oxazoles has been researched along with telomestatin in 64 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 36 (56.25) | 29.6817 |
2010's | 26 (40.63) | 24.3611 |
2020's | 2 (3.13) | 2.80 |
Authors | Studies |
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Furihata, K; Hayakawa, Y; Matsuo, K; Ohtani, T; Seto, H; Shin-ya, K; Wierzba, K; Yamada, Y | 1 |
Hurley, LH; Kim, MY; Shin-Ya, K; Vankayalapati, H; Wierzba, K | 1 |
Gleason-Guzman, M; Hurley, LH; Izbicka, E; Kim, MY; Nishioka, D | 1 |
Nakajima, A; Ohyashiki, JH; Ohyashiki, K; Sashida, G; Shimamoto, T; Shin-Ya, K; Sumi, M; Tauchi, T | 1 |
De Pauw, E; Gabelica, V; Rosu, F; Shin-ya, K | 1 |
Gomez, D; Lacroix, L; Lemarteleur, T; Mailliet, P; Mergny, JL; Riou, JF | 1 |
Anderson, KC; Hurley, LH; Koley, H; Li, C; Munshi, NC; Shammas, MA; Shmookler Reis, RJ | 1 |
Gotoh, A; Nakajima, A; Ohyashiki, JH; Ohyashiki, K; Sashida, G; Shin-Ya, K; Sumi, M; Tauchi, T | 1 |
Gomez, D; Lemarteleur, T; Mergny, JL; Paterski, R; Riou, JF; Shin-Ya, K | 1 |
Shin-ya, K | 2 |
Bashyam, S; Gokhale, V; Hurley, LH; Seenisamy, J; Shin-Ya, K; Siddiqui-Jain, A; Streiner, N; Sun, D; Vankayalapati, H; White, E; Wilson, WD | 1 |
Bashyam, S; Hurley, LH; Kim, MY; Rezler, EM; Seenisamy, J; White, E; Wilson, WD | 1 |
Atkins, JM; Vedejs, E | 1 |
Guo, K; Hurley, LH; Rusche, JJ; Sun, D | 1 |
Binz, N; Grotzer, MA; Rivera, P; Shalaby, T; Shin-ya, K | 1 |
Ide, T; Seimiya, H; Shin-Ya, K; Tahara, H; Tsuruo, T; Yamada, H | 1 |
Hurley, LH; Liu, W; Sun, D | 1 |
Shin-ya, K; Takahashi, H; Tamura, K; Zhang, L | 1 |
Ohyashiki, JH; Ohyashiki, K; Okabe, S; Sashida, G; Shin-ya, K; Sumi, M; Tauchi, T | 1 |
Douarre, C; Giraud-Panis, MJ; Gomez, D; Kaplan, H; Koebel, P; Kolkes, A; Macadré, J; O'Donohue, MF; Riou, JF; Shin-ya, K; Wenner, T | 1 |
Doi, T; Shin-ya, K; Takahashi, T; Yoshida, M | 1 |
Marson, CM; Saadi, M | 1 |
Brassart, B; Douarre, C; El Khoury, V; Gomez, D; Morjani, H; O'Donohue, MF; Riou, JF; Shin-Ya, K; Trentesaux, C; Wenner, T | 1 |
De Cian, A; Guittat, L; Mergny, JL; Riou, JF; Shin-ya, K | 1 |
Autexier, C; Fakhoury, J; Nimmo, GA | 1 |
Kazuo, SY | 1 |
Ohyashiki, JH; Ohyashiki, K; Tauchi, T | 1 |
Agrawal, S; Maiti, S; Ojha, RP | 1 |
Bertram, A; Deeley, J; Pattenden, G | 1 |
Gaynutdinov, TI; Neumann, RD; Panyutin, IG | 1 |
Huppert, JL | 1 |
Bétous, R; Biard, DS; Cazaux, C; Hoffmann, JS; Pillaire, MJ; Puget, N; Rey, L; Selves, J; Shin-ya, K; Vasquez, KM; Wang, G | 1 |
Arnoult, N; Londoño-Vallejo, JA; Shin-Ya, K | 1 |
Guittat, L; Riou, JF; Shin-ya, K; Sidibe, A; Temime-Smaali, N; Trentesaux, C | 1 |
Iida, K; Nagasawa, K; Shin-Ya, K; Tera, M | 1 |
