oxazoles has been researched along with tedizolid phosphate in 106 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (3.77) | 29.6817 |
| 2010's | 95 (89.62) | 24.3611 |
| 2020's | 7 (6.60) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, SH; Gonzalez, E; Molina-Torres, C; Ocampo-Candiani, J; Rendon, A; Velazquez-Moreno, VM; Vera-Cabrera, L; Welsh, O | 1 |
| Bae, SK; Lee, MG; Rhee, JK; Shin, KN; Yang, SH; Yoo, M | 1 |
| Cavazos-Rocha, N; Choi, SH; de Torres, NW; Espinoza-González, NA; Lozano-Garza, G; Ocampo-Candiani, J; Said-Fernandez, S; Vera-Cabrera, L; Welsh, O | 1 |
| Castro-Garza, J; Espinoza-González, NA; Ocampo-Candiani, J; Vera-Cabrera, L; Welsh, O | 1 |
| Brown, SD; Traczewski, MM | 1 |
| Choi, SH; Espinoza-Gonzalez, NA; Lozano-Garza, G; Ocampo-Candiani, J; Said-Fernandez, S; Vera-Cabrera, L; Welsh, O | 1 |
| Bien, P; Bulitta, JB; Corey, GR; DeAnda, C; Mehra, P; Prokocimer, P; Surber, J | 1 |
| Drusano, GL; Kulawy, R; Liu, W; Louie, A | 2 |
| Bartizal, K; Bien, P; Deanda, C; Pillar, CM; Prokocimer, P | 1 |
| Bartizal, K; Choi, S; Im, W | 1 |
| Andes, DR; Craig, WA; Lepak, AJ; Marchillo, K; Pichereau, S | 1 |
| Das, A; De Anda, C; Fang, E; Mehra, P; Prokocimer, P | 1 |
| Boucher, HW; Doron, S | 1 |
| Goering, RV; Thomson, KS | 1 |
| Espona, M; Ferrández, I; Ferrández, O; Grau, S; Salas, E; Urbina, O | 1 |
| Bartizal, K; Fang, E; Flanagan, S; Minassian, SL; Prokocimer, P | 1 |
| Bien, PA; Flanagan, SD; Minassian, SL; Muñoz, KA; Prokocimer, PG | 1 |
| Moellering, RC | 1 |
| Drusano, GL; Lodise, TP | 1 |
| Bartizal, K; Locke, JB; Shaw, KJ; Zurenko, GE | 1 |
| De Anda, C; Fang, E; Green, S; Mehra, P; O'Riordan, W; Prokocimer, P | 1 |
| Das, D; Fang, E; Mehra, P; Prokocimer, P; Tulkens, PM | 1 |
| Bien, P; De Anda, C; Prokocimer, P | 1 |
| Barba-Marines, A; Castro-Garza, J; Cavazos-Rocha, N; Molina-Torres, CA; Ocampo-Candiani, J; Pucci, MJ; Valles-Guerra, O; Vera-Cabrera, L | 1 |
| Bartizal, K; Dreskin, HJ; Fang, E; Flanagan, S; Locke, JB; Ong, V; Prokocimer, P | 1 |
| Corey, GR; Das, AF; De Anda, C; Fang, E; Moran, GJ; Prokocimer, P | 1 |
| Kern, WV; Tacconelli, E | 1 |
| Fang, E; Flanagan, S; Minassian, SL; Muñoz, KA; Prokocimer, PG | 1 |
| Cao, J; Chen, H; He, W; Hu, D; Li, H; Liu, Y; Ma, X; Wang, H; Wang, Q; Wang, X; Wang, Z; Wu, W; Xia, F; Yang, Q; Zhang, F; Zhang, J; Zhang, R; Zhao, C; Zhao, F | 1 |
| Deane, J; Goering, RV; Jenkins, SG; Locke, JB; Sahm, DF; Scharn, CR; Shaw, KJ; Zuill, DE | 1 |
| Alcorn, HW; Fang, E; Flanagan, S; Marbury, TC; Minassian, SL; Morris, D; Ponnuraj, R; Prokocimer, P | 1 |
| Fiedler-Kelly, J; Flanagan, S; Lu, Q; Ludwig, E; Passarell, J; Prokocimer, P | 1 |
| Bensaci, M; Bien, P; Patel, HN; Thorne, G; Zurenko, G | 1 |
| Martin, CA; Marx, K; Rybak, JM | 1 |
| Butt, MT; Draganov, D; Hosako, H; Oleson, F; Radovsky, A; Schlosser, MJ; Vija, J | 1 |
| Bartizal, KF; Bien, PA; Deane, J; Locke, JB; Sahm, DF; Shaw, KJ; Zuill, DE | 1 |
| Gras, J | 1 |
| Strain, J | 1 |
| Adam, H; Gilmour, M; Gin, AS; Golden, A; Gorityala, B; Hoban, DJ; Karlowsky, JA; Lagacé-Wiens, PR; Love, R; Lynch, JP; Rubinstein, E; Schweizer, F; Walkty, A; Zelenitsky, S; Zhanel, GG | 1 |
| Basuino, L; Chambers, HF; Chan, LC; Dip, EC | 1 |
| Hussar, DA | 1 |
| Burdette, SD; Trotman, R | 1 |
| Chahine, EB; Knutsen, SD; Sucher, AJ | 1 |
| Choi, S; Hong, SK; Im, W; Lee, K; Lee, Y; Yong, D | 1 |
| Hui, Y; Xiaoju, L | 1 |
| Chen, KH; Hsueh, PR; Huang, YT; Liao, CH; Sheng, WH | 1 |
| Alsayed, N; Bertolami, S; Flanagan, S; Kennedy, G; Osborn, J | 1 |
| Douros, A; Grabowski, K; Stahlmann, R | 1 |
| Barber, KE; Raut, A; Rybak, MJ; Smith, JR | 1 |
| Betoudji, F; Converse, PJ; Dartois, V; Li, SY; Mdluli, KE; Mendel, CM; Nuermberger, EL; Tasneen, R; Tyagi, S; Williams, K; Yang, T | 1 |
| Bednarek, E; Cielecka-Piontek, J; Gruba, E; Michalska, K | 1 |
| Greenwood Quaintance, KE; Karau, MJ; Patel, R; Schmidt-Malan, SM | 1 |
| Arrieta, AC; Bradley, JS; Capparelli, E; Flanagan, SD; Jacobs, R; Prokocimer, P | 1 |
| Burnham, CA; Crotty, MP; Krekel, T; Ritchie, DJ | 1 |
| Greenwood-Quaintance, KE; Patel, R; Silva-Del Toro, SL | 1 |
| Chellat, MF; Raguž, L; Riedl, R | 1 |
