Page last updated: 2024-08-21

oxazoles and telomestatin

oxazoles has been researched along with telomestatin in 64 studies

Research

Studies (64)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	36 (56.25)	29.6817
2010's	26 (40.63)	24.3611
2020's	2 (3.13)	2.80

Authors

Authors	Studies
Furihata, K; Hayakawa, Y; Matsuo, K; Ohtani, T; Seto, H; Shin-ya, K; Wierzba, K; Yamada, Y	1
Hurley, LH; Kim, MY; Shin-Ya, K; Vankayalapati, H; Wierzba, K	1
Gleason-Guzman, M; Hurley, LH; Izbicka, E; Kim, MY; Nishioka, D	1
Nakajima, A; Ohyashiki, JH; Ohyashiki, K; Sashida, G; Shimamoto, T; Shin-Ya, K; Sumi, M; Tauchi, T	1
De Pauw, E; Gabelica, V; Rosu, F; Shin-ya, K	1
Gomez, D; Lacroix, L; Lemarteleur, T; Mailliet, P; Mergny, JL; Riou, JF	1
Anderson, KC; Hurley, LH; Koley, H; Li, C; Munshi, NC; Shammas, MA; Shmookler Reis, RJ	1
Gotoh, A; Nakajima, A; Ohyashiki, JH; Ohyashiki, K; Sashida, G; Shin-Ya, K; Sumi, M; Tauchi, T	1
Gomez, D; Lemarteleur, T; Mergny, JL; Paterski, R; Riou, JF; Shin-Ya, K	1
Shin-ya, K	2
Bashyam, S; Gokhale, V; Hurley, LH; Seenisamy, J; Shin-Ya, K; Siddiqui-Jain, A; Streiner, N; Sun, D; Vankayalapati, H; White, E; Wilson, WD	1
Bashyam, S; Hurley, LH; Kim, MY; Rezler, EM; Seenisamy, J; White, E; Wilson, WD	1
Atkins, JM; Vedejs, E	1
Guo, K; Hurley, LH; Rusche, JJ; Sun, D	1
Binz, N; Grotzer, MA; Rivera, P; Shalaby, T; Shin-ya, K	1
Ide, T; Seimiya, H; Shin-Ya, K; Tahara, H; Tsuruo, T; Yamada, H	1
Hurley, LH; Liu, W; Sun, D	1
Shin-ya, K; Takahashi, H; Tamura, K; Zhang, L	1
Ohyashiki, JH; Ohyashiki, K; Okabe, S; Sashida, G; Shin-ya, K; Sumi, M; Tauchi, T	1
Douarre, C; Giraud-Panis, MJ; Gomez, D; Kaplan, H; Koebel, P; Kolkes, A; Macadré, J; O'Donohue, MF; Riou, JF; Shin-ya, K; Wenner, T	1
Doi, T; Shin-ya, K; Takahashi, T; Yoshida, M	1
Marson, CM; Saadi, M	1
Brassart, B; Douarre, C; El Khoury, V; Gomez, D; Morjani, H; O'Donohue, MF; Riou, JF; Shin-Ya, K; Trentesaux, C; Wenner, T	1
De Cian, A; Guittat, L; Mergny, JL; Riou, JF; Shin-ya, K	1
Autexier, C; Fakhoury, J; Nimmo, GA	1
Kazuo, SY	1
Ohyashiki, JH; Ohyashiki, K; Tauchi, T	1
Agrawal, S; Maiti, S; Ojha, RP	1
Bertram, A; Deeley, J; Pattenden, G	1
Gaynutdinov, TI; Neumann, RD; Panyutin, IG	1
Huppert, JL	1
Bétous, R; Biard, DS; Cazaux, C; Hoffmann, JS; Pillaire, MJ; Puget, N; Rey, L; Selves, J; Shin-ya, K; Vasquez, KM; Wang, G	1
Arnoult, N; Londoño-Vallejo, JA; Shin-Ya, K	1
Guittat, L; Riou, JF; Shin-ya, K; Sidibe, A; Temime-Smaali, N; Trentesaux, C	1
Iida, K; Nagasawa, K; Shin-Ya, K; Tera, M	1
Anno, K; Chayama, K; Ide, T; Ono, T; Tahara, H; Waki, K	1
Brosh, RM; Deakyne, JS; Kitao, H; Leonard, T; Mazin, AV; Shin-Ya, K; Sommers, JA; Suhasini, AN; Wu, Y	1
Nielsen, MC; Ulven, T	1
Doi, T; Nagasawa, K; Shibata, K; Shin-ya, K; Takagi, M; Takahashi, T; Tera, M; Yoshida, M	1
Garner, TP; Linder, J; Moody, CJ; Searle, MS; Williams, HE	1
Aggarwal, M; Brosh, RM; Shoemaker, RH; Sommers, JA	1
Amemiya, Y; Furunaga, Y; Iida, K; Ikebukuro, K; Nagasawa, K; Nakamura, C; Tera, M	1
Guédin-Beaurepaire, A; Hamon, F; Largy, E; Mergny, JL; Monchaud, D; Nguyen, CH; Riou, JF; Rouchon-Dagois, M; Sidibe, A; Teulade-Fichou, MP	1
Ashbridge, B; Balasubramanian, S; Dhakal, S; Koirala, D; Mao, H; Rodriguez, R; Sannohe, Y; Sugiyama, H	1
Demir, H; Hu, B; Joshi, K; Mazumder, S; Miyazaki, T; Nakano, I; Okabe, S; Pan, Y; Purohit, D; Seimiya, H; Shin-ya, K; Viapiano, M; Yamori, T	1