Anno, K; Chayama, K; Ide, T; Ono, T; Tahara, H; Waki, K | 1 |
Brosh, RM; Deakyne, JS; Kitao, H; Leonard, T; Mazin, AV; Shin-Ya, K; Sommers, JA; Suhasini, AN; Wu, Y | 1 |
Nielsen, MC; Ulven, T | 1 |
Doi, T; Nagasawa, K; Shibata, K; Shin-ya, K; Takagi, M; Takahashi, T; Tera, M; Yoshida, M | 1 |
Garner, TP; Linder, J; Moody, CJ; Searle, MS; Williams, HE | 1 |
Aggarwal, M; Brosh, RM; Shoemaker, RH; Sommers, JA | 1 |
Amemiya, Y; Furunaga, Y; Iida, K; Ikebukuro, K; Nagasawa, K; Nakamura, C; Tera, M | 1 |
Guédin-Beaurepaire, A; Hamon, F; Largy, E; Mergny, JL; Monchaud, D; Nguyen, CH; Riou, JF; Rouchon-Dagois, M; Sidibe, A; Teulade-Fichou, MP | 1 |
Ashbridge, B; Balasubramanian, S; Dhakal, S; Koirala, D; Mao, H; Rodriguez, R; Sannohe, Y; Sugiyama, H | 1 |
Demir, H; Hu, B; Joshi, K; Mazumder, S; Miyazaki, T; Nakano, I; Okabe, S; Pan, Y; Purohit, D; Seimiya, H; Shin-ya, K; Viapiano, M; Yamori, T | 1 |
Chae, J; Han, S; Park, HJ; Vy Thi Le, T | 1 |
Alcaro, S; Artese, A; Costa, G; Distinto, S; Moraca, F; Ortuso, F; Parrotta, L | 1 |
Brosh, RM; Kisker, C; Kitao, H; Kuper, J; Loiland, JA; Sommers, JA; Wu, Y | 1 |
Beier, F; Bérubé, NG; Edwards, M; Jiang, Y; Li, JR; Shin-ya, K; Solomon, LA; Watson, LA | 1 |
Iida, K; Majima, S; Nagasawa, K; Nakamura, T; Seimiya, H | 1 |
Chung, WJ; Heddi, B; Iida, K; Nagasawa, K; Phan, AT; Tera, M | 1 |
Calvo, EP; Wasserman, M | 1 |
Alberti, P; Bourdoncle, A; Delagoutte, E; Gueddouda, NM; Lavrik, O; Mendoza, O; Petruseva, I; Riou, JF; Safa, L; Saintomé, C; Thiébaut, F | 1 |
Mulholland, K; Wu, C | 1 |
Balci, H; Iida, K; Ma, Y; Maleki, P; Nagasawa, K | 1 |
Abraham Punnoose, J; Li, Y; Ma, Y; Mandal, S; Mao, H; Nagasawa, K; Sakuma, M | 1 |
Amagai, K; Eguchi, T; Hashimoto, J; Ikeda, H; Izumikawa, M; Kozone, I; Kudo, F; Nakamura, T; Osada, H; Shin-Ya, K; Takahashi, S | 1 |
Iida, K; Ma, Y; Nagasawa, K; Nakamura, T; Nakano, I; Okabe, S; Sasaki, S; Seimiya, H; Shin-Ya, K; Yamori, T; Yoshida, H | 1 |
Abe, T; Awate, S; Bellani, MA; Bharti, SK; Bradley, L; Branzei, D; Brosh, RM; Khan, I; King, GA; Kitao, H; Kobayashi, K; Neuman, KC; Seol, Y; Shin-Ya, K; Sommers, JA; Vidhyasagar, V; Wold, MS; Wu, Y | 1 |
Cui, Y; Ghimire, C; Iida, K; Jonchhe, S; Mao, H; McCool, M; Nagasawa, K; Park, S; Sasaki, S; Sugiyama, H | 1 |
Ermert, P; Luther, A; Obrecht, D; Zbinden, P | 1 |
Li, Y; Lu, L; Mandal, S; Mao, H; Pandey, S; Shelley, JT; Young, MD | 1 |
Ishikawa, R; Ma, Y; Nagasawa, K; Sasaki, S; Tera, M; Yasuda, M | 1 |
8 review(s) available for oxazoles and telomestatin
Article | Year |
---|---|
[Telomerase inhibitor, telomestatin, a specific mechanism to interact with telomere structure].
