blood Glucose; Cholesterol; Feeding Behavior; Gene Expression Profiling; Gene Expression Regulation; Glucose Tolerance Test; Humans; Hydrogen Bonding; Insulin; Insulin Resistance; Ligands; Liver; Male; Models, Molecular; Oleic Acids; Oxazoles; PPAR alpha; Protein Binding; Rats; Solutions; Sulfonamides; Taste; Thermogenesis; Tyrosine; Weight Gain | 2012 |
The role of PPARα in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats.
Topics: Animals; Electron Transport Complex I; Electron Transport Complex II; Hypoglycemic Agents; L-Lactate Dehydrogenase; Male; Metformin; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxazoles; PPAR alpha; Rats; Rats, Sprague-Dawley; Tyrosine | 2012 |
Pretreatment with proteasome inhibitors protects against oxidative injuries via PPARα-dependent and -independent pathways in ARPE-19 cells.
Topics: Aldehydes; Anilides; Cells, Cultured; Cysteine Proteinase Inhibitors; Electrophoretic Mobility Shift Assay; Humans; Lactones; Leupeptins; Oxazoles; Oxidative Stress; PPAR alpha; Retinal Pigment Epithelium; Tyrosine; Vitamin K 3 | 2012 |
Relationship between cyclic AMP-dependent protein tyrosine phosphorylation and extracellular calcium during hyperactivation of boar spermatozoa.
Topics: Analysis of Variance; Animals; Calcium; Calcium Chloride; Calmodulin; Cyclic AMP; Dichlororibofuranosylbenzimidazole; Extracellular Space; Flagella; Male; Marine Toxins; Oxazoles; Phosphorylation; Protein-Tyrosine Kinases; Spermatozoa; Sus scrofa; Thionucleotides; Tyrosine | 2012 |
PPARγ antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: potential translational significance.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Anilides; Animals; Anticarcinogenic Agents; Drug Synergism; Estradiol; Estrogen Receptor alpha; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Oxazoles; PPAR gamma; Precancerous Conditions; Receptors, Progesterone; Tamoxifen; Tissue Culture Techniques; Transcriptional Activation; Tyrosine | 2013 |
Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.
Topics: Amides; Animals; Anticonvulsants; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electroencephalography; Endocannabinoids; Epilepsy, Absence; Ethanolamines; Glycerides; Injections, Intraventricular; Lipid Metabolism; Male; Oxazoles; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tyrosine | 2013 |
Bromotyrosine alkaloids from the Australian marine sponge Pseudoceratina verrucosa.
Topics: Alkaloids; Animals; Australia; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Hydrocarbons, Brominated; Male; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxazoles; Porifera; Thiazoles; Tyrosine | 2013 |
PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway.
Topics: 3T3-L1 Cells; Adipocytes; AMP-Activated Protein Kinases; Animals; Benzamides; Blotting, Western; CD40 Antigens; Fenofibrate; Mice; Naphthols; NF-kappa B; Niacinamide; Oxazoles; PPAR alpha; Pyrrolidines; RNA, Messenger; Signal Transduction; Sirtuin 1; Thiocarbamates; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Monitoring conformational changes in peroxisome proliferator-activated receptor α by a genetically encoded photoamino acid, cross-linking, and mass spectrometry.
Topics: Benzophenones; Binding Sites; Butyrates; Cross-Linking Reagents; Genetic Variation; Ligands; Models, Molecular; Oxazoles; Phenylalanine; Phenylurea Compounds; PPAR alpha; Protein Binding; Protein Conformation; Protein Multimerization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine; Ultraviolet Rays | 2013 |
Fenofibrate suppresses melanogenesis in B16-F10 melanoma cells via activation of the p38 mitogen-activated protein kinase pathway.
Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Fenofibrate; Humans; Imidazoles; MAP Kinase Signaling System; Melanins; Melanoma, Experimental; Microphthalmia-Associated Transcription Factor; Oxazoles; PPAR alpha; Pyridines; Real-Time Polymerase Chain Reaction; RNA; Tyrosine | 2013 |
Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysis inhibition in kidney cancer cells.