Chae, J; Han, S; Park, HJ; Vy Thi Le, T	1
Alcaro, S; Artese, A; Costa, G; Distinto, S; Moraca, F; Ortuso, F; Parrotta, L	1
Brosh, RM; Kisker, C; Kitao, H; Kuper, J; Loiland, JA; Sommers, JA; Wu, Y	1
Beier, F; Bérubé, NG; Edwards, M; Jiang, Y; Li, JR; Shin-ya, K; Solomon, LA; Watson, LA	1
Iida, K; Majima, S; Nagasawa, K; Nakamura, T; Seimiya, H	1
Chung, WJ; Heddi, B; Iida, K; Nagasawa, K; Phan, AT; Tera, M	1
Calvo, EP; Wasserman, M	1
Alberti, P; Bourdoncle, A; Delagoutte, E; Gueddouda, NM; Lavrik, O; Mendoza, O; Petruseva, I; Riou, JF; Safa, L; Saintomé, C; Thiébaut, F	1
Mulholland, K; Wu, C	1
Balci, H; Iida, K; Ma, Y; Maleki, P; Nagasawa, K	1
Abraham Punnoose, J; Li, Y; Ma, Y; Mandal, S; Mao, H; Nagasawa, K; Sakuma, M	1
Amagai, K; Eguchi, T; Hashimoto, J; Ikeda, H; Izumikawa, M; Kozone, I; Kudo, F; Nakamura, T; Osada, H; Shin-Ya, K; Takahashi, S	1
Iida, K; Ma, Y; Nagasawa, K; Nakamura, T; Nakano, I; Okabe, S; Sasaki, S; Seimiya, H; Shin-Ya, K; Yamori, T; Yoshida, H	1
Abe, T; Awate, S; Bellani, MA; Bharti, SK; Bradley, L; Branzei, D; Brosh, RM; Khan, I; King, GA; Kitao, H; Kobayashi, K; Neuman, KC; Seol, Y; Shin-Ya, K; Sommers, JA; Vidhyasagar, V; Wold, MS; Wu, Y	1
Cui, Y; Ghimire, C; Iida, K; Jonchhe, S; Mao, H; McCool, M; Nagasawa, K; Park, S; Sasaki, S; Sugiyama, H	1
Ermert, P; Luther, A; Obrecht, D; Zbinden, P	1
Li, Y; Lu, L; Mandal, S; Mao, H; Pandey, S; Shelley, JT; Young, MD	1
Ishikawa, R; Ma, Y; Nagasawa, K; Sasaki, S; Tera, M; Yasuda, M	1

Reviews

8 review(s) available for oxazoles and telomestatin

Article	Year
[Telomerase inhibitor, telomestatin, a specific mechanism to interact with telomere structure]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62, Issue:7 Topics: Oxazoles; Telomerase; Telomere	2004
Novel antitumor and neuroprotective substances discovered by characteristic screenings based on specific molecular targets. Bioscience, biotechnology, and biochemistry, 2005, Volume: 69, Issue:5 Topics: Antineoplastic Agents; Endoplasmic Reticulum Chaperone BiP; Gene Expression; Heat-Shock Proteins; Humans; Macrolides; Molecular Chaperones; Molecular Structure; Neuroprotective Agents; Oligosaccharides; Oxazoles; Pyrroles; Receptors, Glutamate; Telomerase	2005
Harnessing telomerase in cancer therapeutics. Anti-cancer agents in medicinal chemistry, 2007, Volume: 7, Issue:4 Topics: Animals; Antineoplastic Agents; Genetic Therapy; Humans; Immunotherapy; Models, Chemical; Models, Genetic; Neoplasms; Oligonucleotides, Antisense; Oxazoles; Promoter Regions, Genetic; RNA; Telomerase	2007
[Studies on bioactive substances of microbial origin that were screened based on molecular targets]. The Japanese journal of antibiotics, 2007, Volume: 60, Issue:4 Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Macrolides; Molecular Chaperones; Neoplasms; Oligosaccharides; Oxazoles; Telomerase	2007
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes. Chemical Society reviews, 2008, Volume: 37, Issue:7 Topics: Acridines; Base Pairing; Binding Sites; Chemistry, Pharmaceutical; G-Quadruplexes; Gene Targeting; Nucleic Acid Conformation; Nucleic Acids; Oxazoles; Porphyrins; Telomerase; Transcription, Genetic	2008