Topics: Oxazoles; Telomerase; Telomere | 2004 |
Novel antitumor and neuroprotective substances discovered by characteristic screenings based on specific molecular targets.
Topics: Antineoplastic Agents; Endoplasmic Reticulum Chaperone BiP; Gene Expression; Heat-Shock Proteins; Humans; Macrolides; Molecular Chaperones; Molecular Structure; Neuroprotective Agents; Oligosaccharides; Oxazoles; Pyrroles; Receptors, Glutamate; Telomerase | 2005 |
Harnessing telomerase in cancer therapeutics.
Topics: Animals; Antineoplastic Agents; Genetic Therapy; Humans; Immunotherapy; Models, Chemical; Models, Genetic; Neoplasms; Oligonucleotides, Antisense; Oxazoles; Promoter Regions, Genetic; RNA; Telomerase | 2007 |
[Studies on bioactive substances of microbial origin that were screened based on molecular targets].
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Macrolides; Molecular Chaperones; Neoplasms; Oligosaccharides; Oxazoles; Telomerase | 2007 |
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes.
Topics: Acridines; Base Pairing; Binding Sites; Chemistry, Pharmaceutical; G-Quadruplexes; Gene Targeting; Nucleic Acid Conformation; Nucleic Acids; Oxazoles; Porphyrins; Telomerase; Transcription, Genetic | 2008 |
Macrocyclic G-quadruplex ligands.
Topics: Antineoplastic Agents; G-Quadruplexes; Humans; Ligands; Macrocyclic Compounds; Oxazoles; Porphyrins; Telomere | 2010 |
G-quadruplex binding ligands: from naturally occurring to rationally designed molecules.
Topics: Acridines; Anthraquinones; Berberine; DNA; Drug Design; G-Quadruplexes; Humans; Indole Alkaloids; Ligands; Oxazoles; Porphyrins; Quinolines; RNA | 2012 |
Frontier Between Cyclic Peptides and Macrocycles.
Topics: Biological Products; Cyclization; Depsipeptides; Humans; Lactones; Macrocyclic Compounds; Oxazoles; Peptide Library; Peptides, Cyclic; Permeability; Protein Conformation; Spiro Compounds; Streptogramins; Thiazoles | 2019 |
56 other study(ies) available for oxazoles and telomestatin
Article | Year |
---|---|
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus.
Topics: Enzyme Inhibitors; HIV; Humans; Leukemia Virus, Murine; Magnetic Resonance Spectroscopy; Molecular Structure; Oxazoles; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Fast Atom Bombardment; Streptomyces; Telomerase; Tumor Cells, Cultured | 2001 |
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.
Topics: DNA; Enzyme Inhibitors; Guanine; Humans; Models, Molecular; Nucleic Acid Conformation; Oxazoles; Repetitive Sequences, Nucleic Acid; Substrate Specificity; Telomerase | 2002 |
The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures.