Topics: Apoptosis; Carcinoma, Renal Cell; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase 4; Deoxyglucose; G1 Phase; Glucose; Glycolysis; Humans; Immunoblotting; Immunohistochemistry; Kidney Neoplasms; Oxazoles; PPAR alpha; Proto-Oncogene Proteins c-myc; Resting Phase, Cell Cycle; RNA Interference; Tyrosine | 2013 |
The protective effect of fenofibrate against TNF-α-induced CD40 expression through SIRT1-mediated deacetylation of NF-κB in endothelial cells.
Topics: Acetylation; Antioxidants; Benzamides; CD40 Antigens; Cells, Cultured; Fenofibrate; Human Umbilical Vein Endothelial Cells; Humans; Hypolipidemic Agents; Inflammation; Naphthols; Niacinamide; Oxazoles; PPAR alpha; Pyrrolidines; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Thiocarbamates; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2014 |
[The effect of PPARalpha signal channel on atorvastatin inhibiting MMP-9 expression in aging myocytes].
Topics: Aging; Animals; Atorvastatin; Cells, Cultured; Heptanoic Acids; Matrix Metalloproteinase 9; Muscle Cells; Oxazoles; PPAR alpha; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Tyrosine | 2013 |
QM/MM free-energy simulations of reaction in Serratia marcescens Chitinase B reveal the protonation state of Asp142 and the critical role of Tyr214.
Topics: Aspartic Acid; Chitinases; Glycosylation; Molecular Dynamics Simulation; Oxazoles; Protein Conformation; Protons; Quantum Theory; Serratia marcescens; Substrate Specificity; Tyrosine | 2014 |
Identification of the first potent, selective and bioavailable PPARα antagonist.
Topics: Animals; Butyrates; Humans; Mice; Molecular Structure; Oxazoles; Phenylurea Compounds; PPAR alpha; Propionates; Structure-Activity Relationship; Sulfonamides; Triazoles; Tyrosine | 2014 |
Cultured human periosteal-derived cells have inducible adipogenic activity and can also differentiate into osteoblasts in a perioxisome proliferator-activated receptor-mediated fashion.
Topics: Benzamides; Cell Differentiation; Cells, Cultured; Humans; Osteoblasts; Oxazoles; Periosteum; Peroxisome Proliferator-Activated Receptors; Pioglitazone; PPAR alpha; PPAR gamma; Pyridines; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones; Tyrosine | 2014 |
PPARα autocrine regulation of Ca²⁺-regulated exocytosis in guinea pig antral mucous cells: NO and cGMP accumulation.
Topics: Animals; Autocrine Communication; Butyrates; Calcium; Cyclic GMP; Exocytosis; Gastric Mucosa; Goblet Cells; Guinea Pigs; Male; Nitric Oxide; Oxazoles; Phenylurea Compounds; PPAR alpha; Pyloric Antrum; Tyrosine | 2014 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morpholines; Naphthalenes; Oxazoles; Pentylenetetrazole; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Thiazolidinediones; Tyrosine | 2015 |
Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.
Topics: Animals; Animals, Newborn; Butyryl-CoA Dehydrogenase; Cardiomegaly; Disease Models, Animal; Fatty Acids; Fenofibrate; Flavonoids; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Myocytes, Cardiac; Oxazoles; Phenylephrine; Phosphorylation; PPAR alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2015 |
Palmitoylethanolamide Regulates Production of Pro-Angiogenic Mediators in a Model of β Amyloid-Induced Astrogliosis In Vitro.
Topics: Adenosine Triphosphate; Amides; Amyloid beta-Peptides; Animals; Astrocytes; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Ethanolamines; Gliosis; Humans; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Oxazoles; p38 Mitogen-Activated Protein Kinases; Palmitic Acids; Peptide Fragments; PPAR alpha; Rats; S100 Calcium Binding Protein beta Subunit; Tyrosine; Vascular Endothelial Growth Factor A | 2015 |
PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth.
Topics: Animals; Carcinoma, Renal Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Kidney Tubules; Metabolic Networks and Pathways; Mice; Mice, Nude; Organ Specificity; Oxazoles; Phosphorylation; PPAR alpha; Proto-Oncogene Proteins c-myc; RNA, Small Interfering; Signal Transduction; Tyrosine; Xenograft Model Antitumor Assays | 2015 |
Lack of sterol regulatory element binding factor-1c imposes glial Fatty Acid utilization leading to peripheral neuropathy.