Macrocyclic G-quadruplex ligands. Current medicinal chemistry, 2010, Volume: 17, Issue:29 Topics: Antineoplastic Agents; G-Quadruplexes; Humans; Ligands; Macrocyclic Compounds; Oxazoles; Porphyrins; Telomere	2010
G-quadruplex binding ligands: from naturally occurring to rationally designed molecules. Current pharmaceutical design, 2012, Volume: 18, Issue:14 Topics: Acridines; Anthraquinones; Berberine; DNA; Drug Design; G-Quadruplexes; Humans; Indole Alkaloids; Ligands; Oxazoles; Porphyrins; Quinolines; RNA	2012
Frontier Between Cyclic Peptides and Macrocycles. Methods in molecular biology (Clifton, N.J.), 2019, Volume: 2001 Topics: Biological Products; Cyclization; Depsipeptides; Humans; Lactones; Macrocyclic Compounds; Oxazoles; Peptide Library; Peptides, Cyclic; Permeability; Protein Conformation; Spiro Compounds; Streptogramins; Thiazoles	2019

Other Studies

56 other study(ies) available for oxazoles and telomestatin

Article	Year
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. Journal of the American Chemical Society, 2001, Feb-14, Volume: 123, Issue:6 Topics: Enzyme Inhibitors; HIV; Humans; Leukemia Virus, Murine; Magnetic Resonance Spectroscopy; Molecular Structure; Oxazoles; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Fast Atom Bombardment; Streptomyces; Telomerase; Tumor Cells, Cultured	2001
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. Journal of the American Chemical Society, 2002, Mar-13, Volume: 124, Issue:10 Topics: DNA; Enzyme Inhibitors; Guanine; Humans; Models, Molecular; Nucleic Acid Conformation; Oxazoles; Repetitive Sequences, Nucleic Acid; Substrate Specificity; Telomerase	2002
The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures. Cancer research, 2003, Jun-15, Volume: 63, Issue:12 Topics: Anaphase; Animals; Cell Line, Transformed; DNA; Enzyme Inhibitors; Humans; Macromolecular Substances; Nucleic Acid Conformation; Oxazoles; Porphyrins; Potassium; Sea Urchins; Single-Strand Specific DNA and RNA Endonucleases; Sodium; Substrate Specificity; Telomerase; Telomere	2003
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene, 2003, Aug-14, Volume: 22, Issue:34 Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Division; DNA Repair; DNA-Binding Proteins; Humans; Leukemia; Oxazoles; Protein Serine-Threonine Kinases; Telomerase; Telomere; Tumor Suppressor Proteins	2003
Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry. Chemical communications (Cambridge, England), 2003, Nov-07, Issue:21 Topics: DNA; G-Quadruplexes; Humans; Kinetics; Models, Molecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligonucleotides; Oxazoles; Spectrometry, Mass, Electrospray Ionization; Telomere; Temperature	2003
Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing. Nucleic acids research, 2004, Volume: 32, Issue:1 Topics: Acridines; Alternative Splicing; Cell Line, Tumor; Down-Regulation; Humans; Introns; Kinetics; Ligands; Oxazoles; Quinolinium Compounds; RNA; Substrate Specificity; Telomerase; Transcription, Genetic; Triazines	2004
Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jan-15, Volume: 10, Issue:2 Topics: Apoptosis; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; DNA Repair; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Multiple Myeloma; Oligonucleotide Array Sequence Analysis; Oxazoles; Recombination, Genetic; Telomerase; Telomere; Time Factors	2004