Topics: Anaphase; Animals; Cell Line, Transformed; DNA; Enzyme Inhibitors; Humans; Macromolecular Substances; Nucleic Acid Conformation; Oxazoles; Porphyrins; Potassium; Sea Urchins; Single-Strand Specific DNA and RNA Endonucleases; Sodium; Substrate Specificity; Telomerase; Telomere | 2003 |
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways.
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Division; DNA Repair; DNA-Binding Proteins; Humans; Leukemia; Oxazoles; Protein Serine-Threonine Kinases; Telomerase; Telomere; Tumor Suppressor Proteins | 2003 |
Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry.
Topics: DNA; G-Quadruplexes; Humans; Kinetics; Models, Molecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligonucleotides; Oxazoles; Spectrometry, Mass, Electrospray Ionization; Telomere; Temperature | 2003 |
Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.
Topics: Acridines; Alternative Splicing; Cell Line, Tumor; Down-Regulation; Humans; Introns; Kinetics; Ligands; Oxazoles; Quinolinium Compounds; RNA; Substrate Specificity; Telomerase; Transcription, Genetic; Triazines | 2004 |
Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma.
Topics: Apoptosis; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; DNA Repair; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Multiple Myeloma; Oligonucleotide Array Sequence Analysis; Oxazoles; Recombination, Genetic; Telomerase; Telomere; Time Factors | 2004 |
A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity in acute myeloid leukemia.
Topics: Acute Disease; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Cytarabine; Daunorubicin; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Humans; Leukemia, Myeloid; Male; Middle Aged; Oxazoles; Telomerase; Telomere; U937 Cells | 2004 |
Interaction of telomestatin with the telomeric single-strand overhang.
Topics: Base Sequence; Binding, Competitive; Cell Line; Cell Survival; DNA; DNA, Single-Stranded; G-Quadruplexes; Humans; Nucleic Acid Conformation; Oxazoles; Sulfuric Acid Esters; Telomere | 2004 |
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.
Topics: Binding, Competitive; DNA; DNA, Single-Stranded; G-Quadruplexes; Genes, myc; Guanine; HeLa Cells; Humans; Models, Molecular; Nucleic Acid Conformation; Oxazoles; Porphyrins; Promoter Regions, Genetic; Selenium Compounds; Substrate Specificity; Surface Plasmon Resonance; Telomere | 2005 |
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure.
Topics: Binding Sites; Circular Dichroism; DNA; G-Quadruplexes; Humans; Ligands; Molecular Structure; Oligonucleotides; Oncogene Proteins; Oxazoles; Polymerase Chain Reaction; Porphyrins; Potassium; Selenium Compounds; Sodium; Substrate Specificity; Surface Plasmon Resonance; Telomere | 2005 |
A two-stage iterative process for the synthesis of poly-oxazoles.
Topics: Combinatorial Chemistry Techniques; Molecular Structure; Oxazoles; Polymers | 2005 |
Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents.
Topics: Base Sequence; Circular Dichroism; Deoxyribonuclease I; DNA; DNA Footprinting; G-Quadruplexes; Guanine; Humans; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Oxazoles; Polydeoxyribonucleotides; Porphyrins; Potassium Chloride; Promoter Regions, Genetic; Purines; Pyrimidines; Single-Strand Specific DNA and RNA Endonucleases; Vascular Endothelial Growth Factor A | 2005 |
Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells.
Topics: Apoptosis; Cell Division; Cell Line, Tumor; Cell Proliferation; Child; Enzyme Inhibitors; Humans; Neuroblastoma; Oxazoles; Proto-Oncogene Mas; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Telomerase; Telomere | 2005 |
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.
Topics: Anaphase; Breast Neoplasms; Cell Death; Dose-Response Relationship, Drug; Epithelial Cells; Female; Fibroblasts; HeLa Cells; Humans; Nuclear Proteins; Oxazoles; TATA Box Binding Protein-Like Proteins; Telomere; Telomeric Repeat Binding Protein 2; Tumor Cells, Cultured | 2006 |
Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells.