| Baek, JY; Chung, DR; Hsueh, PR; Kang, CI; Kim, SH; Ko, KS; Lee, NY; Peck, KR; So, TM; Song, JH; Thamlikitkul, V | 1 |
| Iqbal, M | 1 |
| Bassetti, M; Concia, E; Cristini, F; De Rosa, FG; Esposito, S; Menichetti, F; Petrosillo, N; Russo, A; Tumbarello, M; Venditti, M; Viale, P; Viscoli, C | 1 |
| Li, R; Nailor, MD | 1 |
| Hasegawa, H; Izumikawa, K; Kaku, N; Kosai, K; Miyazaki, T; Morinaga, Y; Mukae, H; Takeda, K; Uno, N; Yanagihara, K | 1 |
| Abdelhady, W; Bayer, AS; Gonzales, R; Li, L; Xiong, YQ | 1 |
| Bidell, MR; Flanagan, SD; Lodise, TP; Minassian, SL; Prokocimer, P; Zasowski, EJ | 1 |
| Fang, E; Flanagan, S; Litwin, J; Prokocimer, P | 1 |
| Farrell, DJ; Flamm, RK; Jones, RN; Mendes, RE; Pfaller, MA | 1 |
| Chang, X; Chen, R; Hu, P; Li, L; Shen, K; Tanaka, T | 1 |
| Aepfelbacher, M; Belmar Campos, C; Both, A; Büttner, H; Christner, M; Christopeit, M; Klupp, EM; König, C; Rohde, H | 1 |
| Das, AF; De Anda, C; Powers, JH; Prokocimer, P | 1 |
| Dunne, B; Fox, MA; Murphy, CD; Ortin, Y; Palmer-Brown, W; Sandford, G | 1 |
| Greenwood-Quaintance, KE; Mandrekar, J; Park, KH; Patel, R | 1 |
| Cao, B; Chen, H; Chu, Y; Du, Y; Feng, X; Fu, Q; Gui, Q; Guo, Y; Hu, B; Hu, Y; Hu, Z; Ji, P; Jia, W; Jin, Y; Lei, JE; Li, S; Liao, K; Liu, Z; Ni, Y; Wang, H; Wang, Z; Xu, X; Yang, Q; Yu, Y; Zeng, J; Zhang, R; Zhang, Z; Zhao, C; Zhuo, C | 1 |
| Ghazi, I; Hamada, Y; Nicolau, DP | 1 |
| Bensaci, M; Sahm, D | 1 |
| Corey, R; Das, AF; De Anda, C; Nathwani, D; Prokocimer, P; Sandison, T | 1 |
| Arber, M; Barata, T; Eales, J; Fleetwood, K; Glanville, J; Gould, IM; Kauf, TL; McCool, R | 1 |
| Durkin, MJ; Hsueh, K; Krekel, T; McBride, D | 1 |
| Apewokin, SK; Mathur, P; Matin, A; Sharma, S | 1 |
| Bridgeman, MB; Dalal, KS | 1 |
| Das, AF; De Anda, C; Fang, E; Prokocimer, P; Sandison, T | 1 |
| Jin, B; Lei, Y; Li, T; Ma, C; Zhang, T | 1 |
| Rademacher, J; Welte, T | 1 |
| Asai, N; Hagihara, M; Kato, H; Koizumi, Y; Matsuura, K; Mikamo, H; Nishiyama, N; Sakanashi, D; Suematsu, H; Yamagishi, Y | 1 |
| Hasegawa, H; Imamura, Y; Izumikawa, K; Kaku, N; Kosai, K; Miyazaki, T; Morinaga, Y; Mukae, H; Takeda, K; Uno, N; Yanagihara, K | 1 |
| Al-Obeid, S; Dmitrieva, N; Gales, AC; M Blondeau, J; Petukhova, I; Rossi, F; Wilcox, MH | 1 |
| Huang, G; Liu, J; Tian, L; Yang, Z | 1 |
| Auzou, M; Cattoir, V; Compain, F; Michon, J; Piau-Couapel, C; Ract, P | 1 |
| Deshpande, D; Gumbo, T; Lee, PS; Pasipanodya, JG; Srivastava, S | 2 |
| Ruth, MM; van Ingen, J | 1 |
| Flanagan, SD; Minassian, SL; Prokocimer, P | 1 |
| Anuskiewicz, S; De Anda, C; Prokocimer, P; Vazquez, J | 1 |
| Anuskiewicz, S; Bidell, M; De Anda, C; Flanagan, S; Hardalo, C; Lodise, TP; Prokocimer, P | 1 |
| Iwamoto, Y; Kato, M; Kohno, S; Mikamo, H; Takesue, Y; Tanigawa, T; Tanimura, Y | 1 |
| Alvarez, DN; Bayer, AS; Farah, S; Garcia-de-la-Maria, C; Miro, JM; Mishra, NN; Sakoulas, G; Zapata, B | 1 |
| Beringer, PM; D'Argenio, DZ; Fukushima, L; Jayne, J; Park, AYJ; Rao, AP; Wang, J | 1 |
| Feng, HP; Flanagan, S; Flattery, A; Gill, C; Liang, L; Liu, J; Tan, C; Wu, J; Xiao, J | 1 |
| Alder, J; Li, L; Lv, X; O'Riordan, W; Rybak, MJ; Wilcox, MH; Ye, H; Zhang, R; Zhang, Z; Zhu, X | 1 |
| Alós-Almiñana, M; Ezquer-Garin, C; Ferriols-Lisart, R; Martinez-López, LM; Nicolás-Picó, J; Sangrador-Pelluz, C | 1 |
| Mori, M; Takase, A | 1 |
| Atlihan-Gundogdu, E; Demir, ES; Karpuz, M; Senyigit, Z | 1 |
| Ang, JY; Arrieta, AC; Bradley, JS; Chou, MZ; De Anda, CS; Espinosa, C; Fofanov, O; Kim, JY; Li, D; Sabato, P; Sears, PS; Tøndel, C | 1 |
| Broyde, N; Butterton, JR; Croce, M; De Anda, C; Fujimi, S; Kim, JY; Popejoy, MW; Rodriguez Gonzalez, D; Roquilly, A; Wunderink, RG | 1 |
| Abdel-Moety, EM; Fayed, AS; Moaaz, EM; Rezk, MR | 1 |
| Alkholief, M; Alshamsan, A; Alshememry, A; Iqbal, M; Kalam, MA | 1 |
21 review(s) available for oxazoles and tedizolid phosphate
| Article | Year |
|---|---|
Potential role of tedizolid phosphate in the treatment of acute bacterial skin infections.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Biological Availability; Drug Resistance, Bacterial; Gram-Positive Bacteria; Humans; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Soft Tissue Infections; Tissue Distribution | 2013 |