A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity in acute myeloid leukemia. International journal of oncology, 2004, Volume: 24, Issue:6 Topics: Acute Disease; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Cytarabine; Daunorubicin; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Humans; Leukemia, Myeloid; Male; Middle Aged; Oxazoles; Telomerase; Telomere; U937 Cells	2004
Interaction of telomestatin with the telomeric single-strand overhang. The Journal of biological chemistry, 2004, Oct-01, Volume: 279, Issue:40 Topics: Base Sequence; Binding, Competitive; Cell Line; Cell Survival; DNA; DNA, Single-Stranded; G-Quadruplexes; Humans; Nucleic Acid Conformation; Oxazoles; Sulfuric Acid Esters; Telomere	2004
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure. Journal of the American Chemical Society, 2005, Mar-09, Volume: 127, Issue:9 Topics: Binding, Competitive; DNA; DNA, Single-Stranded; G-Quadruplexes; Genes, myc; Guanine; HeLa Cells; Humans; Models, Molecular; Nucleic Acid Conformation; Oxazoles; Porphyrins; Promoter Regions, Genetic; Selenium Compounds; Substrate Specificity; Surface Plasmon Resonance; Telomere	2005
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure. Journal of the American Chemical Society, 2005, Jul-06, Volume: 127, Issue:26 Topics: Binding Sites; Circular Dichroism; DNA; G-Quadruplexes; Humans; Ligands; Molecular Structure; Oligonucleotides; Oncogene Proteins; Oxazoles; Polymerase Chain Reaction; Porphyrins; Potassium; Selenium Compounds; Sodium; Substrate Specificity; Surface Plasmon Resonance; Telomere	2005
A two-stage iterative process for the synthesis of poly-oxazoles. Organic letters, 2005, Jul-21, Volume: 7, Issue:15 Topics: Combinatorial Chemistry Techniques; Molecular Structure; Oxazoles; Polymers	2005
Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents. Nucleic acids research, 2005, Volume: 33, Issue:18 Topics: Base Sequence; Circular Dichroism; Deoxyribonuclease I; DNA; DNA Footprinting; G-Quadruplexes; Guanine; Humans; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Oxazoles; Polydeoxyribonucleotides; Porphyrins; Potassium Chloride; Promoter Regions, Genetic; Purines; Pyrimidines; Single-Strand Specific DNA and RNA Endonucleases; Vascular Endothelial Growth Factor A	2005
Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells. European journal of cancer (Oxford, England : 1990), 2005, Volume: 41, Issue:18 Topics: Apoptosis; Cell Division; Cell Line, Tumor; Cell Proliferation; Child; Enzyme Inhibitors; Humans; Neuroblastoma; Oxazoles; Proto-Oncogene Mas; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Telomerase; Telomere	2005
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells. Oncogene, 2006, Mar-23, Volume: 25, Issue:13 Topics: Anaphase; Breast Neoplasms; Cell Death; Dose-Response Relationship, Drug; Epithelial Cells; Female; Fibroblasts; HeLa Cells; Humans; Nuclear Proteins; Oxazoles; TATA Box Binding Protein-Like Proteins; Telomere; Telomeric Repeat Binding Protein 2; Tumor Cells, Cultured	2006
Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells. Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:10-12 Topics: Anaphase; Angiogenesis Inhibitors; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Oxazoles; Pancreatic Neoplasms; Porphyrins	2005