Topics: Anaphase; Angiogenesis Inhibitors; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Oxazoles; Pancreatic Neoplasms; Porphyrins | 2005 |
The telomerase inhibitor telomestatin induces telomere shortening and cell death in Arabidopsis.
Topics: Arabidopsis; Cell Death; Cells, Cultured; Oryza; Oxazoles; RNA, Messenger; Telomerase; Telomere | 2006 |
Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia.
Topics: Acute Disease; Animals; Antineoplastic Agents; GTP-Binding Proteins; Humans; Kinetics; Leukemia; Oxazoles; Telomerase; Transplantation, Heterologous; U937 Cells | 2006 |
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells.
Topics: Cell Line; DNA; G-Quadruplexes; Green Fluorescent Proteins; Humans; Kidney; Nuclear Proteins; Oxazoles; Protein Binding; Recombinant Fusion Proteins; Shelterin Complex; TATA Box Binding Protein-Like Proteins; Telomere; Telomere-Binding Proteins; Telomeric Repeat Binding Protein 2; Transfection | 2006 |
Total synthesis of (R)-telomestatin.
Topics: Molecular Structure; Oxazoles; Streptomyces; Telomerase | 2006 |
Synthesis of the penta-oxazole core of telomestatin in a convergent approach to poly-oxazole macrocycles.
Topics: Macrocyclic Compounds; Oxazoles; Streptomyces | 2006 |
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.
Topics: Base Sequence; Cell Line, Tumor; Chromatin Immunoprecipitation; DNA Damage; DNA Primers; Fluorescent Antibody Technique; Green Fluorescent Proteins; Humans; Oxazoles; Shelterin Complex; Telomere; Telomere-Binding Proteins | 2006 |
Affinity and selectivity of G4 ligands measured by FRET.
Topics: DNA; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; G-Quadruplexes; Humans; Ligands; Nucleic Acid Denaturation; Oxazoles; Polymerase Chain Reaction; Porphyrins; Telomerase; Telomere | 2005 |
Telomerase inhibition combined with other chemotherapeutic reagents to enhance anti-cancer effect.
Topics: Animals; Antineoplastic Agents; Benzamides; Drug Synergism; Humans; Imatinib Mesylate; K562 Cells; Neoplasms; Oxazoles; Piperazines; Pyrimidines; Telomerase | 2007 |
Energetics of the human Tel-22 quadruplex-telomestatin interaction: a molecular dynamics study.
Topics: Computer Simulation; DNA; G-Quadruplexes; Humans; Models, Chemical; Molecular Structure; Oxazoles; Potassium; Telomere | 2008 |
Novel polyoxazole-based cyclopeptides from Streptomyces sp. Total synthesis of the cyclopeptide YM-216391 and synthetic studies towards telomestatin.
Topics: Oxazoles; Peptides, Cyclic; Spectrometry, Mass, Electrospray Ionization | 2008 |
Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences.
Topics: Base Sequence; Cations; DNA; G-Quadruplexes; Humans; Iodine Radioisotopes; Oligodeoxyribonucleotides; Oxazoles; Porphyrins; Potassium; Repetitive Sequences, Nucleic Acid; Sodium; Telomere | 2008 |
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.
Topics: Adenocarcinoma; Blotting, Western; Bone Neoplasms; Colony-Forming Units Assay; Colorectal Neoplasms; DNA Damage; DNA Polymerase iota; DNA Replication; DNA-Directed DNA Polymerase; Flow Cytometry; G-Quadruplexes; Gene Silencing; Genes, myc; HeLa Cells; Histones; Humans; Nucleic Acid Synthesis Inhibitors; Osteosarcoma; Oxazoles; Promoter Regions, Genetic | 2009 |
Studying telomere replication by Q-CO-FISH: the effect of telomestatin, a potent G-quadruplex ligand.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; DNA; DNA Replication; Fibroblasts; In Situ Hybridization, Fluorescence; Metaphase; Mice; Nucleic Acid Hybridization; Oxazoles; Telomerase; Telomere | 2008 |
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells.