Tedizolid: a novel oxazolidinone for Gram-positive infections.
Topics: Anti-Bacterial Agents; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Organophosphates; Oxazoles; Oxazolidinones | 2014 |
Use of pharmacokinetic/pharmacodynamic systems analyses to inform dose selection of tedizolid phosphate.
Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Disease Models, Animal; Humans; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Pneumonia, Staphylococcal; Staphylococcal Skin Infections; Staphylococcus aureus | 2014 |
Tedizolid for the management of human infections: in vitro characteristics.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gene Transfer, Horizontal; Humans; Linezolid; Organophosphates; Oxazoles; Oxazolidinones; Point Mutation; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus; tRNA Methyltransferases | 2014 |
Tedizolid phosphate for the management of acute bacterial skin and skin structure infections: efficacy summary.
Topics: Anti-Bacterial Agents; Clinical Trials as Topic; Humans; Organophosphates; Oxazoles; Staphylococcal Skin Infections; Treatment Outcome | 2014 |
Tedizolid phosphate for the management of acute bacterial skin and skin structure infections: safety summary.
Topics: Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Humans; Organophosphates; Oxazoles; Staphylococcal Skin Infections | 2014 |
Two new drugs for skin and skin structure infections.
Topics: Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Humans; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Staphylococcal Infections; Teicoplanin | 2014 |
Early experience with tedizolid: clinical efficacy, pharmacodynamics, and resistance.
Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drugs, Investigational; Gram-Positive Bacterial Infections; Humans; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Prodrugs; Staphylococcal Infections; Vancomycin-Resistant Enterococci | 2014 |
Tedizolid phosphate for the treatment of acute bacterial skin and skin structure infections.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Resistance, Bacterial; Humans; Organophosphates; Oxazoles; Skin Diseases, Bacterial | 2014 |
Tedizolid: a novel oxazolidinone with potent activity against multidrug-resistant gram-positive pathogens.
Topics: Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Microbial Sensitivity Tests; Molecular Structure; Organophosphates; Oxazoles; Skin Diseases, Bacterial | 2015 |
Tedizolid: The First Once-Daily Oxazolidinone Class Antibiotic.
Topics: Anti-Bacterial Agents; Clinical Trials, Phase III as Topic; Drug Interactions; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Staphylococcal Skin Infections | 2015 |
Tedizolid: A New Oxazolidinone Antibiotic for Skin and Soft Tissue Infections.
Topics: Adult; Anti-Bacterial Agents; Drug Interactions; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Soft Tissue Infections | 2015 |
Tedizolid for treatment of acute bacterial skin and skin structure infections.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Resistance, Multiple, Bacterial; Humans; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Treatment Outcome | 2015 |
Drug-drug interactions and safety of linezolid, tedizolid, and other oxazolidinones.
Topics: Animals; Anti-Bacterial Agents; Drug Interactions; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Organophosphates; Oxazoles; Oxazolidinones; Structure-Activity Relationship | 2015 |
New Gram-Positive Agents: the Next Generation of Oxazolidinones and Lipoglycopeptides.
Topics: Anti-Infective Agents; Drug Approval; Glycopeptides; Gram-Positive Bacterial Infections; Humans; Lipoglycopeptides; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Teicoplanin; United States; Vancomycin-Resistant Enterococci | 2016 |
Targeting Antibiotic Resistance.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; Drug Design; Drug Resistance, Multiple, Bacterial; Macrolides; Molecular Dynamics Simulation; Organophosphates; Oxazoles; Oxazolidinones; Structure-Activity Relationship | 2016 |
Current and future trends in antibiotic therapy of acute bacterial skin and skin-structure infections.