Topics: Analysis of Variance; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Fatty Acids; Metabolomics; Mice; Mice, Knockout; Microarray Analysis; Microscopy, Electron, Transmission; Myelin Sheath; Neuroglia; Oxazoles; Peripheral Nervous System Diseases; PPAR alpha; Real-Time Polymerase Chain Reaction; Sterol Regulatory Element Binding Protein 1; Tyrosine | 2015 |
PPARα agonists inhibit inflammatory activation of macrophages through upregulation of β-defensin 1.
Topics: Animals; Anti-Inflammatory Agents; beta-Defensins; Cell Line; Culture Media, Conditioned; Dose-Response Relationship, Drug; Fenofibrate; Gemfibrozil; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Oxazoles; PPAR alpha; RNA Interference; Signal Transduction; Toll-Like Receptor 4; Transfection; Tyrosine; Up-Regulation | 2015 |
Herbal composition Gambigyeongsinhwan (4) from Curcuma longa, Alnus japonica, and Massa Medicata Fermentata inhibits lipid accumulation in 3T3-L1 cells and regulates obesity in Otsuka Long-Evans Tokushima Fatty rats.
Topics: 3T3-L1 Cells; Alnus; Animals; Anti-Obesity Agents; CCAAT-Enhancer-Binding Proteins; Curcuma; Drugs, Chinese Herbal; Fatty Acid-Binding Proteins; Lipid Metabolism; Male; Medicine, Korean Traditional; Mice; Obesity; Oxazoles; Phytotherapy; Plant Extracts; Plant Preparations; PPAR alpha; PPAR gamma; Rats, Inbred OLETF; RNA, Messenger; Triglycerides; Tyrosine; Weight Gain | 2015 |
Peroxisome Proliferator-Activated Receptor-α Inhibition Protects Against Doxorubicin-Induced Cardiotoxicity in Mice.
Topics: Animals; Atrial Function, Left; Benzoxazines; Cannabinoid Receptor Agonists; Cardiotonic Agents; Cardiotoxicity; Cytoprotection; Disease Models, Animal; Doxorubicin; Heart Diseases; Male; Malondialdehyde; Mice, Inbred BALB C; Morpholines; Myocardial Contraction; Myocytes, Cardiac; Naphthalenes; Oxazoles; PPAR alpha; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2016 |
Connecting Tyrosine and Tryptophan Units of Diazonamide A and Azonazine by a Diastereodivergent Arylative Dearomatization.
Topics: Catalysis; Dipeptides; Heterocyclic Compounds, 4 or More Rings; Indoles; Molecular Structure; Onium Compounds; Oxazoles; Pyrroles; Stereoisomerism; Tryptophan; Tyrosine | 2015 |
BML-111 Attenuates Renal Ischemia/Reperfusion Injury Via Peroxisome Proliferator-Activated Receptor-α-Regulated Heme Oxygenase-1.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cell Line; Creatinine; Glucuronidase; Heme Oxygenase-1; Heptanoic Acids; Imidazoles; Leucyl Aminopeptidase; Male; Malondialdehyde; Oxazoles; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; PPAR alpha; Promoter Regions, Genetic; Protoporphyrins; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lipoxin; Reperfusion Injury; RNA, Messenger; Tyrosine | 2016 |
Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Biomarkers; Cell Proliferation; Disease Models, Animal; Doxorubicin; Energy Metabolism; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucose; Humans; Mice; Mitochondria; Myocytes, Cardiac; Oxazoles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Pyrimidines; Reactive Oxygen Species; Tyrosine; Up-Regulation | 2015 |
Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-α/sirtuin 1/PGC-1α pathway.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Carbazoles; Cell Line; Fenofibrate; Heart Atria; Humans; Male; Middle Aged; Oxazoles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Rabbits; Sirtuin 1; Tyrosine | 2016 |
Serum Natriuretic Peptides as Differential Biomarkers Allowing for the Distinction between Physiologic and Pathologic Left Ventricular Hypertrophy.
Topics: Animals; Biomarkers; Cardiotoxicity; Diagnosis, Differential; Hypertrophy, Left Ventricular; Male; Natriuretic Peptides; Oxazoles; PPAR gamma; Rats, Sprague-Dawley; Swimming; Tyrosine; Ventricular Function, Left; Ventricular Remodeling | 2017 |
PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression.
Topics: Alkanesulfonic Acids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Brain; Capillaries; Clofibrate; Fasting; Fluorocarbons; Gene Expression Regulation; Linoleic Acid; Male; Mice, Inbred C57BL; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oxazoles; PPAR alpha; Rats, Sprague-Dawley; Tyrosine | 2017 |
PPARα induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca(2+)-regulated exocytosis.