Topics: Cell Nucleus; Cell Separation; Cells, Cultured; DNA Topoisomerases, Type I; Flow Cytometry; G-Quadruplexes; Humans; Ligands; Models, Biological; Oligonucleotides; Oxazoles; Protein Binding; Protein Structure, Tertiary; Recombination, Genetic; Telomere | 2009 |
G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer.
Topics: DNA; Fluorescence Resonance Energy Transfer; G-Quadruplexes; Oxazoles; Telomere; Thiazoles | 2009 |
Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development.
Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Fetus; Gene Amplification; Hepatic Stellate Cells; Hepatocytes; Humans; Oxazoles; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Telomerase; Telomere; Transduction, Genetic | 2010 |
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Amino Acid Substitution; Basic-Leucine Zipper Transcription Factors; DNA; DNA Helicases; DNA Repair; Fanconi Anemia Complementation Group Proteins; Humans; In Vitro Techniques; Iron; Mitomycin; Molecular Sequence Data; Mutant Proteins; Mutation, Missense; Oxazoles; Protein Stability; Recombinant Proteins | 2010 |
(S)-stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor.
Topics: Enzyme Inhibitors; G-Quadruplexes; Molecular Structure; Oxazoles; Stereoisomerism; Telomerase | 2011 |
Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes.
Topics: Base Sequence; Biophysical Phenomena; Cations, Monovalent; G-Quadruplexes; Humans; Ligands; Methane; Models, Molecular; Oxazoles; Rhodium | 2011 |
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Topics: Adenosine Triphosphatases; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Exodeoxyribonucleases; HeLa Cells; Histones; Humans; Immunoblotting; Maleimides; Molecular Structure; Oxazoles; Proliferating Cell Nuclear Antigen; RecQ Helicases; S Phase; Stress, Physiological; Time Factors; Topoisomerase I Inhibitors; Topotecan; Werner Syndrome Helicase | 2011 |
Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy.
Topics: G-Quadruplexes; Humans; Microscopy, Atomic Force; Oxazoles; Telomere | 2011 |
An acyclic oligoheteroaryle that discriminates strongly between diverse G-quadruplex topologies.
Topics: DNA; G-Quadruplexes; Molecular Structure; Oxazoles; Structure-Activity Relationship | 2011 |
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.
Topics: Aminoquinolines; DNA; G-Quadruplexes; Humans; Kinetics; Ligands; Oxazoles; Picolinic Acids; Telomerase; Telomere; Thermodynamics | 2011 |
Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; DNA Damage; G-Quadruplexes; Gene Expression; Genes, myb; Glioma; Humans; Mice; Neoplastic Stem Cells; Neural Stem Cells; Oxazoles; Proto-Oncogene Mas; Xenograft Model Antitumor Assays | 2012 |
The polymorphisms of DNA G-quadruplex investigated by docking experiments with telomestatin enantiomers.
Topics: Binding Sites; DNA; G-Quadruplexes; Humans; Models, Molecular; Oxazoles; Stereoisomerism; Telomere | 2012 |
The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Motifs; Animals; Basic-Leucine Zipper Transcription Factors; Catalysis; Cell Line; Cell Survival; Chickens; Chromatography; Dimerization; DNA Repair; Fanconi Anemia Complementation Group Proteins; Glycerol; HeLa Cells; Humans; Hydrolysis; Kinetics; Models, Biological; Models, Genetic; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Oxazoles; Protein Denaturation; Recombinant Proteins; Temperature | 2012 |
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.