Topics: Ambulatory Care; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Glycopeptides; Humans; Lipoglycopeptides; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Staphylococcal Skin Infections; Teicoplanin; United States; United States Food and Drug Administration | 2016 |
Systematic review and network meta-analysis of tedizolid for the treatment of acute bacterial skin and skin structure infections caused by MRSA.
Topics: Anti-Bacterial Agents; Bayes Theorem; Ceftaroline; Cephalosporins; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; Staphylococcal Infections; Tetrazoles; Vancomycin | 2017 |
Pharmacokinetic drug evaluation of tedizolid for the treatment of skin infections.
Topics: Animals; Anti-Bacterial Agents; Biological Availability; Drug Interactions; Half-Life; Humans; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Soft Tissue Infections | 2017 |
[New antibiotics - standstill or progress].
Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Infections; Ceftaroline; Ceftazidime; Cephalosporins; Clinical Trials as Topic; Drug Approval; Drug Combinations; Drug Resistance, Multiple, Bacterial; Ephedrine; Humans; Macrolides; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Penicillanic Acid; Phenobarbital; Staphylococcal Infections; Tazobactam; Theophylline; Triazoles | 2017 |
Clinical safety and tolerability of tedizolid phosphate in the treatment of acute bacterial skin and skin structure infections.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Anti-Bacterial Agents; Clinical Trials as Topic; Humans; Linezolid; Organophosphates; Oxazoles; Severity of Illness Index; Skin Diseases, Bacterial | 2018 |
22 trial(s) available for oxazoles and tedizolid phosphate
| Article | Year |
|---|---|
Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; Soft Tissue Infections; Staphylococcal Skin Infections; Staphylococcus aureus; Treatment Outcome; Young Adult | 2011 |
In vitro activity and microbiological efficacy of tedizolid (TR-700) against Gram-positive clinical isolates from a phase 2 study of oral tedizolid phosphate (TR-701) in patients with complicated skin and skin structure infections.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Culture Media; Double-Blind Method; Drug Administration Schedule; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Organophosphates; Oxazoles; Oxazolidinones; Skin; Staphylococcal Skin Infections; Staphylococcus; Tetrazoles | 2012 |
Tedizolid phosphate vs linezolid for treatment of acute bacterial skin and skin structure infections: the ESTABLISH-1 randomized trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Double-Blind Method; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Treatment Outcome; Young Adult | 2013 |
In vitro, in vivo, and clinical studies of tedizolid to assess the potential for peripheral or central monoamine oxidase interactions.
Topics: Acetamides; Adolescent; Adult; Aged; Animals; Anti-Bacterial Agents; Blood Pressure; Female; Humans; Linezolid; Male; Mice; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organophosphates; Oxazoles; Oxazolidinones; Pseudoephedrine; Serotonin; Serotonin Agents; Tetrazoles; Tyramine; Young Adult | 2013 |
Pharmacokinetics of tedizolid following oral administration: single and multiple dose, effect of food, and comparison of two solid forms of the prodrug.
Topics: Administration, Oral; Adolescent; Adult; Chemistry, Pharmaceutical; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Food-Drug Interactions; Humans; Male; Middle Aged; Organophosphates; Oxazoles; Prodrugs; Young Adult | 2014 |
Comparison of digital planimetry and ruler technique to measure ABSSSI lesion sizes in the ESTABLISH-1 study.
Topics: Acetamides; Anti-Bacterial Agents; Erythema; Humans; Image Interpretation, Computer-Assisted; Linezolid; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; United States | 2014 |
Absorption, distribution, metabolism, and excretion of the novel antibacterial prodrug tedizolid phosphate.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Animals; Anti-Bacterial Agents; Dogs; Female; Half-Life; Humans; Kinetics; Male; Microsomes, Liver; Middle Aged; Organophosphates; Oxazoles; Prodrugs; Rats; Rats, Sprague-Dawley; Tissue Distribution; Young Adult | 2014 |
Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial.
Topics: Acetamides; Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Double-Blind Method; Female; Humans; Linezolid; Male; Middle Aged; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; Treatment Outcome; Young Adult | 2014 |
Single- and multiple-dose pharmacokinetics and absolute bioavailability of tedizolid.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Male; Organophosphates; Oxazoles; Pilot Projects; Young Adult | 2014 |
Pharmacokinetics of tedizolid in subjects with renal or hepatic impairment.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Area Under Curve; Bacterial Infections; Cross-Over Studies; Female; Humans; Kidney; Kidney Failure, Chronic; Liver; Liver Diseases; Male; Middle Aged; Organophosphates; Oxazoles; Oxazolidinones; Prodrugs; Renal Dialysis; Tetrazoles; Young Adult | 2014 |
Pharmacokinetics, Safety and Tolerability of Single Oral or Intravenous Administration of 200 mg Tedizolid Phosphate in Adolescents.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Anti-Bacterial Agents; Bacterial Infections; Biological Availability; Blood Chemical Analysis; Child; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Urine | 2016 |
Characterization of the haematological profile of 21 days of tedizolid in healthy subjects.