Topics: Acetylcholine; Animals; Butyrates; Calcium; Exocytosis; Gastric Mucosa; Goblet Cells; Guinea Pigs; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Oxazoles; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Phosphorylation; PPAR alpha; Protein Transport; Proto-Oncogene Proteins c-akt; Tyrosine | 2016 |
Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation.
Topics: Adipocytes; Adipogenesis; Animals; Cell Line; Complement C3a; Complement Factor D; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Oxazoles; Peroxisome Proliferator-Activated Receptors; Receptors, Complement; Signal Transduction; Small Molecule Libraries; Transcriptome; Tyrosine | 2016 |
Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.
Topics: Acyltransferases; Anilides; Animals; Blotting, Northern; Caco-2 Cells; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Computational Biology; HT29 Cells; Humans; Kidney Tubules, Proximal; Liver; Mice; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Rats; Real-Time Polymerase Chain Reaction; Rosiglitazone; Sulfones; Thiazoles; Thiazolidinediones; Thiophenes; Tyrosine | 2016 |
Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway.
Topics: Anilides; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Enzyme Activation; Epithelial-Mesenchymal Transition; ErbB Receptors; G1 Phase Cell Cycle Checkpoints; Glycogen Synthase Kinase 3 beta; Humans; Neoplasm Invasiveness; Oxazoles; PPAR gamma; Proto-Oncogene Proteins c-akt; Simvastatin; Tyrosine; Urinary Bladder; Urinary Bladder Neoplasms | 2016 |
The effects of herbal composition Gambigyeongsinhwan (4) on hepatic steatosis and inflammation in Otsuka Long-Evans Tokushima fatty rats and HepG2 cells.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, Animal; Fenofibrate; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatitis; Hepatocytes; Humans; Hypolipidemic Agents; Inflammation Mediators; Lipids; Lipogenesis; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Oxazoles; Plant Extracts; PPAR alpha; Rats, Inbred OLETF; RNA, Messenger; Transfection; Tyrosine | 2017 |
The Degradation Chemistry of Farglitazar and Elucidation of the Oxidative Degradation Mechanisms.
Topics: Chemistry, Pharmaceutical; Hot Temperature; Humidity; Hydrolysis; Light; Oxazoles; Oxidation-Reduction; Photochemical Processes; Tyrosine | 2017 |
In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Local; Animals; Benzamides; Bridged Bicyclo Compounds; Cocaine; Conditioning, Operant; Disease Models, Animal; Fenofibrate; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Oxazoles; PPAR alpha; Pyrimidines; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine | 2017 |
Effects of PPARα inhibition in head and neck paraganglioma cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspase 6; Caspase 7; Caspases; Caspases, Initiator; Cell Cycle; Cell Survival; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Immunohistochemistry; Oxazoles; PPAR alpha; Pyrimidines; Tumor Cells, Cultured; Tyrosine; Wound Healing | 2017 |
The interaction between alpha 7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α represents a new antinociceptive signaling pathway in mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amides; Animals; Azabicyclo Compounds; Benzamides; Bridged Bicyclo Compounds; Cannabinoid Receptor Antagonists; Ethanolamines; Furans; Male; Mice; Mice, Inbred ICR; Nicotinic Antagonists; Nociception; Oxazoles; Pain Measurement; Palmitic Acids; PPAR alpha; Receptor Cross-Talk; Signal Transduction; Tyrosine | 2017 |
A Systems Biology Approach to Investigating Sex Differences in Cardiac Hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Female; Gene Expression Regulation; Gene Regulatory Networks; Male; Mice, Inbred C57BL; MicroRNAs; Myocardium; Oxazoles; PPAR alpha; Protein Interaction Maps; RNA, Messenger; Sex Characteristics; Sex Factors; Signal Transduction; Systems Biology; Time Factors; Tyrosine | 2017 |
Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Carbazoles; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fenclonine; Fluoxetine; Gemfibrozil; Hippocampus; Immobility Response, Tonic; Indole Alkaloids; Male; Membrane Glycoproteins; Mice; Motor Activity; Oxazoles; Protein-Tyrosine Kinases; RNA, Small Interfering; Serotonin; Signal Transduction; Tyrosine | 2018 |
N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.