The telomerase inhibitor telomestatin induces telomere shortening and cell death in Arabidopsis. Biochimica et biophysica acta, 2006, Volume: 1763, Issue:1 Topics: Arabidopsis; Cell Death; Cells, Cultured; Oryza; Oxazoles; RNA, Messenger; Telomerase; Telomere	2006
Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia. Oncogene, 2006, Sep-21, Volume: 25, Issue:42 Topics: Acute Disease; Animals; Antineoplastic Agents; GTP-Binding Proteins; Humans; Kinetics; Leukemia; Oxazoles; Telomerase; Transplantation, Heterologous; U937 Cells	2006
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer research, 2006, Jul-15, Volume: 66, Issue:14 Topics: Cell Line; DNA; G-Quadruplexes; Green Fluorescent Proteins; Humans; Kidney; Nuclear Proteins; Oxazoles; Protein Binding; Recombinant Fusion Proteins; Shelterin Complex; TATA Box Binding Protein-Like Proteins; Telomere; Telomere-Binding Proteins; Telomeric Repeat Binding Protein 2; Transfection	2006
Total synthesis of (R)-telomestatin. Organic letters, 2006, Aug-31, Volume: 8, Issue:18 Topics: Molecular Structure; Oxazoles; Streptomyces; Telomerase	2006
Synthesis of the penta-oxazole core of telomestatin in a convergent approach to poly-oxazole macrocycles. Organic & biomolecular chemistry, 2006, Nov-07, Volume: 4, Issue:21 Topics: Macrocyclic Compounds; Oxazoles; Streptomyces	2006
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. The Journal of biological chemistry, 2006, Dec-15, Volume: 281, Issue:50 Topics: Base Sequence; Cell Line, Tumor; Chromatin Immunoprecipitation; DNA Damage; DNA Primers; Fluorescent Antibody Technique; Green Fluorescent Proteins; Humans; Oxazoles; Shelterin Complex; Telomere; Telomere-Binding Proteins	2006
Affinity and selectivity of G4 ligands measured by FRET. Nucleic acids symposium series (2004), 2005, Issue:49 Topics: DNA; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; G-Quadruplexes; Humans; Ligands; Nucleic Acid Denaturation; Oxazoles; Polymerase Chain Reaction; Porphyrins; Telomerase; Telomere	2005
Telomerase inhibition combined with other chemotherapeutic reagents to enhance anti-cancer effect. Methods in molecular biology (Clifton, N.J.), 2007, Volume: 405 Topics: Animals; Antineoplastic Agents; Benzamides; Drug Synergism; Humans; Imatinib Mesylate; K562 Cells; Neoplasms; Oxazoles; Piperazines; Pyrimidines; Telomerase	2007
Energetics of the human Tel-22 quadruplex-telomestatin interaction: a molecular dynamics study. The journal of physical chemistry. B, 2008, Jun-05, Volume: 112, Issue:22 Topics: Computer Simulation; DNA; G-Quadruplexes; Humans; Models, Chemical; Molecular Structure; Oxazoles; Potassium; Telomere	2008
Novel polyoxazole-based cyclopeptides from Streptomyces sp. Total synthesis of the cyclopeptide YM-216391 and synthetic studies towards telomestatin. Organic & biomolecular chemistry, 2008, Jun-07, Volume: 6, Issue:11 Topics: Oxazoles; Peptides, Cyclic; Spectrometry, Mass, Electrospray Ionization	2008
Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences. Nucleic acids research, 2008, Volume: 36, Issue:12 Topics: Base Sequence; Cations; DNA; G-Quadruplexes; Humans; Iodine Radioisotopes; Oligodeoxyribonucleotides; Oxazoles; Porphyrins; Potassium; Repetitive Sequences, Nucleic Acid; Sodium; Telomere	2008