Topics: Adult; Anti-Bacterial Agents; Blood Cells; Double-Blind Method; Female; Healthy Volunteers; Humans; Linezolid; Male; Middle Aged; Organophosphates; Oxazoles; Placebos; Retrospective Studies; Young Adult | 2016 |
Effects of therapeutic and supratherapeutic doses of oral tedizolid phosphate on cardiac repolarisation in healthy volunteers: a randomised controlled study.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluoroquinolones; Healthy Volunteers; Heart Conduction System; Humans; Male; Middle Aged; Moxifloxacin; Organophosphates; Oxazoles; Placebos; Young Adult | 2016 |
Pharmacokinetics and Safety of Tedizolid after Single and Multiple Intravenous/Oral Sequential Administrations in Healthy Chinese Subjects.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Area Under Curve; Asian People; Biological Availability; China; Cross-Over Studies; Half-Life; Humans; Male; Middle Aged; Organophosphates; Oxazoles; Young Adult | 2016 |
Clinician-reported lesion measurements in skin infection trials: Definitions, reliability, and association with patient-reported pain.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Organophosphates; Oxazoles; Pain; Reproducibility of Results; Research Design; Skin Diseases, Bacterial; Wounds and Injuries; Young Adult | 2016 |
Clinical Response of Tedizolid versus Linezolid in Acute Bacterial Skin and Skin Structure Infections by Severity Measure Using a Pooled Analysis from Two Phase 3 Double-Blind Trials.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Double-Blind Method; Humans; Linezolid; Organophosphates; Oxazoles; Skin; Skin Diseases, Bacterial; Staphylococcal Skin Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes; Young Adult | 2017 |
Pharmacokinetics, Safety, and Tolerability of Tedizolid Phosphate in Elderly Subjects.
Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Area Under Curve; Biological Availability; Drug Administration Schedule; Female; Humans; Male; Organophosphates; Oxazoles | 2018 |
Outpatient treatment of acute bacterial skin and skin structure infections (ABSSSI) with tedizolid phosphate and linezolid in patients in the United States: Subgroup analysis of 2 randomized phase 3 trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Middle Aged; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Treatment Outcome; United States; Young Adult | 2017 |
Efficacy, safety and pharmacokinetics of tedizolid versus linezolid in patients with skin and soft tissue infections in Japan - Results of a randomised, multicentre phase 3 study.
Topics: Aged; Anti-Bacterial Agents; Bacteremia; Female; Humans; Japan; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Prospective Studies; Skin Diseases, Bacterial; Soft Tissue Infections; Treatment Outcome | 2018 |
Efficacy and Safety of Tedizolid Phosphate versus Linezolid in a Randomized Phase 3 Trial in Patients with Acute Bacterial Skin and Skin Structure Infection.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteria; Double-Blind Method; Female; Humans; Male; Middle Aged; Organophosphates; Oxazoles; Skin; Skin Diseases, Bacterial; Young Adult | 2019 |
Pharmacokinetics and Safety of Single-dose Tedizolid Phosphate in Children 2 to <12 Years of Age.
Topics: Administration, Intravenous; Administration, Oral; Anti-Bacterial Agents; Child; Child, Preschool; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Hospitalization; Humans; Male; Organophosphates; Oxazoles | 2021 |
A Phase 3, Randomized, Double-Blind Study Comparing Tedizolid Phosphate and Linezolid for Treatment of Ventilated Gram-Positive Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia.
Topics: Anti-Bacterial Agents; Double-Blind Method; Hospitals; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Pneumonia, Bacterial; Skin Diseases, Bacterial; Ventilators, Mechanical | 2021 |
63 other study(ies) available for oxazoles and tedizolid phosphate
| Article | Year |
|---|---|
In vitro activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis.
Topics: Anti-Bacterial Agents; Humans; Microbial Sensitivity Tests; Mycetoma; Mycobacterium tuberculosis; Nocardia; Organophosphates; Oxazoles; Oxazolidinones; Prodrugs; Tetrazoles | 2006 |
Pharmacokinetics of DA-7218, a new oxazolidinone, and its active metabolite, DA-7157, after intravenous and oral administration of DA-7218 and DA-7157 to rats.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Stability; Injections, Intravenous; Male; Organophosphates; Oxazoles; Oxazolidinones; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley; Tetrazoles | 2007 |
Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by Nocardia brasiliensis.
Topics: Acetamides; Actinomycosis; Animals; Disease Models, Animal; Linezolid; Mice; Mice, Inbred BALB C; Mycetoma; Nocardia; Nocardia Infections; Organophosphates; Oxazoles; Oxazolidinones; Prodrugs; Tetrazoles; Treatment Outcome | 2008 |
Activity of novel oxazolidinones against Nocardia brasiliensis growing within THP-1 macrophages.
Topics: Anti-Bacterial Agents; Cell Line; Colony Count, Microbial; Cytosol; Humans; Macrophages; Microbial Sensitivity Tests; Nocardia; Organophosphates; Oxazoles; Tetrazoles | 2009 |
Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges.
Topics: Disk Diffusion Antimicrobial Tests; Drug Resistance, Bacterial; Enterococcaceae; Gram-Positive Bacteria; History, Medieval; In Vitro Techniques; Indicator Dilution Techniques; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microbiological Techniques; Organophosphates; Oxazoles; Oxazolidinones; Quality Control; Streptococcus; Tetrazoles | 2010 |
Evaluation of the Combined Therapy of DA-7218, a New Oxazolidinone, and Trimethoprim/ Sulfamethoxazole in the Treatment of Experimental Actinomycetoma by Nocardia brasiliensis.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Disease Models, Animal; Drug Therapy, Combination; Female; Mice, Inbred BALB C; Nocardia; Nocardia Infections; Organophosphates; Oxazoles; Trimethoprim, Sulfamethoxazole Drug Combination | 2010 |
In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Female; Humans; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Oxazolidinones; Serum; Staphylococcal Infections; Staphylococcus aureus; Tetrazoles; Thigh | 2011 |
Impact of granulocytes on the antimicrobial effect of tedizolid in a mouse thigh infection model.