Topics: Animals; Brain Injuries, Traumatic; Cerebral Cortex; Conditioning, Classical; Glycine; Male; Mecamylamine; Mice; Nicotine; Oleic Acids; Oxazoles; PPAR alpha; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine | 2019 |
2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Astrocytes; Behavior, Animal; Cyclooxygenase 2; Cytokines; Disease Models, Animal; DNA Damage; Dopamine Plasma Membrane Transport Proteins; Inflammation; Mice, Inbred C57BL; Microglia; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Nitrosative Stress; Oxazoles; Oxidative Stress; Parkinson Disease; Poly Adenosine Diphosphate Ribose; Transcription Factor RelA; Tyrosine; Tyrosine 3-Monooxygenase | 2018 |
A role for peroxisome proliferator-activated receptor α in anticonvulsant activity of docosahexaenoic acid against seizures induced by pentylenetetrazole.
Topics: Animals; Anticonvulsants; Docosahexaenoic Acids; Injections, Intraventricular; Male; Mice; Oxazoles; Pentylenetetrazole; PPAR alpha; Seizures; Tyrosine | 2018 |
Naturally occurring 3RS, 7R, 11R-phytanic acid suppresses in vitro T-cell production of interferon-gamma.
Topics: A549 Cells; Animals; Cell Differentiation; Female; Gene Expression Regulation; Genes, Reporter; Humans; Immunologic Factors; Interferon-gamma; Luciferases; Lymphocyte Activation; Mice; Mice, Inbred C57BL; NF-kappa B; Oxazoles; Phytanic Acid; Phytohemagglutinins; PPAR alpha; Primary Cell Culture; RNA, Messenger; Signal Transduction; Spleen; T-Box Domain Proteins; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine | 2018 |
Selective peroxisome proliferator-activated receptor-α modulator K-877 regulates the expression of ATP-binding cassette transporter A1 in pancreatic beta cells.
Topics: Animals; ATP Binding Cassette Transporter 1; Benzoxazoles; Butyrates; Cell Line, Tumor; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Glucose; Glucose Intolerance; Humans; Hypolipidemic Agents; Insulin; Insulin-Secreting Cells; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Rats; RNA, Messenger; Tyrosine | 2018 |
Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Screening Assays, Antitumor; Humans; Metformin; Oxazoles; Paraganglioma; Tyrosine | 2018 |
Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.
Topics: Animals; Apolipoprotein A-II; Bezafibrate; Biometry; Blotting, Western; Butyrates; Clofibrate; Collagen Type I; Disease Models, Animal; Electroretinography; Fluorescent Antibody Technique, Indirect; Guinea Pigs; Intraocular Pressure; Malate Dehydrogenase; Myopia; Oxazoles; Phenylurea Compounds; PPAR alpha; Refraction, Ocular; Sensory Deprivation; Tyrosine | 2018 |
Cyanidin Increases the Expression of Mg
Topics: Animals; Anthocyanins; Cation Transport Proteins; Cell Line; Colon; Epithelial Cells; Glucosides; Intestinal Mucosa; Magnesium; Magnesium Deficiency; Mice; Oxazoles; Phytochemicals; PPAR alpha; RNA, Messenger; TRPM Cation Channels; Tyrosine; Up-Regulation | 2019 |
Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound.
Topics: Amides; Analgesics; Animals; Cannabinoids; Dronabinol; Ethanolamines; Iodoacetic Acid; Male; Motor Activity; Osteoarthritis; Oxazoles; Palmitic Acids; PPAR alpha; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Tyrosine | 2019 |
Phytanic acid activates PPARα to promote beige adipogenic differentiation of preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes, Beige; Adipogenesis; AMP-Activated Protein Kinases; Animals; Cell Differentiation; Gene Knockdown Techniques; Mice; Mitochondria; Oxazoles; Oxygen; Phosphorylation; Phytanic Acid; PPAR alpha; Receptors, Adrenergic, beta-3; Tyrosine | 2019 |
Molecular Modeling Approach to Study the PPARγ-Ligand Interactions.
Topics: Humans; Hypoglycemic Agents; Ligands; Molecular Docking Simulation; Oxazoles; PPAR gamma; Protein Conformation; Quantitative Structure-Activity Relationship; Rosiglitazone; Tyrosine | 2019 |
Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3K/PPARα pathway in HepG2 cells.