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. Molecular carcinogenesis, 2009, Volume: 48, Issue:4 Topics: Adenocarcinoma; Blotting, Western; Bone Neoplasms; Colony-Forming Units Assay; Colorectal Neoplasms; DNA Damage; DNA Polymerase iota; DNA Replication; DNA-Directed DNA Polymerase; Flow Cytometry; G-Quadruplexes; Gene Silencing; Genes, myc; HeLa Cells; Histones; Humans; Nucleic Acid Synthesis Inhibitors; Osteosarcoma; Oxazoles; Promoter Regions, Genetic	2009
Studying telomere replication by Q-CO-FISH: the effect of telomestatin, a potent G-quadruplex ligand. Cytogenetic and genome research, 2008, Volume: 122, Issue:3-4 Topics: Animals; Cell Cycle; Cell Division; Cell Line; DNA; DNA Replication; Fibroblasts; In Situ Hybridization, Fluorescence; Metaphase; Mice; Nucleic Acid Hybridization; Oxazoles; Telomerase; Telomere	2008
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells. PloS one, 2009, Sep-09, Volume: 4, Issue:9 Topics: Cell Nucleus; Cell Separation; Cells, Cultured; DNA Topoisomerases, Type I; Flow Cytometry; G-Quadruplexes; Humans; Ligands; Models, Biological; Oligonucleotides; Oxazoles; Protein Binding; Protein Structure, Tertiary; Recombination, Genetic; Telomere	2009
G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer. Nucleic acids symposium series (2004), 2009, Issue:53 Topics: DNA; Fluorescence Resonance Energy Transfer; G-Quadruplexes; Oxazoles; Telomere; Thiazoles	2009
Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development. Cancer science, 2010, Volume: 101, Issue:7 Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Fetus; Gene Amplification; Hepatic Stellate Cells; Hepatocytes; Humans; Oxazoles; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Telomerase; Telomere; Transduction, Genetic	2010
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood, 2010, Nov-11, Volume: 116, Issue:19 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Amino Acid Substitution; Basic-Leucine Zipper Transcription Factors; DNA; DNA Helicases; DNA Repair; Fanconi Anemia Complementation Group Proteins; Humans; In Vitro Techniques; Iron; Mitomycin; Molecular Sequence Data; Mutant Proteins; Mutation, Missense; Oxazoles; Protein Stability; Recombinant Proteins	2010
(S)-stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor. Organic & biomolecular chemistry, 2011, Jan-21, Volume: 9, Issue:2 Topics: Enzyme Inhibitors; G-Quadruplexes; Molecular Structure; Oxazoles; Stereoisomerism; Telomerase	2011
Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes. Journal of the American Chemical Society, 2011, Feb-02, Volume: 133, Issue:4 Topics: Base Sequence; Biophysical Phenomena; Cations, Monovalent; G-Quadruplexes; Humans; Ligands; Methane; Models, Molecular; Oxazoles; Rhodium	2011
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress. Proceedings of the National Academy of Sciences of the United States of America, 2011, Jan-25, Volume: 108, Issue:4 Topics: Adenosine Triphosphatases; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Exodeoxyribonucleases; HeLa Cells; Histones; Humans; Immunoblotting; Maleimides; Molecular Structure; Oxazoles; Proliferating Cell Nuclear Antigen; RecQ Helicases; S Phase; Stress, Physiological; Time Factors; Topoisomerase I Inhibitors; Topotecan; Werner Syndrome Helicase	2011
Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy. Chemical communications (Cambridge, England), 2011, Jul-14, Volume: 47, Issue:26 Topics: G-Quadruplexes; Humans; Microscopy, Atomic Force; Oxazoles; Telomere	2011
An acyclic oligoheteroaryle that discriminates strongly between diverse G-quadruplex topologies. Angewandte Chemie (International ed. in English), 2011, Sep-05, Volume: 50, Issue:37 Topics: DNA; G-Quadruplexes; Molecular Structure; Oxazoles; Structure-Activity Relationship	2011
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nature chemistry, 2011, Aug-28, Volume: 3, Issue:10 Topics: Aminoquinolines; DNA; G-Quadruplexes; Humans; Kinetics; Ligands; Oxazoles; Picolinic Acids; Telomerase; Telomere; Thermodynamics	2011
Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb. Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Mar-01, Volume: 18, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; DNA Damage; G-Quadruplexes; Gene Expression; Genes, myb; Glioma; Humans; Mice; Neoplastic Stem Cells; Neural Stem Cells; Oxazoles; Proto-Oncogene Mas; Xenograft Model Antitumor Assays	2012
The polymorphisms of DNA G-quadruplex investigated by docking experiments with telomestatin enantiomers. Current pharmaceutical design, 2012, Volume: 18, Issue:14 Topics: Binding Sites; DNA; G-Quadruplexes; Humans; Models, Molecular; Oxazoles; Stereoisomerism; Telomere	2012
The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function. The Journal of biological chemistry, 2012, Jun-22, Volume: 287, Issue:26 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Motifs; Animals; Basic-Leucine Zipper Transcription Factors; Catalysis; Cell Line; Cell Survival; Chickens; Chromatography; Dimerization; DNA Repair; Fanconi Anemia Complementation Group Proteins; Glycerol; HeLa Cells; Humans; Hydrolysis; Kinetics; Models, Biological; Models, Genetic; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Oxazoles; Protein Denaturation; Recombinant Proteins; Temperature	2012
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. The Journal of clinical investigation, 2013, Volume: 123, Issue:5 Topics: Aging; Animals; Bone and Bones; Brain; Cognition Disorders; DNA Damage; DNA Helicases; Female; Fibroblasts; G-Quadruplexes; Genotype; Heterochromatin; Insulin-Like Growth Factor I; Ligands; Longevity; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Nuclear Proteins; Oxazoles; Phenotype; Stem Cells; Telomere; Thyroxine; X-linked Nuclear Protein	2013
Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. Molecules (Basel, Switzerland), 2013, Apr-12, Volume: 18, Issue:4 Topics: Cell Line, Tumor; DNA; G-Quadruplexes; Humans; Inhibitory Concentration 50; Ligands; Macrocyclic Compounds; Oxazoles; Spectrum Analysis; Telomerase; Telomere	2013
Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative. Journal of the American Chemical Society, 2013, Sep-11, Volume: 135, Issue:36 Topics: G-Quadruplexes; Humans; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Oxazoles; Solutions; Telomere	2013
G-Quadruplex ligands: Potent inhibitors of telomerase activity and cell proliferation in Plasmodium falciparum. Molecular and biochemical parasitology, 2016, Volume: 207, Issue:1 Topics: Cell Proliferation; Enzyme Activation; Enzyme Inhibitors; G-Quadruplexes; Ligands; Oxazoles; Plasmodium falciparum; Telomerase; Telomere	2016