Topics: Animals; Anti-Infective Agents; Female; Granulocytes; Mice; Microbial Sensitivity Tests; Models, Theoretical; Organophosphates; Oxazoles; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Tetrazoles; Thigh | 2011 |
Activity of tedizolid phosphate (TR-701) in murine models of infection with penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Culture Media; Drug Administration Schedule; Female; Linezolid; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Microbial Sensitivity Tests; Models, Animal; Organophosphates; Oxazoles; Oxazolidinones; Penicillin Resistance; Penicillins; Pneumonia, Pneumococcal; Streptococcus pneumoniae; Survival Rate | 2012 |
Comparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Area Under Curve; Blood Proteins; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Linezolid; Lung; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Neutropenia; Organophosphates; Oxazoles; Oxazolidinones; Pneumonia, Staphylococcal; Prodrugs; Protein Binding; Staphylococcus aureus | 2012 |
Antibiotics for skin infections: new study design and a step toward shorter course therapy.
Topics: Anti-Infective Agents; Female; Humans; Male; Organophosphates; Oxazoles; Skin Diseases, Bacterial | 2013 |
Activity of tedizolid (TR-700) against well-characterized methicillin-resistant Staphylococcus aureus strains of diverse epidemiological origins.
Topics: Anti-Bacterial Agents; Daptomycin; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minocycline; Organophosphates; Oxazoles; Staphylococcal Infections; Tigecycline | 2013 |
Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages.
Topics: Antitubercular Agents; Bacterial Load; Cell Line; Humans; Macrophages; Mycobacterium tuberculosis; Organophosphates; Oxazoles; Quinolones; Thiazoles | 2014 |
New antibiotics for skin and skin-structure infections.
Topics: Acetamides; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial | 2014 |
In vitro antimicrobial activity of the novel oxazolidinone tedizolid and comparator agents against Staphylococcus aureus and linezolid-resistant Gram-positive pathogens: a multicentre study in China.
Topics: Acetamides; China; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Oxazolidinones; Staphylococcus aureus | 2014 |
Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Clindamycin; Diterpenes; Drug Resistance, Multiple, Bacterial; Gene Transfer Techniques; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Sequence Data; New York; Organophosphates; Oxazoles; Oxazolidinones; Plasmids; Staphylococcal Infections; Thiamphenicol | 2014 |
Tedizolid population pharmacokinetics, exposure response, and target attainment.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Area Under Curve; Biological Availability; Female; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Neutrophils; Organophosphates; Oxazoles; Oxazolidinones; Platelet Count; Prodrugs; Skin Diseases, Bacterial; Staphylococcal Infections; Tetrazoles; Young Adult | 2014 |
Use of linezolid susceptibility test results as a surrogate for the susceptibility of Gram-positive pathogens to tedizolid, a novel oxazolidinone.
Topics: Acetamides; Anti-Bacterial Agents; Biomarkers; Diagnostic Errors; Gram-Positive Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Oxazolidinones | 2014 |
Lack of neuropathological changes in rats administered tedizolid phosphate for nine months.
Topics: Animals; Anti-Bacterial Agents; Female; Linezolid; Male; Neurotoxicity Syndromes; Organophosphates; Oxazoles; Rats; Rats, Inbred LEC | 2015 |
Results of the surveillance of Tedizolid activity and resistance program: in vitro susceptibility of gram-positive pathogens collected in 2011 and 2012 from the United States and Europe.
Topics: Acetamides; Anti-Bacterial Agents; Epidemiological Monitoring; Europe; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Organophosphates; Oxazoles; Oxazolidinones; Ribosomal Proteins; RNA, Ribosomal, 23S; United States | 2015 |
Three new agents added to the arsenal to fight MRSA.
Topics: Anti-Bacterial Agents; Drug Approval; Glycopeptides; Humans; Lipoglycopeptides; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Streptococcal Infections; Teicoplanin; United States; United States Food and Drug Administration | 2014 |
Comparative efficacies of tedizolid phosphate, vancomycin, and daptomycin in a rabbit model of methicillin-resistant Staphylococcus aureus endocarditis.
Topics: Animals; Anti-Bacterial Agents; Daptomycin; Drug Administration Schedule; Endocarditis; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Rabbits; Staphylococcal Infections; Treatment Outcome; Vancomycin | 2015 |
New drugs 2015, part 2.
Topics: Antibodies, Monoclonal, Humanized; Benzhydryl Compounds; Benzofurans; Cyclopropanes; Diphosphates; Drug Approval; Drug Therapy; Glucagon-Like Peptide 1; Glucosides; Glycopeptides; Humans; Lactones; Lipoglycopeptides; Organophosphates; Oxazoles; Pyridines; Sulfates; Teicoplanin; United States; United States Food and Drug Administration | 2015 |
In vitro activity of tedizolid against gram-positive bacteria in patients with skin and skin structure infections and hospital-acquired pneumonia: a Korean multicenter study.
Topics: Anti-Bacterial Agents; Asian People; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Hospitals; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Pneumonia; Republic of Korea; Skin; Skin Diseases | 2015 |
In Vitro Activities of Tedizolid and Linezolid against Gram-Positive Cocci Associated with Acute Bacterial Skin and Skin Structure Infections and Pneumonia.
Topics: Acute Disease; Anti-Bacterial Agents; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Pneumonia, Bacterial; Staphylococcal Skin Infections; Streptococcal Infections; Streptococcus agalactiae; Streptococcus anginosus; Streptococcus pyogenes; Taiwan; Vancomycin-Resistant Enterococci | 2015 |
Stability of Crushed Tedizolid Phosphate Tablets for Nasogastric Tube Administration.
Topics: Anti-Bacterial Agents; Drug Stability; In Vitro Techniques; Intubation, Gastrointestinal; Organophosphates; Oxazoles; Powders; Tablets; Water | 2015 |
Evaluation of tedizolid against Staphylococcus aureus and enterococci with reduced susceptibility to vancomycin, daptomycin or linezolid.