Topics: Aging; Animals; Bone and Bones; Brain; Cognition Disorders; DNA Damage; DNA Helicases; Female; Fibroblasts; G-Quadruplexes; Genotype; Heterochromatin; Insulin-Like Growth Factor I; Ligands; Longevity; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Nuclear Proteins; Oxazoles; Phenotype; Stem Cells; Telomere; Thyroxine; X-linked Nuclear Protein | 2013 |
Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand.
Topics: Cell Line, Tumor; DNA; G-Quadruplexes; Humans; Inhibitory Concentration 50; Ligands; Macrocyclic Compounds; Oxazoles; Spectrum Analysis; Telomerase; Telomere | 2013 |
Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative.
Topics: G-Quadruplexes; Humans; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Oxazoles; Solutions; Telomere | 2013 |
G-Quadruplex ligands: Potent inhibitors of telomerase activity and cell proliferation in Plasmodium falciparum.
Topics: Cell Proliferation; Enzyme Activation; Enzyme Inhibitors; G-Quadruplexes; Ligands; Oxazoles; Plasmodium falciparum; Telomerase; Telomere | 2016 |
5' to 3' Unfolding Directionality of DNA Secondary Structures by Replication Protein A: G-QUADRUPLEXES AND DUPLEXES.
Topics: DNA, Single-Stranded; G-Quadruplexes; Humans; Oxazoles; Replication Protein A; Telomere | 2016 |
Binding of Telomestatin to a Telomeric G-Quadruplex DNA Probed by All-Atom Molecular Dynamics Simulations with Explicit Solvent.
Topics: DNA; G-Quadruplexes; Humans; Intercalating Agents; Molecular Docking Simulation; Molecular Dynamics Simulation; Nucleic Acid Conformation; Oxazoles; Streptomyces; Telomere | 2016 |
A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions.
Topics: Binding Sites; Carbocyanines; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; G-Quadruplexes; Humans; Oxazoles; Plasmids; Single Molecule Imaging; Staining and Labeling | 2017 |
Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units.
Topics: Binding Sites; Circular Dichroism; DNA; G-Quadruplexes; Humans; Ligands; Models, Biological; Molecular Structure; Oxazoles; Polymers; Telomere | 2017 |
Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host.
Topics: Enzyme Inhibitors; Multigene Family; Oxazoles; Promoter Regions, Genetic; Streptomyces; Telomerase | 2017 |
Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; G-Quadruplexes; Glioma; Heterografts; Humans; Macrocyclic Compounds; Mice; Neoplasm Transplantation; Neoplastic Stem Cells; Oxazoles; Treatment Outcome; Tumor Cells, Cultured | 2017 |
A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair.
Topics: Adenosine Triphosphatases; Animals; Aphidicolin; Cell Line; Checkpoint Kinase 1; Chickens; Cisplatin; DNA Breaks, Double-Stranded; DNA Helicases; DNA Repair; DNA Replication; DNA, Single-Stranded; Fanconi Anemia; Fanconi Anemia Complementation Group Proteins; G-Quadruplexes; Mutation, Missense; Oxazoles; Rad51 Recombinase; Recombinases; Replication Protein A; RNA Helicases; Stress, Physiological | 2018 |
Binding of a Telomestatin Derivative Changes the Mechanical Anisotropy of a Human Telomeric G-Quadruplex.
Topics: Anisotropy; Biomechanical Phenomena; G-Quadruplexes; Humans; Models, Molecular; Oxazoles | 2019 |
Cooperative Heteroligand Interaction with G-Quadruplexes Shows Evidence of Allosteric Binding.
Topics: Allosteric Site; Aminoquinolines; Binding Sites; G-Quadruplexes; Humans; Ligands; Models, Molecular; Oxazoles; Picolinic Acids; Telomere | 2020 |
Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease.
Topics: G-Quadruplexes; Isomerism; Ligands; Nucleic Acid Conformation; Oxazoles; Single-Strand Specific DNA and RNA Endonucleases; Telomere; Thermodynamics | 2021 |