5' to 3' Unfolding Directionality of DNA Secondary Structures by Replication Protein A: G-QUADRUPLEXES AND DUPLEXES. The Journal of biological chemistry, 2016, Sep-30, Volume: 291, Issue:40 Topics: DNA, Single-Stranded; G-Quadruplexes; Humans; Oxazoles; Replication Protein A; Telomere	2016
Binding of Telomestatin to a Telomeric G-Quadruplex DNA Probed by All-Atom Molecular Dynamics Simulations with Explicit Solvent. Journal of chemical information and modeling, 2016, 10-24, Volume: 56, Issue:10 Topics: DNA; G-Quadruplexes; Humans; Intercalating Agents; Molecular Docking Simulation; Molecular Dynamics Simulation; Nucleic Acid Conformation; Oxazoles; Streptomyces; Telomere	2016
A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions. Nucleic acids research, 2017, Jan-09, Volume: 45, Issue:1 Topics: Binding Sites; Carbocyanines; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; G-Quadruplexes; Humans; Oxazoles; Plasmids; Single Molecule Imaging; Staining and Labeling	2017
Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units. Journal of the American Chemical Society, 2017, 06-07, Volume: 139, Issue:22 Topics: Binding Sites; Circular Dichroism; DNA; G-Quadruplexes; Humans; Ligands; Models, Biological; Molecular Structure; Oxazoles; Polymers; Telomere	2017
Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host. Scientific reports, 2017, 06-13, Volume: 7, Issue:1 Topics: Enzyme Inhibitors; Multigene Family; Oxazoles; Promoter Regions, Genetic; Streptomyces; Telomerase	2017
Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole. Scientific reports, 2017, 06-15, Volume: 7, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; G-Quadruplexes; Glioma; Heterografts; Humans; Macrocyclic Compounds; Mice; Neoplasm Transplantation; Neoplastic Stem Cells; Oxazoles; Treatment Outcome; Tumor Cells, Cultured	2017
A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair. Nucleic acids research, 2018, 07-06, Volume: 46, Issue:12 Topics: Adenosine Triphosphatases; Animals; Aphidicolin; Cell Line; Checkpoint Kinase 1; Chickens; Cisplatin; DNA Breaks, Double-Stranded; DNA Helicases; DNA Repair; DNA Replication; DNA, Single-Stranded; Fanconi Anemia; Fanconi Anemia Complementation Group Proteins; G-Quadruplexes; Mutation, Missense; Oxazoles; Rad51 Recombinase; Recombinases; Replication Protein A; RNA Helicases; Stress, Physiological	2018
Binding of a Telomestatin Derivative Changes the Mechanical Anisotropy of a Human Telomeric G-Quadruplex. Angewandte Chemie (International ed. in English), 2019, 01-14, Volume: 58, Issue:3 Topics: Anisotropy; Biomechanical Phenomena; G-Quadruplexes; Humans; Models, Molecular; Oxazoles	2019
Cooperative Heteroligand Interaction with G-Quadruplexes Shows Evidence of Allosteric Binding. Biochemistry, 2020, 09-22, Volume: 59, Issue:37 Topics: Allosteric Site; Aminoquinolines; Binding Sites; G-Quadruplexes; Humans; Ligands; Models, Molecular; Oxazoles; Picolinic Acids; Telomere	2020
Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease. Chemical communications (Cambridge, England), 2021, Jul-28, Volume: 57, Issue:59 Topics: G-Quadruplexes; Isomerism; Ligands; Nucleic Acid Conformation; Oxazoles; Single-Strand Specific DNA and RNA Endonucleases; Telomere; Thermodynamics	2021