Topics: Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Enterococcus; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Staphylococcus aureus; Vancomycin | 2016 |
Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis.
Topics: Animals; Antitubercular Agents; Bacterial Load; Diarylquinolines; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Synergism; Female; Linezolid; Lung; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Nitroimidazoles; Organophosphates; Oxazoles; Oxazolidinones; Pyrazinamide; Time Factors; Treatment Outcome; Tuberculosis, Pulmonary | 2016 |
Chiral separation of tedizolid using charge single isomer derivatives of cyclodextrins by capillary electrokinetic chromatography.
Topics: Cyclodextrins; Electrophoresis, Capillary; Linezolid; Organophosphates; Oxazoles; Stereoisomerism | 2016 |
In vitro activity of tedizolid against staphylococci isolated from prosthetic joint infections.
Topics: Anti-Bacterial Agents; Arthritis, Infectious; Humans; Inhibitory Concentration 50; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus | 2016 |
In vitro activity of tedizolid against linezolid-resistant staphylococci and enterococci.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Organophosphates; Oxazoles; RNA, Ribosomal, 23S; Staphylococcus | 2016 |
In vitro activity of Tedizolid phosphate against multidrug-resistant Streptococcus pneumoniae isolates from Asian countries.
Topics: Anti-Bacterial Agents; Asia; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Pneumonia, Pneumococcal; Streptococcal Infections; Streptococcus pneumoniae | 2016 |
A highly sensitive and efficient UPLC-MS/MS assay for rapid analysis of tedizolid (a novel oxazolidinone antibiotic) in plasma sample.
Topics: Animals; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Female; Limit of Detection; Liquid-Liquid Extraction; Organophosphates; Oxazoles; Oxazolidinones; Rats, Wistar; Tandem Mass Spectrometry | 2016 |
New Gram Positive Agents to Treat Acute Bacterial Skin and Skin Structure Infections.
Topics: Anti-Bacterial Agents; Clinical Trials, Phase III as Topic; Costs and Cost Analysis; Glycopeptides; Humans; Lipoglycopeptides; Organophosphates; Oxazoles; Practice Guidelines as Topic; Skin Diseases, Bacterial; Teicoplanin; Treatment Outcome | 2016 |
Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Cytokines; Disease Models, Animal; Immunologic Factors; Lung; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Organophosphates; Oxazoles; Plasma; Pneumonia, Staphylococcal; Survival Analysis; Treatment Outcome | 2016 |
Comparative Efficacies of Tedizolid Phosphate, Linezolid, and Vancomycin in a Murine Model of Subcutaneous Catheter-Related Biofilm Infection Due to Methicillin-Susceptible and -Resistant Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Catheter-Related Infections; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Mice; Organophosphates; Oxazoles; Staphylococcus aureus; Vancomycin | 2016 |
Activities of Tedizolid and Linezolid Determined by the Reference Broth Microdilution Method against 3,032 Gram-Positive Bacterial Isolates Collected in Asia-Pacific, Eastern Europe, and Latin American Countries in 2014.
Topics: Anti-Bacterial Agents; Asia; Enterococcus faecalis; Europe, Eastern; Gram-Positive Bacterial Infections; Humans; Latin America; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Staphylococcus aureus; Streptococcus agalactiae; Streptococcus pyogenes | 2016 |
Tedizolid susceptibility in linezolid- and vancomycin-resistant Enterococcus faecium isolates.
Topics: Anti-Bacterial Agents; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Organophosphates; Oxazoles; RNA, Ribosomal, 23S; Vancomycin-Resistant Enterococci | 2016 |
Biotransformation of fluorophenyl pyridine carboxylic acids by the model fungus Cunninghamella elegans.
Topics: Biotransformation; Carboxylic Acids; Chromatography, High Pressure Liquid; Cunninghamella; Gas Chromatography-Mass Spectrometry; Lactones; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Organophosphates; Oxazoles; Pyridines | 2017 |
Activity of Tedizolid in Methicillin-Resistant Staphylococcus aureus Experimental Foreign Body-Associated Osteomyelitis.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Bone Wires; Disease Models, Animal; Drug Combinations; Drug Resistance, Bacterial; Foreign Bodies; Injections, Intraperitoneal; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Organophosphates; Osteomyelitis; Oxazoles; Rats; Rats, Wistar; Rifampin; Staphylococcal Infections; Tibia; Vancomycin | 2016 |
In vitro activities of tedizolid compared with other antibiotics against Gram-positive pathogens associated with hospital-acquired pneumonia, skin and soft tissue infection and bloodstream infection collected from 26 hospitals in China.
Topics: Anti-Bacterial Agents; China; Cross Infection; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Hospitals; Humans; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Pneumonia, Bacterial; Sepsis; Skin Diseases, Bacterial; Soft Tissue Infections | 2016 |
Physical compatibility of tedizolid phosphate with selected i.v. drugs during simulated Y-site administration.
Topics: Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Drug Incompatibility; Infusions, Intravenous; Organophosphates; Oxazoles; Pharmaceutical Solutions | 2016 |
Surveillance of tedizolid activity and resistance: In vitro susceptibility of Gram-positive pathogens collected over 5 years from the United States and Europe.
Topics: Anti-Bacterial Agents; Epidemiological Monitoring; Europe; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Microbial Sensitivity Tests; Organophosphates; Oxazoles; United States | 2017 |
Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials.
Topics: Anti-Bacterial Agents; Clinical Trials, Phase III as Topic; Humans; Linezolid; Models, Statistical; Organophosphates; Oxazoles; Randomized Controlled Trials as Topic; Retrospective Studies; Sensitivity and Specificity; Skin Diseases, Bacterial; Time Factors; Treatment Outcome | 2017 |
Myelosuppression-sparing treatment of central nervous system nocardiosis in a multiple myeloma patient utilizing a tedizolid-based regimen: a case report.