Topics: Azo Compounds; Chromones; Gene Expression Regulation; Hep G2 Cells; Humans; Imidazoles; Lipid Droplets; Morpholines; Oleic Acid; Oxazoles; Perilipin-5; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; PPAR alpha; Pyridines; Staining and Labeling; Sulfones; Thiophenes; Tyrosine | 2019 |
Pharmacological Blockade of PPAR Isoforms Increases Conditioned Fear Responding in the Presence of Nociceptive Tone.
Topics: Analgesia; Anilides; Animals; Conditioning, Psychological; Extinction, Psychological; Fear; Formaldehyde; Freezing Reaction, Cataleptic; Gene Expression; Male; Nociceptive Pain; Oxazoles; PPAR alpha; PPAR delta; PPAR gamma; PPAR-beta; Rats; Rats, Sprague-Dawley; Sulfones; Thiophenes; Tyrosine | 2020 |
Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway.
Topics: Amides; Amidohydrolases; Animals; Anti-Inflammatory Agents; beta Carotene; Cytokines; Enzyme Inhibitors; Ethanolamines; Inflammation; Lipopolysaccharides; Mice; Nitric Oxide; Oxazoles; Palmitic Acids; PPAR alpha; RAW 264.7 Cells; Tyrosine | 2020 |
Docosahexaenoic acid and oleic acid induce altered DNA methylation of individual CpG loci in Jurkat T cells.
Topics: CpG Islands; DNA Methylation; Docosahexaenoic Acids; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Humans; Jurkat Cells; Oleic Acid; Oxazoles; Sequence Analysis, DNA; Transcription Factors; Tyrosine; Zinc Fingers | 2020 |
MG53 Protects against Sepsis-Induced Myocardial Dysfunction by Upregulating Peroxisome Proliferator-Activated Receptor-
Topics: Animals; Apoptosis; Humans; Inflammation; Models, Biological; Muscle Proteins; Myocardium; Myocytes, Cardiac; Oxazoles; Oxidative Stress; PPAR alpha; Protective Agents; Rats, Sprague-Dawley; Sepsis; Survival Analysis; Tyrosine; Up-Regulation; Vesicular Transport Proteins | 2020 |
A PPAR-α agonist protects the non-adrenergic, non-cholinergic inhibitory system of guinea pig trachea from the effect of inhaled ammonium persulphate: a pilot study.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Ammonium Sulfate; Animals; Electric Stimulation; Guinea Pigs; Isoproterenol; Male; Muscle Relaxation; Nerve Fibers; Oxazoles; Pilot Projects; PPAR alpha; Pyrimidines; Random Allocation; Trachea; Tyrosine | 2020 |
Co-option of PPARα in the regulation of lipogenesis and fatty acid oxidation in CLA-induced hepatic steatosis.
Topics: Acetyl-CoA Carboxylase; Acyl-CoA Dehydrogenase; Animals; Cells, Cultured; Disease Models, Animal; Fatty Acids; Gene Expression Regulation, Enzymologic; Hepatocytes; Histones; Insulin Resistance; Linoleic Acids, Conjugated; Lipogenesis; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxazoles; Oxidation-Reduction; PPAR alpha; Signal Transduction; Transcriptional Activation; Tyrosine | 2021 |
Comparison of PPAR Ligands as Modulators of Resolution of Inflammation, via Their Influence on Cytokines and Oxylipins Release in Astrocytes.
Topics: Anilides; Animals; Anti-Inflammatory Agents; Astrocytes; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fenofibrate; Interleukin-10; Lipopolysaccharides; MAP Kinase Kinase 4; Oxazoles; Oxylipins; p38 Mitogen-Activated Protein Kinases; PPAR gamma; PPAR-beta; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Tumor Necrosis Factor-alpha; Tyrosine | 2020 |
Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPARα/SREBP-1c/FAS/GPAT/AMPK signal pathway.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Dibutyl Phthalate; fas Receptor; Gene Expression Regulation; Glycerol-3-Phosphate O-Acyltransferase; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Liver; Male; Oxazoles; PPAR alpha; Rats; Rats, Sprague-Dawley; Ribonucleotides; Sterol Regulatory Element Binding Protein 1; Tyrosine | 2021 |
Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α.
Topics: Animals; Choline; Diet; Lipid Metabolism; Liver; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Oxazoles; PPAR alpha; Silybin; Tyrosine | 2021 |