Topics: Aged; Anti-Bacterial Agents; Antineoplastic Agents; Brain; Central Nervous System Infections; Debridement; Female; Florida; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Multiple Myeloma; Nocardia; Nocardia Infections; Organophosphates; Oxazoles; Treatment Outcome | 2017 |
Antibiotics.
Topics: Acute Disease; Anti-Bacterial Agents; Glycopeptides; Humans; Lipoglycopeptides; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Teicoplanin | 2017 |
Identification of forced degradation products of tedizolid phosphate by liquid chromatography/electrospray ionization tandem mass spectrometry.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Hydrolysis; Organophosphates; Oxazoles; Oxidation-Reduction; Rats; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2017 |
Efficacy of tedizolid against methicillin-resistant Staphylococcus aureus and Peptostreptococcus anaerobius in thigh mixed-infection mouse model.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Female; Gram-Positive Bacterial Infections; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Peptostreptococcus; Staphylococcal Infections; Thigh | 2017 |
Tedizolid inhibits MUC5AC production induced by methicillin-resistant Staphylococcus aureus in human airway epithelial cells.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Culture Media, Conditioned; Epithelial Cells; Gene Expression; Humans; MAP Kinase Signaling System; Methicillin-Resistant Staphylococcus aureus; Mice; Mitogen-Activated Protein Kinases; Mucin 5AC; NF-kappa B; Organophosphates; Oxazoles; Phosphorylation; Respiratory Mucosa | 2017 |
Susceptibility testing and reporting of new antibiotics with a focus on tedizolid: an international working group report.
Topics: Americas; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Europe; Humans; International Cooperation; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Saudi Arabia | 2017 |
Construction and evaluation in vitro and in vivo of tedizolid phosphate loaded cationic liposomes.
Topics: Animals; Cations; Drug Carriers; Liposomes; Mice; Nanoparticles; Organophosphates; Oxazoles; Particle Size; Tissue Distribution | 2018 |
In vitro activity of tedizolid and comparator agents against Gram-positive pathogens responsible for bone and joint infections.
Topics: Anti-Bacterial Agents; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Joint Diseases; Microbial Sensitivity Tests; Organophosphates; Osteomyelitis; Oxazoles | 2017 |
Tedizolid is highly bactericidal in the treatment of pulmonary Mycobacterium avium complex disease.
Topics: Anti-Bacterial Agents; Area Under Curve; Humans; Lung Diseases; Macrophages; Microbial Sensitivity Tests; Models, Biological; Monte Carlo Method; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Organophosphates; Oxazoles; THP-1 Cells | 2017 |
A novel ceftazidime/avibactam, rifabutin, tedizolid and moxifloxacin (CARTM) regimen for pulmonary Mycobacterium avium disease.
Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Ceftazidime; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Fluoroquinolones; Humans; Lung Diseases; Macrophages; Microbial Sensitivity Tests; Models, Biological; Moxifloxacin; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Organophosphates; Oxazoles; Rifabutin; THP-1 Cells | 2017 |
New insights in the treatment of nontuberculous mycobacterial pulmonary disease.
Topics: Anti-Bacterial Agents; Clofazimine; Humans; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Organophosphates; Oxazoles; Pneumonia; Treatment Outcome | 2017 |
Prevention of High-Level Daptomycin-Resistance Emergence In Vitro in Streptococcus mitis-oralis by Using Combination Antimicrobial Strategies.
Topics: Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Daptomycin; Drug Combinations; Drug Resistance, Bacterial; Gentamicins; Humans; Imipenem; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Rifampin; Streptococcus mitis; Streptococcus oralis; Trimethoprim, Sulfamethoxazole Drug Combination | 2018 |
Pharmacokinetics of Tedizolid in Plasma and Sputum of Adults with Cystic Fibrosis.
Topics: Administration, Intravenous; Administration, Oral; Adult; Anti-Bacterial Agents; Biological Availability; Cross-Over Studies; Cystic Fibrosis; Female; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Plasma; Prospective Studies; Sputum | 2018 |
Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Neutropenia; Organophosphates; Oxazoles; Staphylococcal Skin Infections | 2019 |
Stability of tedizolid phosphate-sodium rifampicin and tedizolid phosphate-meropenem admixtures in intravenous infusion bags stored at different temperatures.
Topics: Anti-Bacterial Agents; Chromatography, Liquid; Drug Stability; Drug Storage; Freezing; Infusions, Intravenous; Meropenem; Organophosphates; Oxazoles; Polypropylenes; Refrigeration; Rifampin; Sodium Chloride; Temperature; Time Factors | 2020 |
[Pharmacological action and clinical effect of tedizolid phosphate (SIVEXTRO
Topics: Anti-Bacterial Agents; Humans; Japan; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Oxazolidinones; Staphylococcus aureus; Tablets | 2020 |
Radiolabeled Tedizolid Phosphate Liposomes for Topical Application: Design, Characterization, and Evaluation of Cellular Binding Capacity.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Drug Compounding; Drug Delivery Systems; Drug Liberation; Humans; Liposomes; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Technetium | 2021 |
Stability-Indicating Determination of Tedizolid Phosphate in the Presence of its Active Form and Possible Degradants.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hydrolysis; Organophosphates; Oxazoles; Reproducibility of Results | 2022 |
Development and Evaluation of Chitosan Nanoparticles for Ocular Delivery of Tedizolid Phosphate.
Topics: Animals; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Nanoparticles; Organophosphates; Oxazoles; Particle Size; Rabbits; Renal Dialysis | 2022 |